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https://www.readbyqxmd.com/read/29236180/diagnosis-medical-treatment-and-stepwise-mechanical-circulatory-support-for-fulminat-myocarditis
#1
Shunsuke Saito, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Keitaro Domae, Yasumasa Tsukamoto, Yasushi Sakata, Yoshiki Sawa
Fulminant myocarditis is one of the most challenging diseases. We sought to examine the outcomes of our multidisciplinary treatment strategy for fulminant myocarditis. A retrospective review of consecutive 30 patients with fulminant myocarditis was conducted. Of the 30 patients, 25 required mechanical circulatory support (MCS). Percutaneous extracorporeal membrane oxygenation (ECMO) was the first-line therapy to rescue the patients and inserted in 23 of them. The other 2 were implanted with temporary ventricular assist device (t-VAD) with extracorporeal centrifugal pump(s)...
December 13, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29235399/reviewing-the-use-of-ventricular-assist-devices-in-the-elderly-where-do-we-stand-today
#2
Nandini Nair, Enrique Gongora
Implantation of left ventricular assist devices (LVADS) in older patients appears to be an attractive option in the wake of donor shortage and increasing incidence and prevalence of end stage heart failure. Since the inception of the artificial heart program half a century ago tremendous progress in research and development has led to utilization of more sophisticated devices. VADs have therefore emerged as a successful therapy for extending life with meaningful quality. Areas covered: This review will address the use of LVADS as a bridge to transplantation, destination therapy and comparison of LVAD therapy with alternate list heart transplantation in the elderly population...
December 13, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29235130/melt-electrospun-bilayered-scaffolds-for-tissue-integration-of-a-suture-less-inflow-cannula-for-rotary-blood-pumps
#3
Sam Liao, Christina Theodoropoulos, Keith A Blackwood, Maria A Woodruff, Shaun D Gregory
Implantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture-less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis of the myocardium. To circumvent this issue, a bilayered scaffold has been developed to promote tissue growth at the interface between cannula and myocardium. The bilayered scaffold consists of a silicone base layer, which mimics the seal, and a melt electrospun polycaprolactone scaffold to serve as a tissue integration layer...
December 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29233971/implication-of-4e-bp1-protein-dephosphorylation-and-accumulation-in-pancreatic-cancer-cell-death-induced-by-combined-gemcitabine-and-trail
#4
Androulla Elia, Ricky Henry-Grant, Charlotte Adiseshiah, Catherine Marboeuf, Rebecca J Buckley, Michael J Clemens, Satvinder Mudan, Stéphane Pyronnet
Pancreatic cancer cells show varying sensitivity to the anticancer effects of gemcitabine. However, as a chemotherapeutic agent, gemcitabine can cause intolerably high levels of toxicity and patients often develop resistance to the beneficial effects of this drug. Combination studies show that use of gemcitabine with the pro-apoptotic cytokine TRAIL can enhance the inhibition of survival and induction of apoptosis of pancreatic cancer cells. Additionally, following combination treatment there is a dramatic increase in the level of the hypophosphorylated form of the tumour suppressor protein 4E-BP1...
December 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29233363/anticoagulant-free-off-pump-left-ventricular-assist-device-implant
#5
Jason Ali, Sendhil Balasubramanian, Marius Berman, Yasir Abu Omar, Steven Tsui
Implantable left ventricular assist device (LVAD) therapy is an established treatment for advanced heart failure. LVADs are usually implanted using intra-operative anticoagulation with or without cardiopulmonary bypass. We describe an anticoagulant-free off-pump LVAD implant technique to circumvent potential complications associated with conventional approaches. This technique is safe and is probably the least invasive surgical approach for LVAD implantation.
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29232736/-left-ventricular-assist-device-therapy-ways-to-improve-the-ambulatory-care
#6
Caspar Burkhard-Meier, Michiel Morshuis
The use of left-ventricular assist device therapy (LVAD) in terminal heart failure patients is increasing. Many patients are receiving LVAD-therapy as final solution (destination therapy). After discharge from the implanting heart center patient-centered care has to be implemented on an outpatient basis. A responsible ambulatory treatment of this severe heart failure population requires knowledge about LVAD specific problems (general medical care, long term complications, device management). The referring cardiologist as well as the private practitioner should be more involved in the care of patients with LVAD...
December 12, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29232297/long-term-success-with-driveline-exit-site-relocation-for-deep-driveline-infection-in-left-ventricular-assist-device-patients
#7
Leora B Balsam, Adam Jacoby, Eddie Louie, Jamie P Levine
OBJECTIVE: Driveline infection is a common complication of durable left ventricular assist device support. The majority involve the driveline exit site and can be treated with antibiotics and local wound care. Less frequently, these infections extend into deeper tissues and surgical debridement is necessary. Few studies have described the surgical strategy for treatment of deep driveline infection or have reported long-term outcomes. With a growing population of patients being implanted as destination therapy, there is an obvious need to evaluate and optimize treatment for complex driveline infections...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232275/complex-decision-making-in-heart-failure-a-systematic-review-and-thematic-analysis
#8
Aimee V Hamel, Joseph E Gaugler, Carolyn M Porta, Niloufar Niakosari Hadidi
BACKGROUND: Heart failure follows a highly variable and difficult course. Patients face complex decisions, including treatment with implantable cardiac defibrillators, mechanical circulatory support, and heart transplantation. The course of decision-making across multiple treatments is unclear yet integral to providing informed and shared decision-making. Recognizing commonalities across treatment decisions could help nurses and physicians to identify opportunities to introduce discussions and support shared decision-making...
