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https://www.readbyqxmd.com/read/29928951/higher-serum-levels-of-pro-hepcidin-in-patients-with-parkinson-s-disease-treated-with-deep-brain-stimulation
#1
J Kwiatek-Majkusiak, M Geremek, D Koziorowski, R Tomasiuk, S Szlufik, A Friedman
Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6. It can therefore be regarded as a link between the oxidative stress processes, where iron plays an important role, and the processes of neuroinflammation - both considered to be responsible for the neurodegeneration in Parkinson's disease. We assessed the serum level of pro-hepcidin in patients with Parkinson's disease treated only pharmacologically and those treated additionally with deep brain stimulation (DBS) as compared to the control group...
June 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29923505/optogenetic-entrainment-of-neural-oscillations-with-hybrid-fiber-probes
#2
Antje Kilias, Andres Canales, Ulrich P Froriep, Seongjun Park, Ulrich Egert, Polina Anikeeva
Optogenetic modulation of neural activity is a ubiquitous tool for basic investigation of brain circuits. While the majority of optogenetic paradigms rely on short light pulses to evoke synchronized activity of optically sensitized cells, many neurobiological processes are associated with slow local field potential (LFP) oscillations. Therefore, we developed a hybrid fiber probe capable of simultaneous electrophysiological recording and optical stimulation and used it to investigate the utility of sinusoidal light stimulation for evoking oscillatory neural activity in vivo across a broad frequency range...
June 20, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29922565/neuroma-implantation-into-long-bones-clinical-foundation-for-a-novel-osseointegrated-peripheral-nerve-interface
#3
Jacqueline S Israel, Aaron M Dingle, Ruston J Sanchez, Sahil K Kapur, Sarah Brodnick, Thomas J Richner, Jared P Ness, Joseph Novello, Justin C Williams, Samuel O Poore
Symptomatic neuroma after major extremity amputation is a challenging clinical problem for which there are many described treatment options. Neuroma excision and implantation into the medullary canal of long bones offers durability and insulation, and minimizes chronic pain. Another challenge in amputees is impaired function and an ongoing need for accessible and functional prostheses that are "bidirectional," in that they provide both fine motor control and sensory feedback. Drawing on clinical experience with neuroma implantation into the medullary canal of long bones, the authors propose a novel neural interface whereby a terminal nerve end is redirected into the medullary canal of a nearby long bone and interfaced with an electrode array...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29921762/tb-ii-i-a-fraction-isolated-from-tityus-bahiensis-scorpion-venom-alters-cytokines-level-and-induces-seizures-when-intrahippocampally-injected-in-rats
#4
Emidio Beraldo Neto, Douglas O C Mariano, Lucas A Freitas, Ana L C Dorce, Adriana N Martins, Daniel C Pimenta, Fernanda C V Portaro, Daniela Cajado-Carvalho, Valquiria A C Dorce, Ana L A Nencioni
Scorpion venoms are composed of several substances with different pharmacological activities. Neurotoxins exert their effects by targeting ion channels resulting in toxic effects to mammals, insects and crustaceans. Tb II-I, a fraction isolated from Tityus bahiensis scorpion venom, was investigated for its ability to induce neurological and immune-inflammatory effects. Two putative β-sodium channel toxins were identified in this fraction, Tb2 II and Tb 4, the latter having been completely sequenced by mass spectrometry...
June 19, 2018: Toxins
https://www.readbyqxmd.com/read/29920586/determining-the-rotational-orientation-of-directional-deep-brain-stimulation-leads-employing-flat-panel-computed-tomography
#5
Stefan Hunsche, Clemens Neudorfer, Faycal El Majdoub, Mohammad Maarouf, Dieter Sauner
BACKGROUND: Directional deep brain stimulation (DBS) constitutes an emerging technology that allows selective stimulation of target structures via partitioned electrode contacts. In order to effectively perform target-tailored stimulation, knowledge of the rotational orientation of the segmented leads is imperative. OBJECTIVE: To develop a universally applicable and reliable method for determination of lead orientation angles in DBS using flat-panel computed tomography (fpCT)...
