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Corticotrophin releasing hormone

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https://www.readbyqxmd.com/read/29138567/resveratrol-ameliorates-chronic-unpredictable-mild-stress-induced-depression-like-behavior-involvement-of-the-hpa-axis-inflammatory-markers-bdnf-and-wnt-%C3%AE-catenin-pathway-in-rats
#1
Xin-Hua Yang, Su-Qi Song, Yun Xu
Classic antidepressant drugs are modestly effective across the population and most are associated with intolerable side effects. Recently, numerous lines of evidence suggest that resveratrol (RES), a natural polyphenol, possesses beneficial therapeutic activity for depression. The aim of the present study was to explore whether RES exhibits an antidepressant-like effect in a depression model and to explore the possible mechanism. A depression model was established via chronic unpredictable mild stress (CUMS), after which the model rats in the RES and fluoxetine groups received a daily injection of RES or fluoxetine, respectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29079226/unraveling-vasotocinergic-isotocinergic-and-stress-pathways-after-food-deprivation-and-high-stocking-density-in-the-gilthead-sea-bream
#2
Arleta Krystyna Skrzynska, Juan Antonio Martos-Sitcha, Gonzalo Martínez-Rodríguez, Juan Miguel Mancera
The influence of chronic stress, induced by food deprivation (FD) and/or high stocking density (HSD), was assessed on stress, vasotocinergic and isotocinergic pathways of the gilthead sea bream (Sparus aurata). Fish were randomly assigned to one of the following treatments: (1) fed at low stocking density (LSD-F; 5kg·m(-3)); (2) fed at high stocking density (HSD-F, 40kg·m(-3)); (3) food-deprived at LSD (LSD-FD); and (4) food-deprived at HSD (HSD-FD). After 21days, samples from plasma, liver, hypothalamus, pituitary and head-kidney were collected...
October 24, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29021740/electroacupuncture-alleviates-surgical-trauma-induced-hypothalamus-pituitary-adrenal-axis-hyperactivity-via-microrna-142
#3
Jing Zhu, Zhejun Chen, Zehui Meng, Minda Ju, Mizhen Zhang, Gencheng Wu, Haidong Guo, Zhanzhuang Tian
Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatectomy induced an HPA axis disorder and EA application could regulate the hypothalamic CRH. We first demonstrated that microRNAs (miRNAs) target on CRH via bioinformatics analysis and screened them in the primary hypothalamic neurons...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28958685/saikosaponin-a-attenuates-perimenopausal-depression-like-symptoms-by-chronic-unpredictable-mild-stress
#4
Xue-Qin Chen, Shu-Jiao Chen, Wen-Na Liang, Miao Wang, Cheng-Fu Li, Shuang-Shuang Wang, Shu-Qi Dong, Li-Tao Yi, Can-Dong Li
Accumulating studies have shown that a traditional Chinese decoction Chaihu-Shugan-San produced the antidepressant-like effects in rodents including in perimenopausal. Previous studies and our preliminary study indicated that saikosaponin A, one of the main constituents of Chaihu-Shugan-San, enhanced brain-derived neurotrophic factor (BDNF) expression in rats. Herein, this study aimed to evaluate the antidepressant-like effects of saikosaponin A in perimenopausal rats exposed to chronic unpredictable mild stress (CUMS)...
September 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28932185/hyperactivity-of-hypothalamic-pituitary-adrenal-axis-due-to-dysfunction-of-the-hypothalamic-glucocorticoid-receptor-in-sigma-1-receptor-knockout-mice
#5
Tingting Di, Suyun Zhang, Juan Hong, Tingting Zhang, Ling Chen
Sigma-1 receptor knockout (σ1R-KO) mice exhibit a depressive-like phenotype. Because σ1R is highly expressed in the neuronal cells of hypothalamic paraventricular nuclei (PVN), this study investigated the influence of σ1R deficiency on the regulation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Here, we show that the levels of basal serum corticosterone (CORT), adrenocorticotropic hormone (ACTH) and corticotrophin releasing factor (CRF) as well as the level of CRF mRNA in PVN did not significantly differ between adult male σ1R-KO mice and wild-type (WT) mice...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28845039/preoperative-and-postoperative-pituitary-function-in-patients-with-tuberculum-sellae-meningioma-based-on-pituitary-provocation-tests
#6
Shingo Fujio, Hirofumi Hirano, Mami Yamashita, Satoshi Usui, Yasuyuki Kinoshita, Atsushi Tominaga, Tomoko Hanada, Hitoshi Yamahata, Hiroshi Tokimura, Ryosuke Hanaya, Kaoru Kurisu, Kazunori Arita
Given the anatomical proximity of tuberculum sellae meningioma (TSM) to the hypothalamo-pituitary system, pituitary function impairments are of great concern. We retrospectively investigated pituitary function changes following surgery in patients with TSM using pituitary provocation tests (PPTs). Thirty-one patients (27 females and 4 males) with TSM underwent initial transcranial surgery (29 patients) or transsphenoidal surgery (two patients); surgeries were performed carefully to avoid injuring the pituitary stalk...
