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https://www.readbyqxmd.com/read/29468757/anxiolytic-and-antidepressant-activities-of-pelargonium-roseum-essential-oil-on-swiss-albino-mice-possible-involvement-of-serotonergic-transmission
#1
Mohaddeseh Abouhosseini Tabari, Akbar Hajizadeh Moghaddam, Filippo Maggi, Giovanni Benelli
The anxiolytic and antidepressant activities of the Reunion Geranium (Pelargonium roseum Willd) essential oil (EO) were evaluated in male Swiss albino mice by intraperitoneal administration of 10, 20, and 50 mg/kg bw using elevated plus maze (EPM), open-field test (OFT), and forced swimming test (FST). Moreover, we evaluated whether the 5-HT1A and GABAA -benzodiazepine receptor systems are involved in the anxiolytic effects through the coadministration of WAY-100635 (a selective 5-HT1A receptor antagonist) and flumazenil (an antagonist of benzodiazepine)...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29457121/anesthesia-for-patients-with-ptrf-mutations-a-case-report
#2
Atsuko Hirano, Tomohiko Takada, Mariko Senda, Hidemasa Takahashi, Takeo Suzuki
Background: Polymeraze I and transcript release factor ( PTRF ) mutations are a newly recognized disease, which cause congenital generalized lipodystrophy associated with myopathy. Case presentation: A 29-year-old man (height 126 cm; weight 22 kg) with a PTRF mutation was scheduled for mandibular dentigerous cystectomy. His primary symptoms were lipodystrophy, myopathy, long QT syndrome, refractory nephrosis, and abnormal lipid metabolism. Defibrillator pads were applied soon after the patient entered the operating room...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29414121/sacred-maya-incense-copal-protium-copal-burseraceae-has-antianxiety-effects-in-animal-models
#3
Zul Merali, Christian Cayer, Pamela Kent, Rui Liu, Victor Cal, Cory S Harris, John T Arnason
ETHNOPHARMACOLOGICAL RELEVANCE: The Maya have traditionally used copal, Protium copal, as incense during ceremonies since pre-Columbian times. Anecdotally, copal (when burned as incense), is thought to elicit mentally uplifting and calming effects. The main objective of this study was to determine whether the incense elicits anxiolytic-like behavior in animal models using rats. A second objective was to characterize active constituents and discern potential mechanism(s) of action, specifically the involvement of the GABAergic and endocannabinoid (eCB) systems...
January 29, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29413823/automated-radiosynthesis-and-purification-of-18f-flumazenil-with-solid-phase-extraction
#4
Daria Vaulina, Morteza Nasirzadeh, Natalia Gomzina
This paper describes the novel approach for preparation of [18F]flumazenil ([18F]FMZ), well known radioligand for assessment of GABAA receptors by PET. The optimized reaction conditions allowed us to implement commercially available SPE cartridges for [18F]FMZ purification avoiding HPLC. All procedures were performed with TRACERlab FX N Pro synthesizer in 53 min. Developed approach provided [18F]FMZ with high RCP (> 97%) and low level of chemical impurities (< 5 µg/mL). FMZ was routinely synthesized in 6...
January 25, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29374303/negative-allosteric-modulation-of-alpha-5-containing-gabaa-receptors-engenders-antidepressant-like-effects-and-selectively-prevents-age-associated-hyperactivity-in-tau-depositing-mice
#5
Nina Z Xu, Margot Ernst, Marco Treven, Rok Cerne, Mark Wakulchik, Xia Li, Timothy M Jones, Scott D Gleason, Denise Morrow, Jeffrey M Schkeryantz, Md Toufiqur Rahman, Guanguan Li, Michael M Poe, James M Cook, Jeffrey M Witkin
RATIONALE: Associated with frank neuropathology, patients with Alzheimer's disease suffer from a host of neuropsychiatric symptoms that include depression, apathy, agitation, and aggression. Negative allosteric modulators (NAMs) of α5-containing GABAA receptors have been suggested to be a novel target for antidepressant action. We hypothesized that pharmacological modulation of this target would engender increased motivation in stressful environments. METHODS: We utilized electrophysiological recordings from Xenopus oocytes and behavioral measures in mice to address this hypothesis...
January 26, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29372452/hibiscus-rosa-sinensis-mediate-anxiolytic-effect-via-modulation-of-ionotropic-gaba-a-receptors-possible-mechanism-of-action
#6
Zubia Begum, Ishrat Younus
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (p < 0.05) increased the number of head dips and rearings as compared to control on respective days of observation...
