keyword
https://read.qxmd.com/read/38437640/coassembly-nanomedicine-mediated-by-intermolecular-interactions-between-methotrexate-and-baricitinib-for-improved-rheumatoid-arthritis-treatment
#21
JOURNAL ARTICLE
Hehe Xiong, Heng Zhang, Yatong Qin, Jinmin Ye, Fantian Zeng, Peng Xie, Changrong Shi, Changyuan Luo, Weizhuo Xu, Chunyang Yu, Zijian Zhou, Xiaoyuan Chen
The combination of anti-rheumatoid arthritis (RA) drugs methotrexate (MTX) and baricitinib (BTN) has been reported to improve RA treatment efficacy. However, study on the strategy of combination is elusive when considering the benefit of the synergy between MTX and BTN. In this study, we found that the N-heterocyclic rings in the MTX and BTN offer hydrogen bonds and π-π stacking interactions, driving the formation of exquisite vesicular morphology of nanovesicles, denoted as MB NVs. The MB NVs with the MTX/BTN weight ratio of 2:1, MB NVs (2:1), showed an improved anti-RA effect through the synergy between the anti-inflammatory and antiproliferative responses...
March 4, 2024: ACS Nano
https://read.qxmd.com/read/38435753/-kaempferia-parviflora-extracellular-vesicle-loaded-with-clarithromycin-for-the-treatment-of-helicobacter-pylori-infection
#22
JOURNAL ARTICLE
Variya Nemidkanam, Wijit Banlunara, Nuntaree Chaichanawongsaroj
PURPOSE: Kaempferia parviflora extracellular vesicles (KPEVs) have been reported as promising nanovesicles for drug delivery. This study aimed to load clarithromycin (CLA) into KPEVs (KPEVS-CLA) and determine the physical properties, drug-releasing efficiency, gastric cell uptake, anti- H. pylori activities, and anti-inflammatory responses in comparison with free CLA and KPEVs. METHODS: The size and surface charge of KPEVs-CLA were evaluated using dynamic light scattering and visualized using a transmission electron microscope...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38434148/tailoring-therapeutics-via-a-systematic-beneficial-elements-comparison-between-photosynthetic-bacteria-derived-omvs-and-extruded-nanovesicles
#23
JOURNAL ARTICLE
Tingshan Xiao, Yichuan Ma, Ziyang Zhang, Yixin Zhang, Yu Zhao, Xiaohan Zhou, Xueyi Wang, Kun Ge, Junshu Guo, Jinchao Zhang, Zhenhua Li, Huifang Liu
Photosynthetic bacteria (PSB) has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant properties. Nevertheless, the actualization of their potential is impeded by inherent constraints, including their considerable size, heightened immunogenicity and compromised biosafety. Conquering these obstacles and pursuing more effective solutions remains a top priority. Similar to extracellular vesicles, bacterial outer membrane vesicles (OMVs) have demonstrated a great potential in biomedical applications...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38430518/protocol-to-produce-plant-based-hybrid-nanovesicles-from-fresh-turmeric-and-pepper-using-polyethylene-glycol
#24
JOURNAL ARTICLE
Meghana N Kumar, Sreeram Peringattu Kalarikkal, Yashaswini Jayaram, Janakiraman Narayanan, Gopinath M Sundaram
In addition to proteins, microRNAs, and lipids, plant-derived exosome-like nanovesicles (ENVs) are also enriched with host plant bioactives. Both curcumin and piperine are water insoluble, lack bioavailability, and are extracted by non-ecofriendly solvents. Herein, we present an eco-friendly protocol for co-isolating both curcumin and piperine in the form of hybrid ENVs. We describe steps for sample pre-processing, combined homogenization of plant materials, filtration, and differential centrifugation. We then detail procedures for polyethylene glycol-based fusion and precipitation of hybrid ENVs...