June 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29920373/gridloc-an-automatic-and-unsupervised-localization-method-for-high-density-ecog-grids
#6
Mariana P Branco, Michael Leibbrand, Mariska J Vansteensel, Zachary V Freudenburg, Nick F Ramsey
Precise localization of electrodes is essential in the field of high-density (HD) electrocorticography (ECoG) brain signal analysis in order to accurately interpret the recorded activity in relation to functional anatomy. Current localization methods for subchronically implanted HD electrode grids involve post-operative imaging. However, for situations where post-operative imaging is not available, such as during acute measurements in awake surgery, electrode localization is complicated. Intra-operative photographs may be informative, but not for electrode grids positioned partially or fully under the skull...
June 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29916770/investigation-of-subdural-electrode-displacement-in-invasive-epilepsy-surgery-workup-using-neuronavigation-and-intraoperative-mri
#7
Bjoern Sommer, Stefan Rampp, Arnd Doerfler, Hermann Stefan, Hajo M Hamer, Michael Buchfelder, Karl Roessler
OBJECTIVES: One of the main obstacles of electrode implantation in epilepsy surgery is the electrode shift between implantation and the day of explantation. We evaluated this possible electrode displacement using intraoperative MRI (iopMRI) data and CT/MRI reconstruction. METHODS: Thirteen patients (nine female, four male, median age 26 ± 9.4 years) suffering from drug-resistant epilepsy were examined. After implantation, the position of subdural electrodes was evaluated by 3...
June 19, 2018: Neurological Research
https://www.readbyqxmd.com/read/29916398/feasibility-study-for-a-glutamate-driven-subretinal-prosthesis-local-subretinal-application-of-glutamate-on-blind-retina-evoke-network-mediated-responses-in-different-types-of-ganglion-cells
#8
Wadood Haq, Johannes Dietter, Sylvia Bolz, Eberhart Zrenner
OBJECTIVE: A feasibility study for a transmitter based subretinal prosthesis, generating visual responses in blind mouse retina is presented. APPROACH: Degenerated rd1 mouse retina were stimulated in subretinal configuration by local glutamate (Glu) or NMDA application via micropipettes (~1.5 μm) and thereby the outer retinal activity was recorded by calcium-imaging or the ganglion cell (GC) activity was recorded by the multi-electrode array system. The network mediated activation of GC via bipolar cells was approved by the administration of Glu receptor blockers...
June 19, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29915532/engineering-artificial-somatosensation-through-cortical-stimulation-in-humans
#9
Brian Lee, Daniel Kramer, Michelle Armenta Salas, Spencer Kellis, David Brown, Tatyana Dobreva, Christian Klaes, Christi Heck, Charles Liu, Richard A Andersen
Sensory feedback is a critical aspect of motor control rehabilitation following paralysis or amputation. Current human studies have demonstrated the ability to deliver some of this sensory information via brain-machine interfaces, although further testing is needed to understand the stimulation parameters effect on sensation. Here, we report a systematic evaluation of somatosensory restoration in humans, using cortical stimulation with subdural mini-electrocorticography (mini-ECoG) grids. Nine epilepsy patients undergoing implantation of cortical electrodes for seizure localization were also implanted with a subdural 64-channel mini-ECoG grid over the hand area of the primary somatosensory cortex (S1)...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29914028/deep-brain-stimulation-targeting-the-fornix-for-mild-alzheimer-dementia-the-advance-trial-a-two-year-follow-up-including-results-of-delayed-activation
#10
Jeannie-Marie S Leoutsakos, Haijuan Yan, William S Anderson, Wael F Asaad, Gordon Baltuch, Anna Burke, M Mallar Chakravarty, Kristen E Drake, Kelly D Foote, Lisa Fosdick, Peter Giacobbe, Zoltan Mari, Mary Pat McAndrews, Cynthia A Munro, Esther S Oh, Michael S Okun, Jo Cara Pendergrass, Francisco A Ponce, Paul B Rosenberg, Marwan N Sabbagh, Stephen Salloway, David F Tang-Wai, Steven D Targum, David Wolk, Andres M Lozano, Gwenn S Smith, Constantine G Lyketsos
BACKGROUND: Given recent challenges in developing new treatments for Alzheimer dementia (AD), it is vital to explore alternate treatment targets, such as neuromodulation for circuit dysfunction. We previously reported an exploratory Phase IIb double-blind trial of deep brain stimulation targeting the fornix (DBS-f) in mild AD (the ADvance trial). We reported safety but no clinical benefits of DBS-f versus the delayed-on (sham) treatment in 42 participants after one year. However, secondary post hoc analyses of the one-year data suggested a possible DBS-f benefit for participants≥65 years...
