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https://www.readbyqxmd.com/read/28638254/inflammation-and-oxidation-biomarkers-in-patients-with-cystic-fibrosis-the-influence-of-azithromycin
#1
Casilda Olveira, Alicia Padilla, Antonio Dorado, Victoria Contreras, Eduardo Garcia-Fuentes, Elehazara Rubio-Martin, Nuria Porras, Esperanza Doña, Ana Carmona, Gabriel Olveira
OBJECTIVE: In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides. MATERIALS AND METHODS: The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28637060/comparison-of-azithromycin-versus-erythromycin-for-prolongation-of-latency-in-pregnancies-complicated-by-preterm-premature-rupture-of-membranes
#2
Matthew M Finneran, Ashley Appiageyei, Megan Templin, Heather Mertz
No abstract text is available yet for this article.
June 21, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28636757/babesiosis-an-unusual-cause-of-sepsis-after-kidney-transplantation-and-review-of-the-literature
#3
Imtiaz Ather, Negiin Pourafshar, Denise Schain, Asmita Gupte, Michael J Casey
We report a unique case of babesiosis presenting as sepsis after kidney transplantation. A 70-year-old female kidney transplant recipient presented with fever, hemolytic anemia, and acute kidney injury, and met three of four systemic inflammatory response syndrome (SIRS) criteria. Serology was positive for Babesia microti, confirmed by polymerase chain reaction. The patient was treated with atovaquone and azithromycin and made a full recovery. Reports of babesiosis after solid organ transplantation are rare, with only four prior cases reported in the literature...
June 21, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28635638/antibiotic-concentrations-decrease-during-wastewater-treatment-but-persist-at-low-levels-in-reclaimed-water
#4
Prachi Kulkarni, Nathan D Olson, Greg A Raspanti, Rachel E Rosenberg Goldstein, Shawn G Gibbs, Amir Sapkota, Amy R Sapkota
Reclaimed water has emerged as a potential irrigation solution to freshwater shortages. However, limited data exist on the persistence of antibiotics in reclaimed water used for irrigation. Therefore, we examined the fate of nine commonly-used antibiotics (ampicillin, azithromycin, ciprofloxacin, linezolid, oxacillin, oxolinic acid, penicillin G, pipemidic acid, and tetracycline) in differentially treated wastewater and reclaimed water from two U.S. regions. We collected 72 samples from two Mid-Atlantic and two Midwest treatment plants, as well as one Mid-Atlantic spray irrigation site...
June 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28629448/azithromycin-for-idiopathic-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-a-retrospective-single-center-study
#5
Kodai Kawamura, Kazuya Ichikado, Yuko Yasuda, Keisuke Anan, Moritaka Suga
BACKGROUND: Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a fatal condition without an established pharmaceutical treatment. Most patients are treated with high-dose corticosteroids and broad-spectrum antibiotics. Azithromycin is a macrolide with immunomodulatory activity and may be beneficial for treatment of acute lung injury. The objective of this study was to determine the effect of azithromycin on survival of patients with idiopathic AE of IPF. METHODS: We evaluated 85 consecutive patients hospitalized in our department for idiopathic AE of IPF from April 2005 to August 2016...
June 19, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28626822/a-prospective-randomized-trial-of-azithromycin-versus-trimethoprim-sulfamethoxazole-in-treatment-of-toxoplasmic-retinochoroiditis
#6
Alireza Lashay, Ahmad Mirshahi, Najaf Parandin, Hamid Riazi Esfahani, Mehdi Mazloumi, Mohammad Reza Lashay, Mohammad Karim Johari, Elham Ashrafi
PURPOSE: To assess the efficacy of oral azithromycin in the treatment of toxoplasmic retinochoroiditis. METHODS: A randomized interventional comparative study was conducted on 14 patients with ocular toxoplasmosis who were treated with oral azithromycin and 13 patients who were treated with oral trimethoprim/sulfamethoxazole for 6-12 weeks. The achievement of treatment criteria in the two groups and lesion size reduction were considered as primary outcome measures...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28625676/comprehensive-determination-of-macrolide-antibiotics-their-synthesis-intermediates-and-transformation-products-in-wastewater-effluents-and-ambient-waters-by-liquid-chromatography-tandem-mass-spectrometry
#7
Ivan Senta, Ivona Krizman-Matasic, Senka Terzic, Marijan Ahel
Macrolide antibiotics are a prominent group of emerging contaminants frequently found in wastewater effluents and wastewater-impacted aquatic environments. In this work, a novel analytical method for simultaneous determination of parent macrolide antibiotics (azithromycin, erythromycin, clarithromycin and roxithromycin), along with their synthesis intermediates, byproducts, metabolites and transformation products in wastewater and surface water was developed and validated. Samples were enriched using solid-phase extraction on Oasis HLB cartridges and analyzed by reversed-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry...
