keyword
https://read.qxmd.com/read/38535843/characterization-of-the-pro-inflammatory-and-pruritogenic-transcriptome-in-skin-lesions-of-the-experimental-canine-atopic-acute-ige-mediated-late-phase-reactions-model-and-correlation-to-acute-skin-lesions-of-human-atopic-dermatitis
#1
JOURNAL ARTICLE
Amanda Blubaugh, Kathleen Hoover, Sujung Jun Kim, Jonathan E Fogle, Fatoumata B Sow, Frane Banovic
Intradermal injection of anti-immunoglobulin E (IgE) antibodies in dogs grossly and histologically resemble naturally occurring atopic dermatitis (AD). However, the activated inflammatory and pruritic pathways have not been characterized. The objectives of this study were to characterize the inflammatory transcriptome of experimental acute canine IgE-induced lesions and to determine how these correlate to the transcriptome of naturally occurring human and canine acute atopic dermatitis. Biopsies were collected at 6 and 24 h after intradermal injections of anticanine-IgE antibodies to eight healthy male castrated Beagles; healthy and saline-injected skin served as controls...
March 1, 2024: Veterinary Sciences
https://read.qxmd.com/read/38534759/the-beneficial-role-of-lactobacillus-paracasei-subsp-paracasei-ntu-101-in-the-prevention-of-atopic-dermatitis
#2
JOURNAL ARTICLE
Chin-Feng Liu, Tsung-Wei Shih, Chun-Lin Lee, Tzu-Ming Pan
Atopic dermatitis (AD) is a recurrent allergic disease characterized by symptoms such as itching, redness, swelling, dryness, scaling skin, inflammation, and tissue damage. The underlying pathogenesis of AD remains unclear. Steroid drugs are commonly used in the clinical treatment of AD; however, their long-term use may lead to associated complications. Numerous studies have indicated that probiotics could modulate the immune system, enhance immune function, or suppress excessive immune responses. In this study, Lactobacillus paracasei subsp...
March 9, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533495/imidazole-propionate-ameliorates-atopic-dermatitis-like-skin-lesions-by-inhibiting-mitochondrial-ros-and-mtorc2
#3
JOURNAL ARTICLE
Ha Eun Kim, Jong Yeong Lee, Dong-Hoon Yoo, Hyo-Hyun Park, Eun-Ju Choi, Kyung-Hwa Nam, Jin Park, Jin Kyeong Choi
BACKGROUND: Imidazole propionate (IMP) is a histidine metabolite produced by some gut microorganisms in the human colon. Increased levels of IMP are associated with intestinal inflammation and the development and progression of cardiovascular disease and diabetes. However, the anti-inflammatory activity of IMP has not been investigated. This study aimed to elucidate the role of IMP in treating atopic dermatitis (AD). METHODS: To understand how IMP mediates immunosuppression in AD, IMP was intraperitoneally injected into a Dermatophagoides farinae extract (DFE)/1-chloro-2,4 dinitrochlorobenzene (DNCB)-induced AD-like skin lesions mouse model...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#4
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38488697/undaria-pinnatifida-ameliorates-nasal-inflammation-by-inhibiting-eosinophil-and-mast-cell-activation-and-modulating-the-nf-%C3%AE%C2%BAb-mapks-signaling-pathway
#5
JOURNAL ARTICLE
Zhen Nan Yu, Yan Jing Fan, Thi Van Nguyen, Chun Hua Piao, Byung-Hoo Lee, So-Young Lee, Hee Soon Shin, Chang Ho Song, Ok Hee Chai
BACKGROUND: Allergic rhinitis (AR) is the most prevalent form of atopic disease. Undaria pinnatifida has potent antioxidative, antidiabetic, and anti-inflammatory properties. AIMS: We investigated the immunomodulatory effect of Undaria pinnatifida extract (UPE) on allergic inflammation in an AR mouse model. MATERIALS & METHODS: Mice were sensitized and intranasally challenged with ovalbumin (OVA), and the Th1/Th2 and Th17/Treg-related cytokines and histopathology were exanimated after UPE treatments...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38414407/blockade-of-exosome-release-alleviates-the-hypersensitive-reaction-by-influencing-the-t-helper-cell-population-in-cow-s-milk-allergic-mice
#6
JOURNAL ARTICLE
Xin Ma, Jiaheng Xia, Jin Yuan, Xuanyi Meng, Hongbing Chen, Xin Li
The aim of this work was to evaluate the ameliorative effects of exosome biogenesis in cow's milk allergy (CMA) response. In this context, BALB/c mice were systemically sensitized with cow's milk proteins plus an aluminum adjuvant to induce CMA. The inhibitor GW4869 of exosome biogenesis was added before sensitization and then the anaphylactic reactions were evaluated both in vivo (clinical score and body temperature) and in vitro (serum histamine, allergen-specific antibodies, cytokines by ELISA and cell analysis by flow cytometry) to explore the role of exosomes in the development of CMA...
