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https://www.readbyqxmd.com/read/27902832/association-of-irritability-and-anxiety-with-the-neural-mechanisms-of-implicit-face-emotion-processing-in-youths-with-psychopathology
#1
Joel Stoddard, Wan-Ling Tseng, Pilyoung Kim, Gang Chen, Jennifer Yi, Laura Donahue, Melissa A Brotman, Kenneth E Towbin, Daniel S Pine, Ellen Leibenluft
Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology. Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging...
November 30, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27871637/comparing-brain-morphometry-across-multiple-childhood-psychiatric-disorders
#2
Andrea L Gold, Melissa A Brotman, Nancy E Adleman, Sara N Lever, Elizabeth R Steuber, Stephen J Fromm, Sven C Mueller, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: In both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs. METHOD: 3-Tesla T1-weighted magnetic resonance imaging scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV)...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/26924633/aberrant-intrinsic-functional-connectivity-within-and-between-corticostriatal-and-temporal-parietal-networks-in-adults-and-youth-with-bipolar-disorder
#3
J Stoddard, S J Gotts, M A Brotman, S Lever, D Hsu, C Zarate, M Ernst, D S Pine, E Leibenluft
BACKGROUND: Major questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas. METHOD: We collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78)...
May 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26892942/neural-correlates-of-irritability-in-disruptive-mood-dysregulation-and-bipolar-disorders
#4
Jillian Lee Wiggins, Melissa A Brotman, Nancy E Adleman, Pilyoung Kim, Allison H Oakes, Richard C Reynolds, Gang Chen, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Bipolar disorder and disruptive mood dysregulation disorder (DMDD) are clinically and pathophysiologically distinct, yet irritability can be a clinical feature of both illnesses. The authors examine whether the neural mechanisms mediating irritability differ between bipolar disorder and DMDD, using a face emotion labeling paradigm because such labeling is deficient in both patient groups. The authors hypothesized that during face emotion labeling, irritability would be associated with dysfunctional activation in the amygdala and other temporal and prefrontal regions in both disorders, but that the nature of these associations would differ between DMDD and bipolar disorder...
July 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/25544024/aberrant-amygdala-intrinsic-functional-connectivity-distinguishes-youths-with-bipolar-disorder-from-those-with-severe-mood-dysregulation
#5
Joel Stoddard, Derek Hsu, Richard C Reynolds, Melissa A Brotman, Monique Ernst, Daniel S Pine, Ellen Leibenluft, Daniel P Dickstein
It remains unclear the degree to which youths with episodic mania (bipolar disorder; BD) vs. those with chronic, severe irritability (severe mood dysregulation, SMD) should be placed in similar or distinct diagnostic groups. Addressing this clinically meaningful question requires greater understanding of the neural alterations underlying both disorders. We evaluated resting state functional magnetic resonance imaging data of 53 youths (14 BD, 20 healthy volunteers (HV), and 19 SMD, ages 9-18.5 years). Seed regions of interest were the bilateral basolateral, superficial and centromedial amygdala, defined using the Juelich probabilistic atlas...
February 28, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/24617738/parametric-modulation-of-neural-activity-during-face-emotion-processing-in-unaffected-youth-at-familial-risk-for-bipolar-disorder
#6
Melissa A Brotman, Christen M Deveney, Laura A Thomas, Kendra E Hinton, Jennifer Y Yi, Daniel S Pine, Ellen Leibenluft
OBJECTIVES: Both patients with pediatric bipolar disorder (BD) and unaffected youth at familial risk (AR) for the illness show impairments in face emotion labeling. Few studies, however, have examined brain regions engaged in AR youth when processing emotional faces. Moreover, studies have yet to explore neural responsiveness to subtle changes in face emotion in AR youth. METHODS: Sixty-four unrelated youth, including 20 patients with BD, 15 unaffected AR youth, and 29 healthy comparisons (HC), completed functional magnetic resonance imaging...
November 2014: Bipolar Disorders
https://www.readbyqxmd.com/read/24493839/neural-response-during-explicit-and-implicit-face-processing-varies-developmentally-in-bipolar-disorder
#7
Christen M Deveney, Melissa A Brotman, Laura A Thomas, Kendra E Hinton, Eli M Muhrer, Richard C Reynolds, Nancy E Adleman, Carlos A Zarate, Daniel S Pine, Ellen Leibenluft
Both children and adults with bipolar disorder (BD) exhibit face emotion labeling deficits and neural circuitry dysfunction in response to emotional faces. However, few studies have compared these groups directly to distinguish effects of age and diagnosis. Such studies are important to begin to elucidate the developmental trajectory of BD and facilitate its diagnosis, prevention and treatment. This functional magnetic resonance imaging study compares 41 individuals with BD (19 children; 22 adults) and 44 age-matched healthy individuals (25 children; 19 adults) when making explicit or implicit judgments about angry or happy face morphs across a range of emotion intensity...
