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https://www.readbyqxmd.com/read/28729304/effectiveness-of-the-management-of-major-depressive-episodes-disorder-in-adults-with-comorbid-chronic-physical-diseases-a-protocol-for-a-systematic-review-and-meta-analysis
#1
Pablo Martínez, Ariel Castro, Diego Alonso, Paul A Vöhringer, Graciela Rojas
INTRODUCTION: Depression is a global-scale public health problem, and a significant association has been established between depression and chronic physical diseases. This growing comorbidity poses a challenge to healthcare systems. We aim to assess the effectiveness of the management of major depressive episodes/disorder in adults with comorbid chronic physical diseases. METHODS AND ANALYSIS: We will conduct a systematic review and meta-analysis of randomised clinical trials...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28726059/professional-ethics-for-digital-age-psychiatry-boundaries-privacy-and-communication
#2
REVIEW
James E Sabin, Jonathan Clark Harland
PURPOSE OF REVIEW: Internet and social media use continue to expand rapidly. Many patients and psychiatrists are bringing digital technologies into the treatment process, but relatively little attention has been paid to the ethical challenges in doing this. This review presents ethical guidelines for psychiatry in the digital age. RECENT FINDINGS: Surveys demonstrate that patients are eager to make digital technologies part of their treatment. Substantial numbers search for professional and personal information about their therapists...
September 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28718394/multiple-possible-inaccuracies-cast-doubt-on-a-recent-report-suggesting-selective-serotonin-reuptake-inhibitors-to-be-toxic-and-ineffective
#3
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
According to a systematic review on the use of selective serotonin reuptake inhibitors (SSRIs) in adult depression that was recently published in BMC Psychiatry, the results of which have been widely disseminated in lay media, these drugs increase the risk for serious adverse events (SAEs) while exerting poor antidepressant efficacy. A cursory analysis, however, suggests the analysis of SAEs conducted by the authors to be marred by both methodological inaccuracies and blatant errors. After having corrected for these apparent mistakes, we conducted a sensitivity analysis in which we also accounted for a possible moderating effect of age; while this suggests SSRIs to be safe drugs in the non-elderly, they do confirm what is already known, that is, that they may enhance the risk for SAEs in the old...
July 18, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28716536/looking-at-hospitalized-persons-throughout-the-prism-of-the-handicap
#4
M Giral, B Boussat, F Lombard, S Stempfle, P François, D Pérennou
OBJECTIVE: To describe the disability status of non-selected hospitalized persons. METHODS AND FINDINGS: We conducted a cross-sectional survey to assess activity limitations of every person older than 18 years hospitalized in a regional university hospital covering all medical fields. Evaluators rated, on a scale from 0 to 4, 22 selected items of the International Classification of Functioning (ICF), covering the 6 following domains: learning and applying knowledge, general tasks and demands, communication, mobility, self-care, and interpersonal interactions and relationships...
July 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28716375/aging-and-post-intensive-care-syndrome-a-critical-need-for-geriatric-psychiatry
#5
REVIEW
Sophia Wang, Duane Allen, You Na Kheir, Noll Campbell, Babar Khan
Because of the aging of the intensive care unit (ICU) population and an improvement in survival rates after ICU hospitalization, an increasing number of older adults are suffering from long-term impairments because of critical illness, known as post-intensive care syndrome (PICS). This article focuses on PICS-related cognitive, psychological, and physical impairments and the impact of ICU hospitalization on families and caregivers. The authors also describe innovative models of care for PICS and what roles geriatric psychiatrists could play in the future of this rapidly growing population...
June 1, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28715464/impact-of-an-implicit-social-skills-training-group-in-children-with-autism-spectrum-disorder-without-intellectual-disability-a-before-and-after-study
#6
Jokthan Guivarch, Veena Murdymootoo, Sara-Nora Elissalde, Xavier Salle-Collemiche, Sophie Tardieu, Elisabeth Jouve, François Poinso
INTRODUCTION: Children with Autism Spectrum Disorders (ASDs) have problems with social skills. Social skills training groups are among the proposed therapeutic strategies, but their efficacy still needs to be evaluated. OBJECTIVE: To evaluate the efficacy of an implicit social skills training group in children with ASDs without intellectual disability. METHODS: A before-and-after study of children with ASD without intellectual disability was conducted in a child psychiatry day hospital, where they participated in an implicit group with cooperative games...
2017: PloS One
https://www.readbyqxmd.com/read/28696436/reduced-trpc6-mrna-levels-in-the-blood-cells-of-patients-with-alzheimer-s-disease-and-mild-cognitive-impairment
#7
R Lu, J Wang, R Tao, J Wang, T Zhu, W Guo, Y Sun, H Li, Y Gao, W Zhang, C J Fowler, Q Li, S Chen, Z Wu, C L Masters, C Zhong, N Jing, Y Wang, Y Wang
Transient receptor potential canonical 6 (TRPC6) inhibits β-amyloid (Aβ) production. Hyperforin, the TRPC6 agonist, reduces Aβ levels and improves cognitive performance in Alzheimer's disease (AD) models. However, it's unknown whether TRPC6 expression is changed in AD patients. In this case-control study, we measured TRPC6 expression levels in the peripheral blood cells of four independent AD sets from five hospitals and one mild cognitive impairment (MCI) set from a local community (229 AD, 70 MCI, 40 Parkinson disease and 359 controls from China, total n=698) using quantitative real-time PCR assay...
