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https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#1
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29770731/antibiotics-mineralization-by-electrochemical-and-uv-based-hybrid-processes-evaluation-of-the-synergistic-effect
#2
Salatiel Wohlmuth da Silva, Alan Nelson Arenhart Heberle, Alexia Pereira Santos, Marco Antônio Siqueira Rodrigues, Valentín Pérez-Herranz, Andréa Moura Bernardes
Antibiotics are not efficiently removed in conventional wastewater treatments. In fact, different Advanced Oxidation Process (AOPs), including ozone, peroxide, UV radiation, among others, are being investigated in the elimination of microcontaminants. Most of AOPs proved to be efficient on the degradation of antibiotics, but the mineralization is on the one hand not evaluated or on the other hand not high. At this work, the UV-based hybrid process, namely Photo-assisted electrochemical Oxidation (PEO), was applied aiming the mineralization of microcontaminants such as the antibiotics Amoxicillin (AMX), Norfloxacin (NOR) and Azithromycin (AZI)...
May 17, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29768565/cat-scratch-disease-presenting-as-axillary-lymphadenopathy-and-a-palpable-benign-mammary-nodule-mimicking-a-carcinoma
#3
Larissa Cabral Marques, Kátia Pincerato, Adriana Akemi Yoshimura, Felipe Eduardo Martins Andrade, Alfredo Carlos Simões Dornellas de Barros
We present a case involving a 74-year-old woman with cat scratch disease characterized by an enlarged and hard axillary lymph node as well as a palpable breast nodule mimicking a carcinoma. The lymph node and the breast nodule were excised. The pathologic examinations revealed granulomatous lymphadenitis with gram-negative bacilli and an intraductal papilloma. Antibiotic therapy (azithromycin) was prescribed and the patient's clinical evolution was excellent.
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29755754/-chlamydia-pneumoniae-induced-tumour-necrosis-factor-alpha-responses-are-lower-in-children-with-asthma-compared-with-non-asthma
#4
Tamar Anne Smith-Norowitz, Kobkul Chotikanatis, Diana Weaver, Jared Ditkowsky, Yitzchok Meir Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Introduction: Chlamydia pneumoniae respiratory tract infection has been implicated in the pathogenesis of reactive airway disease and asthma. Innate cytokine responses that are protective of infection with intracellular pathogens may be impaired in patients with asthma. Tumour necrosis factor alpha (TNF-α) is a cytokine related to functions of monocytes and may inhibit C. pneumoniae infection. We investigated TNF-α responses in C. pneumoniae -infected peripheral blood mononuclear cells (PBMCs) in patients with asthma and non-asthma, and whether ciprofloxacin, azithromycin or doxycycline affects TNF-α responses...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29755617/regulation-of-defensive-function-on-gingival-epithelial-cells-can-prevent-periodontal-disease
#5
REVIEW
Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara
Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacterial invasion and a part of the innate immune response to infectious inflammation in periodontal tissue. The disorganization of cell-cell interactions and subsequent inflammation contribute to the initiation of periodontal disease...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29751244/behavior-of-tetracycline-and-macrolide-antibiotics-in-activated-sludge-process-and-their-subsequent-removal-during-sludge-reduction-by-ozone
#6
Lu Wang, Weiwei Ben, Yangang Li, Chao Liu, Zhimin Qiang
Ozonation is a promising means for the reduction of excess sludge in wastewater treatment plants. However, little information is available on the removal of antibiotics during sludge ozonation. Therefore, this study investigated first the behavior of four commonly-used hydrophobic antibiotics, including three tetracyclines (tetracycline, oxytetracycline, and doxycycline) and one macrolide (azithromycin) in activated sludge process and then their removal during sludge reduction by ozone. Results indicate that the studied antibiotics were primarily transferred into the solid phase of activated sludge via sorption, which was a reversible, spontaneous, and exothermic process governed by surface reactions...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29747680/first-report-of-cytauxzoon-sp-infection-in-domestic-cats-in-switzerland-natural-and-transfusion-transmitted-infections
#7
Alice Nentwig, Marina L Meli, Johanna Schrack, Iris M Reichler, Barbara Riond, Corinne Gloor, Judith Howard, Regina Hofmann-Lehmann, Barbara Willi
BACKGROUND: Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids. Cytauxzoon felis induces severe and often fatal disease in domestic cats. In Europe, clinical and subclinical infections caused by Cytauxzoon sp. are described. We report the first cases of Cytauxzoon sp. infection in domestic cats in Switzerland. METHODS: Clinical and laboratory data and results of PCR analyses were collected from Cytauxzoon sp. PCR-positive cats and the cats followed for up to 851 days...
