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https://www.readbyqxmd.com/read/28421244/texture-analysis-as-a-radiomic-marker-for-differentiating-renal-tumors
#1
HeiShun Yu, Jonathan Scalera, Maria Khalid, Anne-Sophie Touret, Nicolas Bloch, Baojun Li, Muhammad M Qureshi, Jorge A Soto, Stephan W Anderson
PURPOSE: To evaluate the utility of texture analysis for the differentiation of renal tumors, including the various renal cell carcinoma subtypes and oncocytoma. MATERIALS AND METHODS: Following IRB approval, a retrospective analysis was performed, including all patients with pathology-proven renal tumors and an abdominal computed tomography (CT) examination. CT images of the tumors were manually segmented, and texture analysis of the segmented tumors was performed...
April 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28416107/characteristics-of-the-peritumoral-pseudocapsule-vary-predictably-with-histologic-subtype-of-t1-renal-neoplasms-jacob-jm-williamson-sr-gondim-dd-leese-ja-terry-c-grignon-dj-boris-rs-urology-november-2015-86-5-956-961
#2
Oleksandr N Kryvenko
OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes. METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10mm...
April 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28416106/categorizing-renal-oncocytic-neoplasms-on-core-needle-biopsy-a-morphologic-and-immunophenotypic-study-of-144-cases-with-clinical-follow-up-alderman-ma-daignault-s-wolf-js-jr-palapattu-gs-weizer-az-hafez-ks-kunju-lp-wu-aj-hum-pathol-september-2016-55-1-10
#3
Oleksandr N Kryvenko
There is limited literature on renal oncocytic neoplasms diagnosed on core biopsy. All renal oncocytic neoplasm core biopsies from 2006 to 2013 were, retrospectively, reviewed. Morphologic features and an immunohistochemical panel of CK7, c-KIT, and S100A1 were assessed. Concordance with resection diagnosis, statistical analysis including a random forest classification, and follow-up were recorded. The postimmunohistochemical diagnoses of 144 renal oncocytic core biopsies were favor oncocytoma (67%), favor renal cell carcinoma (RCC) (12%), and cannot exclude RCC (21%)...
April 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28415596/renal-mass-biopsy-using-raman-spectroscopy-identifies-malignant-and-benign-renal-tumors-potential-for-pre-operative-diagnosis
#4
Yufei Liu, Zhebin Du, Jin Zhang, Haowen Jiang
The accuracy of renal mass biopsy to diagnose malignancy can be affected by multiple factors. Here, we investigated the feasibility of Raman spectroscopy to distinguish malignant and benign renal tumors using biopsy specimens. Samples were collected from 63 patients who received radical or partial nephrectomy, mass suspicious of cancer and distal parenchyma were obtained from resected kidney using an 18-gauge biopsy needle. Four Raman spectra were obtained for each sample, and Discriminant Analysis was applied for data analysis...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411376/nodular-oncocytic-hyperplasia-can-cytomorphology-allow-for-the-preoperative-diagnosis-of-a-nonneoplastic-salivary-disease
#5
Lisa M Rooper, Mine Onenerk, Momin T Siddiqui, William C Faquin, Justin A Bishop, Syed Z Ali
BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases...
April 14, 2017: Cancer
https://www.readbyqxmd.com/read/28379624/surgical-removal-of-a-choroid-plexus-oncocytoma-in-an-adult-cat
#6
B Cossic, G Silver, M Kent, E N Glass, D Agnew, S McDonough, A D Miller
An 11-year-old male castrated domestic shorthair cat presented with left central vestibular dysfunction. Magnetic resonance imaging of the brain revealed a large, extra-parenchymal, strongly contrast-enhancing mass at the level of the left cerebellopontine angle and compressing the cerebellum and brainstem. The mass was surgically excised via left rostral and sub-tentorial craniectomies and histopathology revealed an epithelial neoplasm composed of anastomosing cords of neoplastic cells that contained large amounts of finely granular hypereosinophilic cytoplasm and round nuclei...
