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https://www.readbyqxmd.com/read/29205030/crack-enhanced-microfluidic-stretchable-e-skin-sensor
#1
Dong Hae Ho, Ryun Geun Song, Qijun Sun, Won-Hyeong Park, So Young Kim, Changhyun Pang, Do Hwan Kim, Sang-Youn Kim, Jinkee Lee, Jeong Ho Cho
We reported the development of a transparent stretchable crack-enhanced microfluidic capacitive sensor array for use in E-skin applications. The microfluidic sensor was fabricated through a simple lamination process involving two silver nanowire (AgNW)-embedded rubbery microfluidic channels arranged in a crisscross fashion. The sensing performance was optimized by testing a variety of sensing liquids injected into the channels. External mechanical stimuli applied to the sensor induced the liquid to penetrate the deformed micro cracks on the rubber channel surface...
December 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29197747/soft-chitosan-microbeads-scaffold-for-3d-functional-neuronal-networks
#2
Maria Teresa Tedesco, Donatella Di Lisa, Paolo Massobrio, Nicolò Colistra, Mattia Pesce, Tiziano Catelani, Elena Dellacasa, Roberto Raiteri, Sergio Martinoia, Laura Pastorino
The availability of 3D biomimetic in vitro neuronal networks of mammalian neurons represents a pivotal step for the development of brain-on-a-chip experimental models to study neuronal (dys)functions and particularly neuronal connectivity. The use of hydrogel-based scaffolds for 3D cell cultures has been extensively studied in the last years. However, limited work on biomimetic 3D neuronal cultures has been carried out to date. In this respect, here we investigated the use of a widely popular polysaccharide, chitosan (CHI), for the fabrication of a microbead based 3D scaffold to be coupled to primary neuronal cells...
November 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/29182911/electrode-based-ac-electrokinetics-of-proteins-a-mini-review
#3
REVIEW
Eva-Maria Laux, Frank F Bier, Ralph Hölzel
Employing electric phenomena for the spatial manipulation of bioparticles from whole cells down to dissolved molecules has become a useful tool in biotechnology and analytics. AC electrokinetic effects like dielectrophoresis and AC electroosmosis are increasingly used to concentrate, separate and immobilize DNA and proteins. With the advance of photolithographical micro- and nanofabrication methods, novel or improved bioanalytical applications benefit from concentrating analytes, signal enhancement and locally controlled immobilization by AC electrokinetic effects...
November 23, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29160929/anatomical-variations-of-the-human-cochlea-determined-from-micro-ct-and-high-resolution-ct-imaging-and-reconstruction
#4
Jie Tang, Xianglong Tang, Zhenhua Li, YiKang Liu, SongHua Tan, Heng Li, RongDan Ke, Zhi Wang, Li Gong, AnZhou Tang
Understanding the anatomical variations in the human cochlea are important for cochlear implants. This study examined these variations using a reconstructed fusion model of the skull and temporal bone. The 3D digital model of the temporal bone was reconstructed from multiple axial micro-CT scans of temporal bone and high resolution CT (HRCT) of the skull from 15 cadavers. A skull model was reconstructed and merged with the reconstructed temporal bone. The 3D relationship between the cochlea and the skull's mid-sagittal plane was analyzed...
