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https://www.readbyqxmd.com/read/29038599/widespread-white-matter-microstructural-differences-in-schizophrenia-across-4322-individuals-results-from-the-enigma-schizophrenia-dti-working-group
#1
S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, O A Andreassen, C Arango, N Banaj, S Bouix, C A Bousman, R M Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, J-X Chen, X Chen, C Chiapponi, Kl K Cho, V Ciullo, A S Corvin, B Crespo-Facorro, V Cropley, P De Rossi, C M Diaz-Caneja, E W Dickie, S Ehrlich, F-M Fan, J Faskowitz, H Fatouros-Bergman, L Flyckt, J M Ford, J-P Fouche, M Fukunaga, M Gill, D C Glahn, R Gollub, E D Goudzwaard, H Guo, R E Gur, R C Gur, T P Gurholt, R Hashimoto, S N Hatton, F A Henskens, D P Hibar, I B Hickie, L E Hong, J Horacek, F M Howells, H E Hulshoff Pol, C L Hyde, D Isaev, A Jablensky, P R Jansen, J Janssen, E G Jönsson, L A Jung, R S Kahn, Z Kikinis, K Liu, P Klauser, C Knöchel, M Kubicki, J Lagopoulos, C Langen, S Lawrie, R K Lenroot, K O Lim, C Lopez-Jaramillo, A Lyall, V Magnotta, R C W Mandl, D H Mathalon, R W McCarley, S McCarthy-Jones, C McDonald, S McEwen, A McIntosh, T Melicher, R I Mesholam-Gately, P T Michie, B Mowry, B A Mueller, D T Newell, P O'Donnell, V Oertel-Knöchel, L Oestreich, S A Paciga, C Pantelis, O Pasternak, G Pearlson, G R Pellicano, A Pereira, J Pineda Zapata, F Piras, S G Potkin, A Preda, P E Rasser, D R Roalf, R Roiz, A Roos, D Rotenberg, T D Satterthwaite, P Savadjiev, U Schall, R J Scott, M L Seal, L J Seidman, C Shannon Weickert, C D Whelan, M E Shenton, J S Kwon, G Spalletta, F Spaniel, E Sprooten, M Stäblein, D J Stein, S Sundram, Y Tan, S Tan, S Tang, H S Temmingh, L T Westlye, S Tønnesen, D Tordesillas-Gutierrez, N T Doan, J Vaidya, N E M van Haren, C D Vargas, D Vecchio, D Velakoulis, A Voineskos, J Q Voyvodic, Z Wang, P Wan, D Wei, T W Weickert, H Whalley, T White, T J Whitford, J D Wojcik, H Xiang, Z Xie, H Yamamori, F Yang, N Yao, G Zhang, J Zhao, T G M van Erp, J Turner, P M Thompson, G Donohoe
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29034811/mental-illness-stigma-among-medical-students-and-teachers
#2
Miroslava Janoušková, Aneta Weissová, Tomáš Formánek, Jiří Pasz, Lucie Bankovská Motlová
BACKGROUND: Medical school curriculum contributes to future doctors' attitude formation towards people with mental illness. AIM: The purpose of this study was to compare stigmatizing attitudes between medical students and faculty, analyse stigmatizing attitudes among students from different years of study and identify factors predicting stigma. METHODS: A cross-sectional study with the use of scales measuring attitudes and social distance was designed...
October 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29033635/evaluation-of-5-httlpr-gene-polymorphism-and-resilience-components-on-the-development-of-psychopathology-in-adolescent-sexual-abuse-cases
#3
Gresa Çarkaxhiu Bulut, Ayşe Rodopman Arman, İlter Güney, Pınar Gültepe
INTRODUCTION: More than one-fourth adolescents are exposed to unexpected frightening experiences and traumas until adulthood. In this study, we aimed to determine the potential role of serotonin transporter (5-HTT) gene polymorphism regarding resilience factors in the symptom variability of individuals exposed to sexual abuse. METHODS: Adolescents aged 11-17 years, who were admitted to the Marmara University Child Psychiatry Outpatient Clinic Forensic division with sexual abuse experience history, were informed about the research, and volunteers were included in the study...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29023285/predictors-of-electroconvulsive-therapy-use-in-a-large-inpatient-psychiatry-population
#4
Julia Knight, Micaela Jantzi, John Hirdes, Terry Rabinowitz
OBJECTIVE: There is limited research on reliable and clinically useful predictors of electroconvulsive therapy (ECT) use. We aimed to examine factors that predict ECT use in an inpatient psychiatric population. DESIGN: Retrospective analysis of provincial database for inpatient psychiatry. METHODS: This study is a retrospective analysis of a provincial database for inpatient psychiatry. The study includes all psychiatric inpatients 18 years or older in Ontario, Canada, assessed with the Resident Assessment Instrument for Mental Health (RAI-MH) within the first 3 days of admission between 2009 and 2014 (n = 153,023)...
