keyword
MENU ▼
Read by QxMD icon Read
search

PTSD genetics

keyword
https://www.readbyqxmd.com/read/28293323/effect-of-sanitary-environmental-conditions-of-diabetic-hypertension-incidence-in-displaced-persons
#1
Muamer Muraspahić, Isaja Kastrat, Semsudin Plojović, Mirsad Imamovic, Sonja Ketin, Rade Biocanin
BACKGROUND: The abnormal conditions of life and genetic factors often play a major role in the incidence of "diabetes - diabetes", heart disease and vascular disease, jaundice and posttraumatic stress. AIM: Trauma and posttraumatic stress are most common in the displaced persons, and the focus of this paper is to focus on this issue regarding cases in former Yugoslavia, and now in our country. These diseases are caused by increased beta-cell sensitivity to viruses, the development of autoimmune antibodies attacking their pancreas cells, degenerative changes in cells that result in the change of structure and of insulin production...
March 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28273291/an-integrated-neuroscience-perspective-on-formulation-and-treatment-planning-for-posttraumatic-stress-disorder-an-educational-review
#2
David A Ross, Melissa R Arbuckle, Michael J Travis, Jennifer B Dwyer, Gerrit I van Schalkwyk, Kerry J Ressler
Importance: Posttraumatic stress disorder (PTSD) is a common psychiatric illness, increasingly in the public spotlight in the United States due its prevalence in the soldiers returning from combat in Iraq and Afghanistan. This educational review presents a contemporary approach for how to incorporate a modern neuroscience perspective into an integrative case formulation. The article is organized around key neuroscience "themes" most relevant for PTSD. Within each theme, the article highlights how seemingly diverse biological, psychological, and social perspectives all intersect with our current understanding of neuroscience...
March 8, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28262266/ptsd-in-court-ii-risk-factors-endophenotypes-and-biological-underpinnings-in-ptsd
#3
REVIEW
Gerald Young
The second article in the series of three for the journal on "PTSD in Court" especially concerns the biological bases that have been found to be associated with PTSD (posttraumatic stress disorder). The cohering concepts in this section relate to risk factors; candidate genes; polygenetics; "gene×environment" interactions; epigenetics; endophenotypes; biomarkers; and connective networks both structurally and functionally (in terms of intrinsic connectivity networks, ICNs, including the DMN, SN, and CEN; that is, default mode, salience, and central executive networks, respectively)...
March 2, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28262136/support-for-the-association-between-rora-gene-polymorphisms-and-the-dsm-5-posttraumatic-stress-disorder-symptoms-in-male-earthquake-survivors-in-china
#4
Chengqi Cao, Li Wang, Xing Cao, Chongya Dong, Ping Liu, Shu Luo, Hong Cui, Jun Yang, Jianxin Zhang
BACKGROUND: This study examined the association between interaction of retinoid-related orphan receptor alpha (RORA) (rs8042149) genotype x trauma exposure and post-traumatic stress disorder (PTSD) symptoms. METHODS: A total of 1196 Chinese adults who suffered from a deadly 2008 Wenchuan earthquake participated in this study. PTSD symptoms were measured with the PTSD Checklist for DSM-5 (PCL-5). A custom-by-design 2×48-Plex SNPscan™Kit were used to genotype the RORA rs8042149 SNP...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28262088/genome-wide-association-study-of-post-traumatic-stress-disorder-in-two-high-risk-populations
#5
Whitney E Melroy-Greif, Kirk C Wilhelmsen, Rachel Yehuda, Cindy L Ehlers
Mexican Americans (MAs) and American Indians (AIs) constitute conspicuously understudied groups with respect to risk for post-traumatic stress disorder (PTSD), especially in light of findings showing racial/ethnic differences in trauma exposure and risk for PTSD. The purpose of this study was to examine genetic influences on PTSD in two minority cohorts. A genome-wide association study (GWAS) with sum PTSD symptoms for trauma-exposed subjects was run in each cohort. Six highly correlated variants in olfactory receptor family 11 subfamily L member 1 (OR11L1) were suggestively associated with PTSD in the MA cohort...
