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https://www.readbyqxmd.com/read/28227513/in-vitro-assessment-of-long-term-reliability-of-low-cost-%C3%AE-ecog-arrays
#1
Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Michael Trumpis, Jonathan Viventi, Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Michael Trumpis, Jonathan Viventi, Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Jonathan Viventi, Michael Trumpis
Micro-electrocorticographic (μECοG) electrode arrays provide a minimally invasive, high-resolution neural interface with broad cortical coverage. Previously, we fabricated μECoG arrays at a lower cost than commercially available devices using low-cost industrial processes [1], [2]. Here, we report the in vitro electrical performance of five μECoG designs undergoing an accelerated aging protocol. The impedance and yield of the μECoG arrays were tracked over time. The equivalent lifetime at 37°C depended on the manufacturer and material stack-up, and ranged between 30 and greater than 760 days (ongoing)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227145/towards-an-implantable-bio-sensor-platform-for-continuous-real-time-monitoring-of-anti-epileptic-drugs
#2
Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan, Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan, Mohamad Sawan, Abbas Hammoud, Dang K Nguyen
The need of continuous real-time monitoring device for in-vivo drug level detection has been widely articulated lately. Such monitoring could guide drug posology and timing of intake, detect low or high drug levels, in order to take adequate measures, and give clinicians a valuable window into patients' health and their response to therapeutics. This paper presents a novel implantable bio-sensor based on impedance measurement capable of continuously monitoring various antiepileptic drug levels. This portable point-of-care microsystem replaces large and stationary conventional macrosystems, and is a one of a kind system designed with an array of electrodes to monitor various anti-epileptic drugs rather than one drug...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227102/a-flexible-parylene-probe-for-in-vivo-recordings-from-multiple-subregions-of-the-rat-hippocampus
#3
Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song, Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song, Ellis Meng, Dong Song, Min-Chi Hsiao, Theodore W Berger, Ahuva Weltman, Kee Scholten, Huijing Xu
The hippocampus is crucial to the formation of long-term memory and declarative memory. It is divided into three sub-fields the CA1, the CA3 and the DG. To understand the neuronal circuitry within the hippocampus and to study the role of the hippocampus in memory function requires the collection of neural activities from multiple subregions of the hippocampus simultaneously. Micro-wire electrode arrays are commonly used as an interface with neural systems. However, recording from multiple deep brain regions with curved anatomical structures such as the thin cell body layers of the hippocampus requires the micro-wires to be arranged into a highly accurate, complex layout that is difficult to fabricated manually...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227101/high-density-penetrating-electrode-arrays-for-autonomic-nerves
#4
John Burns, Yee-Hsee Hsieh, Andrew Mueller, Juliette Chevallier, T S Sriram, Stephen J Lewis, Daniel Chew, Anil Achyuta, Jason Fiering, John Burns, Yee-Hsee Hsieh, Andrew Mueller, Juliette Chevallier, T S Sriram, Stephen J Lewis, Daniel Chew, Anil Achyuta, Jason Fiering, Daniel Chew, Yee-Hsee Hsieh, Andrew Mueller, Jason Fiering, T S Sriram, Juliette Chevallier, Stephen J Lewis, Anil Achyuta
Electrode arrays for recording and stimulation in the central nervous system have enabled numerous advances in basic science and therapeutic strategies. In particular, micro-fabricated arrays with precision size and spacing offer the benefit of accessing single neurons and permit mapping of neuronal function. Similar advances are envisioned toward understanding the autonomic nervous system and developing therapies based on its modulation, but appropriate electrode arrays are lacking. Here, we present for the first time, a multi-channel electrode array suitable for penetration of peripheral nerves having diameters as small as 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227099/a-large-scale-detailed-neuronal-model-of-electrical-stimulation-of-the-dentate-gyrus-and-perforant-path-as-a-platform-for-electrode-design-and-optimization
#5
Clayton S Bingham, Kyle Loizos, Gene Yu, Andrew Gilbert, Jean-Marie Bouteiller, Dong Song, Gianluca Lazzi, Theodore W Berger, Clayton S Bingham, Kyle Loizos, Gene Yu, Andrew Gilbert, Jean-Marie Bouteiller, Dong Song, Gianluca Lazzi, Theodore W Berger, Kyle Loizos, Gene Yu, Theodore W Berger, Gianluca Lazzi, Jean-Marie Bouteiller, Clayton S Bingham, Dong Song, Andrew Gilbert
