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https://www.readbyqxmd.com/read/29352771/severe-cutaneous-adverse-reactions-due-to-inappropriate-medication-use
#1
G Chaby, L Valeyrie-Allanore, T A Duong, B Lebrun-Vignes, B Milpied, B Sassolas, F Tetart, P Wolkenstein, O Chosidow, L Fardet
BACKGROUD: The proportion of severe cutaneous adverse reactions (SCARs) that could be avoided if medication use was consistent with good medical practice is unknown. OBJECTIVES: To estimate the proportion of SCARs related to inappropriate medication use. METHODS: Retrospective study of all validated SCARs collected in a French registry between 2003 and 2016. For each case, all plausible drugs suspected to induce SCARs (i.e., not just the drug regarded as "the most probable") were considered regarding three causes of preventability: (1) prescription for an inappropriate indication, (2) unintentional rechallenge despite a previous allergy to the drug, or (3) self-medication with prescription medicines...
January 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29352738/persistent-pain-following-common-outpatient-surgeries-in-children-a-multicenter-study-in-italy
#2
Valeria Mossetti, Karen Boretsky, Marinella Astuto, Bruno G Locatelli, David Zurakowski, Rodolfo Lio, Roberta Nicoletti, Valter Sonzogni, Micol Maffioletti, Noemi Vicchio, Giorgio Ivani
INTRODUCTION: The prevalence of persistent postsurgical pain in children is over 20% after major surgeries; however, data are scarce on the prevalence, character, and risk factors among children undergoing common ambulatory surgeries. The primary aim of this study was to evaluate the prevalence of persistent pain following pediatric ambulatory surgery at 1, 3, and 6 months. Secondary aims were to identify risk factors and characterize the pain and consequences of persistent postsurgical pain...
January 20, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#3
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
January 11, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352711/gold-cleaning-methods-for-preparation-of-cell-culture-surfaces-for-self-assembled-monolayers-of-zwitterionic-oligopeptides
#4
Junko Enomoto, Tatsuto Kageyama, Dina Myasnikova, Kisaki Onishi, Yuka Kobayashi, Yoko Taruno, Takahiro Kanai, Junji Fukuda
Self-assembled monolayers (SAMs) have been used to elucidate interactions between cells and material surface chemistry. Gold surfaces modified with oligopeptide SAMs exhibit several unique characteristics, such as cell-repulsive surfaces, micropatterns of cell adhesion and non-adhesion regions for control over cell microenvironments, and dynamic release of cells upon external stimuli under culture conditions. However, basic procedures for the preparation of oligopeptide SAMs, including appropriate cleaning methods of the gold surface before modification, have not been fully established...
January 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29352686/interobserver-and-intraobserver-reliability-of-computed-tomography-based-three-dimensional-preoperative-planning-for-primary-total-knee-arthroplasty
#5
Michiaki Miura, Shigeo Hagiwara, Junichi Nakamura, Yasushi Wako, Yuya Kawarai, Seiji Ohtori
BACKGROUND: Preoperative planning is an important factor for total knee arthroplasty (TKA). The aim of this study is to document the interobserver and intraobserver reliability of computed tomography (CT)-based 3-dimensional (3D) preoperative planning for primary TKA. METHODS: Twenty knees (10 with osteoarthritis and 10 with rheumatoid arthritis) were studied independently by 6 orthopedic surgeons using a CT-based 3D planning system. The measurements were made twice at more than 3-week intervals without any knowledge of their own previous measurements or those of the others...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352641/can-you-do-health-disparities-research-with-publicly-available-datasets
#6
Danny R Hughes
RATIONALE AND OBJECTIVES: Given the growing importance of identifying and reducing health disparities, it is important for radiologist researchers to engage in this space to promote evidence-based imaging disparities policy. However, researchers are often hindered by access to appropriate data to perform quality research. MATERIALS AND METHODS: This paper reviews existing publicly available data sets that may be useful for performing imaging disparities research...
January 15, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29352496/microcystic-adnexal-carcinoma-with-sebaceous-differentiation-three-cases
#7
Angel Fernandez-Flores, Mar Llamas-Velasco, Carles Saus, Anisha Patel, Arno Rutten
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend an solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only three cases of MAC with sebaceous differentiation in the literature, and all of them are previous to adipophilin, which in the appropriate context (for example testing clear cells for sebaceous versus eccrine differentiation) is very useful...
