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Exclusive enteral nutrition

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https://www.readbyqxmd.com/read/28815649/systematic-review-with-meta-analysis-enteral-nutrition-therapy-for-the-induction-of-remission-in-paediatric-crohn-s-disease
#1
REVIEW
A Swaminath, A Feathers, A N Ananthakrishnan, L Falzon, S Li Ferry
BACKGROUND: Despite potential adverse-events in a paediatric population, corticosteroids are used to induce remission in paediatric Crohn's disease. Exclusive enteral nutrition also induces remission, but is infrequently used in the USA because corticosteroids are considered the superior therapy. New data have become available since the publication of the most recent meta-analysis in 2007. AIM: To see if current literature supports the use of EEN versus CS in paediatric populations...
August 16, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28791279/pneumocystis-jirovecii-pneumonia-in-pediatric-inflammatory-bowel-disease-a-case-report-and-literature-review
#2
Sally J Lawrence, Manish Sadarangani, Kevan Jacobson
Immunosuppressive therapy is a known risk factor for opportunistic infections. We report the first case of severe Pneumocystis jirovecii infection requiring intensive care in a pediatric patient with inflammatory bowel disease (IBD). The literature was reviewed and there were 92 reported cases of Pneumocystis pneumonia (PCP) in patients with IBD. Most sources were case reports and there was likely reporting bias toward patients receiving immunomodulators, anti-tumor necrosis factor (anti-TNF) therapy, and those who died...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28777338/effects-of-the-exclusive-enteral-nutrition-on-the-microbiota-profile-of-patients-with-crohn-s-disease-a-systematic-review
#3
REVIEW
Simona Gatti, Tiziana Galeazzi, Elisa Franceschini, Roberta Annibali, Veronica Albano, Anil Kumar Verma, Maria De Angelis, Maria Elena Lionetti, Carlo Catassi
The mechanisms behind the efficacy of exclusive enteral nutrition (EEN) in Crohn's disease (CD) remain poorly understood, despite the high rate of treatment response. Evidence accumulated in the last 20 years suggests that a positive shift of the disrupted microbiota is one of the treatment effects. The purpose of this study was to critically review and summarize data reporting the microbiological effects of EEN in patients with CD. Fourteen studies were considered in the review, overall involving 216 CD patients on EEN...
August 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28768295/exclusive-enteral-nutrition-for-inducing-remission-in-inflammatory-bowel-disease-in-paediatric-patients
#4
Amit Assa, Raanan Shamir
PURPOSE OF REVIEW: Enteral nutrition as a treatment for inflammatory bowel diseases is an ongoing area of interest. Even in the era of biologic agents, exclusive enteral nutrition (EEN) offers a unique, drug-free measure for induction of remission in luminal Crohn's disease. The purpose of this review is to discuss the role of EEN in the evolving therapeutic scheme for Crohn's disease, to report on new evidence for short and long-term efficacy and highlight findings on the mechanisms of the anti-inflammatory effects of EEN in light of current understanding of disease pathogenesis...
September 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28760114/assessing-selenium-manganese-and-iodine-status-in-pediatric-patients-receiving-parenteral-nutrition
#5
Jacob Clarke Johnsen, Susan Anne Reese, Mark Mackay, Collin R Anderson, Daniel Jackson, Irasema Libertad Paul
BACKGROUND: Pediatric patients who are receiving parenteral nutrition (PN) unsupplemented with trace minerals can become deficient. Due to shortages in trace mineral products and the 2004 American Society for Parenteral and Enteral Nutrition report stating that individualized trace element supplementation may be warranted, a review was conducted concerning the trace minerals selenium (Se), manganese (Mn), and iodine (I). METHOD: A retrospective review of pediatric patients receiving PN that contained Se and Mn was conducted to determine if a difference existed between them and patients receiving PN without Se and Mn...