December 11, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29230826/evolution-of-biventricular-loading-condition-in-pediatric-lvad-patient-a-prospective-and-observational-study
#9
Arianna Di Molfetta, Roberta Iacobelli, Sergio Filippelli, Giorgia Grutter, Gianluigi Perri, Francesca Iodice, Luciano Pasquini, Paolo Guccione, Antonio Amodeo
The aim of this study was to describe the echocardiographic trend of left ventricular (LV) and right ventricular (RV) function after implantation of a pulsatile flow left ventricular assist device (LVAD) in children. From 2013 to 2016, we prospectively evaluated 13 consecutive pediatric Berlin Heart EXCOR LVAD patients. Clinical and echocardiographic data were collected at baseline, within 24 h after implantation and monthly until LVAD explant. Median age and weight at the implantation was 8 (4-23) months and 5 (4...
December 12, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29230110/letter-to-the-editor-management-of-aortic-root-thrombosis-after-implantation-of-a-continuous-flow-left-ventricular-assist-device-a-real-conundrum
#10
John Gulotta, Daniel P Morin, Selim R Krim
No abstract text is available yet for this article.
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229420/ros-mediated-oligomerization-of-vdac2-is-associated-with-quinocetone-induced-apoptotic-cell-death
#11
Xiayun Yang, Shusheng Tang, Daowen Li, Bin Li, Xilong Xiao
Quinocetone (QCT) has been approved and widely used as an animal feed additive in China since 2003. However, investigations indicate that QCT shows potential toxicity both in vitro and in vivo. Although voltage dependent anion channel 1 (VDAC1) involved in regulating QCT-induced apoptotic cell death has been established, the role of voltage dependent anion channel 2 (VDAC2) in QCT-induced toxicity remains unclear. In this study, we showed that QCT-induced cell death was coupled to VDAC2 oligomerization. Moreover, VDAC inhibitor 4, 4'-diisothiocyano stilbene-2, 2'-disulfonic acid (DIDS) alleviated QCT-induced cell death and VDAC2 oligomerization...
December 8, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29229257/factors-related-to-the-severity-of-early-postoperative-infection-after-heart-transplantation-in-patients-surviving-prolonged-mechanical-support-periods-experience-at-a-single-university
#12
Ryuichiro Abe, Sho C Shibata, Shunsuke Saito, Yasumasa Tsukamoto, Koichi Toda, Akinori Uchiyama, Yasushi Sakata, Yoshiki Sawa, Kazunori Tomono, Yuji Fujino
OBJECTIVE: The authors examined the effect of prolonged support with continuous-flow ventricular assist devices (CF-VADs) and other related factors on the severity of infections within 30 days of heart transplantation (HTx). DESIGN: A retrospective analysis of consecutive HTx procedures. SETTING: University hospital, between 2010 and 2016. PARTICIPANTS: A cohort of 53 heart transplantation recipients (median age, 38...
July 8, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29226531/pre-implant-left-ventricular-apex-position-predicts-risk-of-heartmate-ii-pump-thrombosis
#13
Leora T Yarboro, James Hunter Mehaffey, Robert B Hawkins, Irving L Kron, Gorav Ailawadi, John A Kern, Ravi K Ghanta
BACKGROUND: Thrombosis within a left ventricular assist device (LVAD) is a devastating complication that often necessitates device exchange. Few studies have evaluated the relationship between patient anatomy and pump thrombosis. We hypothesize that lateral displacement of the left ventricular (LV) apex increases risk for pump thrombosis. METHODS: All patients who underwent primary implantation of a HeartMate II (HM2) device (Thoratec, Pleasanton, CA) at a single center (2009-2015) were evaluated...
December 10, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29225136/in-vitro-apoptotic-mechanism-of-a-novel-synthetic-quinazolinyl-derivative-induces-caspase-dependent-intrinsic-pathway-on-thp-1-leukemia-cell-line
#14
V Sridhar, S K Arepalli, L R Velatooru, J Venkateswara Rao, P Kavin Kennedy, B Narsaiah
Several quinazoline derivatives have been found to possess a broad spectrum of biological activities. Previously our research group has synthesized and studied the anti-proliferative effects of N-Decyl-N-(2-Methyl-4-Quinazolinyl) Amine (DMQA). The current study evaluated the cytotoxic and apoptotic properties of DMQA in THP-1 cells. The cytotoxic potential of DMQA was assessed using MTT assay on a panel of cancer cell lines which include HeLa, Mia PaCa-2, A 375, B16-F10, A 549,A 431, U937, THP-1, HL-60 and peripheral blood mononuclear cells (PBMC's)...
