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https://www.readbyqxmd.com/read/28333453/neuroprotective-lignans-from-the-fruits-of-schisandra-bicolor-var-tuberculata
#1
Ye Liu, Heng-Yi Yu, Yan-Mei Wang, Tian Tian, Wen-Ming Wu, Ming Zhou, Xiang-Gao Meng, Han-Li Ruan
Nine new lignans (1-9) and ten known analogues (10-19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1-9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds 2-9 were deduced by comparing their experimental ECD spectra and optical rotations with those of compound 1 or similar compounds...
March 23, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28327647/microrna-expression-profiles-during-cotton-gossypium-hirsutum-l-fiber-early-development
#2
Min Wang, Runrun Sun, Chao Li, Qinglian Wang, Baohong Zhang
The role of microRNAs (miRNAs) during cotton fiber development remains unclear. Here, a total of 54 miRNAs belonging to 39 families were selected to characterize miRNA regulatory mechanism in eight different fiber development stages in upland cotton cv BM-1. Among 54 miRNAs, 18 miRNAs were involved in cotton fiber initiation and eight miRNAs were related to fiber elongation and secondary wall biosynthesis. Additionally, 3,576 protein-coding genes were candidate target genes of these miRNAs, which are potentially involved in cotton fiber development...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323486/enterolactone-induces-g1-phase-cell-cycle-arrest-in-nonsmall-cell-lung-cancer-cells-by-downregulating-cyclins-and-cyclin-dependent-kinases
#3
Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Melpo Christofidou-Solomidou, Katie M Reindl
Flaxseed is a rich source of the plant lignan secoisolariciresinol diglucoside (SDG), which is metabolized into mammalian lignans enterodiol (ED) and enterolactone (EL) in the digestive tract. The anticancer properties of these lignans have been demonstrated for various cancer types, but have not been studied for lung cancer. In this study, we investigated the anticancer effects of EL for several nonsmall cell lung cancer (NSCLC) cell lines of various genetic backgrounds. EL inhibited the growth of A549, H441, and H520 lung cancer cells in concentration- and time-dependent manners...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28317736/evaluation-of-phenolic-profile-and-antioxidant-capacity-in-gluten-free-flours
#4
Gabriele Rocchetti, Giulia Chiodelli, Gianluca Giuberti, Francesco Masoero, Marco Trevisan, Luigi Lucini
The characterization of phenolic fingerprints in common gluten-free flours is still scarce. Total phenolic and anthocyanin contents, antioxidant capacity and the entire phenolic profile were investigated for extracts from chickpea, sorghum, quinoa, black rice, lentil, amaranth, brown rice, oat and white rice flours, using soft wheat flour as a comparison. The highest phenolic content was found in black rice, followed by quinoa extracts (147.9 and 87.2mg gallic acid equivalents 100g(-1), respectively). Consistently, antioxidant capacity was highest in black rice and quinoa flours (34mmol trolox equivalents 100g(-1)), while anthocyanins were highest in black rice flour...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317728/direct-study-of-minor-extra-virgin-olive-oil-components-without-any-sample-modification-1-h-nmr-multisupression-experiment-a-powerful-tool
#5
Ainhoa Ruiz-Aracama, Encarnación Goicoechea, María D Guillén
Proton Nuclear Magnetic Resonance ((1)H NMR) was employed to study monovarietal commercial Spanish extra-virgin olive oils (EVOO) (Arbequina, Arroniz, Cornicabra, Hojiblanca and Picual). Each sample was analyzed by a standard pulse and by an experiment suppressing the main lipid signals, enabling the detection of signals of minor components. The aim was to determine the possibilities of both (1)H NMR approaches to characterize EVOO composition, focusing on acyl groups, squalene, sterols, triterpene acids/esters, fatty alcohols, wax esters and phenols (lignans, tyrosol, hydroxytyrosol, oleocanthal, oleacein, oleokoronal, oleomissional, ligstrodials and oleuropeindials), and to determine hydrolysis and oxidation levels...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28303415/anti-inflammatory-effects-of-schisandrin-b-on-lps-stimulated-bv2-microglia-via-activating-ppar-%C3%AE
#6
Na Liu, Jin-Xu Zheng, Yuan-Su Zhuang, Zhi-Kui Zhou, Jin-Hua Zhao, Lei Yang
Schisandrin B (Sch B), a dibenzocyclooctadiene lignan isolated from Schisandra chinensis (Turcz.) Baill, has been shown to have anti-inflammatory effect. The purpose of this study was to evaluate the effect of Sch B on LPS-induced inflammation in microglia and to investigate the molecular targets of Sch B. BV2 cells were stimulated by LPS in the presence or absence of Sch B. The results showed that the levels of TNF-α, IL-6, IL-1β, and PGE2 upregulated by LPS were significantly suppressed by Sch B. LPS-induced NF-κB activation was also inhibited by Sch B...
