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https://www.readbyqxmd.com/read/29670567/gaba-a-receptor-availability-changes-underlie-symptoms-in-isolated-cervical-dystonia
#1
Brian D Berman, Rebecca Tran Pollard, Erika Shelton, Ramesh Karki, Peter M Smith-Jones, Yubin Miao
GABAA receptor availability changes within sensorimotor regions have been reported in some isolated forms of dystonia. Whether similar abnormalities underlie symptoms in cervical dystonia is not known. In the present study, a total of 15 cervical dystonia patients and 15 age- and sex-matched controls underwent 11 C-flumazenil PET/CT scanning. The density of available GABAA receptors was estimated using a Simplified Reference Tissue Model 2. Group differences were evaluated using a two-sample T -test, and correlations with dystonia severity, as measured by the Toronto Western Spasmodic Torticollis Rating Scale, and disease duration were evaluated using a regression analysis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29627297/neuropharmacological-effects-of-essential-oil-from-the-leaves-of-croton-conduplicatus-kunth-and-possible-mechanisms-of-action-involved
#2
Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly Alves Ferraz, Juliane Cabral Silva, Roxana Braga de Andrade Teles, Mariana Gama E Silva, Tâmara Coimbra Diniz, Uiliane Soares Dos Santos, Ana Valéria Vieira de Souza, Carlos Eduardo Pereira Nunes, Marcos José Salvador, Vitor Prates Lorenzo, Lucindo José Quintans Junior, Jackson Roberto Guedes da Silva Almeida
ETHNOPHARMACOLOGICAL RELEVANCE: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as "quebra-faca". In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches. AIM OF THE STUDY: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia...
April 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29615898/antihyperalgesic-properties-of-honokiol-in-inflammatory-pain-models-by-targeting-of-nf-%C3%AE%C2%BAb-and-nrf2-signaling
#3
Sidra Khalid, Muhammad Z Ullah, Ashraf U Khan, Ruqayya Afridi, Hina Rasheed, Adnan Khan, Hussain Ali, Yeong S Kim, Salman Khan
The present study investigates the possible anti-nociceptive effect of intraperitoneal (i.p.) honokiol: a phenolic compound originally isolated from Magnolia officinalis , in acute and chronic inflammatory pain models. Doses of 0.1, 5, and 10 mg/kg honokiol were administered in carrageenan induced pain and the dose (honokiol 10 mg/kg i.p.) with most significant response among behavioral tests was selected for further experiments. The i.p. administration of honokiol inhibits mechanical hyperalgesia, mechanical allodynia, and thermal hyperalgesia, without causing any apparent toxicity...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29573147/anxiolytic-effect-of-anacardic-acids-from-cashew-anacardium-occidentale-nut-shell-in-mice
#4
Antonio Luiz Gomes Júnior, Jana Dimitrova Tchekalarova, Keylla da Conceição Machado, Arkellau Kenned Silva Moura, Márcia Fernanda Correia Jardim Paz, Ana Maria Oliveira Ferreira da Mata, Tiago Rocha Nogueira, Muhammad Torequl Islam, Maria Alexsandra de Sousa Rios, Antônia Maria das Graças Lopes Citó, Shaikh Jamal Uddin, Jamil A Shilpi, Asish K Das, Luciano da Silva Lopes, Ana Amélia de Carvalho Melo-Cavalcante
Antianxiety drugs currently in use are associated with a number of serious side effects. Present study was designed to evaluate the efficacy of anacardic acids (AAs) isolated from cashew nut (Anacardium occidentale L.) shell liquid (CNSL) to treat anxiety as well as its role in oxidative stress in mice model. Anxiolytic effect of AA was evaluated using rota-rod and a set of behavioral tests in male Swiss albino mice at the doses of 10, 25, and 50 mg/kg. Flumazenil was used to evaluate the possible involvement of GABAergic system in the mechanism of action of AA...
