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https://www.readbyqxmd.com/read/29350802/cellular-reprogramming-a-new-way-to-understand-aging-mechanisms
#1
REVIEW
Burcu Yener Ilce, Umut Cagin, Acelya Yilmazer
Increased life expectancy, due to the rise in life quality and the decline in mortality rates, is leading to a society in which the population aged 60 and over is growing more rapidly than the entire population. Although various models and model organisms have been employed to investigate the mechanism of aging, induced pluripotent stem cells (iPSCs) are useful candidates to study human aging and age-related human diseases. This work discusses how iPSCs can be used as an alternative to the model organisms such as yeast, Caenorhabditis elegans, Drosophila melanogaster, or the mouse...
January 19, 2018: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29350592/geographic-proximity-to-specialized-pediatric-neurosurgical-care-in-the-contiguous-united-states
#2
Abdul-Kareem Ahmed, Ann-Christine Duhaime, Timothy R Smith
OBJECTIVE Absent from an analysis of supply is consideration of the geographic distribution of pediatric neurosurgeons. Several patient socioeconomic metrics are known to be associated with outcome in pediatric neurosurgical diseases, such as hydrocephalus. The purpose of this study was to determine current geographic proximity to pediatric neurosurgical care using professional society databases. This study also sought to establish how socioeconomic factors are related to distance to care, using federal government-collected data...
January 19, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29349278/machine-learning-approaches-to-the-social-determinants-of-health-in-the-health-and-retirement-study
#3
Benjamin Seligman, Shripad Tuljapurkar, David Rehkopf
Background: Social and economic factors are important predictors of health and of recognized importance for health systems. However, machine learning, used elsewhere in the biomedical literature, has not been extensively applied to study relationships between society and health. We investigate how machine learning may add to our understanding of social determinants of health using data from the Health and Retirement Study. Methods: A linear regression of age and gender, and a parsimonious theory-based regression additionally incorporating income, wealth, and education, were used to predict systolic blood pressure, body mass index, waist circumference, and telomere length...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29341497/defining-behavioral-components-of-social-functioning-in-adults-with-autism-spectrum-disorder-as-targets-for-treatment
#4
Ashley A Pallathra, Monica E Calkins, Julia Parish-Morris, Brenna B Maddox, Leat S Perez, Judith Miller, Ruben C Gur, David S Mandell, Robert T Schultz, Edward S Brodkin
There is increasing recognition that adults with autism spectrum disorder (ASD) would benefit from treatment to improve social functioning, a key factor in adults' overall quality of life. However, the various behavioral components of social functioning (i.e., categories of behaviors underlying social functioning), including social motivation, social anxiety, social cognition, and social skills, have not all been assessed together in any sample of adults with ASD, making it difficult to know the relative levels of impairment in these various categories, the relationships among these categories, or promising targets for treatments...
January 17, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29339029/degree-of-tinnitus-improvement-with-stapes-surgery-a-review
#5
Aliciane Mota G Cavalcante, Isabella Monteiro de Castro Silva, Bianca Jessica Neves, Carlos Augusto Oliveira, Fayez Bahmad
INTRODUCTION: Otospongiosis is temporal bone osteodystrophy, characterized by disordered bone resorption and neoformation in genetically predisposed individuals. Clinically, otospongiosis is characterized by progressive conductive and/or mixed hearing loss and by tinnitus. OBJECTIVE: A review of the last two decades of publications that report the degree of tinnitus improvement with stapes surgery. METHODS: 125 articles published in the last 20 years mentioning the relationship between otosclerosis and tinnitus...
January 5, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29338086/cardiometabolic-risk-factors-and-survival-after-breast-cancer-in-the-women-s-health-initiative
#6
Michael S Simon, Jennifer L Beebe-Dimmer, Theresa A Hastert, JoAnn E Manson, Elizabeth M Cespedes Feliciano, Marian L Neuhouser, Gloria Y F Ho, Jo L Freudenheim, Howard Strickler, Julie Ruterbusch, Ana Barac, Rowan Chlebowski, Bette Caan
BACKGROUND: Few studies have examined the relationship between cardiometabolic risk factors linked to metabolic syndrome and mortality among women with breast cancer. METHODS: We used the Women's Health Initiative to evaluate the relationship between cardiometabolic risk factors, including waist circumference (WC), blood pressure, cholesterol level, and presence of type 2 diabetes, and their relation with death from breast cancer, cardiovascular disease (CVD), and other causes among 8641 women with local or regional stage invasive breast cancer...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29335657/changing-gender-norms-and-marriage-dynamics-in-the-united-states
#7
Léa Pessin
Using a regional measure of gender norms from the General Social Surveys together with marital histories from the Panel Study of Income Dynamics, this study explored how gender norms were associated with women's marriage dynamics between 1968 and 2012. Results suggested that a higher prevalence of egalitarian gender norms predicted a decline in marriage formation. This decline was, however, only true for women without a college degree. For college-educated women, the association between gender norms and marriage formation became positive when gender egalitarianism prevailed...