March 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28303223/four-new-phenolic-glycosides-from-baoyuan-decoction
#7
Xiaoli Ma, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang
Four new phenolic glycosides, including two flavonoid glycosides (1 and 2) and two lignan glycosides (3 and 4), were isolated from the traditional Chinese medicine formula, Baoyuan decoction. Their structures were established by detailed analysis of the NMR and HR-ESI-MS spectroscopic data and their absolute configurations were determined by the experimental electronic circular dichroism data as well as chemical methods. Furthermore, the sources of the four new compounds were determined by the UPLC-Qtrap-MS method, which proved that 1 and 2 are originated from Glycyrrhiza uralensis, and 3 and 4 are from Cinnamomum cassia...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28299617/methyl-caffeate-and-some-plant-constituents-inhibit-age-related-inflammation-effects-on-senescence-associated-secretory-phenotype-sasp-formation
#8
Hyun Lim, Byung Kyu Park, Sook Young Shin, Yong Soo Kwon, Hyun Pyo Kim
During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin. Several plant constituents showed considerable inhibition of IL-6 production, a representative SASP marker. These plant constituents included anthraquinones such as aurantio-obtusin, flavonoids including astragalin, iristectorigenin A, iristectorigenin B, linarin, lignans including lariciresinol 9-O-glucoside and eleutheroside E, phenylpropanoids such as caffeic acid and methyl caffeate, steroid (ophiopogonin), and others like centauroside, rhoifolin and scoparone...
March 15, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28294620/the-effect-of-antibiotics-and-diet-on-enterolactone-concentration-and-metabolome-studied-by-targeted-and-non-targeted-lc-ms-metabolomics
#9
Anne Katrine Bolvig, Natalja P Nørskov, Mette Skou Hedemann, Leslie Foldager, Brendan McCarthy-Sinclair, Maria L Marco, Helle N Lærke, Knud Erik Bach Knudsen
High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. Here, we investigate the link between antibiotic use and lignan metabolism in pigs using LC-MS/MS. The effect of lignan intake and antibiotic use on the gut microbial community and the pig metabolome is studied by 16S rRNA sequencing and non-targeted LC-MS...
March 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28290284/uhplc-ms-2-based-approach-for-the-comprehensive-metabolite-profiling-of-bean-vicia-faba-l-by-products-a-promising-source-of-bioactive-constituents
#10
Ibrahim M Abu-Reidah, David Arráez-Román, Ismail Warad, Alberto Fernández-Gutiérrez, Antonio Segura-Carretero
Today, by-products generated from the agro-industrial practices are considered a key source of bioactive and functional components, that can be used for their nutritional and added value properties. New aspects concerning the use of these wastes as by-products in food production additives or supplements with high nutritional and medicinal value have gained substantial interest, due to their possession of economically high-value products. In this sense, the present study describes a thorough characterization of phytochemical compounds from hydro-methanolic extract of broad beans testa by using ultra-high performance liquid chromatography (UHPLC) hyphenated with quadrupole-time-of-flight tandem mass spectrometry (QTOF-MS)...
