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Allergic rhinitis pregnancy

Qihong Deng, Chan Lu, Yichen Yu, Yuguo Li, Jan Sundell, Dan Norbäck
BACKGROUND: Evidence linking long-term exposure to outdoor air pollution with allergic rhinitis (AR) in children is scare, and the role of components of air pollution and timing of exposure remains unclear. OBJECTIVE: To assess the association of pre- and post-natal exposure to air pollution with life-time prevalence of AR in preschool children. METHODS: We conducted a cohort study of 2598 children aged 3-6 years in Changsha, China. The lifetime prevalence of AR was assessed by a questionnaire administered by parents...
December 2016: Respiratory Medicine
Tsutomu Tamada, Masakazu Ichinose
As one of the candidates of the therapeutic strategy for asthma in addition to inhaled corticosteroids (ICS), leukotriene receptor antagonists (LTRAs) are known to be useful for long-term management of asthma patients complicated by allergic rhinitis (AR) or exercise-induced asthma (EIA). Currently available LTRAs are pranlukast hydrate, zafirlukast, and montelukast. These LTRAs have a bronchodilator action and inhibit airway inflammation, resulting in a significant improvement of asthma symptoms, respiratory function, inhalation frequency of as-needed inhaled β2-agonist, airway inflammation, airway hyperresponsiveness, dosage of ICSs, asthma exacerbations, and patients' QOL...
November 9, 2016: Handbook of Experimental Pharmacology
Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao
BACKGROUND: Asthma is a global problem. Prevalence varies among different countries and cities. We aimed to obtain the prevalence, describe the characteristics, and discover factors that may relate to asthma in Hangzhou. METHODS: This cross-sectional study was conducted in Hangzhou. The subjects were children aged 14 years and younger. A control group of non-asthma children that matched in age and sex with each asthmatic patient was also randomly selected and interviewed...
September 27, 2016: Respiratory Research
Jakob Stokholm, Astrid Sevelsted, Ulrik D Anderson, Hans Bisgaard
Introduction Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. We studied associations between preeclampsia and asthma, allergy and eczema in Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and in national registries. Methods COPSAC2000 is a high-risk birth cohort of 411 Danish children. Asthma, allergy and eczema were diagnosed prospectively, and lung function measured at age 1mo and 7yrs. Sensitization was evaluated at age 6mo, 18mo, 4yrs and 6yrs by skin prick tests and IgE measurements...
September 14, 2016: American Journal of Respiratory and Critical Care Medicine
Hyeon-Jong Yang
Allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergy, are most common chronic, noncommunicable diseases in childhood. In the past few decades, the prevalence has increased abruptly worldwide. There are 2 possible explanations for the rising prevalence of allergic diseases worldwide, that an increased disease-awareness of physician, patient, or caregivers, and an abrupt exposure to unknown hazards. Unfortunately, the underlying mechanisms remain largely unknown. Despite the continuing efforts worldwide, the etiologies and rising prevalence remain unclear...
August 2016: Korean Journal of Pediatrics
Guo-Qiang Zhang, Bo Liu, Jun Li, Chun-Qi Luo, Qiao Zhang, Jin-Liang Chen, Anju Sinha, Zhong-Yue Li
It has been suggested that n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have anti-inflammatory properties and may reduce the risk of allergic disease. Fish is a great source of n-3 LC-PUFAs. However, the effect of fish on allergic disease remains controversial. PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) and prospective cohort studies regarding the effect of fish intake during pregnancy or infancy on allergic outcomes in children...
September 3, 2016: Pediatric Allergy and Immunology
M A Ryabova, N A Shumilova, O V Lavrova, L V Pestakova, Yu S Fedotova
The objective of the present study was to elucidate the causes responsible for a cough in the pregnant women. It involved 92 patients including 23 ones presenting with bronchial asthma and 69 having no manifestations of asthma in their medical histories but suffering from dry cough that started after the beginning of pregnancy. All the patients were given counseling by the otorhinolaryngology and pulmonology specialists. The degree of endoscopic manifestations of gastroesophageal reflux was estimated based on a scoring scale...