December 2014: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/24281907/a-systems-neuroscience-approach-to-the-pathophysiology-of-pediatric-mood-and-anxiety-disorders
#8
REVIEW
Wan-Ling Tseng, Ellen Leibenluft, Melissa A Brotman
Emotional dysregulation is a core feature of pediatric mood and anxiety disorders. Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain. This chapter reviews recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders, focusing on the neural mechanisms underlying these disorders. Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments...
2014: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/23958598/a-developmental-study-on-the-neural-circuitry-mediating-response-flexibility-in-bipolar-disorder
#9
Judah Weathers, Melissa A Brotman, Christen M Deveney, Pilyoung Kim, Carlos Zarate, Stephen Fromm, Daniel Pine, Ellen Leibenluft
Cross-sectional neuroimaging studies are an important first step in examining developmental differences in brain function between adults and youth with bipolar disorder (BD). Impaired response flexibility may contribute to reduced ability to modify goal-directed behavior in BD appropriately. We compared neural circuitry mediating this process in child (CBD) vs. adult BD (ABD) and age-matched healthy subjects. fMRI data from 15 CBD, 23 ABD, 20 healthy children, and 27 healthy adults were acquired during a response flexibility paradigm, a task where subjects inhibit a prepotent response and execute an alternative response...
October 30, 2013: Psychiatry Research
https://www.readbyqxmd.com/read/23930595/fronto-limbic-striatal-dysfunction-in-pediatric-and-adult-patients-with-bipolar-disorder-impact-of-face-emotion-and-attentional-demands
#10
M A Brotman, W-L Tseng, A K Olsavsky, S J Fromm, E J Muhrer, J G Rutenberg, C M Deveney, N E Adleman, C A Zarate, D S Pine, E Leibenluft
BACKGROUND: Research in bipolar disorder (BD) implicates fronto-limbic-striatal dysfunction during face emotion processing but it is unknown how such dysfunction varies by task demands, face emotion and patient age. METHOD: During functional magnetic resonance imaging (fMRI), 181 participants, including 62 BD (36 children and 26 adults) and 119 healthy comparison (HC) subjects (57 children and 62 adults), engaged in constrained and unconstrained processing of emotional (angry, fearful, happy) and non-emotional (neutral) faces...
June 2014: Psychological Medicine
https://www.readbyqxmd.com/read/23541333/abnormal-fusiform-activation-during-emotional-face-encoding-assessed-with-functional-magnetic-resonance-imaging
#11
Nancy E Adleman, Reilly R Kayser, Aviva K Olsavsky, Brian L Bones, Eli J Muhrer, Stephen J Fromm, Daniel S Pine, Carlos Zarate, Ellen Leibenluft, Melissa A Brotman
This functional magnetic resonance imaging study shows that children and adults with bipolar disorder (BD), compared with healthy subjects, exhibit impaired memory for emotional faces and abnormal fusiform activation during encoding. Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker.
May 30, 2013: Psychiatry Research
https://www.readbyqxmd.com/read/22700308/effect-of-through-plane-motion-on-left-ventricular-rotation-a-study-using-slice-following-harmonic-phase-imaging
#12
David Brotman, Ziheng Zhang, Smita Sampath
Noninvasive quantification of regional left ventricular rotation may improve understanding of cardiac function. Current methods used to quantify rotation typically acquire data on a set of prescribed short-axis slices, neglecting effects due to through-plane myocardial motion. We combine principles of slice-following tagged imaging with harmonic phase analysis methods to account for through-plane motion in regional rotation measurements. We compare rotation and torsion measurements obtained using our method to those obtained from imaging datasets acquired without slice-following...
May 2013: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/22650379/cross-sectional-and-longitudinal-abnormalities-in-brain-structure-in-children-with-severe-mood-dysregulation-or-bipolar-disorder
#13
COMPARATIVE STUDY
Nancy E Adleman, Stephen J Fromm, Varun Razdan, Reilly Kayser, Daniel P Dickstein, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft
BACKGROUND: There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV...