Owing to the dramatic rise in treatment of neurological disorders with electrical micro-stimulation it has become apparent that the major technological limitation in deploying effective devices lies in the process of designing efficient, safe, and outcome specific electrode arrays. The time-consuming and low-fidelity nature of gathering test data using experimental means and the immense control and flexibility of computational models, has prompted us and others to build models of electrical stimulation of neural networks that can be simulated in a computer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226797/thin-film-high-density-micro-electrocorticographic-decoding-of-a-human-cortical-gyrus
#6
Leah Muller, Sarah Felix, Kedar G Shah, Kye Lee, Satinderpall Pannu, Edward F Chang, Leah Muller, Sarah Felix, Kedar G Shah, Kye Lee, Satinderpall Pannu, Edward F Chang, Satinderpall Pannu, Sarah Felix, Leah Muller, Kedar G Shah, Kye Lee, Edward F Chang
High-density electrocorticography (ECoG) arrays are promising interfaces for high-resolution neural recording from the cortical surface. Commercial options for high-density arrays are limited, and historically tradeoffs must be made between spatial coverage and electrode density. However, thin-film technology is a promising alternative for generating electrode arrays capable of large area coverage and high channel count, with resolution on the order of cortical columns in the functional surface unit of a human gyrus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217772/dielectrowetting-manipulation-for-digital-microfluidics-creating-transporting-splitting-and-merging-of-droplets
#7
Hongyao Geng, Jian Feng, Lisa Marie Stabryla, Sung Kwon Cho
Generating, splitting, transporting, and merging droplets are fundamental and critical unit operations for digital (droplet-based) microfluidics. State-of-the-art digital microfluidics performs such operations commonly using electrowetting-on-dielectric (EWOD) in the typical configuration of two parallel channel plates. This paper presents such operations using dielectrowetting (derived from liquid dielectrophoresis), not EWOD, with an array of interdigitated electrodes. The major and unique feature is that the present droplet manipulations are effective for conductive (water with/without surfactant) and non-conductive (propylene carbonate) fluids...
February 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28192153/comparison-of-the-acute-inhibitory-effects-of-tetrodotoxin-ttx-in-rat-and-human-neuronal-networks-for-risk-assessment-purposes
#8
Emma E J Kasteel, Remco H S Westerink
Tetrodotoxin (TTX) is an extremely toxic marine neurotoxin. TTX inhibits voltage-gated sodium channels, resulting in a potentially lethal inhibition of neurotransmission. Despite numerous intoxications in Asia and Europe, limited (human) toxicological data are available for TTX. Additionally, the degree of interspecies differences for TTX is not well established, hampering the use of available (animal) data for human risk assessment and establishing regulatory limits for TTX concentrations in (shell)fish. We therefore used micro-electrode array (MEA) recordings as an integrated measure of neurotransmission to demonstrate that TTX inhibits neuronal electrical activity in both primary rat cortical cultures and human-induced pluripotent stem cell (hIPSC)-derived iCell(®) neurons in co-culture with hIPSC-derived iCell(®) astrocytes, with IC50 values of 7 and 10nM, respectively...
February 10, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28186204/nitrogen-doped-amorphous-carbon-silicon-core-shell-structures-for-high-power-supercapacitor-electrodes
#9
S A Safiabadi Tali, S Soleimani-Amiri, Z Sanaee, S Mohajerzadeh
We report successful deposition of nitrogen-doped amorphous carbon films to realize high-power core-shell supercapacitor electrodes. A catalyst-free method is proposed to deposit large-area stable, highly conformal and highly conductive nitrogen-doped amorphous carbon (a-C:N) films by means of a direct-current plasma enhanced chemical vapor deposition technique (DC-PECVD). This approach exploits C2H2 and N2 gases as the sources of carbon and nitrogen constituents and can be applied to various micro and nanostructures...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164693/hexagonal-arrays-of-cylindrical-nickel-micro-structures-for-improved-oxygen-evolution-reaction
#10
Michael T Y Paul, Brenden B Yee, David R Bruce, Byron D Gates
Fuel cell systems are of interest for a wide range of applications, in part for their utility in power generation from non-fossil fuel sources. However, the generation of these alternative fuels, through electrochemical means, is a relatively inefficient process due to gas passivation of the electrode surfaces. Uniform micro-structured nickel surfaces were prepared by photolithographic techniques as a systematic approach to correlate surface morphologies to their performance in the electrochemically driven oxygen evolution reaction (OER) in alkaline media...