November 21, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29133859/conformal-transistor-arrays-based-on-solution-processed-organic-crystals
#5
Xiaoli Zhao, Bing Zhang, Qingxin Tang, Xueyan Ding, Shuya Wang, Yuying Zhou, Yanhong Tong, Yichun Liu
Conformal transistor array based on solution-processed organic crystals, which can provide sensory and scanning features for monitoring, biofeedback, and tracking of physiological function, presents one of the most promising technologies for future large-scale low-cost wearable and implantable electronics. However, it is still a huge challenge for the integration of solution-processed organic crystals into conformal FETs owing to a generally existing swelling phenomenon of the elastic materials and the lack of the corresponding device fabrication technology...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133846/large-scale-matching-of-function-to-the-genetic-identity-of-retinal-ganglion-cells
#6
Filippo Pisano, Erin Zampaglione, Niall McAlinden, Jennifer Roebber, Martin D Dawson, Keith Mathieson, Alexander Sher
Understanding the role of neurons in encoding and transmitting information is a major goal in neuroscience. This requires insight on the data-rich neuronal spiking patterns combined, ideally, with morphology and genetic identity. Electrophysiologists have long experienced the trade-offs between anatomically-accurate single-cell recording techniques and high-density multi-cellular recording methods with poor anatomical correlations. In this study, we present a novel technique that combines large-scale micro-electrode array recordings with genetic identification and the anatomical location of the retinal ganglion cell soma...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29106427/micro-nanoelectrochemical-probe-and-chip-devices-for-evaluation-of-three-dimensional-cultured-cells
#7
Kosuke Ino, Mustafa Şen, Hitoshi Shiku, Tomokazu Matsue
Herein, we present an overview of recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells. First, we discuss probe devices: a general outline, evaluation of O2 consumption, enzyme-modified electrodes, evaluation of endogenous enzyme activity, and the collection of cell components from cell aggregates are discussed. The next section is focused on integrated chip devices: a general outline, electrode array devices, smart electrode array devices, droplet detection of 3D cultured cells, cell manipulation using dielectrophoresis (DEP), and electrodeposited hydrogels used for fabrication of 3D cultured cells on chip devices are discussed...
November 6, 2017: Analyst
https://www.readbyqxmd.com/read/29105715/vertically-stacked-nanocellulose-tactile-sensor
#8
Minhyun Jung, Kyungkwan Kim, Bumjin Kim, Kwang-Jae Lee, Jae-Wook Kang, Sanghun Jeon
Paper-based electronic devices are attracting considerable attention, because the paper platform has unique attributes such as flexibility and eco-friendliness. Here we report on what is claimed to be the firstly fully integrated vertically-stacked nanocellulose-based tactile sensor, which is capable of simultaneously sensing temperature and pressure. The pressure and temperature sensors are operated using different principles and are stacked vertically, thereby minimizing the interference effect. For the pressure sensor, which utilizes the piezoresistance principle under pressure, the conducting electrode was inkjet printed on the TEMPO-oxidized-nanocellulose patterned with micro-sized pyramids, and the counter electrode was placed on the nanocellulose film...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29079771/ultrasensitive-gold-micro-structured-electrodes-enabling-the-detection-of-extra-cellular-long-lasting-potentials-in-astrocytes-populations
#9
Ana L G Mestre, Mónica Cerquido, Pedro M C Inácio, Sanaz Asgarifar, Ana S Lourenço, Maria L S Cristiano, Paulo Aguiar, Maria C R Medeiros, Inês M Araújo, João Ventura, Henrique L Gomes
Ultra-sensitive electrodes for extracellular recordings were fabricated and electrically characterized. A signal detection limit defined by a noise level of 0.3-0.4 μV for a bandwidth of 12.5 Hz was achieved. To obtain this high sensitivity, large area (4 mm(2)) electrodes were used. The electrode surface is also micro-structured with an array of gold mushroom-like shapes to further enhance the active area. In comparison with a flat gold surface, the micro-structured surface increases the capacitance of the electrode/electrolyte interface by 54%...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29075798/microelectrode-array-induced-neuronal-alignment-directs-neurite-outgrowth-analysis-using-a-fast-fourier-transform-fft
#10
Viktorija Radotić, Dries Braeken, Damir Kovačić
Many studies have shown that the topography of the substrate on which neurons are cultured can promote neuronal adhesion and guide neurite outgrowth in the same direction as the underlying topography. To investigate this effect, isotropic substrate-complementary metal-oxide-semiconductor (CMOS) chips were used as one example of microelectrode arrays (MEAs) for directing neurite growth of spiral ganglion neurons. Neurons were isolated from 5 to 7-day-old rat pups, cultured 1 day in vitro (DIV) and 4 DIV, and then fixed with 4% paraformaldehyde...
