keyword
https://read.qxmd.com/read/38502259/oncocytoid-salivary-tumors-differential-diagnosis-and-utility-of-newly-described-immunohistochemistry
#1
REVIEW
Nora Katabi
BACKGROUND: Oncocytoid salivary tumors include several entities such as oncocytoma, Warthin tumor, secretory carcinoma (SC), salivary duct carcinoma (SDC), acinic cell carcinoma (AciCC), oncocytic mucoepidermoid carcinoma (OMEC), intraductal carcinoma, and epithelial myoepithelial carcinoma (EMC). This review investigates the differential diagnosis of oncocytoid salivary tumors and explore the role of newly described immunostains as valuable tools for their diagnosing and potentially guiding treatment options...
March 19, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38496753/renal-cell-oncocytoma-tumor-evolutions-a-case-report
#2
Alaa Khalid Alduraibi, Noora Bin Essa, Jamshed Bomanji
This report delineates the clinical progression of a renal oncocytoma in a 38-year-old female, initially asymptomatic, over a three-year follow-up period following her treatment for papillary thyroid cancer. The timeline of this case is as follows: In 2016, the patient was treated with total thyroidectomy and I131 for thyroid cancer. During an annual follow-up, an incidental renal mass was detected via FDG PET/CT, initially characterized as a benign, non-FDG-avid renal oncocytoma. Over two years, this lesion demonstrated a remarkable increase in FDG uptake and a slight growth in size, coupled with new I131 uptake in subsequent scans...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38475961/case-of-clear-cell-oncocytoma-of-parotid-gland-and-literature-review
#3
JOURNAL ARTICLE
Wencui Zhu, Yinglin Zhang, Fangfang Li, Guiyun Li, Peng Zhang, Hui Fang, Li Bian
Oncocytoma is a benign tumor of the salivary gland. Its incidence is very low and very seldom documen-ted in literature. Clear-cell dominant oncocytoma is even less common. The tumor's clinical symptoms and imaging results are nonspecific, so distinguishing other salivary gland tumors (such as oncocytic carcinoma) from clear-cell renal carcinoma is difficult, possibly leading to misdiagnosis and maltreatment. Here, a case of clear-cell dominant oncocytoma was presented, and the relevant literature was evaluated to investigate the diagnosis and management of clear-cell dominant oncocytoma...
February 1, 2024: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://read.qxmd.com/read/38464335/cushing-s-syndrome-caused-by-adrenocortical-oncocytoma-a-case-report
#4
Chengren Gou, Qingsong Jian, Maoqiang Tian, Jinghai Li, Yi Zhang, Zhenyu Guo
Adrenal cortical eosinophilic adenoma usually presents as non-functional adrenal tumor but may lead to Cushing's syndrome in patients. The present article reports a patient with Cushing's syndrome caused by right adrenocortical oncocytoma. The patient was treated in Urology Department of Wuchuan People's Hospital (Zunyi, China) in November 2022 because of hirsutism, weight gain and hypertension. A laparoscopic right adrenal tumor resection was performed using an abdominal approach. Following surgery, blood pressure and heart rate of the patient fluctuated within a healthy range and menstruation returned to normal...
April 2024: Oncology Letters
https://read.qxmd.com/read/38460672/l1cam-expression-and-molecular-alterations-distinguish-low-grade-oncocytic-tumor-lot-from-eosinophilic-chromophobe-renal-cell-carcinoma
#5
JOURNAL ARTICLE
Mohammed Alghamdi, Jie-Fu Chen, Achim Jungbluth, Sirma Koutzaki, Matthew B Palmer, Hikmat A Al-Ahmadie, Samson W Fine, Anuradha Gopalan, Judy Sarungbam, S Joseph Sirintrapun, Satish K Tickoo, Victor E Reuter, Ying-Bei Chen
Renal low-grade oncocytic tumor (LOT) is a recently recognized renal cell neoplasm designated within the "other oncocytic tumors" category in the 2022 WHO Classification. While the clinicopathologic, immunohistochemical, and molecular features reported for LOT have been largely consistent, the data is relatively limited. The morphologic overlap between LOT and other low grade oncocytic neoplasms, particularly eosinophilic chromophobe renal cell carcinoma (E-chRCC), remains a controversial area in renal tumor classification...
