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https://www.readbyqxmd.com/read/29571109/yucca-schidigera-extract-modulates-the-lead-induced-oxidative-damage-nephropathy-and-altered-inflammatory-response-and-glucose-homeostasis-in-japanese-quails
#1
Mayada R Farag, Mahmoud Alagawany, Mohamed E Abd El-Hack, Sabry A A El-Sayed, Sarah Y A Ahmed, Dalia H Samak
The present study was conducted to explore the toxic effects of lead (Pb) on the physiological responses of Japanese quails and to investigate the potential modulatory role of Yucca schidigera extract (YSE) against these effects. 360 mature Japanese quails (at 2 months of age) were used and the experiment was lasted for 8 weeks. The birds were divided into six equal groups as follow: control (basal diet, BD), BD+Pb (100 mg/kg diet), BD+YSE (100 mg/kg diet), BD+YSE (200 mg/kg diet), BD+Pb (100 mg/kg diet) +YSE (100 mg/kg diet) and BD+ Pb (100 mg/kg diet) + YSE (200 mg/kg diet)...
March 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29532289/platelet-function-is-disturbed-by-the-angiogenesis-inhibitors-sunitinib-and-sorafenib-but-unaffected-by-bevacizumab
#2
Maudy Walraven, Marjolein Y V Homs, Astrid A M van der Veldt, Henk Dekker, Jose Koldenhof, Richard Honeywell, Arjan Barendrecht, Silvie A E Sebastian, Naomi Parr, Arnold C Koekman, Emile E Voest, Mark Roest, Suzanne J A Korporaal, Henk M W Verheul
INTRODUCTION: At the clinical introduction of antiangiogenic agents as anticancer agents, no major toxicities were expected as merely just endothelial cells (ECs) in tumors would be affected. However, several (serious) toxicities became apparent, of which underlying mechanisms are largely unknown. We investigated to what extent sunitinib (multitargeted antiangiogenic tyrosine kinase inhibitor (TKI)), sorafenib (TKI) and bevacizumab [specific antibody against vascular endothelial growth factor (VEGF)] may impair platelet function, which might explain treatment-related bleedings...
March 12, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29469063/a-study-of-serum-vascular-endothelial-growth-factor-in-infantile-hemangiomas
#3
Sanjeev Paria, Vibhu Mendiratta, Ram Chander, Anju Jain, Saurabh Mittal
Background: Though infantile hemangiomas are the most common benign tumor of infancy, their etiopathogenesis is not fully understood. Some studies report a diagnostic role for vascular endothelial growth factor (VEGF), but such studies are lacking from India. Aims: To study the clinicoepidemiological profile of infantile hemangiomas, to estimate and compare the serum levels of VEGF in infantile hemangiomas and controls, and to determine correlations between serum levels of VEGF and growth characteristics of infantile hemangiomas...
February 21, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29451701/phase-1b-study-of-pasireotide-everolimus-and-selective-internal-radioembolization-therapy-for-unresectable-neuroendocrine-tumors-with-hepatic-metastases
#4
Hyun S Kim, Walid L Shaib, Chao Zhang, Ganji Purnachandra Nagaraju, Christina Wu, Olatunji B Alese, Zhengjia Chen, Edith Brutcher, Meredith Renfroe, Bassel F El-Rayes
BACKGROUND: Neuroendocrine tumors (NETs) metastasize to the liver. Everolimus and selective internal radioembolization (SIRT) are approved treatments. Pasireotide is a somatostatin analogue with an affinity for somatostatin receptors 1, 2, 3, and 5. Everolimus and pasireotide may potentiate SIRT radiosensitization and inhibit rebound angiogenesis. This study evaluated the safety of pasireotide, everolimus, and SIRT. METHODS: This 3 + 3 phase 1 trial evaluated 3 dose levels of everolimus (2...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29444773/lung-function-inflammation-and-endothelin-1-in-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#5
Andrew Low, Sarah George, Luke Howard, Nicholas Bell, Ann Millar, Robert M R Tulloh
BACKGROUND: Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital heart disease (CHD-APAH), previously thought to be caused by worsening PAH, but perhaps also by inflammation and abnormalities of lung function. We studied lung function and airway inflammation in patients with CHD-APAH and compared the results with controls. METHODS AND RESULTS: Sixty people were recruited into the study: 20 CHD-APAH, 20 CHD controls, and 20 healthy controls...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#6
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29397265/the-evaluation-of-circulating-endothelial-progenitor-cells-and-related-angiogenic-markers-as-prognostic-factors-in-soft-tissue-tumors
#7
Ioannis Karampinis, Elena Joas, Anna Dreyer, Ulrich Ronellenfitsch, Jens Jakob, Peter Hohenberger, Kai Nowak
INTRODUCTION: Neovascularisation is a critical step in the progression of malignant tumors. Circulating endothelial progenitor cells (cEPC) have been proposed as surrogate markers of vasculogenesis in malignancies. In this project, we studied the impact of tumor-specific therapy on cEPC and associated angiogenic factors in patients with soft tissue tumors. MATERIALS AND METHODS: Fifty-three patients with soft tissue tumors (25 soft tissue sarcomas, 19 GIST, 9 desmoids) and 15 healthy controls were included...
