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https://www.readbyqxmd.com/read/29908985/biodistribution-and-toxicity-assessment-of-intratumorally-injected-arginine-glycine-aspartic-acid-peptide-conjugated-to-cdse-zns-quantum-dots-in-mice-bearing-pancreatic-neoplasm
#1
Ming-Ming Li, Jia Cao, Jia-Chun Yang, Yu-Jie Shen, Xiao-Lei Cai, Yuan-Wen Chen, Chun-Ying Qu, Yi Zhang, Feng Shen, Min Zhou, Lei-Ming Xu
Quantum dots (QDs) conjugated with arginine-glycine-aspartic acid (RGD) peptides (which are integrin antagonists) are novel nanomaterials with the unique optical property of high molar extinction coefficient, and they have potential utility as photosensitizers in photodynamic therapy (PDT). Our group previously demonstrated significant benefits of using PDT with QD-RGD on pancreatic tumor cells. This study aimed to evaluate the biodistribution and toxicity of QD-RGD in mice prior to in vivo application. Mice with pancreatic neoplasms were intratumorally injected with varying doses of QD-RGD, and the biodistribution 0-24 h post injection was compared to that in control mice (intravenously injected with unconjugated QD)...
June 14, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29907598/clinical-response-of-the-novel-activating-alk-i1171t-mutation-in-neuroblastoma-to-the-alk-inhibitor-ceritinib
#2
Jikui Guan, Susanne Fransson, Joachim Tetteh T Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Petter Svenberg, Kristina Ruuth, Sandra Wessman, Alia Shamikh, Hans Jacobsson, Lena Gordon, Jakob Stenman, Erik Larsson, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H Palmer, Bengt Hallberg
Tumors with Anaplastic Lymphoma Kinase (ALK) fusion rearrangements, including non-small cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. While mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been disappointing. Embryonal tumors in patients with DNA repair defects such as Fanconi anemia (FA) often have a poor prognosis, due to lack of therapeutic options...
June 15, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29905005/targeting-mct4-to-reduce-lactic-acid-secretion-and-glycolysis-for-treatment-of-neuroendocrine-prostate-cancer
#3
Stephen Yiu Chuen Choi, Susan L Ettinger, Dong Lin, Hui Xue, Xinpei Ci, Noushin Nabavi, Robert H Bell, Fan Mo, Peter W Gout, Neil E Fleshner, Martin E Gleave, Colin C Collins, Yuzhuo Wang
Development of neuroendocrine prostate cancer (NEPC) is emerging as a major problem in clinical management of advanced prostate cancer (PCa). As increasingly potent androgen receptor (AR)-targeting antiandrogens are more widely used, PCa transdifferentiation into AR-independent NEPC as a mechanism of treatment resistance becomes more common and precarious, since NEPC is a lethal PCa subtype urgently requiring effective therapy. Reprogrammed glucose metabolism of cancers, that is elevated aerobic glycolysis involving increased lactic acid production/secretion, plays a key role in multiple cancer-promoting processes and has been implicated in therapeutics development...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29903893/living-without-a-pulse-the-vascular-implications-of-continuous-flow-left-ventricular-assist-devices
#4
Suneet N Purohit, William K Cornwell, Jay D Pal, JoAnn Lindenfeld, Amrut V Ambardekar
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29902784/predictors-of-utilization-of-an-addiction-specific-behavioural-couple-therapy-in-alcohol-dependence
#5
Olivia Schünemann, Johannes Lindenmeyer, Nina Heinrichs
PURPOSE: The aim of this study was to examine predictors that lead to the utilization of Behavioural Couple Therapy (BCT) for patients with alcohol dependence (AD) in a -European health care system and to identify groups that have a low probability of utilizing BCT. METHODS: Using routinely collected data from a German rehabilitation clinic, a sample of 1,843 inpatients with AD living in a couple relationship was examined. Each patient could freely choose to participate in an addiction-specific BCT as a voluntary additional intervention during an inpatient treatment program...