March 2017: Food Research International
https://www.readbyqxmd.com/read/28284081/an-integrated-strategy-using-uplc-qtof-ms-e-and-uplc-qtof-mrm-enhanced-target-for-pharmacokinetics-study-of-wine-processed-schisandra-chinensis-fructus-in-rats
#11
Kuangyi Liu, Yonggui Song, Yali Liu, Mi Peng, Hanyun Li, Xueliang Li, Bingwei Feng, Pengfei Xu, Dan Su
Currently the pharmacokinetic (PK) research of herbal medicines is still limited and facing critical technical challenges on quantitative analysis of multi-components from biological matrices which often accompanied by lacking of authentic standards and low concentration. This present work contributes to the development of an integrated strategy for extensive pharmacokinetics assessments, and a selective and sensitive method independent of authentic standards for multi-components analysis based on the use of ultra-performance liquid chromatography/quadrupole-time-of-flight/MS(E) (UPLC-TOF-MS(E)) and UPLC-TOF-MRM (rnhanced target)...
February 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28279068/%C3%AE-catenin-mediates-anti-adipogenic-and-anticancer-effects-of-arctigenin-in-preadipocytes-and-breast-cancer-cells
#12
Jihye Lee, Jee-Young Imm, Seong-Ho Lee
Arctigenin is a lignan abundant in Asteraceae plants and has anti-inflammatory, antiobesity, and anticancer activities. Obesity is one of the leading causes of several types of cancers including breast cancer. The current study was performed to investigate if arctigenin suppresses differentiation of preadipocytes and proliferation of breast cancer cells and to explore potential molecular mechanisms. Treatment of arctigenin reduced lipid accumulation in differentiated 3T3-L1 adipocytes in a dose- and time-dependent manner without toxicity...
March 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28278686/two-new-lignans-from-saururus-chinensis
#13
Cuibai Li, Ningxin Li, Jiarui Yue, Qishi Song, Qingfei Fan
Two new lignans, (Z)-14-bis(3',4'-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo-2-methyl-3-oxo-1-(3',4',5'-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3-17) were isolated from Saururus chinensis. Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activity was screened by MTT assay, compounds 1, 2, 3, 5, 9-11 and 13-15 showed no cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines...
February 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28278224/ampk-modulatory-activity-of-olive-tree-leaves-phenolic-compounds-bioassay-guided-isolation-on-adipocyte-model-and-in-silico-approach
#14
Cecilia Jiménez-Sánchez, Mariló Olivares-Vicente, Celia Rodríguez-Pérez, María Herranz-López, Jesús Lozano-Sánchez, Antonio Segura-Carretero, Alberto Fernández-Gutiérrez, José Antonio Encinar, Vicente Micol
SCOPE: Olive-tree polyphenols have demonstrated potential for the management of obesity-related pathologies. We aimed to explore the capacity of Olive-tree leaves extract to modulate triglyceride accumulation and AMP-activated protein kinase activity (AMPK) on a hypertrophic adipocyte model. METHODS: Intracellular triglycerides and AMPK activity were measured on the hypertrophic 3T3-L1 adipocyte model by AdipoRed and immunofluorescence microscopy, respectively. Reverse phase high performance liquid chromatography coupled to time-of-flight mass detection with electrospray ionization (RP-HPLC-ESI-TOF/MS) was used for the fractionation of the extract and the identification of the compounds...
2017: PloS One
https://www.readbyqxmd.com/read/28275053/inhibiting-clathrin-mediated-endocytosis-of-the-leucine-rich-g-protein-coupled-receptor-5-diminishes-cell-fitness
#15
Joshua C Snyder, Lauren K Rochelle, Caroline Ray, Thomas F Pack, Cheryl B Bock, Veronica Lubkov, H Kim Lyerly, Alan S Waggoner, Larry S Barak, Marc G Caron
The leucine-rich G protein-coupled receptor-5 (LGR5) is expressed in adult tissue stem cells of many epithelia and its overexpression is negatively correlated with cancer prognosis. LGR5 potentiates WNT/β-catenin signaling through its unique constitutive internalization property that clears negative regulators of the WNT-receptor complex from the membrane. However, both the mechanism and physiological relevance of LGR5 internalization is unclear. Therefore, a natural product library was screened to discover LGR5 internalization inhibitors and gain mechanistic insight into LGR5 internalization...