January 31, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29392318/a-novel-choroidal-endothelial-cell-line-has-a-decreased-affinity-for-the-age-related-macular-degeneration-associated-complement-factor-h-variant-402h
#8
Markus A Loeven, Jasper J van Gemst, Carolien M S Schophuizen, Viranga Tilakaratna, Lambert P van den Heuvel, Anthony J Day, B Jeroen Klevering, Johan van der Vlag
Purpose: Choroidal endothelial cells play a central role in the pathogenesis of age-related macular degeneration (AMD). Protocols for isolating primary choroidal endothelial cells have been described but require access to human donor eyes, which is a limiting factor. Therefore, a conditionally immortalized choroidal endothelial cell (ciChEnC) line has been established. Methods: Choroidal endothelial cells were selected by magnetic-activated cell sorting and conditionally immortalized using temperature-sensitive simian virus 40 large T antigen and human telomerase...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29389738/the-effects-of-angiotensin-converting-enzyme-inhibition-and-alpha-1-adrenergic-receptor-blockade-on-inflammation-and-hemostasis-in-human-hypertension
#9
M Ekholm, A Jekell, N H Wallén, B Gigante, T Kahan
Drugs blocking the renin-angiotensin-aldosterone system may offer benefit on endothelial function, inflammation, and hemostasis in addition to the effects of reducing blood pressure. We examined the contribution of the angiotensin converting enzyme inhibitor ramipril and the alpha 1-adrenergic receptor blocker doxazosin on blood pressure and on markers of inflammation and hemostasis in 59 individuals with mild-to-moderate hypertension randomized to receive double blind ramipril 10 mg od or doxazosin 8 mg od for 12 weeks...
January 30, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29387865/rage-aptamer-attenuates-the-growth-and-liver-metastasis-of-malignant-melanoma-in-nude-mice
#10
Nobutaka Nakamura, Takanori Matsui, Yuji Ishibashi, Ami Sotokawauchi, Kei Fukami, Yuichiro Higashimoto, Sho-Ichi Yamagishi
Epidemiological studies have suggested the link between cumulative diabetic exposure and cancer. Interaction of advanced glycation end products (AGEs) with their receptor (RAGE) may contribute to the phenomenon. We examined here the effects of DNA aptamer raised against RAGE (RAGE-aptamer) on growth and liver metastasis of G361 melanoma in nude mice. Malignant melanoma cells were intradermally injected into the upper flank region of nude mice, which received continuous administration of RAGE-aptamer (38.4 pmol/day/g body weight) or vehicle intraperitoneally by an osmotic pump up to 42 days...
November 6, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/29373859/urine-arsenic-and-arsenic-metabolites-in-u-s-adults-and-biomarkers-of-inflammation-oxidative-stress-and-endothelial-dysfunction-a-cross-sectional-study
#11
Shohreh F Farzan, Caitlin G Howe, Michael S Zens, Thomas Palys, Jacqueline Y Channon, Zhigang Li, Yu Chen, Margaret R Karagas
BACKGROUND: Arsenic (As) exposure has been associated with increased risk for cardiovascular disease (CVD) and with biomarkers of potential CVD risk and inflammatory processes. However, few studies have evaluated the effects of As on such biomarkers in U.S. populations, which are typically exposed to low to moderate As concentrations. OBJECTIVES: We investigated associations between As exposures and biomarkers relevant to inflammation, oxidative stress, and CVD risk in a subset of participants from the New Hampshire Health Study, a population with low to moderate As exposure ( n =418)...
