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https://www.readbyqxmd.com/read/29679457/burst-spinal-cord-stimulation-in-peripherally-injured-chronic-neuropathic-rats-a-delayed-effect
#1
Koen P V Meuwissen, Jianwen Wendy Gu, Tianhe C Zhang, Elbert A J Joosten
OBJECTIVE: Two well-known spinal cord stimulation (SCS) paradigms, Conventional (Con) and Burst-SCS, are hypothesized to exert their anti-nociceptive effects through different stimulation-induced mechanisms. We studied the course of the behavioral anti-nociceptive effect during 60 minutes of SCS and 30 minutes post SCS, in a rat model of chronic neuropathic pain. MATERIAL AND METHODS: Animals received a unilateral partial sciatic nerve ligation, after which they were implanted with quadripolar electrodes into the epidural space at vertebral level T13 (n=43 rats)...
April 20, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29676713/-deep-brain-stimulation-for-psychiatric-disorders
#2
M Figee, P R Schuurman, D Denys
- Deep brain stimulation (DBS) corrects pathological activity of neuropsychiatric brain networks with high frequency current via implanted brain electrodes.- DBS is an effective and safe treatment for therapy-refractory obsessive-compulsive disorder and potentially also for therapy-refractory major depressive disorder.- Experimental psychiatric indications for DBS are Tourette syndrome, addiction, anorexia nervosa, post-traumatic stress disorder, autism and schizophrenia.- DBS influences brain networks that are relevant for a variety of psychiatric symptoms...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676681/frameless-robot-assisted-stereoelectroencephalography-in-children-technical-aspects-and-comparison-with-talairach-frame-technique
#3
Taylor J Abel, René Varela Osorio, Ricardo Amorim-Leite, Francois Mathieu, Philippe Kahane, Lorella Minotti, Dominique Hoffmann, Stephan Chabardes
OBJECTIVE Robot-assisted stereoelectroencephalography (SEEG) is gaining popularity as a technique for localization of the epileptogenic zone (EZ) in children with pharmacoresistant epilepsy. Here, the authors describe their frameless robot-assisted SEEG technique and report preliminary outcomes and relative complications in children as compared to results with the Talairach frame-based SEEG technique. METHODS The authors retrospectively analyzed the results of 19 robot-assisted SEEG electrode implantations in 17 consecutive children (age < 17 years) with pharmacoresistant epilepsy, and compared these results to 19 preceding SEEG electrode implantations in 18 children who underwent the traditional Talairach frame-based SEEG electrode implantation...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29675920/long-term-feasibility-and-biocompatibility-of-directly-microsurgically-implanted-intrafascicular-electrodes-in-free-roaming-rabbits
#4
Gehua Zhen, Huanwen Chen, Shin-Yi Tsai, Jian Zhang, Tongyi Chen, Xiaofeng Jia
Novel neural interfaces capable of reliably capturing electrical signals are crucial for the development of prostheses. Longitudinal intrafascicular electrodes (LIFEs) have been proposed as a promising technology, and their feasibility and biocompatibility need to be investigated for long-term implantation. In this study, custom-designed 95%Pt-5%Ir intrafascicular electrodes were implanted into the sciatic nerves of 14 rabbits using our novel direct microsurgical technique. The biocompatibility and their ability to record electrophysiological signals were serially investigated up to 9 months after implantation...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29667119/a-novel-neural-electrode-with-micro-motion-attenuation-capability-based-on-compliant-mechanisms-physical-design-concepts-and-evaluations
#5
Wenguang Zhang, Jiaqi Tang, Zhengwei Li, Yakun Ma
In order to solve the problem of the short lifespan of the neural electrode caused by micro motion, this study designed a novel neural electrode based on lumped compliance compliant mechanism to control different modes of micro-motion in a more effective way. According to the mathematical modeling of the novel neural electrode, the equivalent bending stiffness and equivalent tensile (compression) stiffness were calculated. The results of the finite element analysis based on the mathematical modeling revealed that the novel neural electrode showed excellent micro-motion-attenuation capability...
April 18, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29666407/an-implantable-peripheral-nerve-recording-and-stimulation-system-for-experiments-on-freely-moving-animal-subjects
#6
Byunghun Lee, Mukhesh K Koripalli, Yaoyao Jia, Joshua Acosta, M S E Sendi, Yoonsu Choi, Maysam Ghovanloo
A new study with rat sciatic nerve model for peripheral nerve interfacing is presented using a fully-implanted inductively-powered recording and stimulation system in a wirelessly-powered standard homecage that allows animal subjects move freely within the homecage. The Wireless Implantable Neural Recording and Stimulation (WINeRS) system offers 32-channel peripheral nerve recording and 4-channel current-controlled stimulation capabilities in a 3 × 1.5 × 0.5 cm3 package. A bi-directional data link is established by on-off keying pulse-position modulation (OOK-PPM) in near field for narrow-band downlink and 433 MHz OOK for wideband uplink...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665982/oscillatory-activity-and-cortical-coherence-of-the-nucleus-basalis-of-meynert-in-parkinson-s-disease-dementia
#7
Muhammad Nazmuddin, D L Marinus Oterdoom, J Marc C van Dijk, Jonathan C van Zijl, Anne K Kampman, Gea Drost, Teus van Laar, Martijn Beudel
BACKGROUND: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied. METHODS: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM...
