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https://www.readbyqxmd.com/read/27851727/high-resolution-crystal-structure-of-the-human-cb1-cannabinoid-receptor
#1
Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang, Daniel M Rosenbaum
The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG), as well as the widely consumed plant (phyto)cannabinoid Δ(9)-tetrahydrocannabinol (THC)(1). The cannabinoid receptors have been the targets of intensive drug discovery efforts owing to the therapeutic potential of modulators for controlling pain(2), epilepsy(3), obesity(4), and other maladies. Although much progress has recently been made in understanding the biophysical properties of GPCRs, investigations of the molecular mechanisms of the cannabinoids and their receptors have lacked high-resolution structural data...
November 16, 2016: Nature
https://www.readbyqxmd.com/read/27188686/cerebral-palsy
#2
H Kerr Graham, Peter Rosenbaum, Nigel Paneth, Bernard Dan, Jean-Pierre Lin, Diane L Damiano, Jules G Becher, Deborah Gaebler-Spira, Allan Colver, Dinah S Reddihough, Kylie E Crompton, Richard L Lieber
Cerebral palsy is the most common cause of childhood-onset, lifelong physical disability in most countries, affecting about 1 in 500 neonates with an estimated prevalence of 17 million people worldwide. Cerebral palsy is not a disease entity in the traditional sense but a clinical description of children who share features of a non-progressive brain injury or lesion acquired during the antenatal, perinatal or early postnatal period. The clinical manifestations of cerebral palsy vary greatly in the type of movement disorder, the degree of functional ability and limitation and the affected parts of the body...
2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/26469801/quality-of-life-in-children-with-epilepsy-how-does-it-compare-with-the-quality-of-life-in-typical-children-and-children-with-cerebral-palsy
#3
COMPARATIVE STUDY
Meron Mezgebe, Gileh-Gol Akhtar-Danesh, David L Streiner, Nora Fayed, Peter L Rosenbaum, Gabriel M Ronen
Our objective was to compare the quality of life (QoL) of children with epilepsy to that of typical children and children with cerebral palsy (CP). We measured self- and proxy-reported QoL of children with epilepsy and contrasted that with data for typical children (European KIDSCREEN project) and children with CP (SPARCLE study). Children ages 8-12 years with epilepsy were recruited from six Canadian sites. Same-aged children with CP and children in the general population aged 8-11 years came from several European countries...
November 2015: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26039224/national-trends-and-in-hospital-complication-rates-in-more-than-1600-hemispherectomies-from-1988-to-2010-a-nationwide-inpatient-sample-study
#4
Sumeet Vadera, Sandra D Griffith, Benjamin P Rosenbaum, Andreea Seicean, Varun R Kshettry, Michael L Kelly, Robert J Weil, William Bingaman, Lara Jehi
BACKGROUND: Anatomic and functional hemispherectomies are relatively infrequent and technically challenging. The literature is limited by small samples and single institution data. OBJECTIVE: We used the Nationwide Inpatient Sample (NIS) database to report on a large population of hemispherectomy patients and their in-hospital complication rates over a 23-year period. METHODS: Between 1988 and 2010, we identified 304 pediatric hospitalizations in the NIS database where hemispherectomy was performed...
August 2015: Neurosurgery
https://www.readbyqxmd.com/read/25841031/children-s-perspective-of-quality-of-life-in-epilepsy
#5
Nora Fayed, Aileen M Davis, David L Streiner, Peter L Rosenbaum, Charles E Cunningham, Lucyna M Lach, Michael H Boyle, Gabriel M Ronen
OBJECTIVE: To study child mental health, parental support, and social support of children with epilepsy as these relate to quality of life (QOL) using child self-report, seizure-related variables, and estimated verbal intelligence based on receptive vocabulary. METHODS: A cross-sectional structural equation model of baseline data from the QUALITÉ cohort study, which includes 6 Canadian child epilepsy ambulatory programs. A sample of 3,481 children were screened for the following eligibility: 8 to 14 years of age, with active or medication-managed epilepsy...
