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https://www.readbyqxmd.com/read/28412932/isolation-of-enterococci-their-antimicrobial-susceptibility-patterns-and-associated-factors-among-patients-attending-at-the-university-of-gondar-teaching-hospital
#1
Amelework Yilema, Feleke Moges, Sisay Tadele, Mengistu Endris, Afework Kassu, Wondwossen Abebe, Getnet Ayalew
BACKGROUND: Enterococci become clinically important especially in immune compromised patients and important causes of nosocomial infections. Data on the prevalence, antimicrobial susceptibility patterns and associated factors of enterococci are scarce in Ethiopia. METHODS: A hospital based cross-sectional study was conducted at the University of Gondar Teaching Hospital from February 28, 2014 to May 1, 2014. Pretested structured questionnaire was used to collect socio-demographic data and possible associated factors of enterococci infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28405460/provision-of-straw-by-a-foraging-tower-effect-on-tail-biting-in-weaners-and-fattening-pigs
#2
Carolin Holling, Elisabeth Grosse Beilage, Beatriz Vidondo, Christina Nathues
BACKGROUND: Straw is one of the most effective rooting materials to reduce tail biting in pigs. A so-called foraging-tower (FT) provides only small quantities of straw compatible with liquid manure systems. The focus of the present study was on the effect of providing straw by FT in order to prevent tail biting in tail docked pigs. Four consecutive batches of 160 pigs, randomly divided into a straw (SG) and a control group (CG) were followed up from weaning to slaughter. RESULTS: Tail wounds (Score ≥ 2) were detected in 104 out of 12,032 single observations (SG n = 48; CG n = 56) in 9 pens (SG n = 4/32; CG n = 5/32) mainly focused on the fattening period of batch 2 due to a failure in the ventilation system...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/28404843/overactive-egfr-signaling-leads-to-increased-fibrosis-after-sars-cov-infection
#3
Thiagarajan Venkataraman, Christopher Coleman, Matthew Frieman
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidity and mortality in humans. After infection with SARS-CoV, the acute lung injury caused by the virus must be repaired to regain lung function. A dysregulation in this wound healing process leads to fibrosis. Many survivors of SARS-CoV infection develop pulmonary fibrosis (PF) with higher prevalence in older patients. Using mouse models of SARS-CoV pathogenesis, we have identified that the wound repair pathway, controlled by the Epidermal Growth Factor Receptor (EGFR) is critical to recovery from SARS-CoV induced tissue damage...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28401320/the-virulence-factors-of-group-a-streptococcus-strains-isolated-from-invasive-and-non-invasive-infections-in-polish-and-german-centres-2009-2011
#4
M Strus, P B Heczko, E Golińska, A Tomusiak, A Chmielarczyk, M Dorycka, M van der Linden, A Samet, A Piórkowska
Streptococcus pyogenes (GAS) is one of the major human pathogenic bacteria that cause a wide range of diseases. Currently, increased incidence of streptococcal invasive infections is observed worldwide. In this study, we focused on the prevalence of genes encoding superantigens and type M proteins in the population of GAS strains from invasive versus non-invasive infections. We tested 253 GAS strains: 48 strains from patients with invasive infections (18 from wound/deep skin localization, 30 from women in labour) and 205 strains from non-invasive forms (147 from common infections of the upper respiratory, 49 from the vagina of females with genital tract infections and 9 from non-invasive wound and superficial skin infections)...
