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Rhumatoid arthritis

Marie Febvre-James, Arnaud Bruyère, Marc Le Vée, Olivier Fardel
The inflammatory cytokine interleukin (IL)-6, which basically activates the Janus kinase (JAK)/ signal transducer and activator of transcription (STAT) signaling pathway, is well known to repress expression of hepatic cytochromes P-450 (P450s) and transporters. Therapeutic proteins, like monoclonal antibodies targeting IL-6 or its receptor, have consequently been demonstrated to restore full hepatic detoxification capacity, which results in inflammatory disease-related drug-drug interactions (idDDIs). In the present study, we investigated whether ruxolitinib, a small drug acting as a JAK1/2 inhibitor and currently used in the treatment of myeloproliferative neoplasms, may also counteract the repressing effects of IL-6 toward hepatic detoxifying systems...
February 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Helene Che, Bernard Combe, Jacques Morel, Alain Cantagrel, Laure Gossec, Cedric Lukas
OBJECTIVES: Rheumatoid arthritis (RA) activity can be assessed by several outcome measures. The importance of patient-reported outcomes (PROs) has recently been advocated. Our objective was to determine whether patient self-assessment can reflect RA disease activity. METHODS: Data from patients included in the early arthritis ESPOIR cohort and fulfilling 2010 ACR/EULAR criteria for RA at month 12 were used. Data for several PROs (visual analogue scale for fatigue, pain, patient assessment of disease activity; Health Assessment Questionnaire [HAQ]; Medical Outcomes Study Short Form 36 [SF36]; Echelle de Mesure de l'Impact de la polyarthrite Rhumatoïde-court [EMIR-court] and Routine Assessment of Patient Index Data 3 [RAPID3]) were collected and their association with disease activity measured by Disease Activity Score in 28 joints-3 variables (DAS28-3v) was assessed...
July 2016: Clinical and Experimental Rheumatology
N Benmostefa, A Bouzia, F Akaba, S Kouach, N H Guettaf, R Malek
OBJECTIFS: La mortalité dans la polyarthrite rhumatoïde (PR) est élevée en raison de la survenue d'événements cardiovasculaires. Le risque cardiovasculaire augmenté dans la PR est essentiellement lié à l'état inflammatoire chronique ainsi que d'autres facteurs comme les traitements, notamment la corticothérapie qui jouerait un rôle capital. Nous rapportant le cas d'une gangrène survenue sur athérosclérose ayant compliqué une polyarthrite rhumatoïde. MéTHODES: Patiente de 53 ans, connue et traitée pour une polyarthrite rhumatoïde depuis 20 ans, était admise pour exploration d'une ostéoporose avec une gangrène sèche du gros orteil droit...
December 2015: Annales de Cardiologie et D'angéiologie
G Titeca, L Goudetsidis, A Laka, D Jardinet, F Poot
BACKGROUND: Rhumatoid arthritis (RA) is a chronic inflammatory joint disease. It appears to be caused by a combination of genetic and environmental factors. It may be accompanied by well-known extra-articular damage (e.g. lung, kidney, heart), while cutaneous involvement such as rheumatoid neutrophilic dermatitis (RND) is much less frequent. PATIENTS AND METHODS: A 64-year-old woman was referred by rheumatologists after she developed a cutaneous eruption on the forearms, elbows and scalp in a setting of progressive RA...
October 2014: Annales de Dermatologie et de Vénéréologie
H Ben Fredj, H Ben Saad, N Mhaouech, I Bouajina, Z Tabka, S Rouatbi
BACKGROUND: The rheumatoid polyarthritis (PR) is a frequent pathology in Tunisia. The most frequent extra articular expression of this disease is in the respiratory tract. AIM: To determine the lung functional profile of PR of the Tunisian population by establishing possible relations between ventilatory variables and clinico-biological parameters of PR. METHODS: It is a cross sectional study which concerned 87 patients (77 women) having a confirmed PR...