May 5, 2015: Neurology
https://www.readbyqxmd.com/read/24370172/outcomes-trajectories-in-children-with-epilepsy-hypotheses-and-methodology-of-a-canadian-longitudinal-observational-study
#6
Gabriel M Ronen, David L Streiner, Michael H Boyle, Charles E Cunningham, Lucyna Lach, Leonard H Verhey, Nora Fayed, Karen Chen, Peter L Rosenbaum, Mary Connolly, Luis E Bello-Espinosa, Mubeen F Rafay, Juan Pablo Appendino, Michael Shevell, Lionel Carmant
BACKGROUND: The impact of childhood epilepsy can only be appreciated by understanding that epilepsy comprises a set of complex neurobehavioral conditions with significant social consequences, and not simply disorders of recurrent seizures. Our objective is to describe the hypotheses and methodology behind a large prospective longitudinal study that is based on a conceptual framework for understanding health outcomes. The study will quantify the specific influences--direct, mediating or moderating--that various epilepsy, comorbid, child, and family variables exert on health over the early life course...
January 2014: Pediatric Neurology
https://www.readbyqxmd.com/read/23220463/age-related-variables-in-childhood-epilepsy-how-do-they-relate-to-each-other-and-to-quality-of-life
#7
Lindsay Manor, David L Streiner, Winnie K L Yam, Peter L Rosenbaum, Leonard H Verhey, Lucyna Lach, Gabriel M Ronen
How do age of onset and duration of epilepsy correlate with each other and with patient-reported outcomes? To address this question, we explored whether age of onset, duration, and proportion of life with epilepsy are either similar or relatively independent variables that can be used as markers on how children experience the complexity of epilepsy and adjustment. Three hundred ninety-one Canadian and 266 Hong Kong youth with epilepsy completed the childhood epilepsy-specific quality of life (QOL) measure (CHEQOL-25)...
January 2013: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/22496530/%C3%AE-adrenergic-modulation-of-spontaneous-spatiotemporal-activity-patterns-and-synchrony-in-hyperexcitable-hippocampal-circuits
#8
Anupam Hazra, Robert Rosenbaum, Bernhard Bodmann, Siyuan Cao, Krešimir Josić, Jokūbas Žiburkus
A description of healthy and pathological brain dynamics requires an understanding of spatiotemporal patterns of neural activity and characteristics of its propagation between interconnected circuits. However, the structure and modulation of the neural activation maps underlying these patterns and their propagation remain elusive. We investigated effects of β-adrenergic receptor (β-AR) stimulation on the spatiotemporal characteristics of emergent activity in rat hippocampal circuits. Synchronized epileptiform-like activity, such as interictal bursts (IBs) and ictal-like events (ILEs), were evoked by 4-aminopyridine (4-AP), and their dynamics were studied using a combination of electrophysiology and fast voltage-sensitive dye imaging...
July 2012: Journal of Neurophysiology
https://www.readbyqxmd.com/read/21777477/exercise-augmentation-compared-to-usual-care-for-post-traumatic-stress-disorder-a-randomised-controlled-trial-the-reap-study-randomised-exercise-augmentation-for-ptsd
#9
RANDOMIZED CONTROLLED TRIAL
Simon Rosenbaum, Dang Nguyen, Tom Lenehan, Anne Tiedemann, Hidde P van der Ploeg, Catherine Sherrington
BACKGROUND: The physical wellbeing of people with mental health conditions can often be overlooked in order to treat the primary mental health condition as a priority. Exercise however, can potentially improve both the primary psychiatric condition as well as physical measures that indicate risk of other conditions such as diabetes mellitus and cardiovascular disease. Evidence supports the role of exercise as an important component of treatment for depression and anxiety, yet no randomised controlled trials (RCT's) have been conducted to evaluate the use of exercise in the treatment of people with post traumatic stress disorder (PTSD)...
