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https://www.readbyqxmd.com/read/29762256/computed-tomography-perfusion-measurements-in-renal-lesions-obtained-by-bayesian-estimation-advanced-singular-value-decomposition-deconvolution-maximum-slope-and-patlak-models-intermodel-agreement-and-diagnostic-accuracy-of-tumor-classification
#1
Dominik Deniffel, Timothé Boutelier, Aissam Labani, Mickael Ohana, Daniela Pfeiffer, Catherine Roy
OBJECTIVES: The aims of this study were to evaluate the agreement of computed tomography (CT)-perfusion parameter values of the normal renal cortex and various renal tumors, which were obtained by different mathematical models, and to evaluate their diagnostic accuracy. MATERIALS AND METHODS: Perfusion imaging was performed prospectively in 35 patients to analyze 144 regions of interest of the normal renal cortex and 144 regions of interest of renal tumors, including 21 clear-cell renal cell carcinomas (RCC), 6 papillary RCCs, 5 oncocytomas, 1 chromophobe RCC, 1 angiomyolipoma with minimal fat, and 1 tubulocystic RCC...
May 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29752278/identification-and-validation-of-radiographic-enhancement-for-reliable-differentiation-of-cd117-benign-renal-oncocytoma-and-chromophobe-renal-cell-carcinoma
#2
Jay Amin, Bo Xu, Shervin Badkhshan, Terrance T Creighton, Daniel Abbotoy, Christine Murekeyisoni, Kristopher Attwood, Thomas Schwaab, Craig Hendler, Michael Petroziello, Charles L Roche, Eric C Kauffman
PURPOSE: The diagnostic differential for CD117/KIT(+) oncocytic renal tumor biopsies is limited to benign renal oncocytoma (RO) vs. chromophobe renal cell carcinoma (ChRCC), however further differentiation is often challenging and requires surgical resection.  We investigated clinical variables that might improve preoperative differentiation of CD117(+) RO vs. ChRCC to avoid the need for benign tumor resection. EXPERIMENTAL DESIGN: 124 nephrectomy patients from a single institute with 133 RO or ChRCC tumors were studied...
May 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29744641/evaluation-of-renal-lesions-using-contrast-enhanced-ultrasound-ceus-a-10-year-retrospective-european-single-centre-analysis
#3
Johannes Rübenthaler, G Negrão de Figueiredo, K Mueller-Peltzer, D A Clevert
OBJECTIVE: To investigate the usefulness of contrast-enhanced ultrasound (CEUS) in the evaluation of renal masses. METHODS: This study included 255 patients with renal masses. Ages ranged from 18-86 years. CEUS was used for determining malignancy or benignancy and findings were correlated with the histopathological outcome. Out of 255 lesions, 212 lesions were malignant (83.1%) and 43 were benign (16.9%). Diagnostic accuracy was tested using the histopathological diagnosis as the gold standard...
May 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29738030/renal-oncocytoma-in-a-kidney-transplant-patient-the-imaging-features-on-contrast-enhanced-ultrasonography-ceus-a-case-report
#4
Lucia Alejandra Alfaro Villanueva, Maira Knust, Leonardo Quintella, José Hermógenes R Suassuna, Nordeval C Araújo
Renal oncocytoma is an infrequently reported renal neoplasm, often asymptomatic, which usually behaves as a benign entity and is identified accidentally on radiological imaging. Transplant patients under long-term immunosuppressive drugs have a high prevalence of cancers, such as skin cancers, lymphoproliferative disorders, and renal carcinomas. We present a case report of an asymptomatic renal oncocytoma in a kidney transplant recipient presenting persistent hematuria. The features of computed tomography and contrast-enhanced ultrasound (CEUS) are presented...
