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https://www.readbyqxmd.com/read/29907653/re-thinking-re-synching-in-left-ventricular-assist-device-recipients
#1
EDITORIAL
Justin M Vader, Daniel H Cooper, Praveen Rao
No abstract text is available yet for this article.
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907652/cardiac-resynchronization-therapy-and-clinical-outcomes-in-continuous-flow-left-ventricular-assist-device-recipients
#2
Rakesh Gopinathannair, Henri Roukoz, Adarsh Bhan, Ashwin Ravichandran, Mustafa M Ahmed, Dmitry Familtsev, Geetha Bhat, Jennifer Cowger, Munazzah Abdullah, Chirag Sandesara, Rahul Dhawan, Emma J Birks, Jaimin R Trivedi, Mark S Slaughter
BACKGROUND: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients. METHODS AND RESULTS: Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907499/incidence-of-temporary-mechanical-circulatory-support-before-heart-transplantation-and-impact-on-post-transplant-outcomes
#3
David Ouyang, Gunsagar Gulati, Richard Ha, Dipanjan Banerjee
BACKGROUND: Proposed changes to the United Network for Organ Sharing heart transplant allocation protocol will prioritize patients receiving temporary mechanical circulatory support (tMCS), including extracorporeal membrane oxygenation (ECMO), percutaneous ventricular assist devices (PVADs), and intra-aortic balloon pumps (IABPs). We sought to evaluate contemporary trends in the incidence and outcomes of patients who required tMCS during the hospitalization before heart transplantation...
April 26, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29907280/ventricular-assist-devices-for-cardiogenic-shock-and-advanced-chronic-heart-failure
#4
EDITORIAL
Srinivas Murali
No abstract text is available yet for this article.
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907278/challenges-and-future-directions-in-left-ventricular-assist-device-therapy
#5
REVIEW
Manreet K Kanwar, Stephen Bailey, Srinivas Murali
The clinical use of left ventricular assist devices (LVADs) in the growing epidemic of heart failure has improved quality of life and long-term survival for this otherwise devastating disease. The current generation of commercially available devices offers a smaller profile that simplifies surgical implantation, a design that optimizes blood flow characteristics, with less adverse events and improved durability than their predecessors. Despite this, the risk for adverse events remains significant, as do burdens for patients and their caregivers...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907277/complications-of-durable-left-ventricular-assist-device-therapy
#6
REVIEW
Sitaramesh Emani
Heart failure patients on durable left ventricular assist device support experience improved survival, quality of life, and exercise capacity. The complication rate, however, remains unacceptably high, although it has declined with improvements in pump design, better patient selection, and greater understanding of the pump physiology and flow dynamics. Most complications are categorized as those related to the pump-patient interface or those related to patient physiology. It is hoped that further engineering progress, and better patient selection through risk stratification, will allow for left ventricular assist device to be totally biocompatible and perform effectively, without affecting biology and homeostasis of the different organ systems...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907276/device-management-and-flow-optimization-on-left-ventricular-assist-device-support
#7
REVIEW
Inna Tchoukina, Melissa C Smallfield, Keyur B Shah
The authors discuss principles of continuous flow left ventricular assist device (LVAD) operation, basic differences between the axial and centrifugal flow designs and hemodynamic performance, normal LVAD physiology, and device interaction with the heart. Systematic interpretation of LVAD parameters and recognition of abnormal patterns of flow and pulsatility on the device interrogation are necessary for clinical assessment of the patient. Optimization of pump flow using LVAD parameters and echocardiographic and hemodynamics guidance are reviewed...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907275/prevention-and-treatment-of-right-ventricular-failure-during-left-ventricular-assist-device-therapy
#8
REVIEW
Amresh Raina, Maria Patarroyo-Aponte
Left ventricular assist devices (LVAD) are increasingly used for the treatment of end-stage heart failure. Right ventricular (RV) failure after LVAD implantation is an increasingly common clinical problem, occurring in patients early after continuous flow LVAD implant. RV failure is associated with a substantial increase in post-LVAD morbidity and mortality. RV failure can be predicted using preoperative hemodynamic, clinical, and echocardiographic variables and a variety of risk prediction algorithms. However, RV failure may also develop due to unanticipated intraoperative or perioperative factors...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29906524/timing-of-gastrointestinal-bleeding-after-implantation-of-left-ventricular-assist-devices-associates-with-anatomic-location-presentation-and-management
#9
James H Tabibian, Daniel P Rhoades, Kimberly A Forde, Rhondalyn C McLean, Vinay Chandrasekhara
BACKGROUND & AIMS: Continuous-flow left ventricular assist devices (LVADs) for advanced heart failure have been associated with gastrointestinal bleeding (GIB). We examined the association between time of GIB after LVAD implantation and bleeding location (determined by endoscopy), etiology, and patient outcomes. METHODS: We performed a retrospective study of consecutive patients who underwent implantation of continuous-flow LVADs from 2008 through 2015. We analyzed data on anatomic location of GIB, etiology, length of hospital stay, transfusion requirement, time to endoscopy, and rate of readmission within 30 days...