November 2012: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/22581312/a-developmental-study-of-the-neural-circuitry-mediating-motor-inhibition-in-bipolar-disorder
#14
Judah D Weathers, Argyris Stringaris, Christen M Deveney, Melissa A Brotman, Carlos A Zarate, Megan E Connolly, Stephen J Fromm, Stephanie B LeBourdais, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Despite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder, few studies have compared adults and youths with bipolar disorder. Deficits in motor inhibition are thought to play an important role in the pathophysiology of the illness across the age spectrum. The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers. METHOD: Participants were pediatric (N=16) and adult (N=23) patients with bipolar disorder and healthy child (N=21) and adult (N=29) volunteers...
June 2012: American Journal of Psychiatry
https://www.readbyqxmd.com/read/22535257/differing-amygdala-responses-to-facial-expressions-in-children-and-adults-with-bipolar-disorder
#15
Pilyoung Kim, Laura A Thomas, Brooke H Rosen, Alexander M Moscicki, Melissa A Brotman, Carlos A Zarate, R James R Blair, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Child and adult bipolar patients show both behavioral deficits in face emotion processing and abnormal amygdala activation. However, amygdala function in pediatric relative to adult bipolar patients has not been compared directly. The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects. METHOD: Amygdala responses to emotional facial expressions were examined in pediatric (N=18) and adult (N=17) bipolar patients and in healthy child (N=15) and adult (N=22) volunteers...
June 2012: American Journal of Psychiatry
https://www.readbyqxmd.com/read/22414616/striatal-dysfunction-during-failed-motor-inhibition-in-children-at-risk-for-bipolar-disorder
#16
Christen M Deveney, Megan E Connolly, Sarah E Jenkins, Pilyoung Kim, Stephen J Fromm, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft
BACKGROUND: A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD. METHODS: 19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3 T scanner...
August 7, 2012: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/22365465/amygdala-hyperactivation-during-face-emotion-processing-in-unaffected-youth-at-risk-for-bipolar-disorder
#17
Aviva K Olsavsky, Melissa A Brotman, Julia G Rutenberg, Eli J Muhrer, Christen M Deveney, Stephen J Fromm, Kenneth Towbin, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Youth at familial risk for bipolar disorder (BD) show deficits in face emotion processing, but the neural correlates of these deficits have not been examined. This preliminary study tests the hypothesis that, relative to healthy comparison (HC) subjects, both BD subjects and youth at risk for BD (i.e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder...
March 2012: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/22024484/neural-correlates-of-cognitive-flexibility-in-children-at-risk-for-bipolar-disorder
#18
Pilyoung Kim, Sarah E Jenkins, Megan E Connolly, Christen M Deveney, Stephen J Fromm, Melissa A Brotman, Eric E Nelson, Daniel S Pine, Ellen Leibenluft
BACKGROUND: Youth with bipolar disorder (BD) show behavioral and neural deficits in cognitive flexibility; however, whether such deficits exist among youths at risk for BD has not been explored. METHODS: The current fMRI study examined the neural basis of cognitive flexibility in BD youth (n = 28), unaffected youth at risk for BD (AR; n = 13), and healthy volunteer youth (HV; n = 21) by comparing brain activation patterns while participants performed the change task...
January 2012: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/20215924/a-genome-wide-association-study-of-amygdala-activation-in-youths-with-and-without-bipolar-disorder
#19
Xinmin Liu, Nirmala Akula, Martha Skup, Melissa A Brotman, Ellen Leibenluft, Francis J McMahon
OBJECTIVE: Functional magnetic resonance imaging is commonly used to characterize brain activity underlying a variety of psychiatric disorders. A previous functional magnetic resonance imaging study found that amygdala activation during a face-processing task differed between pediatric patients with bipolar disorder (BD) and healthy controls. We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype. METHOD: Thirty-nine patients with BD and 29 healthy controls who had previously undergone functional magnetic resonance imaging when viewing a neutral face were genotyped using a genome-wide single-nucleotide polymorphism (SNP) array...
January 2010: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/19917597/amygdala-activation-during-emotion-processing-of-neutral-faces-in-children-with-severe-mood-dysregulation-versus-adhd-or-bipolar-disorder
#20
COMPARATIVE STUDY
Melissa A Brotman, Brendan A Rich, Amanda E Guyer, Jessica R Lunsford, Sarah E Horsey, Michelle M Reising, Laura A Thomas, Stephen J Fromm, Kenneth Towbin, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: To understand disorder-unique and common pathophysiology, studies in multiple patient groups with overlapping symptoms are needed. Deficits in emotion processing and hyperarousal symptoms are prominent features of bipolar disorder, attention deficit hyperactivity disorder (ADHD), and severe mood dysregulation. The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...
January 2010: American Journal of Psychiatry
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