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https://www.readbyqxmd.com/read/29032105/a-comprehensive-review-on-the-anti-cancer-properties-and-mechanisms-of-action-of-sesamin-a-lignan-in-sesame-seeds-sesamum-indicum
#1
REVIEW
Amin F Majdalawieh, Mariam Massri, Gheyath K Nasrallah
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its anti-proliferative, pro-apoptotic, anti-inflammatory, anti-metastatic, anti- and pro-angiogenic, and pro-autophagocytic activities. In this review, we provide a comprehensive summary of the reported anti-cancer effects of sesamin, both in vitro and in vivo. Experimental findings related to the potential of sesamin to attenuate oxidative stress, inflammation, proliferation, metastasis, and angiogenesis in various cancer cells and tumors are analyzed...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29027559/photosensitised-regioselective-2-2-cycloaddition-of-cinnamates-and-related-alkenes
#2
Santosh K Pagire, Asik Hossain, Lukas Traub, Sabine Kerres, Oliver Reiser
An efficient method for the synthesis of substituted cyclobutanes from cinnamates, chalcones, and styrenes has been developed utilizing a visible-light triplet sensitisation mode. This reaction provides a diverse range of substituted cyclobutanes in high yields under mild conditions without the need of external additives. Good regioselectivity is obtained due to strong π-π-stacking of arene moieties, whereas diastereoselectivity relies on the electronic effects or ortho-substitution of the arene substrate...
October 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28991379/a-target-and-non-target-strategy-for-identification-or-characterization-of-the-chemical-ingredients-in-chinese-herb-preparation-shuang-huang-lian-oral-liquid-by-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#3
Feng-Xiang Zhang, Min Li, Zhi-Hong Yao, Chang Li, Li-Rui Qiao, Xiu-Yu Shen, Kate Yu, Yi Dai, Xin-Sheng Yao
A target and non-target strategy based on in-house chemical components library was developed for rapid and comprehensive analysis of complicated components from traditional Chinese medicine (TCM) preparation Shuang-Huang-Lian oral liquid (SHL). The sample was analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Qtof MS) using generic acquisition parameters. Automated detection and data filtering were performed on the UNIFI(TM) software and the detected peaks were evaluated against an in-house library...
October 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28990509/potential-of-plant-sourced-phenols-for-inflammatory-bowel-disease
#4
Hai-Tao Xiao, Bo Wen, Xiang-Chun Shen, Zhao-Xiang Bian
Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop the strategies meet the stringent safety and effectiveness in the long-term treatment are urgent in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols, such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids, cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation through improvement of colonic oxidative and pro-inflammatory status, preservation of the epithelial barrier function and modulation of gut microbiota...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28990504/polyphenols-in-food-cancer-prevention-and-apoptosis-induction
#5
Ashita Sharma, Mandeep Kaur, Jatinder Kaur Katnoria, Avinash Kaur Nagpal
Polyphenols are group of water-soluble organic compounds, mainly of natural origin. The compounds having about 5-7 aromatic rings and more than 12 phenolic hydroxyl groups are classified as polyphenols. These are the antioxidants which protect the body from oxidative damage. In plants, they are the secondary metabolites produced as a defense mechanism against stress factors. Antioxidant property of polyphenols is suggested to provide protection against many diseases associated with reactive oxygen species (ROS), including cancer...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28990331/antimalarial-and-antileishmanial-activities-of-phytophenolics-and-their-synthetic-analogues
#6
Masanori Morimoto, Charles L Cantrell, Shabana Khan, Babu L Tekwani, Stephen O Duke
Thirty-seven phytophenolics and their synthetic analogues were evaluated for activity against two protozoal pathogens, Leishmania donovani and Plasmodium falciparum (D6 and W2 clones), respectively. 4,6-Dimethoxyaurone demonstrated the highest activity with IC50 values of 13.2 μM and 16.9 μM against L. donovani and P. falciparum (W2 clone), respectively, without undesired cytotoxicity against VERO cells. The moiety having two benzene rings was critical to maintain the antiprotozoal activities based on the observation that both coumaranones and chromones were inactive while other test compounds, including coumarans and aurones, remained active...