2016: Vestnik Otorinolaringologii
C Martins, J Lima, G Nunes, L M Borrego
BACKGROUND: Allergic asthma and rhinitis are common in pregnancy. The immune mechanisms underlying the effects of pregnancy in asthma and vice-versa are not completely understood. OBJECTIVES: This work aimed to study the evolution of regulatory T and B cells in asthmatic pregnant women, from late pregnancy till postpartum. METHODS: Four groups of women were enrolled for this study: third trimester pregnant women, asthmatic (n=24) and healthy (n=43), and non-pregnant women, asthmatic (n=33) and healthy (n=35)...
June 14, 2016: Journal of Investigational Allergology & Clinical Immunology
Qihong Deng, Chan Lu, Yuguo Li, Jan Sundell, Dan Norbäck
BACKGROUND: Mounting evidence suggests that exposure to ambient air pollution is associated with the development of childhood allergic diseases, but the effect of prenatal exposure to air pollution on the risk of childhood asthma and allergy is unclear. OBJECTIVES: We evaluated the association between maternal exposure to outdoor air pollution during different trimesters of pregnancy and incidence of asthma, allergic rhinitis, and eczema in 2598 preschool children aged 3-6 years in China...
October 2016: Environmental Research
Susanne Hansen, Marin Strøm, Ekaterina Maslova, Ronald Dahl, Hans Jürgen Hoffmann, Dorte Rytter, Bodil Hammer Bech, Tine Brink Henriksen, Charlotta Granström, Thorhallur I Halldorsson, Jorge E Chavarro, Allan Linneberg, Sjurdur F Olsen
BACKGROUND: Maternal supplementation with long-chain n-3 polyunsaturated fatty acids can have immunologic effects on the developing fetus through several anti-inflammatory pathways. However, there is limited knowledge of the long-term programming effects. OBJECTIVE: In a randomized controlled trial from 1990 with 24 years of follow-up, our aim was to determine whether supplementation with 2.7 g of long-chain n-3 polyunsaturated fatty acids in pregnancy can reduce the risk of asthma in offspring and allergic respiratory disease...
April 25, 2016: Journal of Allergy and Clinical Immunology
Karen P Best, Thomas Sullivan, Debra Palmer, Michael Gold, Declan John Kennedy, James Martin, Maria Makrides
BACKGROUND AND OBJECTIVE: Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy. METHODS: Six-year follow-up of children (n = 706) with a family history of allergic disease from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial...
June 2016: Pediatrics
Vivian Chia-Rong Hsieh, Chin-Chen Liu, Yu-Chen Hsiao, Trong-Neng Wu
PURPOSE: Despite links between maternal and child health status, evidence on the association between gum infection in pregnant mothers and childhood allergies is scarce. We aim to evaluate the risk of developing allergy in children born to periodontal mothers in a nationwide study. METHODS: We conducted a 9-year population-based, retrospective cohort study using Taiwan's National Health Insurance database. A study cohort of 42,217 newborns born to mothers with periodontal disease during pregnancy was identified in 2001 and matched with 42,334 babies born to mothers without any infection (control) by mother's age at delivery and baby sex...
2016: PloS One
(no author information available yet)
During pregnancy, the first-choice drugs for allergic rhinitis are nasal or oral "non-sedating" antihistamines without antimuscarinic activity, in particular cetirizine, or loratadine after the first trimester.
April 2016: Prescrire International
E Ridolo, M Caminati, I Martignago, V Melli, C Salvottini, O Rossi, A Dama, M Schiappoli, C Bovo, C Incorvaia, G Senna
INTRODUCTION: Allergic rhinitis (AR) affects 20-30% of women in reproductive age and may worsen during pregnancy. About 10% of the elderly suffer from AR, and it could be under-diagnosed in these patients. Many drugs are currently available, however AR treatment during pregnancy and old age represents a challenging issue. AREAS COVERED: A review of the literature on the topic has been performed. Expert commentary: In pregnancy, drug avoidance should be carefully balanced with the need for AR optimal control...