June 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29905971/impact-of-insurance-type-on-eligibility-for-advanced-heart-failure-therapies-and-survival
#10
Sarah Streeter Hutcheson, Victoria Phillips, Rachel Patzer, Andrew Smith, J David Vega, Alanna A Morris
BACKGROUND: Medicaid insurance in Georgia provides limited reimbursement for heart transplant (HT) and left ventricular assist devices (LVAD). We examined whether insurance type affects eligibility for and survival after receipt of HT or LVAD. METHODS AND RESULTS: We retrospectively identified patients evaluated for HT/LVAD from 2012 to 2016. We used multivariable logistic and Cox proportional hazards regression to examine the association of insurance type on treatment eligibility and one year survival...
June 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29905854/comparison-of-temporary-ventricular-assist-devices-and-extracorporeal-life-support-in-post-cardiotomy-cardiogenic-shock
#11
Prashant N Mohite, Anton Sabashnikov, Achim Koch, Raj Binu, Ashok Padukone, Sundip Kaul, Olaf Maunz, Diana García-Sáez, Bartlomiej Zych, Mubassher Husain, Fabio De Robertis, Aron-Frederik Popov, André R Simon
OBJECTIVES: Post-cardiotomy cardiogenic shock (PCCS) results in substantial morbidity and mortality, whereas refractory cases require mechanical circulatory support (MCS). The aim of the study was to compare extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (VADs) utilized in the management of PCCS. METHODS: In total, 56 consecutive patients who developed PCCS from 2005 to 2014 required MCS as a bridge to decision-24 were supported with a VAD and 32 with an ECMO...
June 13, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29905775/long-term-heart-transplant-outcomes-after-lowering-fixed-pulmonary-hypertension-using-left-ventricular-assist-devices
#12
Roxana Moayedifar, Andreas Zuckermann, Arezu Aliabadi-Zuckermann, Julia Riebandt, Philipp Angleitner, Kamen Dimitrov, Thomas Schloeglhofer, Angela Rajek, Guenther Laufer, Daniel Zimpfer
OBJECTIVES: Fixed pulmonary hypertension (fPH) is a contraindication for heart transplantation (HTX). Left ventricular assist device (LVAD) implantation as a bridge to candidacy can reverse fPH in patients with terminal heart failure by chronic left ventricular unloading. We report our institutional experience with terminal heart failure patients and fPH that were successfully bridged to candidacy and underwent subsequent HTX. METHODS: We retrospectively reviewed the data of 79 patients with terminal heart failure and fPH who were successfully bridged to candidacy for HTX with 6 different LVAD devices at our centre from October 1998 to September 2016 (Novacor n = 4, MicroMed DeBakey n = 29, DuraHeart n = 2, HeartMate II n = 14, HVAD n = 29 and MVAD n = 1)...
June 13, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29903893/living-without-a-pulse-the-vascular-implications-of-continuous-flow-left-ventricular-assist-devices
#13
Suneet N Purohit, William K Cornwell, Jay D Pal, JoAnn Lindenfeld, Amrut V Ambardekar
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29903518/3d-echocardiography-derived-right-ventricular-function-is-associated-with-right-ventricular-failure-and-mid-term-survival-after-left-ventricular-assist-device-implantation
#14
Harry Magunia, Clemens Dietrich, Harald F Langer, David Schibilsky, Christian Schlensak, Peter Rosenberger, Martina Nowak-Machen
BACKGROUND: Right heart failure remains a major cause of morbidity and mortality after left ventricular assist device (LVAD) implantation. Multiple 2D echocardiography derived parameters are associated with right ventricular failure (RV failure), but none of them has been proven to be a reliable predictor to date. We hypothesized that novel 3D-echocardiography (3DE) based parameters are associated with RV failure and predict long term outcome in patients undergoing LVAD implantation. METHODS: This single-center study retrospectively enrolled 26 patients undergoing continuous-flow LVAD implantation...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29901474/solving-the-puzzle-of-the-hematologic-left-ventricular-assist-device-interface-one-piece-at-a-time
#15
Jennifer A Cowger, Keyur B Shah
No abstract text is available yet for this article.
