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https://www.readbyqxmd.com/read/28514870/biomarker-profile-of-sepsis-associated-coagulopathy-using-biochip-assay-for-inflammatory-cytokines
#1
Amanda Walborn, Debra Hoppensteadt, Daneyal Syed, Michael Mosier, Jawed Fareed
Disseminated intravascular coagulation (DIC) is a major pathophysiological mechanism of sepsis and greatly increases the risk of death in septic patients. Disseminated intravascular coagulation is a complex physiological phenomenon that involves inappropriate activation of coagulation, inflammation, and endothelial processes. The purpose of this study was to analyze the levels of inflammatory cytokines in the plasma of patients with DIC in order to compare the measured levels with those from healthy individuals, draw correlations, and provide a basis for further biomarker panel development...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28489236/histologic-correlation-of-vegf-and-cox-2-expression-with-tumor-size-in-squamous-cell-carcinoma-of-the-larynx-and-hypopharynx
#2
Rodrigo Gonzalez Bonhin, Guilherme Machado de Carvalho, Alexandre Caixeta Guimarães, Vanessa Brito Rocha, Carlos Takahiro Chone, Agrício Nubiato Crespo, Eliane Maria Amstalden
The prognosis and survival of patients with laryngeal and hypopharyngeal squamous cell carcinoma (SCC) are related to the clinical staging. Tumor growth and metastasis are closely related to angiogenesis. Vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX-2) are intimately related to the angiogenic process in which the blood supply required for neoplastic evolution is ensured. Considering the contributions of VEGF and COX-2 to the formation, growth, and progression of primary tumors, as well as their metastasis, it has been thought that the expression of these two factors might be related to the size and/or aggressiveness of laryngeal and hypopharyngeal cancer...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28481870/thrombospondin-4-mediates-tgf-%C3%AE-induced-angiogenesis
#3
S Muppala, R Xiao, I Krukovets, D Verbovetsky, R Yendamuri, N Habib, P Raman, E Plow, O Stenina-Adognravi
TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-β signaling are process-and stage-dependent, and it is not uncommon that TGF-β exerts distinct and sometimes opposing effects on a disease progression depending on the stage and on the pathological changes associated with the stage. The mechanisms underlying cell- and process-specific effects of TGF-β are poorly understood...
May 8, 2017: Oncogene
https://www.readbyqxmd.com/read/28475639/establishment-of-human-metastatic-colorectal-cancer-model-in-rabbit-liver-a-pilot-study
#4
Veronica Prieto, Johannes M Ludwig, Alton B Farris, Ganji Purnachandra Nagaraju, Taoreed O Lawal, Bassel El-Rayes, Hyun S Kim
RATIONALE AND OBJECTIVES: To develop a human metastatic colorectal cancer (mCRC) model in a rabbit liver. MATERIALS AND METHODS: Immunosuppression in 4 adult New Zealand White rabbits weighing 3.5 to 4.5 kg was induced with daily subcutaneous injection of 15 mg/kg Cyclosporine A (CsA). On day 3 open mini-laparotomy was performed and 0.2 ml (1.8x105 cells) suspension of HCT-116 and HT-29 human CRC cells were injected into the left and right medial lobe respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28467796/dickkopf-related-protein-2-induces-g0-g1-arrest-and-apoptosis-through-suppressing-wnt-%C3%AE-catenin-signaling-and-is-frequently-methylated-in-breast-cancer
#5
Junhao Mu, Tianli Hui, Bianfei Shao, Lili Li, Zhenfang Du, Li Lu, Lin Ye, Shuman Li, Qianqian Li, Qian Xiao, Zhu Qiu, Yan Zhang, Jiangxia Fan, Guosheng Ren, Qian Tao, Tingxiu Xiang
Dickkopf-related protein 2 (DKK2) is one of the antagonists of Wnt/β-catenin signaling, with its downregulation reported in multiple cancers. However, how DKK2 contributes to breast tumorigenesis remains unclear. We examined its expression and promoter methylation in 10 breast tumor cell lines, 98 primary tumors, and 21 normal breast tissues. Compared with normal tissues, DKK2 was frequently silenced in breast cell lines (7/8). DKK2 promoter methylation was detected in 77.8% of cell lines and 86.7% of breast tumors; while rarely detected in normal breast tissues (19%), indicating common DKK2 methylation in breast cancer...