March 28, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29664726/measurement-of-the-electrically-evoked-stapedial-reflex-response-with-wideband-acoustic-reflectance-measurement
#8
Jace Wolfe, Rene Gifford, Erin Schafer
BACKGROUND: The electrically evoked stapedial reflex threshold (ESRT) has been shown to be a good predictor of upper stimulation level for cochlear implant recipients. Previous research has shown that the ESRT may be recorded at lower stimulation levels and with a higher incidence of success with the use of higher frequency probe tones (e.g., 678 and 1000 Hz) relative to the use of the conventional 226-Hz probe tone. Research has also shown that the acoustic reflex may be recorded at lower stimulus levels with the use of wideband reflectance when compared to the acoustic reflex threshold recorded with a conventional acoustic immittance measurement...
April 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29664723/the-value-of-electrically-evoked-stapedius-reflex-in-determining-the-maximum-comfort-level-of-a-cochlear-implant
#9
Kelly Cristina Lira de Andrade, Lilian Ferreira Muniz, Pedro de Lemos Menezes, Silvio da Silva Caldas Neto, Aline Tenório Lins Carnaúba, Mariana de Carvalho Leal
BACKGROUND: One of the most important steps for good user performance with a cochlear implant (CI) is activation and programming, aimed at determining the dynamic range. In adults, current levels are determined by psychophysical measures. In babies, small children, or individuals with multiple disorders, this procedure requires techniques that may provide inconsistent responses because of auditory inexperience or the age of the child, making it a very difficult process that demands the collaboration of both the patient and the family...
April 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29658939/simultaneous-recordings-of-cortical-local-field-potentials-electrocardiogram-electromyogram-and-breathing-rhythm-from-a-freely-moving-rat
#10
Yu Shikano, Takuya Sasaki, Yuji Ikegaya
Monitoring the physiological dynamics of the brain and peripheral tissues is necessary for addressing a number of questions about how the brain controls body functions and internal organ rhythms when animals are exposed to emotional challenges and changes in their living environments. In general experiments, signals from different organs, such as the brain and the heart, are recorded by independent recording systems that require multiple recording devices and different procedures for processing the data files...
April 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29658864/right-ventricular-perforation-by-a-defibrillator-lead-migrating-to-the-left-breast
#11
Jerneja Tasic, Rok Zbacnik, Igor Zupan, Jus Ksela
Cardiac perforation after an ICD implantation is a rare complication, with a reported incidence between 0.6-5.2%. Its manifestation might be acute, subacute, or delayed, with an acute perforation occurring within the first 24 hours after implantation, frequently accompanied by severe clinical signs, while subacute and delayed perforations have a more benign progression. Here, we report a case of a 69-year old patient with an acute right ventricular perforation by a defibrillator lead migrating all the way through the pericardium and thoracic wall into the left breast, with an unusually mild and benign clinical course, delaying prompt diagnosis and postponing subsequent surgical treatment...
March 5, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29658089/electrophysiological-properties-of-rat-vestibular-labyrinth-and-their-effect-on-parameters-of-transmitted-voltage-pulses
#12
V P Demkin, V V Udut, P P Shchetinin, M V Svetlik, S V Mel'nichuk, A P Shchetinina, M O Pleshkov, D N Starkov, O V Demkin, H Kingma
We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit...
April 16, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29652892/the-effects-of-electrical-field-spatial-spread-and-some-cognitive-factors-on-speech-in-noise-performance-of-individual-cochlear-implant-users-a-computer-model-study
#13
Tim Jürgens, Volker Hohmann, Andreas Büchner, Waldo Nogueira
The relation of the individual speech-in-noise performance differences in cochlear implant (CI) users to underlying physiological factors is currently poorly understood. This study approached this research question by a step-wise individualization of a computer model of speech intelligibility mimicking the details of CI signal processing and some details of the physiology present in CI users. Two factors, the electrical field spatial spread and internal noise (as a coarse model of the individual cognitive performance) were incorporated...