February 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28117798/rapid-neuronal-differentiation-of-induced-pluripotent-stem-cells-for-measuring-network-activity-on-micro-electrode-arrays
#11
Monica Frega, Sebastianus H C van Gestel, Katrin Linda, Jori van der Raadt, Jason Keller, Jon-Ruben Van Rhijn, Dirk Schubert, Cornelis A Albers, Nael Nadif Kasri
Neurons derived from human induced Pluripotent Stem Cells (hiPSCs) provide a promising new tool for studying neurological disorders. In the past decade, many protocols for differentiating hiPSCs into neurons have been developed. However, these protocols are often slow with high variability, low reproducibility, and low efficiency. In addition, the neurons obtained with these protocols are often immature and lack adequate functional activity both at the single-cell and network levels unless the neurons are cultured for several months...
January 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28102827/a-low-cost-scalable-current-sensing-digital-headstage-for-high-channel-count-%C3%AE-ecog
#12
Michael Trumpis, Michele Insanally, Jialin Zou, Ashraf Elsharif, Ali Ghomashchi, N Sertac Artan, Robert C Froemke, Jonathan Viventi
OBJECTIVE: High channel count electrode arrays allow for the monitoring of large-scale neural activity at high spatial resolution. Implantable arrays featuring many recording sites require compact, high bandwidth front-end electronics. In the present study, we investigated the use of a small, light weight, and low cost digital current-sensing integrated circuit for acquiring cortical surface signals from a 61-channel micro-electrocorticographic (μECoG) array. APPROACH: We recorded both acute and chronic μECoG signal from rat auditory cortex using our novel digital current-sensing headstage...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28076757/ipsc-derived-retina-transplants-improve-vision-in-rd1-end-stage-retinal-degeneration-mice
#13
Michiko Mandai, Momo Fujii, Tomoyo Hashiguchi, Genshiro A Sunagawa, Shinichiro Ito, Jianan Sun, Jun Kaneko, Junki Sho, Chikako Yamada, Masayo Takahashi
Recent success in functional recovery by photoreceptor precursor transplantation in dysfunctional retina has led to an increased interest in using embryonic stem cell (ESC) or induced pluripotent stem cell (iPSC)-derived retinal progenitors to treat retinal degeneration. However, cell-based therapies for end-stage degenerative retinas that have lost the outer nuclear layer (ONL) are still a big challenge. In the present study, by transplanting mouse iPSC-derived retinal tissue (miPSC retina) in the end-stage retinal-degeneration model (rd1), we visualized the direct contact between host bipolar cell terminals and the presynaptic terminal of graft photoreceptors by gene labeling, showed light-responsive behaviors in transplanted rd1 mice, and recorded responses from the host retina with transplants by ex vivo micro-electroretinography and ganglion cell recordings using a multiple-electrode array system...
January 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28045786/three-dimensional-force-profile-during-cochlear-implantation-depends-on-individual-geometry-and-insertion-trauma
#14
Ersin Avci, Tim Nauwelaers, Volkmar Hamacher, Andrej Kral
OBJECTIVES: To preserve the acoustic hearing, cochlear implantation has to be as atraumatic as possible. Therefore, understanding the impact of the cochlear geometry on insertion forces and intracochlear trauma might help to adapt and improve the electrode insertion and reduce the probability of intracochlear trauma. DESIGN: The study was conducted on 10 fresh-frozen human temporal bones. The inner ear was removed from the temporal bone. The bony capsule covering the scala vestibuli was removed and the dissected inner ear was mounted on the three-dimensional (3D) force measurement system (Agilent technologies, Nano UTM, Santa Clare, CA)...
