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https://www.readbyqxmd.com/read/27917837/purification-crystallization-and-characterization-of-the-pseudomonas-outer-membrane-protein-fapf-a-functional-amyloid-transporter
#1
Sarah L Rouse, Wlliam J Hawthorne, Sebastian Lambert, Marc L Morgan, Stephen A Hare, Stephen Matthews
Bacteria often produce extracellular amyloid fibres via a multi-component secretion system. Aggregation-prone, unstructured subunits cross the periplasm and are secreted through the outer membrane, after which they self-assemble. Here, significant progress is presented towards solving the high-resolution crystal structure of the novel amyloid transporter FapF from Pseudomonas, which facilitates the secretion of the amyloid-forming polypeptide FapC across the bacterial outer membrane. This represents the first step towards obtaining structural insight into the products of the Pseudomonas fap operon...
December 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27913673/structural-insights-into-functional-amyloid-inhibition-in-gram-ve-bacteria
#2
REVIEW
William Hawthorne, Sarah Rouse, Lee Sewell, Stephen J Matthews
Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid...
December 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27884330/factors-associated-with-adverse-events-after-emergency-laparotomy-in-cape-town-south-africa-identifying-opportunities-for-quality-improvement
#3
Richard Trafford Spence, Mark Hampton, Kent Pluke, Miriam Kahn, Nkhabe Chinyepi, Mohamed Elmusbahi, Tirsa van Wyngaard, Eugenio Panieri
BACKGROUND: Surgical outcomes research is limited in areas of the world with the greatest unmet surgical need and likely greatest variation in outcomes. Measurement alone may improve outcomes-the so-called Hawthorne effect. The purpose of this multicenter cohort study was to identify factors that are both feasible to collect and are associated with a major adverse event following a targeted procedure in Cape Town, South Africa. METHODS: A collaborative of four acute care surgical units was formed to develop a data set with minimal data burden describing outcomes after an emergency exploratory laparotomy during a 3-mo period (February-April 2015)...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27878303/neuroprotective-effects-of-vitexin-against-isoflurane-induced-neurotoxicity-by-targeting-the-trpv1-and-nr2b-signaling-pathways
#4
Linlin Chen, Bin Zhang, Shiqiang Shan, Xin Zhao
Vitexin is a bioactive compound extracted from hawthorn leaves, which reduces blood pressure and has anti‑inflammatory and potential anticancer effects. However, the mechanisms underlying the protective effects of vitexin against isoflurane‑induced neurotoxicity remain elusive. Therefore, the aim of the present study was to investigate these mechanisms further. Sprague Dawley rats received 1.4% isoflurane in a 100% oxygen environment for 2 h. Human PC12 pheochromocytoma neurosecretory cells were exposed to 2% isoflurane for 12 h before they were treated with 1, 10 or 100 µM vitexin for a further 24 h...
November 16, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27855899/phenolic-compounds-extracted-by-acidic-aqueous-ethanol-from-berries-and-leaves-of-different-berry-plants
#5
Ye Tian, Jaana Liimatainen, Aino-Liisa Alanne, Anni Lindstedt, Pengzhan Liu, Jari Sinkkonen, Heikki Kallio, Baoru Yang
Phenolic compounds of berries and leaves of thirteen various plant species were extracted with aqueous ethanol and analyzed with UPLC-DAD-ESI-MS, HPLC-DAD, and NMR. The total content of phenolics was consistently higher in leaves than in berries (25-7856 vs. 28-711mg/100g fresh weight). Sea buckthorn leaves were richest in phenolic compounds (7856mg/100g f.w.) with ellagitannins as the dominant compound class. Sea buckthorn berries contained mostly isorhamnetin glycosides, whereas quercetin glycosides were typically abundant in most samples investigated...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27852126/traditional-chinese-medicine-food-therapy-and-hypertension-control-a-narrative-review-of-chinese-literature
#6
Ping Zou
Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27851213/1578-public-perception-of-the-use-of-critical-care-patient-data-beyond-treatment-a-pilot-study
#7
John Kinsella, Martin Shaw, Christopher Hawthorne, Ian Piper, Richard Elliott, Christine Lee, Laura Moss
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850399/761-improvements-to-the-optimal-cerebral-perfusion-pressure-calculation
#8
Christopher Hawthorne, Martin Shaw, Laura Moss, Ian Piper, Richard Elliott, Christine Lee, John Kinsella
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847959/novel-time-temperature-and-consume-within-indicator-based-on-gas-diffusion
#9
A Mills, D Hawthorne, A Graham, K Lawrie
The novel time-temperature indicator label comprises an ammonia sensitive indicator layer film pressed onto a second film, comprising an ammonia-generating, adhesive layer. When separated the blue-coloured indicator film reverts back to its original (ammonia free) yellow form at a controllable, temperature dependant rate. The labels are easily made and stored.
