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https://www.readbyqxmd.com/read/29453386/anti-fibrotic-effects-of-cxcr4-targeting-i-body-ad-114-in-preclinical-models-of-pulmonary-fibrosis
#1
K Griffiths, D M Habiel, J Jaffar, U Binder, W G Darby, C G Hosking, A Skerra, G P Westall, C M Hogaboam, M Foley
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease that is prevalent in individuals >50 years of age, with a median survival of 3-5 years and limited therapeutic options. The disease is characterized by collagen deposition and remodeling of the lung parenchyma in a process that is thought to be driven by collagen-expressing immune and structural cells. The G-protein coupled C-X-C chemokine receptor 4, CXCR4, is a candidate therapeutic target for IPF owing to its role in the recruitment of CXCR4 + fibrocytes from the bone marrow to fibrotic lung tissue and its increased expression levels by structural cells in fibrotic lung tissue...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447490/combined-effects-of-artificial-dermis-and-vascular-endothelial-growth-factor-concentration-gradient-on-wound-healing-in-diabetic-porcine-model
#2
Hok Yin Tsui, You Chen Liu, Xin Yan, Yue Lin, Ye Xu, Qian Tan
Wounds in patients with diabetes mellitus are one of the most prevalent impaired wounds in the world. Vascular endothelial growth factor (VEGF) is one of the most important proangiogenic mediators. Artificial dermal (AD) such as Pelnac ® has been shown, in humans and animal models, a great therapeutic potential in full-thickness skin wounds. We attempt to promote the wound healing in diabetic porcine models through combined use of AD and constant concentration of VEGF or VEGF concentration gradient. We created full-thickness excisional wounds in diabetic animal models...
February 15, 2018: Growth Factors
https://www.readbyqxmd.com/read/29443741/research-progress-of-asymptomatic-bacteriuria-before-arthroplasty-a-systematic-review
#3
Qingyu Zhang, Lihua Liu, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li
BACKGROUND: A high prevalence of asymptomatic bacteriuria exists in patients prior to arthroplasty, and urinary tract infection is considered to be a source of postoperative superficial wound and prosthetic joint infections. There is no consensus whether to screen for and treat asymptomatic bacteriuria before arthroplasty. OBJECTIVE: To summarize the association between asymptomatic bacteriuria and complications after arthroplasty and to evaluate the clinical benefits of treating asymptomatic bacteriuria prior to arthroplasty...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29438821/molecular-characterisation-of-esbl-producing-gram-negative-bacterial-isolates-from-surgical-wounds-of-patients-at-a-hospital-in-north-central-nigeria
#4
Ahmed Olowo-Okere, Yakubu Kokori Enevene Ibrahim, Busayo Olalekan Olayinka
OBJECTIVE: This study aimed to characterize ESBL-producing Gram-negative bacterial isolates from patients with surgical site infections (SSIs) at a tertiary healthcare facility in Abuja, Nigeria. METHOD: Consecutive, non-duplicate, wound swabs were collected, over three months period, from wounds of patients who had SSI and cultured appropriately. Bacterial isolates were identified using rapid identification kits. Modified disc diffusion method was used for antibiotics susceptibility testing and the phenotypic ESBL activity of the isolates was determined using the Double Discs Synergy Test (DDST)...
February 10, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29428241/ethnomedical-uses-and-pharmacological-activities-of-most-prevalent-species-of-genus-piper-in-panama-a-review
#5
REVIEW
Armando A Durant-Archibold, Ana I Santana, Mahabir P Gupta
ETHNOPHARMACOGICAL RELEVANCE: Piperaceae is the fifth largest family of plants in Panama. This review focuses on the ethnomedical uses of the most prevalent Panamanian species and biological activities of their extracts and/or constituents both in Panama and worldwide. Many species have a plethora of ethnomedical uses such as antibacterial, antifungal, anti-inflammatory, anticancer, antidiabetic, anti-Helicobacter pylori, antiulcer, antiprotozoal, estrogenic, insecticidal, local anesthetic, diuretic, and for women's health conditions...
February 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29425335/wounded-healers-a-multistate-study-of-licensed-social-workers-behavioral-health-problems
#6
Shulamith Lala Ashenberg Straussner, Evan Senreich, Jeffrey T Steen
Studies indicate that helping professionals are disproportionately affected by behavioral health problems. Among social workers, the nature and scope of these problems are understudied. This article reports the findings of a 2015 survey of 6,112 licensed social workers in 13 states regarding their problems with mental health; alcohol, tobacco, and other drugs; and gambling. To ascertain whether these problems preceded or developed during their social work careers, the periods of time when these issues were experienced were identified...
February 7, 2018: Social Work
https://www.readbyqxmd.com/read/29407239/seroprevalence-and-risk-factor-analysis-of-human-leptospirosis-in-distinct-climatic-regions-of-pakistan
#7
Muhammad Luqman Sohail, Muhammad Sarwar Khan, Muhammad Ijaz, Omer Naseer, Zahida Fatima, Abdullah Saghir Ahmad, Waqas Ahmad
Leptospirosis is a worldwide emerging infectious disease of zoonotic importance and large epidemics and epizootics have been reported all over the globe. A cross survey study was conducted to estimate seroprevalence of human leptospirosis in climatically distinct regions of Pakistan and to identify the risk factors associated with the disease. Blood samples from 360 humans were collected through convenient sampling, 120 from each of three study areas. Serological testing was performed using ELISA kit as per manufacturer's recommendations...
