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https://www.readbyqxmd.com/read/29735550/microrna-339-promotes-development-of-stem-cell-leukemia-lymphoma-syndrome-via-downregulation-of-the-bcl2l11-and-bax-pro-apoptotic-genes
#1
Tianxiang Hu, Yating Chong, Sumin Lu, Rebecca Wang, Haiyan Qin, Jeane Silva, Eiko Kitamura, Chang-Sheng Chang, LesleyAnn Hawthorn, John K Cowell
Development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apoptosis. These phenotypes are related to the stem cell leukemia/lymphoma syndrome (SCLL), which arises through the effects of activated FGFR1 kinase on gene transcription, including dysregulation of microRNAs. In a screen for miRNAs that are directly regulated by FGFR1 and that stimulate cell proliferation and survival, we identified miR-339-5p, which is highly upregulated in cells carrying various different chimeric kinases...
May 7, 2018: Cancer Research
https://www.readbyqxmd.com/read/29720209/cluster-randomised-controlled-trial-of-a-theory-based-multiple-behaviour-change-intervention-aimed-at-healthcare-professionals-to-improve-their-management-of-type-2-diabetes-in-primary-care
#2
Justin Presseau, Joan Mackintosh, Gillian Hawthorne, Jill J Francis, Marie Johnston, Jeremy M Grimshaw, Nick Steen, Tom Coulthard, Heather Brown, Eileen Kaner, Marko Elovainio, Falko F Sniehotta
BACKGROUND: National diabetes audits in the UK show room for improvement in the quality of care delivered to people with type 2 diabetes in primary care. Systematic reviews of quality improvement interventions show that such approaches can be effective but there is wide variability between trials and little understanding concerning what explains this variability. A national cohort study of primary care across 99 UK practices identified modifiable predictors of healthcare professionals' prescribing, advising and foot examination...
May 2, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29690570/mapping-the-hidden-hazards-community-led-spatial-data-collection-of-street-level-environmental-stressors-in-a-degraded-urban-watershed
#3
Na'Taki Osborne Jelks, Timothy L Hawthorne, Dajun Dai, Christina H Fuller, Christine Stauber
We utilized a participatory mapping approach to collect point locations, photographs, and descriptive data about select built environment stressors identified and prioritized by community residents living in the Proctor Creek Watershed, a degraded, urban watershed in Northwest Atlanta, Georgia. Residents (watershed researchers) used an indicator identification framework to select three watershed stressors that influence urban livability: standing water, illegal dumping on land and in surface water, and faulty stormwater infrastructure...
April 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29672935/electrocardiographic-effects-of-hawthorn-crataegus-oxyacantha-in-healthy-volunteers-a-randomized-controlled-trial
#4
Stephanie E Trexler, Elaine Nguyen, Samantha M Gromek, Marcy J Balunas, William L Baker
The objective of this study was to evaluate the electrocardiographic effects of hawthorn in healthy adult volunteers. It was double-blind cross-over trial randomized 20 healthy adult volunteers to receive either a single oral 160-mg dose of hawthorn or matching placebo. Triplicate 12-lead electrocardiograms were taken before treatment and at 1-, 2-, 4-, and 6-hr post-dose. Following at least a 7-day washout period, participants were crossed over to the opposing treatment arm and had the measurements repeated...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29660753/crataegus-special-extract-ws-1442-effects-on-enos-and-microrna-155
#5
Xinwen Wang, Yan Liang, Jian Shi, Hao-Jie Zhu, Barry E Bleske
Increased expression of microRNA 155 (miR-155) results in a decrease in endothelial nitric oxide synthase (eNOS) expression and impaired endothelial function. Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers ( Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids. The purpose of this study is to determine the effect of WS 1442 on the expression of miR-155 and eNOS in the presence of tumor necrosis factor (TNF- α )...
April 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29655927/interruptions-experienced-by-emergency-nurses-implications-for-subjective-and-objective-measures-of-workload
#6
Katherine L Forsyth, Hunter J Hawthorne, Nibras El-Sherif, Rachelen S Varghese, Vickie K Ernste, Jordyn Koenig, Renaldo C Blocker
INTRODUCTION: This study aimed to describe interruptions experienced by emergency nurses and establish convergence validity of 1 objective workload measure by linking interruption characteristics to objective and subjective measures of workload. METHODS: Interruptions were captured in real time across 8- or 12-hour shifts using a previously validated Workflow Interruptions Tool (WIT). Data collected on each interruption included type, priority, and location where the interruption occurred...