November 16, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27820783/reply-to-comment-on-the-article-dcd-pancreas-transplantation-meta-analysis-ethical-and-technical-considerations
#10
Sara Shahrestani, Paul Robertson, Henry Pleass, Wayne J Hawthorne
No abstract text is available yet for this article.
November 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27812110/assessing-the-claims-of-participatory-measurement-reporting-and-verification-pmrv-in-achieving-redd-outcomes-a-systematic-review
#11
Sandra Hawthorne, Manuel Boissière, Mary Elizabeth Felker, Stibniati Atmadja
Participation of local communities in the Measurement, Reporting and Verification (MRV) of forest changes has been promoted as a strategy that lowers the cost of MRV and increases their engagement with REDD+. This systematic review of literature assessed the claims of participatory MRV (PMRV) in achieving REDD+ outcomes. We identified 29 PMRV publications that consisted of 20 peer-reviewed and 9 non peer-reviewed publications, with 14 publications being empirically based studies. The evidence supporting PMRV claims was categorized into empirical finding, citation or assumption...
2016: PloS One
https://www.readbyqxmd.com/read/27790234/transcriptome-analysis-and-ultrastructure-observation-reveal-that-hawthorn-fruit-softening-is-due-to-cellulose-hemicellulose-degradation
#12
Jiayu Xu, Yuhui Zhao, Xiao Zhang, Lijie Zhang, Yali Hou, Wenxuan Dong
Softening, a common phenomenon in many fruits, is a well coordinated and genetically determined process. However, the process of flesh softening during ripening has rarely been described in hawthorn. In this study, we found that 'Ruanrou Shanlihong 3 Hao' fruits became softer during ripening, whereas 'Qiu JinXing' fruits remained hard. At late developmental stages, the firmness of 'Ruanrou Shanlihong 3 Hao' fruits rapidly declined, and that of 'Qiu JinXing' fruits remained essentially unchanged. According to transmission electron microscopy, the middle lamella of 'Qiu JinXing' and 'Ruanrou Shanlihong 3 Hao' fruit flesh was largely degraded as the fruits matured...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27777730/evidence-for-ecological-speciation-via-a-host-shift-in-the-holly-leaf-miner-phytomyza-glabricola-diptera-agromyzidae
#13
Julie B Hébert, Sonja J Scheffer, David J Hawthorne
Evolutionary radiations have been well documented in plants and insects, and natural selection may often underly these radiations. If radiations are adaptive, the diversity of species could be due to ecological speciation in these lineages. Agromyzid flies exhibit patterns of repeated host-associated radiations. We investigated whether host-associated population divergence and evidence of divergent selection exist in the leaf miner Phytomyza glabricola on its sympatric host plants, the holly species, Ilex coriacea and I...
September 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27776376/single-laboratory-validation-for-the-determination-of-flavonoids-in-hawthorn-leaves-and-finished-products-by-lc-uv
#14
Elizabeth M Mudge, Ying Liu, Jensen A Lund, Paula N Brown
Suitably validated analytical methods that can be used to quantify medicinally active phytochemicals in natural health products are required by regulators, manufacturers, and consumers. Hawthorn (Crataegus) is a botanical ingredient in natural health products used for the treatment of cardiovascular disorders. A method for the quantitation of vitexin-2″-O- rhamnoside, vitexin, isovitexin, rutin, and hyperoside in hawthorn leaf and flower raw materials and finished products was optimized and validated according to AOAC International guidelines...
