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https://www.readbyqxmd.com/read/28695839/rapid-prototyping-of-flexible-intrafascicular-electrode-arrays-by-picosecond-laser-structuring
#1
Matthias Mueller, Natalia de la Oliva, Jaume Del Valle, Ignacio Delgado Martinez, Xavier Navarro, Thomas Stieglitz
Interfacing the peripheral nervous system can be performed with a large variety of electrode arrays. However, stimulating and recording a nerve while having a reasonable amount of channels limits the number of available systems. Translational research towards human clinical trial requires device safety and biocompatibility but would benefit from design flexibility in the development process to individualize probes. Approach. We selected established medical grade implant materials like precious metals and parylene C to develop a rapid prototyping process for novel intrafascicular electrode arrays using a picosecond laser structuring...
July 11, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28682595/scalable-fabrication-and-integration-of-graphene-microsupercapacitors-through-full-inkjet-printing
#2
Jiantong Li, Szymon Sollami Delekta, Panpan Zhang, Sheng Yang, Martin R Lohe, Xiaodong Zhuang, Xinliang Feng, Mikael Östling
A simple full-inkjet-printing technique is developed for the scalable fabrication of graphene-based microsupercapacitors (MSCs) on various substrates. High-performance graphene inks are formulated by integrating the electrochemically exfoliated graphene with a solvent exchange technique to reliably print graphene interdigitated electrodes with tunable geometry and thickness. Along with the printed polyelectrolyte, poly(4-styrenesulfonic acid), the fully printed graphene-based MSCs attain the highest areal capacitance of ∼0...
July 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28682082/nanoelectronic-coating-enabled-versatile-multi-functional-neural-probes
#3
Zhengtuo Zhao, Lan Luan, Xiaoling Wei, Hanlin Zhu, Xue Li, Shengqing Lin, Jennifer J Siegel, Raymond A Chitwood, Chong Xie
Brain function can be best studied by simultaneous measurements and modulation of the multifaceted signaling at the cellular scale. Extensive efforts have been made to develop multifunctional neural probes, typically involving highly specialized fabrication processes. Here, we report a novel multifunctional neural probe platform realized by applying ultra-thin nanoelectronic coating (NEC) on the surfaces of conventional microscale devices such as optical fibers and micropipettes. We fabricated the NECs by planar photolithography techniques using a substrate-less and multi-layer design, which host arrays of individually addressed electrodes with an overall thickness below 1 µm...
July 6, 2017: Nano Letters
https://www.readbyqxmd.com/read/28665426/a-paper-based-touch-sensor-with-an-embedded-micro-probe-array-fabricated-by-double-sided-laser-printing
#4
Gui-Wen Huang, Na Li, Hong-Mei Xiao, Qing-Ping Feng, Shao-Yun Fu
Touch sensor is one of the key components for human interfacing devices. However, although various touch sensors have been demonstrated, their sophisticated fabrication processes and complicated structures make them expensive and delicate, and thus they are not considered to be practical for wide application in daily life. Herein, we present a low-cost and scalable paper-based touch sensor suitable for practical applications. The sensor is based on the novel structure of embedded silver nanowire micro-probe arrays in a paper substrate, which exhibits high sensitivity to multiple touch inputs and compact structure with a total thickness of ca...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28618377/ring-and-peg-electrodes-for-minimally-invasive-and-long-term-sub-scalp-eeg-recordings
#5
Y B Benovitski, A Lai, C C McGowan, O Burns, V Maxim, D A X Nayagam, R Millard, G D Rathbone, M A le Chevoir, R A Williams, D B Grayden, C N May, M Murphy, W J D'Souza, M J Cook, C E Williams
OBJECTIVE: Minimally-invasive approaches are needed for long-term reliable Electroencephalography (EEG) recordings to assist with epilepsy diagnosis, investigation and more naturalistic monitoring. This study compared three methods for long-term implantation of sub-scalp EEG electrodes. METHODS: Three types of electrodes (disk, ring, and peg) were fabricated from biocompatible materials and implanted under the scalp in five ambulatory ewes for 3months. Disk electrodes were inserted into sub-pericranial pockets...