June 11, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29900585/neurohormone-levels-remain-elevated-in-continuous-flow-left-ventricular-assist-device-recipients
#16
Liza Grosman-Rimon, Michael A McDonald, Danit Freedman, Paul Yip, David Z Cherney, Vivek Rao
INTRODUCTION: The levels of neurohormones were assessed in continuous-flow left ventricular assist device (CF-LVAD) recipients and compared to patients with heart failure (HF) and to healthy controls (HCs), and CF-LVAD recipients with closed or open aortic valves (AVs). METHODS: Aldosterone, norepinephrine, and renin levels were assessed in a total of 46 participants, including CF-LVAD recipients (n = 18), HF patients (n = 14), and HC individuals (n = 14)...
June 14, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29900083/microbubbles-in-the-aorta-and-left-ventricle-of-a-patient-with-a-left-ventricular-assist-device-a-unique-presentation-of-pump-thrombosis-leading-to-urgent-surgery
#17
Kantha R Kolla, Simon Maltais, Naveen L Pereira, Hari P Chaliki
Microbubble formation occurs due to the cavitation phenomenon. We report a rare echocardiographic finding of microbubbles in a patient's aorta and left ventricle due to pump thrombosis in the left ventricle assist device, requiring pump exchange surgery.
April 11, 2018: Curēus
https://www.readbyqxmd.com/read/29898422/cerebral-small-vessel-disease-and-the-risk-of-alzheimer-s-disease-a-systematic-review
#18
REVIEW
Yue Liu, Nady Braidy, Anne Poljak, Daniel Ky Chan, Perminder Sachdev
BACKGROUND: Cerebral small vessel disease (CSVD) comprises a variety of disorders affecting small arteries and microvessels of the brain, manifesting as white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and deep brain infarcts. In addition to its contribution to vascular dementia (VaD), it has also been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). METHOD: A systematic review of the literature available on Medline, Embase and Pubmed was undertaken, whereby CSVD was divided into WMHs, CMBs and deep brain infarcts...
June 10, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29897441/left-ventricular-assist-device-implantation-with-and-without-concomitant-tricuspid-valve-surgery-a-systematic-review-and-meta-analysis
#19
Kevin M Veen, Rahatullah Muslem, Osama I Soliman, Kadir Caliskan, Marit E A Kolff, Dagmar Dousma, Olivier C Manintveld, Ozcan Birim, Ad J J C Bogers, Johanna J M Takkenberg
OBJECTIVES: Moderate-to-severe tricuspid regurgitation is common in end-stage heart disease and is associated with an impaired survival after left ventricular assist device (LVAD) surgery. Controversy remains whether concomitant tricuspid valve surgery (TVS) during LVAD implantation is beneficial. We aimed to provide a contemporary overview of outcomes in patients who underwent LVAD surgery with or without concomitant TVS. METHODS: A systematic literature search was performed for articles published between January 2005 and March 2017...
April 20, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29896993/prolonged-veno-arterial-extracorporeal-life-support-for-cardiac-failure
#20
Sabina Pw Guenther, Yasuhiro Shudo, William Hiesinger, Dipanjan Banerjee
OBJECTIVES: In intractable cardiogenic shock, extracorporeal life support frequently is the last treatment option. Outcomes of prolonged veno-arterial extracorporeal life support for cardiac failure are poorly defined. METHODS: We retrospectively analyzed 10 patients (4 females, age = 36 ± 16 years) who underwent prolonged extracorporeal life support (≥7 days) from December 2015 to March 2017 for cardiogenic shock. The primary endpoint was survival to hospital discharge...
June 1, 2018: International Journal of Artificial Organs
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