April 5, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28363423/new-technique-for-nephron-sparing-surgery-in-polar-tumours-a-modification-of-the-kim-technique
#7
C Ameri, F M Lopez, G J Vitagliano, H Rios Pita, J M Guglielmi, L Blas
INTRODUCTION AND OBJECTIVES: Nephron-sparing surgery (NSS) is the indication, provided it is feasible and meets the international treatment guidelines. One of the objectives of performing NSS is to reduce the ischemia time as much as possible. We propose a surgical technique for treating polar renal tumours and those larger than 4cm based on the principle of the technique described by Kim in 1964. METHOD: The technique performs a continuous circular suture on the base of the tumour, achieving compression of the renal pole without vascular clamping, facilitating haemostasis and avoiding the blind transfixion performed in Kim's original technique...
March 28, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28360191/mir-10b-is-a-prognostic-marker-in-clear-cell-renal-cell-carcinoma
#8
Heba W Z Khella, Nicole Daniel, Leza Youssef, Andreas Scorilas, Roy Nofech-Mozes, Lorna Mirham, Sergey N Krylov, Evi Liandeau, Adriana Krizova, Antonio Finelli, Yufeng Cheng, George M Yousef
AIMS: Clear cell renal cell carcinoma (ccRCC) is the most common adult kidney cancer. It is an aggressive tumour with unpredictable outcome. The currently used clinical parameters are not always accurate for predicting disease behaviour. miR-10b is dysregulated in different malignancies including RCC. METHODS: We assessed the clinical utility of miR-10b as a prognostic marker in 250 patients with primary ccRCC. We examined the correlation between miR-10b and clinicopathological parameters...
March 30, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28357787/visual-evaluation-and-differentiation-of-renal-oncocytomas-from-renal-cell-carcinomas-by-means-of-99m-tc-sestamibi-spect-ct
#9
Antonios Tzortzakakis, Ove Gustafsson, Mattias Karlsson, Linnea Ekström-Ehn, Rammin Ghaffarpour, Rimma Axelsson
BACKGROUND: Despite the progress in the quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% of all solid renal tumours turn out to be oncocytomas. In actual clinical practice, this is verified only following unnecessary surgery or a renal biopsy/ablation. The objective of our pilot study examines whether (99m)Tc-sestamibi SPECT/CT can play a crucial role in the characterization of solid renal neoplasms and the differentiation of oncocytomas from renal cell carcinomas...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28325361/warthin-like-papillary-renal-cell-carcinoma-clinicopathologic-morphologic-immunohistochemical-and-molecular-genetic-analysis-of-11-cases
#10
Faruk Skenderi, Monika Ulamec, Tomas Vanecek, Petr Martinek, Reza Alaghehbandan, Maria Pane Foix, Iva Babankova, Delia Perez Montiel, Isabel Alvarado-Cabrero, Marian Svajdler, Pavol Dubinský, Dana Cempirkova, Michal Pavlovsky, Semir Vranic, Ondrej Daum, Ondrej Ondic, Kristyna Pivovarcikova, Kvetoslava Michalova, Milan Hora, Pavla Rotterova, Adela Stehlikova, Martin Dusek, Michal Michal, Ondrej Hes
Oncocytic papillary renal cell carcinoma (PRCC) is a distinct subtype of PRCC, listed as a possible new variant of PRCC in the 2016 WHO classification. It is composed of papillae aligned by large single-layered eosinophilic cells showing linearly arranged oncocytoma-like nuclei. We analyzed clinicopathologic, morphologic, immunohistochemical and molecular-genetic characteristics of 11 oncocytic PRCCs with prominent tumor lymphocytic infiltrate, morphologically resembling Warthin's tumor. The patients were predominantly males (8/11, 73%), with an average age of 59years (range 14-76), and a mean tumor size of 7cm (range 1-22cm)...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28315424/diagnostic-criteria-for-oncocytic-renal-neoplasms-a-survey-of-urologic-pathologists
#11
Sean R Williamson, Ramya Gadde, Kiril Trpkov, Michelle S Hirsch, John R Srigley, Victor E Reuter, Liang Cheng, L Priya Kunju, Ravi Barod, Craig G Rogers, Brett Delahunt, Ondrej Hes, John N Eble, Ming Zhou, Jesse K McKenney, Guido Martignoni, Stewart Fleming, David J Grignon, Holger Moch, Nilesh S Gupta
Renal oncocytoma and chromophobe renal cell carcinoma (RCC) have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17/26 invitees. Histologically, >1 mitotic figure was regarded as most worrisome (n=10) or incompatible (n=6) with oncocytoma diagnosis. Interpretation of focal nuclear wrinkling, focal perinuclear clearing, and multinucleation depended on extent and did not necessarily exclude oncocytoma if minor...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28295484/who-2016-classification-changes-and-advancements-in-the-diagnosis-of-miscellaneous-primary-cns-tumours
#12