April 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28448210/body-composition-and-inflammatory-markers-in-pubertal-girls-comparison-between-athletes-and-non-athletic-controls
#6
Jaak Jürimäe, Kristel Võsoberg, Anna-Liisa Tamm, Katre Maasalu, Liina Remmel, Vallo Tillmann
Various inflammation parameters are increased with childhood obesity, but few comparable data are found in lean growing athletes. This study aims to characterize differences in 12 simultaneously measured inflammatory parameters between pubertal rhythmic gymnasts (RG) and untrained controls (UC), and to examine the relationship between body composition and inflammatory markers. Sixty 10-12-year-old girls were divided into RG (n = 30) and UC (n = 30). Fat mass (FM) and fat free mass (FFM) were measured by dual-energy X-ray absorptiometry...
April 27, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28437008/effects-from-metal-ion-in-tumor-endothelial-marker-8-and-anthrax-protective-antigen-biolayer-interferometry-experiment-and-molecular-dynamics-simulation-study
#7
Zhe Jia, Christine Ackroyd, Tingting Han, Vibhor Agrawal, Yinling Liu, Kenneth Christensen, Brian Dominy
One of the anthrax receptors, tumor endothelial marker 8 (TEM8), is reported to be a potential anticancer target due to its over-expression during tumor angiogenesis. To extend our BioLayer Interferometry study in PA-TEM8 binding, we present a computational approach to reveal the role of an integral metal ion on receptor structure and binding thermodynamics. We estimated the interaction energy between PA and TEM8 using computer simulation. Consistent with experimental study, computational results indicate the metal ion in TEM8 contributes significantly to the binding affinity, and PA-TEM8 binding is more favorable in the presence of Mg(2+) than Ca(2+) ...
June 5, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28376587/-epithelioid-sarcoma-with-mesothelial-and-lymphatic-endothelial-differentiation-a-clinicopathologic-analysis-of-10-cases
#8
Z Y Ke, S J Yang
Objective: To investigate the multidirectional differentiation potential in epithelioid sarcoma (ES), with special emphasis on its mesothelial and lymphatic endothelial markers expression. Methods: Ten cases of distal-type ES were included. The clinical, histological, and immunohistochemical(including mesothelial and lymphatic endothelial markers expression)features and follow-up data were evaluated. Results: The patients aged between 8 to 66 years. Five cases were male and five were female. The tumors were located at the palm (2 cases), wrist (3 cases), upper arm (2 cases), poplitealfossa (1 case), lower leg (1 case) and thigh (1 case), respectively...
April 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28344817/urinary-biomarkers-as-indicator-of-chronic-inflammation-and-endothelial-dysfunction-in-obese-adolescents
#9
Ruchi Singh, Arushi Verma, Salim Aljabari, Tetyana L Vasylyeva
BACKGROUND: Obesity is a pro-inflammatory state that may predispose patients to acute coronary syndrome characterized by chronic low grade inflammation resulting in endothelial dysfunction (ED). The aim of the study was to evaluate urinary biomarkers of inflammation and ED in adolescents with obesity. METHODS: Sixty three subjects were recruited for the study. Twenty healthy adolescents with normal body mass (NW), 14 overweight (OW), 29 obese (OA) subjects were selected...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#10
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28297758/-role-of-master-transcriptional-factor-prox-1-in-lymphatic-endothelial-differentiation-of-kaposiform-hemangioendothelioma
#11
Z Y Ke, S J Yang
Objective: To analyze the clinical and pathological features of Kaposiform hemangioendothelioma (KHE), and to investigate the role of master transcriptional factor Prox-1 in the regulation of lymphatic differentiation. Methods: Nine cases of KHE (during the period from October 2009 to June 2016) were collected with clinical and pathological data. H&E stained section review and immunohistochemietry using the Dako EnVision method were performed. Results: There were 6 female and 3 male patients with age ranging from 2 months to 8 years (median 3 years and 4 months)...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28248715/incorporating-inflammation-into-mortality-risk-in-pediatric-acute-respiratory-distress-syndrome
#12
MULTICENTER STUDY
Matt S Zinter, Benjamin E Orwoll, Aaron C Spicer, Mustafa F Alkhouli, Carolyn S Calfee, Michael A Matthay, Anil Sapru
OBJECTIVES: In pediatric acute respiratory distress syndrome, lung injury is mediated by immune activation and severe inflammation. Therefore, we hypothesized that patients with elevated pro- and anti-inflammatory cytokines would have higher mortality rates and that these biomarkers could improve risk stratification of poor outcomes. DESIGN: Multicenter prospective observational study. SETTING: We enrolled patients from five academic PICUs between 2008 and 2015...