April 19, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29726953/genetic-characterization-of-gnrh-lh-responsive-primary-aldosteronism
#5
Nadia Gagnon, Katia Caceres, Gilles Corbeil, Nada El Ghorayeb, Natasha Ludwig, Mathieu Latour, André Lacroix, Isabelle Bourdeau
Background: Recently, somatic beta-catenin mutations (CTNNB1) identified in aldosterone-producing adenomas (APA) from 3 women, were suggested to be responsible for the aberrant overexpression of LHCGR and GNRHR in the APA. Objective: To genetically characterize patients with primary aldosteronism (PA) evaluated in vivo for GnRH/LH responsive aldosterone secretion. Method: Patients with PA were evaluated in vivo to determine the possible regulation of aldosterone secretion by GnRH or LH...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29704241/enhancement-of-mitochondrial-biogenesis-and-paradoxical-inhibition-of-lactate-dehydrogenase-mediated-by-14-3-3%C3%AE-in-oncocytomas
#6
Jie Feng, Qi Zhang, Chuzhong Li, Yang Zhou, Sida Zhao, Lichuan Hong, Qi Song, Shenyuan Yu, Chunxiu Hu, Herui Wang, Chengyuan Mao, Matthew J Shepard, Shuyu Hao, Gifty Dominah, Mitchell Sun, Hong Wan, Deric M Park, Mark R Gilbert, Guowang Xu, Zhengping Zhuang, Yazhuo Zhang
Oncocytomas represent a subset of benign pituitary adenomas that are characterized by significant mitochondrial hyperplasia. Mitochondria are key organelles for energy generation and metabolic intermediate production for biosynthesis in tumor cells, so understanding the mechanism underlying mitochondrial biogenesis and its impact on cellular metabolism in oncocytoma is imperative. Here we studied surgically resected pituitary oncocytomas using multi-omic analyses. Whole-exome sequencing did not detect any nuclear mutations but identified several somatic mutations of mitochondrial DNA (mtDNA), and dysfunctional respiratory complex I...
April 27, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29691619/quantitative-multiparametric-mr-analysis-of-small-renal-lesions-correlation-with-surgical-pathology
#7
Motoyo Yano, Kathryn J Fowler, Santip Srisuwan, Amber Salter, Cary L Siegel
PURPOSE: The purpose of the study is to evaluate the utility of apparent diffusion coefficient (ADC), chemical shift signal intensity index (SII), and contrast enhancement in distinguishing between benign lesions and renal cell carcinoma (RCC) and between subtypes of renal lesions. METHODS: This retrospective study included 98 renal lesions (≤ 3 cm) on MRI with correlative surgical pathology. Scanner field strength, lesion location, and size were recorded. Two readers blinded to surgical pathology independently measured ADC ratio (ADC lesion/ADC non-lesion kidney), SII, and absolute/relative enhancement in the corticomedullary and nephrographic phases of contrast...
April 24, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29685536/a-subjective-and-objective-comparison-of-tissue-contrast-and-imaging-artifacts-present-in-routine-spin-echoes-and-in-iterative-decomposition-of-asymmetric-spin-echoes-for-soft-tissue-neck-mri
#8
Subhendra N Sarkar, David B Hackney, Robert L Greenman, Behroze A Vachha, Emelia A Johnson, Sue Nagle, Gul Moonis
OBJECTIVE: FSE sequences play key roles in neck MRI despite the susceptibility issues in neck region. Iterative decomposition of asymmetric echoes (IDEAL, GE) is a promising method that separates fat and water images resulting in high SNR and improved fat suppression. We tested how neck tissue contrasts, image artifacts and fat separation as opposed to fat suppression in terms of image quality compare between routine and IDEAL FSE. METHODS: IDEAL based and routine T1 and T2 -weighted FSE sequences were applied for neck MRI at 1...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#9
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#10
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29666728/a-rare-benign-tumor-in-a-14-year-old-girl
#11
Meral Hassan Abualjadayel, Osama Y Safdar, Maysaa Adnan Banjari, Sherif El Desoky, Ghadeer A Mokhtar, Raed A Azhar
Background: Oncocytomas are the second most common benign renal neoplasm but, unfortunately, they are difficult to differentiate from renal cell carcinoma. Renal oncocytomas are rare and have mostly been reported in adults. To our knowledge, this is only the sixth pediatric reported case of renal oncocytoma worldwide. Case Presentation: A 14-year-old Yemeni girl with a recurrent history of urinary tract infections came to our clinic complaining of left flank pain with a frontal headache...
