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https://www.readbyqxmd.com/read/28535421/differentiation-of-crataegus-spp-guided-by-nuclear-magnetic-resonance-spectrometry-with-chemometric-analyses
#1
Jensen A Lund, Paula N Brown, Paul R Shipley
For compliance with US Current Good Manufacturing Practice regulations for dietary supplements, manufacturers must provide identity of source plant material. Despite the popularity of hawthorn as a dietary supplement, relatively little is known about the comparative phytochemistry of different hawthorn species, and in particular North American hawthorns. The combination of NMR spectrometry with chemometric analyses offers an innovative approach to differentiating hawthorn species and exploring the phytochemistry...
May 20, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28533575/antihypertensive-effects-of-hydroalcoholic-extract-of-crataegus-azarolus-subspecies-aronia-fruit-in-rats-with-renovascular-hypertension-an-experimental-mechanistic-study
#2
Mohammad Reza Haydari, Mohammad Reza Panjeshahin, Elaheh Mashghoolozekr, Ali Akbar Nekooeian
BACKGROUND: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. METHODS: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of one sham group and 5 renal artery-clipped groups. The sham group received vehicle (distilled water 0...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28503940/matrix-solid-phase-dispersion-as-a-tool-for-phytochemical-and-bioactivities-characterisation-crataegus-oxyacantha-l-_a-case-study
#3
Wassila Benabderrahmane, Marta Lores, Juan Pablo Lamas, Samir Benayache
The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic profile is solvent dependent. The extracts were analysed by HPLC-DAD for the accurate identification of the major bioactive polyphenols, some of which have never been described for this species. MSPD has proven to be a good alternative to the classic methods of obtaining natural extracts, fast and with low consumption of organic solvents, therefore, environmentally friendly...
May 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28502361/measuring-and-accounting-for-the-hawthorne-effect-during-a-direct-overt-observational-study-of-intensive-care-unit-nurses
#4
Sharon Lea Kurtz
BACKGROUND: Because suspecting nurses could alter hand hygiene (HH) behavior when observed, the goal of this article was to describe how the Hawthorne effect (HE) was measured and accounted for in a direct observational prospective study. METHODS: Observations were made 8 h/d for 3-5 days in 5 intensive care units (ICUs) (4 hospitals) on a convenience sample of 64 ICU nurses in Texas. The HE was measured so if hand hygiene adherence rates of the first 2 hours were 20% higher than the last 6 hours, the first 2 hours would be dropped and an additional 2 hours would be added at the end of the observation period...
May 10, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28500772/a-test-of-genomic-modularity-among-life-history-adaptations-promoting-speciation-with-gene-flow
#5
Gregory J Ragland, Meredith M Doellman, Peter Meyers, Glen R Hood, Scott P Egan, Thomas H Q Powell, Daniel A Hahn, Patrik Nosil, Jeffrey L Feder
Speciation-with-gene-flow may require adaptive divergence of multiple traits to generate strong ecologically based reproductive isolation. Extensive negative pleiotropy or physical linkage of genes in the wrong phase affecting these diverging traits may therefore hinder speciation, while genetic independence or 'modularity' among phenotypic traits may reduce constraints and facilitate divergence. Here, we test whether the genetics underlying two components of diapause life history, initial diapause intensity and diapause termination timing, constrain differentiation between sympatric hawthorn and apple-infesting host races of the fly Rhagoletis pomonella through analysis of 10,256 SNPs measured via Genotyping-By-Sequencing (GBS)...
May 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28500298/zbp1-phosphorylation-at-serine-181-regulates-its-dendritic-transport-and-the-development-of-dendritic-trees-of-hippocampal-neurons
#6
Anna S Urbanska, Aleksandra Janusz-Kaminska, Katarzyna Switon, Alicia L Hawthorne, Malgorzata Perycz, Malgorzata Urbanska, Gary J Bassell, Jacek Jaworski
Local protein synthesis occurs in axons and dendrites of neurons, enabling fast and spatially restricted responses to a dynamically changing extracellular environment. Prior to local translation, mRNA that is to be translated is packed into ribonucleoprotein particles (RNPs) where RNA binding proteins ensure mRNA silencing and provide a link to molecular motors. ZBP1 is a component of RNP transport particles and is known for its role in the local translation of β-actin mRNA. Its binding to mRNA is regulated by tyrosine 396 phosphorylation, and this particular modification was shown to be vital for axonal growth and dendritic branching...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494319/no-baby-booms-or-birth-sex-ratio-changes-following-fifty-shades-of-grey-in-the-united-states
#7
Victor Grech
INTRODUCTION: The Fifty Shades of Grey (FSOG) trilogy were publicised by the media as inflaming increased coital activity, and that this would result a baby boom. Furthermore, increased coital activity skews the sex ratio at birth (M/T) toward male births. This study was carried out in order to ascertain whether there were any spikes in total births or in M/T in the United States (US) circa nine months following the FSOG books. METHODS: Monthly male and female births for the US were obtained directly from the website of the Centre for Disease Control (01/2007-12/2015)...