April 11, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28393320/prevalence-and-ethnic-racial-disparities-in-the-distribution-of-pediatric-injuries-in-south-florida-implications-for-the-development-of-community-prevention-programs
#5
Carmen Ramos Irizarry, Patrick C Hardigan, Mark G Mc Kenney, Gretchen Holmes, Rudy Flores, Brenda Benson, Ascension M Torres
BACKGROUND: The state of Florida continues to report significant gender, ethnic and racial disparities in trauma incidence, access to care and outcomes in the adult population. Our objective was to assess pediatric injury profiles and ethnic/racial disparities of specific injuries in a Regional Trauma Center (TC) in South Florida. METHODS: Retrospective data from November 2011 to December 2015 were obtained from the Level 2 TC registry for children ≤21 years old...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28386280/bacterial-isolates-and-their-antimicrobial-susceptibility-patterns-of-wound-infections-among-inpatients-and-outpatients-attending-the-university-of-gondar-referral-hospital-northwest-ethiopia
#6
Aynalem Mohammed, Mengistu Endris Seid, Teklay Gebrecherkos, Moges Tiruneh, Feleke Moges
Background. The widespread uses of antibiotics, together with the length of time over which they have been available, have led to the emergence of resistant bacterial pathogens contributing to morbidity and mortality. This study was aimed to assess bacterial isolates and their drug susceptibility patterns from inpatients and outpatients with pus and/or wound discharge. Methods. A cross-sectional study was conducted at the University of Gondar Referral Hospital from March to May, 2014. Wound swab samples were collected from each study participant and inoculated into appropriate media...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28379054/nedd4-is-involved-in-acquisition-of-epithelial-mesenchymal-transition-in-cisplatin-resistant-nasopharyngeal-carcinoma-cells
#7
Shaoyan Feng, Guangwei Yang, Haidi Yang, Zibin Liang, Rongkai Zhang, Yunping Fan, Gehua Zhang
Nasopharyngeal carcinoma (NPC) is a highly invasive head-neck cancer derived from the nasopharyngeal epithelium, mainly prevalent in southern China and Southeast Asia. Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard administrations applied in the treatment of NPC. However, resistance to chemotherapeutic drugs has recently become more common, resulting in worse treatment outcome for NPC therapy. To elucidate the underlying molecular basis of drug resistance to DDP in NPC cells, we examined the morphocytology, cell motility and molecular changes in DDP-resistant NPC cells with respect to epithelial-mesenchymal transition (EMT) features...
April 5, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28370679/secreted-factors-from-equine-mesenchymal-stromal-cells-diminish-the-effects-of-tgf-%C3%AE-1-on-equine-dermal-fibroblasts-and-alter-the-phenotype-of-dermal-fibroblasts-isolated-from-cutaneous-fibroproliferative-wounds
#8
Rebecca M Harman, Ivanna V Bihun, Gerlinde R Van de Walle
The prevalence of cutaneous fibroproliferative disorders (CFPDs) is high and almost exclusively occurs in humans (keloids and hypertrophic scars) and horses (exuberant granulation tissue), making the horse a valuable translational model for studies on prevention and treatment of human CFPDs. CFPDs arise as a result of dysregulated wound healing characterized by persistently high levels of cytokines, such as transforming growth factor beta 1 (TGF-β1), that contribute to excessive extracellular matrix deposition, and the physical disorganization of dermal fibroblasts...
April 1, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28361041/decrease-of-staphylococcus-aureus-virulence-by-helcococcus-kunzii-in-a-caenorhabditis-elegans-model
#9
Christelle Ngba Essebe, Orane Visvikis, Marguerite Fines-Guyon, Anne Vergne, Vincent Cattoir, Alain Lecoustumier, Emmanuel Lemichez, Albert Sotto, Jean-Philippe Lavigne, Catherine Dunyach-Remy
Social bacterial interactions are considered essential in numerous infectious diseases, particularly in wounds. Foot ulcers are a common complication in diabetic patients and these ulcers become frequently infected. This infection is usually polymicrobial promoting cell-to-cell communications. Staphylococcus aureus is the most prevalent pathogen isolated. Its association with Helcococcus kunzii, commensal Gram-positive cocci, is frequently described. The aim of this study was to assess the impact of co-infection on virulence of both H...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28358935/comparison-of-neurovascular-characteristics-of-facial-skin-in-patients-after-primary-and-revision-rhytidectomies
#10
Farhad Ardeshirpour, Elisabeth Hurliman, Gwen Wendelschafer-Crabb, Brian McAdams, Peter A Hilger, William R Kennedy, Amy Anne D Lassig, Michael J Brenner
Importance: Wound healing influences both the cosmetic and functional outcomes of facial surgery. Study of cutaneous innervation may afford insight into patients' preoperative wound healing potential and aid in their selection of appropriate surgical procedures. Objective: To present the quantitative and qualitative differences of epidermal nerve fibers (ENFs), neurotransmitters, vasculature, and mast cells in facial skin among patients after primary and revision rhytidectomies...