January 20, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29352492/variability-of-pulsed-energy-outputs-from-three-dermatology-lasers-during-multiple-simulated-treatments
#8
J Britton
BACKGROUND: Dermatology laser treatments are undertaken at regional departments using lasers of different powers and wavelengths. In order to achieve good outcomes there need to be good consistency of laser output across different weeks as it is custom and practice to break down the treatments into individual fractions. Departments will also collect information from test patches to help decide on the most appropriate treatment parameters for individual patients. OBJECTIVES: The objective of these experiments is to assess the variability of the energy outputs from a small number of lasers across multiple weeks at realistic parameters...
January 20, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29352486/adverse-effects-of-amphotericin-b-in-children-a-retrospective-comparison-of-conventional-and-liposomal-formulations
#9
Eden C Andrew, Nigel Curtis, Ben Coghlan, Noel Cranswick, Amanda Gwee
AIM: Lipid formulations of amphotericin B, rather than conventional amphotericin (c-amB), are increasingly used despite limited data comparing these preparations in children. Data on the incidence of adverse effects with amphotericin-B at standard doses are scarce. This study aimed to compare the adverse effects associated with standard doses of c-amB and liposomal amphotericin (l-amB) in children. METHODS: Children admitted to the Royal Childrenaposs Hospital Melbourne and treated with c-amB or l-amB between January 2010 and September 2013 were included...
January 19, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29352423/understanding-and-addressing-hair-disorders-in-transgender-individuals
#10
REVIEW
Yi Gao, Toby Maurer, Paradi Mirmirani
In the United States, an increasing number of individuals are identifying as transgender. Males at birth who identify as females are called male-to-female (MTF) transgender individuals or trans women, and females at birth who identify as males are called female-to-male (FTM) transgender individuals or trans men. The transgender patient population possess unique health concerns disparate from those of the general populace. Exogenous hormone therapy for transgender patients leads to changes in the distribution and pattern of hair growth...
January 19, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29352418/effect-of-patient-experience-on-bypassing-a-primary-care-gatekeeper-a-multicenter-prospective-cohort-study-in-japan
#11
Takuya Aoki, Yosuke Yamamoto, Tatsuyoshi Ikenoue, Makoto Kaneko, Morito Kise, Yasuki Fujinuma, Shunichi Fukuhara
BACKGROUND: To discuss how best to implement the gatekeeping functionality of primary care; identifying the factors that cause patients to bypass their primary care gatekeepers when seeking care should be beneficial. OBJECTIVE: To examine the association between patient experience with their primary care physicians and bypassing them to directly obtain care from higher-level healthcare facilities. DESIGN AND METHODS: This prospective cohort study was conducted in 13 primary care clinics in Japan...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352324/efficient-genome-wide-genotyping-strategies-and-data-integration-in-crop-plants
#12
REVIEW
Davoud Torkamaneh, Brian Boyle, François Belzile
Next-generation sequencing (NGS) has revolutionized plant and animal research by providing powerful genotyping methods. This review describes and discusses the advantages, challenges and, most importantly, solutions to facilitate data processing, the handling of missing data, and cross-platform data integration. Next-generation sequencing technologies provide powerful and flexible genotyping methods to plant breeders and researchers. These methods offer a wide range of applications from genome-wide analysis to routine screening with a high level of accuracy and reproducibility...
January 19, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29352322/qportal-a-platform-for-data-driven-biomedical-research
#13
Christopher Mohr, Andreas Friedrich, David Wojnar, Erhan Kenar, Aydin Can Polatkan, Marius Cosmin Codrea, Stefan Czemmel, Oliver Kohlbacher, Sven Nahnsen
Modern biomedical research aims at drawing biological conclusions from large, highly complex biological datasets. It has become common practice to make extensive use of high-throughput technologies that produce big amounts of heterogeneous data. In addition to the ever-improving accuracy, methods are getting faster and cheaper, resulting in a steadily increasing need for scalable data management and easily accessible means of analysis. We present qPortal, a platform providing users with an intuitive way to manage and analyze quantitative biological data...
2018: PloS One
https://www.readbyqxmd.com/read/29352114/binding-of-nufip2-to-roquin-promotes-recognition-and-regulation-of-icos-mrna
#14
Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer
The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3'-UTRs and by inducing mRNA decay. However, it is unknown if other cellular proteins contribute to target control. To identify cofactors of Roquin, we used RNA interference to screen ~1500 genes involved in RNA-binding or mRNA degradation, and identified NUFIP2 as a cofactor of Roquin-induced mRNA decay...
