Masahito Hoki, Yosuke Yamada, Emi Hiratomo, Masahiro Hirata, Yasuhide Takeuchi, Masayoshi Yoshimatsu, Masahiro Kikuchi, Yo Kishimoto, Alexander Marx, Hironori Haga
PURPOSE: Salivary gland tumors are histologically diverse. Ionocytes and tuft cells, rare epithelial cells found in normal salivary glands, might be associated with salivary tumors. Here, we explored the expression of FOXI1 and POU2F3, master regulators of ionocytes and tuft cells, respectively, for common salivary neoplasms using immunohistochemistry. METHODS: We analyzed normal salivary tissues and nine salivary gland tumors; Warthin tumors (WT), pleomorphic adenomas (PA), basal cell adenomas, and oncocytomas were benign, whereas mucoepidermoid, adenoid cystic, acinic cell, salivary duct carcinomas, and polymorphous adenocarcinomas were malignant...
February 15, 2024: Discover. Oncology