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https://www.readbyqxmd.com/read/27896542/immunomodulatory-effects-of-adjuvants-cpg-mpla-and-bcg-on-the-derp2-induced-acute-asthma-at-early-life-in-an-animal-model-of-balb-c-mice
#1
V Mohammadi-Shahrokhi, A Rezaei, A Andalib, A Rahnama, A Jafarzadeh, N Eskandari
The Th1- and Treg cell-related immune responses play key roles in the modulation of Th2 cell-related allergic disorders. The aim was to evaluate the effects of CPG, MPLA, and BCG on the number of Th1-, Th2-, and Treg cell-related parameters in an animal model of asthma. BALB/c mice were divided into five groups and immunized subcutaneously (SC) on days 1, 15, and 22 with allergen Derp2. Three groups of mice were pretreated SC on days 0, 14, and 21 with CPG, CPG + MPLA, or CPG + BCG. All mice were then challenged intranasally with Derp2 on days 28-37...
November 28, 2016: Inflammation
https://www.readbyqxmd.com/read/27876361/beneficial-effects-of-galectin-9-on-allergen-specific-sublingual-immunotherapy-in-a-dermatophagoides-farinae-induced-mouse-model%C3%A2-of-chronic-asthma
#2
Masaki Ikeda, Shigeki Katoh, Hiroki Shimizu, Akira Hasegawa, Katsuyo Ohashi-Doi, Mikio Oka
BACKGROUND: Allergen-specific sublingual immunotherapy is a potential disease-modifying treatment for allergic asthma. Galectin-9 (Gal-9), a β-galactoside-binding protein with various biologic effects, acts as an immunomodulator in excessive immunologic reactions by expanding regulatory T cells (Treg) and enhancing transforming growth factor (TGF)-β signaling. We investigated the efficacy of sublingually administered Gal-9 as an adjuvant to a specific allergen in a Dermatophagoides farinae (Df)-induced mouse model of chronic asthma...
November 19, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27826960/oral-food-desensitization-in-children-with-ige-mediated-cow-s-milk-allergy-immunological-changes-underlying-desensitization
#3
Laura Perezábad, Marta Reche, Teresa Valbuena, Rosina López-Fandiño, Elena Molina, Iván López-Expósito
PURPOSE: This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population. METHODS: A group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27812173/indoleamine-2-3-dioxygenase-is-not-a-pivotal-regulator-responsible-for-suppressing-allergic-airway-inflammation-through-adipose-derived-stem-cells
#4
Kyu-Sup Cho, Mi-Kyung Park, Sue-Jean Mun, Hee-Young Park, Hak-Sun Yu, Hwan-Jung Roh
BACKGROUND: Although indoleamine 2,3-dioxygenase (IDO)-mediated immune suppression of mesenchymal stem cells (MSCs) has been revealed in septic and tumor microenvironments, the role of IDO in suppressing allergic airway inflammation by MSCs is not well documented. We evaluated the effects of adipose-derived stem cells (ASCs) on allergic inflammation in IDO-knockout (KO) asthmatic mice or asthmatic mice treated with ASCs derived from IDO-KO mice. METHODS AND FINDINGS: ASCs were injected intravenously in wild-type (WT) and IDO-KO asthmatic mice...
2016: PloS One
https://www.readbyqxmd.com/read/27788149/transcriptional-profiling-of-egg-allergy-and-relationship-to-disease-phenotype
#5
Roman Kosoy, Charuta Agashe, Alexander Grishin, Donald Y Leung, Robert A Wood, Scott H Sicherer, Stacie M Jones, A Wesley Burks, Wendy F Davidson, Robert W Lindblad, Peter Dawson, Miriam Merad, Brian A Kidd, Joel T Dudley, Hugh A Sampson, M Cecilia Berin
BACKGROUND: Egg allergy is one of the most common food allergies of childhood. There is a lack of information on the immunologic basis of egg allergy beyond the role of IgE. OBJECTIVE: To use transcriptional profiling as a novel approach to uncover immunologic processes associated with different phenotypes of egg allergy. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from egg-allergic children who were defined as reactive (BER) or tolerant (BET) to baked egg, and from food allergic controls (AC) who were egg non-allergic...