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28165246/ultrasound-molecular-imaging-of-angiogenesis-using-vascular-endothelial-growth-factor-conjugated-microbubbles
#13
Jianjun Wang, Bin Qin, Xucai Chen, William R Wagner, Flordeliza S Villanueva
Imaging of angiogenesis receptors could provide a sensitive and clinically useful method for detecting neovascularization such as occurs in malignant tumors, and responses to antiangiogenic therapies for such tumors. We tested the hypothesis that microbubbles (MB) tagged with human VEGF121 (MBVEGF) bind to the kinase insert domain receptor (KDR) in vitro and angiogenic endothelium in vivo, and that this specific binding can be imaged on a clinical ultrasound system. In this work, targeted adhesion of MBVEGF was evaluated in vitro using a parallel plate flow system containing adsorbed recombinant human KDR...
March 6, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28114946/permeability-across-a-novel-microfluidic-blood-tumor-barrier-model
#14
Tori B Terrell-Hall, Amanda G Ammer, Jessica I G Griffith, Paul R Lockman
BACKGROUND: The lack of translatable in vitro blood-tumor barrier (BTB) models creates challenges in the development of drugs to treat tumors of the CNS and our understanding of how the vascular changes at the BBB in the presence of a tumor. METHODS: In this study, we characterize a novel microfluidic model of the BTB (and BBB model as a reference) that incorporates flow and induces shear stress on endothelial cells. Cell lines utilized include human umbilical vein endothelial cells co-cultured with CTX-TNA2 rat astrocytes (BBB) or Met-1 metastatic murine breast cancer cells (BTB)...
January 23, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28106549/the-multimerization-state-of%C3%A2-the%C3%A2-amyloid-%C3%AE-42-amyloid-peptide-governs-its-interaction-network-with%C3%A2-the%C3%A2-extracellular-matrix
#15
Romain Salza, Claire Lethias, Sylvie Ricard-Blum
The goals of this work were i) to identify the interactions of amyloid-β (Aβ)42 under monomeric, oligomeric, and fibrillar forms with the extracellular matrix (ECM) and receptors, ii) to determine the influence of Aβ42 supramolecular organization on these interactions, and iii) to identify the molecular functions, biological processes, and pathways targeted by Aβ42 in the ECM. The ECM and cell surface partners of Aβ42 and its supramolecular forms were identified with protein and glycosaminoglycan (GAG) arrays (81 molecules in triplicate) probed by surface plasmon resonance imaging...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28105226/expression-of-epidermal-growth-factor-like-domain-7-may-be-a-predictive-marker-of-the-effect-of-neoadjuvant-chemotherapy-for-locally-advanced-uterine-cervical-cancer
#16
Makoto Yamauchi, Takeshi Fukuda, Takuma Wada, Masaru Kawanishi, Kenji Imai, Reiko Tasaka, Tomoyo Yasui, Toshiyuki Sumi
Neoadjuvant chemotherapy (NAC) followed by hysterectomy may be effective for the treatment of locally advanced uterine cervical cancer and improve patient prognosis. It is important to identify markers that are able to predict whether NAC may be successful. Epidermal growth factor-like domain 7 (EGFL7) regulates vascular sprouting in blood vessel formation. In numerous types of human cancer, EGFL7 is upregulated and inhibits endothelial cell adhesion molecules, decreasing vascular tightness and, thus, increasing vascular permeability...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105105/silencing-of-hypoxia-inducible-factor-1%C3%AE-promotes-thyroid-cancer-cell-apoptosis-and-inhibits-invasion-by-downregulating-wwp2-wwp9-vegf-and-vegfr2
