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https://www.readbyqxmd.com/read/28333641/droplet-size-aware-high-level-synthesis-for-micro-electrode-dot-array-digital-microfluidic-biochips
#1
Zipeng Li, Kelvin Yi-Tse Lai, Po-Hsien Yu, Krishnendu Chakrabarty, Tsung-Yi Ho, Chen-Yi Lee
A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. In recent years, DMFBs based on a microelectrode-dot-array (MEDA) architecture have been demonstrated. However, due to the inherent differences between today's DMFBs and MEDA, existing synthesis solutions for biochemistry mapping cannot be utilized for MEDA biochips. We present the first synthesis approach that can be used for MEDA biochips. We first present a general analytical model for droplet velocity and validate it experimentally using a fabricated MEDA biochip...
March 21, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28333440/high-packing-density-unidirectional-arrays-of-vertically-aligned-graphene-with-enhanced-areal-capacitance-for-high-power-micro-supercapacitors
#2
Shuanghao Zheng, Zhilin Li, Zhong-Shuai Wu, Yanfeng Dong, Feng Zhou, Sen Wang, Qiang Fu, Chenglin Sun, Liwei Guo, Xinhe Bao
Interfacial integration of the shape-engineered electrode with strongly bonded current collector is the key for minimizing both ionic and electronic resistance, and then developing high-power supercapacitors. Herein, we demonstrated the construction of high-power micro-supercapacitors (VG-MSCs) based on high-density unidirectional arrays of vertically aligned graphene (VG) nanosheets, derived from thermally decomposed SiC substrate. The as-grown VG arrays showed a standing basal plane orientation grown on (0001(-)) SiC substrate, tailored thickness (3...
March 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28332478/addressed-immobilization-of-biofunctionalized-diatoms-on-electrodes-by-gold-electrodeposition
#3
S Leonardo, D Garibo, M Fernández-Tejedor, C K O'Sullivan, M Campàs
Diatoms are single cell microalgae with a silica shell (frustule), which possess a micro/nanoporous pattern of unparalleled diversity far beyond the possibilities of current micro- and nanofabrication techniques. To explore diatoms as natural three-dimensional nanostructured supports in sensing and biosensing devices, a simple, rapid and stable method to immobilize diatoms via gold electrodeposition is described. In this process, gold microstructures are formed, immobilizing diatoms by entrapment or crossing their nanopores...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28322793/temporal-relation-between-neural-activity-and-neurite-pruning-on-a-numerical-model-and-a-microchannel-device-with-micro-electrode-array
#4
Yohei Kondo, Yuichiro Yada, Tatsuya Haga, Yuzo Takayama, Takuya Isomura, Yasuhiko Jimbo, Osamu Fukayama, Takayuki Hoshino, Kunihiko Mabuchi
Synapse elimination and neurite pruning are essential processes for the formation of neuronal circuits. These regressive events depend on neural activity and occur in the early postnatal days known as the critical period, but what makes this temporal specificity is not well understood. One possibility is that the neural activities during the developmentally regulated shift of action of GABA inhibitory transmission lead to the critical period. Moreover, it has been reported that the shifting action of the inhibitory transmission on immature neurons overlaps with synapse elimination and neurite pruning and that increased inhibitory transmission by drug treatment could induce temporal shift of the critical period...