June 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28606117/investigating-the-impact-of-electrical-stimulation-temporal-distribution-on-cortical-network-responses
#6
Francesca Scarsi, Jacopo Tessadori, Michela Chiappalone, Valentina Pasquale
BACKGROUND: The brain is continuously targeted by a wealth of stimuli with complex spatio-temporal patterns and has presumably evolved in order to cope with those inputs in an optimal way. Previous studies investigating the response capabilities of either single neurons or intact sensory systems to external stimulation demonstrated that stimuli temporal distribution is an important, if often overlooked, parameter. RESULTS: In this study we investigated how cortical networks plated over micro-electrode arrays respond to different stimulation sequences in which inter-pulse intervals followed a 1/f (β) distribution, for different values of β ranging from 0 to ∞...
June 12, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28605385/time-dependent-increase-in-the-network-response-to-the-stimulation-of-neuronal-cell-cultures-on-micro-electrode-arrays
#7
Monica L Gertz, Zachary Baker, Sharon Jose, Nathalia Peixoto
Micro-electrode arrays (MEAs) can be used to investigate drug toxicity, design paradigms for next-generation personalized medicine, and study network dynamics in neuronal cultures. In contrast with more traditional methods, such as patch-clamping, which can only record activity from a single cell, MEAs can record simultaneously from multiple sites in a network, without requiring the arduous task of placing each electrode individually. Moreover, numerous control and stimulation configurations can be easily applied within the same experimental setup, allowing for a broad range of dynamics to be explored...
May 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28605368/murine-short-axis-ventricular-heart-slices-for-electrophysiological-studies
#8
Gabriel Peinkofer, Juergen Hescheler, Marcel Halbach
Murine cardiomyocytes have been extensively used for in vitro studies of cardiac physiology and new therapeutic strategies. However, multicellular preparations of dissociated cardiomyocytes are not representative of the complex in vivo structure of cardiomyocytes, non-myocytes and extracellular matrix, which influences both mechanical and electrophysiological properties of the heart. Here we describe a technique to prepare viable ventricular slices of adult mouse hearts with a preserved in vivo like tissue structure, and demonstrate their suitability for electrophysiological recordings...
June 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28597847/mapping-the-fine-structure-of-cortical-activity-with-different-micro-ecog-electrode-array-geometries
#9
Xi Wang, Alexis Gkogkidis, Olga Iljina, Lukas Fiederer, Chiristian Henle, Irina Mader, Jan Kaminsky, Thomas Stieglitz, Mortimer Gierthmuehlen, Tonio Ball
OBJECTIVE: Innovations in micro-electrocorticography (µECoG) electrode array manufacturing now allow for intricate designs with smaller contact diameters and/or pitch (i.e., center-to-center contact distance) down to the sub-mm range. The aims of the present study were: (i) to investigate whether frequency ranges up to 400 Hz can be reproducibly observed in µECoG recordings and (ii) to examine how differences in topographical substructure between these frequency bands and electrode array geometries can be quantified...