October 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29022840/irritable-temperament-and-lifetime-psychotic-symptoms-as-predictors-of-anxiety-symptoms-in-bipolar-disorder
#5
Gianluca Serafini, Pierre A Geoffroy, Andrea Aguglia, Giulia Adavastro, Giovanna Canepa, Maurizio Pompili, Mario Amore
PURPOSE: Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in BD. MATERIALS AND METHODS: We recruited at the Section of Psychiatry, Department of Neuroscience, University of Genoa (Italy), 92 BD inpatients having a mean age of 52 (±13...
October 12, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29021115/specialty-addiction-and-psychiatry-treatment-initiation-and-engagement-results-from-an-sbirt-randomized-trial-in-pediatrics
#6
Stacy Sterling, Andrea H Kline-Simon, Ashley Jones, Derek D Satre, Sujaya Parthasarathy, Constance Weisner
OBJECTIVE: Many adolescents needing specialty addiction or psychiatry treatment never access care. We examined initiation and engagement with addiction and/or psychiatry treatment among adolescents referred to treatment from a trial comparing two different modalities of delivering Screening, Brief Intervention and Referral to Treatment (SBIRT) to Usual Care in pediatric primary care. We hypothesized that both intervention arms would have higher initiation and engagement rates than usual care...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29018555/teaching-provision-for-old-age-psychiatry-in-medical-schools-in-the-uk-and-ireland-a-survey
#7
Sophia Bennett, Poppy Ilderton, John T O'Brien, John-Paul Taylor, Andrew Teodorczuk
Aims and method This work builds on a survey first done in 1999 to understand how old age psychiatry teaching is embedded in undergraduate medical schools in the UK and Ireland and the influence of academic old age psychiatrists on teaching processes. We invited deans of 31 medical schools in the UK and Ireland in 2015 to complete an online survey to reassess the situation 16 years later. Results Response rate was 74%. As found in the original survey, there was variation across medical schools in how old age psychiatry is taught...
October 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28993963/a-double-blind-placebo-controlled-randomised-trial-of-omega-3-supplementation-in-children-with-moderate-adhd-symptoms
#8
Catherine Cornu, Catherine Mercier, Tiphanie Ginhoux, Sandrine Masson, Julie Mouchet, Patrice Nony, Behrouz Kassai, Valérie Laudy, Patrick Berquin, Nathalie Franc, Marie-France Le Heuzey, Hugues Desombre, Olivier Revol
OBJECTIVE: Clinical trials and inconclusive meta-analyses have investigated the effects of omega-3 supplements in children with Attention-Deficit Hyperactivity Disorder (ADHD). We performed a randomised placebo-controlled trial to evaluate the efficacy of omega-3 fatty acids. METHODS: Children aged 6-15 years with established diagnosis of ADHD were randomised 1:1 to receive either supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or a placebo for 3 months...
October 5, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28993710/dose-dependent-expression-of-claudin-5-is-a-modifying-factor-in-schizophrenia
#9
C Greene, J Kealy, M M Humphries, Y Gong, J Hou, N Hudson, L M Cassidy, R Martiniano, V Shashi, S R Hooper, G A Grant, P F Kenna, K Norris, C K Callaghan, M dN Islam, S M O'Mara, Z Najda, S G Campbell, J S Pachter, J Thomas, N M Williams, P Humphries, K C Murphy, M Campbell
Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general population. Various genes show associations with schizophrenia and a very weak nominal association with the tight junction protein, claudin-5, has previously been identified. Claudin-5 is expressed in endothelial cells forming part of the blood-brain barrier (BBB). Furthermore, schizophrenia occurs in 30% of individuals with 22q11 deletion syndrome (22q11DS), a population who are haploinsufficient for the claudin-5 gene. Here, we show that a variant in the claudin-5 gene is weakly associated with schizophrenia in 22q11DS, leading to 75% less claudin-5 being expressed in endothelial cells...