April 11, 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#7
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655581/paternal-understanding-of-menstrual-concerns-in-young-women
#8
Jane E Girling, Samuel Cj Hawthorne, Jennifer L Marino, Abdul G Nur Azurah, Sonia R Grover, Yasmin L Jayasinghe
STUDY OBJECTIVE: No studies have specifically considered paternal understanding of menstruation. This study aimed to establish the degree of understanding of fathers of adolescent girls with menstrual symptoms relative to mothers. DESIGN AND SETTING: This is a cross-sectional survey-based study. Adolescent patients attending an outpatient gynaecology clinic for dysmenorrhoea and/or heavy menstrual bleeding (HMB) and their parents were invited to complete surveys...
April 12, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29644566/effects-of-enzyme-supplementation-on-the-nutrient-amino-acid-and-energy-utilization-efficiency-of-citrus-pulp-and-hawthorn-pulp-in-linwu-ducks
#9
Xu Zhang, Haobang Li, Guitao Jiang, Xiangrong Wang, Xuan Huang, Chuang Li, Duanqin Wu, Qiuzhong Dai
The objective of this study was to evaluate the effects of enzyme supplementation on the nutrient, amino acid, and energy utilization efficiency of citrus pulp and hawthorn pulp as unusual feedstuffs in Linwu ducks. Forty ducks were assigned to each treatment group and fed diets with or without complex enzyme supplementation. All birds received the same quantity of raw material (60 g) via the force-feeding procedure. With the exception of leucine and phenylalanine, amino acid concentrations in hawthorn pulp were twice those in citrus pulp...
April 11, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29630157/an-intensely-pruritic-pebbled-presentation
#10
Livia Francine Soriano, Conn McGrath, Mark Hawthorne, Arucha Linda Ekeowa-Anderson
Lichen amyloidosis (LA) is a form of primary localized cutaneous amyloidosis (PLCA) characterized by bilateral intensely itchy domed scaly hyperkeratotic papules. Lichen amyloidosis is rare and affects men more than women. It is uncommonly seen in the western world but more prevalent in Asia. These papules most typically affect the shins and occasionally the arms and torso. Lichen amyloidosis has been reported in association with autoimmune disorders and after prolonged exfoliation and friction of affected skin...
March 7, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29604674/the-effect-of-sentential-context-on-phonetic-categorization-is-modulated-by-talker-accent-and-exposure
#11
Jessamyn Schertz, Kara Hawthorne
Higher-level factors, including the contextual plausibility of competing word candidates, interact with lower-level phonetic cues to influence how listeners interpret the speech signal. This work shows that listeners' phonetic categorization (e.g., coat versus goat) is more heavily influenced by sentential context when listening to a non-native versus native talker. Further, the effect of context on phonetic categorization decreases as the listener becomes familiar with the talker's phonetic characteristics, for both native and non-native talkers...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29593243/author-correction-the-contribution-of-predators-and-scavengers-to-human-well-being
#12
Christopher J O'Bryan, Alexander R Braczkowski, Hawthorne L Beyer, Neil H Carter, James E M Watson, Eve McDonald-Madden
In the version of this Review originally published, there were a number of errors that the authors wish to correct.
March 28, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29588834/practical-guidance-on-the-use-of-faecal-calprotectin
#13
REVIEW
Matthew J Brookes, Simon Whitehead, Daniel R Gaya, Antony Barney Hawthorne
Differentiation between inflammatory bowel disease (IBD) and functional gut disorders, and the determination of mucosal disease activity in established cases of IBD remain the cornerstones of disease diagnosis and management. Non-invasive, accurate biomarkers of gut inflammation are needed due to the variability of symptoms, the inaccuracies of currently available blood markers and the cost and invasive nature of endoscopy. Numerous biomarkers have been used and/or considered with some in current use. This article reviews the current evidence base around the indications for using biomarkers and their limitations, with a particular focus on faecal calprotectin...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29584464/endophyte-enhanced-phytoremediation-of-dde-contaminated-using-cucurbita-pepo-a-field-trial
#14
N Eevers, J R Hawthorne, J C White, J Vangronsveld, N Weyens
Although the use of the pesticide 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) was banned from the mid-1970s, its most abundant and recalcitrant degradation product, 2,2-bis(p-chlorophenyl)-1,1-dichloro-ethylene (DDE), is still present in terrestrial and aquatic ecosystems worldwide. Zucchini (Cucurbita pepo ssp. pepo) has been shown to accumulate high concentrations of DDE and was proposed for phytoremediation of contaminated soils. We performed a field trial covering a full plant life cycle. C. pepo plants inoculated with the plant growth-promoting endophytic strains Sphingomonas taxi UH1, Methylobacterium radiotolerans UH1, Enterobacter aerogenes UH1, or a consortium combining these 3 strains were grown on a DDE-contaminated field for 100 days...