March 23, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29572072/effects-of-isopentyl-ferulate-on-oxidative-stress-biomarkers-and-a-possible-gabaergic-anxiolytic-like-trait-in-swiss-mice
#5
Keylla da Conceição Machado, George Layson da Silva Oliveira, Md Torequl Islam, Antonia Amanda Cardoso de Almeida, Damião Pergentino de Sousa, Ana Amélia de Carvalho Melo Cavalcante, Rivelilson Mendes de Freitas
This study aimed to evaluate the anxiolytic-like effect and the possible neuronal mechanism of action of isopentyl ferulate (IF). For this purpose, we used the marble burying test in Swiss albino mice. The biomarkers involved in oxidative stress were measured in the hippocampus homogenate of the test animals. In addition, the toxicity and antioxidant capacities were tested in Artemia salina and rat erythrocytes, respectively. The results suggest that, an acute administration of the IF at doses of 25, 50, 75 and 150 mg/kg (intraperitoneal, i...
March 20, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29555147/evaluation-of-sedative-and-antinociceptive-effects-of-dexmedetomidine-midazolam-and-dexmedetomidine-midazolam-in-tegus-salvator-merianae
#6
Shayne P Bisetto, Cristiano F Melo, Adriano B Carregaro
OBJECTIVE: To evaluate dexmedetomidine, midazolam and dexmedetomidine-midazolam for sedation and antinociception in tegus. STUDY DESIGN: Prospective, crossover, randomized, blinded study. ANIMALS: Six healthy tegus (Salvator merianae) weighing 1.6±0.3 kg. METHODS: Tegus were administered intramuscularly saline (0.5 mL; CON), dexmedetomidine (0.2 mg kg-1 ; DX), midazolam (1 mg kg-1 ; MZ) and dexmedetomidine-midazolam (same doses; DM)...
January 17, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29543325/pharmacological-interventions-for-benzodiazepine-discontinuation-in-chronic-benzodiazepine-users
#7
REVIEW
Lone Baandrup, Bjørn H Ebdrup, Jesper Ø Rasmussen, Jane Lindschou, Christian Gluud, Birte Y Glenthøj
BACKGROUND: Prolonged treatment with benzodiazepines is common practice despite clinical recommendations of short-term use. Benzodiazepines are used by approximately 4% of the general population, with increased prevalence in psychiatric populations and the elderly. After long-term use it is often difficult to discontinue benzodiazepines due to psychological and physiological dependence. This review investigated if pharmacological interventions can facilitate benzodiazepine tapering. OBJECTIVES: To assess the benefits and harms of pharmacological interventions to facilitate discontinuation of chronic benzodiazepine use...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29530810/vascular-metabolic-and-gabaergic-inhibitory-correlates-of-neural-variability-modulation-a-combined-fmri-and-pet-study
#8
Pengmin Qin, Niall W Duncan, David Yen-Ting Chen, Chi-Jen Chen, Li-Kai Huang, Zirui Huang, Chien-Yuan E Lin, Christine Wiebking, Che-Ming Yang, Georg Northoff, Timothy Lane
Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioural states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18 F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and [18 F]-flumazenil PET in a separate group (n = 19)...