March 6, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28257413/uncovering-precision-phenotype-biomarker-associations-in-traumatic-brain-injury-using-topological-data-analysis
#6
Jessica L Nielson, Shelly R Cooper, John K Yue, Marco D Sorani, Tomoo Inoue, Esther L Yuh, Pratik Mukherjee, Tanya C Petrossian, Jesse Paquette, Pek Y Lum, Gunnar E Carlsson, Mary J Vassar, Hester F Lingsma, Wayne A Gordon, Alex B Valadka, David O Okonkwo, Geoffrey T Manley, Adam R Ferguson
BACKGROUND: Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical and molecular mechanisms. Complete integration of these diverse data for TBI diagnosis and patient stratification remains an unmet challenge. METHODS AND FINDINGS: The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot multicenter study enrolled 586 acute TBI patients and collected diverse common data elements (TBI-CDEs) across the study population, including imaging, genetics, and clinical outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28254464/adra2b-deletion-variant-influences-time-dependent-effects-of-pre-learning-stress-on-long-term-memory
#7
Phillip R Zoladz, Alison M Dailey, Hannah E Nagle, Miranda K Fiely, Brianne E Mosley, Callie M Brown, Tessa J Duffy, Amanda R Scharf, McKenna B Earley, Boyd R Rorabaugh
Extensive work over the past few decades has shown that certain genetic variations interact with life events to confer increased susceptibility for the development of psychological disorders. The deletion variant of the ADRA2B gene, which has been associated with enhanced emotional memory and heightened amygdala responses to emotional stimuli, might confer increased susceptibility for the development of post-traumatic stress disorder (PTSD) or related phenotypes by increasing the likelihood of traumatic memory formation...
February 22, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28242325/genetic-approaches-for-the-study-of-ptsd-advances-and-challenges
#8
REVIEW
Sunayana B Banerjee, Filomene G Morrison, Kerry J Ressler
Post-traumatic stress disorder (PTSD) is a highly debilitating stress and anxiety-related disorder that occurs in response to specific trauma or abuse. Genetic risk factors may account for up to 30-40% of the heritability of PTSD. Understanding the gene pathways that are associated with PTSD, and how those genes interact with the fear and stress circuitry to mediate risk and resilience for PTSD will enable the development of targeted therapies to prevent the occurrence of or decrease the severity of this complex multi-gene disorder...
February 24, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28215878/neuroactive-steroids-and-ptsd-treatment
#9
REVIEW
Ann M Rasmusson, Christine E Marx, Suzanne L Pineles, Andrea Locci, Erica R Scioli-Salter, Yael I Nillni, Jennifer J Liang, Graziano Pinna
This review highlights early efforts to translate pre-clinical and clinical findings regarding the role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD. Numerous studies have demonstrated PTSD-related alterations in resting levels or the reactivity of neuroactive steroids and their targets. These studies also have demonstrated substantial variability in the dysfunction of specific neuroactive steroid systems among PTSD subpopulations. These variabilities have been related to the developmental timing of trauma, severity and type of trauma, genetic background, sex, reproductive state, lifestyle influences such as substance use and exercise, and the presence of comorbid conditions such as depression and chronic pain...
February 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28205604/selectively-bred-rats-provide-a-unique-model-of-vulnerability-to-ptsd-like-behavior-and-respond-differentially-to-fgf2-augmentation-early-in-life
#10
Katherine E Prater, Elyse L Aurbach, Hanna K Larcinese, Taylor N Smith, Cortney A Turner, Peter Blandino, Stanley J Watson, Stephen Maren, Huda Akil
Individuals respond differently to traumatic experiences including their propensity to develop post-traumatic stress disorder (PTSD). Understanding individual differences in PTSD vulnerability will allow the development of improved prevention and treatment options. Here, we characterized fear conditioning and extinction in rats selectively bred for differences in their locomotor response to a novel environment. Selectively bred high responder (bHR) and low responder (bLR) male rats are known to differ in their emotional reactivity on a range of measures of spontaneous anxiety- and depressive-like behaviors...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28160694/genetic-and-serum-biomarker-evidence-for-a-relationship-between-tnf%C3%AE-and-ptsd-in-vietnam-war-combat-veterans
#11
Dagmar Bruenig, Divya Mehta, Charles P Morris, Wendy Harvey, Bruce Lawford, Ross McD Young, Joanne Voisey
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with increased inflammation and comorbid medical conditions. However, study findings for individual inflammatory marker levels have been inconsistent. Some research suggests that resilience may play a role in decreased inflammation. A polymorphism in the promoter region of the tumor necrosis factor α gene (TNFα), TNFA -308 (rs1800629) is associated with psychiatric illness but its role in PTSD is yet to be elucidated. OBJECTIVE: This study investigates a key inflammatory marker, TNFα, for its role in PTSD severity...
