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JOURNAL ARTICLE
Yao Lu, Yaqiong He, Yuan Wang, Qinling Zhu, Jia Qi, Xinyu Li, Ying Ding, Jiaan Huang, Ziyin Ding, Yurui Xu, Yanan Yang, Steven R Lindheim, Zhe Wei, Yun Sun
STUDY QUESTION: Does severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the frozen-thawed embryo transfer (FET) cycle affect embryo implantation and pregnancy rates? SUMMARY ANSWER: There is no evidence that SARS-CoV-2 infection of women during the FET cycle negatively affects embryo implantation and pregnancy rates. WHAT IS KNOWN ALREADY: Coronavirus disease 2019 (COVID-19), as a multi-systemic disease, poses a threat to reproductive health...
April 11, 2024: Human Reproduction
#22
JOURNAL ARTICLE
(no author information available yet)
Embryonic diapause can be induced by nutrient deprivation, but the molecular mechanisms underpinning this process are unclear. A new paper in Development shows that protein and carbohydrate depletion can trigger embryonic diapause via the nutrient sensors Gator1 and Tsc2. To learn more about the story behind the paper, we caught up with first author Jiajia Ye and corresponding author Qiang Sun, professor and director of the Non-Human Primate Research Facility at the Institute of Neuroscience, Chinese Academy of Sciences...
April 1, 2024: Development
#23
JOURNAL ARTICLE
Jiajia Ye, Yuting Xu, Qi Ren, Lu Liu, Qiang Sun
Embryonic diapause is a special reproductive phenomenon in mammals that helps embryos to survive various harsh stresses. However, the mechanisms of embryonic diapause induced by the maternal environment is still unclear. Here, we uncovered that nutrient deficiency in uterine fluid was essential for the induction of mouse embryonic diapause, shown by a decreased concentration of arginine, leucine, isoleucine, lysine, glucose and lactate in the uterine fluid of mice suffering from maternal starvation or ovariectomy...
April 1, 2024: Development
#24
JOURNAL ARTICLE
Xiaotian Feng, Helen Molteni, Megan Gregory, Jennifer Lanza, Nikaya Polsani, Isha Gupta, Rachel Wyetzner, M Brent Hawkins, Greg Holmes, Sevan Hopyan, Matthew P Harris, Radhika P Atit
The skull roof, or calvaria, is comprised of interlocking plates of bones that encase the brain. Separating these bones are fibrous sutures that permit growth. Currently, we do not understand the instructions for directional growth of the calvaria, a process which is error-prone and can lead to skeletal deficiencies or premature suture fusion (craniosynostosis, CS). Here, we identify graded expression of fibronectin (FN1) in the mouse embryonic cranial mesenchyme (CM) that precedes the apical expansion of calvaria...
April 1, 2024: Development
#25
JOURNAL ARTICLE
Xiaochao Wei, Xiuge Wang, Chunhong Yang, Yaping Gao, Yaran Zhang, Yao Xiao, Zhihua Ju, Qiang Jiang, Jinpeng Wang, Wenhao Liu, Yanqin Li, Yundong Gao, Jinming Huang
CFAP58 is a testis-enriched gene that plays an important role in the sperm flagellogenesis of humans and mice. However, the effect of CFAP58 on bull semen quality and the underlying molecular mechanisms involved in spermatogenesis remain unknown. Here, we identified two single-nucleotide polymorphisms (rs110610797, A>G and rs133760846, G>T) and one indel (g.-1811_ g.-1810 ins147bp) in the promoter of CFAP58 that were significantly associated with semen quality of bulls, including sperm deformity rate and ejaculate volume...
April 1, 2024: Development
#26
JOURNAL ARTICLE
Fatima N Chaudhry, Nigel S Michki, Dain L Shirmer, Sharon Mcgrath-Morrow, Lisa R Young, David B Frank, Jarod A Zepp
Alveologenesis, the final stage in lung development, substantially remodels the distal lung, expanding the alveolar surface area for efficient gas exchange. Secondary crest myofibroblasts (SCMF) exist transiently in the neonatal distal lung and are critical for alveologenesis. However, the pathways that regulate SCMF function, proliferation, and temporal identity remain poorly understood. To address this, we purified SCMFs from reporter mice, performed bulk RNA-sequencing, and found dynamic changes in Hippo-signaling components during alveologenesis...
April 5, 2024: Development
#27
JOURNAL ARTICLE
Yongjun Yin, Jeffrey R Koenitzer, Debabrata Patra, Sabine Dietmann, Peter Bayguinov, Andrew S Hagan, David M Ornitz
Alveologenesis is the final stage of lung development in which the internal surface area of the lung is increased to facilitate efficient gas exchange in the mature organism. The first phase of alveologenesis involves the formation of septal ridges (secondary septae) and the second phase involves thinning of the alveolar septa. Within secondary septa, mesenchymal cells include a transient population of alveolar myofibroblasts (MyoFB) and a stable but poorly described population of lipid rich cells that have been referred to as lipofibroblasts or matrix fibroblasts (MatFB)...