March 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29515437/polymethoxyflavones-from-nicotiana-plumbaginifolia-solanaceae-exert-antinociceptive-and-neuropharmacological-effects-in-mice
#9
Md Shafiullah Shajib, Ridwan B Rashid, Long C Ming, Shanta Islam, Md Moklesur R Sarker, Lutfun Nahar, Satyajit D Sarker, Bidyut K Datta, Mohammad A Rashid
Polymethoxylavones (PMFs) are known to exhibit significant anti-inflammatory and neuroprotective properties. Nicotiana plumbaginifolia , an annual Bangladeshi herb, is rich in polymethoxyflavones that possess significant analgesic and anxiolytic activities. The present study aimed to determine the antinociceptive and neuropharmacological activities of polyoxygenated flavonoids namely- 3,3',5,6,7,8-hexamethoxy-4',5'-methylenedioxyflavone ( 1 ), 3,3',4',5',5,6,7,8-octamethoxyflavone (exoticin) ( 2 ), 6,7,4',5'-dimethylenedioxy-3,5,3'-trimethoxyflavone ( 3 ), and 3,3',4',5,5',8-hexamethoxy-6,7-methylenedioxyflavone ( 4 ), isolated and identified from N...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29486336/the-anticonvulsant-effect-of-a-polysaccharide-rich-extract-from-genipa-americana-leaves-is-mediated-by-gaba-receptor
#10
Dayanne Terra Tenório Nonato, Silvânia Maria Mendes Vasconcelos, Mário Rogério Lima Mota, Paulo Goberlânio de Barros Silva, Arcelina Pacheco Cunha, Nágila Maria Pontes Silva Ricardo, Maria Gonçalves Pereira, Ana Maria Sampaio Assreuy, Edna Maria Camelo Chaves
BACKGROUND: This study aimed to chemically characterize a polysaccharide-rich extract (PRE) obtained from Genipa americana leaves and evaluate its neuroprotective effect in the brain morphology and oxidative markers using mice behavioral models. METHODS: Dry powder (5 g) of G. americana leaves were submitted to depigmentation in methanol. PRE was obtained by extraction in NaOH and precipitation with absolute ethanol and characterized by infrared spectroscopy (FTIR) and nuclear magnetic resonance (1 H and13 C NMR)...
February 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29480352/metabolomics-profile-in-abat-deficiency-pre-and-post-treatment
#11
Mary Kay Koenig, Penelope E Bonnen
Metabolomic profiling is an emerging technology in the clinical setting with immediate diagnostic potential for the population of patients with Inborn Errors of Metabolism. We present the metabolomics profile of two ABAT deficiency patients both pre- and posttreatment with flumazenil. ABAT deficiency, also known as GABA-transaminase deficiency, is caused by recessive mutations in the gene ABAT and leads to encephalopathy of variable severity with hypersomnolence, hypotonia, hypomyelination, and seizures. Through metabolomics screening of multiple patient tissues, we identify 2-pyrrolidinone as a biomarker for GABA that is informative in plasma, urine, and CSF...
February 27, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29468757/anxiolytic-and-antidepressant-activities-of-pelargonium-roseum-essential-oil-on-swiss-albino-mice-possible-involvement-of-serotonergic-transmission
#12
Mohaddeseh Abouhosseini Tabari, Akbar Hajizadeh Moghaddam, Filippo Maggi, Giovanni Benelli
The anxiolytic and antidepressant activities of the Reunion Geranium (Pelargonium roseum Willd) essential oil (EO) were evaluated in male Swiss albino mice by intraperitoneal administration of 10, 20, and 50 mg/kg bw using elevated plus maze (EPM), open-field test (OFT), and forced swimming test (FST). Moreover, we evaluated whether the 5-HT1A and GABAA -benzodiazepine receptor systems are involved in the anxiolytic effects through the coadministration of WAY-100635 (a selective 5-HT1A receptor antagonist) and flumazenil (an antagonist of benzodiazepine)...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29457121/anesthesia-for-patients-with-ptrf-mutations-a-case-report
#13
Atsuko Hirano, Tomohiko Takada, Mariko Senda, Hidemasa Takahashi, Takeo Suzuki
Background: Polymeraze I and transcript release factor ( PTRF ) mutations are a newly recognized disease, which cause congenital generalized lipodystrophy associated with myopathy. Case presentation: A 29-year-old man (height 126 cm; weight 22 kg) with a PTRF mutation was scheduled for mandibular dentigerous cystectomy. His primary symptoms were lipodystrophy, myopathy, long QT syndrome, refractory nephrosis, and abnormal lipid metabolism. Defibrillator pads were applied soon after the patient entered the operating room...