October 10, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28992996/attention-profiles-in-childhood-absence-epilepsy-compared-with-attention-deficit-hyperactivity-disorder
#10
Hyun-Jeong Lee, Eun-Hee Kim, Mi-Sun Yum, Tae-Sung Ko, Hyo-Won Kim
OBJECTIVE: This study aimed to compare the attention profiles of subjects with childhood absence epilepsy (CAE) to those of children with attention-deficit/hyperactivity disorder (ADHD) and controls. METHOD: We retrospectively reviewed the medical records of 20 children (age 7.2 ± 1.6 years, 5 boys) in whom CAE was diagnosed at the Department of Pediatric Neurology of Asan Medical Center, Seoul, Korea. ADHD and control subjects were selected from children who visited the Department of Pediatric Psychiatry and were confirmed as having or not having ADHD based on Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL)...
October 6, 2017: Brain & Development
https://www.readbyqxmd.com/read/28990447/psychotic-like-experiences-in-help-seeking-adolescents-dimensional-exploration-and-association-with-different-forms-of-bullying-victimization-a-developmental-social-psychiatry-perspective
#11
Gennaro Catone, Roberta Marotta, Simone Pisano, Belinda Lennox, Marco Carotenuto, Antonella Gritti, Antonio Pascotto, Matthew R Broome
BACKGROUND: Psychotic-like experiences (PLEs) are common in the general population and increase the risk of psychotic disorders. Adolescents are a high-risk group of this condition. Stressful events, such as bullying, have a role in the onset of PLEs. This study has several aims: (1) to assess PLEs in adolescents seeking help from a Child and Adolescent Mental Health Service, (2) to assess the association of PLEs with specific bullying victimization and (3) to assess difference in PLEs and victimizations by sex and age...
October 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28988102/number-of-illness-episodes-as-predictor-of-residual-symptoms-in-major-depressive-disorder
#12
Gianluca Serafini, Jacopo Nebbia, Nicolò Cipriani, Claudia Conigliaro, Denise Erbuto, Maurizio Pompili, Mario Amore
Notwithstanding major depressive disorder (MDD) is a recurring and chronic condition, relatively few variables have consistently been shown to predict its course. Residual depressive symptoms may be associated with disability and functional impairment but few studies evaluated clinical correlates associated with these symptoms and their impact on functioning after adjustment for potential confounders. Therefore, our study aimed to investigate factors associated with residual depressive symptoms and their impact on the course of MDD...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28987290/medical-student-experiences-on-consultation-liaison-psychiatry-rotations-a-nationwide-survey
#13
Fremonta Meyer, Omair Abbasi, David Kasick, Kewchang Lee, Christine Pelic, Jennifer Zinser, Thomas Harris, Margo Funk
BACKGROUND: Consultation-liaison (C-L) psychiatry clerkship rotations may improve medical students' understanding of psychiatric principles relevant to the settings in which they will ultimately practice. This study aimed to characterize students' experiences on C-L rotations. METHODS: This cross-sectional survey study, sponsored by the Academy of Psychosomatic Medicine Subcommittee on Medical Student Education, was conducted at 5 US medical schools between 2012 and 2016...
August 2, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28986993/children-in-out-of-home-care-are-at-high-risk-of-somatic-dental-and-mental-ill-health
#14
L S Randsalu, L Laurell
AIM: The Swedish Social Board has implemented a support strategy to guide out-of-home care for children, which translates as children's needs in focus (CNIF) and includes a systematic health assessment. It was fully introduced into the Skåne province in 2012 and our study covered the first four years of the CNIF health assessments, from 2012-2015. METHODS: We studied children aged 0-17 years in out-of-home care who had been referred by social workers for a CNIF health assessment, using their medical records to investigate both their health and the value of the health assessments...