December 7, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29225132/ginsenoside-rh4-induces-apoptosis-and-autophagic-cell-death-through-activation-of-the-ros-jnk-p53-pathway-in-colorectal-cancer-cells
#15
Qian Wu, Jianjun Deng, Daidi Fan, Zhiguang Duan, Chenhui Zhu, Rongzhan Fu, Shanshan Wang
The use of ginsenosides in cancer therapy has been intensively investigated. The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics. Here, we investigated the antiproliferative activity and mechanisms of Rh4 in colorectal cancer, both in vivo and in vitro. A colorectal cancer xenograft model showed that Rh4 significantly inhibited tumor growth with few side effects. CCK-8 assays, flow cytometric analysis, Western blotting and immunohistochemistry revealed that Rh4 effectively suppressed colorectal cancer cell proliferation via inducing G0/G1 phase arrest, caspase-dependent apoptosis and autophagic cell death but was not significantly cytotoxic to normal colon epithelial cells...
December 7, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29223845/seeing-is-believing-a-call-for-routine-early-postoperative-hemodynamic-transesophageal-echocardiography-monitoring-after-left-ventricular-assist-device-implantation
#16
EDITORIAL
Juan N Pulido
No abstract text is available yet for this article.
November 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29223571/noval-nitroaromatic-compound-activates-autophagy-and-apoptosis-pathways-in-hl60%C3%A2-cells
#17
Gabriele Mendes M C Perdigão, Marcela Silva Lopes, Lucas Bonfim Marques, Pedro Henrique Dias Moura Prazeres, Kamila de Sousa Gomes, Renata Barbosa de Oliveira, Mauro Cunha Xavier Pinto, Elaine Maria de Souza-Fagundes
N-(2-butanoyloxyethyl)-4-(chloromethyl)-3-nitrobenzamide (NBCN) is a nitroaromatic bioreductible compound with cytotoxic effects in cancer cells lines. The aim of this work was investigated the molecular mechanisms involved in cell death promoted by NBCN on HL60 cells line. We observed that NBCN treatment increased intracellular ROS, reduced mitochondria membrane potential (ΔΨm). The treatment also induced morphological changes, phosphatidylserine exposure, cell cycle arrest in G2/M-phase, DNA condensation and fragmentation in HL60 cells, but did not showed cytotoxic effects on normal human peripheral blood mononuclear cells (PBMC)...
December 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29223421/a-prospective-multi-institutional-cohort-study-of-mediastinal-infections-after-cardiac-operations
#18
Louis P Perrault, Katherine A Kirkwood, Helena L Chang, John C Mullen, Brian C Gulack, Michael Argenziano, Annetine C Gelijns, Ravi K Ghanta, Bryan A Whitson, Deborah L Williams, Nancy M Sledz-Joyce, Brian Lima, Giampaolo Greco, Nishit Fumakia, Eric A Rose, John D Puskas, Eugene H Blackstone, Richard D Weisel, Michael E Bowdish
BACKGROUND: Mediastinal infections are a potentially devastating complication of cardiac operations. This study analyzed the frequency, risk factors, and perioperative outcomes of mediastinal infections after cardiac operations. METHODS: In 2010, 5,158 patients enrolled in a prospective study evaluating infections after cardiac operations and their effect on readmissions and mortality for up to 65 days after the procedure. Clinical and demographic characteristics, operative variables, management practices, and outcomes were compared for patients with and without mediastinal infections, defined as deep sternal wound infection, myocarditis, pericarditis, or mediastinitis...
December 6, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29223417/left-ventricular-assist-device-impact-on-aortic-valve-mechanics-proteomics-and-ultrastructure
#19
Elizabeth H Stephens, Jiho Han, Emma A Trawick, Elena S Di Martino, Hemanth Akkiraju, Lewis M Brown, Jennifer P Connell, K Jane Grande-Allen, Gordana Vunjak-Novakovic, Hiroo Takayama
BACKGROUND: Aortic regurgitation is a prevalent, detrimental complication of left ventricular assist devices (LVADs). The altered hemodynamics of LVADs results in aortic valves (AVs) having distinct mechanical stimulation. Our hypothesis was that the altered AV hemodynamics modulates the valve cells and matrix, resulting in changes in valvular mechanical properties that then can lead to regurgitation. METHODS: AVs were collected from 16 LVAD and 6 non-LVAD patients at time of heart transplant...
December 6, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29223289/frequency-and-consequences-of-right-sided-heart-failure-after-continuous-flow-left-ventricular-assist-device-implantation
#20
Chitaru Kurihara, Andre C Critsinelis, Masashi Kawabori, Tadahisa Sugiura, Gabriel Loor, Andrew B Civitello, Jeffrey A Morgan
Postoperative right-sided heart failure (RHF) is a common complication after continuous-flow left ventricular assist device implantation. Studies have examined RHF in the perioperative period, but few have assessed late-onset RHF. We analyzed the incidence of early and late RHF in patients with HeartMate II and HeartWare left ventricular assist devices and associated morbidity, mortality, and independent predictors of RHF. We retrospectively analyzed records of 526 patients with chronic heart failure who underwent continuous-flow left ventricular assist device implantation; 147 (27...
October 31, 2017: American Journal of Cardiology
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