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https://www.readbyqxmd.com/read/28631277/spindle-cell-oncocytoma-of-adenohypophysis-review-of-literature-and-report-of-another-recurrent-case
#1
Akash Sali, Sridhar Epari, Chandralekha Tampi, Atul Goel
Spindle cell oncocytoma (SCO) of adenohypophysis was first described in 2002 by Roncaroli et al. as a new entity in the tumors originating from adenohypophysis. It was subsequently recognized as a distinct entity in the 2007 WHO classification of CNS tumors and retained in the current updated classification. In contrast to that suggested by the original authors, this tumor does have a potential for recurrence as first described by Kloub et al. and later with many such case reports. This tumor can be confused with other sellar tumors like pituicytomas and pituitary adenoma, both radiologically and histopathologically...
June 19, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28631081/diffusion-weighted-imaging-versus-contrast-enhanced-mr-imaging-for-the-differentiation-of-renal-oncocytomas-and-chromophobe-renal-cell-carcinomas
#2
Yan Zhong, Haiyi Wang, Yanguang Shen, Aitao Guo, Jia Wang, Suhai Kang, Lu Ma, Jingjing Pan, Huiyi Ye
OBJECTIVES: To compare the performance of diffusion-weighted imaging (DWI) with that of contrast-enhanced MRI in differentiating renal oncocytomas from chromophobe renal cell carcinomas (RCCs). METHODS: We recruited 48 patients with histopathologically confirmed renal oncocytomas (n=16) and chromophobe RCCs (n=32). All patients underwent preoperative DWI and contrast-enhanced MRI. Apparent diffusion coefficient (ADC) and signal intensity were measured in each patient...
June 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28612665/granular-cell-tumor-of-the-neurohypophysis-with-tfe-3-expression-a-rare-case-report
#3
Guang-Zhi Yang, Jing Li
Granular cell tumor (GCT) rarely involves the central nervous system, and fewer than 100 cases have been reported in English literatures. We herein report a case of a 36-year-old Chinese man with GCT of the neurohypophysis. Magnetic resonance imaging showed one mass located in the hypophysis with heterogeneous contrast enhancement. Pathological examination showed a neoplasm comprising densely packed polygonal cells of ample cytoplasm with abundant eosinophilic granules inside. The nuclei were small with inconspicuous nucleoli and yet without any mitoses...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28600877/stepwise-algorithm-using-computed-tomography-and-magnetic-resonance-imaging-for-diagnosis-of-fat-poor-angiomyolipoma-in-small-renal-masses-development-and-external-validation
#4
Hajime Tanaka, Yasuhisa Fujii, Hiroshi Tanaka, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Sho Uehara, Noboru Numao, Takeshi Yuasa, Shinya Yamamoto, Hitoshi Masuda, Junji Yonese, Kazunori Kihara
OBJECTIVES: To develop a stepwise diagnostic algorithm for fat-poor angiomyolipoma in small renal masses. METHODS: Two cohorts of small renal masses <4 cm without an apparent fat component that was pathologically diagnosed were included: 153 cases (18 fat-poor angiomyolipomas/135 renal cell carcinomas) for model development and 71 cases (seven fat-poor angiomyolipomas/59 renal cell carcinomas/5 oncocytomas) for validation. Dynamic contrast-enhanced computed tomography, magnetic resonance imaging and clinical findings were analyzed...
June 10, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28592361/ct-imaging-of-solid-renal-masses-pitfalls-and-solutions
#5
REVIEW
S Krishna, C A Murray, M D McInnes, R Chatelain, M Siddaiah, O Al-Dandan, S Narayanasamy, N Schieda
Computed tomography (CT) remains the first-line imaging test for the characterisation of renal masses; however, CT has inherent limitations, which if unrecognised, may result in errors. The purpose of this manuscript is to present 10 pitfalls in the CT evaluation of solid renal masses. Thin section non-contrast enhanced CT (NECT) is required to confirm the presence of macroscopic fat and diagnosis of angiomyolipoma (AML). Renal cell carcinoma (RCC) can mimic renal cysts at NECT when measuring <20 HU, but are usually heterogeneous with irregular margins...