April 2013: La Tunisie Médicale
Bruno Fautrel, Francis Guillemin, Olivier Meyer, Michel de Bandt, Jean-Marie Berthelot, René-Marc Flipo, Frédéric Lioté, Jean-Francis Maillefert, Daniel Wendling, Alain Saraux, Bernard Combe, Xavier Le Loët
OBJECTIVE: To survey rheumatologists' preferences for the choice of a second-line disease-modifying antirheumatic drug (DMARD) after inadequate response with methotrexate (MTX) therapy in rheumatoid arthritis (RA). METHODS: Thirty-six rheumatologists stated their preferences for RA treatment after inadequate response with MTX therapy (optimal dose at least 6 months). From the initial scenario, we derived 54 vignettes varying by rheumatoid factor or anti-cyclic citrullinated peptide antibody presence, swollen joint count, Disease Activity Score in 28 joints, and structural damage...
April 15, 2009: Arthritis and Rheumatism
S Ndongo, M M Ka, A Pouye, E F Ka, S Diallo, T M Diop
INTRODUCTION: Methotrexate used as antimetabolite since 40 years in cancerology, is curretly pointed out at weak dose in the treatment of rheumatoid arthitis. However, the intervening of undesirable effects is currently the principal factor limiting its use. The main of our study was evaluate the nature and the frequency of undesirable effects during treatement of rhumatoid arthritis by methotrexate in a prospective study in the department of internal medecine of A.L.D hospital. MATERIAL AND METHODS: Fifty patients were included in the study, they were 43 female and 7 male (sex ratio of 0...
2007: Dakar Médical
B Bonnemain
Iron oxide particles can be divided into two categories: small superparamagnetic iron oxide (SPIO) and ultrasmall superparamagnetic iron oxide (USPIO). Both describe nanoparticles most often formulated with dextran or dextran derivatives. For magnetic resonance imaging, these agents are of major importance because of their superparamagnetic effect, that is the magnetic field generated locally by their presence. Clinical applications have been well differentiated: 1) SPIO (larger than 50nm) are mainly used via intravenous infusion to detect and characterize small focal lesions in the liver...
November 2008: Annales Pharmaceutiques Françaises
No abstract text is available yet for this article.
September 1949: American Practitioner and Digest of Treatment
Samir Kochbati, Fatma Boussema, Mohamed Ben Miled, Sarra Shili, Mohamed Chérif, Golsom Ben Amor, C Jemni, Hella Mzabi, Ouahida Chérif, Mohamed Habib Daghfous, Lilia Rokbani
To evaluate the prevalence of bronchiectasis in rhumatoid arthritis (RA) we have study thirty patients (24 women and 6 men), with a mean age of 45,2 years. All patients have a RA with a follow up of 5,84 years, positive rhumatoid factor were found in 22 cases. All patients have had high resolution computed pulmonary tomography, study of clinical, radiological and spirometry parameters. Bronchiectasis was found in 5 cases (16,6%) and is the most frequent abnormality found. These bronchiectasis are associated to an interstitial syndrome (2 cases) and pleural node (1 case)...
October 2003: La Tunisie Médicale
S Ndongo, A Pouye, M M Ka, A Leye, A D Ndiaye, T M Diop
INTRODUCTION: Polymyositis is a chronic inflammatory disease possibly responsable of various systemic manifestations. PATIENTS AND METHODS: Reported is a retrospective done on polymyositis i n internal medecine department in patients from march 1997 to april 2002. RESULTS: Eleven cases were collected from a total of 6739 admissions giving a prevalence of 0.16%. Sex ratio was 1.2(F/H) with a mean age of 33 years. The most frequent clinical presentation was the muscle signs...
2005: Dakar Médical
H Ntsiba, M Ngandeu-Singwé, C Makita-Bagamboula, F Yala
OBJECTIVE: The authors report epidemiologic, clinical, para clinical, and evolutive aspects of arthritis related to HIV in an AIDS endemic country. MATERIAL AND METHODS: A retrospective study was made in the rheumatology department of the Brazzaville University Teaching Hospital during 15 years and 6 months, on 3.042 in-patients among whom 306 (10%) were positive for HIV, 220 (7.2%) presented with a rheumatologic manifestation, and 158 (71.8%) with HIV related arthritis...