2016: PloS One
https://www.readbyqxmd.com/read/27770456/control-of-asthma-by-omalizumab-the-role-of-cd4-foxp3-regulatory-t-cells
#6
LETTER
F Amat, P Tallon, A P Foray, B Michaud, N Lambert, P Saint-Pierre, L Chatenoud, J Just
No abstract text is available yet for this article.
December 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27643438/foxp3-tregs-require-wasp-to-restrain-th2-mediated-food-allergy
#7
Willem S Lexmond, Jeremy A Goettel, Jonathan J Lyons, Justin Jacobse, Marion M Deken, Monica G Lawrence, Thomas H DiMaggio, Daniel Kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste C Nelson, Nina Jones, Kelly D Stone, Fabio Candotti, Edmond H H M Rings, Adrian J Thrasher, Joshua D Milner, Scott B Snapper, Edda Fiebiger
In addition to the infectious consequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly understood exaggerated immune responses that result in autoimmunity and elevated levels of serum IgE. Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens. WASP-deficient animals displayed an adjuvant-free IgE-sensitization to chow antigens that was most pronounced for wheat and soy and occurred under specific pathogen-free as well as germ-free housing conditions...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27633092/adenovirus-mediated-foxp3-expression-in-lung-epithelial-cells-reduces-airway-inflammation-in-ovalbumin-and-cockroach-induced-asthma-model
#8
Soojin Park, Hwan-Suck Chung, Dasom Shin, Kyung-Hwa Jung, Hyunil Lee, Junghee Moon, Hyunsu Bae
Foxp3 is a master regulator of CD4(+)CD25(+) regulatory T-cell (Treg) function and is also a suppressor of SKP2 and HER2/ErbB2. There are an increasing number of reports describing the functions of Foxp3 in cell types other than Tregs. In this context, we evaluated the functions of Foxp3 in ovalbumin- and cockroach-induced asthma models. Foxp3-EGFP-expressing adenovirus or EGFP control adenovirus was administered intratracheally (i.t.), followed by challenge with ovalbumin (OVA) or cockroach extract to induce asthma...
September 16, 2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27561877/baicalein-induces-cd4-foxp3-t-cells-and-enhances-intestinal-barrier-function-in-a-mouse-model-of-food-allergy
#9
Min-Jung Bae, Hee Soon Shin, Hye-Jeong See, Sun Young Jung, Da-Ae Kwon, Dong-Hwa Shon
The incidence of food allergy, which is triggered by allergen permeation of the gastrointestinal tract followed by a T-helper (Th) 2-mediated immune response, has been increasing annually worldwide. We examined the effects of baicalein (5,6,7-trihydroxyflavone), a flavonoid from Scutellaria baicalensis used in oriental herbal medicine, on regulatory T (Treg) cell induction and intestinal barrier function through the regulation of tight junctions in a mouse model of food allergy. An allergic response was induced by oral challenge with ovalbumin, and the incidence of allergic symptoms and T cell-related activity in the mesenteric lymph nodes were analyzed with and without the presence of baicalein...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27558586/allergen-specific-immunotherapy-is-it-vaccination-against-toxins-after-all
#10
Martin F Bachmann, Thomas M Kündig
IgE-mediated allergies, in particular allergic rhino-conjunctivitis and asthma, have reached epidemic proportions, affecting about one third of the population in developed countries. The most effective treatment for allergies is specific immunotherapy (SIT), which involves the injection of increasing doses of an allergen extract to allergic individuals. The current form of SIT was first introduced 1911 and recently celebrated its 100(th) birthday for the treatment of hay fever. The concept of this therapy at the time was straight-forward, since it was believed that pollen contained toxins against which the patient could be vaccinated...
