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https://www.readbyqxmd.com/read/27860446/a-genetic-algorithm-based-framework-for-wavelength-selection-on-sample-categorization
#1
Michel J Anzanello, Gabrielli Yamashita, Marcelo Marcelo, Flavio F Fogliatto, Rafael S Ortiz, Kristiane Mariotti, Marco F Ferrão
In forensic and pharmaceutical scenarios, the application of chemometrics and optimization techniques have unveiled common and peculiar features of seized medicine and drug samples, helping investigative forces towards tracking illegal operations. This paper proposes a novel framework aimed at identifying relevant subsets of attenuated total reflectance Fourier transform infrared (ATR-FTIR) wavelengths for classifying samples into two classes, e.g. authentic or forged categories in case of medicines, or salt or base form in cocaine analysis...
November 18, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27800121/erectile-dysfunction-drugs-changed-the-protein-expressions-and-activities-of-drug-metabolising-enzymes-in-the-liver-of-male-rats
#2
Salah A Sheweita, Mona Wally, Mostafa Hassan
Erectile dysfunction (ED) is a major health problem and is mainly associated with the persistent inability of men to maintain sufficient erection for satisfactory sexual performance. Millions of men are using sildenafil, vardenafil, and/or tadalafil for ED treatment. Cytochrome P450s (CYPs) play a central role in the metabolism of a wide range of xenobiotics as well as endogenous compounds. Susceptibility of individuals to the adverse effects of different drugs is mainly dependent on the expression of CYPs proteins...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27650039/propping-up-pharma-s-natural-neoliberal-phallic-man-pharmaceutical-representations-of-the-ideal-sexuopharmaceutical-user
#3
Maria Gurevich, Usra Leedham, Amy Brown-Bowers, Nicole Cormier, Zara Mercer
Contemporary social theorists emphasise the cultural quest for authenticity under conditions of increasing artificiality. Within this context, the body is commonly treated as an 'unfinished' surface requiring ongoing transformation to fulfil identity obligations. In this paper, we examine one such identity authentication project in the form of marketing of men's sexuopharmaceuticals. We use online pharmaceutical advertising for four approved sexuopharmaceuticals (Viagra, Cialis, STAXYN and Stendra) to describe the ideal neoliberal consumer...
September 21, 2016: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27152308/flibanserin-for-treating-hypoactive-sexual-desire-disorder
#4
REVIEW
Jae Hong Sang, Tae-Hee Kim, Soo Ah Kim
There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which have been prescribed for male sexual function disorders, are known to act on vessels.[1] On the other hand, flibanserin is thought to act on brain. Flibanserin has been approved by U. S. Food and Drug Administration (FDA) for treatment of hypoactive sexual desire disorder (HSDD) of premenopausal women in 2015, and is expected to be released in South Korea soon...
April 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/26637485/study-on-health-hazards-through-medicines-purchased-on-the-internet-a-cross-sectional-investigation-of-the-quality-of-anti-obesity-medicines-containing-crude-drugs-as-active-ingredients
#5
Naoko Yoshida, Midori Numano, Yoko Nagasaka, Kaori Ueda, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura
BACKGROUND: Weight-loss medicines, including crude drugs and herbal supplements disguised as diet-aid products, are readily obtainable and distributed widely, especially in Southeast Asia. Even if such products are unapproved or prescription-only medicines, consumers can purchase them through an agency or directly on the Internet. We evaluated the quality and safety of herbal products purchased on the Internet to reveal their influence on public health. METHODS: Diet-aid products containing Bukuryo (Poria sclerotium), Bakumondo (Ophiopogonis tuber), or Daio (rhubarb rhizome) were purchased through websites that did not provide physical addresses or which advertised misleading medicines (e...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26551887/the-cyclic-gmp-protein-kinase-g-pathway-as-a-therapeutic-target-in-head-and-neck-squamous-cell-carcinoma
#6
Traci R Tuttle, Michelle L Mierzwa, Susanne I Wells, Sejal R Fox, Nira Ben-Jonathan
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with high mortality. Treatments, which can result in significant morbidity, have not substantially changed in three decades. The second messenger cyclic GMP (cGMP), which targets protein kinase G (PKG), is generated by guanylate cyclases (GCs), and is rapidly hydrolyzed by phosphodiesterases (PDEs). Activation of the cGMP/PKG pathway is antineoplastic in several cancer types, but its impact on HNSCC has not been fully exploited. We found differential expression of critical components of this pathway in four HNSCC cell lines...
