Read by QxMD icon Read


Tianzhou Liu, Dawei Zhang, Wantong Song, Zhaohui Tang, Jiaming Zhu, Zhiming Ma, Xudong Wang, Xuesi Chen, Ti Tong
Combretastatin A4 (CA4) is a leading agent in vascular disrupting strategies for tumor therapy. Although many small-molecule prodrugs of CA4 have been developed to improve its solubility, the overall therapeutic efficiency is moderate. A key reason for this is the reversible effect that CA4 has on tubulin as well as its rapid clearance from plasma and tissues. In this study, we proposed a poly(l-glutamic acid)-CA4 conjugate (PLG-CA4) nanomedicine to fulfill the requirements for fully liberating the potential of CA4 on tumor therapy...
April 15, 2017: Acta Biomaterialia
Tanuj Dada, Dewang Angmo, Neha Midha, Talvir Sidhu
Two patients with history of trabeculectomy presented with uncontrolled intraocular pressure (IOP) postoperatively. The first patient had a flat and vasularized bleb 10 weeks after the surgery, and the second subject developed encapsulated bleb 3 months postoperatively. Both patients were taken to the operating room and intraoperative optical coherence tomography (OCT) guided bleb needling was performed to restore aqueous egress into the subconjunctival space. Postoperatively, IOP of the operated eyes ranged 14-18 mmHg at week 6 and month 3...
October 2016: Journal of Ophthalmic & Vision Research
Quan V Hoang, Luis S Mendonca, Kara E Della Torre, Jesse J Jung, Angela J Tsuang, K Bailey Freund
PURPOSE: We assessed the frequency and predictive factors related to intraocular pressure (IOP) elevation in neovascular age-related macular degeneration (AMD) patients undergoing unilateral intravitreal ranibizumab and/or bevacizumab injections. DESIGN: Retrospective cohort study. PARTICIPANTS: Charts of 207 patients with neovascular AMD who presented to a single physician at a retinal referral practice over a 6-month period were retrospectively reviewed...
February 2012: Ophthalmology
D McG Taylor, A Lahiri, J K G Laitung
Inverted nipple is a relatively common aesthetic problem presenting to a plastic surgeon. Along with the functional problems; recurrent inflammation/infection and an inability to nurse, most patients seek intervention because of the abnormal appearance. Many different surgical techniques have been described, suggesting that no one technique is universally successful. Most techniques employ, either individually or in combination, methods to tighten the nipple base or the use of areolar dermal flaps to support the nipple...
December 2011: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
C Kesavachandran, M K Pathak, M Fareed, V Bihari, N Mathur, A K Srivastava
BACKGROUND: Shop keepers dealing with pesticides are exposed to multiple pesticides that include organophosphates, organochlorines, carbamates, pyrethroids. Hence an exploratory health study was conducted on shopkeepers selling pesticides in urban areas of Lucknow and Barabanki District, Uttar Pradesh, India. MATERIALS AND METHODS: Detailed information regarding socio-economic status, family history, personal habits and work practices were recorded for 20 subjects and controls by the investigator on a pre-tested questionnaire...
December 2009: Indian Journal of Occupational and Environmental Medicine
Saemundur J Oddsson, Tómas Gudbjartsson
Pulmonary sequestration (PS) is a rare disease where non-functioning lung tissue is separated from the normal bronchopulmonary tree and vasularized by an aberrant systemic artery. The origin of PS is not fully understood. Here we describe two unique cases of PS that support the hypothesis that PS is a congenital malformation rather than an acquired one. These are also the first Icelandic cases of PS reported.
March 2008: Læknablađiđ
Jerome D Cohen
BACKGROUND: Our understanding of the process leading to hypertension is allowing us to adopt principles of therapy that may be more beneficial for patients. OBJECTIVE: To review the physiology, vasular biology, and mechanisms of hypertension. SUMMARY: Hypertension, particularly in high-risk patients, is a result of loss of balance and the absence of the ability to vasodilate normally. The interaction between the endothelial cell and the smooth muscle cell is very important in this process...