May 10, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29740931/antimicrobial-prescription-in-patients-dying-from-chronic-obstructive-pulmonary-disease
#8
John Taverner, Lauren Ross, Claire Bartlett, M Luthe, J Ong, Louis Irving, Natasha Smallwood
INTRODUCTION: Despite rising antimicrobial resistance, treatment guidelines for COPD exacerbations are frequently ignored. Patients with terminal conditions are often prescribed antimicrobials despite the goal of care to reduce burdensome treatments. The appropriateness of antimicrobials in patients dying from an exacerbation of COPD is unknown. AIM: To review antimicrobial prescription at the time of death in patients who died from COPD. METHODS: A retrospective medical record audit was performed for 475 patients who died over twelve years (2004-2015)...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29738438/proctitis-caused-by-mycobacterium-avium-intracellulare-in-an-hiv-infected-patient
#9
Jose Armando Gonzales Zamora, Clara Milikowski
Infectious proctitis is usually associated with sexually transmitted diseases, especially in HIV-infected individuals. Limited information is found about the role of Mycobacterium avium-intracellulare as a causative agent for this condition. Here, we report the case of an HIV-infected patient with a CD4 count of 304 cells/uL and undetectable HIV viral load, who presented with constipation and painful defecation. Endoscopic evaluation was significant for shallow rectal ulcerations. Histopathology revealed poorly formed granulomas...
May 8, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29735830/changing-trends-of-culture-positive-typhoid-fever-and-antimicrobial-susceptibility-in-a-tertiary-care-north-indian-hospital-over-the-last-decade
#10
Priyanka Sharma, Sushila Dahiya, Neelam Manral, Bhavana Kumari, Sambuddha Kumar, Sangeeta Pandey, Seema Sood, Bimal Kumar Das, Arti Kapil
Purpose: The present study was undertaken to analyse the trend in prevalence of culture-positive typhoid fever during the last decade and to determine antimicrobial susceptibility profile of Salmonella Typhi and Salmonella Paratyphi A isolated from patients of enteric fever presenting to our hospital. Methods: All the culture-positive enteric fever cases during 2005-2016 presenting to our Hospital were included in the study. Antimicrobial susceptibility was done against chloramphenicol, amoxicillin, co-trimoxazole, ciprofloxacin, ofloxacin, levofloxacin, pefloxacin, ceftriaxone and azithromycin as per corresponding CLSI guidelines for each year...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735563/natamycin-and-azithromycin-are-synergistic-in-vitro-against-ocular-pathogenic-aspergillus-flavus-species-complex-and-fusarium-solani-species-complex-isolates
#11
Haoyi Guo, Lutan Zhou, Yi He, Chuanwen Gao, Lei Han, Yan Xu
The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested in vitro The combination produced 100% synergistic interactions when natamycin added azithromycin at 20, 40, 50 μg/ml against Aspergillus flavus species complex (AFSC) isolates and added azithromycin at 50 μg/ml against Fusarium solani species complex isolates. The combination with 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MICs from MIC90 64μg/ml to MIC90 0...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29734778/antibiotic-sensitivity-profiling-and-virulence-potential-of-campylobacter-jejuni-isolates-from-estuarine-water-in-the-eastern-cape-province-south-africa
#12
Anthony C Otigbu, Anna M Clarke, Justine Fri, Emmanuel O Akanbi, Henry A Njom
Campylobacter jejuni (CJ) is a zoonotic microbe and a major causative organism of diarrheal infection in humans that often has its functional characteristics inactivated in stressed conditions. The current study assessed the correlation between recovered CJ and water quality parameters and the drug sensitivity patterns of the pathogen to frontline antibiotics in human and veterinary medicine. Water samples ( n = 244) from rivers/estuarines were collected from April⁻September 2016, and physicochemical conditions were recorded on-site...
May 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29733738/case-study-a-combination-of-mepolizumab-and-omaluzimab-injections-for-severe-asthma
#13
Rejmon Dedaj, Lindie Unsel
A Combination of Mepolizumab and Omaluzimab injections for severe asthma. INTRODUCTION: Patients with severe persistent asthma account for a large proportion of asthma morbidity and health care expenditures. In this case report we describe the use of a combination of omalizumab and mepolizumab in severe asthma with elevated IgE levels and eosinophilic phenotype. CASE STUDY: We are treating a 55 year old woman with severe persistent eosinophilic asthma and elevated IgE levels...