January 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/26033891/physical-profiling-and-ir-spectroscopy-simple-and-effective-methods-to-discriminate-between-genuine-and-counterfeit-samples-of-viagra%C3%A2-and-cialis%C3%A2
#7
Deborah Custers, Suzanne Vandemoortele, Jean-Luc Bothy, Jacques O De Beer, Patricia Courselle, Sandra Apers, Eric Deconinck
Counterfeit medicines are a global threat to public health. High amounts enter the European market, enforcing the need for simple techniques to help customs detect these pharmaceuticals. This study focused on physical profiling and IR spectroscopy to obtain a prime discrimination between genuine and illegal Viagra® and Cialis® medicines. Five post-tableting characteristics were explored: colour, mass, long length, short length, and thickness. Hypothesis testing showed that most illegal samples (between 60 and 100%) significantly differ from the genuine medicines, in particular for mass and long length...
March 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/25843350/a-synthetic-cgmp-sensitive-gene-switch-providing-viagra-%C3%A2-controlled-gene-expression-in-mammalian-cells-and-mice
#8
Taeuk Kim, Marc Folcher, Ghislaine Charpin-El Hamri, Martin Fussenegger
Cyclic guanosine monophosphate (cGMP) is a universal second messenger that is synthesized from guanosine triphosphate (GTP) by guanylyl cyclases (GCs) and hydrolyzed into guanosine monophosphate (GMP) by phosphodiesterases (PDEs). Small-molecule drugs that induce high cGMP levels in specialized tissues by boosting GC activity or inhibiting PDE activity have become the predominant treatment strategy for a wide range of medical conditions, including congestive heart failure, pulmonary hypertension, atherosclerosis-based claudication and erectile dysfunction...
May 2015: Metabolic Engineering
https://www.readbyqxmd.com/read/25768099/interventions-to-treat-premature-ejaculation-a-systematic-review-short-report
#9
REVIEW
Katy Cooper, Marrissa Martyn-St James, Eva Kaltenthaler, Kath Dickinson, Anna Cantrell
BACKGROUND: Premature ejaculation (PE) is commonly defined as ejaculation with minimal sexual stimulation before, on or shortly after penetration and before the person wishes it. PE can be either lifelong and present since first sexual experiences (primary), or acquired (secondary), beginning later (Godpodinoff ML. Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther 1989;15:130-4). Treatments include behavioural and pharmacological interventions. OBJECTIVE: To systematically review evidence for clinical effectiveness of behavioural, topical and systemic treatments for PE...
March 2015: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/25689303/hspa5-dna-k-may-be-a-useful-target-for-human-disease-therapies
#10
Laurence Booth, Jane L Roberts, Paul Dent
The chaperone protein HSPA5/Dna K is conserved throughout evolution from higher eukaryotes down to prokaryotes. The celecoxib derivative OSU-03012 (also called AR-12) interacts with Viagra or Cialis in eukaryotic cells to rapidly reduce HSPA5 levels as well as blunt the functions of many other chaperone proteins. Because multiple chaperones are modulated in eukaryotes, the expression of cell surface virus receptors is reduced and because HSPA5 in blocked viruses cannot efficiently replicate. Because DnaK levels are reduced in prokaryotes by OSU-03012, the levels of DnaK chaperone proteins such as Rec A decline, which is associated with bacterial cell death and a resensitization of so-called drug-resistant superbugs to standard of care antibiotics...
