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https://www.readbyqxmd.com/read/29471280/stretchable-wireless-system-for-sweat-ph-monitoring
#1
Wenting Dang, Libu Manjakkal, William Taube Navaraj, Leandro Lorenzelli, Vincenzo Vinciguerra, Ravinder Dahiya
Sensor-laden wearable systems that are capable of providing continuous measurement of key physiological parameters coupled with data storage, drug delivery and feedback therapy have attracted huge interest. Here we report a stretchable wireless system for sweat pH monitoring, which is able to withstand up to 53% uniaxial strain and more than 500 cycles to 30% strain. The stretchability of the pH sensor patch is provided by a pair of serpentine-shaped stretchable interconnects. The pH sensing electrode is made of graphite-polyurethane composite, which is suitable for biosensor application...
February 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29470420/enhanced-antitumor-effects-of-epidermal-growth-factor-receptor-targetable-cetuximab-conjugated-polymeric-micelles-for-photodynamic-therapy
#2
Ming-Hsiang Chang, Chin-Ling Pai, Ying-Chen Chen, Hsiu-Ping Yu, Chia-Yen Hsu, Ping-Shan Lai
Nanocarrier-based delivery systems are promising strategies for enhanced therapeutic efficacy and safety of toxic drugs. Photodynamic therapy (PDT)-a light-triggered chemical reaction that generates localized tissue damage for disease treatments-usually has side effects, and thus patients receiving photosensitizers should be kept away from direct light to avoid skin phototoxicity. In this study, a clinically therapeutic antibody cetuximab (C225) was conjugated to the surface of methoxy poly(ethylene glycol)- b -poly(lactide) (mPEG- b -PLA) micelles via thiol-maleimide coupling to allow tumor-targetable chlorin e6 (Ce6) delivery...
February 22, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29468941/the-serotonin-hypothesis-in-pulmonary-hypertension-revisited-targets-for-novel-therapies-2017-grover-conference-series
#3
Margaret Mandy R MacLean
Increased synthesis of serotonin and/or activity of serotonin in pulmonary arteries has been implicated in the pathobiology of pulmonary arterial hypertension (PAH). The incidence of PAH associated with diet pills such as aminorex, fenfluramine, and chlorphentermine initially led to the "serotonin hypothesis of pulmonary hypertension." Over the last couple of decades there has been an accumulation of convincing evidence that targeting serotonin synthesis or signaling is a novel and promising approach to the development of novel therapies for PAH...
April 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29468160/adhesion-gpcrs-in-kidney-development-and-disease
#4
REVIEW
Salvador Cazorla-Vázquez, Felix B Engel
Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a prevalence of >10% in many countries. In addition, kidney cancer represents 5% of all new diagnosed cancers. As currently no effective therapies exist to restore kidney function after CKD- as well as cancer-induced renal damage, it is important to elucidate new regulators of kidney development and disease as new therapeutic targets. G protein-coupled receptors (GPCRs) represent the most successful class of pharmaceutical targets...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29468076/capromorelin-a-ghrelin-receptor-agonist-and-novel-therapy-for-stimulation-of-appetite-in-dogs
#5
REVIEW
Linda Rhodes, Bill Zollers, Jessica A Wofford, Ernst Heinen
Ghrelin is a hormone, secreted from cells in the stomach, which is important in the regulation of appetite and food intake in mammals. It exerts its action by binding to a specific G-protein-coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1a) which is found in areas of the brain associated with the regulation of food intake. Ghrelin causes a release of growth hormone (GH) through binding to GHS-R1a in the hypothalamus and pituitary gland. A class of compounds known as growth hormone secretagogues, or ghrelin receptor agonists, were developed for therapeutic use in humans for the stimulation of GH in the frail elderly, and have subsequently been studied for their effects on increasing appetite and food intake, increasing body weight, building lean muscle mass, and treating cachexia...
