keyword
MENU ▼
Read by QxMD icon Read
search

Urocortins

keyword
https://www.readbyqxmd.com/read/27832152/urocortin-treatment-improves-acute-hemodynamic-instability-and-reduces-myocardial-damage-in-post-cardiac-arrest-myocardial-dysfunction
#1
Chien-Hua Huang, Chih-Hung Wang, Min-Shan Tsai, Nai-Tan Hsu, Chih-Yen Chiang, Tzung-Dau Wang, Wei-Tien Chang, Huei-Wen Chen, Wen-Jone Chen
AIMS: Hemodynamic instability occurs following cardiac arrest and is associated with high mortality during the post-cardiac period. Urocortin is a novel peptide and a member of the corticotrophin-releasing factor family. Urocortin has the potential to improve acute cardiac dysfunction, as well as to reduce the myocardial damage sustained after ischemia reperfusion injury. The effects of urocortin in post-cardiac arrest myocardial dysfunction remain unclear. METHODS AND RESULTS: We developed a preclinical cardiac arrest model and investigated the effects of urocortin...
2016: PloS One
https://www.readbyqxmd.com/read/27826101/serotonin-and-urocortin-1-in-the-dorsal-raphe-and-edinger-westphal-nuclei-after-early-life-stress-in-serotonin-transporter-knockout-rats
#2
Rick H A van der Doelen, Berit Robroch, Ilse A Arnoldussen, Maya Schulpen, Judith R Homberg, Tamás Kozicz
The interaction of early life stress (ELS) and the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) has been associated with increased risk to develop depression in later life. We have used the maternal separation paradigm as a model for ELS exposure in homozygous and heterozygous 5-HTT knockout rats and measured urocortin 1 (Ucn1) mRNA and/or protein levels, Ucn1 DNA methylation, as well as 5-HT innervation in the centrally projecting Edinger-Westphal (EWcp) and dorsal raphe (DR) nuclei, both implicated in the regulation of stress response...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27818644/an-update-on-crf-mechanisms-underlying-alcohol-use-disorders-and-dependence
#3
REVIEW
Isabel Marian Hartmann Quadros, Giovana Camila Macedo, Liz Paola Domingues, Cristiane Aparecida Favoretto
Alcohol is the most commonly used and abused substance worldwide. The emergence of alcohol use disorders, and alcohol dependence in particular, is accompanied by functional changes in brain reward and stress systems, which contribute to escalated alcohol drinking and seeking. Corticotropin-releasing factor (CRF) systems have been critically implied in the transition toward problematic alcohol drinking and alcohol dependence. This review will discuss how dysregulation of CRF function contributes to the vulnerability for escalated alcohol drinking and other consequences of alcohol consumption, based on preclinical evidence...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27777046/crh-peptide-evolution-occurred-in-three-phases-evidence-from-characterizing-sea-lamprey-crh-system-members
#4
Matthew J Endsin, Ola Michalec, Lori A Manzon, David A Lovejoy, Richard G Manzon
The corticotropin releasing hormone (CRH) system, which includes the CRH family of peptides, their receptors (CRHRs) and a binding protein (CRHBP), has been strongly conserved throughout vertebrate evolution. The identification of invertebrate homologues suggests this system evolved over 500 million years ago. However, the early vertebrate evolution of the CRH system is not understood. Current theory indicates that agnathans (hagfishes and lampreys) are monophyletic with a conservative evolution over the past 500million years and occupy a position at the root of vertebrate phylogeny...