March 7, 2024: Modern Pathology
https://read.qxmd.com/read/38417405/pitfalls-in-salivary-gland-cytology
#6
REVIEW
Carla Saoud, Gabrielle Bailey, Ashleigh Graham, Lorena Marcano Bonilla, Sandra Sanchez, Zahra Maleki
BACKGROUND: Salivary gland lesions possess diagnostic challenges on fine needle aspiration (FNA) material. They are relatively uncommon, yet present with a wide spectrum of cytomorphology. Herein, we review common salivary gland neoplasms, their cytomorphologic features, their diagnostic pitfalls, and ancillary studies helpful in achieving an accurate diagnosis. SUMMARY: There are many cytomorphologic overlaps between benign and malignant salivary gland entities...
February 28, 2024: Acta Cytologica
https://read.qxmd.com/read/38398226/safety-and-diagnostic-efficacy-of-image-guided-biopsy-of-small-renal-masses
#7
JOURNAL ARTICLE
Muhamad Serhal, Sean Rangwani, Stephen M Seedial, Bartley Thornburg, Ahsun Riaz, Albert A Nemcek, Kent T Sato, Kent T Perry, Bonnie Choy, Robert J Lewandowski, Andrew C Gordon
INTRODUCTION: Image-guided renal mass biopsy is gaining increased diagnostic acceptance, but there are limited data concerning the safety and diagnostic yield of biopsy for small renal masses (≤4 cm). This study evaluated the safety, diagnostic yield, and management after image-guided percutaneous biopsy for small renal masses. METHODS: A retrospective IRB-approved study was conducted on patients who underwent renal mass biopsy for histopathologic diagnosis at a single center from 2015 to 2021...
February 19, 2024: Cancers
https://read.qxmd.com/read/38397036/elevated-plasma-concentration-of-4-pyridone-3-carboxamide-1-%C3%AE-d-ribonucleoside-4pyr-highlights-malignancy-of-renal-cell-carcinoma
#8
JOURNAL ARTICLE
Agata Jedrzejewska, Patrycja Jablonska, Teresa Gawlik-Jakubczak, Mateusz Czajkowski, Patrycja Maszka, Paulina Mierzejewska, Ryszard T Smolenski, Ewa M Slominska
Nicotinamide (NA) derivatives play crucial roles in various biological processes, such as inflammation, regulation of the cell cycle, and DNA repair. Recently, we proposed that 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR), an unusual derivative of NA, could be classified as an oncometabolite in bladder, breast, and lung cancer. In this study, we investigated the relations between NA metabolism and the progression, recurrence, metastasis, and survival of patients diagnosed with different histological subtypes of renal cell carcinoma (RCC)...
February 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38372764/low-grade-oncocytic-tumor-a-review-of-radiologic-and-clinical-features
#9
JOURNAL ARTICLE
Jessie L Chai, Stephanie E Siegmund, Michelle S Hirsch, Stuart G Silverman
PURPOSE: The 2022 World Health Organization classification of renal neoplasia expanded the spectrum of oncocytic neoplasms to encompass newly established and emerging entities; one of the latter is the low-grade oncocytic tumor (LOT). This study reports the radiologic appearance and clinical behavior of LOT. METHODS: In this IRB-approved, HIPPA-compliant retrospective study, our institution's pathology database was searched for low-grade oncocytic tumors or neoplasms...
February 19, 2024: Abdominal Radiology
https://read.qxmd.com/read/38358561/expression-of-foxi1-and-pou2f3-varies-among-different-salivary-gland-neoplasms-and-is-higher-in-warthin-tumor
#10
JOURNAL ARTICLE
Masahito Hoki, Yosuke Yamada, Emi Hiratomo, Masahiro Hirata, Yasuhide Takeuchi, Masayoshi Yoshimatsu, Masahiro Kikuchi, Yo Kishimoto, Alexander Marx, Hironori Haga
PURPOSE: Salivary gland tumors are histologically diverse. Ionocytes and tuft cells, rare epithelial cells found in normal salivary glands, might be associated with salivary tumors. Here, we explored the expression of FOXI1 and POU2F3, master regulators of ionocytes and tuft cells, respectively, for common salivary neoplasms using immunohistochemistry. METHODS: We analyzed normal salivary tissues and nine salivary gland tumors; Warthin tumors (WT), pleomorphic adenomas (PA), basal cell adenomas, and oncocytomas were benign, whereas mucoepidermoid, adenoid cystic, acinic cell, salivary duct carcinomas, and polymorphous adenocarcinomas were malignant...
