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https://www.readbyqxmd.com/read/29149503/sexual-functioning-among-young-adult-cancer-patients-a-2-year-longitudinal-study
#1
Chiara Acquati, Brad J Zebrack, Anna C Faul, Leanne Embry, Christine Aguilar, Rebecca Block, Brandon Hayes-Lattin, David R Freyer, Steve Cole
BACKGROUND: Cancer-related sexual dysfunction has been reported among adolescents and young adults (AYAs); however, its prevalence over time has not been examined. This longitudinal study investigated sexual dysfunction in AYAs over the course of 2 years after the initial diagnosis. METHODS: Young adult patients (18-39 years old) completed the Medical Outcomes Study Sexual Functioning Scale within the first 4 months of their diagnosis (n = 123) and again 6 (n = 107) and 24 months later (n = 95)...
November 17, 2017: Cancer
https://www.readbyqxmd.com/read/29149325/the-iuphar-bps-guide-to-pharmacology-in-2018-updates-and-expansion-to-encompass-the-new-guide-to-immunopharmacology
#2
Simon D Harding, Joanna L Sharman, Elena Faccenda, Chris Southan, Adam J Pawson, Sam Ireland, Alasdair J G Gray, Liam Bruce, Stephen P H Alexander, Stephen Anderton, Clare Bryant, Anthony P Davenport, Christian Doerig, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A Davies
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators...
November 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29148253/quantification-of-vascular-damage-in-acute-kidney-injury-with-fluorine-magnetic-resonance-imaging-and-spectroscopy
#3
Jeremy K Moore, Junjie Chen, Hua Pan, Joseph P Gaut, Sanjay Jain, Samuel A Wickline
PURPOSE: To design a fluorine MRI/MR spectroscopy approach to quantify renal vascular damage after ischemia-reperfusion injury, and the therapeutic response to antithrombin nanoparticles (NPs) to protect kidney function. METHODS: A total of 53 rats underwent 45 min of bilateral renal artery occlusion and were treated at reperfusion with either plain perfluorocarbon NPs or NPs functionalized with a direct thrombin inhibitor (PPACK:phenyalanine-proline-arginine-chloromethylketone)...
November 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29147112/do-changes-in-welfare-and-health-policy-affect-life-satisfaction-of-older-citizens-in-europe
#4
Marinela Olaroiu, Ioana Dana Alexa, Wim J A van den Heuvel
Objectives: Ageing of societies causes serious political concerns on well-being of old citizens and care for the (frail) old. These concerns increased with the economic crisis of 2008. In European countries policy measures were taken to deal with the consequences of this crisis. This study explores the possible effects of these measures on life satisfaction of older citizens. Methods: Life satisfaction was assessed through international surveys in 2007 and 2013 and changes in societal conditions, using eight indicators on demography, welfare, and health, are assessed in 31 European countries in 2006 and in 2014...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/29146093/treatment-status-and-radiographic-features-of-patients-with-atypical-femoral-fractures
#5
Hiroshi Hagino, Naoto Endo, Tetsuji Yamamoto, Atsushi Harada, Jun Iwamoto, Naoki Kondo, Tasuku Mashiba, Satoshi Mori, Junichi Nakamura, Seiji Ohtori, Akinori Sakai, Junichi Takada, Yoshiharu Kato
BACKGROUND: The Japanese Orthopaedic Association (JOA) has been surveying approximately 3000 orthopedic surgery hospitals and clinics with inpatient facilities nationwide to collect information on atypical femoral fractures (AFFs) and patient characteristics since 2010. The present study aims to examine radiographic images and clarify the relationship between radiographic and patient characteristics of patients with AFF and treatment status. METHODS: The study involved 1996 facilities certified as clinical training sites by the JOA and 912 clinics with inpatient facilities affiliated with the Japanese Clinical Orthopaedic Association (JCOA)...
November 13, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29143791/dietary-and-endogenous-sphingolipid-metabolism-in-chronic-inflammation
#6
REVIEW
Gregory H Norris, Christopher N Blesso
Chronic inflammation is a common underlying factor in many major metabolic diseases afflicting Western societies. Sphingolipid metabolism is pivotal in the regulation of inflammatory signaling pathways. The regulation of sphingolipid metabolism is in turn influenced by inflammatory pathways. In this review, we provide an overview of sphingolipid metabolism in mammalian cells, including a description of sphingolipid structure, biosynthesis, turnover, and role in inflammatory signaling. Sphingolipid metabolites play distinct and complex roles in inflammatory signaling and will be discussed...