June 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28625019/efficacy-of-azithromycin-and-compounded-atovaquone-for-treatment-of-babesia-gibsoni-in-dogs
#8
S K Kirk, J K Levy, P C Crawford
BACKGROUND: Approximately one-third of dogs confiscated during dogfighting investigations are infected with Babesia gibsoni. Traditional management of B. gibsoni with polymerase chain reaction (PCR)-screening, treatment with commercially available azithromycin and atovaquone, and PCR testing after 60 and 90 days is costly and impractical for large numbers of dogs at a time. HYPOTHESIS/OBJECTIVES: To assess the efficacy of an alternative protocol in which commercial atovaquone was replaced by compounded medication and PCR monitoring was initiated at 30 days after the end of treatment to decrease the total management time...
June 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28623110/pertussis-without-apparent-cough-in-a-disabled-girl-with-a-tracheostomy
#9
Hisataka Nozawa, Kensuke Shoji, Kazuhiro Uda, Tomoo Nakamura, Mitsuru Kubota, Akira Ishiguro, Isao Miyairi
Pertussis is characterized by intense, prolonged coughing in children often followed by a distinctive whooping sound on inspiration. However, the clinical manifestations and natural course of pertussis in disabled children are largely unknown. We experienced a case of pertussis in a disabled girl who had previously undergone a tracheostomy and laryngotracheal separation. She presented with increased tracheal secretions and required hospitalization but did not develop a cough. Pertussis was suspected from the sputum Gram stain, which revealed numerous, short gram-negative rods that did not grow on chocolate agar...
June 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28619239/antimicrobial-susceptibility-of-haemophilus-influenzae-strains-isolated-from-the-urethra-of-men-with-acute-urethritis-and-or-epididymitis
#10
Takashi Deguchi, Shin Ito, Kyoko Hatazaki, Kengo Horie, Mitsuru Yasuda, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Nozomu Hanaoka, Ken Shimuta, Makoto Ohnishi, Tetsuro Muratani, Masahiro Nakano
We determined minimum inhibitory concentrations (MICs) of 41 antimicrobial agents for 73 clinical strains of Haemophilusinfluenzae isolated from the urethra of men with acute urethritis and/or epididymitis and examined the strains for the production of β-lactamase. We also compared their antimicrobial susceptibilities with those of H. influenzae strains from respiratory tract or otorhinolaryngological infections that were reported in Japan. The proportion of β-lactamase-nonproducing ampicillin-resistant strains from acute urethritis and/or epididymitis appeared to be lower, but that of β-lactamase-producing ampicillin-resistant strains appeared to be higher, compared with those from respiratory tract or otorhinolaryngological infections...
June 12, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28615273/analysis-of-the-potential-for-point-of-care-test-to-enable-individualised-treatment-of-infections-caused-by-antimicrobial-resistant-and-susceptible-strains-of-neisseria-gonorrhoeae-a-modelling-study
#11
Katy Me Turner, Hannah Christensen, Elisabeth J Adams, David McAdams, Helen Fifer, Anthony McDonnell, Neil Woodford
OBJECTIVE: To create a mathematical model to investigate the treatment impact and economic implications of introducing an antimicrobial resistance point-of-care test (AMR POCT) for gonorrhoea as a way of extending the life of current last-line treatments. DESIGN: Modelling study. SETTING: England. POPULATION: Patients accessing sexual health services. INTERVENTIONS: Incremental impact of introducing a hypothetical AMR POCT that could detect susceptibility to previous first-line antibiotics, for example, ciprofloxacin or penicillin, so that patients are given more tailored treatment, compared with the current situation where all patients are given therapy with ceftriaxone and azithromycin...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28614375/burden-of-trachoma-in-five-counties-of-eastern-equatoria-state-south-sudan-results-from-population-based-surveys
#12
Angelia M Sanders, Aisha E P Stewart, Samuel Makoy, Joy J Chebet, Peter Magok, Aja Kuol, Carla Blauvelt, Richard Lako, John Rumunu, E Kelly Callahan, Scott D Nash
BACKGROUND: In order to decrease the prevalence of trachoma within the country, the Republic of South Sudan has implemented components of the SAFE strategy in various counties since 2001. Five counties in Eastern Equatoria state were surveyed in order to monitor progress of programmatic interventions and determine if additional rounds of Mass Drug Administration with azithromycin were needed. METHODOLOGY/ PRINCIPAL FINDINGS: Five counties (Budi, Lafon, Kapoeta East, Kapoeta South and Kapoeta North) were surveyed from April to October 2015...