February 29, 2024: STAR protocols
https://read.qxmd.com/read/38428139/isolation-of-serum-derived-placental-amniochorionic-extracellular-vesicles-across-pregnancy-by-immunoaffinity-using-plap-and-hla-g
#25
JOURNAL ARTICLE
Uma Shinde, Aishwarya Rao, Vandana Bansal, Dhanjit Kumar Das, Nafisa Huseni Balasinor, Taruna Madan
Extracellular vesicles (EVs) are membrane-bound nanovesicles secreted from the cells into extracellular space and body fluids. They are considered "fingerprints of parent cells" which can reflect their physiological and functional states. During pregnancy, extracellular vesicles (EVs) are produced by the syncytiotrophoblasts and extravillous trophoblasts and are released into the maternal bloodstream. In the present study, placental alkaline phosphatase (PLAP)-specific extracellular vesicles were isolated from maternal serum-derived EVs (SDE) across pregnancy...
February 1, 2024: Reproduction
https://read.qxmd.com/read/38420893/nanovesicular-ultraflexible-invasomes-and-invasomal-gel-for-transdermal-delivery-of-phytopharmaceuticals
#26
EDITORIAL
Alakh N Sahu, Debadatta Mohapatra, Pratap Chandra Acharya
Tweetable abstract Invasomes and invasomal gel are ultraflexible, soft vesicular, phospholipid based nanocarriers with deeper skin penetration ability for transdermal applications of drugs and phytopharmaceuticals.
February 29, 2024: Nanomedicine
https://read.qxmd.com/read/38415544/investigation-of-in-vitro-anti-cancer-and-apoptotic-potential-of-garlic-derived-nanovesicles-against-prostate-and-cervical-cancer-cell-lines
#27
JOURNAL ARTICLE
Vinayak Sharma, Eshu Singhal Sinha, Jagtar Singh
OBJECTIVE: Investigate the anti-cancerous potential of garlic-derived nanovesicles (GDNVs), exploring their cytotoxic effects on HeLa and PC-3 cell lines, and elucidate the underlying mechanisms, including apoptosis induction and inhibition of epithelial-mesenchymal transition (EMT). METHODS: GDNVs were isolated using differential centrifugation and ultracentrifugation. Characterization was performed through dynamic light scattering (DLS), field-emission scanning electron microscopy (FESEM), and Fourier-transform infrared spectroscopy (FTIR)...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38414031/inhalable-hybrid-nanovaccines-with-virus-biomimetic-structure-boost-protective-immune-responses-against-sars-cov-2-variants
#28
JOURNAL ARTICLE
Shuqi Wang, Peiyang Ding, Lingli Shen, Daopeng Fan, Hanghang Cheng, Jian Huo, Xin Wei, Hua He, Gaiping Zhang
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different antigenic variants, has posed a significant threat to public health. It is urgent to develop inhalable vaccines, instead of injectable vaccines, to elicit mucosal immunity against respiratory viral infections. METHODS: We reported an inhalable hybrid nanovaccine (NVRBD -MLipo) to boost protective immunity against SARS-CoV-2 infection. Nanovesicles derived from genetically engineered 293T cells expressing RBD (NVRBD ) were fused with pulmonary surfactant (PS)-biomimetic liposomes containing MPLA (MLipo) to yield NVRBD -MLipo, which possessed virus-biomimetic structure, inherited RBD expression and versatile properties...
February 27, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38410418/characterization-of-nanohybridosomes-from-lipids-and-spruce-homogenate-containing-extracellular-vesicles
#29
JOURNAL ARTICLE
Vesna Spasovski, Anna Romolo, Urška Zagorc, Vesna Arrigler, Matic Kisovec, Apolonija Bedina Zavec, Matevž Arko, Adrienn Molnár, Gitta Schlosser, Aleš Iglič, Ksenija Kogej, Veronika Kralj-Iglič
INTRODUCTION: Lipid nanovesicles associated with bioactive phytochemicals from spruce needle homogenate (here called nano-sized hybridosomes or nanohybridosomes, NSHs) were considered. METHODS: We formed NSHs by mixing appropriate amounts of lecithin, glycerol and supernatant of isolation of extracellular vesicles from spruce needle homogenate. We visualized NSHs by light microscopy and cryogenic transmission electron microscopy and assessed them by flow cytometry, dynamic light scattering, ultraviolet-visual spectroscopy, interferometric light microscopy and liquid chromatography-mass spectrometry...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38406605/anticipation-and-verification-of-dendrobium-derived-nanovesicles-for-skin-wound-healing-targets-predicated-upon-immune-infiltration-and-senescence
#30
JOURNAL ARTICLE
Jin Tu, Feng Jiang, Jieni Fang, Luhua Xu, Zhicong Zeng, Xuanyue Zhang, Li Ba, Hanjiao Liu, Fengxia Lin