Felix Sahm, David E Reuss, Caterina Giannini
This short review highlights significant changes and recent findings incorporated to varying extent in the WHO 2016 definition of a variety of tumours, including peripheral nerve sheath tumours, meningiomas, mesenchymal non-meningothelial tumours, melanocytic tumours, lymphomas and histiocytic tumours, germ cell tumours and non-neuroendocrine pituitary tumours. Most notable classification changes include: adding "hybrid nerve sheath tumours" to the spectrum of benign nerve sheath tumours; an updated definition of atypical meningioma (WHO grade II), including cases with brain invasion; recognizing dural solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) as a single tumour entity characterized by NAB2 and STAT6 gene fusions for which the term solitary SFT/HPC was chosen; recognizing that pituitary granular cell tumour, spindle cell oncocytoma, and pituicytoma all share nuclear expression of TTF-1, possibly representing a spectrum of a single nosological entity derived from posterior pituitary glial cells...
March 12, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28286028/spindle-cell-oncocytoma-report-of-two-cases-with-massive-bleeding-and-review-of-the-literature
#13
REVIEW
Domenico Billeci, Elisabetta Marton, Enrico Giordan, Valentina Carraro, Monica Ronzon, Sabrina Rossi
Spindle cell oncocytoma (SCO) is a rare pituitary tumor, classified as a WHO grade I neoplasm. Due to its rarity, SCO is often preoperatively misdiagnosed as a pituitary macroadenoma. In the present study we report two recent cases of SCO, a 61-year-old male and a 65-year-old female presenting at Treviso General Hospital between March 2014 and April 2015. Tumor resection was achieved by endoscopic transsphenoidal approach but massive hemorrhagic events hampered surgery, endangering the patient's life in both cases...
March 9, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28280876/quantitative-computer-aided-diagnostic-algorithm-for-automated-detection-of-peak-lesion-attenuation-in-differentiating-clear-cell-from-papillary-and-chromophobe-renal-cell-carcinoma-oncocytoma-and-fat-poor-angiomyolipoma-on-multiphasic-multidetector-computed
#14
Heidi Coy, Jonathan R Young, Michael L Douek, Matthew S Brown, James Sayre, Steven S Raman
OBJECTIVE: To evaluate the performance of a novel, quantitative computer-aided diagnostic (CAD) algorithm on four-phase multidetector computed tomography (MDCT) to detect peak lesion attenuation to enable differentiation of clear cell renal cell carcinoma (ccRCC) from chromophobe RCC (chRCC), papillary RCC (pRCC), oncocytoma, and fat-poor angiomyolipoma (fp-AML). MATERIALS AND METHODS: We queried our clinical databases to obtain a cohort of histologically proven renal masses with preoperative MDCT with four phases [unenhanced (U), corticomedullary (CM), nephrographic (NP), and excretory (E)]...
March 9, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28271050/incidental-finding-of-adrenal-oncocytoma-after-right-robotic-adrenalectomy-case-report-and-literature-review
#15
Othman Alamoudi, Wael Alsulaiman, Naif Aldhaam, Maher Moazin
Oncocytic neoplasms occur in several organs and are most commonly found in the thyroid, kidneys and salivary glands. Oncocytic neoplasms of the adrenal cortex are extremely rare and are usually non-functioning, benign and incidentally detected. However, histologically, they are characterized by cells with eosinophilic granular cytoplasm and numerous packed mitochondria. We report a case of 33 year old lady medically free complain of right flank pain radiated to the lower abdomen, not associated with any aggravating or relieving factor or any other symptom there was no evidence of hypertension symptom, by the Magnetic resonance imaging (MRI) showed that she has large heterogeneous mass seen at the right adrenal gland, and it was managed successfully by Robot-Assisted Right Adrenalectomy...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28268233/does-computed-tomography-still-have-limitations-to-distinguish-benign-from-malignant-renal-tumors-for-radiologists
#16
Toshitaka Shin, Vinay A Duddalwar, Osamu Ukimura, Toru Matsugasumi, Frank Chen, Nariman Ahmadi, Andre Luis de Castro Abreu, Hiromitsu Mimata, Inderbir S Gill
OBJECTIVES: To evaluate the current accuracy of CT for diagnosing benign renal tumors. MATERIALS AND METHODS: We retrospectively reviewed 905 patients who underwent preoperative CT followed by surgical resection. The final pathology was benign in 156 patients (17%). After exclusions, 140 patients with 163 benign tumors were included and 3 sets of the CT interpretations by radiologists with varying levels of experience were analyzed. RESULTS: The histological breakdown was as follows: oncocytomas (54...
