Baris Boyraz, Ryosuke Tajiri, Rofieda R Alwaqfi, Arnaud Da Cruz Paula, Qiqi Ye, G Petur Nielsen, Yin P Hung, Esther Oliva, Britta Weigelt, Masanori Hisaoka, Jaclyn C Watkins
Angiomyofibroblastoma (AMF), a rare benign vulvovaginal mesenchymal tumour, poses a diagnostic challenge due to histologic and immunohistochemical overlap with other vulvar mesenchymal tumours. Recently, MTG1-CYP2E1 fusion transcripts were reported in 5/5 AMFs; no other genetic alterations have been described to date. Herein, we sought to investigate the frequency of the MTG1-CYP2E1 fusion and the presence of other potential genetic alterations in a cohort of AMFs (n = 7, patient age range: 28-49 years)...
December 2022: Histopathology