June 9, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29913805/translational-aspects-of-rectal-evoked-potentials-a-comparative-study-in-rats-and-humans
#11
Thomas Dahl Nissen, Carina Graversen, Steven Coen, Leif Hultin, Qasim Aziz, Jens Lykkesfeldt, Asbjørn Mohr Drewes, Christina Brock
Background In recent years only few novel drugs targeting visceral pain have been developed. This lack of success may be explained by animal models having poor predictive value. To increase the success of translating results from animals to humans there is a demand for comparable test models. The aim was to establish a comparable and reliable translational model to evoke mechanical rectal pain in rats and humans. Methods Mechanical rectal rapid balloon distension was done on two different days in 12 rats (separated by 24...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913360/spinal-cord-stimulation-in-the-treatment-of-complex-regional-pain-syndrome-type-1-is-trial-truly-required
#12
Erica Garbin Risson, Ana Paula Serpa, Jéssica Jacques Berger, Renata Fabiola Heil Koerbel, Andrei Koerbel
OBJECTIVE: Spinal cord stimulation has been proven highly effective in the treatment of Complex Regional Pain Syndrome (CRPS). The definitive implantation of a neurostimulator is usually preceded by a therapeutic test (trial), which has the purpose of identifying whether the patient would respond positively to neuromodulation or not. The present study aims to analyze the surgical results of spinal cord stimulation in type 1 CRPS patients who have not undergone trial. PATIENTS AND METHODS: From January 2011 to August 2017, 160 patients underwent implantation of spinal cord neurostimulator...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29912821/cochlear-patency-after-translabyrinthine-vestibular-schwannoma-surgery
#13
Fiona C E Hill, Alasdair Grenness, Shannon Withers, Claire Iseli, Robert Briggs
OBJECTIVES: To determine the temporal occurrence of fluid signal changes on T2-weighted magnetic resonance imaging (T2MRI) that occur in the cochlear lumen after translabyrinthine surgery. STUDY DESIGN: Retrospective case control study. SETTING: Tertiary referral neurotology center. SUBJECTS AND METHODS: Seventy-one patients were identified who underwent translabyrinthine removal of a vestibular schwannoma between 2010 and 2014; of these 49 were included as they had postoperative T2 MRI at 6, 18, and 48 months available postsurgery...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29912820/hearing-preservation-outcomes-after-cochlear-implantation-depending-on-the-angle-of-insertion-indication-for-electric-or-electric-acoustic-stimulation
#14
Silke Helbig, Youssef Adel, Martin Leinung, Timo Stöver, Uwe Baumann, Tobias Weissgerber
OBJECTIVE: This study reviewed outcomes of hearing preservation (HP) surgery depending on the angle of insertion (AOI) in a cochlear implant (CI) patient population who used electric stimulation (ES) or combined electric-acoustic stimulation (EAS). STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral university hospital. PATIENTS: Ninety-one patients with different degrees of preoperative low-frequency residual hearing who underwent HP surgery with a free-fitting lateral-wall electrode array (MED-EL Flex) with lengths ranging from 20...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29912203/an-invasive-method-for-the-activation-of-the-mouse-dentate-gyrus-by-high-frequency-stimulation
#15
Zhe Zhao, Haitao Wu
Electrical high-frequency stimulation (HFS), using implanted electrodes targeting various brain regions, has been proven as an effective treatment for various neurological and psychiatric disorders. HFS in the deep region of the brain, also named deep-brain stimulation (DBS), is becoming increasingly important in clinical trials. Recent progress in the field of high-frequency DBS (HF-DBS) surgery has begun to spread the possibility of utilizing this invasive technique to other situations, such as treatment for major depression disorder (MDD), obsessive-compulsive disorder (OCD), and so on...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29910567/detection-of-biofilm-associated-implant-pathogens-in-cardiac-device-infections-high-sensitivity-of-sonication-fluid-culture-even-in-the-presence-of-antimicrobials