March 8, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28260171/renal-tumors-with-low-signal-intensities-on-t2-weighted-mr-image-radiologic-pathologic-correlation
#17
REVIEW
Youyeon Kim, Deuk Jae Sung, Ki Choon Sim, Na Yeon Han, Beom Jin Park, Min Ju Kim, Sung Bum Cho
Accurate characterization of renal masses is essential for ensuring appropriate management. Low T2 signal intensity is a common feature of papillary renal cell carcinoma and fat-poor angiomyolipoma. Nonetheless, other types of renal cell carcinoma, oncocytoma, hemangioma, lymphoma, leiomyoma, and urothelial cell carcinoma also can show low signal intensities on T2-weighted imaging (T2WI). Histopathologic features that can lead to low T2 signal intensities in renal tumors include smooth muscle component, papillary architecture, a high nucleus-to-cytoplasm ratio, and hemorrhage...
March 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28237146/is-routine-histopathological-examination-of-dacryocystorhinostomy-dacryocystectomy-specimens-necessary-a-tertiary-eye-hospital-experience
#18
Hind Alkatan, Majed Al-Qurashi
PURPOSE: Limited literature documenting the incidence of unsuspected malignant neoplasm among dacryocystorhinostomy/Dacryocystectomy (DCR/DCT) specimens is reviewed to determine if routine biopsy of all the patients undergoing such procedures is required. We are evaluating if sending lacrimal sac specimens for histopathological examination is necessary as a routine patient's care standard. STUDY DESIGN: This is a retrospective study of all lacrimal sac specimens received for histopathological examination in a tertiary eye hospital over a period of 12 years...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28197683/aorta-lesion-attenuation-difference-alad-on-contrast-enhanced-ct-a-potential-imaging-biomarker-for-differentiating-malignant-from-benign-oncocytic-neoplasms
#19
Manish Dhyani, Joseph R Grajo, Dayron Rodriguez, Zhikui Chen, Adam Feldman, Rosemary Tambouret, Debra A Gervais, Ronald S Arellano, Peter F Hahn, Anthony E Samir
OBJECTIVE: To evaluate whether the Aorta-Lesion-Attenuation-Difference on contrast-enhanced CT can aid in the differentiation of malignant and benign oncocytic renal neoplasms. MATERIALS AND METHODS: Two independent cohorts-an initial (biopsy) dataset and a validation (surgical) dataset-with oncocytomas and chromophobe renal cell carcinomas (chRCC) were included in this IRB-approved retrospective study. A region of interest was placed on the renal mass and abdominal aorta on the same CT image slice to calculate an Aorta-Lesion-Attenuation-Difference (ALAD)...
February 14, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28130580/-what-can-should-be-treated-in-kidney-tumors-and-when
#20
C M Sommer, D F Vollherbst, G M Richter, H U Kauczor, P L Pereira
CLINICAL/METHODICAL ISSUE: In the treatment of localized renal cell carcinoma, the lack of randomization in controlled trials on thermal ablation is a major limitation. The latter leads to significant study bias and it ultimately remains unclear whether the improved overall survival in favor of partial nephrectomy can actually be attributed to the treatment method. STANDARD RADIOLOGICAL METHODS: For T1a (≤4 cm) renal cell carcinoma without lymph node and distant metastases, excellent technical and clinical results have been described after imaging-guided radiofrequency ablation and cryoablation...
February 2017: Der Radiologe
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