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https://www.readbyqxmd.com/read/29786880/metagenomic-study-of-bacterial-microbiota-in-persistent-endodontic-infections-using-next-generation-sequencing
#1
G Sánchez-Sanhueza, H Bello-Toledo, G González-Rocha, A T Gonçalves, V Valenzuela, C Gallardo-Escárate
AIM: To determine the bacterial microbiota in root canals associated with persistent apical periodontitis and their relationship with the clinical characteristics of patients using next-generation sequencing (NGS). METHODOLOGY: Bacterial samples from root canals associated with teeth having persistent apical periodontitis were taken from 24 patients undergoing root canal retreatment. Bacterial DNA was extracted, and V3-V4 variable regions of the 16S rRNA gene were amplified...
May 22, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29786117/the-relevance-of-the-hippocratic-oath-to-the-ethical-and-moral-values-of-contemporary-medicine-part-ii-interpretation-of-the-hippocratic-oath-today-s-perspective
#2
REVIEW
Helen Askitopoulou, Antonis N Vgontzas
This is the second part of a paper on the relevance and significance of the Hippocratic Oath to modern medical ethical and moral values with the aim at answering questions on controversial issues related to the Oath. Part I argued that the general attributes and ethical values of the Oath are relevant to the modern world. Part II attempts to elucidate the interpretation of the specific injunctions of the Oath from today's perspective in relation to ethical values concerning the duties of physicians to patients and society...
May 21, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29785797/relationship-between-handgrip-strength-and-pulmonary-function-in-apparently-healthy-older-women
#3
Da-Hye Son, Ji-Won Yoo, Mi-Ra Cho, Yong-Jae Lee
OBJECTIVES: To investigate the relationship between handgrip strength and pulmonary function. DESIGN: Cross-sectional study of a representative sample of older Korean women. SETTING: The Korean National Health and Nutrition Examination Survey. PARTICIPANTS: Community-dwelling women aged 65 and older without chronic diseases or pulmonary disease (N=605). MEASUREMENTS: Handgrip strength was measured using a digital hand dynamometer, and pulmonary function was tested according to guidelines of the American Thoracic Society/European Respiratory Society using a spirometry system...
May 21, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29782573/what-clicks-actually-mean-exploring-digital-news-user-practices
#4
Tim Groot Kormelink, Irene Costera Meijer
This article problematizes the relationship between clicks and audience interests. Clicking patterns are often seen as evidence that news users are mostly interested in junk news, leading to concerns about the state of journalism and the implications for society. Asking and observing how 56 users actually browse news and what clicking and not clicking mean to them, we identified 30 distinct considerations for (not) clicking and classified them into three categories: cognitive, affective and pragmatic. The results suggest, first, that interest is too crude a term to account for the variety of people's considerations for (not) clicking...
May 2018: Journalism: theory, practice, and criticism
https://www.readbyqxmd.com/read/29782406/population-pharmacokinetics-and-pharmacodynamics-of-dexmedetomidine-in-children-undergoing-ambulatory-surgery
#5
María-Gabriela Pérez-Guillé, Alejandra Toledo-López, Liliana Rivera-Espinosa, Radames Alemon-Medina, Chiharu Murata, Ismael Lares-Asseff, Juan Luis Chávez-Pacheco, Josefina Gómez-Garduño, Ana-Lilia Zamora Gutiérrez, Claudia Orozco-Galicia, Karina Ramírez-Morales, Gustavo Lugo-Goytia
BACKGROUND: Dexmedetomidine (DEX) is an α-2 adrenergic agonist with sedative and analgesic properties. Although not approved for pediatric use by the Food and Drug Administration, DEX is increasingly used in pediatric anesthesia and critical care. However, very limited information is available regarding the pharmacokinetics of DEX in children. The aim of this study was to investigate DEX pharmacokinetics and pharmacodynamics (PK-PD) in Mexican children 2-18 years of age who were undergoing outpatient surgical procedures...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29782319/the-relationship-between-obstructive-sleep-apnea-and-alzheimer-s-disease
#6
Andreia Andrade, Omonigho M Bubu, Andrew W Varga, Ricardo S Osorio
 Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29780694/towards-a-new-way-of-interacting-pondering-the-role-of-an-interpersonal-ethos
#7
François Levrau
Both multiculturalism and interculturalism strive for the creation of a well-ordered society in which the integration of all citizens is realized. This shared ambition, however, can only be realized if the quality of the social relationships is deeply considered. By proposing the concept of 'interpersonal ethos' it is explained why and how the way ordinary people socially interact across ethnocultural and religious diversity shapes the stability, success and fairness of a super diverse society.