July 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28696433/elevated-plasma-ferritin-in-elderly-individuals-with-high-neocortical-amyloid-%C3%AE-load
#8
K Goozee, P Chatterjee, I James, K Shen, H R Sohrabi, P R Asih, P Dave, C ManYan, K Taddei, S J Ayton, M L Garg, J B Kwok, A I Bush, R Chung, J S Magnussen, R N Martins
Ferritin, an iron storage and regulation protein, has been associated with Alzheimer's disease (AD); however, it has not been investigated in preclinical AD, detected by neocortical amyloid-β load (NAL), before cognitive impairment. Cross-sectional analyses were carried out for plasma and serum ferritin in participants in the Kerr Anglican Retirement Village Initiative in Aging Health cohort. Subjects were aged 65-90 years and were categorized into high and low NAL groups via positron emission tomography using a standard uptake value ratio cutoff=1...
July 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28686564/asperger-syndrome-and-schizophrenia-%C3%AE-eurodevelopmental-continuum-or-separated-clinical-entities
#9
Chr Anomitri, H Lazaratou
This article is an overview of the literature on Asperger's syndrome and schizophrenia and aim to discuss their similarities and differences. Eugen Bleuler who associated the terms "schizophrenia" and "autism" a century ago, viewed autism as a form of solitude of schizophrenic patients representing withdrawal from reality. Ever since, there has been confusion as to the boundaries between these conditions. Nowadays recent research, from a variety of perspectives-genomics, neurodevelopment, psychiatry, etc. has given new information on these conditions...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28686478/impact-of-medical-comorbidity-in-psychiatric-inpatient-length-of-stay
#10
Nuno Rodrigues-Silva, Lúcia Ribeiro
BACKGROUND: Medical comorbidity is associated with worse psychiatric outcomes, reduced functioning and higher services use, including inpatient psychiatric care. AIM: We explored the relation between medical comorbidity and length of stay, adjusting for potential confounders. METHODS: We retrospectively analyzed an administrative database comprising all inpatient admissions between 2005 and 2014 at the Department of Psychiatry and Mental Health at Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia - Portugal...
July 7, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28680170/pharmacokinetic-interactions-between-valproic-acid-and-lorazepam-pivotal-study-a-review-of-site-specific-practices
#11
Joane Y Tang, Tony K L Kiang, Mary H H Ensom
BACKGROUND: Coadministration of lorazepam and valproic acid is identified by tertiary references as causing a major drug interaction that requires therapy modification and dosage adjustments. The proposed mechanism involves inhibition of lorazepam glucuronidation via direct inhibition of uridine 5'-diphosphate-glucuronosyltransferase enzymes by valproic acid. However, the clinical significance of this interaction is unclear. OBJECTIVES: To identify site-specific practices and assess clinical responses to the interaction between valproic acid and lorazepam...
May 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28678984/association-of-neural-and-emotional-impacts-of-reward-prediction-errors-with-major-depression
#12
Robb B Rutledge, Michael Moutoussis, Peter Smittenaar, Peter Zeidman, Tanja Taylor, Louise Hrynkiewicz, Jordan Lam, Nikolina Skandali, Jenifer Z Siegel, Olga T Ousdal, Gita Prabhu, Peter Dayan, Peter Fonagy, Raymond J Dolan
Importance: Major depressive disorder (MDD) is associated with deficits in representing reward prediction errors (RPEs), which are the difference between experienced and predicted reward. Reward prediction errors underlie learning of values in reinforcement learning models, are represented by phasic dopamine release, and are known to affect momentary mood. Objective: To combine functional neuroimaging, computational modeling, and smartphone-based large-scale data collection to test, in the absence of learning-related concerns, the hypothesis that depression attenuates the impact of RPEs...
July 5, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28655681/depression-and-hiv-epidemiological-and-clinical-aspects-at-the-bamako-university-hospital-mali
#13
J Zoungrana, J P Dembélé, F B Sako, S Siranyan, J Traore, A Sawadogo, A Millogo, B Coulibaly, S Dao
Depression plays an important role in clinical worsening, morbidity and mortality related to HIV/AIDS. To describe the epidemiological and clinical aspects of depressive disorders in people with HIV in Mali. This prospective study took place in the department of psychiatry and infectious diseases at the Bamako University Hospital from July 2004 through October, 2005 and included all HIV-positive antiretroviral-naive patients with depression, diagnosed according to ICD-10 criteria. The study included 84 HIV-positive patients with a depressive disorder; our total population of HIV-positive patients was 316 during the study period, for a prevalence rate of 26...
