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https://www.readbyqxmd.com/read/29146062/three-cases-of-adrenocortical-tumors-mistaken-for-hepatocellular-carcinomas-diagnostic-pitfalls-and-differential-diagnosis
#1
Won Young Park, Hyung Il Seo, Kyung Un Choi, Ahrong Kim, Young Keum Kim, So Jeong Lee, Chang Hun Lee, Gi Yeong Huh, Do Youn Park
Adrenocortical adenomas and carcinomas in other parenchyma are extremely rare, with few cases reported and because of the rarity of these tumors, they occasionally cause problems during diagnosis. Adrenal cortical neoplasms in liver parenchyma can be present in 3 forms, including direct invasion or adhesion to liver parenchyma, tumors arising in adrenohepatic fusion tissue or in ectopic adrenal gland tissue. We report 3 cases of adrenal cortical tumors that were misdiagnosed as hepatocellular carcinoma in the preoperative state...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29132724/emerging-entities-in-renal-cell-neoplasia-thyroid-like-follicular-renal-cell-carcinoma-and-multifocal-oncocytoma-like-tumours-associated-with-oncocytosis
#2
REVIEW
John N Eble, Brett Delahunt
The list of accepted entities of renal cell neoplasia has burgeoned since the turn of the century through recognition of rare tumour types and the discovery of genetic mutations driving renal neoplasia syndromes. This growth has not finished and in this report we present examples of each of these types which were not included in the 2016 World Health Organization classification of renal neoplasia, but are candidates for inclusion in the next edition of the classification. Thyroid-like follicular renal cell carcinoma is a rare tumour type with a distinctive microscopic appearance resembling follicles of the thyroid gland...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29118533/pathological-nature-of-renal-tumors-does-size-matter
#3
Lutfi Ali S Kurban, Alireza Vosough, Preman Jacob, Deepak Prasad, Thomas Lam, Neil Scott, Bhaskar K Somani
Introduction: We examined the relationship between the size and nature of renal masses in term of malignant potential, histological grading, pathological staging and presence of necrosis and sarcomatoid changes. Materials and Methods: Retrospectively, we reviewed 323 consecutive nephrectomies between 2000 and 2010. Final pathology was correlated with tumour size. The renal tumours were stratified into three groups according to the largest diameter, defined as 4 cm or smaller, greater than 4 cm to 7 cm, and greater than 7 cm...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29099276/setdb2-and-riox2-are-differentially-expressed-among-renal-cell-tumor-subtypes-associating-with-prognosis-and-metastization
#4
Maria João Ferreira, Ana Sílvia Pires-Luís, Márcia Vieira-Coimbra, Pedro Costa-Pinheiro, Luís Antunes, Paula C Dias, Francisco Lobo, Jorge Oliveira, Céline S Gonçalves, Bruno M Costa, Rui Henrique, Carmen Jerónimo
Increasing detection of small renal masses by imaging techniques entails the need for accurate discrimination between benign and malignant renal cell tumors (RCTs) as well as among malignant RCTs, owing to differential risk of progression through metastization. Although histone methylation has been implicated in renal tumorigenesis, its potential as biomarker for renal cell carcinoma (RCC) progression remains largely unexplored. Thus, we aimed to characterize the differential expression of histone methyltransferases (HMTs) and histone demethylases (HDMs) in RCTs to assess their potential as metastasis biomarkers...
November 3, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29090117/modern-pathologic-diagnosis-of-renal-oncocytoma
#5
REVIEW
Sara E Wobker, Sean R Williamson
Oncocytoma is a well-defined benign renal tumor, with classic gross and histologic features, including a tan or mahogany-colored mass with central scar, microscopic nested architecture, bland cytology, and round, regular nuclei with prominent central nucleoli. As a result of variations in this classic appearance, difficulty in standardizing diagnostic criteria, and entities that mimic oncocytoma, such as eosinophilic variant chromophobe renal cell carcinoma and succinate dehydrogenase-deficient renal cell carcinoma, pathologic diagnosis remains a challenge...
2017: Journal of Kidney Cancer and VHL
https://www.readbyqxmd.com/read/29079496/an-in-vivo-prospective-study-of-the-diagnostic-yield-and-accuracy-of-optical-biopsy-compared-with-conventional-renal-mass-biopsy-for-the-diagnosis-of-renal-cell-carcinoma-the-interim-analysis
#6
Mara Buijs, Peter G K Wagstaff, Daniel M de Bruin, Patricia J Zondervan, Cemile Dilara Savci-Heijink, Otto M van Delden, Ton G van Leeuwen, R Jeroen A van Moorselaar, Jean J M C H de la Rosette, Maria Pilar Laguna Pes
BACKGROUND: Lack of accuracy in preoperative imaging leads to overtreatment of benign renal masses (RMs) or indolent renal cell carcinomas (RCCs). Optical coherence tomography (OCT) is real time and high resolution, enabling quantitative analysis through attenuation coefficient (μOCT, mm(-1)). OBJECTIVE: To determine the accuracy and diagnostic yield of OCT and renal mass biopsy (RMB) for the differentiation of benign RMs versus RCC and oncocytoma versus RCC. DESIGN, SETTING, AND PARTICIPANTS: From October 2013 to June 2016, 95 patients with solid enhancing RMs on cross-sectional imaging were prospectively included...