June 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28591289/oncocytoma-of-the-lacrimal-gland-a-case-report
#6
Eduardo Muniz Fenelon, Ivelise Theresa Balby, Nathália Teles das Neves, Florêncio Figueiredo, Eliza Carla Barros Duarte, Patrick Frensel Tzelikis
Here we describe a rare case of a benign tumor in the lacrimal gland of a healthy 4-year-old girl. Mild proptosis was the only abnormality observed on clinical examination. Magnetic resonance imaging of the right orbit revealed an oval, solid, well-circumscribed, homogeneous mass extending from the lacrimal gland and measuring 2.5 × 2.3 × 1.7 cm without any evidence of invasion into adjacent bones. The lesion was surgically excised and histological analyses defined the diagnosis of oncocytoma of the lacrimal gland...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28551171/remote-development-of-tumor-to-tumor-metastasis-of-breast-adenocarcinoma-in-a-renal-oncocytoma
#7
Daniel P Bitner, Matt B Clements, Helen P Cathro, Ayman Mithqal, Noah S Schenkman
Tumor-to-tumor metastasis (TTM) is a rare phenomenon where a focus of distinct metastatic disease is discovered with a second primary tumor. While renal cell carcinoma is the most frequent recipient of metastatic tumor cells, oncocytomas have also previously been described. We present the case of a patient with incidentally detected mammary adenocarcinoma within an oncocytoma 16 years following primary treatment. The mass was treated with partial nephrectomy, with the surgical pathology specimen showing clear delineation of the pleomorphic lobular carcinoma and oncocytoma cells...
May 24, 2017: Urology
https://www.readbyqxmd.com/read/28528853/sarcomatoid-renal-cell-carcinoma-and-collecting-duct-carcinoma-discrimination-from-common-renal-cell-carcinoma-subtypes-and-benign-rcc-mimics-on-multiphasic-mdct
#8
Jonathan R Young, Jocelyn A Young, Daniel J A Margolis, Steven Sauk, James Sayre, Allan J Pantuck, Steven S Raman
RATIONALE AND OBJECTIVES: To investigate whether imaging features on multiphasic multidetector computed tomography (MDCT) can help discriminate sarcomatoid renal cell carcinoma (RCC) and collecting duct carcinoma (CDC) from other solid renal masses. MATERIALS AND METHODS: With institutional review board approval for this HIPAA-compliant study, we derived a cohort of 7 sarcomatoid RCCs, 4 CDCs, 165 clear cell RCCs, 56 papillary RCCs, 22 chromophobe RCCs, 49 oncocytomas, and 16 lipid-poor angiomyolipomas with preoperative multiphasic MDCT with up to four phases (unenhanced, corticomedullary, nephrographic, and excretory)...
May 18, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28506049/-laparoscopic-non-ischemic-partial-nephrectomy-using-a-microwave-tissue-coagulator-a-single-institutional-study
#9
Shinji Fukui, Yusuke Iemura, Yoshiaki Matsumura, Yoriaki Kagebayashi, Shoji Samma
We retrospectively investigated the surgical outcomes of renal cell carcinoma (RCC), perioperative complications, and residual renal function in patients receiving laparoscopic non-ischemic partial nephrectomy using a microwave tissue coagulator (MTC). Between January 2002 and December 2015, laparoscopic non-ischemic partial nephrectomy using MTC was performed in 49 patients. The histological diagnosis was RCC in 38 patients, angiomyolipoma in 4, oncocytoma in 2, and others in 5. A histologicallyproven positive surgical margin was observed in 1 (2...