February 2018: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29467655/atherosclerosis-is-an-inflammatory-disease-which-lacks-a-common-anti-inflammatory-therapy-how-human-genetics-can-help-to-this-issue-a-narrative-review
#6
REVIEW
Cristiano Fava, Martina Montagnana
Atherosclerosis is a multifactorial disease triggered and sustained by different risk factors such as dyslipidemia, arterial hypertension, diabetes mellitus, smoke, etc. Since a couple of decades, a pivotal role for inflammation in its pathogenesis has been recognized and proved at molecular levels, and already described in many animal models. Despite all this knowledge, due to the complexity of the specific inflammatory process subtending atherosclerosis and to the fact that inflammation is also a protective response against microorganisms, no anti-inflammatory therapy has been rendered available in the therapeutic armamentarium against atherosclerosis and vascular events till 2017 when canakinumab in the first ad-hoc randomized clinical trial (RCT) proved for the first time that targeting specifically inflammation lowers cardiovascular (CV) events...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29467575/nanoscale-polysaccharide-derivative-as-an-aeg-1-sirna-carrier-for-effective-osteosarcoma-therapy
#7
Fen Wang, Jia-Dong Pang, Lei-Lei Huang, Ran Wang, Dan Li, Kang Sun, Lian-Tang Wang, Li-Ming Zhang
Background: Nanomedicine, which is the application of nanotechnology in medicine to make medical diagnosis and treatment more accurate, has great potential for precision medicine. Despite some improvements in nanomedicine, the lack of efficient and low-toxic vectors remains a major obstacle. Objective: The aim of this study was to prepare an efficient and low-toxic vector which could deliver astrocyte elevated gene-1 ( AEG-1 ) small interfering RNA (siRNA; siAEG-1) into osteosarcoma cells effectively and silence the targeted gene both in vitro and in vivo...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29467460/early-antiretroviral-therapy-on-reducing-hiv-transmission-in-china-strengths-weaknesses-and-next-focus-of-the-program
#8
Pengtao Liu, Zhenzhu Tang, Guanghua Lan, Qiuying Zhu, Huanhuan Chen, Yinghui You, Xiaoyi Yang, Shujia Liang, Yi Chen, Hui Xing, Lingjie Liao, Yi Feng, Zhiyong Shen, Yuhua Ruan, Yiming Shao
Early antiretroviral therapy (ART) initiation is a recommended public health approach for the prevention of HIV-1 transmission. In this cohort study, we included 13132 serodiscordant couples. ART was initiated for patients with CD4+ T cell counts less than 200 cells/uL, 350 cells/uL, and 500 cells/uL respectively. This divided the ART treated couples into three groups. Univariate and multivariate intention-to-treat analyses were performed to examine the association between the study groups. Early-ART initiation was associated with a 45% lower risk of partner infection than was late-ART initiation (AHR 0...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467432/printed-receive-coils-with-high-acoustic-transparency-for-magnetic-resonance-guided-focused-ultrasound
#9
Joseph Corea, Patrick Ye, Dongjin Seo, Kim Butts-Pauly, Ana Claudia Arias, Michael Lustig
In magnetic resonance guided focused ultrasound (MRgFUS) therapy sound waves are focused through the body to selectively ablate difficult to access lesions and tissues. A magnetic resonance imaging (MRI) scanner non-invasively tracks the temperature increase throughout the tissue to guide the therapy. In clinical MRI, tightly fitted hardware comprised of multichannel coil arrays are required to capture high quality images at high spatiotemporal resolution. Ablating tissue requires a clear path for acoustic energy to travel but current array materials scatter and attenuate acoustic energy...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466865/regulation-of-nadph-oxidases-by-g-protein-coupled-receptors
#10
Andreas Petry, Agnes Görlach
SIGNIFICANCE: G protein coupled receptors (GPCR) are the largest group of cell-surface receptors which link cells to their environment. Reactive oxygen species (ROS) can act as important cellular signaling molecules. The family of NADPH oxidases generates ROS in response to activated cell-surface receptors. Recent Advances: Various signaling pathways linking GPCRs and activation of NADPH oxidases have been characterized. CRITICAL ISSUES: Still, a more detailed analysis of G proteins involved in the GPCR-mediated activation of NADPH oxidases is needed...
