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PTSD genetics

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https://www.readbyqxmd.com/read/29150144/atypical-depression-and-non-atypical-depression-is-hpa-axis-function-a-biomarker-a-systematic-review
#1
REVIEW
Mario F Juruena, Mariia Bocharova, Bruno Agustini, Allan H Young
BACKGROUND: The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29082582/problematic-alcohol-use-associates-with-sodium-channel-and-clathrin-linker-1-sclt1-in-trauma-exposed-populations
#2
Lynn M Almli, Adriana Lori, Jacquelyn L Meyers, Jaemin Shin, Negar Fani, Adam X Maihofer, Caroline M Nievergelt, Alicia K Smith, Kristina B Mercer, Kimberly Kerley, Jennifer M Leveille, Hao Feng, Duna Abu-Amara, Janine D Flory, Rachel Yehuda, Charles R Marmar, Dewleen G Baker, Bekh Bradley, Karestan C Koenen, Karen N Conneely, Kerry J Ressler
Excessive alcohol use is extremely prevalent in the United States, particularly among trauma-exposed individuals. While several studies have examined genetic influences on alcohol use and related problems, this has not been studied in the context of trauma-exposed populations. We report results from a genome-wide association study of alcohol consumption and associated problems as measured by the alcohol use disorders identification test (AUDIT) in a trauma-exposed cohort. Results indicate a genome-wide significant association between total AUDIT score and rs1433375 [N = 1036, P = 2...
October 30, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29081351/integrating-biological-treatment-mechanisms-into-randomized-clinical-trials-design-of-progress-prolonged-exposure-and-sertraline-trial
#3
Sheila A M Rauch, Naomi M Simon, H Myra Kim, Ron Acierno, Anthony P King, Sonya B Norman, Margaret R Venners, Katherine Porter, K Luan Phan, Peter W Tuerk, Carolyn Allard, Israel Liberzon, Barbara O Rothbaum, Brian Martis, Murray B Stein, Charles W Hoge
Increased emphasis on mechanisms of treatment effectiveness, biomarker predictors, and objective indicators of treatment response has sparked interest in integrated, translational treatment outcomes trials. The PROlonGed ExpoSure and Sertraline Trial (PROGrESS) is one such randomized controlled trial (RCT) focused on a key question in clinical management of posttraumatic stress disorder (PTSD) - the comparative and combined effectiveness of medication and psychotherapy. PROGrESS employs a state of the art trial design to examine psychotherapy and medication effects across three conditions: 1) Prolonged Exposure (PE) plus pill placebo, 2) Sertraline (SERT) plus Enhanced Medication Management (EMM), and 3) Combined treatment (PE/SERT)...
October 29, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29054677/expression-of-the-ppm1f-gene-is-regulated-by-stress-and-associated-with-anxiety-and-depression
#4
Aliza P Wingo, Eric R Velasco, Antonio Florido, Adriana Lori, Dennis C Choi, Tanja Jovanovic, Kerry J Ressler, Raül Andero
BACKGROUND: Molecular mechanisms underlying psychological sequelae of exposure to stressful experiences, such as posttraumatic stress disorder (PTSD) and depression, are not well understood. METHODS: Using convergent evidence from animal and human transcriptomic and genomic studies, we aimed to identify genetic mechanisms underlying depression and anxiety after traumatic experiences. RESULTS: From a transcriptome-wide analysis in mice, we found the Ppm1f gene to be differentially expressed in the amygdala and medial prefrontal cortex (mPFC) a week after immobilization stress...
August 30, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28965303/impact-of-gender-on-child-and-adolescent-ptsd
#5
REVIEW
Kristie Garza, Tanja Jovanovic
PURPOSE OF REVIEW: This review examines the recent literature on biological factors that influence sex differences in posttraumatic stress disorder (PTSD) during childhood and adolescence, focusing on neurobiological, hormonal, and genetic factors that may increase risk in girls. RECENT FINDINGS: More than 60% of children and adolescents are exposed to traumatic events, and many develop PTSD. There is increasing recognition of gender differences in PTSD, with women having double the rates of the disorder compared to men...
