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Nnamdi Uhegwu, Asif Bashir, Haitham Dababneh, Mohammed Hussain, Sara Misthal, J Duffy Mocco
Fentanyl is a potent opioid used commonly in acute care because of its rapid onset and short duration of action. It has fewer side effects when compared with commonly available opioids, such as morphine and hydromorphine. We report an unusual side effect of transient aphasia following fentanyl administration. A 61-year-old female presented for an elective embolization of a periophthalmic artery aneurysm. She developed immediate episodes of aphasia on two separate occasions following administration of intravenous (IV) fentanyl...
February 2015: Journal of Vascular and Interventional Neurology
A K Claude, A Dedeaux, L Chiavaccini, S Hinz
BACKGROUND: Vomiting is a common complication associated with the use of hydromorphine for pre-emptive analgesia in dogs. The ideal anti-emetic protocol for prevention of this complication has not been established. HYPOTHESIS: Maropitant administered concurrently or before hydromorphone would reduce the incidence of vomiting, signs of nausea, ptyalism, and increased panting compared to administration of acepromazine or a 0.9% saline control. ANIMALS: Sixty mixed-breed female dogs scheduled for ovariohysterectomy...
September 2014: Journal of Veterinary Internal Medicine
K E Clemens, E Klaschik
BACKGROUND AND OBJECTIVE: Dyspnoea frequently occurs in patients with advanced tumor disease receiving palliative care (prevalence > 50). Aim of the study was to assess, in dyspneic patients in palliative care, the efficacy of opioids in treating their dyspnoea and to determine whether or not nasal administration of oxygen previous to opioid administration would decrease the severity of dyspnoea. PATIENTS AND METHODS: In a prospective, non-randomised study 25 patients with cancer who had been admitted to our palliative care unit were investigated (aged 64...
September 2007: Deutsche Medizinische Wochenschrift
Ahmed I Al-Asmari, Robert A Anderson
A method using liquid chromatography-electrospray ionization-tandem mass spectrometry was developed and validated for the determination of morphine, codeine, hydromorphone, dihydrocodeine, oxycodone, buprenorphine, and naloxone with their metabolites morphine-3-glucuronide, morphine-6-glucuronide, normorphine, 6-acetylmorphine, 6-acetylcodeine, codeine-6-glucuronide, norcodeine, hydromorphine-3-glucuronide, dihydrocodeine-6-glucuronide, dihydromorphine, dihydromorphine-3-glucuronide, dihydromorphine-6-glucuronide, oxymorphone, norbuprenorphine, buprenorphine-3-glucuronide, norbuprenorphine-3-glucuronide, and naloxone-3-glucuronide in human whole blood...
September 2007: Journal of Analytical Toxicology
P Udén, L Rentzhog, T Berger
In a prospective study, including fifty consecutive patients with acute ureteral-stone pain, the patients were randomly distributed into two groups for treatment. There were given either an intravenous injection of indomethacin (Confortid) 50 mg, or a subcutaneous injection of 2 mg hydromorphine chloride-atropine (Dilaudid-atropin 1 ml). Patients in the latter group also received a suppository of prochlorperazine (Stemetil) 25 mg. The analgesic effect of the two drugs did not differ significantly. Indomethacin was quicker acting, probably due to the intravenous route of administration...
1983: Acta Chirurgica Scandinavica
J P Monk, R Beresford, A Ward
Sufentanil, an opioid analgesic, is an analogue of fentanyl, and has been used for the induction and maintenance of anaesthesia, and for postsurgical analgesia. It has shorter distribution and elimination half-lives, and is a more potent analgesic than fentanyl. In clinical practice, however, intravenously administered sufentanil produces essentially equivalent anaesthesia to fentanyl and is a better anaesthetic than morphine or pethidine (meperidine) for major surgery. It would appear to maintain haemodynamic stability during surgery better than other opioids or inhalational anaesthetics...
September 1988: Drugs
A P Smith, H H Loh
Of the three primary sub-cellular fractions derived from mouse brain homogenates, the P3 (microsomal) fraction binds 3H-di-hydromorphine stereo-specifically with the highest capacity per mg. of protein; this level is nearly as great as that bound by purified synaptosomal plasma membranes (SPM). The binding to P3 is unlikely to be attributable to contamination with SPM, because a) ten times as much total binding is recovered in P3 as in SPM, and b) the level of binding to P3 is highest in a sub-fraction banding above 0...
October 1976: Research Communications in Chemical Pathology and Pharmacology
A P Smith
High-affinity, in vitro stereospecific binding of 3H-di-hydromorphine or 3H-naloxone to brain membranes shows a marked dependence on pH; maximal binding, observed at pH 7.5-8.0, is abruptly and reversibly reduced as the pH is lowered, with the binding half-maximal at about pH 6.8. A similar pH dependence of stereospecific binding is observed with the quaternary agonist N-methyl morphine, but non-specific 3H-di-hydromorphine of 3H-naloxone binding (that not displaced by a 100-fold excess of unlabelled levorphanol) shows only a slight decrease in this pH range...
July 1977: Research Communications in Chemical Pathology and Pharmacology
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