August 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28731841/survey-of-nutrition-management-practices-in-centers-for-pediatric-intestinal-rehabilitation
#6
Anita M Nucci, Kipp Ellsworth, Austin Michalski, Emily Nagel, Jackie Wessel
BACKGROUND: Nutrition management of pediatric intestinal failure (IF) requires interdisciplinary coordination of parenteral nutrition (PN) and enteral nutrition (EN) support. Nutrition strategies used by specialists in pediatric intestinal rehabilitation to promote gut adaptation and manage complications have not been previously summarized. METHODS: A practice survey was distributed to members of the dietitian subgroup of the American Society for Parenteral and Enteral Nutrition Pediatric Intestinal Failure Section...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28719331/factors-associated-with-the-duration-of-moderate-to-severe-diarrhea-among-children-in-rural-western-kenya-enrolled-in-the-global-enteric-multicenter-study-2008-2012
#7
MULTICENTER STUDY
Katharine A Schilling, Richard Omore, Gordana Derado, Tracy Ayers, John B Ochieng, Tamer H Farag, Dilruba Nasrin, Sandra Panchalingam, James P Nataro, Karen L Kotloff, Myron M Levine, Joseph Oundo, Michelle B Parsons, Cheryl Bopp, Kayla Laserson, Christine E Stauber, Richard Rothenberg, Robert F Breiman, Ciara E O'Reilly, Eric D Mintz
Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28670231/japanese-physicians-attitudes-towards-enteral-nutrition-treatment-for-pediatric-patients-with-crohn-s-disease-a-questionnaire-survey
#8
Takashi Ishige, Takeshi Tomomasa, Hitoshi Tajiri, Atsushi Yoden
BACKGROUND/AIMS: Enteral nutrition (EN) is recommended for the treatment of pediatric Crohn's disease (CD) in Japan. However, the indications and treatment protocols for EN vary among hospitals. In the present study, we aimed to determine how EN was administered to pediatric patients and whether physicians followed treatment guidelines in their practices. METHODS: Two types of questionnaires were administered to 32 physicians who were involved in the treatment of pediatric CD...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28655159/two-distinct-metacommunities-characterize-the-gut-microbiota-in-crohn-s-disease-patients
#9
Qing He, Yuan Gao, Zhuye Jie, Xinlei Yu, Janne Marie Laursen, Liang Xiao, Ying Li, Lingling Li, Faming Zhang, Qiang Feng, Xiaoping Li, Jinghong Yu, Chuan Liu, Ping Lan, Ting Yan, Xin Liu, Xun Xu, Huanming Yang, Jian Wang, Lise Madsen, Susanne Brix, Jianping Wang, Karsten Kristiansen, Huijue Jia
Background: The inflammatory intestinal disorder Crohn's disease (CD) has become a health challenge worldwide. The gut microbiota closely interacts with the host immune system, but its functional impact in CD is unclear. Except for studies on a small number of CD patients, analyses of the gut microbiota in CD have used 16S rDNA amplicon sequencing. Here we employed metagenomic shotgun sequencing to provide a detailed characterization of the compositional and functional features of the CD microbiota, comprising also unannotated bacteria, and investigated its modulation by exclusive enteral nutrition (EEN)...
June 26, 2017: GigaScience
https://www.readbyqxmd.com/read/28598298/efficacy-of-exclusive-enteral-nutrition-in-complicated-crohn-s-disease
#10
Qingfan Yang, Xiang Gao, Huiping Chen, Miao Li, Xiaojian Wu, Min Zhi, Ping Lan, Pinjin Hu
AIM: To investigate the efficacy of exclusive enteral nutrition (EEN) in induction of remission in adult active Crohn's disease (CD) complicated with intestinal fistula/abdominal abscess or inflammatory intestinal stricture. METHOD: Patients diagnosed with active CD with complications were recruited between July 2013 and July 2015. Patients were offered EEN for 12 weeks. Patients with abscess received antibiotic treatment with or without percutaneous drainage. Clinical variables were recorded (ClinicalTrials...