January 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27757017/intracerebroventricular-urocortin-3-counteracts-central-acyl-ghrelin-induced-hyperphagic-and-gastroprokinetic-effects-via-crf-receptor-2-in-rats
#5
Chun Yeh, Ching-Heng Ting, Ming-Luen Doong, Chin-Wen Chi, Shou-Dong Lee, Chih-Yen Chen
PURPOSE: Urocortin 3 is a key neuromodulator in the regulation of stress, anxiety, food intake, gut motility, and energy homeostasis, while ghrelin elicits feeding behavior and enhances gastric emptying, adiposity, and positive energy balance. However, the interplays between urocortin 3 and ghrelin on food intake and gastric emptying remain uninvestigated. METHODS: We examined the differential effects of central O-n-octanoylated ghrelin, des-Gln(14)-ghrelin, and urocortin 3 on food intake, as well as on charcoal nonnutrient semiliquid gastric emptying in conscious rats that were chronically implanted with intracerebroventricular (ICV) catheters...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27754786/cardiac-crfr1-expression-is-elevated-in-human-heart-failure-and-modulated-by-genetic-variation-and-alternative-splicing
#6
Anna P Pilbrow, Kathy A Lewis, Marilyn H Perrin, Wendy E Sweet, Christine S Moravec, W H Wilson Tang, Mark O Huising, Richard W Troughton, Vicky A Cameron
Corticotropin-releasing factor (CRF) and the CRF-related peptides, urocortin (Ucn)-1, Ucn2, and Ucn3 signal through receptors CRFR1 and CRFR2 to restore homeostasis in response to stress. The Ucns exert potent cardioprotective effects and may have clinical utility in heart failure. To explore the activity of this system in the heart, we measured the levels of myocardial gene expression of the CRF/Ucn family of ligands/receptors and investigated genetic variation and alternative splicing of CRFR1 in 110 heart failure patients and 108 heart donors...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27702653/ucn-enhances-tgf-beta-mediated-mitoinhibition-of-vsmcs-via-counteracting-tgf-beta-induced-cpla2-expression-and-activation
#7
Chao Zhu, Changchun Cao, Xiaofei Wang, Jie Yuan, Lai Jin, Shengnan Li
Urocortins (UCNs) and transforming growth factor-beta (TGF-beta) have been demonstrated to participate in various cardiovascular diseases, many of which involve vascular smooth muscle cells (VSMCs) proliferation. Cytosolic phospholipase A2 (cPLA2)-mediated arachidonic acid (AA) release is an important cause of VSMCs proliferation. The work was to investigate the regulation of VSMCs proliferation by UCN/TGF-beta and whether cPLA2 was a link between their signaling pathways. VSMCs proliferation was measured by colorimetric assay and immunofluorescence microscopy...
October 1, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27699250/one-time-injection-of-aav8-encoding-urocortin-2-provides-long-term-resolution-of-insulin-resistance
#8
Mei Hua Gao, Dimosthenis Giamouridis, N Chin Lai, Evelyn Walenta, Vivian Almeida Paschoal, Young Chul Kim, Atsushi Miyanohara, Tracy Guo, Min Liao, Li Liu, Zhen Tan, Theodore P Ciaraldi, Simon Schenk, Aditi Bhargava, Da Young Oh, H Kirk Hammond
Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injection of AAV8.UCn2-normalized blood glucose and glucose disposal within weeks, an effect that lasted for months. Hyperinsulinemic-euglycemic clamps showed reduced plasma insulin, increased glucose disposal rates, and increased insulin sensitivity following UCn2 gene transfer...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27693397/selective-crf2-receptor-agonists-ameliorate-the-anxiety-and-depression-like-state-developed-during-chronic-nicotine-treatment-and-consequent-acute-withdrawal-in-mice
#9
Zsolt Bagosi, Miklós Palotai, Balázs Simon, Péter Bokor, András Buzás, Beáta Balangó, Dávid Pintér, Miklós Jászberényi, Krisztina Csabafi, Gyula Szabó
The aim of the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by acute nicotine withdrawal in mice. In order to do so, male CFLP mice were exposed for 7 days to repeated intraperitoneal (IP) injection with nicotine or saline solution and 1day of acute withdrawal and then a single intracerebroventricular (ICV) injection with UCN 2, UCN 3 or saline solution...
September 29, 2016: Brain Research
https://www.readbyqxmd.com/read/27667703/intraperitoneal-injection-urocortin-3-reduces-the-food-intake-of-siberian-sturgeon-acipenser-baerii
#10
Xin Zhang, Yuanbing Wu, Jin Hao, Jieyao Zhu, Ni Tang, Jinwen Qi, Shuyao Wang, Hong Wang, Shuang Peng, Ju Liu, Yundi Gao, Defang Chen, Zhiqiong Li
Urocortin-3 (UCN3), one of the corticotropin releasing factor (CRF) family peptides, which was discovered in 2001, has a variety of biological functions. However, the researches of UCN3 in fish were scarce. In order to understand whether UCN3 play a role in regulating food intake in fish, we first cloned the ucn3 cDNAs sequence of Siberian sturgeon (Acipenser baerii Brandt), and investigated the ucn3 mRNA levels in 11 tissues. The Siberian sturgeon ucn3 cDNA sequence was 1044bp, including an open reading frame (ORF) of 447bp that encoded 148 amino acids with a mature peptide of 40 amino acids, a 5'-terminal untranslated region (5'-UTR) of 162bp and a 3'-terminal untranslated region (3'-UTR) of 435bp...