#16
Alessandra Oliva, Maria Teresa Mascellino, Bich Lien Nguyen, Massimiliano De Angelis, Alessia Cipolla, Annalisa Di Berardino, Antonio Ciccaglioni, Claudio Maria Mastroianni, Vincenzo Vullo
Introduction: Sonication showed more sensitivity than traditional culture in the diagnosis of device infections. Aims of the study were to assess the role of sonication in the microbiological diagnosis and management of cardiac device infections (CDIs), to evaluate the sensitivity of sonication in patients on antimicrobial therapy at the time of device removal, and to analyze biofilm formation of the isolated strains. Materials and Methods: A total of 90 devices (31 generators and 59 electrodes) collected from 31 patients with infection underwent sonication before culture...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29909807/selection-of-the-appropriate-cochlear-electrode-array-using-a-specifically-developed-research-software-application
#17
E H Stefanescu, S Motoi
OBJECTIVE: To evaluate the usefulness and reliability of a research software application for the estimation of an individual's cochlear duct length as a basis for electrode selection. METHODS: In this prospective cohort study, 21 consecutive patients (23 ears) implanted with a cochlear electrode were investigated. The study comprised 19 children (2 bilateral) and 2 adults. RESULTS: The measured 'A' distances (the largest distance from the round window to the contralateral wall) corresponded to cochlear duct lengths of 28...
June 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29909732/cognitive-outcomes-after-cochlear-implantation-in-older-adults-a-systematic-review
#18
Annes J Claes, Paul Van de Heyning, Annick Gilles, Vincent Van Rompaey, Griet Mertens
OBJECTIVES: To critically assess the current status of the literature on cognitive outcomes after cochlear implantation in older adults. METHODS: Studies were identified by searching MEDLINE (PubMed) and Cochrane Library, and checking reference lists of relevant articles. No restrictions were imposed regarding language, publication date, or publication status. Eligibility criteria were as follows: (1) the study sample included older adults aged 50 or over with severe to profound bilateral hearing loss, (2) the participants received a multi-electrode cochlear implant, and (3) a cognitive test was performed before and after implantation...
June 18, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29907526/invasive-eeg-electrodes-in-presurgical-evaluation-of-epilepsies-systematic-analysis-of-implantation-video-eeg-monitoring-and-explantation-related-complications-and-review-of-literature
#19
Laurent M Willems, Philipp S Reif, Andrea Spyrantis, Adriano Cattani, Thomas M Freiman, Volker Seifert, Marlies Wagner, Se-Jong You, Susanne Schubert-Bast, Sebastian Bauer, Karl Martin Klein, Felix Rosenow, Adam Strzelczyk
INTRODUCTION: Stereoelectroencephalography (sEEG) is a diagnostic procedure for patients with refractory focal epilepsies that is performed to localize and define the epileptogenic zone. In contrast to grid electrodes, sEEG electrodes are implanted using minimal invasive operation techniques without large craniotomies. Previous studies provided good evidence that sEEG implantation is a safe and effective procedure; however, complications in asymptomatic patients after explantation may be underreported...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29905525/ultrasound-guided-spinal-stereotactic-system-for-intraspinal-implants
#20
Amirali Toossi, Dirk G Everaert, Peter Seres, Jacob L Jaremko, Kevin Robinson, C Chris Kao, Peter E Konrad, Vivian K Mushahwar
OBJECTIVE The overall goal of this study was to develop an image-guided spinal stereotactic setup for intraoperative intraspinal microstimulation (ISMS). System requirements were as follows: 1) ability to place implants in various segments of the spinal cord, targeting the gray matter with a < 0.5-mm error; 2) modularity; and 3) compatibility with standard surgical tools. METHODS A spine-mounted stereotactic system was developed, optimized, and tested in pigs. The system consists of a platform supporting a micromanipulator with 6 degrees of freedom...
June 15, 2018: Journal of Neurosurgery. Spine
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