January 25, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29359856/efficacy-and-safety-of-flumazenil-injection-for-the-reversal-of-midazolam-sedation-after-elective-outpatient-endoscopy
#7
Sang Pyo Lee, In-Kyung Sung, Jeong Hwan Kim, Sun-Young Lee, Hyung Seok Park, Chan Sup Shim
OBJECTIVE: Midazolam sedation during elective endoscopy is widely performed, and flumazenil is frequently administered after endoscopy for the reversal of sedation in clinical practice. This study aimed to investigate the safety and efficacy of flumazenil injection after elective endoscopy under midazolam sedation. METHODS: Patients who underwent upper endoscopy under midazolam sedation were randomly divided into two groups. In group I, flumazenil was intravenously administered 10 min after patient transfer to a recovery room, and no antidote was injected in group II...
January 23, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29297158/correction-to-parametric-imaging-of-11c-flumazenil-binding-in-the-rat-brain
#8
Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Ana Maria Marques da Silva, Michel Koole, Rudi Dierckx, Antoon Willemsen, Ronald Boellaard
The name of the second author was incorrectly cited and is corrected now, as displayed here.
January 2, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29286356/is-flumazenil-an-alternative-for-the-treatment-of-hepatic-encephalopathy
#9
Diego Reyes, Francisco Barrera
INTRODUCTION: Flumazenil is an antagonist of the GABA/benzodiazepines receptor complex that might play a role in the treatment of hepatic encephalopathy. However, its efficacy and safety are a matter of debate. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
December 26, 2017: Medwave
https://www.readbyqxmd.com/read/29274881/neurobiological-mechanisms-of-antiallodynic-effect-of-transcranial-direct-current-stimulation-tdcs-in-a-mice-model-of-neuropathic-pain
#10
Andressa de Souza, Daniel F Martins, Liciane Fernandes Medeiros, Catharina Nucci, Thiago César Martins, Aline Siteneski, Wolnei Caumo, Adair Roberto Soares Dos Santos, Iraci L S Torres
BACKGROUND: Neuropathic pain is relatively common and occurs in approximately 6-8% of the population. It is associated with allodynia and hyperalgesia. Thus, non-pharmacological treatments, such as transcranial direct current stimulation (tDCS) may be useful for relieving pain. OBJECTIVES: This study aimed to investigate the antiallodynic effect of tDCS in a mice model of neuropathic pain, and the underlying neurotransmission systems that could drive these effects...
December 21, 2017: Brain Research
https://www.readbyqxmd.com/read/29232839/agarwood-essential-oil-displays-sedative-hypnotic-effects-through-the-gabaergic-system
#11
Shuai Wang, Canhong Wang, Deqian Peng, Xinmin Liu, Chongming Wu, Peng Guo, Jianhe Wei
Although agarwood has been used as a tranquilizer in Asian countries for hundreds of years, the underlying pharmacological basis is still unclear. This study investigated the sedative-hypnotic effect of agarwood essential oil (AEO) using locomotor activity and pentobarbital-induced sleeping assays in mice. Single (1-day) and multiple (7- and 14-days) administrations of 60 mg/kg AEO generated significant sedative effect on inhibiting locomotor activity and hypnotic effect on pentobarbital-induced sleeping in mice...
December 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29217165/anxiolytic-and-antidepressant-like-activities-of-a-methanolic-extract-of-morinda-citrifolia-linn-noni-fruit-in-mice-involvement-of-benzodiazepine-gabaaergic-serotonergic-and-adrenergic-systems
#12
Megala Narasingam, Kamini Vijeepallam, Zahurin Mohamed, Vijayapandi Pandy
This study presents anxiolytic- and antidepressant-like effects of a methanolic extract of Morinda citrifolia Linn. (noni) fruit (MMC) in well-established mouse models of anxiety and depression. The administration of MMC (1 g/kg, p.o.) and diazepam (1 mg/kg, i.p.) significantly attenuated anxiety-like behaviour in mice by increasing the percentage of time spent and number of entries in the open arms in the elevated plus maze (EPM), and significantly enhanced the exploration in the light box in the light/dark test (LDT)...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29201257/muscle-power-during-intravenous-sedation
#13
REVIEW
Nobuyuki Matsuura
Intravenous sedation is effective to reduce fear and anxiety in dental treatment. It also has been used for behavior modification technique in dental patients with special needs. Midazolam and propofol are commonly used for intravenous sedation. Although there have been many researches on the effects of midazolam and propofol on vital function and the recovery profile, little is known about muscle power. This review discusses the effects of intravenous sedation using midazolam and propofol on both grip strength and bite force...
November 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29191578/gastrin-releasing-peptide-attenuates-fear-memory-reconsolidation
#14
A Murkar, P Kent, C Cayer, J James, Z Merali
BACKGROUND: Gastrin Releasing Peptide (GRP) may play a role in fear learning. The GRP Receptor is expressed in the basolateral amygdala and hippocampus, and central administration of GRP mediates fear learning. The effects of GRP on reconsolidation, however, have been minimally explored. Reconsolidation, the process by which formed memories are rendered labile following recall, provides a window of opportunity for pharmacological intervention. Although evidence suggests the window of opportunity to alter reactivated consolidation memory can be as long as 6h, shorter intervals have not been extensively investigated...