February 28, 2024: Food & Function
https://read.qxmd.com/read/38409842/down-regulation-of-insr-restores-th17-treg-immune-balance-and-alleviates-airway-hyperviscosity-in-asthmatic-mice-via-inactivation-of-stat3-pathway
#7
JOURNAL ARTICLE
Xuanlin Jin, Jin Wang
BACKGROUND: Allergic asthma (AA) is a prevalent chronic airway inflammation disease. In this study, this study aims to investigate the biological functions and potential regulatory mechanisms of the insulin receptor ( INSR ) in the progression of AA. METHODS: BALB/c mice (n = 48) were randomly divided into the following groups: control group, AA group, AA+Lentivirus (Lv)-vector short hairpin RNA (shRNA) group, AA+Lv-vector group, AA+Lv- INSR shRNA group, and AA+Lv- INSR group...
February 2024: Discovery Medicine
https://read.qxmd.com/read/38376812/n-acetyl-cysteine-augments-adipose-tissue-derived-stem-cell-efficacy-on-inflammatory-markers-and-regulatory-t-cell-system-balance-in-an-allergic-asthma-model
#8
JOURNAL ARTICLE
Maryam Radan, Farhad Abol Nejadian, Vahid Bayati, Ali Asghar Hemmati, Khojasteh Hoseinynejad, Seyyed Ali Mard
Background Allergic asthma is a destructive inflammatory process in the respiratory system. The anti-inflammatory and antioxidant effects of N-acetylcysteine (NAC) have been reported in patients with obstructive pulmonary disease. On the other hand, several studies have shown the modulatory effects of mesenchymal stem cells on the immune system and inflammatory responses. Accordingly, the purpose of the current study was to evaluate the effect of administration of adipose tissue-derived stem cells (ADSCs) plus NAC on regulatory T cell system balance in an allergic asthma model...
February 20, 2024: Journal of Asthma
https://read.qxmd.com/read/38330800/serum-iga-contributes-to-the-comprehension-of-anisakis-simplex-associated-chronic-urticaria
#9
JOURNAL ARTICLE
Juan González-Fernández, Laura Ullate, Virginia Fernández-Fígares, Marta Rodero, Alvaro Daschner, Carmen Cuéllar
The phenotype of allergic diseases associated with Anisakis determines the pattern of cytokines related to antibody production. However, the role of serum IgA and the immunomodulatory mechanisms exerted by active infection of L3 or passive mucosal contact with A. simplex specific antigens has not been studied before. We measured serum cytokine by flow cytometry (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, IL-17A, TGF-β1) and antibody levels (IgE, IgG4, IgA) by ELISA against total and excretory-secretory (ES) antigens, Ani s 3,and the group of major allergens Ani s 1, Ani s 7, and Ani s 13 in sera from 10 patients with gastro-allergic anisakiasis (GAA), 11 Anisakis sensitization associated chronic urticaria (CU+) as well as 17 non-Anisakis-sensitized patients with chronic urticaria (CU-), compared with the urticaria control group (18 subjects)...
February 7, 2024: International Immunopharmacology
https://read.qxmd.com/read/38169056/peripheral-blood-mononuclear-cell-transcriptome-profile-in-a-clinical-trial-with-subcutaneous-grass-pollen-allergoid-immunotherapy
#10
JOURNAL ARTICLE
Sviatlana Starchenka, Kemi Oluwayi, Matthew Heath, Oliver Armfield, Mohamed Shamji, Janice Layhadi, Katarzyna Lis, Lisa Cadavez, Olesya Rusyn, Murray Skinner, Pieter-Jan De Kam
INTRODUCTION: Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in allergic airway diseases. Underlying immunological mechanisms and candidate biomarkers, which may be translated into predictive/surrogate measures of clinical efficacy, remain an active area of research. The aim of this study was to evaluate Pollinex Quattro (PQ) Grass AIT induced immunomodulatory mechanisms, based on transcriptome profiling of peripheral blood mononuclear cells. METHODS: 119 subjects with grass pollen induced seasonal allergic rhinitis (SAR) were randomized in a 2:2:1:1 ratio to receive a cumulative dose of PQ Grass as a conventional or extended pre-seasonal regimen, placebo, or placebo with MicroCrystalline Tyrosine...
January 2, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38111539/lipocalin-2-lcn2-knockdown-regulates-treg-th17-balance-to-improve-asthma-in-mice
#11
JOURNAL ARTICLE
Le Xu, Minkang Shi
PURPOSE: Asthma substantially affects the quality of life and health of children. Lipocalin 2 (LCN2) is an immune-related protein, which is predicted to be highly expressed in asthma. Here, we investigated the role of LCN2 in ovalbumin (OVA)-induced asthma mouse model. METHODS: We knocked down LCN2 in an asthma mouse model and performed histopathological analysis using hematoxylin and eosin (H&E) staining assay. Differentiated cells were assessed using Diff-Quick staining assay...
