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https://www.readbyqxmd.com/read/28102527/teratoma-of-the-sellar-region-a-case-report
#1
Wolfgang Saeger, Azadeh Ebrahimi, Rudi Beschorner, Hildegard Spital, Jürgen Honegger, Waldemar Wilczak
The case report describes a teratoma of the sellar region with a gland forming and an immature, relatively clear undifferentiated component without signs of anaplasia. Both components express TTF-1 indicating their presumable origin in the neurohypophysis as part of the circumventricular organs. The differential diagnosis includes pituitary adenoma and spindle cell oncocytoma with inclusion of Rathke's cleft cyst, pituitary blastoma, yolk sac tumor, and other germ cell tumors. The prognosis is the same as in the immature teratomas in the gonads, specifically unclear...
January 19, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28095383/evaluation-of-plasmatic-kisspetin-10-as-a-biomarker-for-malignancy-and-subtype-differentiation-in-small-renal-tumours
#2
Marcus Horstmann, Felix Krause, Daniel Steinbach, Lars Twelker, Marc-Oliver Grimm
OBJECTIVE: To evaluate Kisspeptin-10 (Kiss-10) in patients with small renal tumours (SRTs) and controls. MATERIAL AND METHODS: Kiss-10 was measured in preoperative plasma samples in a cohort of 143 patients with unilateral renal tumours smaller than or equal to 4 cm and 40 age-matched controls by a competitive ELISA test kit. The cohort of patients included 56 patients with clear cell renal cell carcinoma (ccRCC), 43 with papillary RCC (pRCC), 12 with chromophobe RCC (chRCC) and 32 with oncocytomas...
January 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28093347/a-novel-invasive-related-biomarker-in-three-subtypes-of-non-functioning-pituitary-adenomas
#3
Yong Chen, Hong-Li Chuan, Sheng-Yuan Yu, Chu-Zhong Li, Zhe-Bao Wu, Gui-Lin Li, Ya-Zhuo Zhang
OBJECTIVES: To identify biomarkers key to invasiveness of the three subtypes of non-functioning pituitary adenomas (NFPAs) and provide a guidance for therapeutic decision-making and identification of potential adjuvant drugs. METHODS: Fifty NFPAs tumor tissues obtained from transsphenoidal surgery were used in the study. Three invasive NFPAs and four non-invasive NFPAs were used for gene expression microarray analyses; Additionally, there are five invasive NFPAs and four non-invasive NFPAs used for proteomic analyses...
January 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28092140/a-systematic-review-of-sinonasal-oncocytomas-and-oncocytic-carcinomas-diagnosis-management-and-technical-considerations
#4
REVIEW
Zerina Hodzic, Nicholas R Rowan, Ryota Kashiwazaki, Thomas J Willson, Eric W Wang, Stella E Lee
BACKGROUND: Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS: A systematic literature review was performed using PubMed and Ovid databases. The data obtained from published articles with sinonasal oncocytoma/oncocytic carcinoma as the primary diagnosis included patient demographics, presentation, radiographic and histologic findings, management, and recurrence rates...
January 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28074380/usefulness-of-diffusion-weighted-mr-imaging-for-differentiating-between-warthin-s-tumor-and-oncocytoma-of-the-parotid-gland
#5
Hiroki Kato, Keita Fujimoto, Masayuki Matsuo, Keisuke Mizuta, Mitsuhiro Aoki
PURPOSE: To assess the efficacy of diffusion-weighted (DW) MR imaging for differentiating between Warthin's tumor and oncocytoma of the parotid gland. METHODS: Forty-five histopathologically confirmed parotid gland tumors (41 Warthin's tumors and 4 oncocytomas) were examined by MR imaging including DW imaging. (18)F-fluorodeoxyglucose PET/CT was also performed in 9 Warthin's tumors and 3 oncocytomas. We retrospectively reviewed the images and compared the MR signal intensities, apparent diffusion coefficients (ADCs), and maximum standardized uptake values (SUVmax) of the solid components between the two pathologies...