April 11, 2024: Development
#28
JOURNAL ARTICLE
Haisu Zhou, Chengshuang Pan, Yonggen Wu, Danna Ye, Qianjin Fei, Xiangbin Kong, Huan Zhang, Wumin Jin
This study aims to compare the embryological and clinical parameters of intracytoplasmic sperm injection (ICSI) cycles using testicular versus ejaculated sperm in male patients with elevated sperm DNA fragmentation (SDF). A total of 73 ICSI cycles were examined in couples where the male partner exhibited high levels of SDF. ICSI was performed using either ejaculated or testicular sperm. The primary outcomes were rates of blastocyst formation, high-quality embryo development, and clinical pregnancy. The DNA fragmentation index (DFI) for testicular sperm (16...
December 2024: Human Fertility: Journal of the British Fertility Society
#29
JOURNAL ARTICLE
Danah Kamphuis, Rik van Eekelen, Nienke van Welie, Kim Dreyer, Joukje van Rijswijk, Machiel H A van Hooff, Jan Peter de Bruin, Harold R Verhoeve, Femke Mol, Wilhelmina M van Baal, Maaike A F Traas, Arno M van Peperstraten, Arentje P Manger, Judith Gianotten, Cornelia H de Koning, Aafke M H Koning, Neriman Bayram, David P van der Ham, Francisca P J M Vrouenraets, Michaela Kalafusova, Bob I G van de Laar, Jeroen Kaijser, Arjon F Lambeek, Wouter J Meijer, Frank J M Broekmans, Olivier Valkenburg, Lucy F van der Voet, Jeroen van Disseldorp, Marieke J Lambers, Rachel Tros, Cornelis B Lambalk, Jaap Stoker, Madelon van Wely, Patrick M M Bossuyt, Ben Willem J Mol, Velja Mijatovic
STUDY QUESTION: What are the costs and effects of tubal patency testing by hysterosalpingo-foam sonography (HyFoSy) compared to hysterosalpingography (HSG) in infertile women during the fertility work-up? SUMMARY ANSWER: During the fertility work-up, clinical management based on the test results of HyFoSy leads to slightly lower, though not statistically significant, live birth rates, at lower costs, compared to management based on HSG results. WHAT IS KNOWN ALREADY: Traditionally, tubal patency testing during the fertility work-up is performed by HSG...
April 10, 2024: Human Reproduction
#30
JOURNAL ARTICLE
Camille Vatier, Sophie Christin-Maitre
Polycystic ovary syndrome (PCOS) affects 6-20% of reproductive-aged women. It is associated with increased risks of metabolic syndrome, Type 2 diabetes, cardiovascular diseases, mood disorders, endometrial cancer and non-alcoholic fatty liver disease. Although various susceptibility loci have been identified through genetic studies, they account for ∼10% of PCOS heritability. Therefore, the etiology of PCOS remains unclear. This review explores the role of epigenetic changes and modifications in circadian clock genes as potential contributors to PCOS pathogenesis...
April 10, 2024: Human Reproduction
#31
JOURNAL ARTICLE
Ping Cao, Josien Derhaag, Edith Coonen, Han Brunner, Ganesh Acharya, Andres Salumets, Masoud Zamani Esteki
STUDY QUESTION: Can generative artificial intelligence (AI) models produce high-fidelity images of human blastocysts? SUMMARY ANSWER: Generative AI models exhibit the capability to generate high-fidelity human blastocyst images, thereby providing substantial training datasets crucial for the development of robust AI models. WHAT IS KNOWN ALREADY: The integration of AI into IVF procedures holds the potential to enhance objectivity and automate embryo selection for transfer...
April 10, 2024: Human Reproduction
#32
JOURNAL ARTICLE
Pooja Raval, Kashmira Khaire, Shashikant Sharma, Suresh Balakrishnan
The northern house gecko Hemidactylus flaviviridis exhibits appendage-specific responses to injuries. The autotomized tail regenerates, whereas the severed limb fails to regrow. Many site-specific cellular processes influence tail regeneration. Herein, we analyzed the epithelial-mesenchymal transition contrast in the lizard's amputated appendages (tail and limb). Morphological observations in the healing frame indicated the formation of regeneration blastema in the tail and scar formation in limb. Histology of the tail showed that epithelial cells closer to mesenchyme appeared less columnar and loosely packed, with little intercellular matrix...