February 15, 2024: Discover. Oncology
https://read.qxmd.com/read/38340966/actual-encounters-of-the-kidney-kind-exploring-48-cases-of-renal-collision-tumors-through-the-lens-of-literature
#11
JOURNAL ARTICLE
L Angelica Lerma, Garrison Pease, James Malleis, Tatjana Antic, Ondrej Hes, Maria Tretiakova
Multiple tumors of different lineages merging into a single mass, termed collision tumors, are considered a rare phenomenon in the kidney. Tumor components, or partners, may be malignant (including metastatic disease), borderline, or benign. We report the largest cohort to date of 48 cases. The cases were identified from the archives of three institutions in the last 16 years, including 43 (90%) with 2 tumor partners (dyad) and 5 (10%) with 3 partners (triad), totaling 101 individual neoplasms. The majority of cases involved immunohistochemical workup, and 5 underwent FISH or molecular studies...
March 2024: Human Pathology
https://read.qxmd.com/read/38338778/the-expression-of-alamandine-receptor-mrgd-in-clear-cell-renal-cell-carcinoma-is-associated-with-a-worse-prognosis-and-unfavorable-response-to-antiangiogenic-therapy
#12
JOURNAL ARTICLE
Gorka Larrinaga, Asier Valdivia, Inés Arrieta-Aguirre, Jon Danel Solano-Iturri, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Aida Santos-Martín, Amparo Pérez-Fernández, Javier C Angulo, José I López
Renal cell carcinoma (RCC) ranks among the most prevalent malignancies in Western countries, marked by its notable heterogeneity, which contributes to an unpredictable clinical trajectory. The insufficiency of dependable biomarkers adds complexity to assessing this tumor progression. Imbalances of several components of the intrarenal renin-angiotensin system (iRAS) significantly impact patient prognoses and responses to first-line immunotherapies. In this study, we analyzed the immunohistochemical expression of the Mas-related G-protein-coupled receptor D (MrgD), which recognizes the novel RAS peptide alamandine (ALA), in a series of 87 clear cell renal cell (CCRCCs), 19 papillary (PRCC), 7 chromophobe (ChRCC) renal cell carcinomas, and 11 renal oncocytomas (RO)...
January 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38284141/the-predictive-power-of-bosniak-3-and-4-cystic-renal-lesion-categorization-using-contrast-enhanced-ultrasound
#13
JOURNAL ARTICLE
Ákos Járay, Péter István Farkas, Dávid Semjén, Bálint Botz
OBJECTIVES: Contrast-enhanced ultrasound (CEUS) is increasingly utilized for the noninvasive assessment of renal cystic lesions, using the Bosniak grading system. Bosniak 3-4 lesions require surgical referral, which allows correlation with the histopathological outcome. METHODS: In this single-center, retrospective study we evaluated renal CEUS exams conducted with SonoVue® with a diagnosis of a Bosniak 3 or 4 lesion between 2019 and 2022. A total of 49 patients and 50 lesions met the inclusion criteria, 31 lesions had available histopathological results...
January 29, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38249277/a-cautionary-tale-a-case-report-describing-a-benign-parotid-oncocytoma-diagnosed-as-metastatic-squamous-cell-carcinoma-on-fine-needle-aspirate
#14
Danjel Miladinovic, Jodie Trautman, Takako Yabe
Parotid oncocytoma is a rare salivary gland tumour. Management does not require surgical intervention if diagnosed on a preoperative biopsy. A 64-year-old man presented with a parotid mass diagnosed as mcSCC on fine-needle aspiration cytology (FNAC). Surgical histopathology following parotidectomy demonstrated an oncocytoma of the parotid gland. Parotid oncocytomas are rare; therefore, diagnosis can be difficult. An MRI, CT, and US-guided biopsy are required for diagnosis. Ultrasound-guided core biopsy (UGSB) is more sensitive and specific when compared to FNAC for diagnosing malignant tumours...
December 2023: Curēus
https://read.qxmd.com/read/38242750/birt-hogg-dub%C3%A3-syndrome-in-an-overall-view-focus-on-the-clinicopathological-prospects-in-renal-tumors
#15
REVIEW
Jialong Wu, Jian Lu, Chin-Lee Wu, Min Lu
Birt-Hogg-Dubé syndrome (BHD) represents a rare autosomal dominant tumor predisposition syndrome characterized by skin lesions, lung cysts, and renal tumors. The predominant histological subtypes of BHD-related renal tumors include hybrid oncocytoma-chromophobe tumors, oncocytomas, and chromophobe renal cell carcinomas, all exhibiting eosinophilic/oncocytic features. Immunohistochemistry staining for KIT (CD117) and CK7 exhibits variability in these tumor types. Germline mutations in FLCN have been consistently identified...