January 10, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28072625/evaluation-of-a-large-renal-mass-using-99mtc-mibi-spect-ct-in-a-patient-with-chronic-kidney-disease
#6
Steven P Rowe, Michael A Gorin, Mehrbod S Javadi, Mohamad E Allaf
The differentiation of benign and indolent renal masses from aggressive tumor histologies cannot be reliably performed by CT or MRI. Additionally, renal mass biopsy risks complications and has a nondiagnostic rate of 10% to 20%. Tc-MIBI SPECT/CT has been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chormophobe tumors from other more aggressive renal tumor types. We present the case of an 84-year-old man with chronic kidney disease and an 11.2-cm renal mass...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28068796/partial-nephrectomy-for-presumed-renal-cell-carcinoma-incidence-predictors-and-perioperative-outcomes-of-benign-lesions
#7
Tyler Marques Bauman, Aaron Potretzke, Alec J Wright, Brent Alexander Knight, Joel M Vetter, Robert S Figenshau
BACKGROUND: The aim of this study was to investigate the incidence of benign histology after partial nephrectomy (PN) in patients with presumed malignancy from preoperative imaging. Further, preoperative predictors of benign lesions and perioperative outcomes were also assessed. METHODS: A series of patients undergoing PN for renal masses was identified using a prospectively maintained database. Patients were excluded for known genetic conditions, if more than one renal mass was resected, or if standard preoperative imaging was not suspicious for RCC...
January 9, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28063355/orbital-oncocytoma-evaluation-with-dynamic-contrast-enhanced-magnetic-resonance-imaging-using-a-time-signal-intensity-curve-and-positive-enhancement-integral-images
#8
Nutchawan Jittapiromsak, Ping Hou, Michelle D Williams, T Linda Chi
Oncocytomas, which are benign epithelial tumors filled with abundant mitochondria, arise from ductal cells. Oncocytomas rarely occur in the orbit. We present a case of pathologically proven orbital oncocytoma of the lacrimal gland studied by dynamic contrast-enhanced magnetic resonance imaging (DCE MRI). DCE MRI has potential as an adjunct to conventional MRI in the differential diagnosis and tumor margin delineation of orbital oncocytoma. Simple assessments of the time-signal intensity curve, semiquantitative parameters, and post-processing positive enhancement integral images should be considered in the evaluation of orbital masses found on MRI...
December 6, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/28061437/keap1-nrf2-pathway-in-kidney-cancer-frequent-methylation-of-keap1-gene-promoter-in-clear-renal-cell-carcinoma
#9
Federico Pio Fabrizio, Manuela Costantini, Massimiliano Copetti, Annamaria la Torre, Angelo Sparaneo, Andrea Fontana, Luana Poeta, Michele Gallucci, Steno Sentinelli, Paolo Graziano, Paola Parente, Vincenzo Pompeo, Laura De Salvo, Giuseppe Simone, Rocco Papalia, Francesco Picardo, Teresa Balsamo, Gerardo Paolo Flammia, Domenico Trombetta, Angela Pantalone, Klaas Kok, Ferronika Paranita, Lucia Anna Muscarella, Vito Michele Fazio
The Keap1/Nrf2 pathway is a master regulator of the cellular redox state through the induction of several antioxidant defence genes implicated in chemotherapeutic drugs resistance of tumor cells. An increasing body of evidence supports a key role for Keap1/Nrf2 pathway in kidney diseases and renal cell carcinoma (RCC), but data concerning the molecular basis and the clinical effect of its deregulation remain incomplete.Here we present a molecular profiling of the KEAP1 and NFE2L2 genes in five different Renal Cell Carcinoma histotypes by analysing 89 tumor/normal paired tissues (clear cell Renal Carcinoma, ccRCCs; Oncocytomas; Papillary Renal Cell Carcinoma Type 1, PRCC1; Papillary Renal Cell Carcinoma Type 2, PRCC2; and Chromophobe Cell Carcinoma)...