#17
Zhong-Yang Ding, Yun-Juan Huang, Jian-Dong Tang, Gan Li, Pan-Qiang Jiang, Hao-Tian Wu
Adaptation to hypoxia is an important process physiologically and pathologically. Hypoxia-inducible factor-1α (HIF-1α) participates in the cancer biology of numerous endocrine tumors, including their proliferation and differentiation. In the present study, the hypothesis that HIF-1α promotes tumorigenesis in thyroid cancer via upregulating angiogenesis-associated markers is investigated. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis were used to examine the expression of HIF-1α in thyroid cancer cell lines, and to detect the expression of WW domain containing E3 ubiquitin protein ligase (WWP)2, WWP9, vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) in MZ-CRC-1 and TT thyroid cancer cells...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28061766/chemotherapy-induced-sinusoidal-injury-csi-score-a-novel-histologic-assessment-of-chemotherapy-related-hepatic-sinusoidal-injury-in-patients-with-colorectal-liver-metastasis
#18
Heather L Stevenson, Mariana M Prats, Eizaburo Sasatomi
BACKGROUND: Preoperative neoadjuvant therapy for colorectal liver metastases (CRLM) is increasing in use and can lead to chemotherapy-induced damage to sinusoidal integrity, namely sinusoidal obstruction syndrome (SOS). SOS has been associated with an increased need for intraoperative blood transfusions, increased length of hospitalization post-surgery, decreased tumor response, and a shorter overall survival after resection due to liver insufficiency. It is critical for clinicians and pathologists to be aware of this type of liver injury, and for pathologists to include the status of the background, non-neoplastic liver parenchyma in their pathology reports...
January 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28058861/downregulation-of-transgelin-blocks-interleukin-8-utilization-and-suppresses-vasculogenic-mimicry-in-breast-cancer-cells
#19
Anastasia R Aikins, MiJung Kim, Bernardo Raymundo, Chan-Wha Kim
Vasculogenic mimicry (VM) is a non-classical mechanism recently described in many tumors, whereby cancer cells, rather than endothelial cells, form blood vessels. Transgelin is an actin-binding protein that has been implicated in multiple stages of cancer development. In this study, we investigated the role of transgelin in VM and assessed its effect on the expression of endothelial and angiogenesis-related genes during VM in MDA-MB-231 breast cancer cells. We confirmed the ability of MDA-MB-231 cells to undergo VM through a tube formation assay...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27995483/assessing-tumor-vascularization-as-a-potential-biomarker-of-imatinib-resistance-in-gastrointestinal-stromal-tumors-by-dynamic-contrast-enhanced-magnetic-resonance-imaging
#20
Lorena Consolino, Dario Livio Longo, Marianna Sciortino, Walter Dastrù, Sara Cabodi, Giovanni Battista Giovenzana, Silvio Aime
BACKGROUND: Most metastatic gastrointestinal stromal tumors (GISTs) develop resistance to the first-line imatinib treatment. Recently, increased vessel density and angiogenic markers were reported in GISTs with a poor prognosis, suggesting that angiogenesis is implicated in GIST tumor progression and resistance. The purpose of this study was to investigate the relationship between tumor vasculature and imatinib resistance in different GIST mouse models using a noninvasive magnetic resonance imaging (MRI) functional approach...
December 19, 2016: Gastric Cancer
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