September 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28597827/inflammatory-bowel-disease-in-childhood-and-adolescence
#11
Jan Däbritz, Patrick Gerner, Axel Enninger, Martin Claßen, Michael Radke
BACKGROUND: The incidence of inflammatory bowel disease (IBD) in childhood and adolescence is 5-11 cases per 100 000 persons per year, corresponding to a new diagnosis of IBD in 800-1470 patients in Germany each year. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed, including guidelines from Germany and abroad. RESULTS: Children and adolescents with IBD often have extensive involvement and an aggressive course of disease...
May 12, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28583886/risk-factors-and-clinical-outcomes-for-carbapenem-resistant-gram-negative-late-onset-sepsis-in-a-neonatal-intensive-care-unit
#12
I Nour, H E Eldegla, N Nasef, B Shouman, H Abdel-Hady, A E Shabaan
BACKGROUND: Carbapenem-resistant (CR), Gram-negative (GN), late-onset sepsis (LOS) is a serious threat in the neonatal intensive care unit (NICU). AIM: To assess the prevalence of CR-GN-LOS in NICU patients and to identify the risk factors and outcomes associated with its acquisition. METHODS: Neonates with carbapenem-susceptible (CS)-GN-LOS were compared with those with CR-GN-LOS in a two-year observational study. FINDINGS: A total of 158 patients had GN-LOS; 100 infants had CS-GN-LOS and 58 infants had CR-GN-LOS...
June 3, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28575325/exclusive-enteral-nutrition-therapy-in-pediatric-crohn-s-disease-results-in-long-term-avoidance-of-corticosteroids-results-of-a-propensity-score-matched-cohort-analysis
#13
Jessica Connors, Sana Basseri, Amy Grant, Nick Giffin, Gamal Mahdi, Angela Noble, Mohsin Rashid, Anthony Otley, Johan Van Limbergen
Background & Aims: Exclusive enteral nutrition (EEN) is recommended as first-line induction therapy for pediatric Crohn's disease (CD) although corticosteroids (CS) are still used commonly. Our aim was to compare short- and long-term disease outcomes of pediatric CD patients initially managed with either EEN or CS. Methods: Medical records of newly-diagnosed pediatric CD patients treated with EEN or CS as induction therapy were retrospectively reviewed. To minimize selection bias inherent in observational cohort studies, propensity analysis was carried out...
May 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28567370/maintenance-of-remission-with-partial-enteral-nutrition-therapy-in-pediatric-crohn-s-disease-a-retrospective-study
#14
Jacqueline M Schulman, Liat Pritzker, Ron Shaoul
BACKGROUND: Partial enteral nutrition (PEN) may be helpful for the maintenance of remission in pediatric Crohn's disease patients. AIMS: To evaluate the efficacy of PEN treatment for preventing clinical relapse. METHODS: We retrospectively assessed 42 pediatric Crohn's disease patients who entered clinical remission on 4-12 weeks of exclusive enteral nutrition (EEN) and were maintained on PEN as a supplementary diet. We evaluated the efficacy of the treatment at different time points using the weighted Pediatric Crohn Disease Activity Index (wPCDAI), Physician Global Assessment, laboratory parameters, and growth of each patient...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28551707/nutritional-therapy-in-very-early-onset-inflammatory-bowel-disease-a-case-report
#15
Talya L Miller, Dale Lee, Mathew Giefer, Ghassan Wahbeh, David L Suskind
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract caused by a dysregulated immune response to the fecal microbiota. Very early-onset inflammatory bowel disease (VEO-IBD) refers to a subgroup of pediatric patients with IBD diagnosed before 6 years of age. This subgroup is often characterized by increased severity, aggressive progression, strong family history of IBD, and often poor response to conventional treatments. Nutritional therapies have been utilized to treat IBD, but their role in VEO-IBD is unclear...