BACKGROUND: Dendrobium , with profound botanical importance, reveals a rich composition of bioactive compounds, including polysaccharides, flavonoids, alkaloids, and diverse amino acids, holding promise for skin regeneration. However, the precise mechanism remains elusive. Seeking a potent natural remedy for wound healing, exocyst vesicles were successfully isolated from Dendrobium . AIMS OF THE STUDY: This investigation aimed to employ bioinformatics and in vivo experiments to elucidate target genes of Dendrobium -derived nanovesicles in skin wound healing, focusing on immune infiltration and senescence characteristics...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38400717/imaging-of-isolated-exosomes-by-correlative-microscopy
#31
JOURNAL ARTICLE
Şeyda Demir, Esra Erdal, Hüsnü Alper Bagriyanik
Correlative microscopy is a sophisticated imaging technique that combines optical and electron microscopes, with the most common approach being the integration of light microscopy and electron microscopy, known as correlative light and electron microscopy (CLEM). While CLEM provides a comprehensive view of biological samples, it presents a significant challenge in sample preparation due to the distinct processes involved in each technique. Striking a balance between these methods is crucial. Despite numerous approaches, achieving seamless imaging with CLEM remains a complex task...
February 24, 2024: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://read.qxmd.com/read/38399321/the-evolution-of-emerging-nanovesicle-technologies-for-enhanced-delivery-of-molecules-into-and-across-the-skin
#32
REVIEW
Elka Touitou, Hiba Natsheh
This review focuses on nanovesicular carriers for enhanced delivery of molecules into and across the skin, from their design to recent emerging technologies. During the last four decades, several approaches have been used aiming to design new nanovesicles, some of them by altering the properties of the classic phospholipid vesicle, the liposome. Phospholipid nanovesicular systems, including the phospholipid soft vesicles as well as the non-phospholipid vesicular carries, are reviewed. The altered nanovesicles have served in the manufacture of various cosmetic products and have been investigated and used for the treatment of a wide variety of skin conditions...
February 13, 2024: Pharmaceutics
https://read.qxmd.com/read/38387516/macrophage-membrane-camouflaged-biomimetic-nanovesicles-for-targeted-treatment-of-arthritis
#33
REVIEW
Xin Huang, Weiyue Zhang
Arthritis has become the most common joint disease globally. Current attention has shifted towards preventing the disease and exploring pharmaceutical and surgical treatments for early-stage arthritis. M2 macrophages are known for their anti-inflammatory properties and their ability to support cartilage repair, offering relief from arthritis. Whereas, it remains a great challenge to promote the beneficial secretion of M2 macrophages to prevent the progression of arthritis. Therefore, it is warranted to investigate new strategies that could use the functions of M2 macrophages and enhance its therapeutic effects...
February 20, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38374774/exploring-contemporary-breakthroughs-in-utilizing-vesicular-nanocarriers-for-breast-cancer-therapy
#34
REVIEW
Nalla Usha Kumari, Ekta Pardhi, Padakanti Sandeep Chary, Neelesh Kumar Mehra
Breast cancer (BC) is a heterogeneous disease with various morphological features, clinicopathological conditions and responses to different therapeutic options, which is responsible for high mortality and morbidity in women. The heterogeneity of BC necessitates new strategies for diagnosis and treatment, which is possible only by cautious harmonization of the advanced nanomaterials. Recent developments in vesicular nanocarrier therapy indicate a paradigm shift in breast cancer treatment by providing an integrated approach to address current issues...
February 20, 2024: Therapeutic Delivery
https://read.qxmd.com/read/38369472/link-between-organic-nanovescicles-from-vegetable-kingdom-and-human-cell-physiology-intracellular-calcium-signalling
#35
JOURNAL ARTICLE
Martina Trentini, Ilaria Zanolla, Elena Tiengo, Federica Zanotti, Eduardo Sommella, Fabrizio Merciai, Pietro Campiglia, Danilo Licastro, Margherita Degasperi, Luca Lovatti, Massimo Bonora, Alberto Danese, Paolo Pinton, Barbara Zavan
BACKGROUND: Plant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring their functions and potential applications. Among fruits, apples (sp. Malus domestica) have great potential as PDNVs source, given their widespread consumption, substantial waste production, and recognized health benefits. Notably, apple-derived nanovesicles (ADNVs) can interact with human cell lines, triggering anti-inflammatory and antioxidant responses. This work is dedicated to the comprehensive biochemical characterization of apple-derived nanovesicles (ADNVs) through proteomic and lipidomic analysis, and small RNAs sequencing...