2018: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29629865/clinicopathological-significance-of-galectin-1-expression-and-percentage-of-galectin-1-expressing-t-cells-in-clear-cell-renal-cell-carcinoma
#12
Yajuan Su, Wentao Wang, Yongpeng Xu, Wei Liangjun, Yanjie Wang, Changfu Li, Lichen Teng
INTRODUCTION: This study investigates clinical significance of galectin-1 expression in carcinoma tissues, plasma, and lymphocytes of patients with clear-cell renal cell carcinoma (RCC). METHODS: Galectin-1 expression was investigated, using immunohistochemistry, in 91 clear-cell RCC tissue sections, five angioleiolipomas tissue sections, and three oncocytomas tissue sections. As controls, normal tissue sections adjacent to each tumour and six benign renal tumour sections were examined...
March 25, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29622111/imaging-of-benign-neoplastic-and-nonneoplastic-salivary-gland-tumors
#13
REVIEW
Daniel Thomas Ginat
This article reviews the multimodality diagnostic imaging features of benign neoplastic and nonneoplastic tumors associated with the major salivary glands. Examples of neoplastic conditions that are depicted and discussed include pleomorphic adenoma, Warthin tumor, oncocytoma, peripheral nerve sheath tumors, lipoma, and hemangiomas or hemangioendotheliomas. Examples of nonneoplastic conditions that are depicted and discussed include ranulas, benign lymphoepithelial lesions, Kimura disease, and vascular malformations...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29606371/characterization-of-small-4cm-solid-renal-masses-by-computed-tomography-and-magnetic-resonance-imaging-current-evidence-and-further-development
#14
N Schieda, R S Lim, M D F McInnes, I Thomassin, R Renard-Penna, S Tavolaro, F H Cornelis
Diagnosis of renal cell carcinomas (RCC) subtypes on computed tomography (CT) and magnetic resonance imaging (MRI) is clinically important. There is increased evidence that confident imaging diagnosis is now possible while standardization of the protocols is still required. Fat-poor angiomyolipoma show homogeneously increased unenhanced attenuation, homogeneously low signal on T2-weighted MRI and apparent diffusion coefficient (ADC) map, may contain microscopic fat and are classically avidly enhancing. Papillary RCC are also typically hyperattenuating and of low signal on T2-weighted MRI and ADC map; however, their gradual progressive enhancement after intravenous administration of contrast material is a differentiating feature...
March 30, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29606134/tgr5-expression-in-normal-kidney-and-renal-neoplasms
#15
Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang, Weibiao Cao
BACKGROUND: The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 is found in a wide variety of tissues including the kidney. However, the patterns of TGR5 expression have not been well characterized in physiologic kidney or renal neoplasms. We explore the expression of TGR5 in benign renal tissue and renal neoplasms and assess its utility as a diagnostic marker...
April 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29599620/vanishing-parotid-tumors-on-mr-imaging
#16
Eiji Matsusue, Yoshio Fujihara, Eiken Matsuda, Yusuke Tokuyasu, Shu Nakamoto, Kazuhiko Nakamura, Toshihide Ogawa
Background: Of all parotid gland tumors, only oncocytoma has been reported to appear isointense to the parotid gland, namely vanishing, on fat-saturated T2 and T1 postcontrast gadolinium-enhanced magnetic resonance imaging (MRI). The purpose of this study was to evaluate vanishing of parotid tumors on conventional MRI with and/or without postcontrast gadolinium-enhancement and on diffusion weighted imaging (DWI). Methods: In 8 of 51 patients, ten parotid gland tumors had homogeneously enhanced lesions and were retrospectively analysed...
