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https://www.readbyqxmd.com/read/29451409/temporal-trends-in-incidence-and-outcome-of-hydatidiform-mole-a-retrospective-cohort-study
#1
Urika Joneborg, Yasin Folkvaljon, Nikos Papadogiannakis, Mats Lambe, Lena Marions
BACKGROUND: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County. MATERIAL AND METHODS: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. The incidence of HM was assessed both in relation to number of births and viable conceptions (births and pregnancy terminations)...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29447367/endometrial-natural-killer-nk-cells-reveal-a-tissue-specific-receptor-repertoire
#2
D Feyaerts, T Kuret, B van Cranenbroek, S van der Zeeuw-Hingrez, O W H van der Heijden, A van der Meer, I Joosten, R G van der Molen
STUDY QUESTION: Is the natural killer (NK) cell receptor repertoire of endometrial NK (eNK) cells tissue-specific? SUMMARY ANSWER: The NK cell receptor (NKR) expression profile in pre-pregnancy endometrium appears to have a unique tissue-specific phenotype, different from that found in NK cells in peripheral blood, suggesting that these cells are finely tuned towards the reception of an allogeneic fetus. WHAT IS KNOWN ALREADY: NK cells are important for successful pregnancy...
February 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29447340/dysfunction-of-ddit4-in-the-decidua-is-relevant-to-the-pathogenesis-of-preeclampsia
#3
Jieqiong Yang, Yachao Zhang, Jing Tong, Hong Lv, Cong Zhang, Zi-Jiang Chen
Preeclampsia (PE) is a pregnancy-related disorder that occurs after 20 weeks of gestation and affects 3-5% of all human pregnancies worldwide. However, the pathogenesis of PE still remains poorly understood. A deficiency in decidualization is considered a contributing factor to the development of PE. The DNA damage inducible transcript 4 (DDIT4) gene encodes a protein whose main function is inhibiting mammalian target of rapamycin (mTOR) under stress, and several studies have demonstrated that its expression promotes tumor cell apoptosis...
February 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29446169/oxygen-concentration-modulates-cellular-senescence-and-autophagy-in-human-trophoblast-cells
#4
Kotomi Seno, Nao Tanikawa, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
PROBLEM: We investigated the effect of oxygen concentrations on cellular senescence and autophagy and examined the role of autophagy in human trophoblast cells. METHOD OF STUDY: Human first-trimester trophoblast cells (Sw.71) were incubated under 21%, 5%, or 1% O 2 concentrations for 24 hours. We examined the extent of senescence caused using senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated secretory phenotype (SASP) as markers. Moreover, we examined the role of autophagy in causing cellular senescence using an autophagy inhibitor (3-methyladenine, 3MA)...
February 15, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29445070/development-to-term-of-sheep-embryos-reconstructed-after-inner-cell-mass-trophoblast-exchange
#5
Pasqualino Loi, Cesare Galli, Giovanna Lazzari, Kazutsugu Matsukawa, Josef Fulka Jr, Frank Goeritz, Thomas B Hildebrandt
Here we report in vitro and term development of sheep embryos after the inner cell mass (ICM) from one set of sheep blastocysts were injected into the trophoblast vesicles of another set. We also observed successful in vitro development of chimeric blastocysts made from sheep trophoblast vesicles injected with bovine ICM. First, we dissected ICMs from 35 sheep blastocysts using a stainless steel microblade and injected them into 29 re-expanded sheep trophoblastic vesicles. Of the 25 successfully micromanipulated trophoblastic vesicles, 15 (51...
February 15, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29444856/placental-physiology-monitored-by-hyperpolarized-dynamic-13-c-magnetic-resonance
#6
Stefan Markovic, Anne Fages, Tangi Roussel, Ron Hadas, Alexander Brandis, Michal Neeman, Lucio Frydman
Placental functions, including transport and metabolism, play essential roles in pregnancy. This study assesses such processes in vivo , from a hyperpolarized MRI perspective. Hyperpolarized urea, bicarbonate, and pyruvate were administered to near-term pregnant rats, and all metabolites displayed distinctive behaviors. Little evidence of placental barrier crossing was observed for bicarbonate, at least within the timescales allowed by 13 C relaxation. By contrast, urea was observed to cross the placental barrier, with signatures visible from certain fetal organs including the liver...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29443880/magnetic-nanoparticles-interact-and-pass-an-in-vitro-co-culture-blood-placenta-barrier-model
#7
Elena K Müller, Christine Gräfe, Frank Wiekhorst, Christian Bergemann, Andreas Weidner, Silvio Dutz, Joachim H Clement
Magnetic nanoparticles are interesting tools for biomedicine. Before application, critical prerequisites have to be fulfilled. An important issue is the contact and interaction with biological barriers such as the blood-placenta barrier. In order to study these processes in detail, suitable in vitro models are needed. For that purpose a blood-placenta barrier model based on the trophoblast-like cell line BeWo and primary placenta-derived pericytes was established. This model was characterized by molecular permeability, transepithelial electrical resistance and cell-cell-contact markers...