October 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29143669/considerations-for-using-minocycline-vs-doxycycline-for-treatment-of-canine-heartworm-disease
#7
Mark G Papich
BACKGROUND: Doxycycline has been considered the first drug of choice for treating Wolbachia, a member of the Rickettsiaceae, which has a symbiotic relationship with filarial worms, including heartworms. Wolbachia, is susceptible to tetracyclines, which have been used as adjunctive treatments for heartworm disease. Treatment with doxycycline reduces Wolbachia numbers in all stages of heartworms and improves outcomes and decreased microfilaremia in dogs treated for heartworm disease. The American Heartworm Society recommends treatment with doxycycline in dogs diagnosed with heartworm disease at a dose of 10 mg/kg twice daily for 28 days...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143237/john-henryism-gender-and-self-reported-health-among-roma-gypsies-in-serbia
#8
Jelena Čvorović, Sherman A James
We describe how self-reported health (SRH) varies with gender and John Henryism (a strong behavioral predisposition to engage in high-effort coping to overcome adversity) in a low income sample of Serbian Roma. Data were collected in 2016 in several Roma settlements around Belgrade, Serbia. The sample consisted of 90 men and 112 women. In addition to John Henryism (JH), measured by a Serbian version of the John Henryism Scale, demographic data and data on SRH and family relationships dynamics were collected...
November 15, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29143146/screening-transferable-microsatellite-markers-across-genus-phalaenopsis-orchidaceae
#9
Ya-Zhu Ko, Huei-Chuan Shih, Chi-Chu Tsai, Hsing-Hua Ho, Pei-Chun Liao, Yu-Chung Chiang
BACKGROUND: Molecular identification based on microsatellite loci is an important technology to improve the commercial breeding of the moth orchid. There are more than 30,000 cultivars have been enrolled at the Royal Horticultural Society (RHS). In this study, genomic microsatellite primer sets were developed from Phalaenopsis aphrodite subsp. formosana to further examine the transferability of across 21 Phalaenopsis species. METHODS AND RESULTS: Twenty-eight polymorphic microsatellite markers were obtained using the magnetic bead enrichment method, with high transferability of the 21 species of the genus Phalaenopsis, especially in the subgenus Phalaenopsis...
November 15, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29142116/indirectly-connected-simple-social-differences-can-explain-the-causes-and-apparent-consequences-of-complex-social-network-positions
#10
Josh A Firth, Ben C Sheldon, Lauren J N Brent
Animal societies are often structurally complex. How individuals are positioned within the wider social network (i.e. their indirect social connections) has been shown to be repeatable, heritable and related to key life-history variables. Yet, there remains a general lack of understanding surrounding how complex network positions arise, whether they indicate active multifaceted social decisions by individuals, and how natural selection could act on this variation. We use simulations to assess how variation in simple social association rules between individuals can determine their positions within emerging social networks...
November 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29141661/preventing-enduring-behavioural-problems-in-young-children-through-early-psychological-intervention-healthy-start-happy-start-study-protocol-for-a-randomized-controlled-trial
#11
Paul G Ramchandani, Christine O'Farrelly, Daphne Babalis, Marian J Bakermans-Kranenburg, Sarah Byford, Ellen S R Grimas, Jane E Iles, Marinus H van IJzendoorn, Julia McGinley, Charlotte M Phillips, Alan Stein, Jane Warwick, Hillary C Watt, Stephen Scott
BACKGROUND: Behavioural problems are common in early childhood, and can result in enduring costs to the individual and society, including an increased risk of mental and physical illness, criminality, educational failure and drug and alcohol misuse. Most previous research has examined the impact of interventions targeting older children when difficulties are more established and harder to change, and have rarely included fathers. We are conducting a trial of a psychological intervention delivered to families with very young children, engaging both parents where possible...
November 15, 2017: Trials
https://www.readbyqxmd.com/read/29140766/the-rise-of-alternative-bread-leavening-technologies-in-the-nineteenth-century
#12
Carolyn Ann Cobbold
This article reveals how nineteenth-century chemists and health reformers tried to eradicate the use of yeast in bread, claiming they had devised healthier and more sanitary ways to raise bread. It describes the alternative technological solutions to baking bread, investigating factors that influenced their development and adaptation in the marketplace. A lack of scientific and cultural consensus surrounding yeast, what it was and what it did, fermented during this period. The conflict over yeast helped create a heterogeneous industrialization of the baking industry, changing processes and ingredients and creating new forms of bakery products...
November 15, 2017: Annals of Science
https://www.readbyqxmd.com/read/29138694/impact-of-topically-administered-steroids-antibiotics-and-sodium-hyaluronate-on-bleb-related-infection-onset-the-japan-glaucoma-society-survey-of-bleb-related-infection-report-4
#13
Hideto Sagara, Tetsuya Yamamoto, Kimihiro Imaizumi, Tetsuju Sekiryu
Purpose: To investigate the impact of topically administered ophthalmic medications on the onset and severity of bleb-related infections. Methods: Data obtained from 104 eyes of 104 patients with bleb-related infections were analyzed. We assigned an infection stage to each eye (stage 1-4) and analyzed the onset severity. Results: Steroids and antibiotics were routinely administered to 13 (12.5%) and 42 (40.4%) eyes, respectively. The median stage of steroid-administered eyes was 3 versus 1 for eyes without steroid administration (P = 0...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29130486/rtp801-is-a-critical-factor-in-the-neurodegeneration-process-of-a53t-alpha-synuclein-in-a-mouse-model-of-parkinson-s-disease-under-chronic-restraint-stress
#14
Zhao Zhang, Shi-Feng Chu, Sha-Sha Wang, Yi-Na Jiang, Yan Gao, Peng-Fei Yang, Qi-Di Ai, Nai-Hong Chen
BACKGROUND AND PURPOSE: The incidence of Parkinson's disease exhibited a younger tendency in recent years with the constantly increased stressors of modern society, but this relationship remains obscured. We performed this study to investigate whether stress contributes to this tendency and identify the executor during this process. EXPERIMENTAL APPROACH: Ten-month-old α-synuclein A53T mice, a PD mice model, were treated with chronic restraint stress (CRS) to simulate a PD-sensitive person with constant stress stimulation...