March 2018: Yonago Acta Medica
https://www.readbyqxmd.com/read/29549624/microrna-15a-expression-measured-in-urine-samples-as-a-potential-biomarker-of-renal-cell-carcinoma
#17
Yulian Mytsyk, Victor Dosenko, Yuriy Borys, Askold Kucher, Katarina Gazdikova, Dietrich Busselberg, Martin Caprnda, Peter Kruzliak, Ammad Ahmad Farooqi, Manyuk Lubov
INTRODUCTION: Currently, there is no accurate diagnostic molecular biomarker for renal cell carcinoma (RCC). The aim of this study was to assess the expression of microRNA-15a (miR-15a) in urine of patients with RCC and to evaluate its potential as a diagnostic molecular biomarker. MATERIALS AND METHODS: In total, 67 patients with solid renal tumors were enrolled: clear-cell RCC (ccRCC, n = 22), papillary RCC (pRCC, n = 16), chromophobe RCC (chRCC, n = 14), oncocytoma (n = 8), papillary adenoma (n = 2) and angiomyolipoma (n = 5)...
March 16, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29523610/nasal-oncocytoma-causing-unilateral-epiphora-in-an-elderly-patient-the-vital-role-of-nasendoscopy
#18
Declan C Murphy, Mohamed Alfiky, Peter Prinsley
Oncocytomas are rare glandular tumours, typically found in salivary glands and kidneys. A 76-year-old man presented to an ophthalmology department after 3 months of persistent right-sided epiphora. Lacrimal syringing and a fluorescein dye test demonstrated an obstruction at the level of the nasolacrimal duct (NLD). Owing to the patient's history of dacryocystitis, endoscopic dacryocystorhinostomy was organised. When in theatre however, nasendoscopy identified a polypoid mass at the lateral aspect of the inferior turbinate, obstructing the right NLD opening...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29520425/differentiating-papillary-type-i-rcc-from-clear-cell-rcc-and-oncocytoma-application-of-whole-lesion-volumetric-adc-measurement
#19
Anna K Paschall, S Mojdeh Mirmomen, Rolf Symons, Amir Pourmorteza, Rabindra Gautam, Amil Sahai, Andrew J Dwyer, Maria J Merino, Adam R Metwalli, W Marston Linehan, Ashkan A Malayeri
PURPOSE: To determine whether objective volumetric whole-lesion apparent diffusion coefficient (ADC) distribution analysis improves upon the capabilities of conventional subjective small region-of-interest (ROI) ADC measurements for prediction of renal cell carcinoma (RCC) subtype. METHODS: This IRB-approved study retrospectively enrolled 55 patients (152 tumors). Diffusion-weighted imaging DWI was acquired at b values of 0, 250, and 800 s/mm2 on a 1.5T system (Aera, Siemens Healthcare)...
March 8, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29500747/welcoming-the-new-who-classification-of-pituitary-tumors-2017-revolution-in-ttf-1-positive-posterior-pituitary-tumors
#20
REVIEW
Makoto Shibuya
The fourth edition of the World Health Organization classification of endocrine tumors (EN-WHO2017) was released in 2017. In this new edition, changes in the classification of non-neuroendocrine tumors are proposed particularly in tumors arising in the posterior pituitary. These tumors are a distinct group of low-grade neoplasms of the sellar region that express thyroid transcription factor-1, and include pituicytoma, granular cell tumor of the sellar region, spindle cell oncocytoma, and sellar ependymoma. This short review focuses on the classification of posterior pituitary tumors newly proposed in EN-WHO2017, and controversies in their pathological differential diagnosis are discussed based on recent cases...
April 2018: Brain Tumor Pathology
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