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https://www.readbyqxmd.com/read/28512713/matairesinol-suppresses-neuroinflammation-and-migration-associated-with-src-and-erk1-2-nf-%C3%AE%C2%BAb-pathway-in-activating-bv2-microglia
#1
Peng Xu, Meng-Wei Huang, Chen-Xi Xiao, Fen Long, Ying Wang, Si-Yu Liu, Wan-Wan Jia, Wei-Jun Wu, Di Yang, Jin-Feng Hu, Xin-Hua Liu, Yi-Zhun Zhu
Chronic neuroinflammation is a pathological feature of neurodegenerative diseases. Inhibition of microglia-mediated neuroinflammation might be a potential strategy for neurodegeneration. Matairesinol, a dibenzylbutyrolactone plant lignan, presents in a wide variety of foodstuffs. It has been found to possess anti-angiogenic, anti-oxidative, anti-cancer and anti-fungal activities. In the present study, we investigated the anti-neuroinflammation effects of matairesinol on lipopolysaccharide (LPS)-induced BV2 microglia cells and the related molecular mechanisms...
May 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28508631/reductive-bis-addition-of-aromatic-aldehydes-to-%C3%AE-%C3%AE-unsaturated-esters-via-the-use-of-sm-cu-i-in-air-a-route-to-the-construction-of-furofuran-lignans
#2
Yongjun Liu, Guang Tian, Jingjing Li, Yan Qi, Yonghong Wen, Feng Du
The novel bis-addition of benzaldehydes to acrylates or maleates was achieved by the direct use of samarium metal with the assistance of CuI under mild conditions under dry air, and the useful 2-hydroxylalkyl-γ-butyrolactons and lignan derivatives were thus constructed with high efficiency. The key factors that influence the reaction efficiency were investigated. The use of potassium iodide and molecular sieves as additives can improve the reaction efficiency remarkably.
May 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28507668/triflimide-catalyzed-allylsilane-annulations-of-benzylic-alcohols-for-the-divergent-synthesis-of-indanes-and-tetralins
#3
Jordan C T Reddel, Weiwei Wang, Kalli Koukounas, Regan J Thomson
The development of a triflimide-catalyzed annulation of benzylic alcohols with allylsilanes for the synthesis of indane or tetralin structures is reported. In this fragment coupling reaction, complexity is built rapidly from readily available starting materials to yield diverse sets of products with up to three contiguous stereocenters. Indanes or tetralins can be generated from common precursors depending on the structure of the allylsilane reagent used. The concise synthesis of several lignan natural products highlights the utility of this newly devised methodology...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28505094/antigiardial-activity-of-podophyllotoxin-type-lignans-from-bursera-fagaroides-var-fagaroides
#4
Filiberto Gutiérrez-Gutiérrez, Ana María Puebla-Pérez, Sirenia González-Pozos, José Manuel Hernández-Hernández, Armando Pérez-Rangel, Laura Patricia Alvarez, Gabriela Tapia-Pastrana, Araceli Castillo-Romero
Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD)...
May 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28504515/the-catalytically-lignan-activation-based-approach-for-the-synthesis-of-epi-podophyllotoxin-derivatives
#5
Jun-Hao Wan, Yang Hu, Hui Liu, Yuan-Hong Tu, Zhong-Yi He, Jian-Song Sun
Under the effect of catalytic amount of Au(I) complex, 4-O-(2-cyclopropylethynyl)benzoyl-(epi)-podophyllotoxins, easily prepared via dehydrative condensation between (epi)-podophyllotoxin and ortho-cyclopropylethynylbenzoic acid, could couple with a variety of nucleophiles, including alcohol, phenol, aniline, and carbon nucleophiles efficiently to provide (epi)-podophyllotoxin derivatives. Thus, the first catalytic and lignan-activation-based approach for (epi)-podophyllotoxin derivatization was established...
May 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28502906/anti-inflammatory-effects-of-forsythia-suspensa-in-dextran-sulfate-sodium-induced-colitis
#6
Youn-Hwan Hwang, Dong-Gun Kim, Wei Li, Hye Jin Yang, Nam-Hui Yim, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS. MATERIALS AND METHODS: After the induction of colitis using 3% dextran sulfate sodium, FS (100mg/kg/day) was administered orally during the experimental period...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28501003/phytochemicals-for-taming-agitated-immune-endocrine-neural-axis
#7
REVIEW
Seema Patel
Homeostasis of immune-endocrine-neural axis is paramount for human health. If this axis gets agitated due to age, genetic variations, environmental exposures or lifestyle assaults, a cascade of adverse reactions occurs in human body. Cytokines, hormones and neurotransmitters, the effector molecules of this axis behave erratically, leading to a gamut of neural, endocrine, autoimmune, and metabolic diseases. Current panel of drugs can tackle some of them but not in a sustainable, benign way as a myriad of side effects, causal of them have been documented...