November 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29184482/identification-of-candidate-allosteric-modulators-of-the-m1-muscarinic-acetylcholine-receptor-which-may-improve-vagus-nerve-stimulation-in-chronic-tinnitus
#15
Tijana Bojić, Vladimir R Perović, Milan Senćanski, Sanja Glišić
Chronic tinnitus is characterized by neuroplastic changes of the auditory cortex. A promising method for therapy of chronic tinnitus is vagus nerve stimulation (VNS) combined with auditory stimulation. The principle of VNS is reversal of pathological neuroplastic changes of the auditory cortex toward physiological neural activity and synchronicity. The VNS mechanism of action in chronic tinnitus patients is prevailingly through the muscarinic neuromodulation of the auditory cortex by the activation of nc. basalis Meynerti...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29183747/anticonvulsant-effect-of-the-hydroethanolic-leaf-extract-of-psydrax-subcordata-dc-bridson-in-murine-models
#16
Samuel Daanaa, Wonder Kofi Mensah Abotsi, Eric Boakye-Gyasi, Eric Woode
ETHNOPHARMACOLOGICAL RELEVANCE: Psydrax subcordata (DC.) Bridson is a tropical medicinal plant used traditionally for the management of epilepsy. However, there is little scientific evidence to support its use. AIM OF STUDY: The current study investigated the anticonvulsant properties of the hydroethanolic leaf extract of Psydrax subcordata (PSE) in animal models. MATERIALS AND METHODS: The anticonvulsant effects were evaluated in mouse models of acute seizures (pentylenetetrazole-, picrotoxin-, 4-aminopyridine-, strychnine- and maximal electroshock-induced seizure tests) and status epilepticus (Lithium/pilocarpine-induced SE)...
November 25, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29183278/capnography-sensor-use-is-associated-with-reduction-of-adverse-outcomes-during-gastrointestinal-endoscopic-procedures-with-sedation-administration
#17
Michael W Jopling, Jiejing Qiu
BACKGROUND: Evidence to date suggests that capnography monitoring during gastrointestinal endoscopic procedures (GEP) reduces the incidence of hypoxemia, but the association of capnography monitoring with the incidence of other adverse outcomes surrounding these procedures has not been well studied. Our aims were to estimate the incidence of pharmacological rescue events and death at discharge from an inpatient or outpatient hospitalization where GEP was performed with sedation, and to determine if capnography monitoring was associated with reduced incidence of these adverse outcomes...
November 28, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29142147/accidental-afloqualone-intoxication-in-two-dogs
#18
Jin-Ok Ahn, Won-Joung Jaung, Sang-Heum Won, Min-Ok Ryu, Woo-Jin Song, Kee-Ok Jeon, Jin-Young Chung, Hwa-Young Youn
Two dogs presented to the emergency service after accidental ingestion of afloqualone tablets, a muscle relaxant used for back pain in humans. Toxic effects of the drug in these dogs included vomiting, respiratory depression, seizures, ataxia, bradycardia, and hematuria. Treatment consisted of fluid diuresis, furosemide, and propofol. Flumazenil, a gamma-amino butyric acid antagonist, was administered intravenously; however, it was not effective in stopping the seizures in these dogs. Both dogs recovered with supportive treatment...
November 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29113874/effect-of-single-doses-of-pindolol-and-d-fenfluramine-on-flumazenil-induced-anxiety-in-panic-disorder-patients
#19
M Bernik, R T Ramos, L A B Hetem, F Graeff
The effects of the 5-HT1A receptor blocker pindolol and the 5-HT releasing and uptake blocking agent d-fenfluramine, both used as indirect serotonin agonists, on flumazenil-induced acute anxiety reactions were studied in panic disorder patients to test the hypothesis that serotonin (5-HT) inhibits neural systems mediating panic attacks. Thirty never treated or drug free PD patients (16 females) aged 22-49 y (mean±SD, 32.9±8) received single doses of d-fenfluramine (n=10; 30mg, p.o.), pindolol (n=10; 5mg, p...
November 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29069225/monoterpenoids-thymol-carvacrol-and-s-linalool-with-anesthetic-activity-in-silver-catfish-rhamdia-quelen-evaluation-of-acetylcholinesterase-and-gabaergic-activity
#20
A E Bianchini, Q I Garlet, J A da Cunha, G Bandeira, I C M Brusque, J Salbego, B M Heinzmann, B Baldisserotto
This study evaluated the anesthetic potential of thymol and carvacrol, and their influence on acetylcholinesterase (AChE) activity in the muscle and brain of silver catfish (Rhamdia quelen). The AChE activity of S-(+)-linalool was also evaluated. We subsequently assessed the effects of thymol and S-(+)-linalool on the GABAergic system. Fish were exposed to thymol and carvacrol (25, 50, 75, and 100 mg/L) to evaluate time for anesthesia and recovery. Both compounds induced sedation at 25 mg/L and anesthesia with 50-100 mg/L...
October 19, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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