June 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28614157/probable-donor-derived-cytomegalovirus-disease-after-keratolimbal-allograft-transplantation
#13
Albert Y Cheung, Amit Govil, Scott R Friedstrom, Edward J Holland
PURPOSE: To report a case of probable donor-derived cytomegalovirus (CMV) infection after keratolimbal allograft (KLAL) transplantation. METHODS: Observational case report. RESULTS: A 41-year-old man with a history of aniridic keratopathy and limbal stem cell deficiency underwent KLAL in his right eye. Preoperatively, he was negative for CMV IgG and IgM. Postoperatively, he was maintained on tacrolimus and mycophenolate mofetil for systemic immunosuppression; he was also on prophylactic valganciclovir (for CMV) and trimethoprim/sulfamethoxazole (for pneumocystis pneumonia) for 1 month...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28613983/azithromycin-attenuates-myofibroblast-differentiation-and-lung-fibrosis-development-through-proteasomal-degradation-of-nox4
#14
Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Nahoko Sato, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Yoichi Nakanishi, Kazuyoshi Kuwano
Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB (transforming growth factor beta) is one of the major profibrotic cytokines for myofibroblast differentiation and NOX4 (NADPH oxidase 4) has an essential role in TGFB-mediated cell signaling. Azithromycin (AZM), a second-generation antibacterial macrolide, has a pleiotropic effect on cellular processes including proteostasis. Hence, we hypothesized that AZM may regulate NOX4 levels by modulating proteostasis machineries, resulting in inhibition of TGFB-associated lung fibrosis development...
June 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28608791/biological-and-behavioral-factors-associated-with-positive-chlamydia-retests
#15
Kirsty S Smith, Rebecca Guy, Jennifer Danielewski, Sepehr N Tabrizi, Christopher K Fairley, Anna M McNulty, William Rawlinson, Marion Saville, Suzanne M Garland, Basil Donovan, John M Kaldor, Jane S Hocking
BACKGROUND: Repeat chlamydia detection after treatment is common, and there is concern that treatment failure may be a cause. METHODS: Within a randomized trial, we established a prospective cohort of 600 participants with anogenital chlamydia diagnoses (200 each of women, heterosexual men, and men who have sex with men [MSM]). Participants were invited for repeat testing at 3 months and to complete a behavioral survey at 4 months. Positive samples were analyzed for organism DNA load and genovar...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28605219/retraction-of-azithromycin-1-5-ophthalmic-solution-for-blepharitis-treatment-comparison-of-14-versus-30-day-treatment-doi-10-1089-jop-2015-0099
#16
(no author information available yet)
No abstract text is available yet for this article.
June 12, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28604482/azithromycin-efficacy-in-asymptomatic-rectal-chlamydial-infection-in-men-who-have-sex-with-men-a-more-definitive-answer-soon
#17
Byron E Batteiger
No abstract text is available yet for this article.
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28601926/antibiotic-resistance-genes-and-antibiotic-susceptibility-of-oral-enterococcus-faecalis-isolates-compared-to-isolates-from-hospitalized-patients-and-food
#18
Annette Carola Anderson, Huria Andisha, Elmar Hellwig, Daniel Jonas, Kirstin Vach, Ali Al-Ahmad
Enterococcus faecalis, a commensal of the intestinal tract of humans and animals is of great significance as leading opportunistic pathogen, and also prevalent in oral diseases, such as endodontic infections, as well as the healthy oral cavity. To investigate the potential of oral E. faecalis to constitute a reservoir of antibiotic resistance, isolates from supragingival plaque/saliva and from endodontic infections were screened regarding their resistance to selected antibiotics in comparison to nosocomial and food isolates...
June 11, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28598854/analysis-of-azithromycin-monohydrate-as-a-single-or-a-combinatorial-therapy-in-a-mouse-model-of-severe-spinal-muscular-atrophy
#19
Erkan Y Osman, Charles W Washington, Madeline E Simon, Dalia Megiddo, Dalia Hagar Greif, Christian L Lorson
BACKGROUND: Spinal muscular atrophy (SMA) is a neurodegenerative autosomal recessive disorder characterized by the loss of α-motor neurons. A variety of molecular pathways are being investigated to elevate SMN protein expression in SMA models and in the clinic. One of these approaches involves stabilizing the SMNΔ7 protein by inducing translational read-through. Previous studies have demonstrated that functionality and stability are partially restored to the otherwise unstable SMNΔ7 by the addition of non-specific C-terminal peptide sequences, or by inducing a similar molecular event through the use of read-through inducing compounds such as aminoglycosides...
June 9, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28596950/review-quality-of-life-in-children-with-non-cystic-fibrosis-bronchiectasis
#20
REVIEW
Anna Marie Nathan, Jessie Anne de Bruyne, Kah Peng Eg, Surendran Thavagnanam
Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-powered, randomized controlled trials to guide clinicians how to manage NCFB effectively. Quality-of-life (QOL) measures in NCFB are an important aspect of clinical care that has not been studied well...
2017: Frontiers in Pediatrics
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