May 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#8
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28498356/nine-different-chemical-species-and-action-mechanisms-of-pancreatic-lipase-ligands-screened-out-from-forsythia-suspensa-leaves-all-at-one-time
#9
Tinggui Chen, Yayun Li, Liwei Zhang
It is difficult to screen out as many active components as possible from natural plants all at one time. In this study, subfractions of Forsythia suspensa leaves were firstly prepared; then, their inhibitive abilities on pancreatic lipase were tested; finally, the highest inhibiting subfraction was screened by self-made immobilized pancreatic lipase. Results showed that nine ligands, including eight inhibitors and one promotor, were screened out all at one time. They were three flavonoids (rutin, IC50: 149 ± 6...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28495081/phytochemical-and-cytotoxic-studies-on-the-leaves-of-calotropis-gigantea
#10
Khang D H Nguyen, Phu H Dang, Hai X Nguyen, Mai T T Nguyen, Suresh Awale, Nhan T Nguyen
A new lignan, 9'-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4-12) have been isolated from the active fractions, CHCl3 (IC50, 0.32μgmL(-1)) and EtOAc (IC50, 0.55μgmL(-1)) fractions of the leaves of Calotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds 1 and 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC50 values of 3...
April 29, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28494583/isolation-identification-and-biological-evaluation-of-phenolic-compounds-from-the-traditional-north-american-confectionery-maple-sugar
#11
Yongqiang Liu, Kenneth Rose, Nicholas Dasilva, Shelby Johnson, Navindra P Seeram
Maple sap, collected from the sugar maple (Acer saccharum) tree, is boiled to produce the popular plant-derived sweetener, maple syrup, which can then be further evaporated to yield the traditional North American confectionery, maple sugar. While maple sap and maple syrup have been previously studied, the phytochemical constituents of maple sugar are unknown. Herein, thirty phenolic compounds, 1-30, primarily lignans, were isolated and identified (by HRESIMS and NMR) from maple sugar. The isolates included the phenylpropanoid-based lignan tetramers, (erythro,erythro)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9';7',9-diepoxy-4,8'';4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol, 29, and (threo,erythro)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9';7',9-diepoxy-4,8'';4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol, 30, neither of which have been identified from maple sap or maple syrup before...
May 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28488417/melanogenesis-inhibitory-and-antioxidant-activities-of-phenolics-from-periploca-forrestii
#12
Cai-Ling Sun, Lei Chen, Jian Xu, Wei Qu, Li Guan, Wen-Yuan Liu, Toshihiro Akihisa, Feng Feng, Jie Zhang
Two new tetrahydrofuran-type lignans, (-)-gentioluteol-9-O-β-D-glucoside (1), (-)-berchemol 9-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (2), along with sixteen known compounds 3-18 were isolated from the 95% EtOH extract of the stems of Periploca forrestii. The structures of new tetrahydrofuran-type lignans were determined by HR-ESI-MS and various NMR techniques in combination with CD method. Then, their antioxidant abilities were evaluated by 1,1-diphenyl-2-picrylhydrazul (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, and ferric-reducing antioxidant power (FRAP) assays...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28487651/mechanism-underlying-the-reversal-of-drug-resistance-in-p-glycoprotein-expressing-leukemia-cells-by-pinoresinol-and-the-study-of-a-derivative
#13
María L González, D Mariano A Vera, Jerónimo Laiolo, Mariana B Joray, Mariana Maccioni, Sara M Palacios, Gabriela Molina, Priscila A Lanza, Samanta Gancedo, Vivian Rumjanek, María C Carpinella
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful therapy. With the aim of finding agents that circumvent the MDR phenotype mediated by P-gp, 15 compounds isolated from native and naturalized plants of Argentina were screened. Among these, the non-cytotoxic lignan (±) pinoresinol successfully restored sensitivity to doxorubicin from 7 μM in the P-gp overexpressed human myelogenous leukemia cells, Lucena 1...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28486830/ethnomedicinal-uses-phytochemistry-and-pharmacological-aspects-of-the-genus-premna-a-review
#14
Roza Dianita, Ibrahim Jantan
CONTEXT: The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases. OBJECTIVES: This review exhaustively gathers available information on ethnopharmacological uses, phytochemistry, and bioactivity studies on more than 20 species of Premna and critically analyzes the reports to provide the perspectives and directions for future research for the plants as potential source of drug leads and pharmaceutical agents...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28485479/proteasome-as-a-new-target-for-bio-inspired-benzo-k-l-xanthene-lignans
#15
Angela Capolupo, Alessandra Tosco, Matteo Mozzicafreddo, Corrado Tringali, Nunzio Cardullo, Maria Chiara Monti, Agostino Casapullo
Mass spectrometry-based chemical proteomics is a powerful tool in the target discovery of small molecules. Here we present the application of this approach to define the target profile of bio-inspired synthetic benzo[k,l]xanthene lignans, endowed with interesting biological properties. Proteasome has been identified as a new main interactor for this class of compounds. A combination of molecular docking and in vitro and in cell fluorescence assays gave insights on the molecular mechanism of interaction, highlighting the the attitude of these lignans to inhibit the proteasome...