February 2018: Journal of Marriage and the Family
https://www.readbyqxmd.com/read/29334953/care-relationships-at-stake-home-healthcare-professionals-experiences-with-digital-medicine-dispensers-a-qualitative-study
#8
Sigrid Nakrem, Marit Solbjør, Ida Nilstad Pettersen, Hanne Hestvik Kleiven
BACKGROUND: Although digital technologies can mitigate the burdens of home healthcare services caused by an ageing population that lives at home longer with complex health problems, research on the impacts and consequences of digitalised remote communication between patients and caregivers is lacking. The present study explores how home healthcare professionals had experienced the introduction of digital medicine dispensers and their influence on patient-caregiver relationships. METHODS: The multi-case study comprised semi-structured interviews with 21 healthcare professionals whose home healthcare service involved using the digital medicine dispensers...
January 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29333825/6-minutes
#9
Pablo R Justich Zabala
At present, there is a trend towards reducing the duration of office visits. In some regions of Spain, it has been set at 6 minutes per patient. This impacts on several levels: literally, many times it is impossible to complete the medical act; at an emotional level, because there is little possibility to establish an adequate doctor-patient relationship; and symbolically, for considering that the main aspects of humane health care are expendable. This takes place in a society that tends to see health care as a merchandise subject to market rules that gives priority to the immediate over the important...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333461/extracorporeal-shock-wave-therapy-for-coronary-artery-disease-relationship-of-symptom-amelioration-and-ischemia-improvement
#10
Youko Takakuwa, Masayoshi Sarai, Hideki Kawai, Akira Yamada, Kenji Shiino, Kayoko Takada, Yasuomi Nagahara, Meiko Miyagi, Sadako Motoyama, Hiroshi Toyama, Yukio Ozaki
Objectives: The current management of coronary artery disease (CAD) relies on three major therapeutic options, namely medication, percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). However, severe CAD that is not indicated for PCI or CABG still bears a poor prognosis due to the lack of effective treatments. In 2006, extracorporeal cardiac shock wave (SW) therapy reported on human for the first time. This treatment resulted in better myocardial perfusion as evaluated by dipyridamole stress thallium scintigraphy, angina symptoms, and exercise tolerance...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29331952/inter-relationship-between-ocular-perfusion-pressure-blood-pressure-intraocular-pressure-profiles-and-primary-open-angle-glaucoma-the-singapore-epidemiology-of-eye-diseases-study
#11
Yih-Chung Tham, Sing-Hui Lim, Preeti Gupta, Tin Aung, Tien Y Wong, Ching-Yu Cheng
OBJECTIVE: To elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria...
January 13, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29331823/pre-pregnancy-maternal-depressive-symptoms-and-low-birth-weight-and-preterm-birth-outcomes-assessment-of-adolescent-background-characteristics-and-birth-outcomes-in-adulthood
#12
Stephen Nkansah-Amankra
PURPOSE: In the United States and other countries of the world , high prevalence of pre-pregnancy depressive symptoms and depression during pregnancy is an important public health concern, as they are associated with low birth weight (LBW) and preterm birth (PTB) outcomes in adulthood. However, the relationships among pre-pregnancy depressive symptoms, low birth weight, preterm birth outcomes and household characteristics have not been well established. METHODS: The study used data from 7120 adolescent female participants in the National Longitudinal Study of Adolescent to Adult Health data from Waves I (1994-1995 in-school interview), II (1996 as in-home), III (2001-2002 as in-home interview), IV (2008 as in-home interview) and Wave V is currently underway...
December 13, 2017: Midwifery
https://www.readbyqxmd.com/read/29331093/sensitivity-to-audio-visual-synchrony-and-its-relation-to-language-abilities-in-children-with-and-without-asd
#13
Giulia Righi, Elena J Tenenbaum, Carolyn McCormick, Megan Blossom, Dima Amso, Stephen J Sheinkopf
Autism Spectrum Disorder (ASD) is often accompanied by deficits in speech and language processing. Speech processing relies heavily on the integration of auditory and visual information, and it has been suggested that the ability to detect correspondence between auditory and visual signals helps to lay the foundation for successful language development. The goal of the present study was to examine whether young children with ASD show reduced sensitivity to temporal asynchronies in a speech processing task when compared to typically developing controls, and to examine how this sensitivity might relate to language proficiency...
