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Tumor endothelial marker 8

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https://www.readbyqxmd.com/read/29927438/-pituitary-lactotroph-adenomas-resistant-to-dopamine-agonist-treatment-histological-and-immunohistochemical-characteristics
#1
N S Fedorova, A Yu Abrosimov, L K Dzeranova, E A Pigarova, I I Dedov
OBJECTIVE: To present the histological and immunohistochemical characteristics of pituitary lactotroph adenomas (PLAs) resistant to dopamine agonist treatment. SUBJECT AND METHODS: The investigators examined paraffin-embedded blocks and histological sections obtained from 19 patients (13 women, 6 men), whose median age was 29 (19, 38) years, after surgical treatment (adenomectomy) for PLAs resistant to dopamine agonist treatment. Immunohistological examination was performed using antibodies against prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), type 2 dopamine receptors (DR2 ), estrogen receptors-α (ERα), the proliferation marker Ki-67, and the endothelial cell marker CD34...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29890464/znf750-inhibited-the-malignant-progression-of-oral-squamous-cell-carcinoma-by-regulating-tumor-vascular-microenvironment
#2
Li Pan, Hongli Yang, Cong Xu, Shuangfeng Chen, Zhen Meng, Keyi Li, Haiying Chen
OBJECTIVE: Squamous cell carcinoma is often associated with the deletion or mutation of zinc finger protein 750 (ZNF750), its deletion or mutation is associated with squamous epithelial malignant biological characteristics. The present study is to explore the mechanism of ZNF750 to suppress the tumor malignant process by regulation tumor microenvironment. METHODS: To evaluate the changes of tumor microenvironment in oral squamous cells carcinoma cell line CAL-27 cell, the expression of angiogenin, vascular endothelial growth factor (VEGF), prolyl hydroxylase 2 (PHD2), G protein signal regulated protein 5 (RGS5), integrin A5 (ITGA5), integrin B1 (ITGB1) and CD44 were detected by Western-blot...
June 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29872287/blood-mcp-1-levels-are-increased-in-chronic-obstructive-pulmonary-disease-patients-with-prevalent-emphysema
#3
Antonino Di Stefano, Teresa Coccini, Elisa Roda, Cinzia Signorini, Bruno Balbi, Giuseppe Brunetti, Piero Ceriana
Background and aims: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by different phenotypes with either bronchial airways alterations or emphysema prevailing. As blood biomarkers could be clinically useful for COPD stratification, we aimed at investigating the levels of blood biomarkers in COPD patients differentiated by phenotype: prevalent chronic airway disease versus emphysema. Methods: In 23 COPD patients with prevalent airway disease (COPD-B), 22 COPD patients with prevalent emphysema (COPD-E), 9 control smokers (CSs), and 18 control nonsmokers (CNSs), we analyzed the expression levels of interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, epidermal growth factor (EGF), monocyte chemotactic protein (MCP)-1, and vascular endothelial growth factor by enzyme-linked immunosorbent assay in plasma/serum; glutathione peroxidase and superoxide dismutase (SOD)-1 by immunochemical kits in plasma; and free F2-isoprostanes (F2-IsoPs) by gas chromatography in plasma...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29863500/tumor-stroma-targeted-antibody-drug-conjugate-triggers-localized-anticancer-drug-release
#4
Christopher Szot, Saurabh Saha, Xiaoyan M Zhang, Zhongyu Zhu, Mary Beth Hilton, Karen Morris, Steven Seaman, James M Dunleavey, Kuo-Sheng Hsu, Guo-Jun Yu, Holly Morris, Deborah A Swing, Diana C Haines, Yanping Wang, Jennifer Hwang, Yang Feng, Dean Welsch, Gary DeCrescenzo, Amit Chaudhary, Enrique Zudaire, Dimiter S Dimitrov, Brad St Croix
Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for improved cancer therapy are needed. Here, we describe a potent MMAE-linked antibody-drug conjugate (ADC) targeting tumor endothelial marker 8 (TEM8, also known as ANTXR1), a highly conserved transmembrane receptor broadly overexpressed on cancer-associated fibroblasts, endothelium, and pericytes. Anti-TEM8 ADC elicited potent anticancer activity through an unexpected killing mechanism we term DAaRTS (drug activation and release through stroma), whereby the tumor microenvironment localizes active drug at the tumor site...