September 30, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28942195/short-overview-on-metabolomic-approach-and-redox-changes-in-psychiatric-disorders
#6
REVIEW
Gordana Nedic Erjavec, Marcela Konjevod, Matea Nikolac Perkovic, Dubravka Svob Strac, Lucija Tudor, Coral Barbas, Tilman Grune, Neven Zarkovic, Nela Pivac
Schizophrenia, depression and posttraumatic stress disorder (PTSD) are severe mental disorders and complicated diagnostic entities, due to their phenotypic, biological and genetic heterogeneity, unknown etiology, and poorly understood alterations in biological pathways and biological mechanisms. Disturbed homeostasis between overproduction of oxidant species, overcoming redox regulation and a lack of cellular antioxidant defenses, resulting in free radical-mediated pathology and subsequent neurotoxicity contributes to development of depression, schizophrenia and PTSD, their heterogeneous clinical presentation and resistance to treatment...
September 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28888533/an-overview-of-posttraumatic-stress-disorder-genetic-studies-by-analyzing-and-integrating-genetic-data-into-genetic-database-ptsdgene
#7
REVIEW
Kunlin Zhang, Susu Qu, Suhua Chang, Gen Li, Chengqi Cao, Kechi Fang, Miranda Olff, Li Wang, Jing Wang
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric syndrome with complex etiology. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing. However, the results are limited and highly heterogeneous. To understand the genetic study status of PTSD and explore more reliable candidates, we obtained 105 PTSD related genetic studies by comprehensively literature searching and filtering 1762 studies. Detailed phenotype and sample information for each study and association results for each genetic marker were extracted...
September 6, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28867284/crp-polymorphisms-and-dna-methylation-of-the-aim2-gene-influence-associations-between-trauma-exposure-ptsd-and-c-reactive-protein
#8
M W Miller, H Maniates, E J Wolf, M W Logue, S A Schichman, A Stone, W Milberg, R McGlinchey
BACKGROUND: Recent studies have implicated inflammatory processes in the pathophysiology of posttraumatic stress disorder (PTSD). C-reactive protein (CRP) is a widely-used measure of peripheral inflammation, but little is known about the genetic and epigenetic factors that influence blood levels of C-reactive protein (CRP) in individuals with PTSD. METHODS: Participants were 286 U.S. military veterans of post-9/11 conflicts (57% with current PTSD). Analyses focused on single nucleotide polymorphisms (SNPs) in the CRP gene and DNA methylation at cg10636246 in AIM2-a locus recently linked to CRP levels through results from a large-scale epigenome-wide association study...
August 31, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28813320/the-genetics-and-epigenetics-of-ptsd-overview-recent-advances-and-future-directions
#9
REVIEW
Christina M Sheerin, Mackenzie J Lind, Kaitlin E Bountress, Nicole R Nugent, Ananda B Amstadter
This paper provides a brief summary and commentary on the growing literature and current developments related to the genetic underpinnings of posttraumatic stress disorder (PTSD). We first briefly provide an overview of the behavioral genetic literature on PTSD, followed by a short synopsis of the substantial candidate gene literature with a focus on genes that have been meta-analyzed. We then discuss the genome-wide association studies (GWAS) that have been conducted, followed by an introduction to other molecular platforms used in PTSD genomic studies, such as epigenetic and expression approaches...
April 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28768717/formin-2-links-neuropsychiatric-phenotypes-at-young-age-to-an-increased-risk-for-dementia
#10
Roberto Carlos Agís-Balboa, Paulo S Pinheiro, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahari-Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer, Farahnaz Sananbenesi
Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer's disease (AD) patients. Young mice lacking the Fmn2 gene exhibit PTSD-like phenotypes and corresponding impairments of synaptic plasticity, while the consolidation of new memories is unaffected...