April 10, 2024: Development, Growth & Differentiation
#33
JOURNAL ARTICLE
(no author information available yet)
The mitotic kinase Aurora A has been shown to regulate the anterior-posterior polarity in developing Caenorhabditis elegans embryos. In a new study, Daniel Dickinson and colleagues find that Aurora A has temporally distinct roles in coordinating the localization of Partitioning defective (PAR) proteins to establish cell polarity during development. To find out more about the story behind the paper, we caught up with first author Nadia Manzi and corresponding author Daniel Dickinson, Assistant Professor at the University of Texas at Austin...
April 1, 2024: Development
#34
JOURNAL ARTICLE
Zoran J Pavlovic, Victoria S Jiang, Eduardo Hariton
PURPOSE OF REVIEW: This review highlights the timely relevance of artificial intelligence in enhancing assisted reproductive technologies (ARTs), particularly in-vitro fertilization (IVF). It underscores artificial intelligence's potential in revolutionizing patient outcomes and operational efficiency by addressing challenges in fertility diagnoses and procedures. RECENT FINDINGS: Recent advancements in artificial intelligence, including machine learning and predictive modeling, are making significant strides in optimizing IVF processes such as medication dosing, scheduling, and embryological assessments...
April 2, 2024: Current Opinion in Obstetrics & Gynecology
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JOURNAL ARTICLE
Chizuru Umeda, Koichi Ueda, Yuka Hirota
BACKGROUND: Postaxial polydactyly is a common congenital foot anomaly. However, the severity of the anomaly varies from simple cases with only soft tissue duplication to complex cases with bone and joint disorders. In our clinical practice, we found a new morphological anomaly of postaxial polydactyly. We encountered several cases of postaxial polydactyly with bone fragments located between the fourth and fifth toes. The bone fragments were independent of the joint cavity. The mechanisms underlying its development remain unknown because it is a novel disorder...
April 2024: Plastic and Reconstructive Surgery. Global Open
#36
JOURNAL ARTICLE
Yan Guo, Xiaomei Wang, Yang Gao, Haiyan Yin, Qun Ma, Ting Chen
BACKGROUND: Flexible hybrid teaching has become the new normal of basic medical education in the postepidemic era. Identifying ways to improve the quality of curriculum teaching and achieve high-level talent training is a complex problem that urgently needs to be solved. Over the course of the past several semesters, the research team has integrated design thinking (DT) into undergraduate teaching to identify, redesign and solve complex problems in achieving curriculum teaching and professional talent training objectives...
April 9, 2024: BMC Medical Education
#37
JOURNAL ARTICLE
Claudia Massarotti, Omar F Ammar, George Liperis, Mina Mincheva, Juan J Fraire-Zamora, Kashish Sharma, Roseanne Rosario, Amy L Winship, Matteo Lambertini, Sofia Makieva
No abstract text is available yet for this article.
April 9, 2024: Human Reproduction
#38
JOURNAL ARTICLE
Johan Paulin, Kimmo Sorjonen, Gunilla Sydsjö, Claudia Lampic
STUDY QUESTION: Can the application of the theory of planned behavior (TPB) help predict heterosexual parents' disclosure of donor conception to their children? SUMMARY ANSWER: Parents with a stronger will to act in accordance with social norms favoring disclosure were more likely to start the disclosure process within the next 5-9 years. WHAT IS KNOWN ALREADY: In contrast to single mothers by choice and same-sex couples, heterosexual couples need to make an active decision to disclose their use of donor conception to their child...
April 9, 2024: Human Reproduction
#39
REVIEW
Ai Fang, C Ron Yu
Neural activity influences every aspect of nervous system development. In olfactory systems, sensory neurons expressing the same odorant receptor project their axons to stereotypically positioned glomeruli, forming a spatial map of odorant receptors in the olfactory bulb. As individual odors activate unique combinations of glomeruli, this map forms the basis for encoding olfactory information. The establishment of this stereotypical olfactory map requires coordinated regulation of axon guidance molecules instructed by spontaneous activity...
February 2024: Genesis: the Journal of Genetics and Development
#40
JOURNAL ARTICLE
Lu Li, Xingyu Bi, Xueqing Wu, Zhongrong Chen, Yunxia Cao, Gang Zhao
STUDY QUESTION: Can the addition of late embryogenesis-abundant (LEA) proteins as a cryoprotective agent during the vitrification cryopreservation of in vitro matured oocytes enhance their developmental potential after fertilization? SUMMARY ANSWER: LEA proteins improve the developmental potential of human in vitro matured oocytes following cryopreservation, mostly by downregulating FOS genes, reducing oxidative stress, and inhibiting the formation of ice crystals...
April 9, 2024: Human Reproduction
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