M Durner, M A Keddache, L Tomasini, S Shinnar, S R Resor, J Cohen, C Harden, S L Moshe, D Rosenbaum, H Kang, K Ballaban-Gil, S Hertz, D R Labar, D Luciano, S Wallace, D Yohai, I Klotz, E Dicker, D A Greenberg
Idiopathic generalized epilepsy (IGE) is a common, complex disease with an almost exclusively genetic etiology but with variable phenotypes. Clinically, IGE can be divided into different syndromes. Varying lines of evidence point to the involvement of several interacting genes in the etiology of IGE. We performed a genome scan in 91 families ascertained through a proband with adolescent-onset IGE. The IGEs included juvenile myoclonic epilepsy (JME), juvenile absence epilepsy (JAE), and epilepsy with generalized tonic clonic seizures (EGTCS)...
March 2001: Annals of Neurology