August 2016: Expert Review of Clinical Pharmacology
Ludger Klimek, Annette Sperl
If the avoidance of the provoking allergen is insufficient or not possible, medical treatment can be tried. Therapeutics of the first choice for the treatment of the seasonal and persistent allergic rhinitis are antihistamines and topical glucocorticoids. Chromones are less effective so they should only be used for adults with a special indication, for example during pregnancy. Beside the avoidance of the allergen the immunotherapy is the only causal treatment of allergic diseases.
March 2016: Medizinische Monatsschrift Für Pharmazeuten
Johan Alm, Emma Goksör
Asthma, eczema, food allergy and allergic rhinitis are common and the cause is still largely unknown, but it is the subject of extensive research. The research results are inconclusive, probably due to individual differences in vulnerability to different exposures and to a highly multifactorial origin. Several environmental factors have been identified as risk factors or as having a potentially protective effect. Smoking during pregnancy or childhood increases the risk of obstructive symptoms and asthma. Breastfeeding reduces the risk of infectious diseases and thereby also the risk of early obstructive symptoms...
2016: Läkartidningen
Kiwako Yamamoto-Hanada, Masaki Futamura, Limin Yang, Tetsuo Shoda, Masami Narita, Fumio Kobayashi, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: The prevalence of maternal oral contraceptive pills (OCP) use and that of childhood asthma are high in western countries. The aim of this study is to examine the association of OCP use with childhood wheeze and allergic diseases in Japan. METHODS: Relevant data were extracted from a hospital based birth cohort study named as Tokyo-Children's Health, Illness and Development Study (T-CHILD) of which questionnaire conducted during pregnancy included maternal history and duration of OCP use...
July 2016: Allergology International: Official Journal of the Japanese Society of Allergology
Jai Namazy, M Schatz
Pregnancy may be complicated by new-onset or preexisting asthma and allergic rhinitis.This article reviews the recognition and management of asthma and allergic rhinitis during pregnancy, paying close attention to the general principles of allergy and use of asthma medication during pregnancy. Both allergic rhinitis and asthma can adversely affect both maternal quality of life and, in the case of maternal asthma, perinatal outcomes. Optimal management is thus important for both mother and baby. This article reviews the safety of asthma and allergy medications commonly used during pregnancy...
2016: Journal of Investigational Allergology & Clinical Immunology
Supinda Bunyavanich, Sheryl L Rifas-Shiman, Thomas A Platts-Mills, Lisa Workman, Joanne E Sordillo, Carlos A Camargo, Matthew W Gillman, Diane R Gold, Augusto A Litonjua
BACKGROUND: The role of early-life vitamin D in childhood allergy is controversial. OBJECTIVE: We sought to assess vitamin D exposure in early life by multiple modalities and ascertain its association with childhood allergic rhinitis and allergic sensitization. METHODS: One thousand two hundred forty-eight mother-child pairs from a US prebirth cohort unselected for any disease were studied. Vitamin D exposure was assessed by measures of maternal intake during the first and second trimesters of pregnancy and serum 25-hydroxyvitamin D (25[OH]D) levels in mothers during pregnancy, cord blood, and children at school age (median age, 7...
April 2016: Journal of Allergy and Clinical Immunology
A-M M Schoos, B L Chawes, E Jelding-Dannemand, L B Elfman, H Bisgaard
RATIONALE: Allergen exposure is associated with the development of allergic sensitization in childhood as reflected by global variations in sensitization patterns. However, there is little evidence to support a direct association. OBJECTIVES: To investigate the association between perinatal aeroallergen exposure and sensitization and rhinitis to such allergens later in childhood. METHODS: Allergic sensitization to cat, dog, and house dust mites was diagnosed longitudinally using skin prick tests and specific IgE measurements at ½, 1½, 4, 6, and 13 years in 399 children from the Copenhagen Prospective Study on Asthma in Childhood2000 birth cohort...
May 2016: Allergy
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