June 4, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29848570/radium-223-dichloride-in-combination-with-vascular-endothelial-growth-factor-targeting-therapy-in-advanced-renal-cell-carcinoma-with-bone-metastases
#5
Rana R McKay, Dominick Bossé, Kathryn P Gray, M Dror Michaelson, Katherine M Krajewski, Heather A Jacene, Meghara Meghara Walsh, Joaquim Bellmunt, Mark Pomerantz, Lauren C Harshman, Toni K Choueiri
PURPOSE: This study investigates the biologic activity of radium-223 with vascular endothelial growth factor (VEGF)-targeted therapy in patients with advanced renal cell carcinoma (aRCC) and bone metastases. EXPERIMENTAL DESIGN: Fifteen treatment-naïve patients (n=15) received pazopanib 800 mg orally once-daily and 15 previously-treated patients received sorafenib 400 mg orally twice-daily. Radium-223 55 kilobecquerel/kg was administered concurrently every four weeks for up to 6 infusions in both cohorts...
May 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29751081/lifr-promotes-tumor-angiogenesis-by-up-regulating-il-8-levels-in-colorectal-cancer
#6
Hao-Xuan Wu, Xi Cheng, Xiao-Qian Jing, Xiao-Pin Ji, Xian-Ze Chen, Ya-Qi Zhang, Yong-Gang He, Kun Liu, Feng Ye, Han-Xing Sun, Hao-Ji Gao, Zi-Jia Song, Huo Wu, Xiao-Jian Zhang, Tao Zhang, Ren Zhao
Leukemia inhibitory factor receptor (LIFR) has been documented as a cancer promoter and to be present at high levels in various types of tumor tissues. In our search for molecules prognostic of colorectal cancer (CRC), we found high levels of LIFR in CRC tissue samples. Further analyses revealed that LIFR was indeed prognostic of CRC patient survival, and was associated with tumor size, lymphatic metastasis and stages. LIFR was found to promote tumor growth, metastasis and angiogenesis both in vitro and in vivo...
May 8, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29742685/the-plasma-levels-of-12-cytokines-and-growth-factors-in-patients-with-gastric-cancer
#7
Zhengyun Zou, Lianjun Zhao, Shu Su, Qin Liu, Lixia Yu, Jia Wei, Yang Yang, Juan Du, Jie Shen, Xiaoping Qian, Xiangshan Fan, Wenxian Guan, Baorui Liu
To assess the association of plasma cytokines and growth factor levels with clinical characteristics and inflammatory indices in patients with gastric cancer.Plasma samples derived from 99 gastric cancer patients were used for analysis. Levels of interferon (IFN)-γ, tumor growth factor (TGF)-β1, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, and vascular endothelial growth factor (VEGF) were measured by Luminex suspension array technology. The association between cytokine/growth factor levels and demographic/clinical characteristics was assessed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29706967/role-of-c-reactive-protein-at-sites-of-inflammation-and-infection
#8
REVIEW
Nicola R Sproston, Jason J Ashworth
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of inflammation and infection into five separate monomers, termed monomeric CRP (mCRP). CRP is synthesized primarily in liver hepatocytes but also by smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes. Evidence suggests that estrogen in the form of hormone replacement therapy influences CRP levels in the elderly...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29698330/inflammatory-markers-and-preeclampsia-a-systematic-review
#9
Kathleen Darrah Black, June Andrews Horowitz
BACKGROUND: Preeclampsia (PE), a serious and variable pregnancy complication affecting 5%-10% of the obstetric population, has an undetermined etiology, yet inflammation is concomitant with its development, particularly in relation to endothelial dysfunction. OBJECTIVE: The purpose of this systematic review was to examine the published evidence concerning an association between PE and inflammatory markers for their usefulness in the prediction or early identification of women with PE in antepartum clinical settings...