May 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28486640/generalized-metabolic-bone-disease-and-fracture-risk-in-rothmund-thomson-syndrome
#8
Felicia Cao, Linchao Lu, Steven A Abrams, Keli M Hawthorne, Allison Tam, Weidong Jin, Brian Dawson, Roman Shypailo, Hao Liu, Brendan Lee, Sandesh Cs Nagamani, Lisa L Wang
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by poikiloderma, small stature, sparse hair, skeletal abnormalities, increased risk of osteosarcoma, and decreased bone mass. To date, there has not been a comprehensive evaluation of the prevalence and extent of metabolic bone disease in RTS. Furthermore, the mechanisms that result in this phenotype are largely unknown. In this report, we provide a detailed evaluation of 29 individuals with RTS with respect to their metabolic bone status including bone mineral density, calcium kinetics studies, and markers of bone remodeling...
May 9, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28469657/fermented-chinese-formula-shuan-tong-ling-attenuates-ischemic-stroke-by-inhibiting-inflammation-and-apoptosis
#9
Zhi-Gang Mei, Ling-Jing Tan, Jin-Feng Wang, Xiao-Li Li, Wei-Feng Huang, Hua-Jun Zhou
The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae (Gegen), salvia miltiorrhiza (Danshen), radix curcuma (Jianghuang), hawthorn (Shanzha), salvia chinensis (Shijianchuan), sinapis alba (Baijiezi), astragalus (Huangqi), panax japonicas (Zhujieshen), atractylodes macrocephala koidz (Baizhu), radix paeoniae alba (Baishao), bupleurum (Chaihu), chrysanthemum (Juhua), rhizoma cyperi (Xiangfu) and gastrodin (Tianma), whose aqueous extract was fermented with lactobacillus, bacillus aceticus and saccharomycetes...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28463630/safety-and-activity-of-varlilumab-a-novel-and-first-in-class-agonist-anti-cd27-antibody-in-patients-with-advanced-solid-tumors
#10
Howard A Burris, Jeffrey R Infante, Stephen M Ansell, John J Nemunaitis, Geoffrey R Weiss, Victor M Villalobos, Branimir I Sikic, Matthew H Taylor, Donald W Northfelt, William E Carson, Thomas R Hawthorne, Thomas A Davis, Michael J Yellin, Tibor Keler, Timothy Bullock
Purpose CD27, a costimulatory molecule on T cells, induces intracellular signals that mediate cellular activation, proliferation, effector function, and cell survival upon binding to its ligand, CD70. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors...
May 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28456322/electronic-monitoring-in-combination-with-direct-observation-as-a-means-to-significantly-improve-hand-hygiene-compliance
#11
REVIEW
John M Boyce
Monitoring hand hygiene compliance among health care personnel (HCP) is an essential element of hand hygiene promotion programs. Observation by trained auditors is considered the gold standard method for establishing hand hygiene compliance rates. Advantages of observational surveys include the unique ability to establish compliance with all of the World Health Organization "My 5 Moments for Hand Hygiene" initiative Moments and to provide just-in-time coaching. Disadvantages include the resources required for observational surveys, insufficient sample sizes, and nonstandardized methods of conducting observations...
May 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28437143/motivations-for-botanical-use-by-socioeconomically-diverse-urban-adults-does-evidence-support-motivation
#12
Grace F Duffy, Emily Stave Shupe, Marie Fanelli Kuczmarski, Alan B Zonderman, Michele K Evans
OBJECTIVE: The study objectives were to characterize botanical dietary supplement (BDS) use and to compare the motivations for botanical supplement (BS) use to the efficacy of the botanical in a socioeconomically and racially diverse urban adult population. METHODS: Subjects were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, a 20-year prospective health disparities study with African American and white adults from Baltimore, Maryland...
February 16, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28421679/thomas-starzl-visionary-and-xenotransplantation-pioneer-commentary-from-the-international-xenotransplant-association-vanguard-committee
#13
Wayne J Hawthorne, Arielle Cimeno, Mohamed Ezzelarab, Bynvant Sandhu, Christopher Burlak
No abstract text is available yet for this article.