June 14, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29902692/quantification-of-nucleotides-and-their-sugar-conjugates-in-biological-samples-purposes-instruments-and-applications
#6
REVIEW
Xuan Qin, Xin Wang
Nucleotides and their sugar conjugates are fundamental molecules in life, participating in processes of DNA/RNA composition, cell wall build-up, glycosylation reactions, and signal conduction. Therefore, the quantification of these compounds in biological samples significantly benefits the understanding of their functions. However, nucleotides and nucleotide sugars are extremely hydrophilic, causing bad retention and peak symmetry on regular C18 chromatographic columns. To solve this problem, ion-pair (IP) chromatography, ion-exchange (IE) chromatography and hydrophilic interaction chromatography (HILIC) were applied, of which differentiated mechanisms were utilized to increase the retention of the analytes on the stationary phases...
June 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29902211/clinical-effectiveness-of-family-therapeutic-interventions-in-the-prevention-and-treatment-of-perinatal-depression-a-systematic-review-and-meta-analysis
#7
Fallon Cluxton-Keller, Martha L Bruce
BACKGROUND: Family therapy is a potential strategy to increase family support for those suffering from perinatal depression. Family therapeutic interventions for this population typically target depressed women and their adult family members to improve family functioning and reduce depressive symptoms. OBJECTIVE: This systematic review and meta-analysis is a synthesis of the current evidence on the usefulness of family therapy interventions in the prevention and treatment of perinatal depression and impacts on maternal depressive symptoms and family functioning...
2018: PloS One
https://www.readbyqxmd.com/read/29899876/hypoxia-targeted-gold-nanorods-for-cancer-photothermal-therapy
#8
Yuan Chen, Xiaomei Bian, Maureen Aliru, Amit A Deorukhkar, Oscar Ekpenyong, Su Liang, Jyothy John, Jing Ma, Xiuqing Gao, Jon Schwartz, Pankaj Singh, Yuanqing Ye, Sunil Krishnan, Huan Xie
Tumor hypoxia is a well-recognized driver of resistance to traditional cancer therapies such as chemotherapy and radiation therapy. We describe development of a new nanoconstruct composed of gold nanorods (GNRs) conjugated to carbonic anhydrase IX (CAIX) antibody that specifically binds to CAIX, a biomarker of hypoxia, to facilitate targeting tumor hypoxic areas for focused photothermal ablation. Physicochemical characterization studies confirmed the size, shape, monodispersity, surface charge, and serum stability of the GNRs...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29898892/mitochondrial-ros-drive-sudden-cardiac-death-and-chronic-proteome-remodeling-in-heart-failure
#9
Swati Dey, Deeptankar DeMazumder, Agnieszka Sidor, D B Foster, Brian O'Rourke
<u>Rationale:</u> Despite increasing prevalence and incidence of heart failure (HF), therapeutic options remain limited. In early stages of HF, sudden cardiac death (SCD) from ventricular arrhythmias claims many lives. Reactive oxygen species (ROS) have been implicated in both arrhythmias and contractile dysfunction. However, little is known about how ROS in specific subcellular compartments contribute to HF or SCD pathophysiology. The role of ROS in chronic proteome remodeling has not been explored...
June 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29898649/bpc157-as-potential-agent-rescuing-from-cancer-cachexia
#10
Eun A Kang, Young Min Han, Jeong Min An, Yong Jin Park, Predrag Sikiric, Deok Hwan Kim, Kwang An Kwon, Yoon Jae Kim, Donghwa Yang, Hann Tchah, Ki Baik Hahm
Cancer cachexia, one of the metabolic syndromes caused by cancer, is a devastating and miserable condition encountered in more than 50% of terminal cancer patients presenting with significant weight loss associated with skeletal muscle atrophy and fat loss. Though cachexia may account for up to 20% of cancer deaths, no significant treatment is still lacking and is of urgent unmet medical need in cancer treatment. Therefore, understanding the underlying molecular mechanisms is essential for anticipating therapeutic approaches...