2011: BMC Psychiatry
https://www.readbyqxmd.com/read/21401584/outcomes-in-pediatric-neurology-a-review-of-conceptual-issues-and-recommendationsthe-2010-ronnie-mac-keith-lecture
#10
REVIEW
Gabriel M Ronen, Nora Fayed, Peter L Rosenbaum
This paper discusses how to evaluate whether, and in what ways, treatments affect the lives of children with neurological conditions and their families. We argue that professionals should incorporate perspectives from patients and families to help them make decisions about what 'outcomes' are important, and we discuss how those outcomes might be assessed. A case vignette illustrates the differences and complementarity between the perspectives of clinicians and those of children and their parents. We recommend methods for expanding the range of relevant health outcomes in child neurology to include those that reflect the ways patients and families view their conditions and our interventions...
April 2011: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/21328046/-transient-splenial-lesion-in-influenza-a-h1n1-2009-infection
#11
K Linden, O Moser, A Simon, A-M Eis-Hübinger, G Fleischhack, M Born, H Tschampa, T Rosenbaum, B Köster, M Lentze
Severe neurologic complications have been rarely reported during novel pandemic influenza A(H1N1) virus infections. We describe the case of an 10-year-old boy with new onset seizures and proven influenza A(H1N1) 2009 infection showing a reversible hyperintense lesion in the splenium of the corpus callosum on T2-weighted and FLAIR magnetic resonance images without contrast enhancement. Transient splenial lesions have been described in the context of virus encephalopathy and do not require specific treatment.
March 2011: Der Radiologe
https://www.readbyqxmd.com/read/20478747/disease-characteristics-and-psychosocial-factors-explaining-the-expression-of-quality-of-life-in-childhood-epilepsy
#12
Gabriel M Ronen, David L Streiner, Leonard H Verhey, Lucyna Lach, Michael H Boyle, Charles E Cunningham, Peter L Rosenbaum
OBJECTIVES: To explore, identify and understand the contribution that biomedical and psychosocial factors make to the assessment of health-related quality of life (HRQL) of children and youth with epilepsy using the CHEQOL-25. METHODS: We identified and measured variables that may influence HRQL; grouped the variables into four conceptual categories; and used simple and hierarchical linear regressions to model CHEQOL-25 as a function of these variable groupings...
May 2010: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/19627340/quality-of-life-instruments-for-children-and-adolescents-with-neurodisabilities-how-to-choose-the-appropriate-instrument
#13
REVIEW
Elizabeth Waters, Elise Davis, Gabriel M Ronen, Peter Rosenbaum, Michael Livingston, Saroj Saigal
AIM: There are many misconceptions about what constitutes 'quality of life' (QoL). It is often difficult for researchers and clinicians to determine which instruments will be most appropriate to their purpose. The aim of the current paper is to describe QoL instruments for children and adolescents with neurodisabilities against criteria that we think are important when choosing or developing a QoL instrument. METHOD: QoL instruments for children and adolescents with neurodisabilities were reviewed and described based on their purpose, conceptual focus, origin of domains and items, opportunity for self report, clarity (lack of ambiguity), potential threat to self-esteem, cognitive or emotional burden, number of items and time to complete, and psychometric properties...
August 2009: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/19126437/quality-of-life-in-childhood-epilepsy-what-is-the-level-of-agreement-between-youth-and-their-parents
#14
L H Verhey, D M Kulik, G M Ronen, P Rosenbaum, L Lach, D L Streiner
Children and parents evaluate the child's quality of life (QOL) from their own perspectives; therefore, responses may differ, especially in abstract domains. We examined differences between self- and proxy-reported QOL of children with epilepsy. Children with active epilepsy (N=375) and their parents (N=378) separately completed the CHEQOL-25, a condition-specific QOL measure. The intraclass correlation coefficient was used to determine interrater agreement. Concordance on the Total CHEQOL-25 was 0.45 (P<0...