October 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28795329/copeptin-as-a-marker-of-an-altered-crh-axis-in-pituitary-disease
#7
Krzysztof C Lewandowski, Andrzej Lewiński, Elżbieta Skowrońska-Jóźwiak, Katarzyna Malicka, Wojciech Horzelski, Georg Brabant
BACKGROUND: Copeptin (pre-proAVP) secreted in equimolar amounts with vasopressin closely reflects vasopressin release. Copeptin has been shown to subtly mirror stress potentially mediated via corticotrophin-releasing hormone. To further test a potential direct interaction of corticotrophin-releasing hormone with copeptin release, which could augment vasopressin effects on pituitary function, we investigated copeptin response to corticotrophin-releasing hormone. PATIENTS AND METHODS: Cortisol, adrenocorticotropin and copeptin were measured in 18 healthy controls and 29 subjects with a history of pituitary disease during standard corticotrophin-releasing hormone test...
September 2017: Endocrine
https://www.readbyqxmd.com/read/28782547/early-life-stress-increases-testosterone-and-corticosterone-and-alters-stress-physiology-in-zebra-finches
#8
J Bayley Zito, Angy Hanna, Nora Kadoo, Michelle L Tomaszycki
Early life stress has enduring effects on behavior and physiology. However, the effects on hormones and stress physiology remain poorly understood. In the present study, parents of zebra finches of both sexes were exposed to an increased foraging paradigm from 3 to 33days post hatching. Plasma and brains were collected from chicks at 3 developmental time points: post hatching days 25, 60 and adulthood. Plasma was assayed for testosterone (T), estradiol (E2), and corticosterone (CORT). The paraventricular nucleus of the hypothalamus was assessed for corticotrophin releasing factor (CRH) and glucocorticoid receptor (GR) expression...
August 15, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28718999/resilience-is-decreased-in-irritable-bowel-syndrome-and-associated-with-symptoms-and-cortisol-response
#9
S H Park, B D Naliboff, W Shih, A P Presson, E J Videlock, T Ju, L Kilpatrick, A Gupta, E A Mayer, L Chang
BACKGROUND: Irritable bowel syndrome (IBS) is a stress-sensitive disorder associated with early adverse life events (EALs) and a dysregulated hypothalamic-pituitary-adrenal (HPA) axis. Resilience is the ability to recover and adapt positively to stress but has not been well studied in IBS. The aims of this study are to compare resilience in IBS and healthy controls (HCs) and to assess its relationships with IBS symptom severity, quality of life (QOL), EALs, and HPA axis response. METHODS: Two hundred fifty-six subjects (154 IBS, 102 HCs) completed questionnaires for resilience (Connor-Davidson Resilience Scale [CD-RISC] and Brief Resilience Scale [BRS]), IBS symptoms, IBS-QOL, and EALs...
July 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28692683/contribution-of-molecular-analysis-to-the-typification-of-the-non-functioning-pituitary-adenomas
#10
Laura Sanchez-Tejada, Ruth Sanchez-Ortiga, Cristina Lamas, Rosa Camara, Pedro Riesgo, Carmen Fajardo, Francisco Ignacio Aranda, Antonio Pico
AIM: The WHO Classification of Tumours of Endocrine Organs considers the inmunohistochemical characterization of pituitary adenomas (PA) as mandatory for patient diagnosis. Recent advances in the knowledge of the molecular patterns of these tumours could complement this classification with gene expression profiling. METHODS: Within the context of the Spanish Molecular Registry of Pituitary Adenomas (REMAH), a multicentre clinical-basic research project, we analysed the molecular phenotype of 142 PAs with complete IHC and clinical information...