November 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29128130/spanish-guidelines-on-the-evaluation-and-diagnosis-of-bronchiectasis-in-adults
#15
Miguel Ángel Martínez-García, Luis Máiz, Casilda Olveira, Rosa María Girón, David de la Rosa, Marina Blanco, Rafael Cantón, Montserrat Vendrell, Eva Polverino, Javier de Gracia, Concepción Prados
In 2008, the Spanish Society of Pulmonology (SEPAR) published the first guidelines in the world on the diagnosis and treatment of bronchiectasis. Almost 10 years later, considerable scientific advances have been made in both the treatment and the evaluation and diagnosis of this disease, and the original guidelines have been updated to include the latest scientific knowledge on bronchiectasis. These new recommendations have been drafted following a strict methodological process designed to ensure the quality of content, and are linked to a large amount of online information that includes a wealth of references...
November 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29126038/magnetic-resonance-imaging-findings-of-chronic-plantar-fasciitis-before-and-after-extracorporeal-shock-wave-therapy
#16
Masahiro Maki, Kazuya Ikoma, Masamitsu Kido, Yusuke Hara, Koshiro Sawada, Suzuyo Ohashi, Toshikazu Kubo
INTRODUCTION: The objective of this study is to examine the relationships between treatment outcome and changes in magnetic resonance (MR) imaging findings after extracorporeal shock wave therapy (ESWT) for chronic plantar fasciitis. METHODS: The subjects were 23 feet of 23 patients of refractory plantar fasciitis. The mean age was 53.7 years. The thickness of the plantar fascia (PF) and findings of a high-signal intensity area (HSIA) inside the PF, edema around the PF, and bone marrow edema (BME) of the calcaneus were investigated on MR images...
October 26, 2017: Foot
https://www.readbyqxmd.com/read/29125819/how-successful-are-turkish-orthopedists-in-complying-with-time-limit-in-scientific-presentations
#17
Nadir Yalçın, Enes Uluyardımcı, İbrahim Bozkurt
OBJECTIVES: This study aims to investigate the durations of scientific presentations and factors affecting the rates of exceeding the time limit in presentations at 26th Turkish National Congress of Orthopedics and Traumatology, which is one of Turkey's largest nationally organized orthopedics and traumatology meetings in terms of the numbers of speakers and participators. MATERIALS AND METHODS: Speech durations of Turkish orthopedists and the rates of these durations against the durations specified in the schedule were calculated...
December 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29125803/religiosity-and-the-concept-of-god-moderate-the-relationship-between-the-type-of-trauma-posttraumatic-cognitions-and-mental-health
#18
Justyna Kucharska
The aim of the study was to examine the role of religiosity as a moderator in the relationships between trauma, posttraumatic cognitions and mental health. A one-dimensional measure of religiosity and a multidimensional "concept of god" measure were used; sexual and non-sexual traumatic events were assessed and posttraumatic cognitions related to either sexual or non-sexual trauma were taken into account. A total of 337 females from Poland participated in the cross-sectional study. It was predicted that the relationships between sexual trauma and mental health would be stronger in religious individuals - this hypothesis was supported in the case of negative mental health (PTSD, z = -1...
November 10, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/29125691/virtual-environment-for-social-information-processing-assessment-of-children-with-and-without-autism-spectrum-disorders
#19
Nicole Russo-Ponsaran, Clark McKown, Jason Johnson, Jaclyn Russo, Jacob Crossman, Ilana Reife
Social information processing (SIP) skills are critical for developing and maintaining peer relationships. Building on existing assessment techniques, Virtual Environment for SIP (VESIP(TM) ), a simulation-based assessment that immerses children in social decision-making scenarios, was developed. This study presents preliminary evidence of VESIP's usefulness for measuring SIP skills in children with and without autism spectrum disorders (ASD). Twenty-one children with ASD and 29 control children participated...
November 10, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29123356/translational-research-in-oncology-implications-for-palliative-care
#20
Arunangshu Ghoshal
The label "translational research" (TR) has become ever more popular in the biomedical domain in recent years. It is usually presented as an attempt to bridge a supposed gap between knowledge produced at the laboratory bench and its use at the clinical bedside. This is claimed to help society harvest the benefits of its investments in scientific research. The past decade has witnessed a remarkable acceleration in the pace of translational cancer medicine - genome sequencing of various human cancers has been broadly deployed in drug discovery programs, diagnostic tests have been developed to predict molecularly targeted anticancer agents, advent of cancer immunotherapies, an enhanced appreciation of the complex interactions that exist between tumor cells and their microenvironment have revolutionized the management of cancers...
October 2017: Indian Journal of Palliative Care
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