May 7, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29731947/patterns-of-antibiotic-prescription-in-children-tirana-albania-region
#14
Joana Mihani, Suela Këlliçi
BACKGROUND: Antibiotics (abx) constitute the most prescribed therapeutic agent in the world. There is little data regarding antibiotic consumption by young children in Albania. AIM: This study aims to evaluate antibiotic prescription in children in quantitative and qualitative terms, and therefore, propose recommendations to improve overall clinical outcomes. METHODS: A retrospective, cross-sectional drug utilisation study was conducted based on unreimbursed prescriptions collected in 25 pharmacies, randomly selected within the district of Tirana, during the period beginning December 2015 to January 2016...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731649/comparative-evaluation-of-methods-for-the-detection-of-biofilm-formation-in-coagulase-negative-staphylococci-and-correlation-with-antibiogram
#15
Lok Bahadur Shrestha, Narayan Raj Bhattarai, Basudha Khanal
Introduction: Coagulase-negative staphylococci (CNS) are normal commensals of human skin and mucous membranes. The objective of the study was to determine the prevalence of CNS among clinical isolates, characterize them up to species level, compare the three conventional methods for detection of biofilm formation, and study their antimicrobial susceptibility pattern. Materials and methods: CNS were obtained from various clinical samples including blood, urine, central venous catheter tips, endotracheal tube aspirate, and pus during a 1-year period (July 1, 2014, to June 30, 2015)...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29730195/transient-myocardial-thickening-in-a-bartonella-henselae-positive-cat
#16
J L Joseph, E M Oxford, R A Santilli
A 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, and 3.5 ng/mL, sequentially every 12 h)...
May 2, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29729515/pharmaceutically-active-compounds-in-the-xiangjiang-river-china-distribution-pattern-source-apportionment-and-risk-assessment
#17
Huiju Lin, Leilei Chen, Haipu Li, Zhoufei Luo, Jing Lu, Zhaoguang Yang
The occurrence of 36 pharmaceutically active compounds in surface water of the Xiangjiang River was investigated in two seasons (n = 38). Twenty-five of these compounds were detected, with cefotaxime (maximum concentration 830 ng L-1 ) the most abundant compound followed by amoxicillin (maximum concentration 710 ng L-1 ). The spatiotemporal distribution was observed; indicating that pollution hotspots were mostly located in economically developed and densely populated regions such as Changsha City...
May 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29726994/treatment-of-human-challenge-and-mdr-strains-of-neisseria-gonorrhoeae-with-lpxc-inhibitors
#18
Constance M John, Dongxiao Feng, Gary A Jarvis
Objectives: Inhibitors of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), which catalyses the second step in the biosynthesis of lipid A, have been developed as potential antibiotics for Gram-negative infections. Our objectives were to determine the effect of LpxC inhibition on the in vitro survival and inflammatory potential of Neisseria gonorrhoeae. Methods: Survival of four human challenge strains was determined after treatment with two LpxC inhibitors for 2 and 4 h...
May 2, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29726858/photo-rounds-generalized-pustular-eruption
#19
Stanislav N Tolkachjov, David A Wetter, Benjamin J Sandefur
The timing of a recent prescription for azithromycin and the morphology of this eruption made us suspect a drug reaction. But which type of reaction were we looking at?
May 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29726648/-effects-of-zhibai-dihuang-decoction-on-mitochondrial-cytochrome-oxidase-in-the-spermatogenic-cells-of-rats-with-ureaplasma-urealyticum-infection
#20
Jun-Hua Guo, Ying-Qiu Li, Xuan-Zuo Guo, Chao-Sheng Liu, Qing-Hu He
Objective: To explore the effects of Zhibai Dihuang Decoction (ZDD) on mitochondrial cytochrome oxidase (COX) in the spermatogenic cells of rats with ureaplasma urealyticum (UU) infection. METHODS: From forty 4-5 months old SD rats, 30 were randomly selected for the establishment of the model of testicular UU infection by inoculating the bladder with UU suspension and the other 10 injected with normal saline as controls (group A). At 7 days after inoculation, the rat models of testicular UU infection were treated orally with normal saline (group B), ZDD at 1 g per kg of the body weight per day (group C), and azithromycin at 0...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
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