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https://www.readbyqxmd.com/read/28328611/a-rare-complication-of-cochlear-implantation-after-magnetic-resonance-imaging-reversion-of-the-magnet
#1
Erkan Öztürk, Can Doruk, Kadir Serkan Orhan, Mehmet Çelik, Beldan Polat, Yahya Güldiken
Cochlear implants are mechanical devices used for patients with severe sensory-neural hearing loss, which has an inner magnet. It is proven that 1.5 Tesla magnetic resonance imaging (MRI) scanners are safe to use in patients with cochlear implant. In our patient, the authors aim to introduce a rare complication caused after a 1.5 Tesla MRI scanning and the management of this situation; the reversion of the magnet of the implant without displacement and significance of surgery in management.
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28328511/wireless-power-transfer-strategies-for-implantable-bioelectronics-methodological-review
#2
Kush Agarwal, Rangarajan Jegadeesan, Yong-Xin Guo, Nitish V Thakor
Neural implants have emerged over the last decade as highly effective solutions for the treatment of dysfunctions and disorders of the nervous system. These implants establish a direct, often bidirectional, interface to the nervous system, both sensing neural signals and providing therapeutic treatments. As a result of the technological progress and successful clinical demonstrations, completely implantable solutions have become a reality and are now commercially available for the treatment of various functional disorders...
March 16, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28324952/the-influence-of-the-pre-stimulation-neural-state-on-the-post-stimulation-neural-dynamics-via-distributed-microstimulation-of-the-hippocampus
#3
Mark J Connolly, Robert E Gross, Babak Mahmoudi
In this study we investigated how the neural state influences how the brain responds to electrical stimulation using a 16-channel microelectrode array with 8 stimulation and recording channels implanted in the rat hippocampus. In two experiments we identified the stimulation threshold at which the brain changes to an afterdischarge state. In one experiment a range of suprathreshold stimulations were applied, and in another the stimulation was not changed. The neural state was measured by the power spectral density prior to stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322213/chronic-monitoring-of-lower-urinary-tract-activity-via-a-sacral-dorsal-root-ganglia-interface
#4
Abeer Khurram, Shani Ross, Zachariah Sperry, Aileen Ouyang, Christopher Stephan, Ahmad Jiman, Tim M Bruns
OBJECTIVE: Our goal is to develop an interface that integrates chronic monitoring of lower urinary tract (LUT) activity with stimulation of peripheral pathways. APPROACH: Penetrating microelectrodes were implanted in sacral dorsal root ganglia (DRG) of adult male felines. Peripheral electrodes were placed on or in the pudendal nerve, bladder neck and near the external urethral sphincter. Supra-pubic bladder catheters were implanted for saline infusion and pressure monitoring...
March 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28316564/functional-circuitry-effect-of-ventral-tegmental-area-deep-brain-stimulation-imaging-and-neurochemical-evidence-of-mesocortical-and-mesolimbic-pathway-modulation
#5
Megan L Settell, Paola Testini, Shinho Cho, Jannifer H Lee, Charles D Blaha, Hang J Jo, Kendall H Lee, Hoon-Ki Min
Background: The ventral tegmental area (VTA), containing mesolimbic and mesocortical dopaminergic neurons, is implicated in processes involving reward, addiction, reinforcement, and learning, which are associated with a variety of neuropsychiatric disorders. Electrical stimulation of the VTA or the medial forebrain bundle and its projection target the nucleus accumbens (NAc) is reported to improve depressive symptoms in patients affected by severe, treatment-resistant major depressive disorder (MDD) and depressive-like symptoms in animal models of depression...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28288908/human-centromedian-parafascicular-complex-signals-sensory-cues-for-goal-oriented-behavior-selection
#6
Inga M Schepers, Anne-Kathrin Beck, Susann Bräuer, Kerstin Schwabe, Mahmoud Abdallat, Pascale Sandmann, Reinhard Dengler, Jochem W Rieger, Joachim K Krauss
Experimental research has shown that the centromedian-parafascicular complex (CM-Pf) of the intralaminar thalamus is activated in attentional orienting and processing of behaviorally relevant stimuli. These observations resulted in the hypothesis that the CM-Pf plays a pivotal role in goal-oriented behavior selection. We here set out to test this hypothesis with electrophysiological recordings from patients with electrodes implanted in CM-Pf for deep brain stimulation (DBS) treatment of chronic neuropathic pain...