March 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28321182/sparse-and-specific-coding-during-information-transmission-between-co-cultured-dentate-gyrus-and-ca3-hippocampal-networks
#5
Daniele Poli, Srikanth Thiagarajan, Thomas B DeMarse, Bruce C Wheeler, Gregory J Brewer
To better understand encoding and decoding of stimulus information in two specific hippocampal sub-regions, we isolated and co-cultured rat primary dentate gyrus (DG) and CA3 neurons within a two-chamber device with axonal connectivity via micro-tunnels. We tested the hypothesis that, in these engineered networks, decoding performance of stimulus site information would be more accurate when stimuli and information flow occur in anatomically correct feed-forward DG to CA3 vs. CA3 back to DG. In particular, we characterized the neural code of these sub-regions by measuring sparseness and uniqueness of the responses evoked by specific paired-pulse stimuli...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28319373/morphology-controllable-synthesis-of-zn-co-mixed-sulfide-nanostructures-on-carbon-fiber-paper-towards-efficient-rechargeable-zinc-air-batteries-and-water-electrolysis
#6
Xiaoyu Wu, Xiaopeng Han, Xiaoya Ma, Wei Zhang, Yida Deng, Cheng Zhong, Wenbin Hu
It remains an ongoing challenge to develop cheap, highly active and stable electrocatalysts to promote the sluggish electrocatalytic oxygen evolution, oxygen reduction, and hydrogen evolution reactions for rechargeable metal-air batteries and water-splitting systems. In this work, we report the morphology-controllable synthesis of zinc cobalt mixed sulfide (Zn-Co-S) nanoarchitectures, including nanosheets, nanoplates, and nanoneedles, grown on conductive carbon fiber paper (CFP) and the micro-nanostructure dependent electrochemical efficacy for catalyzing hydrogen and oxygen in zinc-air batteries and water electrolysis...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28317836/microscale-symmetrical-electroporator-array-as-a-versatile-molecular-delivery-system
#7
Mengxing Ouyang, Winfield Hill, Jung Hyun Lee, Soojung Claire Hur
Successful developments of new therapeutic strategies often rely on the ability to deliver exogenous molecules into cytosol. We have developed a versatile on-chip vortex-assisted electroporation system, engineered to conduct sequential intracellular delivery of multiple molecules into various cell types at low voltage in a dosage-controlled manner. Micro-patterned planar electrodes permit substantial reduction in operational voltages and seamless integration with an existing microfluidic technology. Equipped with real-time process visualization functionality, the system enables on-chip optimization of electroporation parameters for cells with varying properties...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290133/the-effects-of-acute-gaba-treatment-on-the-functional-connectivity-and-network-topology-of-cortical-cultures
#8
Yao Han, Hong Li, Yiran Lang, Yuwei Zhao, Hongji Sun, Peng Zhang, Xuan Ma, Jiuqi Han, Qiyu Wang, Jin Zhou, Changyong Wang
γ-Aminobutyric acid (GABA) is an inhibitory transmitter, acting on receptor channels to reduce neuronal excitability in matured neural systems. However, electrophysiological responses of whole neuronal ensembles to the exposure to GABA are still unclear. We used micro-electrode arrays (MEAs) to study the effects of the increasing amount of GABA on functional network of cortical neural cultures. Then the recorded data were analyzed by the cross-covariance analysis and graph theory. Results showed that after the GABA treatment, the activity parameters of firing rate, bursting rate, bursting duration and network burst frequency in neural cultures decreased as expected...
March 13, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28287475/concentric-electrode-organic-electrochemical-transistors-case-study-for-selective-hydrazine-sensing
#9
Sébastien Pecqueur, Stéphane Lenfant, David Guérin, Fabien Alibart, Dominique Vuillaume
We report on hydrazine-sensing organic electrochemical transistors (OECTs) with a design consisting of concentric annular electrodes. The design engineering of these OECTs was motivated by the great potential of using OECT sensing arrays in fields such as bioelectronics. In this work, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-based OECTs have been studied as aqueous sensors that are specifically sensitive to the lethal hydrazine molecule. These amperometric sensors have many relevant features for the development of hydrazine sensors, such as a sensitivity down to 10(-5) M of hydrazine in water, an order of magnitude higher selectivity for hydrazine than for nine other water-soluble common analytes, the capability to entirely recover its base signal after water flushing, and a very low operation voltage...
