Xiaoyun Guo, Shibin Wang, Xiandong Lin, Zuxing Wang, Yikai Dou, Yuping Cao, Yong Zhang, Xinqun Luo, Longli Kang, Ting Yu, Zhiren Wang, Yunlong Tan, Shenshen Gao, Hangxiao Zheng, Fen Zhao, Huifen Wang, Kesheng Wang, Fan Xie, Wenzhong Chen, Xingguang Luo
OBJECTIVES: Numerous genome-wide association studies have identified CACNA1C as one of the top risk genes for schizophrenia. As a necessary post-genome-wide association study (GWAS) follow-up, here, we focused on this risk gene, carefully investigated its novel risk variants for schizophrenia, and explored their potential functions. METHODS: We analyzed four independent samples (including three European and one African-American) comprising 5648 cases and 6936 healthy subjects to identify replicable single nucleotide polymorphism-schizophrenia associations...
October 1, 2023: Psychiatric Genetics