2017: PloS One
https://www.readbyqxmd.com/read/28687926/atat1-is-essential-for-regulation-of-homeostasis-retaining-cellular-responses-in-corticotrophs-along-hypothalamic-pituitary-adrenal-axis
#11
Takashi Nakakura, Takeshi Suzuki, Seiji Torii, Anshin Asano-Hoshino, Yoko Nekooki-Machida, Hideyuki Tanaka, Kenjiro Arisawa, Yoshimi Nishijima, Takao Susa, Tomoki Okazaki, Yoshiko Kiuchi, Haruo Hagiwara
The production and secretion of adrenocorticotropin, a proopiomelanocortin (POMC)-derived hormone, by corticotrophs in the anterior pituitary, is regulated by corticotrophin-releasing hormone (CRH) and glucocorticoids. We have previously demonstrated that adrenalectomy induces α-tubulin N-acetyltransferase 1 (ATAT1) expression and α-tubulin acetylation in corticotrophs. However, the regulatory mechanism of ATAT1 expression and the function of acetylated microtubules in corticotrophs are unclear. Here, we analyze the effect of CRH or dexamethasone on Atat1 expression in the mouse corticotroph AtT20 cell line...
July 7, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28635080/neuroadaptations-of-presynaptic-and-postsynaptic-gabab-receptor-function-in-the-paraventricular-nucleus-in-response-to-chronic-unpredictable-stress
#12
Yonggang Gao, Jing-Jing Zhou, Yun Zhu, Li Wang, Therese A Kosten, Xiangjian Zhang, De-Pei Li
BACKGROUND AND PURPOSE: Chronic stress impairs GABAA (GABA type A) receptor-mediated inhibition in the hypothalamic paraventricular nucleus (PVN). It is not clear whether GABAB receptor function is also altered. We hypothesize that chronic stress alters GABAB receptor function in PVN corticotrophin-releasing hormone (CRH) neurons to control hypothalamus-pituitary-adrenal axis activity. EXPERIMENTAL APPROACH: Whole-cell patch clamp recordings were made of PVN-CRH neurons expressing eGFP driven by CRH promoter in brain slices from unstressed rats and rats exposed to chronic unpredictable mild stress (CUMS)...
September 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28626863/prolactin-correction-for-adequacy-of-petrosal-sinus-cannulation-may-diminish-diagnostic-accuracy-in-cushing-s-disease
#13
Sunita M C De Sousa, Ann I McCormack, Shaun McGrath, David J Torpy
OBJECTIVE: Petrosal venous prolactin concentrations have been promoted to improve the diagnostic accuracy of inferior petrosal sinus sampling (IPSS), beyond that achieved with ACTH measurement alone, in diagnosing a pituitary ACTH source and determining corticotrophinoma side (L/R). Our objective was to assess the effect of using prolactin to confirm adequacy of petrosal cannulation in a cohort of patients with ACTH-dependent Cushing's syndrome. DESIGN: Retrospective cohort study...
November 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28618089/crh-promotes-human-colon-cancer-cell-proliferation-via-il-6-jak2-stat3-signaling-pathway-and-vegf-induced-tumor-angiogenesis
#14
Xianjun Fang, Yali Hong, Li Dai, Yuanyuan Qian, Chao Zhu, Biao Wu, Shengnan Li
Corticotrophin-releasing hormone (CRH) has been demonstrated to participate in various diseases. Our previous study showed that its receptor CRHR1 mediated the development of colitis-associated cancer in mouse model. However, the detailed mechanisms remain unclear. In this study, we explored the oncogenetic role of CRH/CRHR1 signaling in colon cancer cells. Cell proliferation and colony formation assays revealed that CRH contributed to cell proliferation. Moreover, tube formation assay showed that CRH-treated colon cancer cell supernatant significantly promoted tube formation of human umbilical vein endothelial cells (HUVECs)...