2018: Comparative Migration Studies
https://www.readbyqxmd.com/read/29780203/only-when-the-societal-impact-potential-is-high-a-panel-study-of-the-relationship-between-public-service-motivation-and-perceived-performance
#8
Nina van Loon, Anne Mette Kjeldsen, Lotte Bøgh Andersen, Wouter Vandenabeele, Peter Leisink
Many studies find positive associations between public service motivation (PSM) and performance, but much of this literature is based on cross-sectional data prone to endogeneity and common method bias. Moreover, we know little about potential moderators. In this study, we test the moderating role of societal impact potential (SIP)-the degree to which the job is perceived to provide opportunities to contribute to society. We use cross-sectional data from 13,967 employees in 2010 and 2012 aggregated to construct longitudinal data for 42 organizations...
June 2018: Review of Public Personnel Administration
https://www.readbyqxmd.com/read/29778726/incidence-determinants-and-outcomes-of-left-and-right-radial-access-use-in-patients-undergoing-percutaneous-coronary-intervention-in-the-united-kingdom-a-national-perspective-using-the-bcis-dataset
#9
Muhammad Rashid, Claire Lawson, Jessica Potts, Evangelos Kontopantelis, Chun Shing Kwok, Olivier F Bertrand, Ahmad Shoaib, Peter Ludman, Tim Kinnaird, Mark de Belder, James Nolan, Mamas Mamas
OBJECTIVES: The authors sought to determine the relationships between left radial access (LRA) or right radial access (RRA) and clinical outcomes using the British Cardiovascular Intervention Society (BCIS) database. BACKGROUND: LRA has been shown to offer procedural advantages over RRA in percutaneous coronary intervention (PCI) although few data exist from a national perspective around its use and association with clinical outcomes. METHODS: The authors investigated the relationship between use of LRA or RRA and clinical outcomes of in-hospital or 30-day mortality, major adverse cardiovascular events, in-hospital stroke, and major bleeding complications in patients undergoing PCI between 2007 and 2014...
May 11, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29777478/the-relationship-with-restless-legs-syndrome-fibromyalgia-and-depressive-symptoms-in-migraine-patients
#10
Zehra Akdag Uzun, Semiha Kurt, Hatice Karaer Unaldi
OBJECTIVE: In this study, we aimed to investigate restless legs syndrome, depression, frequency of fibromyalgia and possible causes of its frequencies, and the relationships among these synergies and migraine's prodrome, aura, pain, and postdrome symptoms in patients with migraine. SUBJECTS AND METHODS: The study group included 200 patients previously or recently diagnosed with definite migraine and according to International Headache Society criteria and 200 healthy volunteers...
May 18, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29776625/childhood-socioeconomic-status-and-risk-in-early-family-environments-predictors-of-global-sleep-quality-in-college-students
#11
Cory J Counts, Fiona C Grubin, Neha A John-Henderson
OBJECTIVE: Low socioeconomic status (SES) in childhood associates with poor sleep quality in adulthood. Separately, childhood family environments shape health into adulthood. Here, we investigated whether these early life factors independently or interactively inform global sleep quality in college students. DESIGN: Cross-sectional. PARTICIPANTS: College students at a state university (N = 391). MEASUREMENTS: As a measure of childhood SES, we asked participants to consider their families' socioeconomic standing relative to the rest of the society during their childhood...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29775902/type-1-diabetes-through-the-lens-of-human-genome-and-metagenome-interplay
#12
REVIEW
Sepideh Zununi Vahed, Hakimeh Moghaddas Sani, Yalda Rahbar Saadat, Abolfazl Barzegari, Yadollah Omidi
Diabetes is a genetic- and epigenetic-related disease from which a large population worldwide suffers. Some genetic factors along with various mutations related to the immune system for disease mechanism(s) have contrastively been determined. However, sometimes mechanisms have not been fully managed for the clarification of the initiation and/or progression of diseases to help patients. In the recent years, due to familiarity with the role of gut microbiota in the health, it has been found that the changes of the microbial balance in the industrialized societies can cause a battery of modern diseases, for which we have no specific definition of how they emerge...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775832/stressed-out-an-investigation-of-whether-allostatic-load-mediates-associations-between-neighbourhood-deprivation-and-health
#13
Lucy Prior, David Manley, Kelvyn Jones
Deprived neighbourhoods have long been associated with poorer health outcomes. However, many quantitative studies have not evidenced the mechanisms through which place 'gets under the skin' to influence health. The increasing prevalence of biosocial data provides new opportunities to explore these mechanisms and incorporate them into models of contextual effects. The stress pathway is a key biosocial mechanism; however, few studies have explicitly tested it in neighbourhood associations. This paper addresses this gap by investigating whether allostatic load, a biological response to chronic stress, mediates relationships of neighbourhood deprivation to physical and mental health...