4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28058773/surgical-histopathology-for-suspected-oncocytoma-on-renal-mass-biopsy-a-systematic-review-and-meta-analysis
#10
REVIEW
Hiten D Patel, Sasha C Druskin, Steven P Rowe, Phillip M Pierorazio, Michael A Gorin, Mohamad E Allaf
OBJECTIVE: To estimate the proportion of oncocytic renal neoplasms diagnosed on renal mass biopsy (RMB) confirmed on surgical pathology. MATERIALS AND METHODS: A systematic review of MEDLINE, Embase, and the Cochrane databases (1997-July 1, 2016) was conducted to quantify all cases of reported oncocytic renal neoplasms on RMB suggestive of an oncocytoma. In addition, institutional data was assessed to identify additional cases. Concordance with surgical histopathology (positive predictive value) was evaluated for patients undergoing surgery by performing a meta-analysis...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28048071/su-f-r-39-effects-of-radiation-dose-reduction-on-renal-cell-carcinoma-discrimination-using-multi-phasic-ct-imaging
#11
M Wahi-Anwar, S Young, P Lo, S Raman, H Kim, M Brown, M McNitt-Gray, H Coy, D Ashen-Garry, E Pace-Soler
PURPOSE: A method to discriminate different types of renal cell carcinoma (RCC) was developed using attenuation values observed in multiphasic contrast-enhanced CT. This work evaluates the sensitivity of this RCC discrimination task at different CT radiation dose levels. METHODS: We selected 5 cases of kidney lesion patients who had undergone four-phase CT scans covering the abdomen to the lilac crest. Through an IRB-approved study, the scans were conducted on 64-slice CT scanners (Definition AS/Definition Flash, Siemens Healthcare) using automatic tube-current modulation (TCM)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035705/a-rare-case-of-cutaneous-oncocytic-hidradenoma
#12
Shivani P Reddy, Kim Chong, David S Cassarino
Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Oncocytomas, or tumors composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. Oncocytic metaplasia has only been rarely reported in various cutaneous neoplasms. We report a case of an elderly male presenting with a 5 millimeter erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based adnexal tumor with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged, bland-appearing epithelioid cells...
December 30, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28024966/office-based-ultrasound-guided-renal-core-biopsy-is-safe-and-efficacious-in-the-management-of-small-renal-masses
#13
Chirag N Dave, Brian Seifman, Avinash Chennamsetty, Rene Frontera, Kassem Faraj, Ryan Nelson, Colleen Lucido, Edward W Schervish
OBJECTIVE: To evaluate the safety and efficacy of ultrasound (US)-guided percutaneous renal mass biopsy (RMB) performed in the office setting by urologists. MATERIALS AND METHODS: This is a retrospective study involving patients who underwent office-based US-guided percutaneous RMB between April 2010 and October 2015. Baseline vital signs and US were performed prior to the procedure. Patients were then observed for 1 hour after the procedure and repeat vital signs and US were performed...
December 23, 2016: Urology
https://www.readbyqxmd.com/read/27979743/oncocytoma-as-a-growing-fdg-avid-adrenal-mass-on-serial-18-f-fdg-pet-ct-imaging-a-potential-pitfall-in-oncological-evaluation
#14
L Gilardi, M Vadrucci, S Pirola, C M Grana
No abstract text is available yet for this article.
December 12, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27959744/is-multiparametric-mri-useful-for-differentiating-oncocytomas-from-chromophobe-renal-cell-carcinomas
#15
Chloe Galmiche, Jean-Christophe Bernhard, Mokrane Yacoub, Alain Ravaud, Nicolas Grenier, François Cornelis
OBJECTIVE: The purpose of this study was to retrospectively evaluate the diagnostic accuracy of multiparametric MRI to differentiate oncocytoma from chromophobe renal cell carcinoma (RCC). MATERIALS AND METHODS: In this retrospective study, 26 histologically confirmed oncocytomas and 16 chromophobe RCCs that underwent full MRI examination were identified in 42 patients (25 men and 17 women) over a 6-year period. Demographic data were recorded. Double-echo chemical-shift, dynamic contrast-enhanced T1- and T2-weighted images, and apparent diffusion coefficient (ADC) maps were reviewed independently by two radiologists blinded to pathologic results...