January 24, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28143760/pretreatment-biomarkers-predicting-ptsd-psychotherapy-outcomes-a-systematic-review
#12
REVIEW
Peter J Colvonen, Lisa H Glassman, Laura D Crocker, Melissa M Buttner, Henry Orff, Dawn M Schiehser, Sonya B Norman, Niloofar Afari
Although our understanding of the relationship between posttraumatic stress disorder (PTSD), brain structure and function, neural networks, stress-related systems, and genetics is growing, there is considerably less attention given to which biological markers predict evidence-based PTSD psychotherapy outcomes. Our systematic PRISMA-informed review of 20 studies examined biomarkers as predictors of evidence-based PTSD psychotherapy outcomes. Results provide preliminary evidence that specific structural and functional neural systems (involved in information processing), glucocorticoid sensitivity and metabolism (part of the hypothalamic-pituitary-adrenal axis and the response to stress), heart rate (involved with fear habituation), gene methylation, and certain genotypes (associated with serotonin and glucocorticoids) predicted positive response to PTSD treatment...
January 28, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28115477/a-deletion-variant-of-the-%C3%AE-2b-adrenoceptor-modulates-the-stress-induced-shift-from-cognitive-to-habit-memory
#13
Lisa Wirz, Jan Wacker, Andrea Felten, Martin Reuter, Lars Schwabe
Stress induces a shift from hippocampus-based 'cognitive' towards dorsal striatum-based 'habitual' learning and memory. This shift is thought to have important implications for stress-related psychopathologies, including posttraumatic stress disorder (PTSD). However, there is large individual variability in the stress-induced bias towards habit memory and the factors underlying this variability are completely unknown. Here we hypothesized that a functional deletion variant of the gene encoding the α2b-adrenoceptor (ADRA2B), which has been linked to emotional memory processes and increased PTSD risk, modulates the stress-induced shift from cognitive towards habit memory...
January 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28097489/enhanced-histone-acetylation-in-the-infralimbic-prefrontal-cortex-is-associated-with-fear-extinction
#14
Sarfraj Ahmad Siddiqui, Sanjay Singh, Vandana Ranjan, Rajesh Ugale, Sudipta Saha, Anand Prakash
The molecular processes that establish fear memory are complex and involve a combination of genetic and epigenetic influences. Dysregulation of these processes can manifest in humans as a range of fear-related anxiety disorders like post-traumatic stress disorders (PTSD). In the present study, immunohistochemistry for acetyl H3, H4, c-fos, CBP (CREB-binding protein) in the infralimbic prefrontal cortex (IL-PFC) and prelimbic prefrontal cortex (PL-PFC) of mPFC (medial prefrontal cortex) and basal amygdala (BA), lateral amygdala (LA), centrolateral amygdala (CeL), centromedial amygdala (CeM) of the amygdala was performed to link region-specific histone acetylation to fear and extinction learning...
January 17, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28067785/relationships-between-gat1-and-ptsd-depression-and-substance-use-disorder
#15
Kaitlin E Bountress, Wei Wei, Christina Sheerin, Dongjun Chung, Ananda B Amstadter, Howard Mandel, Zhewu Wang
Post-traumatic stress disorder (PTSD), Major Depressive Disorder (MDD), and Substance Use Disorder (SUD) have large public health impacts. Therefore, researchers have attempted to identify those at greatest risk for these phenotypes. PTSD, MDD, and SUD are in part genetically influenced. Additionally, genes in the glutamate and gamma-aminobutyric acid (GABA) system are implicated in the encoding of emotional and fear memories, and thus may impact these phenotypes. The current study examined the associations of single nucleotide polymorphisms in GAT1 individually, and at the gene level, using a principal components (PC) approach, with PTSD, PTSD comorbid with MDD, and PTSD comorbid with SUD in 486 combat-exposed veterans...