October 2, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28746747/association-of-posttraumatic-stress-disorder-with-rs2267735-in-the-adcyap1r1-gene-a-meta-analysis
#11
Mackenzie J Lind, Marisa E Marraccini, Christina M Sheerin, Kaitlin Bountress, Silviu-Alin Bacanu, Ananda B Amstadter, Nicole R Nugent
Recent studies point to the potential role of the (pituitary) adenylate cyclase activating polypeptide receptor 1 (ADCYAP1R1) gene, which has been implicated in stress response, in posttraumatic stress disorder (PTSD). Multiple genetic association studies have examined potential PTSD risk related to this gene, with mixed results. We conducted a meta-analysis of rs2267735 in ADCYAP1R1 in PTSD. A literature search was conducted using PubMed and PsycINFO, resulting in nine studies that met criteria for inclusion in analysis...
August 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28686326/single-nucleotide-polymorphisms-in-genes-related-to-the-hypothalamic-pituitary-adrenal-axis-as-risk-factors-for-posttraumatic-stress-disorder
#12
REVIEW
Carolina M Carvalho, Bruno M Coimbra, Vanessa K Ota, Marcelo F Mello, Sintia I Belangero
Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is strongly correlated with this disorder. One hypothesis is that HPA axis dysfunction may precede the traumatic event, suggesting that genes expressed in the HPA axis may be involved in the development of PTSD...
July 7, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28681202/genetic-variability-of-interleukin-1-beta-as-prospective-factor-from-developing-post-traumatic-stress-disorder
#13
Lilit Hovhannisyan, Ani Stepanyan, Arsen Arakelyan
Individual susceptibility to post-traumatic stress disorder (PTSD) is conditioned by genetic factors, and association between this disorder and polymorphisms of several genes have been shown. The aim of this study was to explore a potential association between single nucleotide polymorphisms (SNP) of the IL-1β gene (IL1B) and PTSD. In genomic DNA samples of PTSD-affected and healthy subjects, the rs16944, rs1143634, rs2853550, rs1143643, and rs1143633 SNPs of IL1B gene have been genotyped. The results obtained demonstrated that IL1B rs1143633*C and rs16944*A minor allele frequency were significantly lower in patients than in controls...
July 5, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28675393/erbb4-signaling-in-the-prelimbic-cortex-regulates-fear-expression
#14
Y-H Chen, Y-J Lan, S-R Zhang, W-P Li, Z-Y Luo, S Lin, J-P Zhuang, X-W Li, S-J Li, J-M Yang, T-M Gao
Many psychiatric diseases such as post-traumatic stress disorder (PTSD) are characterized by abnormal processing of emotional stimuli particularly fear. The medial prefrontal cortex (mPFC) is critically involved in fear expression. However, the molecular mechanisms underlying this process are largely unknown. Neuregulin-1 (NRG1) reportedly regulates pyramidal neuronal activity via ErbB4 receptors, which are abundant in parvalbumin (PV)-expressing interneurons in the PFC. In this study, we aimed to determine how NRG1/ErbB4 signaling in the mPFC modulates fear expression and found that tone-cued fear conditioning increased NRG1 expression in the mPFC...
July 4, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28594439/genetic-and-psychosocial-predictors-of-alcohol-use-trajectories-among-disaster-exposed-adolescents
#15
Kaitlin Bountress, Carla Kmett Danielson, Vernell Williamson, Vladimir Vladmirov, Joel Gelernter, Kenneth Ruggiero, Ananda Amstadter
BACKGROUND AND OBJECTIVES: Adolescent alcohol misuse is associated with numerous long-term adverse outcomes, so we examined predictors of alcohol use among disaster-exposed adolescents, a group at-risk for alcohol misuse. METHODS: The current study (n = 332) examined severity of tornado-related exposure, posttraumatic stress disorder (PTSD) symptoms, emotional support, and a genetic risk sum score (GRSS) as predictors of alcohol use trajectories. RESULTS: Severity of exposure interacted with the GRSS to predict both intercept (12-month follow up quantity of alcohol use) and growth rate...