December 13, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27931799/oncocytic-papillary-renal-cell-carcinoma-a-clinicopathological-and-genetic-analysis-and-indolent-clinical-course-in-14-cases
#16
Guiyan Han, Wenjuan Yu, Jing Chu, Yan Liu, Yanxia Jiang, Yujun Li, Wei Zhang
A sort of PRCC with distinct eosinophilic cytoplasm named Oncocytic Papillary Renal Cell Carcinoma (OPRCC) has been increasingly attracting the attention of researchers recently. However, owing to the rarity of OPRCC, the clinicopathological and genetic features of the tumor have still not been well elucidated and whether it should be regarded as an independent subtype of PRCC remains controversial. Herein, a cohort of 14 OPRCCs was studied with the aim of revealing the distinct clinicopathological features, facilitating the classification and correct diagnosis of OPRCC...
January 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27929599/surgical-management-of-parapharyngeal-space-tumors-the-role-of-cervical-and-lateral-skull-base-approaches
#17
Arturo Mario Poletti, Siba P Dubey, Giovanni Colombo, Giovanni Cugini
We conducted a retrospective study to analyze the role of the cervical and lateral skull base approaches in the surgical excision of parapharyngeal space (PPS) tumors. Our study population was made up of 34 patients-15 males and 19 females, aged 13 to 73 years (mean: 50.6)-who had presented to us with a PPS tumor during a 9-year period. The 34 cases included 23 benign tumors and 11 malignancies. The 23 benign tumors consisted of 11 pleomorphic adenomas, 5 schwannomas, 2 paragangliomas, 2 Warthin tumors, 1 oncocytoma, 1 hamartoma, and 1 osteochondroma...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27927758/mitochondrial-aging-is-there-a-mitochondrial-clock
#18
Dmitry B Zorov, Vasily A Popkov, Ljubava D Zorova, Ivan A Vorobjev, Irina B Pevzner, Denis N Silachev, Savva D Zorov, Stanislovas S Jankauskas, Valentina A Babenko, Egor Y Plotnikov
Fragmentation (fission) of mitochondria, occurring in response to oxidative challenge, leads to heterogeneity in the mitochondrial population. It is assumed that fission provides a way to segregate mitochondrial content between the "young" and "old" phenotype, with the formation of mitochondrial "garbage," which later will be disposed. Fidelity of this process is the basis of mitochondrial homeostasis, which is disrupted in pathological conditions and aging. The asymmetry of the mitochondrial fission is similar to that of their evolutionary ancestors, bacteria, which also undergo an aging process...
December 7, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27927654/expression-of-sodium-dependent-dicarboxylate-transporter-1-nadc1-slc13a2-in-normal-and-neoplastic-human-kidney
#19
Hyun-Wook Lee, Mary E Handlogten, Gunars Osis, William L Clapp, Dara N Wakefield, Jill W Verlander, I David Weiner
Regulated dicarboxylate transport is critical for acid-base homeostasis, prevention of calcium nephrolithiasis, regulation of collecting duct sodium chloride transport and the regulation of blood pressure. Although luminal dicarboxylate reabsorption via NaDC1 (SLC13A2) is believed to be the primary mechanism regulating renal dicarboxylate transport, the specific localization of NaDC1 in the human kidney is currently unknown. This study's purpose was to determine NaDC1's expression in normal and neoplastic human kidneys...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27906674/nuclear-localization-of-the-ck2%C3%AE-subunit-correlates-with-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#20
Maj Rabjerg, Barbara Guerra, Aida Oliván-Viguera, Minne Line Nedergaard Mikkelsen, Ralf Köhler, Olaf-Georg Issinger, Niels Marcussen
Protein kinase CK2α, one of the two catalytic isoforms of the protein kinase CK2 has been shown to contribute to tumor development, tumor proliferation and suppression of apoptosis in various malignancies. We conducted this study to investigate CK2 expression in different subtypes of Renal Cell Carcinoma (RCC) and in the benign oncocytoma. qRT-PCR, immunohistochemistry and Western blot analyses revealed that CK2α expression was significantly increased at the mRNA and protein levels in clear cell RCC (ccRCC)...
November 29, 2016: Oncotarget
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