March 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28287078/the-design-of-and-chronic-tissue-response-to-a-composite-nerve-electrode-with-patterned-stiffness
#7
Max Freeberg, Matthew Stone, Ronald Triolo, Dustin Tyler
As neural interfaces demonstrate success in chronic applications, a novel class of reshaping electrodes with patterned regions of stiffness will enable application to a widening range of anatomical locations. Patterning stiff regions and flexible regions of the electrode enables nerve reshaping while accommodating anatomical constraints of various implant locations ranging from peripheral nerves to spinal and autonomic plexi. Introduced is a new composite electrode enabling patterning of regions of various electrode mechanical properties...
March 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28282030/platelet-rich-plasma-for-regeneration-of-neural-feedback-pathways-around-dental-implants-a-concise-review-and-outlook-on-future-possibilities
#8
REVIEW
Yan Huang, Michael M Bornstein, Ivo Lambrichts, Hai-Yang Yu, Constantinus Politis, Reinhilde Jacobs
Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge...
March 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28269702/predicting-seizures-from-local-field-potentials-recorded-via-intracortical-microelectrode-arrays
#9
Mehdi Aghagolzadeh, Leigh R Hochberg, Sydney S Cash, Wilson Truccolo
The need for new therapeutic interventions to treat pharmacologically resistant focal epileptic seizures has led recently to the development of closed-loop systems for seizure control. Once a seizure is predicted/detected by the system, electrical stimulation is delivered to prevent seizure initiation or spread. So far, seizure prediction/detection has been limited to tracking non-invasive electroencephalogram (EEG) or intracranial EEG (iEEG) signals. Here, we examine seizure prediction based on local field potentials (LFPs) from a small neocortical patch recorded via a 10×10 microelectrode array implanted in a patient with focal seizures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269693/a-short-impulse-uwb-bpsk-transmitter-for-large-scale-neural-recording-implants
#10
M Rezaei, H Bahrami, A Mirbozorgi, Leslie A Rusch, B Gosselin
In this paper, a short-impulse ultra-wide band (UWB) transmitter is introduced to enable large-scale neural recordings within miniature brain implants including thousands of channels. The proposed impulse radio UWB transmitter uses a BPSK modulation scheme, the carrier signal of which uses only two delayed impulses to encode the transmitted signal. The proposed UWB transmitter has been implemented into a CMOS 180 nm technology. It occupies 300 μm × 230 μm, and consumes only 6.7 pJ/bit from a 1.8-V supply...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269662/in-vitro-evaluation-of-the-long-term-stability-of-pedot-pss-coated-microelectrodes-for-chronic-recording-and-electrical-stimulation-of-neurons
#11
A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang
For the chronic application of neural prostheses long-term stable microelectrodes for electrical stimulation are essential. In recent years many developments were done to investigate different appropriate materials for these electrodes. One of these materials is the electrical conductive polymer PEDOT, which has low impedance and high charge injection capacity. However, the long-term stability of this polymer is still unclear. Thus this paper reports on the in-vitro evaluation of the long-term stability of PEDOT coated gold microelectrodes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269558/a-110-nw-in-channel-sigma-delta-converter-for-large-scale-neural-recording-implants
#12
M Rezaei, E Maghsoudloo, M Sawan, B Gosselin
Advancement in wireless and microsystems technology have ushered in new devices that can directly interface with the central nervous system for stimulating and/or monitoring neural circuitry. In this paper, we present an ultra low-power sigma-delta analog-to-digital converter (ADC) intended for utilization into large-scale multi-channel neural recording implants. This proposed design, which provides a resolution of 9 bits using a one-bit oversampled ADC, presents several desirable features that allow for an in-channel ADC scheme, where one sigma-delta converter is provided for each channel, enabling development of scalable systems that can interface with different types of high-density neural microprobes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269552/ecog-data-analyses-to-inform-closed-loop-bci-experiments-for-speech-based-prosthetic-applications
#13
Tejaswy Pailla, Werner Jiang, Benjamin Dichter, Edward F Chang, Vikash Gilja
Brain Computer Interfaces (BCIs) assist individuals with motor disabilities by enabling them to control prosthetic devices with their neural activity. Performance of closed-loop BCI systems can be improved by using design strategies that leverage structured and task-relevant neural activity. We use data from high density electrocorticography (ECoG) grids implanted in three subjects to study sensory-motor activity during an instructed speech task in which the subjects vocalized three cardinal vowel phonemes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269360/development-of-high-impedance-measurement-system-for-water-leakage-detection-in-implantable-neuroprosthetic-devices