March 2015: DNA and Cell Biology
https://www.readbyqxmd.com/read/25546329/grp78-bip-hspa5-dna-k-is-a-universal-therapeutic-target-for-human-disease
#11
Laurence Booth, Jane L Roberts, Devin R Cash, Seyedmehrad Tavallai, Sophonie Jean, Abigail Fidanza, Tanya Cruz-Luna, Paul Siembiba, Kelly A Cycon, Cynthia N Cornelissen, Paul Dent
The chaperone GRP78/Dna K is conserved throughout evolution down to prokaryotes. The GRP78 inhibitor OSU-03012 (AR-12) interacted with sildenafil (Viagra) or tadalafil (Cialis) to rapidly reduce GRP78 levels in eukaryotes and as a single agent reduce Dna K levels in prokaryotes. Similar data with the drug combination were obtained for: HSP70, HSP90, GRP94, GRP58, HSP27, HSP40 and HSP60. OSU-03012/sildenafil treatment killed brain cancer stem cells and decreased the expression of: NPC1 and TIM1; LAMP1; and NTCP1, receptors for Ebola/Marburg/Hepatitis A, Lassa fever, and Hepatitis B viruses, respectively...
July 2015: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/25505249/the-unexpected-evolution-of-basic-science-studies-about-cyclic-nucleotide-action-into-a-treatment-for-erectile-dysfunction
#12
Jackie Corbin
In these Reflections, I describe my perceived role in discoveries made in the cyclic nucleotide field that culminated in the advent of PDE5 inhibitors that treat erectile dysfunction, such as Viagra, Levitra, and Cialis. The discoveries emphasize the critical role of basic science, which often evolves in unpredictable and circuitous paths, in improving human health.
January 16, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25444755/pde5-inhibitors-as-therapeutics-for-heart-disease-diabetes-and-cancer
#13
REVIEW
Anindita Das, David Durrant, Fadi N Salloum, Lei Xi, Rakesh C Kukreja
The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™), vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile dysfunction. Moreover, sildenafil and tadalafil are used for the management of pulmonary arterial hypertension in patients. Since our first report showing the cardioprotective effect of sildenafil in 2002, there has been tremendous growth of preclinical and clinical studies on the use of PDE5 inhibitors for cardiovascular diseases and cancer...
March 2015: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25390923/intracoital-subfoveal-hemorrhage-after-tadalafil-cialis-premedication-a-case-report
#14
Tommaso Rossi, Barbara Boccassini, Luca Placentino, Mario Iossa, Maria Giulia Mutolo, Ciro Tamburrelli
PURPOSE: The purpose of this study is to report the first case, to our knowledge, of intracoital subfoveal hemorrhage occurring 1 hour after tadalafil premedication in a patient with previously undiagnosed retinal angiomatous proliferation and erectile dysfunction. METHODS: This is an interventional case report. The patient underwent Snellen vision acuity measurement, anterior and posterior segment biomicroscopy, and indirect ophthalmoscopy. Optical coherence tomography, fluorescein angiography, and indocyanine green angiography were also performed as needed...
2010: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/25278199/selecting-relevant-fourier-transform-infrared-spectroscopy-wavenumbers-for-clustering-authentic-and-counterfeit-drug-samples
#15
Michel J Anzanello, Flavio S Fogliatto, Rafael S Ortiz, Renata Limberger, Kristiane Mariotti
This paper proposes a novel method for selecting subsets of wavenumbers provided by attenuated total reflectance by Fourier transform infrared (ATR-FTIR) spectroscopy able to improve the clustering of medicine samples into two groups; i.e., authentic or fraudulent. For that matter, we apply principal components analysis (PCA) to ATR-FTIR data, and derive two variable importance indices from the PCA parameters. Next, an iterative variable (i.e. wavenumbers) elimination procedure and sample clustering through k-means and Fuzzy C-means techniques are carried out; clustering performance is assessed by the Silhouette Index (SI)...