May 2018: Nursing Research
https://www.readbyqxmd.com/read/29690962/effectiveness-of-vascular-markers-immunohistochemical-stains-in-soft-tissue-sarcomas
#10
Namra Naeem, Sajid Mushtaq, Noreen Akhter, Mudassar Hussain, Usman Hassan
OBJECTIVE: To ascertain the effectiveness of IHC markers of vascular origin like CD31, CD34, FLI1 and ERG in vascular soft tissue sarcomas including angiosarcomas, Kaposi sarcomas, epithelioid hemangioendothelioma and a non-vascular soft tissue sarcoma (Epithelioid sarcoma). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from 2011 to 2017. METHODOLOGY: Diagnosed cases of angiosarcomas (n=48), epithelioid hemangioendothelioma (n=9), Kaposi sarcoma (n=9) and epithelioid sarcoma (n=20) were selected...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29678527/the-effect-of-neoadjuvant-androgen-deprivation-therapy-on-tumor-hypoxia-in-high-grade-prostate-cancer-an-18-f-miso-pet-mri-study
#11
Ismini C Mainta, Thomas Zilli, Jean-Christophe Tille, Thomas De Perrot, Jean-Paul Vallée, Franz Buchegger, Valentina Garibotto, Raymond Miralbell
PURPOSE: Tumor hypoxia is associated with radioresistance and poor prognosis after radiation therapy for prostate cancer (PCa). In this prospective pilot study, we assessed the ability of 18 F-misonidazole (18 F-MISO) positron emission tomography (PET)-magnetic resonance imaging (MRI) to detect hypoxia in high-grade PCa patients who were candidates for curative radiation therapy, and we evaluated 18 F-MISO PET-MRI modulation after 3 months of neoadjuvant androgen deprivation therapy (nADT)...
March 8, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29571109/yucca-schidigera-extract-modulates-the-lead-induced-oxidative-damage-nephropathy-and-altered-inflammatory-response-and-glucose-homeostasis-in-japanese-quails
#12
Mayada R Farag, Mahmoud Alagawany, Mohamed E Abd El-Hack, Sabry A A El-Sayed, Sarah Y A Ahmed, Dalia H Samak
The present study was conducted to explore the toxic effects of lead (Pb) on the physiological responses of Japanese quails and to investigate the potential modulatory role of Yucca schidigera extract (YSE) against these effects. 360 mature Japanese quails (at 2 months of age) were used and the experiment was lasted for 8 weeks. The birds were divided into six equal groups as follow: control (basal diet, BD), BD+Pb (100 mg/kg diet), BD+YSE (100 mg/kg diet), BD+YSE (200 mg/kg diet), BD+Pb (100 mg/kg diet) +YSE (100 mg/kg diet) and BD+ Pb (100 mg/kg diet) + YSE (200 mg/kg diet)...
July 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29532289/platelet-function-is-disturbed-by-the-angiogenesis-inhibitors-sunitinib-and-sorafenib-but-unaffected-by-bevacizumab
#13
Maudy Walraven, Marjolein Y V Homs, Astrid A M van der Veldt, Henk Dekker, Jose Koldenhof, Richard Honeywell, Arjan Barendrecht, Silvie A E Sebastian, Naomi Parr, Arnold C Koekman, Emile E Voest, Mark Roest, Suzanne J A Korporaal, Henk M W Verheul
INTRODUCTION: At the clinical introduction of antiangiogenic agents as anticancer agents, no major toxicities were expected as merely just endothelial cells (ECs) in tumors would be affected. However, several (serious) toxicities became apparent, of which underlying mechanisms are largely unknown. We investigated to what extent sunitinib (multitargeted antiangiogenic tyrosine kinase inhibitor (TKI)), sorafenib (TKI) and bevacizumab [specific antibody against vascular endothelial growth factor (VEGF)] may impair platelet function, which might explain treatment-related bleedings...
May 2018: Angiogenesis
https://www.readbyqxmd.com/read/29469063/a-study-of-serum-vascular-endothelial-growth-factor-in-infantile-hemangiomas
#14
Sanjeev Paria, Vibhu Mendiratta, Ram Chander, Anju Jain, Saurabh Mittal
Background: Though infantile hemangiomas are the most common benign tumor of infancy, their etiopathogenesis is not fully understood. Some studies report a diagnostic role for vascular endothelial growth factor (VEGF), but such studies are lacking from India. Aims: To study the clinicoepidemiological profile of infantile hemangiomas, to estimate and compare the serum levels of VEGF in infantile hemangiomas and controls, and to determine correlations between serum levels of VEGF and growth characteristics of infantile hemangiomas...