November 2007: Médecine et Maladies Infectieuses
Sahli Hela, Hamdi Wafa, Hamza Sami, Cheour Elhem, Meddeb Nihel, Sellami Slaheddine
We present the case a 53-year-old patient followed-up since 1999, for erosive AR treated with methotrexate and glucocorticoids. In April 2000, he had an arthritis of the right knee. The identification of an enterobacter in blood culture, and synovial biopsy results permitted the diagnosis of septic arthritis. After 23 days of antibioterapy treatment, the patient had an arthritis of the left knee. The infectious origin was confirmed by synovial biopsy. The course was better after adaptation of the antibiotics...
October 2005: La Tunisie Médicale
R Perelman, M Nathanson, F Danis, F Hayem, M Gesnu, M Goudal
No abstract text is available yet for this article.
February 1979: Annales de Pédiatrie
Samir Kochbati, Mohamed Ben Miled, Fatma Boussema, Sonia Ktari, Lilia Daoud, Samir Ben Rhouma, Golsom Ben Amor, Ouahida Chérif, Lilia Rokbani
The aim of this study was to assess the effect and safety of leflunomide (LEF) in refractory RA and to review the literature on this subject. A one year prospective study was conducted on a group of patients (n:15). Mean duration disease was 6.46 years. Rhumatoid factor was present in 12 cases. Leflunomide was administered at a dos of 20mg/day following a loading dose of 100mg/day for three days. The efficacy of LEF was evaluated on clinical and biological parameters of RA evolutivity at one, 3, 6, 9 and 12 months...
February 2005: La Tunisie Médicale
Thierry Métayé, Hélène Gibelin, Rémy Perdrisot, Jean-Louis Kraimps
G-protein-coupled receptor kinases (GRKs) interact with the agonist-activated form of G-protein-coupled receptors (GPCRs) to effect receptor phosphorylation and to initiate profound impairment of receptor signalling, or desensitization. GPCRs form the largest family of cell surface receptors known and defects in GRK function have the potential consequence to affect GPCR-stimulated biological responses in many pathological situations. This review focuses on the physiological role of GRKs revealed by genetically modified animals but also develops the involvement of GRKs in human diseases as, Oguchi disease, heart failure, hypertension or rhumatoid arthritis...
August 2005: Cellular Signalling
No abstract text is available yet for this article.
August 1959: Arthritis and Rheumatism
D A Vuitton, B de Wazières, J L Dupond
INTRODUCTION: The concept of "psychoimmunology" that had long been supported by clinical observation and common sense, has acquired a sound scientific basis in the last two decades. The discovery of neuro-mediators and cytokines and their receptors shared by the central nervous system and the immune system has prompted research work using reliable methodologies to study the relationship between a 'hard' scientific field, such as immunology, and a 'soft' one, such as the behavioral sciences...
October 1999: La Revue de Médecine Interne
A Grasland, P Vinceneux
UNLABELLED: THE CONTEXT: Psoriasic arthritis lies somewhere between rhumatoid polyarthritis and spondyloathropathy. Its prevalence is about 0.1% with a 1/1 sex ratio. Mean age at onset of symptoms is 40 years. In 10 to 15% of the cases, rhumatological manifestations are observed before skin lesions. Ungueal involvement is particularly frequent. FIVE CLINICAL FORMS: Classically, five clinical forms are described: arthritis limited to the distal interphalangeal joints, mutilating arthritis, symmetrical polyarthritis, asymmetrical mono- or oligoarthritis, and spondylitis...
June 26, 1999: La Presse Médicale
A Bourrillon
Prolonged fever is defined as an unexplained fever of more than 5 days duration. In infancy and early childhood, it is most often of infectious origin, viral infections being the most frequent. Mycoplasma pneumoniae infections, urinary tract infection and otitis media are also commonly involved. Kawasaki disease is the main inflammatory etiology, juvenile rhumatoïd arthritis in its systemic form (Still's disease) being much rarer. In most cases the etiological diagnosis can be made with a limited number of laboratory and/or imaging investigations based upon a careful clinical evaluation and an oriented chronological strategy...
March 1999: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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