June 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28653549/sociodemographic-and-clinical-profiles-of-homeless-mentally-ill-admitted-in-mental-health-institute-of-south-india-know-the-unknown-project
#14
Guru S Gowda, G Gopika, Narayana Manjunatha, Channaveerachari Naveen Kumar, Ravi Yadav, Dwarakanath Srinivas, Bharath Rose Dawn, Suresh Bada Math
OBJECTIVES: A significant number of homeless mentally ill (HMI) patients without any personal, family or other identification details represent a unique problem in the psychiatric services of developing countries like India in the context of legal, humanitarian and treatment issues. These patients pose challenge to the mental health professional in diagnosis and management. AIMS: To study the sociodemographic and clinical profiles of HMI patients admitted under psychiatry...
June 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28647010/social-skills-training-for-children-and-adolescents-with-autism-spectrum-disorder-a-randomized-controlled-trial
#15
Nora Choque Olsson, Oskar Flygare, Christina Coco, Anders Görling, Anna Råde, Qi Chen, Katarina Lindstedt, Steve Berggren, Eva Serlachius, Ulf Jonsson, Kristiina Tammimies, Lars Kjellin, Sven Bölte
OBJECTIVE: Social skills group training (SSGT) for children and adolescents with autism spectrum disorder (ASD) is widely applied, but effectiveness in real-world practice has not yet been properly evaluated. This study sought to bridge this gap. METHOD: This 12-week pragmatic randomized controlled trial of SSGT compared to standard care alone was conducted at 13 child and adolescent psychiatry outpatient units in Sweden. Twelve sessions of manualized SSGT ("KONTAKT") were delivered by regular clinical staff...
July 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28641914/interactive-home-telehealth-and-burns-a-pilot-study
#16
Sean Hickey, Jason Gomez, Benjamin Meller, Jeffery C Schneider, Meredith Cheney, Shamim Nejad, John Schulz, Jeremy Goverman
OBJECTIVE: The objective of this study is to review our experience incorporating Interactive Home Telehealth (IHT) visits into follow-up burn care. METHODS: A retrospective review of all burn patients participating in IHT encounters over the course of 15 months was performed. Connections were established through secure video conferencing and call-routing software. Patients connected with a personal computer or tablet and providers connected with a desktop computer with a high-definition web camera...
June 19, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28639724/longitudinal-changes-in-global-and-domain-specific-cognitive-function-in-the-very-old-findings-from-the-newcastle-85-study
#17
Blossom C M Stephan, Graciela Muniz-Terrera, Antoneta Granic, Joanna Collerton, Karen Davies, Brian K Saxby, Keith A Wesnes, Thomas B L Kirkwood, Carol Jagger
OBJECTIVE: Ageing is associated with changes in cognition in some, but not all domains. In young-old adults, defined as persons aged 65-84 years, baseline cognitive function has been shown to impact on cognitive trajectories. Whether similar patterns occur in the very-old, defined as persons aged 85 years and over, is not known. METHODS: Longitudinal changes (5 years' follow-up) in global and domain specific cognitive function including memory, attention and speed were investigated in participants from the Newcastle 85+ Study (n = 845)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28639209/substance-use-and-misuse-among-children-and-youth-with-mental-illness-a%C3%A2-pilot-study
#18
V Herz, N Franzin, J Huemer, D Mairhofer, J Philipp, K Skala
OBJECTIVE: The aim of this study was to examine prevalence, patterns and predictors of substance use among a sample of adolescent psychiatric inpatients. METHODS: Participants included 25 minors aged 12-17 years admitted to an Austrian department of child and adolescent psychiatry. Lifetime use, initiation, frequency and quantity of substance use, sociodemographic, family and school-related data were collected by self-report measures. Substance use disorders were detected using CAGE (a screening instrument for problem drinking) and FTND (Fagerström Test For Nicotine Dependence)...
June 21, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28636576/vitamin-d-levels-and-vitamin-d-receptor-gene-polymorphism-in-major-depression
#19
Merve Şahin Can, Hayriye Baykan, Özgür Baykan, Nevin Erensoy, Tunay Karlıdere
BACKGROUND: The aim of this study is to evaluate vitamin D levels and rs2228570 (FokI) polymorphism of vitamin D in patients with established diagnosis of major depressive disorder in order to investigate the impact of vitamin D levels and genetic polymorphisms on etiology and/or severity of the disease. SUBJECTS AND METHODS: The study included 86 patients who were diagnosed with major depressive disorder in Hospital of Balıkesir University Faculty of Medicine, Department of Psychiatry, and 89 healthy volunteers with similar age, sex, education level and BMI...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28631372/patient-and-provider-characteristics-related-with-prescribing-of-adhd-medication-nationwide-health-insurance-claims-database-study-in-korea
#20
Inmyung Song, Mo Se Lee, Eui-Kyung Lee, Ju-Young Shin
BACKGROUND: Little is known about the association between prescribing of attention deficit hyperactivity disorder (ADHD) medication and the patient's age, gender, and type of medical institution in Asia region. INTRODUCTION: This study investigates the prevalence and factors of diagnosis and pharmacological treatment of ADHD in the pediatric population. METHODS: Using the Korea Health Insurance database, study participants were identified as pediatric patients (≤17 years) with at least 1 diagnosis of ADHD (ICD-10, F90) from January 1, 2007 to December 31, 2011...
June 20, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
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