June 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28534411/intracellular-and-extracellular-recording-of-spontaneous-action-potentials-in-mammalian-neurons-and-cardiac-cells-with-3d-plasmonic-nanoelectrodes
#10
Michele Dipalo, Hayder Amin, Laura Lovato, Fabio Moia, Valeria Caprettini, Gabriele C Messina, Francesco Tantussi, Luca Berdondini, Francesco De Angelis
Three-dimensional vertical micro- and nanostructures can enhance the signal quality of multielectrode arrays and promise to become the prime methodology for the investigation of large networks of electrogenic cells. So far, access to the intracellular environment has been obtained via spontaneous poration, electroporation, or by surface functionalization of the micro/nanostructures; however, these methods still suffer from some limitations due to their intrinsic characteristics that limit their widespread use...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28531985/enhancement-of-electro-chemical-properties-of-tio2-nanotubes-for-biological-interfacing
#11
D Khudhair, H Amani Hamedani, J Gaburro, S Shafei, S Nahavandi, H Garmestani, A Bhatti
Micro/nano electrodes employing nanotubes has attracted paramount attention in recent years due to their inherent superior mechanical and structural properties. Electrical interfaces with different geometries and sizes have been developed as electrodes for measuring action potentials and investigating neural information processing in neural networks. In this work, we investigated the possibility of using TiO2 nanotube arrays that were grown using electrochemical anodization technique, as a micro/nano electrode for neural interfacing...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28493361/vertically-aligned-niobium-nanowire-arrays-for-fast-charging-micro-supercapacitors
#12
Seyed M Mirvakili, Ian W Hunter
Planar micro-supercapacitors are attractive for system on chip technologies and surface mount devices due to their large areal capacitance and energy/power density compared to the traditional oxide-based capacitors. In the present work, a novel material, niobium nanowires, in form of vertically aligned electrodes for application in high performance planar micro-supercapacitors is introduced. Specific capacitance of up to 1 kF m(-2) (100 mF cm(-2) ) with peak energy and power density of 2 kJ m(-2) (6.2 MJ m(-3) or 1...
May 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28454981/neuropharmacological-characterization-of-the-new-psychoactive-substance-methoxetamine
#13
Laura Hondebrink, Emma E J Kasteel, Anke M Tukker, Fiona M J Wijnolts, Anouk H A Verboven, Remco H S Westerink
The use of new psychoactive substances (NPS) is steadily increasing. One commonly used NPS is methoxetamine (MXE), a ketamine analogue. Several adverse effects have been reported following MXE exposure, while only limited data are available on its neuropharmacological modes of action. We investigated the effects of MXE and ketamine on several endpoints using multiple in vitro models. These included rat primary cortical cells, human SH-SY5Y cells, human induced pluripotent stem cell (hiPSC)-derived iCell(®) Neurons, DopaNeurons and astrocyte co-cultures, and human embryonic kidney (HEK293) cells...
April 25, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28442997/high-spatiotemporal-resolution-ecog-recording-of-somatosensory-evoked-potentials-with-flexible-micro-electrode-arrays
#14
Taro Kaiju, Keiichi Doi, Masashi Yokota, Kei Watanabe, Masato Inoue, Hiroshi Ando, Kazutaka Takahashi, Fumiaki Yoshida, Masayuki Hirata, Takafumi Suzuki
Electrocorticogram (ECoG) has great potential as a source signal, especially for clinical BMI. Until recently, ECoG electrodes were commonly used for identifying epileptogenic foci in clinical situations, and such electrodes were low-density and large. Increasing the number and density of recording channels could enable the collection of richer motor/sensory information, and may enhance the precision of decoding and increase opportunities for controlling external devices. Several reports have aimed to increase the number and density of channels...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28397927/colloidal-assembly-and-3d-shaping-by-dielectrophoretic-confinement
#15
Ahmet Faik Demirörs, Jérôme J Crassous
For decades, scientists and engineers have strived to design means of assembling colloids into ordered structures. By now, the literature is quite peppered with reports of colloidal assemblies. However, the available methods can assemble only a narrow range of structures or are applicable to specific types of colloids. There are still only few generic methods that would lead to arbitrary colloidal arrays or would shape colloidal assemblies into predesigned structures. Here, we first discuss in detail how to spatially control the assembly and crystallization of colloids through the balance of dielectrophoretic and dipolar forces...