April 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28491452/renal-oncocytoma-in-a-cat-with-chronic-renal-failure
#10
Sora Lee, Hyun-Ji Choi, Han-Byul Lee, Sung-Min Jo, Ji-Hye Mun, Woo-Chan Son
CASE SUMMARY: A 9-year-old male neutered domestic shorthair cat presented with anorexia. Ultrasonography showed an irregularly shaped hypoechoic mass in the cranial pole of the right kidney. Ultrasound-guided fine-needle aspiration of the renal mass was performed. Cytology revealed moderate cellularity smears composed of epithelial cell clusters, which consisted of an exclusive population of oncocytic cells seen in sheets and papillary clusters along with abundant single cells. A moderate-to-abundant amount of densely stained granular cytoplasm with round nuclei and indistinct nucleoli was seen...
January 2017: JFMS open reports
https://www.readbyqxmd.com/read/28477311/update-on-adrenal-tumours-in-2017-world-health-organization-who-of-endocrine-tumours
#11
REVIEW
Alfred King-Yin Lam
The fourth edition of the World Health Organization (WHO) classification of endocrine tumours contains substantial new findings for the adrenal tumours. The tumours are presented in two chapters labelled as "Tumours of the adrenal cortex" and "Tumours of the adrenal medulla and extra-adrenal paraganglia." Tumours of the adrenal cortex are classified as cortical carcinoma, cortical adenoma, sex cord stromal tumours, adenomatoid tumour, mesenchymal and stromal tumours (myelolipoma and schwannoma), haematological tumours, and secondary tumours...
May 6, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28470573/bsnd-is-a-novel-immunohistochemical-marker-for-oncocytic-salivary-gland-tumors
#12
Kazuya Shinmura, Hisami Kato, Yuichi Kawanishi, Takaharu Kamo, Yusuke Inoue, Katsuhiro Yoshimura, Kenta Sugiyama, Kiyoshi Misawa, Seiji Hosokawa, Hiroyuki Mineta, Haruhiko Sugimura
BSND protein, which is involved in chloride transport, is expressed in normal kidney and the inner ear and is known as an immunohistochemical marker for chromophobe renal cell carcinoma (RCC) and renal oncocytoma; however, other organs and tumor types exhibiting BSND expression have not yet been reported. In this study, we investigated the expression of BSND using data from the Cancer Genome Atlas (TCGA) database and by performing immunohistochemical analyses. As a result, we found that BSND was also expressed in the striated duct cells of normal salivary glands...
May 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28421244/texture-analysis-as-a-radiomic-marker-for-differentiating-renal-tumors
#13
HeiShun Yu, Jonathan Scalera, Maria Khalid, Anne-Sophie Touret, Nicolas Bloch, Baojun Li, Muhammad M Qureshi, Jorge A Soto, Stephan W Anderson
PURPOSE: To evaluate the utility of texture analysis for the differentiation of renal tumors, including the various renal cell carcinoma subtypes and oncocytoma. MATERIALS AND METHODS: Following IRB approval, a retrospective analysis was performed, including all patients with pathology-proven renal tumors and an abdominal computed tomography (CT) examination. CT images of the tumors were manually segmented, and texture analysis of the segmented tumors was performed...
April 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28416107/characteristics-of-the-peritumoral-pseudocapsule-vary-predictably-with-histologic-subtype-of-t1-renal-neoplasms-jacob-jm-williamson-sr-gondim-dd-leese-ja-terry-c-grignon-dj-boris-rs-urology-november-2015-86-5-956-961
#14
Oleksandr N Kryvenko
OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes. METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10mm...
June 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28416106/categorizing-renal-oncocytic-neoplasms-on-core-needle-biopsy-a-morphologic-and-immunophenotypic-study-of-144-cases-with-clinical-follow-up-alderman-ma-daignault-s-wolf-js-jr-palapattu-gs-weizer-az-hafez-ks-kunju-lp-wu-aj-hum-pathol-september-2016-55-1-10
#15
Oleksandr N Kryvenko
There is limited literature on renal oncocytic neoplasms diagnosed on core biopsy. All renal oncocytic neoplasm core biopsies from 2006 to 2013 were, retrospectively, reviewed. Morphologic features and an immunohistochemical panel of CK7, c-KIT, and S100A1 were assessed. Concordance with resection diagnosis, statistical analysis including a random forest classification, and follow-up were recorded. The postimmunohistochemical diagnoses of 144 renal oncocytic core biopsies were favor oncocytoma (67%), favor renal cell carcinoma (RCC) (12%), and cannot exclude RCC (21%)...