September 2014: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/25202655/can-selective-inhibitors-of-cyclic-guanosine-monophosphate-cgmp-specific-phosphadiesterase-type-5-pde-5-offer-protection-against-contrast-induced-nephropathy
#16
Sameh K Morcos
Parenchymal hypoxia within the renal outer medulla plays an important role in the pathogenesis of contrast induced nephropathy (CIN). Nitric oxide (NO) is crucial for medullary oxygenation by enhancing regional blood flow. Augmenting the effect of NO in the renal medulla by the use of selective inhibitors of cyclic guanosine monophosphate (cGMP)-specific phosphadiesterase type 5 (PDE 5) such as sildenafil (Viagra™), vardenafil (Levitra™) or tadalafil (Cialis™) could reduce the severity of the hypoxic insult induced by the contrast medium and reduce the risk of CIN...
August 2014: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/25193174/interactions-of-non-charged-tadalafil-stereoisomers-with-cyclodextrins-capillary-electrophoresis-and-nuclear-magnetic-resonance-studies
#17
Ida Fejős, Adrienn Kazsoki, Tamás Sohajda, Ede Márványos, Balázs Volk, Lajos Szente, Szabolcs Béni
The single isomer drug R,R-tadalafil (Cialis) contains two chiral centers thus four stereoisomers (R,R-, S,S-, S,R- and R,S-tadalafil) exist, however, only the most potent inhibitor, the R,R-tadalafil is in clinical use. In our study, over 20 charged cyclodextrin (CD) derivatives were studied for enantiospecific host-guest type interactions in CD-modified capillary electrophoresis. Tadalafil stereoisomers are non-charged; therefore, their electrophoretic separation poses a challenge. Several candidates of both positively and negatively charged hosts were found to be effective for the enantioseparation...
October 10, 2014: Journal of Chromatography. A
https://www.readbyqxmd.com/read/25047218/pls-da-wavenumber-selection-for-the-categorization-of-medicine-samples-based-on-multiple-criteria
#18
Michel J Anzanello, Rafael S Ortiz, Renata Limberger, Kristiane Mariotti
ATR-FTIR spectra may include a large number of noisy and correlated wavenumbers that tend to affect and reduce the performance of exploratory and classificatory multivariate techniques. We propose a method based on Partial Least Square Discriminant Analysis (PLS-DA) for identifying the relevant subsets of ATR-FTIR wavenumbers aimed at classifying Viagra and Cialis into authentic or fraudulent categories. In our propositions, the PLS-DA is applied to ATR-FTIR data, and four indices aimed at evaluating wavenumber importance are derived from PLS-DA parameters...
September 2014: Forensic Science International
https://www.readbyqxmd.com/read/24725867/headspace-gas-chromatographic-fingerprints-to-discriminate-and-classify-counterfeit-medicines
#19
D Custers, M Canfyn, P Courselle, J O De Beer, S Apers, E Deconinck
Counterfeit medicines are a global threat to public health. These pharmaceuticals are not subjected to quality control and therefore their safety, quality and efficacy cannot be guaranteed. Today, the safety evaluation of counterfeit medicines is mainly based on the identification and quantification of the active substances present. However, the analysis of potential toxic secondary components, like residual solvents, becomes more important. Assessment of residual solvent content and chemometric analysis of fingerprints might be useful in the discrimination between genuine and counterfeit pharmaceuticals...
June 2014: Talanta
https://www.readbyqxmd.com/read/24447444/a-framework-for-selecting-analytical-techniques-in-profiling-authentic-and-counterfeit-viagra-and-cialis
#20
Michel J Anzanello, Rafael S Ortiz, Renata Limberger, Kristiane Mariotti
Several analytical techniques aimed at profiling drugs are deemed costly and time consuming, and may not be promptly available for analysis when required. This paper proposes a method for identifying the analytical techniques providing the most relevant data for classification of drug samples into authentic and unauthentic categories. For that matter, we integrate principal components analysis (PCA) to k-Nearest Neighbor (KNN) and Support Vector Machine (SVM) classification tools. PCA is first applied to data from five techniques, i...
February 2014: Forensic Science International
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