February 21, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29466606/using-attachment-to-better-understand-the-therapy-alliance-the-attachment-based-alliance-questionnaire
#11
Lee N Johnson, Scott A Ketring, Jennifer Espino
Questionnaires on the therapeutic alliance are available, but most show inflated scores, limited variability, and few significant findings on the bonds domain. Results of a study of 251 clinical couples, on the development of an Attachment Based Alliance Questionnaire (ABAQ), are presented. Factor analysis (EFA and CFA), show that a one-factor or two-factor structure fit the data, with more support for a one-factor model. Both models map closely with attachment constructs. Results also show that the ABAQ is predictive of changes couples make early in therapy and demonstrated adequate reliability and validity...
February 21, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29464520/infrared-spectroscopy-and-imaging-in-stem-cells-and-aging-research
#12
Ceren Aksoy, Feride Severcan
The effect of aging process on stem cell function is crucial because of their critical role in tissue regeneration and repair. The impact of aging on stem cells needs to be understood clearly for the success of clinical application and obtaining desired therapeutic outcome throughout the novel stem cell based therapies. The existing methods used to monitor and characterize the stem cells have some unwanted effects on the properties of stem cells and these methods also do not provide real-time information about cellular conditions...
February 21, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29463871/co-treatment-with-clonidine-and-a-grk2-inhibitor-prevented-rebound-hypertension-and-endothelial-dysfunction-after-withdrawal-in-diabetes
#13
Kumiko Taguchi, Nanami Bessho, Mami Hasegawa, Haruka Narimatsu, Takayuki Matsumoto, Tsuneo Kobayashi
Hypertension and diabetes are associated with a risk of cardiovascular disease. Clonidine is currently used as a fourth-line drug therapy for hypertension because of its rebound hypertensive effect and short half-life. The purpose of this study was to investigate the combined effect of an antihypertensive drug (clonidine) and a G-protein-coupled receptor kinase 2 (GRK2) inhibitor on rebound hypertension and endothelial dysfunction. The clonidine and/or GRK2 inhibitor were administered by continuous infusion for 14 days by using an osmotic pump that was implanted subcutaneously...
February 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29463246/next-generation-personalised-model-based-critical-care-medicine-a-state-of-the-art-review-of-in-silico-virtual-patient-models-methods-and-cohorts-and-how-to-validation-them
#14
REVIEW
J Geoffrey Chase, Jean-Charles Preiser, Jennifer L Dickson, Antoine Pironet, Yeong Shiong Chiew, Christopher G Pretty, Geoffrey M Shaw, Balazs Benyo, Knut Moeller, Soroush Safaei, Merryn Tawhai, Peter Hunter, Thomas Desaive
Critical care, like many healthcare areas, is under a dual assault from significantly increasing demographic and economic pressures. Intensive care unit (ICU) patients are highly variable in response to treatment, and increasingly aging populations mean ICUs are under increasing demand and their cohorts are increasingly ill. Equally, patient expectations are growing, while the economic ability to deliver care to all is declining. Better, more productive care is thus the big challenge. One means to that end is personalised care designed to manage the significant inter- and intra-patient variability that makes the ICU patient difficult...
February 20, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29462173/imaging-cellular-pharmacokinetics-of-18f-fdg-and-6-nbdg-uptake-by-inflammatory-and-stem-cells
#15
Raiyan T Zaman, Silvan Tuerkcan, Morteza Mahmoudi, Toshinobu Saito, Phillip C Yang, Frederick T Chin, Michael V McConnell, Lei Xing
OBJECTIVES: Myocardial infarction (MI) causes significant loss of cardiomyocytes, myocardial tissue damage, and impairment of myocardial function. The inability of cardiomyocytes to proliferate prevents the heart from self-regeneration. The treatment for advanced heart failure following an MI is heart transplantation despite the limited availability of the organs. Thus, stem-cell-based cardiac therapies could ultimately prevent heart failure by repairing injured myocardium that reverses cardiomyocyte loss...