2023: Journal of Asthma and Allergy
https://read.qxmd.com/read/38091784/covalent-conjugation-with-polyphenol-reduced-the-sensitization-of-walnut-and-ameliorated-allergy-by-enhancing-intestinal-epithelial-barrier-in-mice
#12
JOURNAL ARTICLE
Jing Ma, Pengyan Tong, Qiwen Chen, Jing Liu, Huzhong Li, Fangyu Long
In order to reduce the sensitization of walnut protein (WP), the effects of the interaction between WP and (-)-Epigallocatechin gallate (EGCG), quercetin, trans-ferulic acid, and resveratrol were investigated. Covalent and non-covalent conjugations were compared. The results suggested that covalent conjugation reduced the free amino acid content, sulfhydryl content, and surface hydrophobicity. When compared to non-covalent conjugation, covalent modification showed a lower IgE binding capacity, accompanied by changes in protein conformation...
December 9, 2023: Food Chemistry
https://read.qxmd.com/read/38059621/effect-of-intralymphatic-allergen-specific-immunotherapy-on-house-dust-mite-in-a-murine-model-of-allergic-rhinitis
#13
JOURNAL ARTICLE
Joo Hyun Jung, Kyeong Ah Kim, Yun Sook Choi, Seon Tae Kim
BACKGROUND: Intralymphatic immunotherapy (ILIT) is a promising alternative for the treatment of patients with allergic rhinitis, providing similar therapeutic efficacy to conventional allergen-specific immunotherapy (AIT). However, the allergic mechanism of ILIT is not completely known. AIM: The aim of this study was to determine the efficacy of ILIT in a house dust mite (HDM) mouse model of allergic rhinitis. METHODS: BALB/c mice were divided into four groups: G1, control without allergy; G2, allergy sensitized with HDM; G3, allergy with ILIT (starting with HDM 1...
December 7, 2023: Acta Oto-laryngologica
https://read.qxmd.com/read/38016605/wljp-025p-a-homogeneous-lonicera-japonica-polysaccharide-attenuates-atopic-dermatitis-by-regulating-the-mapk-nf%C3%AE%C2%BAb-ap-1-axis-via-act1
#14
JOURNAL ARTICLE
Tao Zhang, Xiuming Rao, Shiyuan Song, Keke Tian, Yuqi Wang, Chaoyu Wang, Xinyu Bai, Ping Liu
Atopic dermatitis (AD) is usually treated with steroids, but long-term use is not an effective cure because side effects and disease aggravation. Therefore, more effective and safer treatments are needed. Using dexamethasone as the positive control, the mechanism of action of water-extracted homogeneous honeysuckle Lonicera japonica polysaccharide (WLJP-025p) to alleviate AD was studied. Mice were administered 2,4-dinitrochlorobenzene in their bare back and right ear to mimic an AD model. The efficacy of WLJP-025p in AD was assessed by measuring right ear thickness and skin lesion scores, pathological observation (haematoxylin-eosin and toluidine blue staining), and serum IgE and IL-1β concentrations...
November 26, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38008215/diversity-of-atopic-dermatitis-and-selection-of-immune-targets
#15
REVIEW
Camille Rothenberg-Lausell, Jonathan Bar, Ester Del Duca, Emma Guttman-Yassky
Atopic dermatitis (AD) is a heterogeneous immune-mediated skin disorder affecting people of all ages and ethnicities. Despite the development of targeted therapeutics such as biologics and JAK inhibitors, attaining complete clinical efficacy remains difficult. This therapeutic challenge may be attributed to the complex pathogenesis of AD. While the Th2 axis has been extensively studied, recent advancements have started to reveal the involvement of additional immune pathways including Th1, Th17, and Th22. Understanding the interplay of these immune axes may contribute to a more personalized therapeutic approach based on patients' molecular profile, with the prospect of improving clinical outcome...
November 24, 2023: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/37992372/cytokine-profiles-of-chronic-urticaria-patients-and-the-effect-of-omalizumab-treatment
#16
JOURNAL ARTICLE
Ozge Can Bostan, Ebru Damadoglu, Basak Ezgi Sarac, Busra Kilic, Umit Murat Sahiner, Cagatay Karaaslan, Gul Karakaya, Ali Fuat Kalyoncu
INTRODUCTION: Cytokines are key mediators in immunological and inflammatory conditions, including chronic spontaneous urticaria (CSU). OBJECTIVES: To investigate Th1, Th2, and Th17 cytokine profiles in CSU and to evaluate the possible effect of omalizumab treatment. METHODS: Patients who were followed up for CSU, as well as healthy volunteers, were included in the study. To assess urticaria activity, the 7-day-Urticaria Activity Score (UAS-7), the Urticaria Control Test (UCT), and the Chronic Urticaria Quality of Life Questionnaire (CU-QoL) were filled...