March 30, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28358636/seroprevalence-of-heartworm-infection-risk-factors-for-seropositivity-and-frequency-of-prescribing-heartworm-preventives-for-cats-in-the-united-states-and-canada
#11
Julie K Levy, Amie N Burling, Michael M Crandall, Sylvia J Tucker, Erin G Wood, Jessie D Foster
OBJECTIVE To determine the seroprevalence of heartworm infection, risk factors for seropositivity, and frequency of prescribing heartworm preventives for cats. DESIGN Prospective cross-sectional study. ANIMALS 34,975 cats from 1,353 veterinary clinics (n = 26,707) and 125 animal shelters (8,268) in the United States and Canada. PROCEDURES Blood samples were collected from all cats and tested with a point-of-care ELISA for Dirofilaria immitis antigen, FeLV antigen, and FIV antibody. Results were compared among geographic regions and various cat groupings...
April 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28357176/novel-and-emerging-therapies-in-the-treatment-of-recessive-dystrophic-epidermolysis-bullosa
#12
REVIEW
Ellie Rashidghamat, John A McGrath
Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of inherited blistering diseases that affects ∼ 500,000 people worldwide. Clinically, individuals with EB have fragile skin and are susceptible to blistering following minimal trauma, with mucous membrane and other organ involvement in some subtypes. Within the spectrum of EB, ∼ 5% of affected individuals have the clinically more severe recessive dystrophic (RDEB) variant with a prevalence of 8 per one million of the population...
February 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28357172/the-use-of-whatsapp-smartphone-messaging-improves-communication-efficiency-within-an-orthopaedic-surgery-team
#13
Prasad Ellanti, Andrew Moriarty, Fionn Coughlan, Thomas McCarthy
INTRODUCTION: Effective and timely communication is important for any surgical specialty to function. The use of smartphones is prevalent amongst doctors. Numerous smartphone applications offer the potential for fast and cost-effective communication. WhatsApp is a commonly used application that is free, easy to use, and capable of text and multimedia messaging. We report on the use of WhatsApp over a six month period in our unit. MATERIALS AND METHODS: WhatsApp communication between non-consultant members of an orthopaedic team over a six-month period was analysed...
February 18, 2017: Curēus
https://www.readbyqxmd.com/read/28355466/invasive-mould-infections-in-the-icu-setting-complexities-and-solutions
#14
Matteo Bassetti, Emilio Bouza
Infections caused by filamentous fungi represent a major burden in the ICU. Invasive aspergillosis is emerging in non-neutropenic individuals with predisposing conditions, e.g. corticosteroid treatment, chronic obstructive pulmonary disease, liver cirrhosis, solid organ cancer, HIV infection and transplantation. Diagnosis is challenging because the signs and symptoms are non-specific, and initiation of additional diagnostic examinations is often delayed because clinical suspicion is low. Isolation of an Aspergillus species from the respiratory tract in critically ill patients, and tests such as serum galactomannan, bronchoalveolar lavage 1-3-β-d-glucan and specific PCR should be interpreted with caution...
March 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28351292/youth-self-harm-in-low-and-middle-income-countries-systematic-review-of-the-risk-and-protective-factors
#15
Shilpa Aggarwal, George Patton, Nicola Reavley, Shreenivas A Sreenivasan, Michael Berk
BACKGROUND: Self-harm (defined here as an act of intentionally causing harm to own self, irrespective of the type, motive or suicidal intent) is one of the strongest antecedents of suicide in youth. While there have been a number of studies of youth self-harm in low- and middle-income countries (LMICs), there is currently no systematic review of studies of prevalence rates and risk and protective factors. AIM: To systematically review the evidence relating to the prevalence rates and forms of self-harm in youth in LMICs and its relationship to family economic status, family functioning, relationship with the peer group, social relationships and academic performance...