March 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28273165/transcriptome-profiling-of-influenza-a-virus-infected-lung-epithelial-a549-cells-with-lariciresinol-4-%C3%AE-d-glucopyranoside-treatment
#16
Beixian Zhou, Jing Li, Xiaoli Liang, Zifeng Yang, Zhihong Jiang
The influenza A virus is an acute contagious pathogen that affects the human respiratory system and can cause severe lung disease and even death. Lariciresinol-4-β-D-glucopyranoside is a lignan that is extracted from Isatis indigotica, which is a medicinal herb plant that was commonly applied to treat infections, the common cold, fever and inflammatory diseases. Our previous study demonstrated that lariciresinol-4-β-D-glucopyranoside possesses anti-viral and anti-inflammatory properties. However, the comprehensive and detailed mechanisms that underlie the effect of lariciresinol-4-β-D-glucopyranoside interventions against influenza virus infection remain to be elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/28264475/association-between-dietary-share-of-ultra-processed-foods-and-urinary-concentrations-of-phytoestrogens-in-the-us
#17
Eurídice Martínez Steele, Carlos A Monteiro
The aim of this study was to examine the relationship between dietary contribution of ultra-processed foods and urinary phytoestrogen concentrations in the US. Participants from cross-sectional 2009-2010 National Health and Nutrition Examination Survey aged 6+ years, selected to measure urinary phytoestrogens and with one 24-h dietary recall were evaluated (2692 participants). Food items were classified according to NOVA (a name, not an acronym), a four-group food classification based on the extent and purpose of industrial food processing...
February 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28264205/chemical-composition-antiprotozoal-and-cytotoxic-activities-of-indole-alkaloids-and-benzofuran-neolignan-of-aristolochia-cordigera
#18
Marcos D P Pereira, Tito da Silva, Anna Caroline C Aguiar, Glaucius Oliva, Rafael V C Guido, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana, Lucia M X Lopes
This is a comparative study on the intraspecific chemical variability of Aristolochia cordigera species, collected in two different regions of Brazil, Biome Cerrado (semiarid) and Biome Amazônia (coastal). The use of GC-MS and statistical methods led to the identification of 56 compounds. A higher percentage of palmitone and germacrene-D in the hexanes extracts of the leaves of plants from these respective biomes was observed. Phytochemical studies on the extracts led to the isolation and identification of 19 known compounds, including lignans, neolignans, aristolochic acids, indole-β-carboline, and indole alkaloids...
March 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28246539/schisandra-lignan-extract-protects-against-carbon-tetrachloride-induced-liver-injury-in-mice-by-inhibiting-oxidative-stress-and-regulating-the-nf-%C3%AE%C2%BAb-and-jnk-signaling-pathways
#19
Qingshan Chen, Qi Zhan, Ying Li, Sen Sun, Liang Zhao, Hai Zhang, Guoqing Zhang
Schisandra chinensis (S. chinensis) is a traditional Chinese herbal medicine widely used for the treatment of liver disease, whose main active components are lignans. However, the action mechanisms of the lignans in S. chinensis remain unclear. This study aimed to investigate the protective effect and related molecular mechanism of Schisandra lignan extract (SLE) against carbon tetrachloride- (CCl4-) induced acute liver injury in mice. Different doses of SLE at 50, 100, and 200 mg/kg were administered daily by gavage for 5 days before CCl4 treatment...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28243901/the-genus-carissa-an-ethnopharmacological-phytochemical-and-pharmacological-review
#20
REVIEW
Joseph Sakah Kaunda, Ying-Jun Zhang
Carissa L. is a genus of the family Apocynaceae, with about 36 species as evergreen shrubs or small trees native to tropical and subtropical regions of Africa, Asia and Oceania. Most of Carissa plants have been employed and utilized in traditional medicine for various ailments, such as headache, chest complains, rheumatism, oedema, gonorrhoea, syphilis, rabies. So far, only nine Carissa species have been phytochemically studied, which led to the identification of 123 compounds including terpenes, flavonoids, lignans, sterols, simple phenolic compounds, fatty acids and esters, and so on...
February 27, 2017: Natural Products and Bioprospecting
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