December 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29075204/human-cardiomyocyte-progenitor-cells-in-co-culture-with-rat-cardiomyocytes-form-a-pro-arrhythmic-substrate-evidence-for-two-different-arrhythmogenic-mechanisms
#11
Nicoline W Smit, Lucia Cócera Ortega, Anna M D Végh, Veronique M F Meijborg, Anke M Smits, Mischa Klerk, Anke J M Tijsen, Hanno L Tan, Marie-José H T Goumans, Gerard J J Boink, Ruben Coronel
Background: Cardiomyocyte progenitor cells (CMPCs) are a promising cell source for regenerative cell therapy to improve cardiac function after myocardial infarction. However, it is unknown whether undifferentiated CMPCs have arrhythmogenic risks. We investigate whether undifferentiated, regionally applied, human fetal CMPCs form a pro-arrhythmic substrate in co-culture with neonatal rat ventricular myocytes (NRVMs). Method: Unipolar extracellular electrograms, derived from micro-electrode arrays (8 × 8 electrodes) containing monolayers of NRVMs (control), or co-cultures of NRVMs and locally seeded CMPCs were used to determine conduction velocity and the incidence of tachy-arrhythmias...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29060684/specific-ca3-neurons-decode-neural-information-of-dentate-granule-cells-evoked-by-paired-pulse-stimulation-in-co-cultured-networks
#12
Daniele Poli, Thomas B DeMarse, Bruce C Wheeler, Gregory J Brewer
CA3 and dentate gyrus (DG) neurons are cultured in two-chamber devices on multi-electrode arrays (MEAs) and connected via micro-tunnels. In order to evoke time-locked activity, paired-pulse stimulation is applied to 22 different sites and repeated 25 times in each well in 5 MEA co-cultures and results compared to CA3-CA3 and DG-DG networks homologous controls. In these hippocampal sub-regions, we focus on the mechanisms underpinning a network's ability to decode the identity of site specific stimulation from analysis of evoked network responses using a support vector machine classifier...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28979189/uncorrelated-neural-firing-in-mouse-visual-cortex-during-spontaneous-retinal-waves
#13
Matthew T Colonnese, Jing Shen, Yasunobu Murata
Synchronous firing among the elements of forming circuits is critical for stabilization of synapses. Understanding the nature of these local network interactions during development can inform models of circuit formation. Within cortex, spontaneous activity changes throughout development. Unlike the adult, early spontaneous activity occurs in discontinuous population bursts separated by long silent periods, suggesting a high degree of local synchrony. However, whether the micro-patterning of activity within early bursts is unique to this early age and specifically tuned for early development is poorly understood, particularly within the column...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28976321/droplet-size-aware-and-error-correcting-sample-preparation-using-micro-electrode-dot-array-digital-microfluidic-biochips
#14
Zipeng Li, Kelvin Yi-Tse Lai, Krishnendu Chakrabarty, Tsung-Yi Ho, Chen-Yi Lee
Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for on-chip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain two major problems associated with sample preparation on a conventional DMFB. First, only a (1:1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. Second, only a limited number of sensors can be integrated on a conventional DMFB; as a result, the latency for error detection during sample preparation is significant...