September 22, 2016: Peptides
https://www.readbyqxmd.com/read/27659706/characterization-of-urocortin-as-an-anti-apoptotic-protein-in-experimental-ischemia-reperfusion-model-of-the-rat-testis
#11
Kenta Sumii, Hideaki Miyake, Noritoshi Enatsu, Koji Chiba, Masato Fujisawa
The objective of this study was to investigate the role of urocortin in testicular apoptosis using an experimental ischemia-reperfusion rat model. To evaluate the change in urocortin expression and apoptotic status in the testes following ischemia-reperfusion, the left testes of rats were rotated clockwise by 720° for 1 h, and were then harvested at 0, 1, 3, 6 and 24 h after detorsion (n = 5 in each group). A time-dependent increase in the expression levels of urocortin was noted until 6 h after reperfusion, but the expression of urocortin was markedly decreased 24 h after reperfusion...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27658512/involvement-of-the-blood-brain-barrier-in-metabolic-regulation
#12
Abba J Kastin, Weihong Pan
Pertinent to pandemic obesity, the discovery of endogenous peptides that affect the ingestion of food has led to the question of how these ingestive peptides exert their actions in the brain. Whereas peripheral sources provide a ready reserve, the availability of ingestive peptides to their central nervous system targets can be regulated by the blood-brain barrier (BBB). Some of the peptides/polypeptides are transported by saturable mechanisms from blood to brain. Examples include leptin, insulin, mahogany, and pancreatic polypeptide...
September 20, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27648432/utility-of-the-pediatric-sleep-questionnaire-and-urocortin-level-in-urine-as-screening-tools-in-pediatric-patients-with-suspected-obstructive-sleep-apnea-syndrome
#13
Esengul Keleş, Arzu Gebeşçe, Filiz Turan, Fatma Fidan, Hamza Yazgan, Bülent Baştürk, Mehmet Demirdöven, Alparslan Tonbul, Mahmut Kaya
No abstract text is available yet for this article.
June 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27586075/region-specific-roles-of-the-corticotropin-releasing-factor-urocortin-system-in-stress
#14
Marloes J A G Henckens, Jan M Deussing, Alon Chen
Dysregulation of the corticotropin-releasing factor (CRF)-urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF-CRF receptor type 1 (CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery and the restoration of homeostasis. Recent findings, however, provide clear evidence that this view is overly simplistic. Instead, a more complex picture has emerged that suggests that there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges...
October 2016: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/27567427/urocortin-and-corticotrophin-releasing-hormone-receptor-type-2-mrna-are-highly-expressed-in-deep-infiltrating-endometriotic-lesions
#15
Patrizia Carrarelli, Alice Luddi, Lucia Funghi, Felice Arcuri, Frederic Batteux, Cynthia Dela Cruz, Claudia Tosti, Fernando M Reis, Charles Chapron, Felice Petraglia
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) are the most severe forms of endometriosis, but different pathogenetic mechanisms and clinical symptoms distinguish these two forms. Corticotrophin-releasing hormone (CRH) and urocortin (Ucn) are endometrial neuropeptides involved in tissue differentiation and inflammation. The expression of CRH, Ucn, Ucn2, CRH-receptors (type-1 and type-2) and inflammatory enzymes phospholipase-A2 group IIA (PLA2G2A) and cycloxygenase-2 (COX2) were evaluated in OMA (n = 22) and DIE (n = 26)...
October 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27550842/crf-receptor-type-2-neurons-in-the-posterior-bed-nucleus-of-the-stria-terminalis-critically-contribute-to-stress-recovery
#16
M J A G Henckens, Y Printz, U Shamgar, J Dine, M Lebow, Y Drori, C Kuehne, A Kolarz, M Eder, J M Deussing, N J Justice, O Yizhar, A Chen
The bed nucleus of the stria terminalis (BNST) is critical in mediating states of anxiety, and its dysfunction has been linked to stress-related mental disease. Although the anxiety-related role of distinct subregions of the anterior BNST was recently reported, little is known about the contribution of the posterior BNST (pBNST) to the behavioral and neuroendocrine responses to stress. Previously, we observed abnormal expression of corticotropin-releasing factor receptor type 2 (CRFR2) to be associated with post-traumatic stress disorder (PTSD)-like symptoms...