November 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28591825/corticotrophin-releasing-hormone-and-corticosterone-impair-development-of-preimplantation-embryos-by-inducing-oviductal-cell-apoptosis-via-activating-the-fas-system-an-in-vitro-study
#15
Xiu-Wen Tan, Chang-Li Ji, Liang-Liang Zheng, Jie Zhang, Hong-Jie Yuan, Shuai Gong, Jiang Zhu, Jing-He Tan
STUDY QUESTION: What are the mechanisms by which corticotrophin-releasing hormone (CRH) and corticosterone impair the development of preimplantation embryos in the oviduct. SUMMARY ANSWER: CRH and corticosterone do not affect preimplantation embryos directly, but impair their development indirectly by triggering apoptosis of oviductal epithelial cells (OECs) through activation of the Fas system. WHAT IS KNOWN ALREADY: Studies report that stress impairs embryo development with facilitated secretion of CRH and glucocorticoids...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28572045/the-integration-of-multiple-signaling-pathways-provides-for-bidirectional-control-of-crhr1-gene-transcription-in-rat-pituitary-cell-during-hypoxia
#16
Yan Jun Shi, Zhi Qiang Ma, Jia Wei Tang, Yang Zhao, Xi Wang, Qing Liu, Ping Ping Wang, Coote John, Xue Qun Chen, Ji Zeng Du
Hypoxia upregulates hypothalamic corticotrophin releasing hormone (CRH) and its receptor type-1 (CRHR1) expression and activates the HPA axis and induces hypoxic sickness and behavioral change. The transcriptional mechanism by which hypoxia differently regulates CRHR1 expression remains unclear. Here we report hypoxia time-dependently induced biphasic expression of CRHR1mRNA in rat pituitary during different physiological status. Short exposure of gestational dams to hypoxia reduced CRHR1mRNA in the pituitary of P1-P14 male rat offspring...
October 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28508690/gene-polymorphisms-associated-with-temperament
#17
Xiaoyan Qiu, Graeme B Martin, Dominique Blache
When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of temperament, as well as personality, psychological disorders and behavioral traits, are influenced by genetic factors, and much of the variation appears to involve variation in genes or gene polymorphisms in the hypothalamic-pituitary-adrenocortical (HPA) axis and the behavior-controlling neurotransmitter networks...
May 16, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28469557/modulation-of-the-hypothalamic-pituitary-adrenal-axis-by-early-life-stress-exposure
#18
REVIEW
Miranda van Bodegom, Judith R Homberg, Marloes J A G Henckens
Exposure to stress during critical periods in development can have severe long-term consequences, increasing overall risk on psychopathology. One of the key stress response systems mediating these long-term effects of stress is the hypothalamic-pituitary-adrenal (HPA) axis; a cascade of central and peripheral events resulting in the release of corticosteroids from the adrenal glands. Activation of the HPA-axis affects brain functioning to ensure a proper behavioral response to the stressor, but stress-induced (mal)adaptation of the HPA-axis' functional maturation may provide a mechanistic basis for the altered stress susceptibility later in life...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28467477/waterborne-exposure-to-bps-causes-thyroid-endocrine-disruption-in-zebrafish-larvae
#19
Dan-Hua Zhang, En-Xiang Zhou, Zhu-Lin Yang
Bisphenol S (BPS) is widely used as a raw material in industry, resulting in its ubiquitous distribution in natural environment, including the aqueous environment. However, the effect of BPS on the thyroid endocrine system is largely unknown. In this study, zebrafish (Danio rerio) embryos were exposed to BPS at 1, 3, 10, and 30 μg/L, from 2 h post-fertilization (hpf) to 168hpf. Bioconcentration of BPS and whole-body thyroid hormones (THs), thyroid-stimulating hormone (TSH) concentrations as well as transcriptional profiling of key genes related to the hypothalamic-pituitary-thyroid (HPT) axis were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28423630/insufficient-hypothalamic-angiotensin-converting-enzyme-2-is-associated-with-hypertension-in-shr-rats
#20
Kun Wang, Yuanyuan Xu, Weiwei Yang, Yuanshu Zhang
Angiotensin-Converting Enzyme 2 (ACE2) is a key enzyme in the renin-angiotensin system (RAS), which is implicated in the pathogenesis of hypertension and other cardiovascular diseases. In this study we investigated the expression of ACE2 in the hypothalamus and pituitary tissues and its relationship to hypertension by comparing them in male WKY and SHR rats. We observed that the plasma levels of corticotrophin releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and aldosterone (ALD) were all lower in SHR than WKY rats (P<0...
March 21, 2017: Oncotarget
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