October 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28983308/induced-mutagenesis-in-ugt74s1-gene-leads-to-stable-new-flax-lines-with-altered-secoisolariciresinol-diglucoside-sdg-profiles
#7
Bourlaye Fofana, Kaushik Ghose, Ashok Somalraju, Jason McCallum, David Main, Michael K Deyholos, Gordon G Rowland, Sylvie Cloutier
Flax secoisolariciresinol (SECO) diglucoside (SDG) lignan is an emerging natural product purported to prevent chronic diseases in humans. SECO, the aglycone form of SDG, has shown higher intestinal cell absorption but it is not accumulated naturally in planta. Recently, we have identified and characterized a UDP-glucosyltransferase gene, UGT74S1, that glucosylates SECO into its monoglucoside (SMG) and SDG forms when expressed in yeast. However, whether this gene is unique in controlling SECO glucosylation into SDG in planta is unclear...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28982254/biotransformation-of-cubebin-by-aspergillus-spp-into-hinokinin-and-parabenzlactone-and-their-evaluation-against-oral-pathogenic-bacteria
#8
Caroline Arruda, Daniele de Souza Eugênio, Monique Rodrigues Moreira, Guilherme Venâncio Símaro, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins, Márcio Luís Andrade Silva, Rodrigo Cássio Sola Veneziani, Paula Bruzadelle Vieira, Sérgio R Ambrósio
The biotransformation of the lignan (-)-cubebin by filamentous fungi Aspergillus terreus and Aspergillus niger is an efficient bioprocess for obtaining (-)-hinokinin and (-)-parabenzlactone. The relevance of getting (-)-hinokinin is due to its promising effect against oral pathogens, especially S. sanguinis (both MIC and MBC 12.5 μg/mL), and other previous reported effects against Chagas disease and as anti-inflammatory. The advantage of using fungal transformation is the use of non-toxic and/or non-pollutant reagents and/or solvents in comparison with semi-synthesis...
October 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28978677/rye-bran-modified-with-cell-wall-degrading-enzymes-influences-the-kinetics-of-plant-lignans-but-not-of-enterolignans-in-multicatheterized-pigs
#9
Anne K Bolvig, Natalja P Nørskov, Sophie van Vliet, Leslie Foldager, Mihai V Curtasu, Mette S Hedemann, Jens F Sørensen, Helle N Lærke, Knud E Bach Knudsen
Background: Whole-grain intake is associated with a lower risk of chronic Western-style diseases, possibly brought about by the high concentration of phytochemicals, among them plant lignans (PLs), in the grains.Objective: We studied whether treatment of rye bran with cell wall-degrading enzymes changed the solubility and kinetics of PLs in multicatheterized pigs.Methods: Ten female Duroc × Danish Landrace × Yorkshire pigs (60.3 ± 2.3 kg at surgery) fitted with permanent catheters were included in an incomplete crossover study...
October 4, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28972885/comparative-effects-of-schisandrin-a-b-and-c-on-propionibacterium-acnes-induced-nlrp3-inflammasome-activation-mediated-il-1%C3%AE-secretion-and-pyroptosis
#10
Miaomiao Guo, Faliang An, Haiyuan Yu, Xing Wei, Minhua Hong, Yanhua Lu
Propionibacterium acnes, a common pathogen associated with acne, is also responsible for various surgical infections. Schisandrin A, schisandrin B and schisandrin C, the representative lignans of Schisandra chinensis (Turcz.) Baill. extract, inhibit P. acnes-induced inflammation. However, their effects on P. acnes-induced IL-1β secretion and pyroptosis mediated by NLRP3 inflammasome activation remain unknown. In this study, we compared the effects of schisandrin A, B, and C (Sch A, B, and C) on IL-1β secretion and pyroptosis in P...
