Yekaterina Shulgina, Marena I Trinidad, Conner J Langeberg, Hunter Nisonoff, Seyone Chithrananda, Petr Skopintsev, Amos J Nissley, Jaymin Patel, Ron S Boger, Honglue Shi, Peter H Yoon, Erin E Doherty, Tara Pande, Aditya M Iyer, Jennifer A Doudna, Jamie H D Cate
Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. While advances in deep learning enable the prediction of accurate protein structural models, RNA structure prediction is not possible at present due to a lack of abundant high-quality reference data. Furthermore, available sequence data are generally not associated with organismal phenotypes that could inform RNA function. We created GARNET (Gtdb Acquired RNa with Environmental Temperatures), a new database for RNA structural and functional analysis anchored to the Genome Taxonomy Database (GTDB)...
April 6, 2024: bioRxiv