March 11, 2017: Sensors
https://www.readbyqxmd.com/read/28269278/in-vitro-assessment-of-long-term-reliability-of-low-cost-%C3%AE-ecog-arrays
#10
Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Michael Trumpis, Jonathan Viventi
Micro-electrocorticographic (μECοG) electrode arrays provide a minimally invasive, high-resolution neural interface with broad cortical coverage. Previously, we fabricated μECoG arrays at a lower cost than commercially available devices using low-cost industrial processes [1], [2]. Here, we report the in vitro electrical performance of five μECoG designs undergoing an accelerated aging protocol. The impedance and yield of the μECoG arrays were tracked over time. The equivalent lifetime at 37°C depended on the manufacturer and material stack-up, and ranged between 30 and greater than 760 days (ongoing)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268939/towards-an-implantable-bio-sensor-platform-for-continuous-real-time-monitoring-of-anti-epileptic-drugs
#11
Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan
The need of continuous real-time monitoring device for in-vivo drug level detection has been widely articulated lately. Such monitoring could guide drug posology and timing of intake, detect low or high drug levels, in order to take adequate measures, and give clinicians a valuable window into patients' health and their response to therapeutics. This paper presents a novel implantable bio-sensor based on impedance measurement capable of continuously monitoring various antiepileptic drug levels. This portable point-of-care microsystem replaces large and stationary conventional macrosystems, and is a one of a kind system designed with an array of electrodes to monitor various anti-epileptic drugs rather than one drug...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268901/a-flexible-parylene-probe-for-in-vivo-recordings-from-multiple-subregions-of-the-rat-hippocampus
#12
Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song
The hippocampus is crucial to the formation of long-term memory and declarative memory. It is divided into three sub-fields the CA1, the CA3 and the DG. To understand the neuronal circuitry within the hippocampus and to study the role of the hippocampus in memory function requires the collection of neural activities from multiple subregions of the hippocampus simultaneously. Micro-wire electrode arrays are commonly used as an interface with neural systems. However, recording from multiple deep brain regions with curved anatomical structures such as the thin cell body layers of the hippocampus requires the micro-wires to be arranged into a highly accurate, complex layout that is difficult to fabricated manually...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268900/high-density-penetrating-electrode-arrays-for-autonomic-nerves
#13
John Burns, Yee-Hsee Hsieh, Andrew Mueller, Juliette Chevallier, T S Sriram, Stephen J Lewis, Daniel Chew, Anil Achyuta, Jason Fiering
Electrode arrays for recording and stimulation in the central nervous system have enabled numerous advances in basic science and therapeutic strategies. In particular, micro-fabricated arrays with precision size and spacing offer the benefit of accessing single neurons and permit mapping of neuronal function. Similar advances are envisioned toward understanding the autonomic nervous system and developing therapies based on its modulation, but appropriate electrode arrays are lacking. Here, we present for the first time, a multi-channel electrode array suitable for penetration of peripheral nerves having diameters as small as 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268898/a-large-scale-detailed-neuronal-model-of-electrical-stimulation-of-the-dentate-gyrus-and-perforant-path-as-a-platform-for-electrode-design-and-optimization
#14
Clayton S Bingham, Kyle Loizos, Gene Yu, Andrew Gilbert, Jean-Marie Bouteiller, Dong Song, Gianluca Lazzi, Theodore W Berger
Owing to the dramatic rise in treatment of neurological disorders with electrical micro-stimulation it has become apparent that the major technological limitation in deploying effective devices lies in the process of designing efficient, safe, and outcome specific electrode arrays. The time-consuming and low-fidelity nature of gathering test data using experimental means and the immense control and flexibility of computational models, has prompted us and others to build models of electrical stimulation of neural networks that can be simulated in a computer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268617/thin-film-high-density-micro-electrocorticographic-decoding-of-a-human-cortical-gyrus
#15
Leah Muller, Sarah Felix, Kedar G Shah, Kye Lee, Satinderpall Pannu, Edward F Chang
High-density electrocorticography (ECoG) arrays are promising interfaces for high-resolution neural recording from the cortical surface. Commercial options for high-density arrays are limited, and historically tradeoffs must be made between spatial coverage and electrode density. However, thin-film technology is a promising alternative for generating electrode arrays capable of large area coverage and high channel count, with resolution on the order of cortical columns in the functional surface unit of a human gyrus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260675/three-dimensional-porous-znco2o4-sheet-array-coated-with-ni-oh-2-for-high-performance-asymmetric-supercapacitor
#16
Yu Pan, Hong Gao, Mingyi Zhang, Lu Li, Guangning Wang, Xinyuan Shan
Hierarchical ZnCo2O4@Ni(OH)2 sheet composite structures on Ni foam were rationally designed and successfully synthesized. The ZnCo2O4 micro-sheets grown on Ni foam served as the skeleton to improve the electrical conductivity of redox active Ni(OH)2 materials, providing more electroactive sites for the faradaic reaction, and solidify the Ni(OH)2 materials onto Ni foam as a current collector. The electrode of ZnCo2O4@Ni(OH)2 showed an ultrahigh areal capacitance of 4.6F/cm(2) at a current density of 2mA/cm(2)...