May 15, 2018: Health & Place
https://www.readbyqxmd.com/read/29775475/perceptions-of-community-safety-and-social-activity-participation-among-youth-in-south-africa
#14
Nicole De Wet, Oluwaseyi Somefun, Ndivhuwo Rambau
BACKGROUND: Crime and violence causes massive disruptions to the health, survival and development of populations. In South Africa, incredibly high rates of crime and violence are noted. The country also has a very large youth population whose health, survival and development are key to economic growth. Among other efforts to encourage healthy youth development and the promotion of social activities such as sports, youth groups, choirs and so forth. This study examines the relationship between perceived community safety and the uptake of social activities among youth in South Africa...
2018: PloS One
https://www.readbyqxmd.com/read/29774266/reforming-birth-registration-law-in-england-and-wales
#15
Julie McCandless
The Law Commission of England and Wales is considering what its 13th Programme of Law Reform should address. During the consultation process, a project on birth registration law has been mooted. This is a very welcome proposal given that civil birth registration in England and Wales is a compulsory procedure that not only finds its roots in the early Victorian era, but also remains very similar, at least in terms of form and the information that is recorded. I first use two recent legal challenges to illustrate why the current system is coming under increasing pressure...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774263/a-cross-cultural-analysis-of-posthumous-reproduction-the-significance-of-the-gender-and-margins-of-life-perspectives
#16
Yael Hashiloni-Dolev, Silke Schicktanz
The scholarly discussion of posthumous reproduction (PHR) focuses on informed consent and the welfare of the future child, for the most part overlooking cultural differences between societies. Based on a cross-cultural comparison of legal and regulatory documents, analysis of pivotal cases and study of scholarly and media discussions in Israel and Germany, this paper analyses the relevant ethical and policy issues, and questions how cultural differences shape the practice of PHR. The findings challenge the common classifications of PHR by highlighting the gender perspective and adding brain-dead pregnant women to the debate...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29769297/mechanistic-models-versus-machine-learning-a-fight-worth-fighting-for-the-biological-community
#17
REVIEW
Ruth E Baker, Jose-Maria Peña, Jayaratnam Jayamohan, Antoine Jérusalem
Ninety per cent of the world's data have been generated in the last 5 years ( Machine learning: the power and promise of computers that learn by example Report no. DES4702. Issued April 2017. Royal Society). A small fraction of these data is collected with the aim of validating specific hypotheses. These studies are led by the development of mechanistic models focused on the causality of input-output relationships. However, the vast majority is aimed at supporting statistical or correlation studies that bypass the need for causality and focus exclusively on prediction...
May 2018: Biology Letters
https://www.readbyqxmd.com/read/29769252/frequency-of-non-motor-symptoms-in-parkinson-s-disease-presenting-to-tertiary-care-centre-in-pakistan-an-observational-cross-sectional-study
#18
Shahid Mukhtar, Rashid Imran, Mohsin Zaheer, Huma Tariq
OBJECTIVE: To determine the frequency of non-motor symptoms (NMS) in patients of Parkinson's disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients. STUDY DESIGN: Observational, cross-sectional study. SETTING: Tertiary care centre. PARTICIPANTS: Out of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29766979/playing-it-cool-characterizing-social-play-bout-termination-and-candidate-play-signals-of-juvenile-and-infant-tibetan-macaques-macaca-thibetana
#19
Kaitlin R Wright, Jessica A Mayhew, Lori K Sheeran, Jake A Funkhouser, Ronald S Wagner, Li-Xing Sun, Jin-Hua Li
Play behaviors and signals during playful interactions with juvenile conspecifics are important for both the social and cognitive development of young animals. The social organization of a species can also influence juvenile social play. We examined the relationships among play behaviors, candidate play signals, and play bout termination in Tibetan macaques (Macaca thibetana) during juvenile and infant social play to characterize the species play style. As Tibetan macaques are despotic and live in groups with strict linear dominance hierarchies and infrequent reconciliation, we predicted that play would be at risk of misinterpretation by both the individuals engaged in the play bout and by those watching, possibly leading to injury of the players...
July 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/29765218/the-effects-of-maras-powder-use-on-patients-with-migraine
#20
Yılmaz İnanç, Fatma Özlem Orhan, Yusuf İnanç
Background: It is accepted that smoking often triggers migraine. However, studies evaluating the relationship between the use of smokeless tobacco and migraine are limited, and there is no clear consensus on the subject. In this study, it was aimed to evaluate the relationship between migraine and Maras powder, which is the most common smokeless tobacco in Turkey. Subjects and methods: The study included a total of 600 subjects, consisting of 300 patients (aged >18 years) diagnosed with a migraine according to the International Headache Society (IHS-ICHD-3 Beta) criteria after presenting at Sütçü Imam University Medical Faculty Neurology Policlinic with the complaint of headache between July 2016 and December 2016 and a control group of 300 individuals with similar features of age, gender, and educational level...
2018: Neuropsychiatric Disease and Treatment
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