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https://www.readbyqxmd.com/read/27909528/influence-of-inter-electrode-atrial-lead-distance-on-acapconfirm%C3%A2-viability
#1
Lapuerta Irigoyen J A, Valverde Andre I, Vigil Escalera P, Gonzalez Vasserot M
Introduction: The AcapConfirm™ feature available with the Zephyr pacemaker family (St. Jude Medical) is designed for monitoring patient's atrial capture threshold periodically, and automatically adjusting the atrial pulse amplitude. Previous studies showed a relative low proportion of patients at three months follow-up with recommended automatic atrial capture after the AcapConfirm™ viability test. The purpose of the present study is to evaluate the effect of inter electrode distance on the viability of the AcapConfirm™ algorithm...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909501/-two-for-the-price-of-one-a-single-lead-implantable-cardioverter-defibrillator-system-with-a-floating-atrial-dipole
#2
REVIEW
Nicole E Worden Md, Musab Alqasrawi Md, Siva M Krothapalli Md, Alexander Mazur Md
In patients known to be a high risk for sudden cardiac arrest, implantable cardioverter defibrillators (ICD) are a proven therapy to reduce risk of death. However, in patients without conventional indications for pacing, the optimal strategy for type of device, dual- versus single-chamber, remains debatable. The benefit of prophylactic pacing in this category of patients has never been documented. Although available atrial electrograms in a dual chamber system improve interpretation of stored arrhythmia events, allow monitoring of atrial fibrillation and may potentially reduce the risk of inappropriate shocks by enhancing automated arrhythmia discrimination, the use of dual-chamber ICDs has a number of disadvantages...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908579/transient-elastography-in-patients-with-implanted-cardiac-rhythm-devices
#3
Mireen Friedrich-Rust, Fabian Schoelzel, Sven Linzbach, Joerg Bojunga, Stefan Zeuzem, Florian Seeger
BACKGROUND: At present the use of transient elastography (TE) in patients with pacemaker (PM) or implantable cardioverter defibrillator (ICD) devices is not recommended, since the safety due to the electromagnet embarked in the vibrator for producing the shearwave has not been evaluated. However, no adverse events of sonographic examinations in this patient group have been reported. AIMS: The aim of the present study was to evaluate the safety of TE in patients with PM or ICD...
November 17, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27908067/lateralization-of-interaural-timing-differences-with-multi-electrode-stimulation-in-bilateral-cochlear-implant-users
#4
Alan Kan, Heath G Jones, Ruth Y Litovsky
Bilateral cochlear implant (BiCI) users have shown variability in interaural time difference (ITD) sensitivity at different places along the cochlea. This paper investigates perception of multi-electrode binaural stimulation to determine if auditory object formation (AOF) and lateralization are affected by variability in ITD sensitivity when a complex sound is encoded with multi-channel processing. AOF and ITD lateralization were compared between single- and multi-electrode configurations. Most (7/8) BiCI users perceived a single auditory object with multi-electrode stimulation, and the range of lateralization was comparable to single-electrode stimulation, suggesting that variability in single-electrode ITD sensitivity does not compromise AOF with multi-electrode stimulation...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27905012/microbial-proteins-as-novel-industrial-biotechnology-hosts-to-treat-epilepsy
#5
REVIEW
Zareen Amtul, Amal A Aziz
Epilepsy is characterized by the hyperexcitability of various neuronal circuits that results due to the imbalance between glutamate-mediated excitation of voltage-gated cation channels and γ-amino butyric acid (GABA)-mediated inhibition of anion channels leading to aberrant, sporadic oscillations or fluctuations in neuronal electrical activity. Epilepsy with a risk of mortality and around 65 million sufferers of all ages all over the world is limited therapeutically with high rates of adverse reactions, lack of complete seizure control, and over 30% patients with refractory epilepsy...
December 1, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27901096/image-based-in-vivo-assessment-of-targeting-accuracy-of-stereotactic-brain-surgery-in-experimental-rodent-models
#6
Janaki Raman Rangarajan, Greetje Vande Velde, Friso van Gent, Philippe De Vloo, Tom Dresselaers, Maarten Depypere, Kris van Kuyck, Bart Nuttin, Uwe Himmelreich, Frederik Maes
Stereotactic neurosurgery is used in pre-clinical research of neurological and psychiatric disorders in experimental rat and mouse models to engraft a needle or electrode at a pre-defined location in the brain. However, inaccurate targeting may confound the results of such experiments. In contrast to the clinical practice, inaccurate targeting in rodents remains usually unnoticed until assessed by ex vivo end-point histology. We here propose a workflow for in vivo assessment of stereotactic targeting accuracy in small animal studies based on multi-modal post-operative imaging...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900949/prediction-of-cortical-responses-to-simultaneous-electrical-stimulation-of-the-retina
#7
Kerry J Halupka, Mohit N Shivdasani, Shaun L Cloherty, David B Grayden, Yan T Wong, Anthony N Burkitt, Hamish Meffin
OBJECTIVE: Simultaneous electrical stimulation of multiple electrodes has shown promise in diversifying the responses that can be elicited by retinal prostheses compared to interleaved single electrode stimulation. However, the effects of interactions between electrodes are not well understood and clinical trials with simultaneous stimulation have produced inconsistent results. We investigated the effects of multiple electrode stimulation of the retina by developing a model of cortical responses to retinal stimulation...