2018: JA Clinical Reports
https://www.readbyqxmd.com/read/29414121/sacred-maya-incense-copal-protium-copal-burseraceae-has-antianxiety-effects-in-animal-models
#14
Zul Merali, Christian Cayer, Pamela Kent, Rui Liu, Victor Cal, Cory S Harris, John T Arnason
ETHNOPHARMACOLOGICAL RELEVANCE: The Maya have traditionally used copal, Protium copal, as incense during ceremonies since pre-Columbian times. Anecdotally, copal (when burned as incense), is thought to elicit mentally uplifting and calming effects. The main objective of this study was to determine whether the incense elicits anxiolytic-like behavior in animal models using rats. A second objective was to characterize active constituents and discern potential mechanism(s) of action, specifically the involvement of the GABAergic and endocannabinoid (eCB) systems...
January 29, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29413823/automated-radiosynthesis-and-purification-of-18f-flumazenil-with-solid-phase-extraction
#15
Daria Vaulina, Morteza Nasirzadeh, Natalia Gomzina
This paper describes the novel approach for preparation of [18F]flumazenil ([18F]FMZ), well known radioligand for assessment of GABAA receptors by PET. The optimized reaction conditions allowed us to implement commercially available SPE cartridges for [18F]FMZ purification avoiding HPLC. All procedures were performed with TRACERlab FX N Pro synthesizer in 53 min. Developed approach provided [18F]FMZ with high RCP (> 97%) and low level of chemical impurities (< 5 µg/mL). FMZ was routinely synthesized in 6...
January 25, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29374303/negative-allosteric-modulation-of-alpha-5-containing-gaba-a-receptors-engenders-antidepressant-like-effects-and-selectively-prevents-age-associated-hyperactivity-in-tau-depositing-mice
#16
Nina Z Xu, Margot Ernst, Marco Treven, Rok Cerne, Mark Wakulchik, Xia Li, Timothy M Jones, Scott D Gleason, Denise Morrow, Jeffrey M Schkeryantz, Md Toufiqur Rahman, Guanguan Li, Michael M Poe, James M Cook, Jeffrey M Witkin
RATIONALE: Associated with frank neuropathology, patients with Alzheimer's disease suffer from a host of neuropsychiatric symptoms that include depression, apathy, agitation, and aggression. Negative allosteric modulators (NAMs) of α5-containing GABAA receptors have been suggested to be a novel target for antidepressant action. We hypothesized that pharmacological modulation of this target would engender increased motivation in stressful environments. METHODS: We utilized electrophysiological recordings from Xenopus oocytes and behavioral measures in mice to address this hypothesis...
April 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29372452/hibiscus-rosa-sinensis-mediate-anxiolytic-effect-via-modulation-of-ionotropic-gaba-a-receptors-possible-mechanism-of-action
#17
Zubia Begum, Ishrat Younus
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (p < 0.05) increased the number of head dips and rearings as compared to control on respective days of observation...
January 25, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29359856/efficacy-and-safety-of-flumazenil-injection-for-the-reversal-of-midazolam-sedation-after-elective-outpatient-endoscopy
#18
Sang Pyo Lee, In-Kyung Sung, Jeong Hwan Kim, Sun-Young Lee, Hyung Seok Park, Chan Sup Shim
OBJECTIVE: Midazolam sedation during elective endoscopy is widely performed and flumazenil is frequently administered after endoscopy to reverse sedation in clinical practice. This study aimed to investigate the safety and efficacy of flumazenil injections after elective endoscopy under midazolam sedation. METHODS: Participants who underwent an upper endoscopy under midazolam sedation were randomly divided into two groups. In group I, flumazenil was administered i...
February 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29297158/correction-to-parametric-imaging-of-11c-flumazenil-binding-in-the-rat-brain
#19
Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Ana Maria Marques da Silva, Michel Koole, Rudi Dierckx, Antoon Willemsen, Ronald Boellaard
The name of the second author was incorrectly cited and is corrected now, as displayed here.
April 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29286356/is-flumazenil-an-alternative-for-the-treatment-of-hepatic-encephalopathy
#20
Diego Reyes, Francisco Barrera
INTRODUCTION: Flumazenil is an antagonist of the GABA/benzodiazepines receptor complex that might play a role in the treatment of hepatic encephalopathy. However, its efficacy and safety are a matter of debate. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
December 26, 2017: Medwave
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