October 1, 2023: Dermatology Practical & Conceptual
https://read.qxmd.com/read/37954580/leptin-favors-imbalance-of-antigen-specific-cd4-t-cells-associated-with-severity-of-cat-allergy
#17
JOURNAL ARTICLE
Carolina Vollmer, Aleida Dias, Marisa Sales, Priscila M Sacramento, Júlio Cesar Silva, Hugo A A Oyamada, Ulisses C Linhares, Sudhir Gupta, Taissa M Kasahara, Cleonice A M Bento
INTRODUCTION: Obesity can complicate IgE-mediated allergic diseases. In the present study, we aimed to investigate the ability of obesity-related concentrations of leptin to modulate the in vitro effector and regulatory Fel d1-specific CD4+ T-cell subsets in patients allergic to cat, considered the third most common cause of respiratory allergy in humans. METHODS: For this study, plasma and peripheral blood mononuclear cells (PBMC) from 30 cat-allergic patients with mild, moderate and severe respiratory symptoms were obtained...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37876509/biomarkers-of-ocular-allergy-and-dry-eye-disease
#18
JOURNAL ARTICLE
Mihail Zemba, Mihai-Alexandru Ionescu, Ruxandra Angela Pîrvulescu, Otilia-Maria Dumitrescu, Brănişteanu Daniel-Constantin, Mădălina Radu, Alina-Cristina Stamate, Sînziana Istrate
The most common disorders of the ocular surface are dry eye disease (DED) and ocular allergy (OA). These conditions are frequently coexisting with or without a clinical overlap and can cause a severe impact on the patient's quality of life. Therefore, it can sometimes be hard to distinguish between DED and OA because similar changes and manifestations may be present. Atopic patients can also develop DED, which can aggravate their manifestations. Moreover, patients with DED can develop ocular allergies, so these two pathological entities of the ocular surface can be considered as mutual conditions that share the same background...
2023: Romanian Journal of Ophthalmology
https://read.qxmd.com/read/37875615/respiratory-allergy-symptoms-and-cytokine-profiles-in-the-presence-of-anti-ascaris-antibody-in-giardia-lamblia-infected-children
#19
JOURNAL ARTICLE
Ana Lúcia Arruda Fontenele, Cassia Giselle de Oliveira Nóbrega, Wheverton Ricardo Correia do Nascimento, Patrícia d'Emery Alves Santos, Virginia Maria Barros de Lorena, Décio Medeiros Peixoto, Mônica Camelo Pessôa de Azevedo Albuquerque, Dirceu Solé, Vláudia Maria Assis Costa, Emanuel Sávio Cavalcanti Sarinho, Valdenia Maria Oliveira de Souza
Anti-Ascaris lumbricoides (Asc) IgE and IgG can immunomodulate the allergy; however, the influence of these isotypes has not been investigated in the giardiasis and allergy. Therefore, the frequency of respiratory allergy (RA) symptoms in Giardia lamblia-infected children, with or without anti-Asc IgE, IgG1, or IgG4 and Th1, Th2/Treg, and Th17 cytokine production, was evaluated. We performed a case-control study with children aged 2-10 years old selected by questionnaire and stool exams to form the groups: infected or uninfected with RA (G-RA, n = 55; nG-RA, n = 43); infected and uninfected without RA (G-nRA, n = 59; nG-nRA, n = 54)...
October 25, 2023: Parasitology Research
https://read.qxmd.com/read/37855284/novel-carmil2-rltpr-mutation-presenting-with-hyper-ige-and-eosinophilia-a-case-report
#20
Raha Zamani, Samaneh Zoghi, Sepideh Shahkarami, Simin Seyedpour, Raúl Jimenez Heredia, Kaan Boztug, Nima Rezaei
BACKGROUND: Inborn errors of immunity are a growing group of disorders with a wide spectrum of genotypic and phenotypic profiles. CARMIL2 (previously named RLTPR) deficiency is a recently described cause of immune dysregulation, mainly presenting with allergy, mucocutaneous infections, and inflammatory bowel disease. CARMIL2 deficiency is categorized under diseases of immune dysregulation with susceptibility to lymphoproliferative conditions. CASE PRESENTATION: Here we describe a 29-years-old male from a consanguineous family, with food and sting allergy, allergic rhinitis, facial molluscum contagiosum (viral infection of the skin in the form of umbilicated papules), eosinophilia and highly elevated serum IgE level...
October 4, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
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