December 15, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29323210/anticancer-potentiality-of-lignan-rich-fraction-of-six-flaxseed-cultivars
#12
Shahira M Ezzat, Samia A Shouman, Abeer Elkhoely, Yasmin M Attia, Mohamed S Elsesy, Amira S El Senousy, Mouchira A Choucry, Sabah H El Gayed, Abeer A El Sayed, Essam Abdel Sattar, Nebal El Tanbouly
The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar Giza 9 (PFH-G9) contains the highest concentration of SDG (81.64 mg/g). The in vitro cytotoxic potentiality of PFH's of six flaxseed cultivars was screened against a panel of human cancer cell lines...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303078/molecular-adjuvants-based-on-plasmids-encoding-protein-aggregation-domains-affect-bone-marrow-niche-homeostasis
#13
Maria Giovanna Sabbieti, Giovanna Lacava, Andrea Amaroli, Luigi Marchetti, Roberta Censi, Piera Di Martino, Dimitrios Agas
BACKGROUND: During last years, DNA vaccine immunogenicity has been optimized by the employment of co-stimulatory molecules and molecular adjuvants. It has been reported that plasmid (pATRex), encompassing the DNA sequence for the von Willebrand A (vWA/A) domain of the Anthrax Toxin Receptor-1 (ANTXR-1, alias TEM8, Tumor Endothelial Marker 8), acts as strong immune adjuvant by inducing formation of insoluble intracellular aggregates. Markedly, we faced with upsetting findings regarding the safety of pATRex as adjuvant since the aggregosome formation prompted to osteopenia in mice...
February 1, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29289482/the-correlation-between-hif-1-alpha-and-vegf-in-oral-squamous-cell-carcinomas-expression-patterns-and-quantitative-immunohistochemical-analysis
#14
Li-Tzu Lee, Yong-Kie Wong, Man-Yee Chan, Kuo-Wei Chang, Shyh-Chang Chen, Chiou-Tuz Chang, John Wang
BACKGROUND: The prognostic predict biomarkers are important in oral squamous cell carcinoma (OSCC). We investigated the expression patterns and quantitation of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in OSCC patients. Among OSCC patients with recurrence and metastasis, the expression percentages of HIF-1α and VEGF also were analyzed. METHODS: Thirty-eight patients (8 hyperkeratosis, 30 oral squamous cell carcinoma) were included in this study...
April 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29276854/the-impact-of-physical-activity-on-serum-inflammatory-markers-in-overweight-pubertal-boys-24-month-follow-up-study
#15
Liina Remmel, Vallo Tillmann, Eva Mengel, Pille Kool, Priit Purge, Evelin Lätt, Jaak Jürimäe
PURPOSE: To investigate the differences in the pattern of changes in serum inflammatory cytokines measured annually over a 24-month period, between less active and more active overweight boys. PARTICIPANTS/METHODS: In total, 25 pubertal overweight boys were divided by their moderate to vigorous physical activity (MVPA) levels into 2 groups: less active group (LAG; n = 10; MVPA < 60 min/d) and more active group (MAG; n = 15; MVPA > 60 min/d)...