#14
Aziz Yousif, Shawn K Kelly
There has been a push for a greater number of channels in implantable neuroprosthetic devices; but, that number has largely been limited by current hermetic packaging technology. Microfabricated packaging is becoming reality, but a standard testing system is needed to prepare these devices for clinical trials. Impedance measurements of electrodes built into the packaging layers may give an early warning of device failure and predict device lifetime. Because the impedance magnitudes of such devices can be on the order of gigaohms, a versatile system was designed to accommodate ultra-high impedances and allow future integrated circuit implementation in current neural prosthetic technologies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269279/preparation-of-a-neural-electrode-implantation-device-for-in-vivo-surgical-use
#15
Omar Tawakol, Samuel D Bredeson, Philip R Troyk
An instrument designed for the implantation of neural electrode array devices has been refined in preparation for use in cortical implantation procedures in non-human primates. This instrument has undergone extensive testing to ensure its successful first use in a live surgical setting. This work describes the modifications made to the instrument and the testing performed on it during that preparatory period as well as planned future modifications and augmentations.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269278/in-vitro-assessment-of-long-term-reliability-of-low-cost-%C3%AE-ecog-arrays
#16
Kay Palopoli-Trojani, Virginia Woods, Chia-Han Chiang, Michael Trumpis, Jonathan Viventi
Micro-electrocorticographic (μECοG) electrode arrays provide a minimally invasive, high-resolution neural interface with broad cortical coverage. Previously, we fabricated μECoG arrays at a lower cost than commercially available devices using low-cost industrial processes [1], [2]. Here, we report the in vitro electrical performance of five μECoG designs undergoing an accelerated aging protocol. The impedance and yield of the μECoG arrays were tracked over time. The equivalent lifetime at 37°C depended on the manufacturer and material stack-up, and ranged between 30 and greater than 760 days (ongoing)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269276/toward-a-distributed-free-floating-wireless-implantable-neural-recording-system
#17
Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo
To understand the complex correlations between neural networks across different regions in the brain and their functions at high spatiotemporal resolution, a tool is needed for obtaining long-term single unit activity (SUA) across the entire brain area. The concept and preliminary design of a distributed free-floating wireless implantable neural recording (FF-WINeR) system are presented, which can enabling SUA acquisition by dispersedly implanting tens to hundreds of untethered 1 mm3 neural recording probes, floating with the brain and operating wirelessly across the cortical surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269272/a-pdms-based-optical-waveguide-for-transcutaneous-powering-of-microelectrode-arrays
#18
Ali Ersen, Mesut Sahin
Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered, both in neural recording and stimulation applications. Interconnecting wires between implanted electrodes and the outside world constitute a major source of complications. Our solution to this tethering problem is to design a light waveguide that can collect the optical power transcutaneously and transmit it to the microelectrode array where it is to be converted to an electric current. A polydimethylsiloxane (PDMS)-based waveguide was fabricated and its attenuation was measured in vitro and found to be 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269269/suitability-of-nitinol-electrodes-in-neural-prostheses-such-as-endovascular-neural-interfaces
#19
Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden
A major challenge facing neural prostheses is the development of electrodes that are well tolerated by the brain and body. A novel way to circumvent the need to perform an invasive craniotomy and penetration of the blood-brain barrier to implant electrodes, is to guide electrodes up into the cerebral veins and place electrodes on the vessel walls adjacent to neuronal populations. To aid in the development of these stent based devices, microelectrodes manufactured from Nitinol would allow electrodes to be implanted via a catheter and then once deployed, alter their shape to conform to the vessel walls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269267/feasibility-of-a-chronic-minimally-invasive-endovascular-neural-interface
#20
Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley
Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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