February 21, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29451701/phase-1b-study-of-pasireotide-everolimus-and-selective-internal-radioembolization-therapy-for-unresectable-neuroendocrine-tumors-with-hepatic-metastases
#15
Hyun S Kim, Walid L Shaib, Chao Zhang, Ganji Purnachandra Nagaraju, Christina Wu, Olatunji B Alese, Zhengjia Chen, Edith Brutcher, Meredith Renfroe, Bassel F El-Rayes
BACKGROUND: Neuroendocrine tumors (NETs) metastasize to the liver. Everolimus and selective internal radioembolization (SIRT) are approved treatments. Pasireotide is a somatostatin analogue with an affinity for somatostatin receptors 1, 2, 3, and 5. Everolimus and pasireotide may potentiate SIRT radiosensitization and inhibit rebound angiogenesis. This study evaluated the safety of pasireotide, everolimus, and SIRT. METHODS: This 3 + 3 phase 1 trial evaluated 3 dose levels of everolimus (2...
May 1, 2018: Cancer
https://www.readbyqxmd.com/read/29444773/lung-function-inflammation-and-endothelin-1-in-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#16
Andrew Low, Sarah George, Luke Howard, Nicholas Bell, Ann Millar, Robert M R Tulloh
BACKGROUND: Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital heart disease (CHD-APAH), previously thought to be caused by worsening PAH, but perhaps also by inflammation and abnormalities of lung function. We studied lung function and airway inflammation in patients with CHD-APAH and compared the results with controls. METHODS AND RESULTS: Sixty people were recruited into the study: 20 CHD-APAH, 20 CHD controls, and 20 healthy controls...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#17
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29397265/the-evaluation-of-circulating-endothelial-progenitor-cells-and-related-angiogenic-markers-as-prognostic-factors-in-soft-tissue-tumors
#18
Ioannis Karampinis, Elena Joas, Anna Dreyer, Ulrich Ronellenfitsch, Jens Jakob, Peter Hohenberger, Kai Nowak
INTRODUCTION: Neovascularisation is a critical step in the progression of malignant tumors. Circulating endothelial progenitor cells (cEPC) have been proposed as surrogate markers of vasculogenesis in malignancies. In this project, we studied the impact of tumor-specific therapy on cEPC and associated angiogenic factors in patients with soft tissue tumors. MATERIALS AND METHODS: Fifty-three patients with soft tissue tumors (25 soft tissue sarcomas, 19 GIST, 9 desmoids) and 15 healthy controls were included...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29392318/a-novel-choroidal-endothelial-cell-line-has-a-decreased-affinity-for-the-age-related-macular-degeneration-associated-complement-factor-h-variant-402h
#19
Markus A Loeven, Jasper J van Gemst, Carolien M S Schophuizen, Viranga Tilakaratna, Lambert P van den Heuvel, Anthony J Day, B Jeroen Klevering, Johan van der Vlag
Purpose: Choroidal endothelial cells play a central role in the pathogenesis of age-related macular degeneration (AMD). Protocols for isolating primary choroidal endothelial cells have been described but require access to human donor eyes, which is a limiting factor. Therefore, a conditionally immortalized choroidal endothelial cell (ciChEnC) line has been established. Methods: Choroidal endothelial cells were selected by magnetic-activated cell sorting and conditionally immortalized using temperature-sensitive simian virus 40 large T antigen and human telomerase...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29389738/effects-of-angiotensin-converting-enzyme-inhibition-and-alpha-1-adrenergic-receptor-blockade-on-inflammation-and-hemostasis-in-human-hypertension
#20
Mikael Ekholm, Andreas Jekell, N Håkan Wallén, Bruna Gigante, Thomas Kahan
Drugs blocking the renin-angiotensin-aldosterone system may offer benefit on endothelial function, inflammation, and hemostasis in addition to the effects of reducing blood pressure. We examined the contribution of the angiotensin-converting enzyme inhibitor ramipril and the alpha 1-adrenergic receptor blocker doxazosin on blood pressure and on markers of inflammation and hemostasis in 59 individuals with mild-to-moderate hypertension randomized to receive double-blind ramipril 10 mg od or doxazosin 8 mg od for 12 weeks...
April 2018: Journal of Cardiovascular Pharmacology
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