2018: PloS One
https://www.readbyqxmd.com/read/29652234/computer-assisted-planning-for-the-insertion-of-stereoelectroencephalography-electrodes-for-the-investigation-of-drug-resistant-focal-epilepsy-an-external-validation-study
#14
Vejay N Vakharia, Rachel Sparks, Roman Rodionov, Sjoerd B Vos, Christian Dorfer, Jonathan Miller, Daniel Nilsson, Martin Tisdall, Stefan Wolfsberger, Andrew W McEvoy, Anna Miserocchi, Gavin P Winston, Aidan G O'Keeffe, Sebastien Ourselin, John S Duncan
OBJECTIVE One-third of cases of focal epilepsy are drug refractory, and surgery might provide a cure. Seizure-free outcome after surgery depends on the correct identification and resection of the epileptogenic zone. In patients with no visible abnormality on MRI, or in cases in which presurgical evaluation yields discordant data, invasive stereoelectroencephalography (SEEG) recordings might be necessary. SEEG is a procedure in which multiple electrodes are placed stereotactically in key targets within the brain to record interictal and ictal electrophysiological activity...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651998/high-resolution-local-field-potentials-measured-with-deep-brain-stimulation-arrays
#15
Simeng Zhang, Allison T Connolly, Lauren Madden, Jerrold L Vitek, Matthew D Johnson
Local field potential (LFP) recordings along a deep brain stimulation (DBS) lead can provide useful feedback for titrating DBS therapy. However, conventional DBS leads with four cylindrical macroelectrodes likely undersample the spatial distribution of sinks and sources in a given brain region. In this study, we investigated the spectral power and spatial feature sizes of LFP activity in non-human primate subthalamic nucleus and globus pallidus using chronically implanted 32-channel directional DBS arrays.&#13; &#13; Approach: Subthalamic nucleus and globus pallidus LFP signals were recorded from directional DBS arrays in the resting state and during a reach-and-retrieval task in two non-human primates in naïve and parkinsonian conditions...
April 13, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29649894/use-of-neural-response-telemetry-for-pediatric-cochlear-implants-current-practice
#16
Galit Almosnino, Samantha Anne, Seth R Schwartz
OBJECTIVES: Evaluate usage trends of neural response telemetry (NRT) in cochlear implant centers across the nation and assess reported benefits of intraoperative NRT for pediatric cochlear implant recipients. STUDY DESIGN: Survey. STUDY PARTICIPANTS: All US cochlear implant centers (n = 110). METHODS: A 15-question multiple-choice survey was distributed electronically to all centers. The survey captured demographic information of all centers, practice patterns surrounding the use of NRT, and the extent to which intraoperative NRT is of benefit...
April 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29649048/improved-speech-perception-in-cochlear-implant-users-with-interleaved-high-rate-pulse-trains
#17
Christina L Runge, Fang Du, Yi Hu
OBJECTIVE: Electrical stimulation with a cochlear implant (CI) elicits abnormally high neural synchrony, which poses significant challenges for speech perception. Previous investigations showed that constant-amplitude high-rate pulse trains (HRPs) desynchronize neural responses and improve stimulus encoding. The study objective was to investigate the effects of HRP on speech perception in adult CI users. STUDY DESIGN: Prospective, within-subject design. SETTING: Tertiary CI center...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29644947/intracranial-electroencephalographic-monitoring-from-subdural-to-depth-electrodes
#18
Holger Joswig, David A Steven, Andrew G Parrent, Keith W MacDougall, Seyed M Mirsattari, Richard S McLachlan, David C Diosy, Jorge G Burneo
At the London Health Sciences Centre Epilepsy Program, stereotactically implanted depth electrodes have largely replaced subdural electrodes in the presurgical investigation of patients with drug-resistant epilepsy over the past 4 years. The rationale for this paradigm shift was more experience with, and improved surgical techniques for, stereoelectroencephalography, a possible lower-risk profile for depth electrodes, better patient tolerability, shorter operative time, as well as increased recognition of potential surgical targets that are not accessible to subdural electrodes...
April 12, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29644280/atypical-cardioversion-in-unstable-arrhythmia-caused-by-clavicle-surgery
#19
Stefan Bushuven, Ronny Langenhan
We report on a 54-year old male with traumatic brain injury, flail chest and floating shoulder undergoing intramedullary stabilization of a midshaft clavicle fracture in beach chair position. Intraoperatively the patient developed instable atrial fibrillation triggered by implantation of intramedullary nail. Secondary this case shows feasibility of cardioversion in latero-lateral electrode-position due to inaccessible standard positions and patient fixation between the operation table and the X-ray apparatus...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29626167/intracranial-electrophysiology-reveals-reproducible-intrinsic-functional-connectivity-within-human-brain-networks
#20
Aaron Kucyi, Jessica Schrouff, Stephan Bickel, Brett L Foster, James M Shine, Josef Parvizi
Evidence for intrinsic functional connectivity (FC) within the human brain is largely from neuroimaging studies of hemodynamic activity. Data are lacking from anatomically precise electrophysiological recordings in the most widely studied nodes of human brain networks. Here we used a combination of fMRI and electrocorticography (ECoG) in five human neurosurgical patients with electrodes in the canonical "default" (medial prefrontal and posteromedial cortex), "dorsal attention" (frontal eye fields and superior parietal lobule) and "frontoparietal control" (inferior parietal lobule and dorsolateral prefrontal cortex) networks...
April 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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