November 2016: Planta Medica
https://www.readbyqxmd.com/read/27765508/antioxidant-and-anti-inflammatory-neolignans-from-the-seeds-of-hawthorn
#15
Ying Peng, Li-Li Lou, Si-Fan Liu, Le Zhou, Xiao-Xiao Huang, Shao-Jiang Song
Seven new neolignans (1-2, 7-11) and five known compounds (3-6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7-12 exhibited marked nitric oxide (NO) inhibition and compounds 1-4 had a potent necrosis factor-α (TNF-α) inhibitory effect...
October 7, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27749583/maximizing-kidneys-for-transplantation-using-machine-perfusion-from-the-past-to-the-future-a-comprehensive-systematic-review-and-meta-analysis
#16
Ahmer M Hameed, Henry C Pleass, Germaine Wong, Wayne J Hawthorne
BACKGROUND: The two main options for renal allograft preservation are static cold storage (CS) and machine perfusion (MP). There has been considerably increased interest in MP preservation of kidneys, however conflicting evidence regarding its efficacy and associated costs have impacted its scale of clinical uptake. Additionally, there is no clear consensus regarding oxygenation, and hypo- or normothermia, in conjunction with MP, and its mechanisms of action are also debated. The primary aims of this article were to elucidate the benefits of MP preservation with and without oxygenation, and/or under normothermic conditions, when compared with CS prior to deceased donor kidney transplantation...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27748195/adonis-sp-convallaria-sp-strophanthus-sp-thevetia-sp-and-leonurus-sp-cardiotonic-plants-with-known-traditional-use-and-a-few-preclinical-and-clinical-studies
#17
Ilkay Erdogan Orhan, Alper Gokbulut, F Sezer Senol
Plants have been always a fruitful source of active metabolites against many human disorders, where cardiovascular (CV) diseases have been one of the major health problems all over the world. There are some clinically proved medicinal plants with cardioprotective effects such as Crataegus monogyna and C. oxyacantha (hawthorn) from Rosaceae. On the other hand, cardiac glycosides, present in a number of plant species, are well-known for their cardiotonic activity. However, we encountered such a fact that very less number of studies are available on the source plants; e...
October 10, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27716866/-is-drg-coding-too-important-to-be-left-to-physicians-evaluation-of-economic-efficiency-by-health-economists-in-a-university-medical-centre
#18
F Burger, M Walgenbach, P Göbel, S Parbs, E Neugebauer
Background: We investigated and evaluated the cost effectiveness of coding by health care economists in a centre for orthopaedics and trauma surgery in Germany, by quantifying and comparing the financial efficiency of physicians with basic knowledge of the DRG-system with the results of healthcare economists with in-depth knowledge (M.Sc.). In addition, a hospital survey was performed to establish how DRG-coding is being performed and the identity of the persons involved. Material and Methods: In a prospective and controlled study, 200 in-patients were coded by a healthcare economist (study group)...
October 7, 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27706748/classification-and-phylogenetic-analysis-of-chinese-hawthorn-assessed-by-plant-and-pollen-morphology
#19
S L Y Ma, Y M Lu
The Chinese hawthorn (Crataegus pinnatifida Bge. var. major N.E.Br.) is uniquely originated in northern China. The ecological and horticultural importance of Chinese hawthorn is considerable and some varieties are valued for their fruit or medicine extracts. Its taxonomy and phylogeny remain poorly understood. Apart from general plant morphological traits, pollen is an important trait for the classification of plants and their evolutionary origin. However, few studies have investigated the pollen of Chinese hawthorn...
September 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27703751/the-long-term-mental-health-impact-of-peacekeeping-prevalence-and-predictors-of-psychiatric-disorder
#20
David Forbes, Meaghan O'Donnell, Rachel M Brand, Sam Korn, Mark Creamer, Alexander C McFarlane, Malcolm R Sim, Andrew B Forbes, Graeme Hawthorne
BACKGROUND: The mental health outcomes of military personnel deployed on peacekeeping missions have been relatively neglected in the military mental health literature. AIMS: To assess the mental health impacts of peacekeeping deployments. METHOD: In total, 1025 Australian peacekeepers were assessed for current and lifetime psychiatric diagnoses, service history and exposure to potentially traumatic events (PTEs). A matched Australian community sample was used as a comparator...
January 2016: BJPsych Open
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