August 23, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27524410/bioactive-forms-of-vitamin-d-selectively-stimulate-the-skin-analog-of-the-hypothalamus-pituitary-adrenal-axis-in-human-epidermal-keratinocytes
#17
Justyna M Wierzbicka, Michał A Żmijewski, Anna Piotrowska, Boguslaw Nedoszytko, Magdalena Lange, Robert C Tuckey, Andrzej T Slominski
Ultraviolet radiation B stimulates both the production of vitamin D3 in the skin and the activation of the skin analog of the hypothalamic-pituitary-adrenal axis (HPA) as well as the central HPA. Since the role of vitamin D3 in the regulation of the HPA is largely unknown, we investigated the impact of 1,25(OH)2D3 and its noncalcemic analogs, 20(OH)D3 and 21(OH)pD, on the expression of the local HPA in human epidermal keratinocytes. The noncalcemic analogs showed similar efficacy to 1,25(OH)2D3 in stimulating the expression of neuropeptides, CRF, urocortins and POMC, and their receptors, CRFR1, CRFR2, MC1R, MC2R, MC3R and MC4R...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27492720/dynamic-expression-of-corticotropin-releasing-hormone-and-urocortin-in-estrogen-induced-cholestasis-pregnant-rat
#18
Fan Zhou, Bingxin Gao, Chunyan Deng, Guiqiong Huang, Ting Xu, Xiaodong Wang
Intrahepatic cholestasis of pregnancy(ICP) is complicated by acute placental-fetal hypoxia. Corticotropin-releasing hormone(CRH) and urocortin(UCN) are vasodilatory regulators of blood flow in the placenta. An ethinylestradiol(EE)-induced cholestasis rat model was reproduced and serum/placental CRH/UCN were detected during 14-21days of gestation(DG). Maternal serum or placental CRH/UCN levels in the control rats were relatively consistent during 14-21DG. Serum CRH was reduced in the EE-treated rats compared with the control rats at 21DG...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27458591/role-of-urocortin-in-pregnancy-an-update-and-future-perspectives
#19
REVIEW
Salvatore Giovanni Vitale, Antonio Simone Laganà, Agnese Maria Chiara Rapisarda, Maria Giovanna Scarale, Francesco Corrado, Pietro Cignini, Salvatore Butticè, Diego Rossetti
The activities of corticotropin-releasing factor (CRF) and related peptides are mediated a number of receptors with seven transmembrane domains that are coupled to the Gs and Gq proteins. These receptors are known as CRF-Rs. In vitro studies have evidenced that urocortin (UCN) and CRF provoke an increase in the contractility of the uterus which is induced by endometrial prostaglandin F2a. Furthermore, through trophoblasts, it stimulates the secretion of adrenocorticotropic hormone (ACTH) and prostaglandin PGE2 and has a vasodilatory effect on the placenta...
July 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27440813/expression-of-inflammatory-and-neurogenic-mediators-in-adenomyosis-a-pathogenetic-role
#20
Patrizia Carrarelli, Chih-Feng Yen, Lucia Funghi, Felice Arcuri, Claudia Tosti, Giuseppe Bifulco, Alice Luddi, Chyi-Long Lee, Felice Petraglia
OBJECTIVE: Adenomyosis is a uterine disorder characterized by dysmenorrhea, dyspareunia, abnormal uterine bleeding, and infertility. Pathogenesis indicates that endometrial cells invade and proliferate within myometrium, and inflammatory mediators participate to the intense painful symptoms. The aim of the present study was to investigate the messenger RNA (mRNA) and protein expression of inflammatory (interleukin 1β [IL-1β], corticotropin-releasing hormone [CRH], urocortin [Ucn]) and neurogenic (nerve growth factors [NGFs], synaptophysin [SYN], microtubule-associated protein 2 [MAP2]) factors in adenomyotic nodules...
July 20, 2016: Reproductive Sciences
keyword
keyword
49353
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"