August 24, 2016: Allergy
https://www.readbyqxmd.com/read/27525046/epigenetic-features-of-foxp3-in-children-with-cow-s-milk-allergy
#11
Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D'Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore, Roberto Berni Canani
BACKGROUND: DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. RESULTS: Forty children (aged 3-18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4)...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27403198/effects-of-sohamhyoong-tang-on-ovalbumin-induced-allergic-reaction-in-balb-c-mice
#12
So Hyun Jo, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee, Dae Ki Kim, Min Cheol Park
IgE-mediated mast cell degranulation and excessive Th2 cells activation are major features of various allergic diseases. Sohamhyoong-tang has been reported to have anti-inflammatory and antibacterial effects. In this study, we investigated the inhibitory effect of Sohamhyoong-tang extract (SHHTE) on allergic symptoms and inflammatory responses in ovalbumin- (OVA-) sensitized BALB/c mice. The mice were sensitized with OVA and alum at 2-week intervals and then orally given SHHTE for 13 days followed by intradermal OVA injection...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27322476/cell-therapy-for-prophylactic-tolerance-in-immunoglobulin-e-mediated-allergy
#13
Ulrike Baranyi, Andreas M Farkas, Karin Hock, Benedikt Mahr, Birgit Linhart, Martina Gattringer, Margit Focke-Tejkl, Arnd Petersen, Fritz Wrba, Thomas Rülicke, Rudolf Valenta, Thomas Wekerle
BACKGROUND: Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based therapy inducing permanent allergen-specific immunological tolerance for preventing IgE-mediated allergy. METHODS: Wild-type mice were treated with allergen-expressing bone marrow cells under a short course of tolerogenic immunosuppression (mTOR inhibition and costimulation blockade)...
May 2016: EBioMedicine
https://www.readbyqxmd.com/read/27262513/immune-inflammatory-responses-in-atherosclerosis-role-of-an-adaptive-immunity-mainly-driven-by-t-and-b-cells
#14
Dimitry A Chistiakov, Alexander N Orekhov, Yuri V Bobryshev
Adaptive immune response plays an important role in atherogenesis. In atherosclerosis, the proinflammatory immune response driven by Th1 is predominant but the anti-inflammatory response mediated mainly by regulatory T cells is also present. The role of Th2 and Th17 cells in atherogenesis is still debated. In the plaque, other T helper cells can be observed such as Th9 and Th22 but is little is known about their impact in atherosclerosis. Heterogeneity of CD4(+) T cell subsets presented in the plaque may suggest for plasticity of T cell that can switch the phenotype dependening on the local microenvironment and activating/blocking stimuli...
September 2016: Immunobiology
https://www.readbyqxmd.com/read/27262379/adalimumab-ameliorates-ova-induced-airway-inflammation-in-mice-role-of-cd4-cd25-foxp3-regulatory-t-cells
#15
Mohamed G Elsakkar, Olla A Sharaki, Dina M Abdallah, Dalia K Mostafa, Fadia T Shekondali
Asthma is a chronic inflammatory heterogeneous disorder initiated by a dysregulated immune response which drives disease development in susceptible individuals. Though T helper 2 (TH2) biased responses are usually linked to eosinophilic asthma, other Th cell subsets induce neutrophilic airway inflammation which provokes the most severe asthmatic phenotypes. A growing evidence highlights the role of T regulatory (Treg) cells in damping abnormal Th responses and thus inhibiting allergy and asthma. Therefore, strategies to induce or augment Treg cells hold promise for treatment and prevention of allergic airway inflammation...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27259856/regulatory-t-cells-control-th2-dominant-murine-autoimmune-gastritis
#16
Jessica Harakal, Claudia Rival, Hui Qiao, Kenneth S Tung
Pernicious anemia and gastric carcinoma are serious sequelae of autoimmune gastritis (AIG). Our study indicates that in adult C57BL/6-DEREG mice expressing a transgenic diphtheria toxin receptor under the Foxp3 promoter, transient regulatory T cell (Treg) depletion results in long-lasting AIG associated with both H(+)K(+)ATPase and intrinsic factor autoantibody responses. Although functional Tregs emerge over time during AIG occurrence, the effector T cells rapidly become less susceptible to Treg-mediated suppression...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27235977/laser-facilitated-epicutaneous-immunotherapy-to-ige-mediated-allergy
#17
Mudnakudu Nagaraju Kiran Kumar, Chang Zhou, Mei X Wu
Allergen specific immunotherapy has been shown to be the only effective treatment for long-lasting clinical benefit to IgE-mediated allergic diseases, but a fewer than 5% of patients choose the treatment because of inconvenience and a high risk of anaphylaxis. Recently, epicutaneous allergen-specific immunotherapy (EPIT) has proven effective, yet with limitations owing to strong skin reactions. We demonstrate here safer and faster EPIT, named μEPIT, by delivering powdered allergen and adjuvants into many micropores in the epidermis...