January 5, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28030471/stress-related-psychological-symptoms-contribute-to-axial-pain-persistence-after-motor-vehicle-collision-path-analysis-results-from-a-prospective-longitudinal-study
#16
Rose K Feinberg, JunMei Hu, Mark A Weaver, Roger B Fillingim, Robert A Swor, David A Peak, Jeffrey S Jones, Niels K Rathlev, David C Lee, Robert M Domeier, Phyllis L Hendry, Israel Liberzon, Samuel A McLean
Posttraumatic stress disorder (PTSD) symptoms and pain after traumatic events such as motor vehicle collision (MVC) have been proposed to be mutually promoting. We performed a prospective multicenter study that enrolled 948 individuals who presented to the emergency department within 24 hours of MVC and were discharged home after evaluation. Follow-up evaluations were completed 6 weeks, 6 months, and 1 year after MVC. Path analysis results supported the hypothesis that axial pain after MVC consistently promotes the maintenance of hyperarousal and intrusive symptoms, from the early weeks after injury through 1 year...
April 2017: Pain
https://www.readbyqxmd.com/read/28025095/a-cross-species-study-of-heterogeneity-in-fear-extinction-learning-in-relation-to-fkbp5-variation-and-expression-implications-for-the-acute-treatment-of-posttraumatic-stress-disorder
#17
Isaac R Galatzer-Levy, Raül Andero, Takehito Sawamura, Tanja Jovanovic, Santiago Papini, Kerry J Ressler, Seth Davin Norrholm
Deficits in fear extinction learning are hypothesized to underlie the development of posttraumatic stress disorder (PTSD). Such deficits may, in part, be due to genetic and epigenetic variation in the stress related gene FKBP5. Conversely, altering FKBP5 epigenetic responses during memory consolidation may rescue extinction deficits making it a target for acute intervention to prevent the development of PTSD. Study 1 (Humans) examines if FKBP5 single nucleotide polymorphisms (SNPs) and PTSD symptom domains (re-experiencing, avoidance/numbing, hyperarousal) are associated with abnormal fear extinction phenotypes identified using latent growth mixture modeling (LGMM)...
December 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27959335/functional-evaluation-of-a-ptsd-associated-genetic-variant-estradiol-regulation-and-adcyap1r1
#18
K B Mercer, B Dias, D Shafer, S A Maddox, J G Mulle, P Hu, J Walton, K J Ressler
Posttraumatic stress disorder (PTSD) affects 5-10% percent of the US adult population with a higher prevalence among women compared with men. Although it remains unclear how biological sex associates with susceptibility to PTSD, one mechanism may involve a role for estrogen in a gene by environment interaction. We previously demonstrated a sex-dependent association between the pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) and PTSD, where carriers of a C allele at single-nucleotide polymorphism (SNP) rs2267735 within the PAC1 receptor gene (ADCYAP1R1) have increased symptoms of PTSD...
December 13, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27933312/the-genetics-and-epigenetics-of-ptsd-overview-recent-advances-and-future-directions
#19
Christina M Sheerin, Mackenzie J Lind, Kaitlin Bountress, Nicole R Nugent, Ananda B Amstadter
This paper provides a brief summary and commentary on the growing literature and current developments related to the genetic underpinnings of posttraumatic stress disorder (PTSD). We first briefly provide an overview of the behavioral genetic literature on PTSD, followed by a short synopsis of the substantial candidate gene literature with a focus on genes that have been meta-analyzed. We then discuss the genome-wide association studies (GWAS) that have been conducted, followed by an introduction to other molecular platforms used in PTSD genomic studies, such as epigenetic and expression approaches...
April 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/27908524/genetic-correlation-between-alcohol-preference-and-conditioned-fear-exploring-a-functional-relationship
#20
Julia A Chester, Marcus M Weera
Post-traumatic stress disorder (PTSD) and alcohol-use disorders have a high rate of co-occurrence, possibly because they are regulated by common genes. In support of this idea, mice selectively bred for high (HAP) alcohol preference show greater fear potentiated startle (FPS), a model for fear-related disorders such as PTSD, compared to mice selectively bred for low (LAP) alcohol preference. This positive genetic correlation between alcohol preference and FPS behavior suggests that the two traits may be functionally related...
February 2017: Alcohol
keyword
keyword
49360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"