February 2009: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/18158271/health-related-quality-of-life-of-children-with-epilepsy-in-hong-kong-how-does-it-compare-with-that-of-youth-with-epilepsy-in-canada
#15
COMPARATIVE STUDY
Winnie K L Yam, Gabriel M Ronen, Sharon W W Cherk, Peter Rosenbaum, K Y Chan, David L Streiner, Sally W W Cheng, C W Fung, Jackson C S Ho, Karen L Kwong, Louis C K Ma, David K H Ma, K W Tsui, Virginia Wong, Theresa Y L Wong
OBJECTIVE: The primary aim of our study was to compare the health-related quality of life (HRQL) of children with epilepsy in Hong Kong with that of children with epilepsy in Canada, and to explore possible factors affecting these findings. A second interest was to determine agreement between proxy reports and self-ratings among children with epilepsy in Hong Kong, compare these with findings in Canada, and identify factors that influence the concordance. METHODS: Child self-report and parent-proxy questionnaires on an epilepsy-specific HRQL measure, appropriately translated and validated in Chinese, were administered to 266 Hong Kong children and their parents...
April 2008: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/16972164/health-related-quality-of-life-in-youth-with-epilepsy-theoretical-model-for-clinicians-and-researchers-part-i-the-role-of-epilepsy-and-co-morbidity
#16
REVIEW
Lucyna M Lach, Gabriel M Ronen, Peter L Rosenbaum, Charles Cunningham, Michael H Boyle, Shauna Bowman, David L Streiner
Children and adolescents with epilepsy are at increased risk for poor health-related quality of life (HRQL) even in the absence of active seizures. Clinicians who aim to achieve optimal seizure control also need to focus on improving HRQL. This can only be accomplished by recognizing how different features of the epilepsy itself, co-morbid conditions, as well as psychosocial factors can all make a difference to HRQL. These psychosocial factors include child, family and community/society variables that play a role in the well-being of these children...
September 2006: Quality of Life Research
https://www.readbyqxmd.com/read/15230715/fanconi-syndrome-caused-by-antiepileptic-therapy-with-valproic-acid
#17
Martin Knorr, Jörg Schaper, Malte Harjes, Ertan Mayatepek, Thorsten Rosenbaum
PURPOSE: Valproic acid (VPA) is commonly used as an antiepileptic drug (AED). Regular screening for renal side effects is uncommon. Fanconi syndrome, a generalized dysfunction of renal proximal tubular cells, occurs with some inborn errors of metabolism. In addition, it can be acquired by exposure to several toxic substances. We report a case of Fanconi syndrome after long-term therapy with VPA. METHODS: An 8-year-old severely disabled and developmentally retarded boy with epilepsy was treated with VPA over a period of 7 years...
July 2004: Epilepsia
https://www.readbyqxmd.com/read/14854290/life-situations-emotions-and-idiopathic-epilepsy
#18
J HIGGINS, H LEDERER, M ROSENBAUM
No abstract text is available yet for this article.
December 1949: Research Publications—Association for Research in Nervous and Mental Disease
https://www.readbyqxmd.com/read/14498989/health-related-quality-of-life-in-childhood-epilepsy-moving-beyond-seizure-control-with-minimal-adverse-effects
#19
REVIEW
Gabriel M Ronen, David L Streiner, Peter Rosenbaum
Childhood epilepsy is one of the most important and prevalent neurological conditions in the developing years. Persons with childhood onset epilepsy are at a high risk for poor psychosocial outcomes, even without experiencing co-morbidities. The goal of management of children with epilepsy should be to enable the child and the family to lead a life as free as possible from the medical and psychosocial complications of epilepsy. This comprehensive care needs to go beyond simply trying to control seizures with minimal adverse drug reactions...
2003: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/12681011/health-related-quality-of-life-in-children-with-epilepsy-development-and-validation-of-self-report-and-parent-proxy-measures
#20
Gabriel M Ronen, David L Streiner, Peter Rosenbaum
PURPOSE: To answer a need to include and measure accurately the impact and burden of epilepsy as outcomes of interventions with affected children, we developed and validated self-report and parent-proxy respondent health-related quality of life (HRQL) instruments for preadolescent children with epilepsy. METHODS: We combined qualitative and quantitative research methods. Items were extracted from focus group discussions involving children with epilepsy and their parents...
April 2003: Epilepsia
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