2018: PloS One
https://www.readbyqxmd.com/read/29462171/stigma-gets-in-my-way-factors-affecting-client-provider-communication-regarding-childbearing-among-people-living-with-hiv-in-uganda
#16
Jolly Beyeza-Kashesya, Rhoda K Wanyenze, Kathy Goggin, Sarah Finocchario-Kessler, Mahlet Atakilt Woldetsadik, Deborah Mindry, Josephine Birungi, Glenn J Wagner
INTRODUCTION: Many HIV-affected couples living in sub-Saharan Africa desire to have children, but few quantitative studies have examined support for their childbearing needs. Our study explored client-provider communication about childbearing and safer conception among HIV clients in Uganda. METHODS: 400 Ugandan HIV clients in committed relationships and with intentions to conceive were surveyed. Knowledge, attitudes and practices related to childbearing, and use of safer conception methods were assessed, including communication with providers about childbearing needs, the correlates of which were examined with bivariate statistics and logistic multivariate analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29460403/effects-of-ivabradine-on-endothelial-function-aortic-properties-and-ventricular-arterial-coupling-in-chronic-systolic-heart-failure-patients
#17
Ivano Bonadei, Edoardo Sciatti, Enrico Vizzardi, Davide Fabbricatore, Mattia Pagnoni, Laura Rossi, Valentina Carubelli, Carlo M Lombardi, Marco Metra
AIM: Heart rate (HR) is an important prognostic factor in patients affected by chronic heart failure (CHF); ivabradine has been demonstrated to significantly reduce nonfatal myocardial infarction and hospitalization rate for acute heart failure and to improve left ventricular (LV) reverse remodelling, quality of life, exercise capacity and arterial elastance (Ea) in these patients. We aimed at evaluating the short-term effects of ivabradine on ventricular-arterial coupling (VAC), aortic stiffness and endothelial function in stable patients with CHF...
February 20, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29458885/prenatal-diagnosis-of-fetal-glutaric-aciduria-type-1-with-rare-compound-heterozygous-mutations-in-gcdh-gene
#18
Hsiu-Huei Peng, Sheng-Wen Shaw, Kuan-Gen Huang
OBJECTIVE: Glutaric aciduria type 1 is a rare disease, with the estimated prevalence about 1 in 100,000 newborns. GCDH gene mutation can lead to glutaric acid and 3- OH glutaric acid accumulation, with clinical manifestation of neuronal damage, brain atrophy, microencephalic macrocephaly, decreased coordination of swallowing, poor muscle coordination, spasticity, and severe dystonic movement disorder. CASE REPORT: A 22-year-old female, Gravida 4 Para 2, is pregnancy at 13 weeks of gestational age...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29458573/promoted-delivery-of-salinomycin-to-lung-cancer-through-epidermal-growth-factor-receptor-aptamers-coupled-dspe-peg2000-nanomicelles
#19
Dewen Leng, Jun Hu, Xiaolong Huang, Wei He, Yuan Wang, Mei Liu
Initiation and recurrence of lung cancer, the most fatal cancer worldwide, are attributed to lung cancer stem cells (CSCs). Evidence suggests that cancer cells can be turned into CSCs in a spontaneous way, and therefore simultaneous elimination of lung CSCs and cancer cells is crucial to achieve effective therapy of lung cancer. In lung cancer, epidermal growth factor receptor (EGFR) is overexpressed in both CSCs and cancer cells. The present study developed salinomycin poly(ethylene glycol) 2000-distearoylphosphatidylethanolamine nanomicelles conjugated with EGFR aptamers (M-SAL-EGFR) to kill lung CSCs and cancer cells...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29457905/computational-investigation-on-the-influence-of-halogen-atoms-on-the-photophysical-properties-of-tetraphenylporphyrin-and-its-zinc-ii-complexes
#20
Bruna Clara De Simone, Gloria Mazzone, Nino Russo, Emilia Sicilia, Marirosa Toscano
How the tetraphenylporphyrin (TPP) and its zinc (II) complex (ZnTPP) photophysical properties (adsorption energies, singlet-triplet energy gap and spin orbit coupling contributions) can change due to the presence of an increasing number of heavy atoms in their molecular structures has been investigated by means of density functional theory and its time dependent formulation. Results show as the increase of the atomic mass of the substituted halogen strongly enhances the spin-orbit coupling values allowing a more efficient singlet-triplet intersystem crossing...
February 19, 2018: Journal of Physical Chemistry. A
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