June 13, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29896107/construction-and-validation-of-subject-specific-biventricular-finite-element-models-of-healthy-and-failing-swine-hearts-from-high-resolution-dt-mri
#11
Kevin L Sack, Eric Aliotta, Daniel B Ennis, Jenny S Choy, Ghassan S Kassab, Julius M Guccione, Thomas Franz
Predictive computational modeling has revolutionized classical engineering disciplines and is in the process of transforming cardiovascular research. This is particularly relevant for investigating emergent therapies for heart failure, which remains a leading cause of death globally. The creation of subject-specific biventricular computational cardiac models has been a long-term endeavor within the biomedical engineering community. Using high resolution (0.3 × 0.3 × 0.8 mm) ex vivo data, we constructed a precise fully subject-specific biventricular finite-element model of healthy and failing swine hearts...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29895379/evaluation-of-the-uptake-storage-and-cell-effects-of-nano-iron-in-enterocyte-like-cell-models
#12
Daniel Turiel-Fernández, Jörg Bettmer, Maria Montes-Bayón
The therapy with nanocompounds is widely used to treat Fe deficiency and an emerging trend to inhibit tumor growth. The present work aims to address the management of different FeONP, comparing sucrose covered FeONP and Fe nanoparticles in the form of the ferritin with non-particulated inorganic Fe (II) by enterocytes-like colon cancer cell lines (Caco-2 and HT-29). Iron uptake results revealed significantly higher Fe incorporation in the case of nanoparticulated Fe, first in the form of FeONP and second in the form of ferritin with respect to inorganic Fe (II)...
September 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29893928/physical-therapist-physical-therapist-assistant-and-student-response-to-inappropriate-patient-sexual-behavior-results-of-a-national-survey
#13
Ziádee Cambier, Jill S Boissonnault, Scott J Hetzel, Margaret M Plack
Background: A recent survey found that 84% of physical therapist, physical therapist assistant, and student respondents experienced inappropriate patient sexual behavior (IPSB) over their careers and 47% over the prior 12 months. Prevalence data justify consideration of how to address IPSB. Objective: The objective was to determine how physical therapist clinicians (used here to mean physical therapists, physical therapist assistants, and students) address IPSB and examine strategy impact...
June 8, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29892041/effectiveness-of-vitamin-d-therapy-in-improving-metabolomic-biomarkers-in-obesity-phenotypes-two-randomized-clinical-trials
#14
Farshad Farzadfar, Abolghasem Djazayery, Lu Qi, Minoo Bagheri, Mir Saeed Yekaninejad, Maryam Chamari, Maryam Naderi, Zarin Ebrahimi, Berthold Koletzko, Olaf Uhl
BACKGROUND: Uncertainty remains about the effect of vitamin D therapy on biomarkers of health status in obesity. The molecular basis underlying this controversy is largely unknown. OBJECTIVE: To address the existing gap, our study sought to compare changes in metabolomic profiles of obesity phenotypes (metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO)) patients with sub-optimal levels of vitamin D following vitamin D supplementation. METHODS: We conducted two randomized double-blind clinical trials on participants with either of the two obesity phenotypes from Tehran province...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29891030/the-history-of-proximal-carotid-protection-and-flow-reversal-to-prevent-stent-angioplasty-embolization
#15
Juan Parodi, Mark C Bates, Takao Ohki, Claudio Schönholz
Innovation in medicine is often driven by the observations of imaginative physicians who are blessed with insatiable curiosity, coupled with the inability to accept technical boundaries, the status quo of patient care, or the acceptance of procedural morbidity. Few examples illustrate this truism better than the physician-originated clinical research that transformed the safety of carotid stent angioplasty over the last 2 decades. Initial clinical application of carotid stenting suggested that proximal protection may be a better approach to prevent embolic stroke during the angioplasty procedure...