October 7, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28984077/broad-clinical-high-risk-mental-state-charms-methodology-of-a-cohort-study-validating-criteria-for-pluripotent-risk
#15
Jessica A Hartmann, Barnaby Nelson, Rachael Spooner, G Paul Amminger, Andrew Chanen, Christopher G Davey, Meredith McHugh, Aswin Ratheesh, Devi Treen, Hok Pan Yuen, Patrick D McGorry
AIM: The development of the ultra-high risk (UHR) criteria for psychosis created a new paradigm for the prevention research in psychiatry. Since (1) prevention research faces the challenge of achieving adequate statistical power when focusing on single low-incidence syndromes and (2) early clinical phenotypes are overlapping and non-specific, this study broadens the UHR state beyond psychosis as an outcome. The CHARMS (clinical high at-risk mental state) study aims to prospectively validate a set of trans-diagnostic criteria to identify help-seeking young people at risk of developing a range of serious mental illnesses...
October 5, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28983854/a-pilot-study-examining-factors-influencing-readiness-to-progress-to-indirect-supervision-among-first-year-residents-in-a-general-psychiatry-training-program
#16
Bryan Touchet, Ashley Walker, Sarah Flanders, Heather McIntosh
OBJECTIVE: In the first year of training, psychiatry residents progress from direct supervision to indirect supervision but factors predicting time to transition between these levels of supervision are unknown. This study aimed to examine times for transition to indirect levels of supervision and to identify resident factors associated with slower progression. METHODS: The authors compiled data from training files from years 2011-2015, including licensing exam scores, age, gender, medical school, month of first inpatient psychiatry rotation, and transition times between levels of supervision...
October 5, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28983797/clinical-factors-associated-with-decision-to-recommend-methylphenidate-treatment-for-children-with-adhd-in-france
#17
Elodie Courtabessis, Florence Pupier, Laurie Surig, Marie-Christine Picot, Erika Nogué, Valérie Macioce, Elizabeth Stein, Diane Purper-Ouakil
European guidelines advise on best practices for the diagnosis and non-pharmacological and pharmacological treatment of attention-deficit hyperactivity disorder (ADHD). This study aimed to (1) assess whether clinician's decisions to initiate methylphenidate treatment in children diagnosed with ADHD are in accordance with European guidelines and (2) identify clinical factors associated with the decision to recommend methylphenidate prescription. 5 to 13-year-old patients with an ADHD diagnosis were consecutively evaluated in an outpatient child and adolescent psychiatry clinic in France...
October 5, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28983385/can-geriatric-psychiatry-patients-complete-symptoms-self-reports-using-tablets-a-randomized-study
#18
Ghizlane Moussaoui, Ching Yu, Vincent Laliberté, Dominique Elie, Artin A Mahdanian, Benjamin Dawson, Marilyn Segal, Karl J Looper, Rej Soham
BACKGROUND: With our aging population and limited number of geriatric psychiatrists, innovations must be made in order to meet the growing demands for geriatric psychiatry services. Emerging technologies could greatly improve access to care and systematic data collection. METHODS: This randomized study compared completion rates and time to completion (primary outcomes) when using iPad technology vs. traditional paper forms to complete self-report psychiatric symptoms...
September 2017: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28971547/ten-year-prevalence-of-mental-disorders-in-patients-presenting-with-chronic-pain-in-secondary-care-a-register-linkage-cohort-study
#19
S Søndergård, H B Vaegter, A Erlangsen, E Stenager
BACKGROUND: Prevalence rates of mental disorders in patients with chronic pain vary and may be overestimated when assessed by screening instruments only. Objectives were to estimate the 10-year prevalence of different mental disorders diagnosed by psychiatrists in patients with chronic pain compared with the Danish general population. METHODS: Patients (n = 7197) consulted in the interdisciplinary Pain Clinic South at Odense University Hospital, Denmark, from 2005 to 2015 were included...
October 3, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28971456/clinical-simulation-training-in-geriatric-medicine-a-review-of-the-evidence-and-lessons-for-training-in-psychiatry-of-old-age
#20
Christos Plakiotis
Clinical simulation encompasses a broad range of methods and techniques that allow clinical skills to be rehearsed and practiced away from the clinic before being applied to real patients. As such, preparation of doctors and other healthcare professionals for safe clinical practice is one of its main aims. The objective of this paper was to review the evidence regarding the use of clinical simulation training in geriatric medicine education and consider how the findings may be translated to education in the closely related field of psychiatry of old age...
2017: Advances in Experimental Medicine and Biology
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