January 13, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29330577/asymptomatic-population-reference-values-for-three-knee-patient-reported-outcomes-measures-evaluation-of-an-electronic-data-collection-system-and-implications-for-future-international-multi-centre-cohort-studies
#14
James M McLean, Oscar Brumby-Rendell, Ryan Lisle, Jacob Brazier, Kieran Dunn, Tiffany Gill, Catherine L Hill, Daniel Mandziak, Jordan Leith
OBJECTIVES: The aim was to assess whether the Knee Society Score, Oxford Knee Score (OKS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) were comparable in asymptomatic, healthy, individuals of different age, gender and ethnicity, across two remote continents. The purpose of this study was to establish normal population values for these scores using an electronic data collection system. HYPOTHESIS: There is no difference in clinical knee scores in an asymptomatic population when comparing age, gender and ethnicity, across two remote continents...
January 12, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29327043/association-of-oral-microbiome-with-risk-for-incident-head-and-neck-squamous-cell-cancer
#15
Richard B Hayes, Jiyoung Ahn, Xiaozhou Fan, Brandilyn A Peters, Yingfei Ma, Liying Yang, Ilir Agalliu, Robert D Burk, Ian Ganly, Mark P Purdue, Neal D Freedman, Susan M Gapstur, Zhiheng Pei
Importance: Case-control studies show a possible relationship between oral bacteria and head and neck squamous cell cancer (HNSCC). Prospective studies are needed to examine the temporal relationship between oral microbiome and subsequent risk of HNSCC. Objective: To prospectively examine associations between the oral microbiome and incident HNSCC. Design, Setting, and Participants: This nested case-control study was carried out in 2 prospective cohort studies: the American Cancer Society Cancer Prevention Study II Nutrition Cohort (CPS-II) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)...
January 11, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29325565/impact-of-social-relationships-on-alzheimer-s-memory-impairment-mechanistic-studies
#16
REVIEW
Ya-Hsin Hsiao, Chih-Hua Chang, Po-Wu Gean
Alzheimer's disease (AD) is characterized by progressive memory and neuronal loss culminating in cognitive impairment that not only affects a person's living ability but also becomes a society's as well as a family's economic burden. AD is the most common form of dementia in older persons. It is expected that the number of people with AD dementia will increase dramatically in the next 30 years, projecting to 75 million in 2030 and 131.5 million in 2050 worldwide. So far, no sufficient evidence is available to support that any medicine is able to prevent or reverse the progression of the disease...
January 11, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29324764/competing-for-the-same-value-segments-insight-into-the-volatile-dutch-political-landscape
#17
Hester van Herk, Pieter C Schoonees, Patrick J F Groenen, Joost van Rosmalen
Values are central to public debates today. Human values convey broad goals that serve as guiding principles in a person's life and value priorities differ across people in society. Groups in society holding opposing values (e.g., universalism versus security) will make different choices when voting in an election. Whereas over time, values are relatively stable, the number and type of political parties as well as the political values they communicate and disseminate have been changing. Groups of people holding the same human values may therefore vote for another (new) party in a later election...
2018: PloS One
https://www.readbyqxmd.com/read/29324526/do-professional-society-advocacy-campaigns-have-an-impact-on-pediatric-orthopaedic-injuries
#18
Alexa J Karkenny, Denver A Burton, Kathleen J Maguire, Regina Hanstein, Norman Y Otsuka
PURPOSE: The American Academy of Orthopaedic Surgeons (AAOS) and the American Academy of Pediatrics (AAP) both advocate for childhood injury prevention by publishing recommendations to orthopaedic surgeons, pediatricians, and the public. Popular topics of advocacy campaigns have included trampolines, all-terrain vehicles (ATVs), and lawnmowers. The purpose of this study was to investigate the temporal relationship between AAOS/AAP advocacy and pediatric orthopaedic injury rates, using these topics as examples...
January 10, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29323208/composition-of-salivary-microbiota-in-elderly-subjects
#19
Taiji Ogawa, Yujiro Hirose, Mariko Honda-Ogawa, Minami Sugimoto, Satoshi Sasaki, Masahito Kibi, Shigetada Kawabata, Kazunori Ikebe, Yoshinobu Maeda
Frailty is gaining attention worldwide with the aging of society. Despite the potential lethality and multiple signs and symptoms in affected individuals, preclinical detection of early manifestations leading to frailty syndrome have not been established. We speculated that the composition of the oral microbiota is associated with general frailty, as well as a relationship between gut microbiota and general health condition. In the present study, we investigated the salivary microbiota composition in samples from healthy and frail elderly individuals using 16S rRNA sequencing analysis for characterization...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323040/d-dimer-may-predict-poor-outcomes-in-patients-with-aneurysmal-subarachnoid-hemorrhage-a-retrospective-study
#20
Jun-Hui Liu, Xiang-Kui Li, Zhi-Biao Chen, Qiang Cai, Long Wang, Ying-Hu Ye, Qian-Xue Chen
Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysmal subarachnoid hemorrhage who were treated in Renmin Hospital of Wuhan University of China between 1 May 2014 and 30 March 2016. There were 57 males and 89 females included and average age of included patients was 57...
December 2017: Neural Regeneration Research
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