May 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28476319/simultaneous-determination-of-components-with-wide-polarity-and-content-ranges-in-cistanche-tubulosa-using-serially-coupled-reverse-phase-hydrophilic-interaction-chromatography-tandem-mass-spectrometry
#16
Yu Yan, Qingqing Song, Xiaojia Chen, Jun Li, Peng Li, Yitao Wang, Tongxiang Liu, Yuelin Song, Pengfei Tu
To meet the demands from plant physiologists and pharmacognosists, sustainable efforts are being devoted by the analytical chemists from all over the world to search an approach being capable of simultaneously monitoring primary along with secondary metabolites. The key technical bottlenecks currently lie at affording satisfactory chromatographic and spectrometric performances for both hydrophilic and hydrophobic substances that span a great content range. Herein, reverse phase liquid chromatography was directly coupled with hydrophilic interaction chromatography, namely RPLC-HILIC, to integrate their merits, whereas dilution pumps were employed to tackle the mismatching for the mobile phase between them...
June 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28472971/larvicidal-activity-of-lignans-and-alkaloid-identified-in-zanthoxylum-piperitum-bark-toward-insecticide-susceptible-and-wild-culex-pipiens-pallens-and-aedes-aegypti
#17
Soon-Il Kim, Young-Joon Ahn
BACKGROUND: The yellow fever mosquito, Aedes aegypti, and the common house mosquito, Culex pipiens pallens, transmit dengue fever and West Nile virus diseases, respectively. This study was conducted to determine the toxicity of the three lignans (-)-asarinin, sesamin and (+)-xanthoxylol-γ,γ-dimethylallylether (XDA), and the alkaloid pellitorine from Zanthoxylum piperitum (Rutaceae) bark to third-instar larvae from insecticide-susceptible C. pipiens pallens and Ae. aegypti as well as wild C...
May 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28472349/dirigent-proteins-in-plants-modulating-cell-wall-metabolism-during-abiotic-and-biotic-stress-exposure
#18
Candelas Paniagua, Anna Bilkova, Phil Jackson, Siarhei Dabravolski, Willi Riber, Vojtech Didi, Josef Houser, Nora Gigli-Bisceglia, Michaela Wimmerova, Eva Budinska, Thorsten Hamann, Jan Hejatko
Dirigent (DIR) proteins were found to mediate regio- and stereoselectivity of bimolecular phenoxy radical coupling during lignan biosynthesis. Here we summarize the current knowledge of the importance of DIR proteins in lignan and lignin biosynthesis and highlight their possible importance in plant development. We focus on the still rather enigmatic Arabidopsis DIR gene family, discussing the few members with known functional importance. We comment on recent discoveries describing the detailed structure of two DIR proteins with implications in the mechanism of DIR-mediated catalysis...
May 3, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28472215/dietary-flavonoid-and-lignan-intake-and-mortality-in-prospective-cohort-studies-systematic-review-and-dose-response-meta-analysis
#19
Giuseppe Grosso, Agnieszka Micek, Justyna Godos, Andrzej Pajak, Salvatore Sciacca, Fabio Galvano, Edward L Giovannucci
Recent evidence has suggested that flavonoid and lignan intake may be associated with decreased risk of chronic and degenerative diseases. The aim of this meta-analysis was to assess the association between dietary flavonoid and lignan intake and all-cause and cardiovascular disease (CVD) mortality in prospective cohort studies. A systematic search was conducted in electronic databases to identify studies published from January 1996 to December 2015 that satisfied inclusion/exclusion criteria. Risk ratios and 95% confidence intervals were extracted and analyzed using a random-effects model...
May 3, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28471331/study-on-the-pharmacokinetics-of-deoxyschizandrin-and-schizandrin-in-combination-with-epigallocatechin-gallate-a-component-of-green-tea-in-rats
#20
Yan Liu, Dong Zhang, Yingli Wang, Wenjuan Zhang, Xiaohong Liu
1. Green tea is commonly used worldwide due to its potential positive health benefits. We have examined the effects of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, on the pharmacokinetics of deoxyschizandrin (DSD) and schizandrin (SD), which are the representative lignans in popular traditional Chinese medicines Fructus schisandrae, in rats. 2. The effects on the transport in Caco-2 cells and metabolism in human liver microsomes of DSD and SD by EGCG were determined to analyze their interactions thoroughly...
May 4, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
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