February 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28256738/dielectrophoresis-assisted-loading-and-unloading-of-micro-wells-for-impedance-spectroscopy
#17
Amin Mansoorifar, Anil Koklu, Ahmet Can Sabuncu, Ali Beskok
Dielectric spectroscopy (DS) is a non-invasive, label-free, fast, and promising technique for measuring dielectric properties of biological cells in real time. We demonstrate a microchip that consists of electro-activated micro-well arrays for positive dielectrophoresis (pDEP) assisted cell capture, DS measurements, and negative dielectrophoresis (nDEP) driven cell unloading; thus, providing a high throughput cell analysis platform. To the best of our knowledge, this is the first microfluidic chip that combines electro-activated micro-wells and DS to analyze biological cells...
March 3, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28227513/in-vitro-assessment-of-long-term-reliability-of-low-cost-%C3%AE-ecog-arrays
#18
Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Michael Trumpis, Jonathan Viventi, Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Michael Trumpis, Jonathan Viventi, Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Jonathan Viventi, Michael Trumpis
Micro-electrocorticographic (μECοG) electrode arrays provide a minimally invasive, high-resolution neural interface with broad cortical coverage. Previously, we fabricated μECoG arrays at a lower cost than commercially available devices using low-cost industrial processes [1], [2]. Here, we report the in vitro electrical performance of five μECoG designs undergoing an accelerated aging protocol. The impedance and yield of the μECoG arrays were tracked over time. The equivalent lifetime at 37°C depended on the manufacturer and material stack-up, and ranged between 30 and greater than 760 days (ongoing)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227145/towards-an-implantable-bio-sensor-platform-for-continuous-real-time-monitoring-of-anti-epileptic-drugs
#19
Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan, Abbas Hammoud, Ahmad Chamseddine, Dang K Nguyen, Mohamad Sawan, Mohamad Sawan, Abbas Hammoud, Dang K Nguyen
The need of continuous real-time monitoring device for in-vivo drug level detection has been widely articulated lately. Such monitoring could guide drug posology and timing of intake, detect low or high drug levels, in order to take adequate measures, and give clinicians a valuable window into patients' health and their response to therapeutics. This paper presents a novel implantable bio-sensor based on impedance measurement capable of continuously monitoring various antiepileptic drug levels. This portable point-of-care microsystem replaces large and stationary conventional macrosystems, and is a one of a kind system designed with an array of electrodes to monitor various anti-epileptic drugs rather than one drug...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227102/a-flexible-parylene-probe-for-in-vivo-recordings-from-multiple-subregions-of-the-rat-hippocampus
#20
Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song, Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song, Ellis Meng, Dong Song, Min-Chi Hsiao, Theodore W Berger, Ahuva Weltman, Kee Scholten, Huijing Xu
The hippocampus is crucial to the formation of long-term memory and declarative memory. It is divided into three sub-fields the CA1, the CA3 and the DG. To understand the neuronal circuitry within the hippocampus and to study the role of the hippocampus in memory function requires the collection of neural activities from multiple subregions of the hippocampus simultaneously. Micro-wire electrode arrays are commonly used as an interface with neural systems. However, recording from multiple deep brain regions with curved anatomical structures such as the thin cell body layers of the hippocampus requires the micro-wires to be arranged into a highly accurate, complex layout that is difficult to fabricated manually...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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