October 24, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29071436/measurement-and-scan-reproducibility-of-parameters-of-intravoxel-incoherent-motion-in-renal-tumor-and-normal-renal-parenchyma-a-preliminary-research-at-3-0%C3%A2-t-mr
#7
Jingjing Pan, Hongtao Zhang, Fengyuan Man, Yanguang Shen, Yingwei Wang, Yan Zhong, Lu Ma, Haiyi Wang, Huiyi Ye
PURPOSE: To prospectively estimate measurement and scan reproducibility of parameters of intravoxel incoherent motion (IVIM) in renal tumors, normal renal cortex, and medulla. METHODS: Twenty-four consecutive patients (twelve males and twelve females; median age 56.7 years, range 32-71 years) with 25 renal tumors (20 renal cell carcinomas, one urothelium carcinoma, three angiomyolipomas, and one oncocytoma) were examined twice using IVIM1 and IVIM2 with 9 and 16 b values, respectively, at 3...
October 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29030073/comparative-analysis-of-surgery-thermal-ablation-and-active-surveillance-for-renal-oncocytic-neoplasms
#8
Brady L Miller, Lori Mankowski Gettle, Jason R Van Roo, Timothy J Ziemlewicz, Sara L Best, Shane A Wells, Meghan G Lubner, J Louis Hinshaw, Fred T Lee, Stephen Y Nakada, Wei Huang, E Jason Abel
OBJECTIVE: To compare oncologic and procedural outcomes for renal oncocytic tumors treated with surgery, thermal ablation or active surveillance. METHODS AND MATERIALS: Clinical and pathologic data were collected for consecutive patients with a histological diagnosis of oncocytoma, oncocytic neoplasm or chromophobe renal cell cancers (chRCC) from 2003-2016. Independent pathology and radiology review was performed for this study. RESULTS: Of 171 patients, tumor histology included oncocytoma (n=122), chRCC (n=47) and oncocytic neoplasm not otherwise specified (n=2)...
October 10, 2017: Urology
https://www.readbyqxmd.com/read/29024738/new-hybrid-mini-laparoendoscopic-single-site-mi-less-partial-nephrectomy-with-early-unclamped-technique-for-renal-tumors-with-intermediate-padua-score-ideal-phase-2a
#9
Christopher Springer, Felix Kawan, Roberto La Rocca, Nasreldin Mohammed, Paolo Fornara, Vincenzo Mirone, Francesco Greco
OBJECTIVE: To evaluate a new hybrid technique which we defined mini-laparoendoscopic single-site partial nephrectomy (MILESS-PN) for renal masses presenting an intermediate PADUA score. MATERIAL AND METHODS: Forty consecutive cases of MILESS-PN performed between April 2013 and November 2015 were included in this study. MILESS consisted in the simultaneous use of two 3 mm pararectal trocars and an umbilical SILS trocar; the sequence of steps of MILESS-PN was comparable to standard laparoscopic partial nephrectomy...
October 9, 2017: Urology
https://www.readbyqxmd.com/read/28989884/diagnosis-of-adrenocortical-tumors-by-reticulin-algorithm
#10
Daphne Fonseca, Sudha S Murthy, K Ravindranath Tagore, B Vishal Rao, Subramanyeshwar Rao Thamminedi, K V V N Raju, Rakesh Sharma, Sundaram Challa
AIMS: To apply reticulin algorithm (RA) to the diagnosis of adrenocortical tumors on adrenalectomy specimens and compare its efficacy to the modified Weiss criteria or Lin-Weiss-Bisceglia (LWB) criteria for oncocytic variant. MATERIALS AND METHODS: Adrenocortical tumors (ACTs) diagnosed on resected specimens including the variants during January 2010-June 2016 were retrieved from the pathology records. The demographic and clinical data were obtained from medical records...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28981362/the-abcs-of-bhd-an-in-depth-review-of-birt-hogg-dub%C3%A3-syndrome
#11
Shiva Gupta, Hyunseon C Kang, Dhakshinamoorthy Ganeshan, Ajaykumar Morani, Rabindra Gautam, Peter L Choyke, Vikas Kundra
OBJECTIVE: Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant inherited syndrome involving multiple organs. In young patients, renal neoplasms that are multiple, bilateral, or both, such as oncocytomas, chromophobe renal cell carcinoma (RCC), hybrid chromophobe RCC-oncocytomas, clear cell RCC, and papillary RCC, can suggest BHD syndrome. Extrarenal findings, including dermal lesions, pulmonary cysts, and spontaneous pneumothoraces, also aid in diagnosis. CONCLUSION: Radiologists may be one of the first medical specialists to suggest the diagnosis of BHD syndrome...