May 3, 2017: Soft Matter
https://www.readbyqxmd.com/read/28393841/biomimetic-supercontainers-for-size-selective-electrochemical-sensing-of-molecular-ions
#16
Nathan L Netzer, Indrek Must, Yupu Qiao, Shi-Li Zhang, Zhenqiang Wang, Zhen Zhang
New ionophores are essential for advancing the art of selective ion sensing. Metal-organic supercontainers (MOSCs), a new family of biomimetic coordination capsules designed using sulfonylcalix[4]arenes as container precursors, are known for their tunable molecular recognition capabilities towards an array of guests. Herein, we demonstrate the use of MOSCs as a new class of size-selective ionophores dedicated to electrochemical sensing of molecular ions. Specifically, a MOSC molecule with its cavities matching the size of methylene blue (MB(+)), a versatile organic molecule used for bio-recognition, was incorporated into a polymeric mixed-matrix membrane and used as an ion-selective electrode...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28333641/droplet-size-aware-high-level-synthesis-for-micro-electrode-dot-array-digital-microfluidic-biochips
#17
Zipeng Li, Kelvin Yi-Tse Lai, Po-Hsien Yu, Krishnendu Chakrabarty, Tsung-Yi Ho, Chen-Yi Lee
A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. In recent years, DMFBs based on a microelectrode-dot-array (MEDA) architecture have been demonstrated. However, due to the inherent differences between today's DMFBs and MEDA, existing synthesis solutions for biochemistry mapping cannot be utilized for MEDA biochips. We present the first synthesis approach that can be used for MEDA biochips. We first present a general analytical model for droplet velocity and validate it experimentally using a fabricated MEDA biochip...
June 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28333440/high-packing-density-unidirectional-arrays-of-vertically-aligned-graphene-with-enhanced-areal-capacitance-for-high-power-micro-supercapacitors
#18
Shuanghao Zheng, Zhilin Li, Zhong-Shuai Wu, Yanfeng Dong, Feng Zhou, Sen Wang, Qiang Fu, Chenglin Sun, Liwei Guo, Xinhe Bao
Interfacial integration of a shape-engineered electrode with a strongly bonded current collector is the key for minimizing both ionic and electronic resistance and then developing high-power supercapacitors. Herein, we demonstrated the construction of high-power micro-supercapacitors (VG-MSCs) based on high-density unidirectional arrays of vertically aligned graphene (VG) nanosheets, derived from a thermally decomposed SiC substrate. The as-grown VG arrays showed a standing basal plane orientation grown on a (0001̅) SiC substrate, tailored thickness (3...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28332478/addressed-immobilization-of-biofunctionalized-diatoms-on-electrodes-by-gold-electrodeposition
#19
S Leonardo, D Garibo, M Fernández-Tejedor, C K O'Sullivan, M Campàs
Diatoms are single cell microalgae with a silica shell (frustule), which possess a micro/nanoporous pattern of unparalleled diversity far beyond the possibilities of current micro- and nanofabrication techniques. To explore diatoms as natural three-dimensional nanostructured supports in sensing and biosensing devices, a simple, rapid and stable method to immobilize diatoms via gold electrodeposition is described. In this process, gold microstructures are formed, immobilizing diatoms by entrapment or crossing their nanopores...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28322793/temporal-relation-between-neural-activity-and-neurite-pruning-on-a-numerical-model-and-a-microchannel-device-with-micro-electrode-array
#20
Yohei Kondo, Yuichiro Yada, Tatsuya Haga, Yuzo Takayama, Takuya Isomura, Yasuhiko Jimbo, Osamu Fukayama, Takayuki Hoshino, Kunihiko Mabuchi
Synapse elimination and neurite pruning are essential processes for the formation of neuronal circuits. These regressive events depend on neural activity and occur in the early postnatal days known as the critical period, but what makes this temporal specificity is not well understood. One possibility is that the neural activities during the developmentally regulated shift of action of GABA inhibitory transmission lead to the critical period. Moreover, it has been reported that the shifting action of the inhibitory transmission on immature neurons overlaps with synapse elimination and neurite pruning and that increased inhibitory transmission by drug treatment could induce temporal shift of the critical period...
April 29, 2017: Biochemical and Biophysical Research Communications
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