June 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28415596/renal-mass-biopsy-using-raman-spectroscopy-identifies-malignant-and-benign-renal-tumors-potential-for-pre-operative-diagnosis
#16
Yufei Liu, Zhebin Du, Jin Zhang, Haowen Jiang
The accuracy of renal mass biopsy to diagnose malignancy can be affected by multiple factors. Here, we investigated the feasibility of Raman spectroscopy to distinguish malignant and benign renal tumors using biopsy specimens. Samples were collected from 63 patients who received radical or partial nephrectomy, mass suspicious of cancer and distal parenchyma were obtained from resected kidney using an 18-gauge biopsy needle. Four Raman spectra were obtained for each sample, and Discriminant Analysis was applied for data analysis...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411376/nodular-oncocytic-hyperplasia-can-cytomorphology-allow-for-the-preoperative-diagnosis-of-a-nonneoplastic-salivary-disease
#17
Lisa M Rooper, Mine Onenerk, Momin T Siddiqui, William C Faquin, Justin A Bishop, Syed Z Ali
BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases...
April 14, 2017: Cancer
https://www.readbyqxmd.com/read/28379624/surgical-removal-of-a-choroid-plexus-oncocytoma-in-an-adult-cat
#18
B Cossic, G Silver, M Kent, E N Glass, D Agnew, S McDonough, A D Miller
An 11-year-old male castrated domestic shorthair cat presented with left central vestibular dysfunction. Magnetic resonance imaging of the brain revealed a large, extra-parenchymal, strongly contrast-enhancing mass at the level of the left cerebellopontine angle and compressing the cerebellum and brainstem. The mass was surgically excised via left rostral and sub-tentorial craniectomies and histopathology revealed an epithelial neoplasm composed of anastomosing cords of neoplastic cells that contained large amounts of finely granular hypereosinophilic cytoplasm and round nuclei...
April 5, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28363423/new-technique-for-nephron-sparing-surgery-in-polar-tumours-a-modification-of-the-kim-technique
#19
C Ameri, F M Lopez, G J Vitagliano, H Rios Pita, J M Guglielmi, L Blas
INTRODUCTION AND OBJECTIVES: Nephron-sparing surgery (NSS) is the indication, provided it is feasible and meets the international treatment guidelines. One of the objectives of performing NSS is to reduce the ischemia time as much as possible. We propose a surgical technique for treating polar renal tumours and those larger than 4cm based on the principle of the technique described by Kim in 1964. METHOD: The technique performs a continuous circular suture on the base of the tumour, achieving compression of the renal pole without vascular clamping, facilitating haemostasis and avoiding the blind transfixion performed in Kim's original technique...
March 28, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28360191/mir-10b-is-a-prognostic-marker-in-clear-cell-renal-cell-carcinoma
#20
Heba W Z Khella, Nicole Daniel, Leza Youssef, Andreas Scorilas, Roy Nofech-Mozes, Lorna Mirham, Sergey N Krylov, Evi Liandeau, Adriana Krizova, Antonio Finelli, Yufeng Cheng, George M Yousef
AIMS: Clear cell renal cell carcinoma (ccRCC) is the most common adult kidney cancer. It is an aggressive tumour with unpredictable outcome. The currently used clinical parameters are not always accurate for predicting disease behaviour. miR-10b is dysregulated in different malignancies including RCC. METHODS: We assessed the clinical utility of miR-10b as a prognostic marker in 250 patients with primary ccRCC. We examined the correlation between miR-10b and clinicopathological parameters...
March 30, 2017: Journal of Clinical Pathology
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