November 30, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27900916/electrically-evoked-compound-action-potentials-are-different-depending-on-the-site-of-cochlear-stimulation
#8
Paul van de Heyning, Santiago L Arauz, Marcus Atlas, Wolf-Dieter Baumgartner, Marco Caversaccio, Ronel Chester-Browne, Patricia Estienne, Javier Gavilan, Benoit Godey, Wolfgang Gstöttner, Demin Han, Rudolph Hagen, Martin Kompis, Vlad Kuzovkov, Luis Lassaletta, Franc Lefevre, Yongxin Li, Joachim Müller, Lorne Parnes, Andrea Kleine Punte, Christopher Raine, Gunesh Rajan, Adriana Rivas, José Antonio Rivas, Nicola Royle, Georg Sprinzl, Kurt Stephan, Adam Walkowiak, Yuri Yanov, Kim Zimmermann, Patrick Zorowka, Henryk Skarzynski
One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea...
November 30, 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27900329/postinsertional-cable-movements-of-cochlear-implant-electrodes-and-their-effects-on-intracochlear-pressure
#9
I Todt, D Karimi, J Luger, A Ernst, P Mittmann
Introduction. To achieve a functional atraumatic cochlear implantation, intracochlear pressure changes during the procedure should be minimized. Postinsertional cable movements are assumed to induce intracochlear pressure changes. The aim of this study was to observe intracochlear pressure changes due to postinsertional cable movements. Materials and Methods. Intracochlear pressure changes were recorded in a cochlear model with a micro-pressure sensor positioned in the apical region of the cochlea model to follow the maximum amplitude and pressure gain velocity in intracochlear pressure...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27899291/dynamic-changes-in-sleep-pattern-during-post-partum-in-normal-pregnancy-in-rat-model
#10
Neelima Sivadas, Arathi Radhakrishnan, B S Aswathy, Velayudhan Mohan Kumar, Kamalesh K Gulia
To develop an animal model for studies on peri-partum sleep disorders, sleep patterns in female Wistar rats during pregnancy, post-partum and after weaning, were assessed and associated adaptive changes in their anxiety were examined. Adult nulliparous female rats, maintained in standard laboratory conditions with ad libitum food and water, were surgically implanted with electroencephalogram and electromyogram electrodes under anaesthesia for objective assessment of sleep-wakefulness (S-W). After post-surgical recovery, three control recordings of S-W were taken for 24h before the animals were kept for mating...
November 26, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27898605/initial-results-of-a-safety-and-feasibility-study-of-auditory-brainstem-implantation-in-congenitally-deaf-children
#11
Eric P Wilkinson, Laurie S Eisenberg, Mark D Krieger, Marc S Schwartz, Margaret Winter, Jamie L Glater, Amy S Martinez, Laurel M Fisher, Robert V Shannon
OBJECTIVE: To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency. STUDY DESIGN: Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period. SETTING: Tertiary children's hospital and university-based pediatric speech/language/hearing center. INTERVENTION(S): ABI implantation and postsurgical programming...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27894944/surface-projected-flair-supr-flair-analysis-a-novel-tool-for-advanced-imaging-of-epilepsy
#12
Francesco Cardinale, Stefano Francione, Luciana Gennari, Alberto Citterio, Maurizio Sberna, Laura Tassi, Roberto Mai, Ivana Sartori, Lino Nobili, Massimo Cossu, Laura Castana, Giorgio Lo Russo, Nadia Colombo
OBJECTIVE: The objective of this pilot retrospective study is to describe the SUrface-PRojected FLuid-Attenuation-Inversion-Recovery (SUPR-FLAIR) analysis, a novel method mainly aimed at revealing cortical areas with subtle signal hyper-intensity. METHODS: Images from 101 healthy controls and ten patients suffering from drug-resistant partial epilepsy were retrospectively post-processed. Brain surface was reconstructed from a 3D T1-weighted fast field echo (3D T1W-FFE) MRI scan...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27893396/enhanced-control-of-cortical-pyramidal-neurons-with-micro-magnetic-stimulation
#13
Seung Woo Lee, Shelley Fried
Magnetic stimulation is less sensitive to the inflammatory reactions that plague conventional electrode-based cortical implants and therefore may be useful as a next-generation (implanted) cortical prosthetic. The fields arising from micro-coils are quite small however and thus, their ability to modulate cortical activity must first be established. Here, we show that layer V pyramidal neurons (PNs) can be strongly activated by micro-coil stimulation and further, the asymmetric fields arising from such coils do not simultaneously activate horizontally -oriented axon fibers, thus confining activation to a focal region around the coil...