October 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28975890/identification-and-validation-of-novel-prognostic-markers-in-renal-cell-carcinoma
#12
Maj Rabjerg
Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the surveillance protocols for follow-up of RCC patients after radical nephrectomy are based on the American Joint Committee on Cancers (AJCC) pathological tumor-node-metastasis (TNM) classification system...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28971329/correlation-of-99m-tc-sestamibi-uptake-in-renal-masses-with-mitochondrial-content-and-multi-drug-resistance-pump-expression
#13
Steven P Rowe, Michael A Gorin, Lilja B Solnes, Mark W Ball, Ajuni Choudhary, Phillip M Pierorazio, Jonathan I Epstein, Mehrbod S Javadi, Mohamad E Allaf, Alex S Baras
BACKGROUND: (99m)Tc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has recently been explored for the characterization of indeterminate renal masses. As judged by increased intra-tumoral radiotracer uptake, we have previously reported the excellent diagnostic performance characteristics of this test for identifying benign/indolent oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs). In this study, we investigated potential molecular mechanisms underlying the discriminatory ability of (99m)Tc-sestamibi SPECT/CT for renal masses...
October 2, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28968156/oncocytic-renal-neoplasms-on-resections-and-core-biopsies-our-approach-to-this-challenging-differential-diagnosis
#14
REVIEW
Angela Wu
Distinguishing oncocytomas from their malignant mimics is very challenging. This review highlights our approach to classifying low-grade oncocytic tumors on both resections and biopsies. We also discuss how we use immunohistochemical stains in this challenging differential diagnosis.
October 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28943925/genomic-and-immunohistochemical-characterisation-of-a-lacrimal-gland-oncocytoma-and-review-of-literature
#15
Lauge Hjorth Mikkelsen, Simon Andreasen, Linea Cecilie Melchior, Marta Persson, Jeppe Dyrberg Andersen, Vania Pereira, Peter Bjerre Toft, Niels Morling, Göran Stenman, Steffen Heegaard
The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28940297/periocular-cutaneous-oncocytoma
#16
S Menzies, D McKenna, P Hartel
No abstract text is available yet for this article.
September 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28923625/genitourinary-malignancies-in-transplant-or-dialysis-patients-the-frequency-of-two-newly-described-2016-world-health-organization-histopathologic-types
#17
A Billis, L L L Freitas, L B E Costa, I S Barreto, M A Asato, K S Araujo, D M Losada, A P Herculiani, G V B S Tabosa, B C Zaidan, G L P Oliveira, L Q A Bastos, R M Rocha
BACKGROUND: The aim of this study was to revise the histopathologic types of neoplasias in the genitourinary tract and determine the frequency of 2 new entities included in the 2016 book of World Health Organization classification of renal tumors. It is not established so far whether these 2 recently described tumors are the most frequent in association with end-stage kidney disease. METHODS: In a retrospective analysis, we revised the histopathologic type of 37 genitourinary tumors from 21 patients in dialysis and/or submitted to renal transplantation from 2003 to 2016 aiming to find the frequency of acquired cystic disease-associated renal cell carcinoma and clear cell papillary (tubulopapillary) renal cell carcinoma...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28918618/concurrent-oncocytoma-and-two-angiomyolipomas-in-a-diabetic-kidney-a-very-rare-condition
#18
Fariba Abbasi, Ata Abbasi, Mansour Alizadeh, Parisa Modarresi
Angiomyolipoma (AML) and oncocytoma are uncommon benign neoplasms of the kidney which their simultaneous occurrence in the same kidney is extremely rare. This study reports a 60-year-old diabetic woman with the rare simultaneous occurrence of three renal masses. Histologic evaluation revealed two angiomyolipomas and one oncocytoma within the same kidney, in a background of histologic features of diabetic nephropathy. Renal angiomyolipoma and oncocytoma are uncommon neoplasms, and their simultaneous occurrence in the same kidney is extremely rare...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28900880/characterizing-indeterminate-renal-masses-with-molecular-imaging-the-role-of-99m-tc-mibi-spect-ct
#19
REVIEW
Andrew M Reynolds, Kristin Kelly Porter
PURPOSE OF REVIEW: The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of (99m)Tc-MIBI SPECT/CT in preoperative differentiation of enhancing renal masses. RECENT FINDINGS: Recent reports have shown that (99m)Tc-MIBI SPECT/CT imaging can differentiate mitochondrial-rich, benign, or indolent renal masses from renal cell carcinoma...
September 12, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28898443/re-evaluation-of-33-unclassified-eosinophilic-renal-cell-carcinomas-in-young-patients
#20
Yunjie Li, Victor E Reuter, Andres Matoso, George J Netto, Jonathan I Epstein, Pedram Argani
AIMS: We sought to determine if some unclassified renal cell carcinomas (RCCs) in children and young adults that are characterized by predominantly eosinophilic cytoplasm are related to the recently described succinate dehydrogenase (SDH)-deficient RCC, fumarate hydratase (FH)-deficient RCC, or eosinophilic solid and cystic (ESC) RCC. METHODS AND RESULTS: We reviewed 33 unclassified RCCs with predominantly eosinophilic cytoplasm in patients age 35 years or younger...
September 12, 2017: Histopathology
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