September 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28579519/contributions-of-polygenic-risk-for-obesity-to-ptsd-related-metabolic-syndrome-and-cortical-thickness
#16
Erika J Wolf, Danielle R Miller, Mark W Logue, Jennifer Sumner, Tawni B Stoop, Elizabeth C Leritz, Jasmeet P Hayes, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Research suggests that posttraumatic stress disorder (PTSD) is associated with metabolic syndrome (MetS) and that PTSD-associated MetS is related to decreased cortical thickness. However, the role of genetic factors in these associations is unclear. This study evaluated contributions of polygenic obesity risk and PTSD to MetS and of MetS and polygenic obesity risk to cortical thickness. METHODS: 196 white, non-Hispanic veterans of the wars in Iraq and Afghanistan underwent clinical diagnostic interviews, physiological assessments, and genome-wide genotyping; 168 also completed magnetic resonance imaging scans...
October 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28555114/attitudes-about-future-genetic-testing-for-posttraumatic-stress-disorder-and-addiction-among-community-based-veterans
#17
Michelle R Lent, Stuart N Hoffman, H Lester Kirchner, Thomas G Urosevich, Joseph J Boscarino, Joseph A Boscarino
This study explored attitudes toward hypothetical genetic testing for posttraumatic stress disorder (PTSD) and addiction among veterans. We surveyed a random sample of community-based veterans (n = 700) by telephone. One year later, we asked the veterans to provide a DNA sample for analysis and 41.9% of them returned the DNA samples. Overall, most veterans were not interested in genetic testing neither for PTSD (61.7%) nor for addiction (68.7%). However, bivariate analyses suggested there was an association between having the condition of interest and the likelihood of genetic testing on a 5-point scale (p < 0...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28508360/genome-to-phenome-a-systems-biology-approach-to-ptsd-using-an-animal-model
#18
Nabarun Chakraborty, James Meyerhoff, Marti Jett, Rasha Hammamieh
Post-traumatic stress disorder (PTSD) is a debilitating illness that imposes significant emotional and financial burdens on military families. The understanding of PTSD etiology remains elusive; nonetheless, it is clear that PTSD is manifested by a cluster of symptoms including hyperarousal, reexperiencing of traumatic events, and avoidance of trauma reminders. With these characteristics in mind, several rodent models have been developed eliciting PTSD-like features. Animal models with social dimensions are of particular interest, since the social context plays a major role in the development and manifestation of PTSD...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28494120/posttraumatic-stress-disorder-symptom-severity-is-associated-with-reduced-default-mode-network-connectivity-in-individuals-with-elevated-genetic-risk-for-psychopathology
#19
Danielle R Miller, Mark W Logue, Erika J Wolf, Hannah Maniates, Meghan E Robinson, Jasmeet P Hayes, Annjanette Stone, Steven Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship between DMN connectivity and PTSD. In this study, we investigated this possibility using genome-wide association study (GWAS) derived polygenic risk scores (PRSs) for relevant psychiatric traits...
July 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28439101/largest-gwas-of-ptsd-n-20%C3%A2-070-yields-genetic-overlap-with-schizophrenia-and-sex-differences-in-heritability
#20
L E Duncan, A Ratanatharathorn, A E Aiello, L M Almli, A B Amstadter, A E Ashley-Koch, D G Baker, J C Beckham, L J Bierut, J Bisson, B Bradley, C-Y Chen, S Dalvie, L A Farrer, S Galea, M E Garrett, J E Gelernter, G Guffanti, M A Hauser, E O Johnson, R C Kessler, N A Kimbrel, A King, N Koen, H R Kranzler, M W Logue, A X Maihofer, A R Martin, M W Miller, R A Morey, N R Nugent, J P Rice, S Ripke, A L Roberts, N L Saccone, J W Smoller, D J Stein, M B Stein, J A Sumner, M Uddin, R J Ursano, D E Wildman, R Yehuda, H Zhao, M J Daly, I Liberzon, K J Ressler, C M Nievergelt, K C Koenen
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h(2)SNP) for European-American females of 29% that is similar to h(2)SNP for schizophrenia and is substantially higher than h(2)SNP in European-American males (estimate not distinguishable from zero)...
April 25, 2017: Molecular Psychiatry
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