August 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28538523/the-effect-of-maternal-milk-on-tolerance-and-growth-in-premature-infants-a-hypothesis-generating-study
#16
Jacomine E Hogewind-Schoonenboom, Lyanne W W Rövekamp-Abels, Daphne P M de Wijs-Meijler, Margaux D Maduro, Marijke C Jansen-van der Weide, Johannes B van Goudoever, Jessie M Hulst
OBJECTIVE: Early growth rates and feeding advancement rates of preterm infants are thought to influence later health. Feeding advancement is often difficult because of feeding intolerance. Exclusive human milk feeding improves tolerance, but can result in a lower weight gain rate. The addition of human milk fortifier has advantages for growth, but there are concerns that it may nullify the beneficial effect of human milk on tolerance. Therefore, the objective of the present study was to evaluate the relation between the amount of fortified human milk or formula and feeding tolerance and growth in preterm infants...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28531392/a-randomised-controlled-feasibility-and-proof-of-concept-trial-in-delayed%C3%A2-gastric-emptying-when-metoclopramide-fails-we-should-revisit%C3%A2-nasointestinal-feeding-versus-dual-prokinetic-treatment-achieving-goal-nutrition-in-critical-illness-and-delayed-gastric
#17
Stephen J Taylor, Kaylee Allan, Helen McWilliam, Alex Manara, Jules Brown, Rosemary Greenwood, Deirdre Toher
BACKGROUND & AIMS: Delayed gastric emptying (DGE) commonly limits the use of enteral nutrition (EN) and may increase ventilator-associated pneumonia. Nasointestinal feeding has not been tested against dual prokinetic treatment (Metoclopramide and Erythromycin) in DGE refractory to metoclopramide. This trial tests the feasibility of recruiting this 'treatment-failed' population and the proof of concept that nasointestinal (NI) feeding can increase the amount of feed tolerated (% goal) when compared to nasogastric (NG) feeding plus metoclopramide and erythromycin treatment...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28525622/dietary-therapy-with-the-crohn-s-disease-exclusion-diet-is-a-successful-strategy-for-induction-of-remission-in-children-and-adults-failing-biological-therapy
#18
Rotem Sigall Boneh, Chen Sarbagili-Shabat, Heinit Yanai, Irit Chermesh, Sivan Ben Avraham, Mona Boaz, Arie Levine
Background: Loss of response (LoR) to biologics in Crohn's disease (CD) is a significant clinical problem. Dietary therapy as a treatment strategy in this setting has not been previously reported. We report the use of dietary strategies using enteral nutrition coupled with the Crohn's Disease Exclusion Diet (CDED) for LoR to infliximab or adalimumab as a single center experience. Methods: Patients with LoR to a biologic despite dose escalation or combination therapy were treated with partial enteral nutrition (PEN) by a polymeric formula and the CDED for 12 weeks...
May 19, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28507982/the-role-of-carrageenan-and-carboxymethylcellulose-in-the-development-of-intestinal-inflammation
#19
REVIEW
John Vincent Martino, Johan Van Limbergen, Leah E Cahill
Although the exact pathophysiology remains unknown, the development of inflammatory bowel disease (IBD) is influenced by the interplay between genetics, the immune system, and environmental factors such as diet. The commonly used food additives, carrageenan and carboxymethylcellulose (CMC), are used to develop intestinal inflammation in animal models. These food additives are excluded from current dietary approaches to induce disease remission in Crohn's disease such as exclusive enteral nutrition (EEN) using a polymeric formula...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28475294/refractory-cytopenias-secondary-to-copper-deficiency-in-children-receiving-exclusive-jejunal-nutrition
#20
Amanda E Jacobson, Samir B Kahwash, Anjulika Chawla
Copper deficiency is a known cause of anemia and neutropenia that is easily remedied with copper supplementation. Copper is primarily absorbed in the stomach and proximal duodenum, so patients receiving enteral nutrition via methods that bypass this critical region may be at increased risk for copper deficiency. In pediatrics, postpyloric enteral feeding is increasingly utilized to overcome problems related to aspiration, severe reflux, poor gastric motility, and gastric outlet obstruction. However, little is known about the prevalence of copper deficiency in this population...
May 5, 2017: Pediatric Blood & Cancer
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