December 23, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29274587/cardioprotective-effects-of-total-flavonoids-from-jinhe-yangxin-prescription-by-activating-the-pi3k-akt-signaling-pathway-in-myocardial-ischemia-injury
#16
Yangang Cheng, Jinyan Tan, Huifeng Li, Xiangpeng Kong, Yan Liu, Rui Guo, Guoyan Li, Bingyou Yang, Miaorong Pei
The purpose of the present study was to investigate the cardioprotective effects of total flavonoids of Jinhe yangxin prescription (JHTF) on myocardial ischemia (MI) injury rats induced by Isoproterenol (ISO) and explore the potential mechanisms underlying these effects. 128 male rats were randomized into 8 groups: Control, Model, Positive, JHTF-H (2.64 g/kg/d), JHTF-M (1.32 g/kg/day), JHTF-L (0.66 g/kg/d), LY + JHTF (JHTF-H plus LY294002, an inhibitor of PI3K/Akt) and LY groups. Electrocardiogram, histopathological examination and terminal deoxynucleotidyl transferase dUTP nickend labeling (TUNEL) assay were performed...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29228087/analysis-of-angiogenesis-biomarkers-for-ramucirumab-efficacy-in-patients-with-metastatic-colorectal-cancer-from-raise-a-global-randomized-double-blind-phase-iii-study
#17
J Tabernero, R R Hozak, T Yoshino, A L Cohn, R Obermannova, G Bodoky, R Garcia-Carbonero, T-E Ciuleanu, D C Portnoy, J Prausová, K Muro, R W Siegel, R J Konrad, H Ouyang, S A Melemed, D Ferry, F Nasroulah, E Van Cutsem
Background: The phase III RAISE trial (NCT01183780) demonstrated that the vascular endothelial growth factor (VEGF) receptor (VEGFR)-2 binding monoclonal antibody ramucirumab plus 5-fluororuracil, leucovorin, and irinotecan (FOLFIRI) significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo+FOLFIRI as second-line metastatic colorectal cancer (mCRC) treatment. To identify patients who benefit the most from VEGFR-2 blockade, the RAISE trial design included a prospective and comprehensive biomarker program that assessed the association of biomarkers with ramucirumab efficacy outcomes...
December 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29190776/large-scale-identification-of-human-cerebrovascular-proteins-inter-tissue-and-intracerebral-vascular-protein-diversity
#18
Soo Jung Lee, Soonhyung Kwon, John R Gatti, Ejona Korcari, Ty E Gresser, Princess C Felix, Simon G Keep, Kevin C Pasquale, Tongxu Bai, Sabrina A Blanchett-Anderson, Nancy W Wu, Charissa Obeng-Nyarko, Kossi M Senagbe, Kathy C Young, Snehaa Maripudi, Bharath C Yalavarthi, Dajana Korcari, Andre Y Liu, Benjamin C Schaffler, Richard F Keep, Michael M Wang
The human cerebrovascular system is responsible for regulating demand-dependent perfusion and maintaining the blood-brain barrier (BBB). In addition, defects in the human cerebrovasculature lead to stroke, intracerebral hemorrhage, vascular malformations, and vascular cognitive impairment. The objective of this study was to discover new proteins of the human cerebrovascular system using expression data from the Human Protein Atlas, a large-scale project which allows public access to immunohistochemical analysis of human tissues...
2017: PloS One
https://www.readbyqxmd.com/read/29158813/vascularized-tissue-engineered-model-for-studying-drug-resistance-in-neuroblastoma
#19
A Villasante, K Sakaguchi, J Kim, N K Cheung, M Nakayama, H Parsa, T Okano, T Shimizu, G Vunjak-Novakovic
Neuroblastoma is a vascularized pediatric tumor derived from neural crest stem cells that displays vasculogenic mimicry and can express a number of stemness markers, such as SOX2 and NANOG. Tumor relapse is the major cause of succumbing to this disease, and properties attributed to cancer stem-like cells (CSLC), such as drug-resistance and cell plasticity, seem to be the key mechanisms. However, the lack of controllable models that recapitulate the features of human neuroblastoma limits our understanding of the process and impedes the development of new therapies...
2017: Theranostics
https://www.readbyqxmd.com/read/29151077/weight-loss-dependent-and-independent-effects-of-moderate-calorie-restriction-on-endothelial-cell-markers-in-obesity
#20
K Korybalska, J Luczak, E Swora-Cwynar, A Kanikowska, N Czepulis, D Kanikowska, H Skalisz, A Breborowicz, M Grzymislawski, J Witowski
Endothelial cell dysfunction in obesity can be reduced by calorie restriction (CR), however it is unclear whether this benefit requires a concomitant weight loss or is it simply related to the reduced calorie intake per se. In our study serum was drawn from 41 obese women who were undergoing an 8-week dietary intervention with 15 - 30% energy deficit, and from 48 age- and sex-matched controls of normal weight. Serum was analysed for biomarkers of endothelial cell function, oxidative stress and inflammation...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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