March 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28344815/occupational-exposure-to-sharps-injury-among-healthcare-providers-in-ethiopia-regional-hospitals
#16
Nigussie Tadesse Sharew, Getaneh Baye Mulu, Tesfa Dejenie Habtewold, Kefyalew Dagne Gizachew
BACKGROUND: Sharps injury is a penetrating stab wound from a needle, scalpel, or another sharp object that may result in exposure to blood or other body fluids. According to World Health Organization pooled estimate, the annual incidence of sharps injury in Africa was ranged from 2.10 to 4.68 per person per year, but research data in Ethiopia is limited. The aim of the study was to investigate sharps injury prevalence and associated risk factors. METHODS: Institution based cross-sectional study was conducted with 200 healthcare providers (HCP) in Northeast Ethiopia...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28342704/trends-in-the-presentation-surgical-treatment-and-outcomes-of-tethered-cord-syndrome-a-nationwide-study-from-2001-to-2010
#17
Cyrus M Jalai, Charles Wang, Bryan J Marascalchi, Samantha R Horn, Gregory W Poorman, Olivia J Bono, Anthony K Frempong-Boadu, Peter G Passias
OBJECTIVE: This is a nationwide query into surgical management techniques for tethered cord syndrome, focusing on patient demographic, hospital characteristics, and treatment outcomes. Our hypothesis is that detethering vs. fusion for TCS results in different in-hospital complications. MATERIALS AND METHODS: Retrospective review of the Nationwide Inpatient Sample 2001-2010. Inclusion: TCS discharges undergoing detethering or fusion. Sub-analysis compared TCS cases by age (pediatric [≤9years] vs...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28339182/widespread-and-indiscriminate-nanosilver-use-genuine-potential-for-microbial-resistance
#18
Cindy Gunawan, Christopher P Marquis, Rose Amal, Georgios A Sotiriou, Scott A Rice, Elizabeth J Harry
In this era of increasing antibiotic resistance, the use of alternative antimicrobials such as silver has become more widespread. Superior antimicrobial activity has been provided through fabrication of silver nanoparticles or nanosilver (NAg), which imparts cytotoxic actions distinct from those of bulk silver. In the wake of the recent discoveries of bacterial resistance to NAg and its rising incorporation in medical and consumer goods such as wound dressings and dietary supplements, we argue that there is an urgent need to monitor the prevalence and spread of NAg microbial resistance...
March 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28328647/pressure-injury-in-a-community-population-a-descriptive-study
#19
Lisa Q Corbett, Marjorie Funk, Gilbert Fortunato, David M OʼSullivan
PURPOSE: The purpose of this study was to describe present-on-admission pressure injuries (POA-PIs) in community-dwelling adults admitted to acute care. The specific aims of the study were to (1) measure the prevalence of POA-PIs during a 1-year period; (2) determine prehospital location of patients with POA-PIs; and (3) describe demographics, pressure injury (PI) characteristics, risk factors, and posthospital outcome of community-dwelling adults with PIs admitted to hospital. DESIGN: Retrospective descriptive study...
March 21, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28318554/decubitus-ulcers-in-patients-undergoing-vascular-operations-do-not-influence-mortality-but-affect-resource-utilization
#20
J Hunter Mehaffey, Amani D Politano, Castigliano M Bhamidipati, Margaret C Tracci, Kenneth J Cherry, John A Kern, Irving L Kron, Gilbert R Upchurch
BACKGROUND: While it is anticipated that decubitus ulcers are detrimental to outcomes after vascular operations, the contemporary influence of perioperative decubitus ulcers in vascular surgery remains unknown. METHODS: Using the National Impatient Survey, all adult patients who underwent vascular operation were selected. Patients were stratified by the presence or absence (non-decubitus ulcers) of decubitus ulcer. Case-mix adjusted hierarchical mixed-models examined in-hospital mortality, the occurrence of any complication, and discharge disposition...
March 17, 2017: Surgery
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