February 19, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38358374/therapeutic-restoration-of-mir-126-3p-as-a-multi-targeted-strategy-to-modulate-the-liver-tumor-microenvironment
#36
JOURNAL ARTICLE
Piyush Gondaliya, Julia Driscoll, Irene K Yan, Adil Ali Sayyed, Tushar Patel
BACKGROUND: Impaired natural killer (NK) cell-mediated antitumor responses contribute to the growth of liver tumors. Expression of a disintegrin and metalloprotease 9 (ADAM9) increases shedding of membrane-bound major histocompatibility complex class I chain-related protein A and results in evasion from NK cell-mediated cytolysis. ADAM9 is also involved in angiogenesis and tumor progression and is a target of miR-126-3p, a tumor suppressor that is downregulated and alters tumor cell behavior in the liver and other cancers...
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38357804/lipid-nanovesicle-platforms-for-hepatocellular-carcinoma-precision-medicine-therapeutics-progress-and-perspectives
#37
REVIEW
Brandon M Lehrich, Evan R Delgado
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Current therapeutic options, including immune checkpoint inhibitors and combinations, have achieved limited objective response rates for the majority of patients. Thus, a precision medicine approach is needed to tailor specific treatment options for molecular subsets of HCC patients...
December 31, 2024: Organogenesis
https://read.qxmd.com/read/38349328/garlic-derived-exosome-like-nanovesicles-based-wound-dressing-for-staphylococcus-aureus-infection-visualization-and-treatment
#38
JOURNAL ARTICLE
Sisi Zhou, Puzhen Huang, Yu Cao, Xin Hua, Yao Yang, Songqin Liu
Garlic-derived exosome-like nanovesicles (GELNs) could function in interspecies communication and may serve as natural therapeutics to regulate the inflammatory response or as nanocarriers to efficiently deliver specific drugs. Staphylococcus aureus ( S. aureus ) is able to hide within host cells to evade immune clearance and antibiotics, leading to life-threatening infections. On-site detection and efficient treatment of intracellular S. aureus infection in wounds remain challenging. Herein, we report a thermosensitive, injectable, visible GELNs-based wound dressing, Van@GELNs/F127 hydrogel (gel Van@GELNs), which is H2 O2 -responsive and can slowly release vancomycin into host cells for S...
February 13, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38348717/exosomal-circ_0037104-derived-from-hu-mscs-inhibits-cholangiocarcinoma-progression-by-sponging-mir-620-and-targeting-afap1
#39
JOURNAL ARTICLE
Zilin Yuan, Ba Xiong, Lie Liu, Yifan Lu, Yueping Liu, Gang Wang, Yang Qian, Bo Diao, Mingzhong Tu
Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as circular RNAs (circRNAs) and microRNAs (miRNAs), between different cells. Human umbilical cord-derived mesenchymal stem cells (Hu-MSCs) can migrate to tumor sites and exert complex functions throughout tumor progression. In this study, we successfully isolated Hu-MSCs from human umbilical cords based on their surface marker expression. Hu-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of cholangiocarcinoma (CCA) cells...
February 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38345214/a-magnetic-separation-assisted-high-speed-homogenization-method-for-large-scale-production-of-endosome-derived-vesicles
#40
JOURNAL ARTICLE
Dujuan Wang, Shili Yao, Peng Guo
Extracellular vesicles (EVs) have attracted significant attention in physiological and pathological research, disease diagnosis, and treatment; however, their clinical translation has been limited by the lack of scale-up manufacturing approaches. Therefore, this protocol provides a magnetic separation-assisted high-speed homogenization method for the large-scale production of endosome-derived nanovesicles as a new type of exosome mimics (EMs) derived from the endosomes, which have about 100-time higher yield than conventional ultracentrifugation method...
January 26, 2024: Journal of Visualized Experiments: JoVE
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