June 2007: Journal of Managed Care Pharmacy: JMCP
T Peycru, N Biance, J P Avaro, P H Savoie, E Tardat, P Balandraud
Mesenteric trauma, i.e., injuries located in the bowel or organs supplied by the superior mesenteric artery, can be life-threatening. The incidence of these lesions is low. Most occur as result of blunt and penetrating abdominal trauma due mainly to gunshot wounds or road accidents. Management of these serious injuries can be challenging in the military field hospitals. The major problem in austere environment is the unavailabiity of computerized axial and other tools gene rally used for diagnosis. As an alternative to tomography diagnostic peritoneal lavage can be used with a high sensitivity for the detection of mesenteric trauma...
April 2006: Médecine Tropicale: Revue du Corps de Santé Colonial
Jacek Janica, Wojciech Serwatka, Jerzy Polaków, Andrzej Ustymowicz, Urszula Łebkowska, Kazimierz Kordecki, Jerzy Walecki, Piotr Polaków, Sławomir Dobrzycki
BACKGROUND: Contrast-enhanced, wide-band, phase inversion power Doppler sonography in the depiction of vasculature in hemangioma and focal nodular hyperplasia. MATERIAL/METHODS: Fifty-one patients with liver lesions (40 FNHs,37 hemangiomas) were prospectively evaluated with conventional, color, power Doppler sonography, tissue harmonic, phase-inversion sonography and helical CT. Levovist was the standard contrast agent used and all examinations were performed on Siemens SONOLINE Elegra equipped with Ensemble Contrast Imaging (ECI) software...
June 2004: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
A Di Blasi, A Boscaino, G De Dominicis, G Marino-Marsilia
The Authors present a case of Splenic Hamartoma. This is a rare unique complex vascular lesion of the spleen. This is also a recently reinterpreted lesion with some persistent confusion regarding its definition, histogenesis and classification. The patient is a young woman who following a check up with a raised erythrocyte sedimentation rate underwent abdominal sonography demonstrating an incidental slightly hypoechoic nodular splenic lesion. The pathologic study of the splenectomy specimen showed a large (10 cm) sharply demarcated mass...
June 2005: Pathologica
Ernst Michael Jung, Karl-Peter Jungius, Nikolaus Rupp, María Gallegos, Gunter Ritter, Markus Lenhart, Dirk-Andre Clevert, Reinhard Kubale
PURPOSE: To investigate the extent to which indeterminate lesions of the breast can be differentiated in the early and late phase after bolus injection of the ultrasound contrast medium Optison. MATERIALS AND METHODS: Fifty female patients (mean age: 49 years) with a altogether 53 preoperatively impalpable indeterminate breast tumors, 20 fibroadenomas and 33 carcinomas, were examined by B-mode imaging and contrast medium-enhanced ultrasound with power Doppler (three patients had multifocal carcinomas)...
2005: Clinical Hemorheology and Microcirculation
P Cogliati
Among the advantages of hemodiafiltration (HDF) cardiovascular stability seems the most popular. For several years the theory was that fluid infusion at a lower temperature induced similar effects to 'cool dialysis'. Due to the studies of Maggiore in 1982, we know that hemodialytic treatment per se induces in the majority of patients a rise in body temperature, on average 1.5-2 degrees C; the reasons for this phenomenon are unclear, even if theories developed in different trials take the following deputed to body cooling into account; an increase of the catabolism, linked to the bioincompatibility of the materials or to pyrogenic and cytokine-inducing substances, or a reduction in thermal scattering by the vasoconstriction of vasular districts such as skin and muscles...
January 2005: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
The present studies suggest that polymorphonuclear leukocytes (PMN's) are essential for the development of cardiovascular lesions in serum sickness. In the absence of PMN's, necrotic vascular lesions were never seen and endothelial proliferation in arteries was inhibited. Zones of fibrinoid deposits did not occur. By contrast, at least two-thirds of the control animals exhibited endothelial proliferation, and half had necrosis of arterial walls, usually with fibrinoid deposits. In arterial lesions that involved the intima and media, the internal elastic lamina was disrupted...