February 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29439620/acute-drug-effects-on-the-human-placental-tissue-the-development-of-a-placental-murine-xenograft-model
#8
Magali Verheecke, Els Hermans, Sandra Tuyaerts, Erika Souche, Rita Van Bree, Godelieve Verbist, Tina Everaert, Jeroen Van Houdt, Kristel Van Calsteren, Frederic Amant
OBJECTIVE: A pilot study was conducted to establish a human placental xenograft, which could serve as a model to evaluate the effect of toxic exposures during pregnancy. STUDY DESIGN: The protocol consisted of engraftment of third-trimester human placental tissue in immunocompromised mice, after induction of a pseudo-pregnancy state by ovariectomy and progesterone supplementation. To validate the model, the placental tissue before and after engraftment was examined by immunohistochemistry, fluorescence-activated cell sorting (FACS), single-nucleotide polymorphism (SNP) genotyping, and whole transcriptome sequencing (WTSS)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439617/low-density-lipoprotein-receptor-related-protein-6-is-essential-for-trophoblast-survival-and-invasion
#9
Lei Li, Jipeng Wan, Jing Xue, Hongyan Li, Shan Wang, Qian Zhou, Yu Zhou, Xietong Wang
Remodeling of maternal spiral artery after the implantation of embryo relies on tightly regulated trophoblast functions and is pivotal to ensure the success of pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis and several vascular diseases, but its function in trophoblast regulation is still not fully understood. We aimed to investigate the involvement of LRP6 in trophoblast functions during maternal spiral artery remodeling. HTR-8/SVneo cells, a trophoblast cell line, were employed to examine the impact of LRP6 knockdown on proliferation, apoptosis, and migration, as well as invasion and tube formation...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439094/uterine-and-placental-distribution-of-selected-extracellular-matrix-ecm-components-in-the-dog
#10
Felix R Graubner, Alois Boos, Selim Aslan, Ibrahim Kücükaslan, Mariusz P Kowalewski
For many years, modifications of the uterine extracellular matrix (ECM) during gestation have not been considered as critical for successful canine (Canis lupus familiaris) pregnancy. However previous reports indicated an effect of free-floating blastocysts on the composition of the uterine ECM. Here, the expression of selected genes involved in structural functions, cell-to-cell communication and inhibition of matrix metalloproteinases were targeted utilizing qPCR and immunohistochemistry. We found that canine free-floating embryos affect gene expression of FN1, ECM1 and TIMP4...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29438487/successful-derivation-of-human-trophoblast-stem-cells
#11
Yue Wang, Hongmei Wang
No abstract text is available yet for this article.
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29438480/human-trophoblast-epithelial-mesenchymal-transition-in-abnormally-invasive-placenta
#12
Sonia DaSilva-Arnold, Stacy Zamudio, Abdulla Al-Khan, Jesus Alvarez-Perez, Ciaran Mannion, Christopher Koenig, Davlyn Luke, Anisha Perez, Margaret Petroff, Manuel Alvarez, Nicholas P Illsley
Differentiation of first trimester human placental cytotrophoblast from an anchorage-dependent epithelial phenotype into the mesenchymal-like invasive extravillous trophoblast is crucial in the development of the maternal-fetal interface. We showed previously that differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition (EMT). Here we compare the epithelial-mesenchymal characteristics of cytotrophoblast (CTB) and extravillous trophoblast (EVT) derived from normal third trimester placenta or placenta previa versus abnormally invasive placenta (AIP)...
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29437897/tlr9-toll-like-receptor-9-agonist-suppresses-angiogenesis-by-differentially-regulating-vegfa-vascular-endothelial-growth-factor-a-and-sflt1-soluble-vascular-endothelial-growth-factor-receptor-1-in-preeclampsia
#13
Biwei He, Xingyu Yang, Yamei Li, Ding Huang, Xin Xu, Wenjun Yang, Yan Dai, Huijuan Zhang, Zhengjun Chen, Weiwei Cheng
Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women...
February 5, 2018: Hypertension
https://www.readbyqxmd.com/read/29437882/decidual-regulation-of-trophoblast-is-altered-in-pregnancies-at-risk-of-pre-eclampsia
#14
Laura B James-Allan, Guy StJ Whitley, Karin Leslie, Alison E Wallace, Judith E Cartwright
Successful implantation and placentation are dependent on the interaction between decidual stromal cells (DSC) and extravillous trophoblast (EVT) cells. The extent of trophoblast invasion relies on communication between the placenta and maternal decidua. The cyclical process of decidualisation induces a transformation of endometrial fibroblasts to secretory DSC; these secreted products have many functions including the control of trophoblast invasion. Inadequate trophoblast invasion and remodelling of the uterine vessels (the spiral arteries) are associated with pregnancy disorders such as pre-eclampsia...