September 29, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28968384/a-theoretical-framework-for-analyzing-coupled-neuronal-networks-application-to-the-olfactory-system
#15
Andrea K Barreiro, Shree Hari Gautam, Woodrow L Shew, Cheng Ly
Determining how synaptic coupling within and between regions is modulated during sensory processing is an important topic in neuroscience. Electrophysiological recordings provide detailed information about neural spiking but have traditionally been confined to a particular region or layer of cortex. Here we develop new theoretical methods to study interactions between and within two brain regions, based on experimental measurements of spiking activity simultaneously recorded from the two regions. By systematically comparing experimentally-obtained spiking statistics to (efficiently computed) model spike rate statistics, we identify regions in model parameter space that are consistent with the experimental data...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28966573/a-chronically-implantable-bidirectional-neural-interface-for-non-human-primates
#16
Misako Komatsu, Eriko Sugano, Hiroshi Tomita, Naotaka Fujii
Optogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. However, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and monitoring with minimal brain trauma are required. We aimed to develop a chronically implantable device for photostimulation of the brain of non-human primates. We used a micro-light-emitting diode (LED) array with a flexible polyimide film. The array was combined with a whole-cortex electrocorticographic (ECoG) electrode array for simultaneous photostimulation and recording...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28953287/hierarchical-bilayered-hybrid-nanostructural-arrays-of-nico2o4-micro-urchins-and-nanowires-as-a-free-standing-electrode-with-high-loading-for-high-performance-lithium-ion-batteries
#17
Yu Wang, Pengcheng Liu, Kongjun Zhu, Jing Wang, Jinsong Liu
Fabrication of free -standing binary transition metal oxides, especially NiCo2O4, has attracted significant research interests since these metal oxides are promising candidates for free-standing anodes of lithium-ion batteries (LIBs). However, there remain some problems, especially low loading, for the existing NiCo2O4 anodes. To address the abovementioned issue, it will be a quite feasible solution to combine the advantages of both hierarchical micro/nano-structures and free-standing electrodes to fabricate a free-standing hierarchical micro/nano-structural NiCo2O4 electrode...
October 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28951350/estimating-cortical-column-sensory-networks-in-rodents-from-micro-electrocorticograph-%C3%AE-ecog-recordings
#18
Ricardo Pizarro, Tom Richner, Sarah Brodnick, Sanitta Thongpang, Justin Williams, Barry Van Veen
Micro-electrocorticograph (μECoG) arrays offer the flexibility to record local field potentials (LFPs) from the surface of the cortex, using high density electrodes that are sub-mm in diameter. Research to date has not provided conclusive evidence for the underlying signal generation of μECoG recorded LFPs, or if μECoG arrays can capture network activity from the cortex. We studied the pervading view of the LFP signal by exploring the spatial scale at which the LFP can be considered elemental. We investigated the underlying signal generation and ability to capture functional networks by implanting, μECoG arrays to record sensory-evoked potentials in four rats...
September 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/28917552/crispr-correction-of-the-prkag2-gene-mutation-in-the-patient-s-induced-pluripotent-stem-cell-derived-cardiomyocytes-eliminates-electrophysiological-and-structural-abnormalities
#19
Ronen Ben Jehuda, Binyamin Eisen, Yuval Shemer, Lucy N Mekies, Agnes Szantai, Irina Reiter, Huanhuan Cui, Kaomei Guan, Shiraz Haron-Khun, Dov Freimark, Silke R Sperling, Mihaela Gherghiceanu, Michael Arad, Ofer Binah
BACKGROUND: Mutations in the PRKAG2 gene encoding the γ-subunit of adenosine monophosphate kinase (AMPK) cause hypertrophic cardiomyopathy (HCM) and familial Wolff-Parkinson-White (WPW) syndrome. Patients carrying the R302Q mutation in PRKAG2 present with sinus bradycardia, escape rhythms, ventricular preexcitation, supraventricular tachycardia, and atrioventricular block. This mutation affects AMPK activity and increases glycogen storage in cardiomyocytes. The link between glycogen storage, WPW syndrome, HCM, and arrhythmias remains unknown...
September 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28888021/simultaneous-monitoring-of-single-cell-and-of-micro-organ-activity-by-pedot-pss-covered-multi-electrode-arrays
#20
Dimitrios A Koutsouras, Romain Perrier, Ariana Villarroel Marquez, Antoine Pirog, Eileen Pedraza, Eric Cloutet, Sylvie Renaud, Matthieu Raoux, George G Malliaras, Jochen Lang
Continuous and long-term monitoring of cellular and micro-organ activity is required for new insights into physiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technology and especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities of surrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell action potentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs), reflecting coupled cell activity and overall organ physiology...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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