September 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28964370/metabolic-fingerprinting-of-must-obtained-from-sun-dried-grapes-of-two-indigenous-cypriot-cultivars-destined-for-the-production-of-commandaria-a-protected-destignation-of-origin-product
#11
Savvas Constantinou, Ana Maria Gómez-Caravaca, Vlasios Goulas, Antonio Segura-Carretero, George A Manganaris
Grapes's sun-dried process is one of the most critical steps in the production of 'Commandaria', a dessert wine product that is exclusively produced in Cyprus and derived from must obtained from two indigenous grape cultivars, namely 'Mavro' and 'Xynisteri'. Despite its significant economic importance, no data regarding the primary and secondary metabolites of the aforementioned cultivars exist. Thus, in the current study, the effect of sun drying process on the qualitative attributes and phenolic profile of 'Mavro' and 'Xynisteri' musts was dissected...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28964368/changes-in-phenolic-composition-in-olive-tree-parts-according-to-development-stage
#12
Leila Abaza, Amani Taamalli, David Arráez-Román, Antonio Segura-Carretero, Alberto Fernández-Gutierrérez, Mokhtar Zarrouk, Nabil Ben Youssef
The aim of this study was to investigate the changes in the phenolic profile in different organs (buds, flowers, fruits and leaves) from Chemlali olive variety cultivated in the Center of Tunisia according to development stage. Phenolics recovery was carried out using aqueous methanol from freeze-dried powdered tissues. The extracts were then analyzed by using high performance liquid chromatography coupled to time of flight and ion trap mass spectrometry detectors. Qualitatively, secoiridoids, flavonoids, simple phenols, cinnamic acid derivatives and lignans were identified in the analyzed extracts...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28961176/phytoestrogen-concentrations-in-human-urine-as-biomarkers-for-dietary-phytoestrogen-intake-in-mexican-women
#13
Karina M Chávez-Suárez, María I Ortega-Vélez, Ana I Valenzuela-Quintanar, Marcia Galván-Portillo, Lizbeth López-Carrillo, Julián Esparza-Romero, María S Saucedo-Tamayo, María R Robles-Burgueño, Susana A Palma-Durán, María L Gutiérrez-Coronado, Melissa M Campa-Siqueiros, Patricia Grajeda-Cota, Graciela Caire-Juvera
There has been substantial interest in phytoestrogens, because of their potential effect in reducing cancer and heart disease risk. Measuring concentrations of phytoestrogens in urine is an alternative method for conducting epidemiological studies. Our objective was to evaluate the urinary excretion of phytoestrogens as biomarkers for dietary phytoestrogen intake in Mexican women. Participants were 100 healthy women from 25 to 80 years of age. A food frequency questionnaire (FFQ) and a 24 h recall were used to estimate habitual and recent intakes of isoflavones, lignans, flavonols, coumestrol, resveratrol, naringenin, and luteolin...
September 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28952266/-protective-effect-and-mechanism-of-total-lignans-from-tibetan-medicinal-herpetospermum-seeds-on-carbon-tetrachloride-induced-liver-fibrosis-in-rats
#14
Wei Liu, Xiao-Hong Fu, Si-Yuan Huang, Yan-Cheng Shi, Lin-Lin Shi, Jian Gu
This experiment was aimed to discuss the protective effect and mechanism of total lignans from Tibetan medicinal Herpetospermum seeds on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. Forty-eight male Sprague-Dawley rats were randomly divided into the blank control group (G1), model group (G2), total lignans high, middle and low dose groups (400,200, and 100 mg•kg⁻¹•d⁻¹)(G3/4/5) and the glycyrrhizin positive control group (25 mg•kg⁻¹•d⁻¹)(G6), n=8 in each group. The rats in blank group received normal feeding; the rats in model group, total lignans low, middle and high dose groups and glycyrrhizic group were subcutaneously in jected with 3 mL•kg⁻¹ olive oilsolution containing 40%CCl4 every two or three days for Eight weeks...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28951762/evaluation-of-antiulcer-and-cytotoxic-potential-of-the-leaf-flower-and-fruit-extracts-of-calotropis-procera-and-isolation-of-a-new-lignan-glycoside
#15
Areej Mohammad Al-Taweel, Shagufta Perveen, Ghada Ahmed Fawzy, Attiq Ur Rehman, Afsar Khan, Rashad Mehmood, Laila Mohamed Fadda