August 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27216911/critical-roles-of-adenosine-a2a-receptor-in-regulating-the-balance-of-treg-th17cells-in-allergic-asthma
#18
Linlin Wang, Huanying Wan, Wei Tang, Yingmeng Ni, Xiaoxia Hou, Lina Pan, Yuanlin Song, Guochao Shi
INTRODUCTION: Deficiency of Treg cells and hyperactivity of Th17 cells together are involved in the immunological pathogenesis of asthma. The adenosine A2AR plays a critical role in the increased Foxp3 expression of Treg cells and the decreased Th17 generation. OBJECTIVE: The study aimed to investigate A2AR expression in peripheral blood and its regulatory effect on balance of Treg/Th17 cells in asthma. METHODS: 31 patients with chronic persistent asthma were recruited and divided into 18 intermittent to mild asthma patients, 13 moderate to severe asthma patients...
May 23, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27200487/the-impact-of-langerin-cd207-dendritic-cells-and-foxp3-treg-cells-in-the-small-bowel-mucosa-of-children-with-celiac-disease-and-atopic-dermatitis-in-comparison-to-children-with-functional-gastrointestinal-disorders
#19
Tamara Vorobjova, Krista Ress, Katrin Luts, Oivi Uibo, Raivo Uibo
In the present study we aimed to evaluate the impact of langerin (CD207)+ dendritic cells (DCs) and FOXP3+ Treg cells in the intestinal mucosa of children with celiac disease (CD) and atopic dermatitis (AD) in comparison to children with functional gastrointestinal disorders (FGD). Seventy-five children (37 male, mean age 8.4 ± 4.8 years), who randomly underwent small bowel biopsy, were studied. The CD was diagnosed in 14 children, including five persons with concomitant AD (all positive for anti-tissue transglutaminase IgA antibodies and with small bowel atrophy)...
August 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27186807/anti-food-allergic-activity-of-sulfated-polysaccharide-from-gracilaria-lemaneiformis-is-dependent-on-immunosuppression-and-inhibition-of-p38-mapk
#20
Qing-Mei Liu, Yang Yang, Soheila J Maleki, Marcos Alcocer, Sha-Sha Xu, Chao-Lan Shi, Min-Jie Cao, Guang-Ming Liu
Polysaccharides from Gracilaria lemaneiformis in particular possess various bioactive functions, but their antiallergic activity remains incompletely defined. Sulfated polysaccharide from Gracilaria lemaneiformis (GLSP) was obtained by water extraction and ethanol precipitation followed by column chromatography. BALB/c mice, RBL-2H3, and KU812 cells were used for verifying the anti food allergic activity of GLSP. According to the results of mice experiment, GLSP was able to alleviate allergy symptoms, to reduce TM-specific IgE and IgG1, to suppress Th2 cell polarization, and to promote the function of regulatory T (Treg) cells...
June 8, 2016: Journal of Agricultural and Food Chemistry
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