January 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29351999/mll1-promotes-il-7-responsiveness-and-survival-during-b-cell-differentiation
#15
Tao Gan, Bin E Li, Bibhu P Mishra, Kenneth L Jones, Patricia Ernst
B lymphocyte differentiation is an exquisitely regulated homeostatic process resulting in continuous production of appropriately selected B cells. Relatively small changes in gene expression can result in deregulation of this process, leading to acute lymphocytic leukemia (ALL), immune deficiency, or autoimmunity. Translocation of MLL1 (KMT2A) often results in a pro-B cell ALL, but little is known about its role in normal B cell differentiation. Using a Rag1-cre mouse knock-in to selectively delete Mll1 in developing lymphocytes, we show that B cell, but not T cell, homeostasis depends on MLL1...
January 19, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29351907/energy-connections-and-misconnections-across-chemistry-and-biology
#16
Kathryn P Kohn, Sonia M Underwood, Melanie M Cooper
Despite the number of university students who take courses in multiple science disciplines, little is known about how they connect concepts between disciplines. Energy is a concept that underlies all scientific phenomena and, as such, provides an appropriate context in which to investigate student connections and misconnections across disciplines. In this study, university students concurrently enrolled in introductory chemistry and biology were interviewed to explore their perceptions of the integration of energy both within and across the disciplines, and how they attempted to accommodate and reconcile different disciplinary approaches to energy, to inform future, interdisciplinary course reform...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29351900/employees-perspectives-on-the-facilitators-and-barriers-to-engaging-with-digital-mental-health-interventions-in-the-workplace-qualitative-study
#17
Stephany Carolan, Richard O de Visser
BACKGROUND: Prevalence rates of work-related stress, depression, and anxiety are high, resulting in reduced productivity and increased absenteeism. There is evidence that these conditions can be successfully treated in the workplace, but take-up of psychological treatments among workers is low. Digital mental health interventions delivered in the workplace may be one way to address this imbalance, but although there is evidence that digital mental health is effective at treating stress, depression, and anxiety in the workplace, uptake of and engagement with these interventions remains a concern...
January 19, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29351898/young-people-s-parents-and-professionals-views-on-required-components-of-mobile-apps-to-support-self-management-of-juvenile-arthritis-qualitative-study
#18
Jennifer M Waite-Jones, Rabiya Majeed-Ariss, Joanna Smith, Simon R Stones, Vanessa Van Rooyen, Veronica Swallow
BACKGROUND: There is growing evidence that supporting self-management of Juvenile Arthritis can benefit both patients and professionals. Young people with Juvenile Arthritis and their healthy peers increasingly use mobile technologies to access information and support in day-to-day life. Therefore, a user-led, rigorously developed and evaluated mobile app could be valuable for facilitating young people's self-management of Juvenile Arthritis. OBJECTIVE: The objective of this study was to seek the views of young people with Juvenile Arthritis, their parents or carers, and health care professionals (HCPs) as to what should be included in a mobile app to facilitate young people's self-management of chronic Juvenile Arthritis...
January 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29351715/the-impact-of-migration-background-on-the-health-outcomes-of-preschool-children-linking-a-cross-sectional-survey-to-the-school-entrance-health-examination-database-in-bavaria-germany
#19
Thu Giang Le Thi, Annette Heißenhuber, Thomas Schneider, Rebekka Schulz, Caroline Eva Wella Herr, Uta Nennstiel-Ratzel, Gabriele Hölscher
AIM OF THE STUDY: This study investigated the impact of migration background on the health outcomes of preschool children from families of various social status levels. METHODS: During the school entrance health examination (Schuleingangsuntersuchung (SEU)) from October 2012 to August 2013, the parents of 5052 preschool children (62% response rate) participated in a cross-sectional health survey within the framework of health-monitoring units (Gesundheits-Monitoring-Einheiten (GME)) in Bavaria, Germany...
January 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29351711/-beck-anxiety-inventory-german-version-a-reliable-valid-patientfriendly-instrument-for-measuring-clinical-anxiety
#20
Edgar Geissner, Anne Huetteroth
The Beck Anxiety Inventory (BAI) is available in German. Apart from data in its manual, there are no further reports on the psychometric properties of this questionnaire and on its suitability for clinical use in Germany. This study therefore offers an independent investigation into the psychometrics as well as the clinical characteristics of the BAI. Three samples with n=145, n=90, and n=174 comprised inpatients diagnosed with anxiety disorders and treated in a large psychosomatic hospital. In addition to the BAI, the clinician rating Hamilton Anxiety Scale (HamA), the State-Trait-Anxiety Inventory (STAI) as well as the two anxiety subscales of the Symptom Checklist 90 (SCL 90) were used to establish convergent validity...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
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