Calotropis procera is traditionally used for treating many diseases including ulcers and tumors. It was thus deemed of interest to investigate and compare the antiulcer and cytotoxic activities of C. procera leaf, flower, and fruit extracts in an attempt to verify its traditional uses. Phytochemical studies on the fruits, flowers, and leaves of C. procera, collected from the desert of Saudi Arabia, led to the isolation of one new lignan 7'-methoxy-3'-O-demethyl-tanegool-9-O-β-d-glucopyranoside and five known compounds from the flowers, four compounds from leaves, and a flavonoid glycoside and a lignan glycoside from the fruits...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28951214/arctigenin-represses-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-in-human-lung-cancer-cells
#16
Yanrui Xu, Zhiyuan Lou, Seong-Ho Lee
Arctigenin (ARC) is a lignan that is abundant in Asteraceae plants, which show anti-inflammatory and anti-cancer activities. The current study investigated whether ARC affects cancer progression and metastasis, focusing on EMT using invasive human non-small cell lung cancer (NSCLC) cells. No toxicity was observed in the cells treated with different doses of ARC (12-100 μM). The treatment of ARC repressed TGF-β-stimulated changes of metastatic morphology and cell invasion and migration. ARC inhibited TGF-β-induced phosphorylation and transcriptional activity of smad2/3, and expression of snail...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28948829/cytotoxic-lignans-from-the-barks-of-juglans-mandshurica
#17
Xiao-Ning Zhang, Ming Bai, Zhuo-Yang Cheng, Zhi-Guo Yu, Xiao-Xiao Huang
Phytochemical investigation of the barks of Juglans mandshurica Maxim led to the isolation, purification, and identification of one new lignan named Juglansol A (1), along with nine known compounds (2-10). Their structures were determined by the results of UV, IR, CD, HRESIMS, 1D, and 2D NMR spectroscopic analysis. Compounds 1-10 were evaluated for their cytotoxicities against A549, HepG2, Hep3B, Bcap-37, and MCF-7 cell lines. The results showed that compound 2 possessed stronger cytotoxicities against the tested tumor cell lines compared with positive control 5-fluorouracil...
September 26, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28947153/discovery-of-potential-antiausterity-agents-from-the-japanese-cypress-chamaecyparis-obtusa
#18
Dya Fita Dibwe, Sijia Sun, Jun-Ya Ueda, Chandrasekar Balachandran, Kinzo Matsumoto, Suresh Awale
The chloroform extract of the Japanese cypress Chamaecyparis obtusa was found to kill PANC-1 human pancreatic cancer cells preferentially in the nutrient-deprived medium without causing toxicity in the nutrient rich condition. Phytochemical investigation on this extract led to the isolation of a new sesquiterpene (1), together with the six sesquiterpenes (2-7) and a lignan (8). The isolated compounds were tested for their preferential cytotoxicity activity against five different human pancreatic cancer cell lines [PANC-1, MIA PaCa2, CAPAN-1, PSN-1, and KLM-1] by utilizing an antiausterity strategy...
September 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28943942/honokiol-inhibits-bladder-cancer-cell-invasion-through-repressing-src-3-expression-and-epithelial-mesenchymal-transition
#19
Lan Shen, Fang Zhang, Ruimin Huang, Jun Yan, Bing Shen
Urinary bladder cancer (UBC) is one of the most common urological cancer types. Muscle invasive bladder cancer possesses high propensity for metastasis with poor prognosis. Honokiol is a lignan isolated from Magnolia officinalis with high bioavailability and potent anticancer effects. The results of the present study demonstrated that honokiol significantly inhibited UBC cell migration and invasion in a dose-dependent manner compared with the vehicle-treated control group. In addition, honokiol treatment suppressed epithelial-mesenchymal transition by induction of E-cadherin and repression of N-cadherin...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28938521/beneficial-health-applications-and-medicinal-values-of-pedicularis-plants-a-review
#20
REVIEW
Mohd Iqbal Yatoo, Umesh Dimri, Arumugam Gopalakrishnan, Kumaragurubaran Karthik, Marappan Gopi, Rekha Khandia, Mani Saminathan, Archana Saxena, Mahmoud Alagawany, Mayada Ragab Farag, Ashok Munjal, Kuldeep Dhama
Pedicularis plants (Orobanchaceae), popularly known as lousewort, are found in Asia, Europe, and North America, and have been used in Sowa-Rigpa, the Himalayan art of healing and a traditional system of medicine for treating various ailments in humans. A comprehensive compilation on this valuable medicinal plant is not available, however. The present extensive review provides insight into the salient medicinal properties of Pedicularis plants with respect to various health issues and diseases. Our previous studies on Pedicularis plants from the Changthang region of Ladakh (India) and research advances leading to new developments in this field have prompted this review...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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