March 21, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29580743/surgical-trends-in-arthroscopic-hip-surgery-using-a-large-national-database
#15
Nicholas A Bonazza, Brittany Homcha, Guodong Liu, Douglas L Leslie, Aman Dhawan
PURPOSE: To assess the practice trends in hip arthroscopy, including femoroplasty, acetabuloplasty, and labral repair Current Procedure Terminology, 4th edition (CPT-4), codes that have been implemented since many of the previous studies were published, without concerns for Hawthorne or observer effect as can be seen during a board collection window, and in a larger volume of patients with a more comprehensive database than previous published data. METHODS: The MarketScan Commercial Claims and Encounters database was searched using CPT-4 codes to identify patients who underwent any arthroscopic hip procedure from 2008 to 2013...
March 23, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29528739/medical-schools-must-prepare-students-for-leadership
#16
Christopher Holland, Kamila Hawthorne
No abstract text is available yet for this article.
March 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29496171/resveratrol-combined-with-total-flavones-of-hawthorn-alleviate-the-endothelial-cells-injury-after-coronary-bypass-graft-surgery
#17
Ying Zhu, Bing Feng, Songmin He, Zuqing Su, Guangjuan Zheng
OBJECTIVE: To explore the preventive and therapeutic effects of Resveratrol combined with total flavones of hawthorn, compatibility of traditional Chinese medicines, on the endothelial cells injury after artery bypass graft surgery. METHODS: The animal model of coronary artery bypass grafting (CABG) was prepared by transplanting a segment of autologous jugular vein onto the transected common carotid artery in rabbits. After CABG surgery, the rabbits were administrated with saline (model group), aspirin (Aspirin group), resveratrol (Res group), total flavones of hawthorn (Haw group) and resveratrol combined with total flavones of hawthorn (Res+Haw group) once a day for eight weeks, respectively...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29494232/cationic-lipid-bioanalysis-understanding-distribution-of-lipid-nanoparticles-for-delivery-of-rna-therapeutics
#18
Glen Hawthorne, Sarah Harbach, Amanda Wilson
No abstract text is available yet for this article.
March 1, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29492562/investigation-of-the-relationship-between-the-burden-of-raised-icp-and-the-length-of-stay-in-a-neuro-intensive-care-unit
#19
Martin Shaw, Laura Moss, Chris Hawthorne, John Kinsella, Ian Piper
OBJECTIVES: Raised intracranial pressure (ICP) is well known to be indicative of a poor outcome in traumatic brain injury (TBI). This phenomenon was quantified using a pressure time index (PTI) model of raised ICP burden in a paediatric population. Using the PTI methodology, this pilot study is aimed at investigating the relationship between raised ICP and length of stay (LOS) in adults admitted to a neurological intensive care unit (neuro-ICU). MATERIALS AND METHODS: In 10 patients admitted to the neuro-ICU following TBI, ICP was measured and data from the first 24 h were analysed...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492558/medical-waveform-format-encoding-rules-representation-of-neurointensive-care-waveform-data
#20
Ian Piper, Martin Shaw, Christopher Hawthorne, John Kinsella, Laura Moss
OBJECTIVE: Technology in neurointensive care units can collect and store vast amounts of complex patient data. The CHART-ADAPT project is aimed at developing technology that will allow for the collection, analysis and use of these big data at the patient's bedside in neurointensive care units. A requirement of this project is to automatically extract and transfer high-frequency waveform data (e.g. ICP) from monitoring equipment to high performance computing infrastructure for analysis...
2018: Acta Neurochirurgica. Supplement
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