December 27, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/28029625/comparison-of-classifier-architectures-for-online-neural-spike-sorting
#15
Maryam Saeed, Amir A Khan, Awais M Kamboh
High-density, intracranial recordings from micro-electrode arrays need to undergo Spike Sorting in order to associate the recorded neuronal spikes to particular neurons. This involves spike detection, feature extraction, and classification. To reduce the data transmission and power requirements, on-chip real-time processing is becoming very popular. However, high computational resources are required for classifiers in on-chip spike-sorters, making scalability a great challenge. In this review paper, we analyze several popular classifiers to propose five new hardware architectures using the off-chip training with on-chip classification approach...
December 19, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28026170/pattern-directed-ordering-of-spin-dewetted-liquid-crystal-micro-or-nanodroplets-as-pixelated-light-reflectors-and-locomotives
#16
Bolleddu Ravi, Snigdha Chakraborty, Mitradip Bhattacharjee, Shirsendu Mitra, Abir Ghosh, Partho Sarathi Gooh Pattader, Dipankar Bandyopadhyay
Chemical pattern directed spin-dewetting of a macroscopic droplet composed of a dilute organic solution of liquid crystal (LC) formed an ordered array of micro- and nanoscale LC droplets. Controlled evaporation of the spin-dewetted droplets through vacuum drying could further miniaturize the size to the level of ∼90 nm. The size, periodicity, and spacing of these mesoscale droplets could be tuned with the variations in the initial loading of LC in the organic solution, the strength of the centripetal force on the droplet, and the duration of the evaporation...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28008963/characterization-of-dorsal-root-ganglion-neurons-cultured-on-silicon-micro-pillar-substrates
#17
Tihana Repić, Katarina Madirazza, Ezgi Bektur, Damir Sapunar
Our study focuses on characterization of dorsal root ganglion (DRG) neurons cultured on silicon micro-pillar substrates (MPS) with the ultimate goal of designing micro-electrode arrays (MEAs) for successful electrophysiological recordings of DRG neurons. Adult and neonatal DRG neurons were cultured on MPS and glass coverslips for 7 days in vitro. DRG neuronal distribution and morphometric analysis, including neurite alignment and length, was performed on MPS areas with different pillar width and spacing. We showed that MPS provide an environment for growth of adult and neonatal DRG neurons as permissive as control glass surfaces...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27925199/dopamine-dependent-effects-on-basal-and-glutamate-stimulated-network-dynamics-in-cultured-hippocampal-neurons
#18
Yan Li, Xin Chen, Rhonda Dzakpasu, Katherine Conant
Oscillatory activity occurs in cortical and hippocampal networks with specific frequency ranges thought to be critical to working memory, attention, differentiation of neuronal precursors, and memory trace replay. Synchronized activity within relatively large neuronal populations is influenced by firing and bursting frequency within individual cells, and the latter is modulated by changes in intrinsic membrane excitability and synaptic transmission. Published work suggests that dopamine, a potent modulator of learning and memory, acts on dopamine receptor 1-like dopamine receptors to influence the phosphorylation and trafficking of glutamate receptor subunits, along with long-term potentiation of excitatory synaptic transmission in striatum and prefrontal cortex...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27905472/electrochemical-communication-with-the-inside-of-cells-using-micro-patterned-vertical-carbon-nanofibre-electrodes
#19
F J Rawson, M T Cole, J M Hicks, J W Aylott, W I Milne, C M Collins, S K Jackson, N J Silman, P M Mendes
With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particular, given the comparable sizes of nanomaterials and biomolecules, there exist plenty of opportunities to develop functional nanoprobes with biomolecules for highly sensitive and selective biosensing, shedding new light on cellular behaviour. Towards this aim, herein we interface cells with patterned nano-arrays of carbon nanofibers forming a nanosensor-cell construct...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900829/self-templating-synthesis-of-hollow-co3-o4-microtube-arrays-for-highly-efficient-water-electrolysis
#20
Yun Pei Zhu, Tian Yi Ma, Mietek Jaroniec, Shi Zhang Qiao
In spite of recent advances in the synthesis of hollow micro/nanostructures, the fabrication of three-dimensional electrodes on the basis of these structures remains a major challenge. Herein, we develop an electrochemical sacrificial-template strategy to fabricate hollow Co3 O4 microtube arrays with hierarchical porosity. The resultant unique structures and integrated electrode configurations impart enhanced mass transfer and electron mobility, ensuring high activity and stability in catalyzing oxygen and hydrogen evolution reactions...
November 30, 2016: Angewandte Chemie
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