March 2018: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/29891016/melatonin-ameliorates-h-2-o-2-induced-oxidative-stress-through-modulation-of-erk-akt-nfkb-pathway
#16
Mahammed Moniruzzaman, Indranath Ghosal, Debjit Das, Suman Bhusan Chakraborty
BACKGROUND: Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative damage in different vertebrates. Aim of the current communication is to evaluate the levels of oxidative stress and ROS induced damage, and amelioration of oxidative status through melatonin induced activation of signaling pathways. Hepatocytes were isolated from adult Labeo rohita and exposed to H2 O2 at three different doses (12...
June 11, 2018: Biological Research
https://www.readbyqxmd.com/read/29889655/plasticity-of-retinal-gap-junctions-roles-in-synaptic-physiology-and-disease
#17
John O'Brien, Stewart A Bloomfield
Electrical synaptic transmission via gap junctions underlies direct and rapid neuronal communication in the central nervous system. The diversity of functional roles played by electrical synapses is perhaps best exemplified in the vertebrate retina in which gap junctions are expressed by each of the five major neuronal types. These junctions are highly plastic; they are dynamically regulated by ambient illumination and circadian rhythms acting through light-activated neuromodulators. The networks formed by electrically coupled neurons provide plastic, reconfigurable circuits positioned to play key and diverse roles in the transmission and processing of visual information at every retinal level...
June 11, 2018: Annual Review of Vision Science
https://www.readbyqxmd.com/read/29888135/bioheat-transfer-model-of-transcutaneous-spinal-cord-stimulation-induced-temperature-changes
#18
Luyao Chen, Ang Ke, Peng Zhang, Zhaolong Gao, Xuecheng Zou, Jiping He
Transcutaneous spinal cord stimulation (tSCS) has been extensively studied due to its promising application in motor function restoration. Many previous studies have explored both the essential mechanism of action and the methods for determining optimal stimulation parameters. In contrast, the bioheat transfer analysis of tSCS therapy has not been investigated to the same extent, despite widely existing, and being of great significance in assuring a stable and thermally safe treatment. In this paper, we concentrated on the thermal effects of tSCS using a finite element-based method...
2018: PeerJ
https://www.readbyqxmd.com/read/29887943/coupling-of-pulsed-electromagnetic-fields-pemf-therapy-to-molecular-grounds-of-the-cell
#19
REVIEW
Richard Hw Funk
In this review we compile results cited in reliable journals that show a ratio for the use of pulsed electromagnetic fields (PEMF) in therapy, indeed. This is true especially for chronically inflamed joints. Furthermore, we try to link this therapeutic approach to the molecular background of chronic inflammation and arthritis. At first we start with the clinical outcome of PEMF therapy. Then, we look for possible triggers and an electromagnetic counterpart that is endogenously inherent in cell biology and in the tissues of interest...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29886354/remodeling-of-the-hdl-proteome-with-treatment-response-to-abatacept-or-adalimumab-in-the-ample-trial-of-patients-with-rheumatoid-arthritis
#20
C Charles-Schoeman, G B Gugiu, H Ge, A Shahbazian, Y Y Lee, X Wang, D E Furst, V K Ranganath, M Maldonado, Terry Lee, S T Reddy
BACKGROUND AND AIMS: To evaluate changes in the high-density lipoprotein (HDL) proteome and HDL function in active rheumatoid arthritis (RA) patients initiating therapy with abatacept or adalimumab in the Abatacept Versus Adalimumab Comparison in Biologic-Naïve RA Subjects with Background Methotrexate (AMPLE) study. METHODS: Ultra high-pressure liquid chromatography (UHPLC) coupled with ion mobility mass spectrometry (LC-IM-MS) was used to analyze proteins associated with immunoaffinity-captured HDL from plasma of 30 patients with RA randomized to either abatacept (n = 15) or adalimumab (n = 15) therapy...
April 17, 2018: Atherosclerosis
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