January 30, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29407236/drug-resistance-profile-and-molecular-characterization-of-extended-spectrum-beta-lactamase-es%C3%AE-l-producing-pseudomonas-aeruginosa-isolated-from-burn-wound-infections-essential-oils-and-their-potential-for-utilization
#8
Wagih A El-Shouny, Sameh S Ali, Jianzhong Sun, Sara M Samy, Asmaa Ali
OBJECTIVES: Pseudomonas aeruginosa producing extended spectrum β-lactamase (ESβL) enzyme had the ability for antimicrobial resistance mechanisms and its multidrug-resistant (MDR) phenotype, has been increasingly reported as a major clinical concern worldwide. The aim of this study was to (i) characterize ESβL-producing MDR P. aeruginosa isolated from burn wound infections phenotypically and molecularly, (ii) evaluate the antibacterial activity of some essential oils (EOs) against selected ESβL-producing drug resistant P...
February 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29406299/a-qualitative-study-to-explore-the-impact-of-simulating-extreme-obesity-on-health-care-professionals-attitudes-and-perceptions
#9
Caz Hales, Lesley Gray, Lynne Russell, Carol MacDonald
Extremely obese patients pose significant challenges for those who strive to provide care. The prevalence and consequences of weight bias and stigma in health care have been well documented, but research on how to reduce weight bias and stigma is limited. To assess the impact of simulating obesity on the attitudes and perceptions of health professionals toward extreme obesity, a qualitative study involving 6 registered nurses and 1 registered physiotherapist was conducted between November 2015 and May 2016...
January 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29405827/polymicrobial-infections-do-bacteria-behave-differently-depending-on-their-neighbours
#10
Iñigo Lasa, Cristina Solano
Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected to target the most relevant pathogen, with no consideration of the consequences that the presence of other bacterial species may have in the pathogenicity and response to antimicrobial agents. In this issue of Virulence, Garcia-Perez et al. 10 applied replica plating of used wound dressings to assess the topography of distinct S...
February 6, 2018: Virulence
https://www.readbyqxmd.com/read/29396882/the-impact-of-care-practices-and-health-demographics-on-the-prevalence-of-skin-tears-and-pressure-injuries-in-aged-care
#11
Rachel E Brimelow, Judy A Wollin
AIMS: To determine whether differences in care practices and demographics between two long-term aged care facilities affected the incidence of residents' skin wounds. METHODS: A retrospective analysis of care plans and clinical outcomes was conducted for a six month period in 2016 at two aged care facilities, N=39 Home 1 and N=45 Home 2. Skin tears, pressure injuries and usual care practices and associated health demographics were recorded. RESULTS: Over the six month period, 84 residents were found to have a total of 206 aged care acquired skin wounds (skin tears, pressure injuries, haematomas, rashes, infections)...
February 3, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29394924/spousal-age-difference-and-associated-predictors-of-intimate-partner-violence-in-nigeria
#12
Ayo Stephen Adebowale
BACKGROUND: The growth in Intimate Partner Violence (IPV) cases among couples in Nigeria has been significant in recent years. Victims, which are often females, face numerous health challenges, including early death. I examined the linkages between spousal age differences and IPV in Nigeria. METHOD: The couples recode data section of the 2013 Nigeria Demographic Health and Survey was used (n = 6765). Intimate partner violence was measured using 13-item questions...
February 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29391370/codifi-concordance-in-diabetic-foot-ulcer-infection-a-cross-sectional-study-of-wound-swab-versus-tissue-sampling-in-infected-diabetic-foot-ulcers-in-england
#13
Andrea Nelson, Alexandra Wright-Hughes, Michael Ross Backhouse, Benjamin A Lipsky, Jane Nixon, Moninder S Bhogal, Catherine Reynolds, Sarah Brown
OBJECTIVE: To determine the extent of agreement and patterns of disagreement between wound swab and tissue samples in patients with an infected diabetic foot ulcer (DFU). DESIGN: Multicentre, prospective, cross-sectional study. SETTING: Primary and secondary care foot ulcer/diabetic outpatient clinics and hospital wards across England. PARTICIPANTS: Inclusion criteria: consenting patients aged ≥18 years; diabetes mellitus; suspected infected DFU...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29388188/the-paracelsus-score-a-novel-diagnostic-tool-for-pyoderma-gangrenosum
#14
F Jockenhöfer, U Wollina, K A Salva, S Benson, J Dissemond
BACKGROUND: The lack of objective diagnostic criteria renders pyoderma gangrenosum (PG) a diagnosis of exclusion. The diagnostic approaches proposed to date have not been systematically evaluated. Thus, PG remains a challenging and frequently misdiagnosed disorder. OBJECTIVES: To develop and assess a comprehensive yet clinically practicable as well as sensitive diagnostic scoring system for PG. METHODS: Clinical history and images of a total of 60 subjects with previously confirmed PG located on the lower extremity as well as a control cohort of 50 patients with venous leg ulcers were retrospectively evaluated by expert teams at two tertiary dermatological centres specializing in wound care using a newly developed diagnostic scoring system composed of ten criteria...