February 7, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29436666/daidzein-induces-choriocarcinoma-cell-apoptosis-in-a-dose-dependent-manner-via-the-mitochondrial-apoptotic-pathway
#15
Wei Zheng, Teng Liu, Rong Sun, Lei Yang, Ruifang An, Yan Xue
Choriocarcinoma is a malignant gestational trophoblastic disease and relapse or drug resistance occurs in ~25% of gestational trophoblastic tumors. Cell apoptosis serves a role in the progression from hydatidiform mole to persistent gestational trophoblastic disease. It has been demonstrated that daidzein [7‑hydroxy‑3‑(4‑hydroxyphenyl)‑4H‑chromen‑4‑one] may induce apoptosis in a number of cancer types via the mitochondrial apoptotic pathway by altering the B‑cell lymphoma (Bcl)‑2/Bcl‑2 associated X, apoptosis regulator (Bax) ratio, and activating the caspase cascade...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436119/laparoscopic-diagnosis-and-treatment-of-an-isolated-epithelioid-trophoblastic-tumor-in-recto-uterine-pouch
#16
Fang Jiang, Yang Xiang, Li-Na Guo
A 30-year-old Chinese woman with irregular vaginal bleeding was admitted to our department. Serum β-human chorionic gonadotropin (β-hCG) was moderately elevated, and ultrasound and magnetic resonance imaging revealed an irregular, retro-uterine lesion without intrauterine pregnancy. Ectopic pregnancy was the primary consideration, with trophoblastic tumor being another possibility. Laparoscopy revealed a 2 × 3 × 3 cm3 irregular, infiltrating, yellow-white lesion in the left recto-uterine pouch, which was completely resected without rectal damage...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29434245/galectin-3-plays-an-important-role-in-preterm-birth-caused-by-dental-infection-of-porphyromonas-gingivalis
#17
Mutsumi Miyauchi, Min Ao, Hisako Furusho, Chanbora Chea, Atsuhiro Nagasaki, Shinnichi Sakamoto, Toshinori Ando, Toshihiro Inubushi, Katsuyuki Kozai, Takashi Takata
Dental infection is risk for preterm birth (PTB) through unclear mechanisms. We established a dental infection-induced PTB mouse model, in which Porphyromonas gingivalis (P.g.) induced PTB by 2 days. We analysed pathogenic factors contributing to PTB and their effects on trophoblasts in vitro. TNF-α, IL-8, and COX-2 were upregulated in P.g.-infected placenta. Galectin-3 (Gal-3), an immune regulator, was significantly upregulated in placenta, amniotic fluid, and serum. In vitro, P.g.-lipopolysaccharide (P.g...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432428/plac1-as-a-serum-biomarker-for-breast-cancer
#18
Hongyan Yuan, Vincent Chen, Marc Boisvert, Claudine Isaacs, Robert I Glazer
Placental-specific protein 1 (PLAC1) is an X-linked trophoblast gene that is re-expressed in several malignancies, including breast cancer, and is therefore a potential biomarker to follow disease onset and progression. Sera from 117 preoperative/pretreatment breast cancer patients and 51 control subjects, including those with fibrocystic disease, were analyzed for the presence of PLAC1 protein as well as its expression by IHC in tumor biopsies in a subset of subjects. Serum PLAC1 levels exceeded the mean plus one standard deviation (mean+SD) of the level in control subjects in 67% of subjects with ductal carcinoma in situ (DCIS), 67% with HER2+ tumors, 73% with triple-negative cancer and 73% with ER+/PR+ tumors...
2018: PloS One
https://www.readbyqxmd.com/read/29428958/down-regulation-of-neuropathy-target-esterase-in-preeclampsia-placenta-inhibits-human-trophoblast-cell-invasion-via-modulating-mmp-9-levels
#19
Ting Zhong, Jiaxiang Chen, Yan Ling, Bei Yang, Xingxing Xie, Dainan Yu, Dalei Zhang, Jiexiu Ouyang, Haibin Kuang
BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Recently; studies showed that artificial phosphatidylserine/PC microvesicles can induce preeclampsia (PE)-like changes in pregnant mice. However, it is unclear whether NTE plays a key role in the pathology of PE, a pregnancy-related disease, which was characterized by deficient trophoblast invasion and reduced trophoblast-mediated remodeling of spiral arteries...
February 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29427369/pre-eclampsia-affects-procalcitonin-production-in-placental-tissue
#20
Chiara Agostinis, Damiano Rami, Paola Zacchi, Fleur Bossi, Tamara Stampalija, Alessandro Mangogna, Leonardo Amadio, Romana Vidergar, Liza Vecchi Brumatti, Giuseppe Ricci, Claudio Celeghini, Oriano Radillo, Ian Sargent, Roberta Bulla
PROBLEM: Procalcitonin (PCT) is the prohormone of calcitonin which is usually released from neuroendocrine cells of the thyroid gland (parafollicular) and the lungs (K cells). PCT is synthesized by almost all cell types and tissues, including monocytes and parenchymal tissue, upon LPS stimulation. To date, there is no evidence for PCT expression in the placenta both in physiological and pathological conditions. METHOD: Circulating and placental PCT levels were analysed in pre-eclamptic (PE) and control patients...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
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