November 22, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27893099/electrically-evoked-responses-in-the-rabbit-cortex-induced-by-current-steering-with-penetrating-optic-nerve-electrodes
#14
Yan Yan, Yiliang Lu, Menghui Li, Zengguang Ma, Pengjia Cao, Yao Chen, Xiaodong Sun, Xinyu Chai, Qiushi Ren, Liming Li
Purpose: Current steering is a neural stimulation strategy that uses simultaneous stimulation of adjacent electrodes to produce additional intermediate stimulation sites and thus improves spatial resolution. We investigated the feasibility of current steering using electrophysiological and computational methods after implanting paired penetrating electrodes into the rabbit's optic nerve (ON). Methods: Penetrating electrodes at different interelectrode distances were implanted into the ON and electrically evoked cortical potentials (EEPs) in V1 recorded with a 6 × 8 array...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27891705/spinal-cord-stimulation-in-experimental-chronic-painful-diabetic-polyneuropathy-delayed-effect-of-high-frequency-stimulation
#15
M van Beek, M van Kleef, B Linderoth, S M J van Kuijk, W M Honig, E A Joosten
BACKGROUND: Spinal cord stimulation (SCS) has been shown to provide pain relief in painful diabetic polyneuropathy (PDPN). As the vasculature system plays a great role in the pathophysiology of PDPN, a potential beneficial side-effect of SCS is peripheral vasodilation, with high frequency (HF) SCS in particular. We hypothesize that HF-SCS (500 Hz), compared with conventional (CON) or low frequency (LF)-SCS will result in increased alleviation of mechanical hypersensitivity in chronic experimental PDPN...
November 28, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27889580/methylphenidate-modulates-dorsal-raphe-neuronal-activity-behavioral-and-neuronal-recordings-from-adolescent-rats
#16
Holly Whitt, Natasha Kharas, Nachum Dafny
Methylphenidate (MPD) is a widely prescribed psychostimulants used for the treatment of attention deficit hyperactive disorder (ADHD). Unlike the psychostimulants cocaine and amphetamine, MPD does not exhibit direct actions on the serotonin transporter, however there is evidence suggesting that the therapeutic effects of MPD may be mediated in part by alterations in serotonin transmission. This study aimed to investigate the role of the dorsal raphe (DR) nucleus, one of the major sources of serotonergic innervation in the mammalian brain, in the response to MPD exposure...
November 23, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27889333/magnetoencephalography-meg-past-current-and-future-perspectives-for-improved-differentiation-and-treatment-of-epilepsies
#17
Hermann Stefan, Eugen Trinka
In addition to visual analysis digital computerized recording of electrical and magnetic fields by using EEG and MEG opened a new window for research concerning improved understanding of pathophysiology, diagnosis and treatment of epilepsies. In the last 25 years MEG was used more and more in clinical studies concerning localization of focal epileptic activity, functional cortex and network analysis. Simultaneous MEG/EEG recording and analysis offer the use of complimentary information increasing the sensitivity for tracing primary epileptic activity...
November 15, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27885980/a-revision-surgery-for-cochlear-implantation-in-a-case-of-incomplete-partition-type-i
#18
Habib G Rizk, Francesca Hagood, Meredith A Holcomb, Ted A Meyer
BACKGROUND: Patients with cochlear malformations were long considered poor candidates for cochlear implantation (CI), and surgical approaches different than the standard facial recess approach were used to access the inner ear. There is no previous long-term follow-up of a patient with significantly malformed inner ear operated through an untraditional route and requiring a revision surgery. PURPOSE: This case provides a long-term follow-up from the initial surgery, a short-term follow-up from the revision surgery, and it illustrates the evolving classification of inner ear malformations as well as the potential problems associated with nonstandard approaches to the cochlea...
November 2016: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/27881723/intraspinal-microstimulation-and-diaphragm-activation-following-cervical-spinal-cord-injury
#19
Lynne M Mercier, Elisa J Gonzalez-Rothi, Kristi A Streeter, Savannah S Posgai, Alexander S Poirier, David D Fuller, Paul J Reier, David M Baekey
Intraspinal microstimulation (ISMS), using implanted electrodes, can evoke locomotor movements after spinal cord injury (SCI), but has not been explored in the context of respiratory motor output. An advantage over epidural and direct muscle stimulation is the potential of ISMS to selectively stimulate components of the spinal respiratory network. The present study tested the hypothesis that medullary respiratory activity could be used to trigger mid-cervical ISMS and diaphragm motor unit activation in rats with cervical SCI...
November 23, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27879487/electrocochleography-in-cochlear-implant-recipients-with-residual-hearing-comparison-with-audiometric-thresholds
#20
Kanthaiah Koka, Aniket A Saoji, Leonid M Litvak
OBJECTIVES: To determine whether electrocochleography (ECoG) thresholds, especially cochlear microphonic and auditory nerve neurophonic thresholds, measured using an intracochlear electrode, can be used to predict pure-tone audiometric thresholds following cochlear implantation in ears with residual hearing. DESIGN: Pure-tone audiometric thresholds and ECoG waveforms were measured at test frequencies from 125 to 4000 Hz in 21 Advanced Bionics cochlear implant recipients with residual hearing in the implanted ear...
November 22, 2016: Ear and Hearing
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