February 1, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29369452/accuracy-of-computed-tomography-in-diagnosis-of-intra-abdominal-injuries-in-stable-patients-with-anterior-abdominal-stab-wounds-a-systematic-review-and-meta-analysis
#15
Bonny J Baron, Roshanak Benabbas, Casey Kohler, Carina Biggs, Valery Roudnitsky, Lorenzo Paladino, Richard Sinert
BACKGROUND: Work-up for patients presenting to the Emergency Department (ED) following an anterior abdominal stab wound (AASW) has been debated since the 1960s. Experts agree that patients with peritonitis, evisceration, or hemodynamic instability should undergo immediate laparotomy (LAP), however, workup of stable, asymptomatic or non-peritoneal, patients is not clearly defined. OBJECTIVES: To evaluate the accuracy of computed tomography of abdomen and pelvis (CTAP) for diagnosis of intra-abdominal injuries requiring Therapeutic Laparotomy (THER-LAP) in ED patients with AASW...
January 25, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29367110/antidotal-or-protective-effects-of-curcuma-longa-turmeric-and-its-active-ingredient-curcumin-against-natural-and-chemical-toxicities-a-review
#16
REVIEW
Azar Hosseini, Hossein Hosseinzadeh
Curcuma longa is a rhizomatous perennial herb that belongs to the family Zingiberaceae, native to South Asia and is commonly known as turmeric. It is used as herbal remedy due to the prevalent belief that the plant has medical properties. C. longa possesses different effects such as antioxidant, anti-tumor, antimicrobial, anti-inflammatory, wound healing, and gastroprotective activities. The recent studies have shown that C. longa and curcumin, its important active ingredient, have protective effects against toxic agents...
January 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29366615/the-evaluation-and-management-of-toxic-shock-syndrome-in-the-emergency-department-a-review-of-the-literature
#17
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Toxic shock syndrome (TSS) is a severe, toxin-mediated illness that can mimic several other diseases and is lethal if not recognized and treated appropriately. OBJECTIVE: This review provides an emergency medicine evidence-based summary of the current evaluation and treatment of TSS. DISCUSSION: The most common etiologic agents are Staphylococcus aureus and Streptococcus pyogenes. Sources of TSS include postsurgical wounds, postpartum, postabortion, burns, soft tissue injuries, pharyngitis, and focal infections...
January 20, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29357913/screening-of-methicillin-resistant-staphylococcus-aureus-nasal-colonization-among-elective-surgery-patients-in-referral-hospital-in-indonesia
#18
Erni J Nelwan, Robert Sinto, Decy Subekti, Randy Adiwinata, Lia Waslia, Tonny Loho, Dodi Safari, Djoko Widodo
OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) colonization is associated with serious surgical site infection in high-risk patients. High prevalence of MRSA colonization was reported in many settings, nonetheless local data is required. The purpose of this study is to identify the prevalence and risk factor of MRSA nasal carriage in adult patients in National Referral Hospital in Indonesia before underwent elective surgical procedure. RESULTS: From 384 patients, 16...
January 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29340463/prevalence-of-and-risk-factors-associated-with-the-presence-of-staphylococcus-aureus-in-the-chronic-wounds-of-patients-treated-in-primary-health-care-settings-in-brazil
#19
Eliane Patricia Lino Pereira-Franchi, Maria Rachel Nogueira Barreira, Natália de Sousa Lima Moreira da Costa, Carlos Magno Castelo Branco Fortaleza, Maria de Lourdes Ribeiro de Souza da Cunha
INTRODUCTION: Wounds can be colonized by methicillin-resistant Staphylococcus aureus (MRSA). METHODS: We evaluated the prevalence of S. aureus and MRSA in the wounds of patients treated at Basic Health Units in Brazil and identified risk factors associated with their presence. RESULTS: The prevalence rates of S. aureus and MRSA were 51.5% and 8.7%, respectively. There was a correlation between the presence of S. aureus in wounds and nostrils (p<0...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29331010/implants-for-extracapsular-neck-of-femur-fracture-dynamic-hip-screw-versus-intramedullary-nailing
#20
Faisal Farooq Butt, Adnan Shabbair Hussain, Ahmed Mushtaq Khan, Maria Sultan
Neck of femur fractures are the most prevalent type of injury in elderly trauma patients. Both intra and extra capsular type of fractures are equally distributed in the given population. Traditionally, Extra capsular fractures are fixed with Dynamic Hip screw or Intra medullary nailing based on the type of fracture. NICE (National Institute of Clinical Excellence) recommends fixing 31-A1 and 31-A2 fractures with DHS (Dynamic Hip Screw) whereas AO recommends fixing 31-A1 with DHS and 31-A2.1 subtype with DHS and 31-A2...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
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