January 6, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38241777/low-grade-oncocytic-renal-tumor-lot-clinicopathological-characterization-of-13-cases
#16
JOURNAL ARTICLE
Fawaz Almutairi, Bo Xu
CONTEXT: Low grade oncocytic tumor (LOT) is a recently recognized renal oncocytic neoplasm with unique morphologic and immunohistochemical pattern (CK7 +, CD117 -) that differentiates them from oncocytoma and chromophobe renal cell carcinoma (ChrRCC). OBJECTIVE: To further evaluate the histomorphological characteristics as well as the clinical outcome of low grade oncocytic tumors, retrospectively. DESIGN: Thirteen cases of LOT were identified from 463 cases of renal oncocytic neoplasm in our pathology archive...
February 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38195354/the-role-of-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-primary-staging-of-selected-renal-tumours-initial-experience-in-a-multicentre-cohort
#17
JOURNAL ARTICLE
Arsalan Tariq, Adam Pearce, Handoo Rhee, Samuel Kyle, Sheliyan Raveenthiran, Anita Pelecanos, Chun Loo Gan, Jeffrey C Goh, David Wong, Rhiannon McBean, Phillip Marsh, Steven Goodman, Nigel Dunglison, Rachel Esler, Anojan Navaratnam, John W Yaxley, Paul Thomas, David A Pattison, Matthew J Roberts
BACKGROUND: Accurate primary staging of renal cancer with conventional imaging is challenging. Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) may serve to improve the accuracy of renal cancer staging. OBJECTIVE: To determine clinicopathological and management differences for primary renal cancer staged with PSMA PET/CT in comparison to conventional imaging. DESIGN, SETTING, AND PARTICIPANTS: We conducted a retrospective cohort study of PSMA PET/CT scans performed for primary staging of renal cancer and incidental renal lesions at three sites in Brisbane, Australia between June 2015 and June 2020...
January 8, 2024: European Urology Focus
https://read.qxmd.com/read/38149604/utilization-of-re-vasc-the-novel-retroperitoneal-neovascularity-scoring-system-for-characterization-of-t1a-small-renal-masses
#18
MULTICENTER STUDY
Cameron Fateri, Bradley Roth, Sriram Rao, Akhil Peta, Luke Limfueco, Thanh-Lan Bui, Nina Kar, Justin Glavis-Bloom, Andrei Cumpanas, Jaime Landman, Roozbeh Houshyar
Purpose: Early characterization of small (T1a, <4 cm) renal masses is imperative for patient care and treatment planning. Renal biopsy is a sensitive and specific procedure that can accurately differentiate small renal masses as malignant or benign. However, it is an invasive procedure with a nonnegligible complication rate and is not performed routinely at most institutions. In this study, we sought to apply the Retroperitoneal Vascularity Assessment and Scoring in Carcinoma (Re-VASC) scoring system to T1a renal masses and analyzed whether it could differentiate these masses as benign or malignant...
March 2024: Journal of Endourology
https://read.qxmd.com/read/38145031/characteristics-of-the-patients-aged-less-than-40-years-operated-for-a-renal-mass
#19
JOURNAL ARTICLE
Abdullah Ilktac, Bayram Dogan, Cevper Ersoz, Ganime Coban, Senad Kalkan
The incidence of renal cell cancer (RCC) is low in individuals aged less than 40 years; however several studies have shown this increasing trend over the years. Hereditary syndromes are associated with RCC and are more frequently observed in early-onset cases. In this study, we investigated the characteristics of the patients, aged less than 40 years, who were operated for a renal mass with the suspicion of RCC. We analyzed patients aged <40 years who underwent partial or radical nephrectomy between January 2012 and December 2022...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38124760/intravascular-large-b-cell-lymphoma-masquerading-as-stroke-successfully-treated-with-r-hyper-cvad
#20
Christopher Popiolek, Kanchan Gupta, Mallorie L Huff, Ranju Gupta
Intravascular large B cell lymphoma (IVLBCL) is exceedingly rare and difficult to diagnose. We describe a case of IVLBCL in a 56-year-old male which was identified after recurrent strokes. Right partial nephrectomy was then performed which demonstrated renal oncocytoma and IVLBCL. Chemotherapy was initiated with standard R-Hyper-CVAD which included intrathecal methotrexate and cytarabine. R-CHOP is largely considered the treatment of choice in IVLBCL, however low doses of chemotherapy in this regimen do not cross the blood brain barrier like in R-Hyper-CVAD...
2024: Leukemia Research Reports
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