July 1, 1965: Journal of Experimental Medicine
C Liu, C Jiang, C Liu, P Liu, Y Hu
OBJECTIVE: To investigate the intervention of Fuzhenghuayu decoction on autocrine activation of hepatic stellate cell. METHODS: The drug serum containing Fuzhenghuayu decoction was collected from the normal rats, and cultured with activated hepatic stellate cells (HSC) in vitro. The conditional medium from the drug serum treated HSC was collected, and added to primarily cultured quiescent HSC. The primary cell proliferation was assayed by MTT colorometric test, and the contents of type I collagen and vasular endothelial growth factor (VEGF) in the medium were assayed with ELISA...
October 2001: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
J Chen, A Bierhaus, S Schiekofer, M Andrassy, B Chen, D M Stern, P P Nawroth
Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of angiogenesis, tumor growth and metastasis. In several models, TF expression mediates upregulation of the proangiogenic vasular endothelial growth factor (VEGF) that can directly act on endothelial cells to promote vessel formation. This occurs through ligand binding, activation of signaling cascades, signal transduction and alteration of growth factor expression and is mediated by both, coagulation-dependent and -independent pathways...
July 2001: Thrombosis and Haemostasis
J Green, S Assady, F Nakhoul, T Bick, P Jakobi, Z Abassi
The clinical features of preeclampsia have been traditionally ascribed to a generalized vascular endothelial cell dysfunction. The present study investigates the effect of sera from preeclamptic women and normal pregnancy on the metabolism of intracellular Ca(2+) concentration ([Ca(2+)](i)) in normal cultured vascular smooth muscle cells (VSMC). Sera were obtained from normotensive pregnant women (NTP) (n = 17), preeclamptic women (PE) (n = 15), pregnant women with chronic (essential) hypertension (pregnant EHT) (n = 8), non-pregnant women with essential hypertension (non-pregnant EHT) (n = 12), and age-matched non-pregnant normotensive women (NNP) (n = 18)...
July 2000: Journal of the American Society of Nephrology: JASN
K Tang, Y Lu, H Sheng
The experience on management of abnormal blood vessels in 128 cases of donor kidney during the tailoring operation was reported. The various techniques used for different types of abnormal arteries and veins, and the critical points which should be paid attention to have been discussed. It was concluded that the multiple renal arteries should be treated in a single renal artery and anastomosed with internal iliac artery or/and external iliac artery. The appropriate management given to abnormal renal blood vessels during the tailoring operation may shorten the warm ishemia time, ensure the renal blood supply, reduce the renal vasular complication, and promote the recovery of renal function...
July 1998: Chinese Journal of Reparative and Reconstructive Surgery
K Mayerhofer, A Obermair, G Windbichler, E Petru, A Kaider, L Hefler, K Czerwenka, S Leodolter, C Kainz
OBJECTIVE: The aim of this study was to evaluate the behavior of uterine leiomyosarcomas in relation to their clinical and pathologic features and to identify possible prognostic factors. METHODS: Seventy-one patients with histologically proven uterine leiomyosarcoma were included in the analysis. Leiomyosarcomas were defined as uterine smooth-muscle tumors with five or more mitoses per 10 high-power fields and cytologic atypia. Cox proportional hazards regression model was used to identify independent prognostic factors...
August 1999: Gynecologic Oncology
W Benzel, J Zenk, H Iro
BACKGROUND: Color-coded duplex sonography is being increasingly used in the head and neck as another method of diagnosis of, for example, stenosis of arteries or veins or of hemangioma. Moreover, it is of greatest interest in having the ability to differentiate benign from malignant tumors. Since the underlying type of tumor is directly responsible for the (operative) treatment recommended we have investigated histologically proven benign and malignant parotid tumors. PATIENTS: Thirty-six patients (20 women, 16 men, ages 32-66 years) with parotid tumors of unknown histology were examined by means of ultrasound and color-coded duplex sonography...
January 1995: HNO
S V Chemezov
In 43 test animals the state of the blood bed in the retrobulbar formations and the eyeball vasular tunic has been studied under venous congestion produced by ligation of the anterior vena cava (in dogs) and both external jugular veins (in rabbits). A complex of histological, histotopographic, morphometric and variation-statistical techniques has been used. The results obtained demonstrate that disturbances in the venous outflow in the anterior vena cava system produce certain responses in all parts of the retrotubular adipose tissue, of the eyeball muscles, of the optic nerve tunics, of the vascular tunic...
October 1984: Arkhiv Anatomii, Gistologii i émbriologii
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"