March 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28417493/editorial-clinical-benefits-of-vitamin-d-therapy-in-inflammatory-bowel-disease
#14
EDITORIAL
A B Hawthorne
No abstract text is available yet for this article.
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28414468/1-3-dipolar-cycloaddition-reactions-of-low-valent-rhodium-and-iridium-complexes-with-arylnitrile-n-oxides
#15
Ilke Ugur, Sesil Agopcan Cinar, Burcu Dedeoglu, Viktorya Aviyente, M Frederick Hawthorne, Peng Liu, Fang Liu, K N Houk, Gonzalo Jiménez-Osés
The reactions between low-valent Rh(I) and Ir(I) metal-carbonyl complexes and arylnitrile oxides possess the electronic and structural features of 1,3-dipolar cycloadditions. Density functional theory (DFT) calculations on these reactions, involving both cyclopentadienyl and carboranyl ligands on the metal carbonyl, explain the ease of the chemical processes and the stabilities of the resulting metallaisoxazolin-5-ones. The metal-carbonyl bond has partial double bond character according to the Wiberg index calculated through NBO analysis, and so the reaction can be considered a normal 1,3-dipolar cycloaddition involving M═C bonds...
April 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28412449/targeted-drug-delivery-system-to-neural-cells-utilizes-the-nicotinic-acetylcholine-receptor
#16
Rachel Huey, Barry O'Hagan, Paul McCarron, Susan Hawthorne
Drug delivery to the brain is still a major challenge in the field of therapeutics, especially for large and hydrophilic compounds. In order to achieve drug delivery of therapeutic concentration in the central nervous system, the problematic blood brain barrier (BBB) must be overcome. This work presents the formulation of a targeted nanoparticle-based drug delivery system using a specific neural cell targeting ligand, rabies virus derived peptide (RDP). Characterization studies revealed that RDP could be conjugated to drug-loaded PLGA nanoparticles of average diameter 257...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28375974/creation-and-validation-of-a-photonumeric-scale-to-assess-volume-deficiency-in-the-infraorbital-region
#17
François Niforos, Steven Liew, Raj Acquilla, Patricia Ogilvie, Marva Safa, Massimo Signorini, Derek Jones, Jan Hawthorn, Caroline Collins, Graeme Kerson, Myooran Sithamparanathan
BACKGROUND: The eyes are particularly important aesthetic features of the face and revitalization of the infraorbital region has become a focus of aesthetic treatments. Published infraorbital scales to date have limitations in that they have been descriptive, subjective, or have used computer-generated images. Thus, there is an unmet need for a validated scale based on actual images. OBJECTIVE: To develop a practical photonumeric scale that respects the complex anatomy and age-related changes occurring in the orbital area...
May 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28357138/growth-of-infants-with-intestinal-failure-or-feeding-intolerance-does-not-follow-standard-growth-curves
#18
Danielle L Morton, Keli M Hawthorne, Carolyn E Moore
Objective. Infants with intestinal failure or feeding intolerance are nutritionally compromised and are at risk for extrauterine growth restriction. The aim of the study was to evaluate growth velocities of infants with intestinal failure and feeding intolerance for the first three months of age and to determine growth percentiles at birth and at 40-week postmenstrual age (PMA). Methods. A chart review of infants followed by the Texas Children's Hospital Intestinal Rehabilitation Team was conducted from April 2012 to October 2014...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28351843/five-minutes-with-kamila-hawthorne
#19
Abi Rimmer
No abstract text is available yet for this article.
March 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28337770/hypoglycemic-effect-of-hawthorn-in-type-ii-diabetes-mellitus-rat-model
#20
Aili Aierken, Tina Buchholz, Chen Chen, Xiaoying Zhang, Matthias F Melzig
BACKGROUND: Hawthorn is a popular herb in many different traditional medicine systems, including traditional Chinese medicine, where it has long been used for the treatment of hyperglycemia. However, most of its varied biological activities remain unexplored. This study investigated the hypoglycemic effect of hawthorn extracts in type II diabetic (T2DM) rat model. A total of 54 rats were randomly divided into six groups: normal control group; type II diabetic model group (T2DM; these rats were induced by high-fat diet and streptozotocin); high, middle and low concentrations of hawthorn treatment (HTH , HTM and HTL T2DM rats were given hawthorn extract at a dose of 50, 100 and 200 mg kg(-1) body weight, respectively); and positive control group (orlistat 40 mg kg(-1) body weight)...
March 23, 2017: Journal of the Science of Food and Agriculture
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