Read by QxMD icon Read

Brotman mri

Gang Chen, Paul A Taylor, Simone P Haller, Katharina Kircanski, Joel Stoddard, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman, Robert W Cox
Intraclass correlation (ICC) is a reliability metric that gauges similarity when, for example, entities are measured under similar, or even the same, well-controlled conditions, which in MRI applications include runs/sessions, twins, parent/child, scanners, sites, and so on. The popular definitions and interpretations of ICC are usually framed statistically under the conventional ANOVA platform. Here, we provide a comprehensive overview of ICC analysis in its prior usage in neuroimaging, and we show that the standard ANOVA framework is often limited, rigid, and inflexible in modeling capabilities...
December 7, 2017: Human Brain Mapping
David Pagliaccio, Jillian Lee Wiggins, Nancy E Adleman, Alexa Curhan, Susan Zhang, Kenneth E Towbin, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Disruptive mood dysregulation disorder (DMDD), characterized by severe irritability, and attention-deficit/hyperactivity disorder (ADHD) are highly comorbid. This is the first study to characterize neural and behavioral similarities and differences in attentional functioning across these disorders. METHOD: Twenty-seven healthy volunteers, 31 patients with DMDD, and 25 patients with ADHD (8 to 18 years old) completed a functional magnetic resonance imaging attention task...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
Lauren K White, Stefanie Sequeira, Jennifer C Britton, Melissa A Brotman, Andrea L Gold, Erin Berman, Kenneth Towbin, Rany Abend, Nathan A Fox, Yair Bar-Haim, Ellen Leibenluft, Daniel S Pine
OBJECTIVE: In the treatment of anxiety disorders, attention bias modification therapy (ABMT) and cognitive-behavioral therapy (CBT) may have complementary effects by targeting different aspects of perturbed threat responses and behaviors. ABMT may target rapid, implicit threat reactions, whereas CBT may target slowly deployed threat responses. The authors used amygdala-based connectivity during a threat-attention task and a randomized controlled trial design to evaluate potential complementary features of these treatments in pediatric anxiety disorders...
August 1, 2017: American Journal of Psychiatry
Jillian Lee Wiggins, Melissa A Brotman, Nancy E Adleman, Pilyoung Kim, Caroline G Wambach, Richard C Reynolds, Gang Chen, Kenneth Towbin, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Bipolar disorder (BD) is highly heritable. Neuroimaging studies comparing unaffected youth at high familial risk for BD (i.e., those with a first-degree relative with the disorder; termed "high-risk" [HR]) to "low-risk" (LR) youth (i.e., those without a first-degree relative with BD) and to patients with BD may help identify potential brain-based markers associated with risk (i.e., regions where HR+BD≠LR), resilience (HR≠BD+LR), or illness (BD≠HR+LR). METHOD: During functional magnetic resonance imaging (fMRI), 99 youths (i...
January 2017: Journal of the American Academy of Child and Adolescent Psychiatry
Joel Stoddard, Wan-Ling Tseng, Pilyoung Kim, Gang Chen, Jennifer Yi, Laura Donahue, Melissa A Brotman, Kenneth E Towbin, Daniel S Pine, Ellen Leibenluft
Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology. Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging...
January 1, 2017: JAMA Psychiatry
Andrea L Gold, Melissa A Brotman, Nancy E Adleman, Sara N Lever, Elizabeth R Steuber, Stephen J Fromm, Sven C Mueller, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: In both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs. METHOD: 3-Tesla T1-weighted magnetic resonance imaging scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV)...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
J Stoddard, S J Gotts, M A Brotman, S Lever, D Hsu, C Zarate, M Ernst, D S Pine, E Leibenluft
BACKGROUND: Major questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas. METHOD: We collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10-50 years) with BD (n = 39) and healthy volunteers (HV; n = 78)...
May 2016: Psychological Medicine
Jillian Lee Wiggins, Melissa A Brotman, Nancy E Adleman, Pilyoung Kim, Allison H Oakes, Richard C Reynolds, Gang Chen, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Bipolar disorder and disruptive mood dysregulation disorder (DMDD) are clinically and pathophysiologically distinct, yet irritability can be a clinical feature of both illnesses. The authors examine whether the neural mechanisms mediating irritability differ between bipolar disorder and DMDD, using a face emotion labeling paradigm because such labeling is deficient in both patient groups. The authors hypothesized that during face emotion labeling, irritability would be associated with dysfunctional activation in the amygdala and other temporal and prefrontal regions in both disorders, but that the nature of these associations would differ between DMDD and bipolar disorder...
July 1, 2016: American Journal of Psychiatry
Joel Stoddard, Derek Hsu, Richard C Reynolds, Melissa A Brotman, Monique Ernst, Daniel S Pine, Ellen Leibenluft, Daniel P Dickstein
It remains unclear the degree to which youths with episodic mania (bipolar disorder; BD) vs. those with chronic, severe irritability (severe mood dysregulation, SMD) should be placed in similar or distinct diagnostic groups. Addressing this clinically meaningful question requires greater understanding of the neural alterations underlying both disorders. We evaluated resting state functional magnetic resonance imaging data of 53 youths (14 BD, 20 healthy volunteers (HV), and 19 SMD, ages 9-18.5 years). Seed regions of interest were the bilateral basolateral, superficial and centromedial amygdala, defined using the Juelich probabilistic atlas...
February 28, 2015: Psychiatry Research
Melissa A Brotman, Christen M Deveney, Laura A Thomas, Kendra E Hinton, Jennifer Y Yi, Daniel S Pine, Ellen Leibenluft
OBJECTIVES: Both patients with pediatric bipolar disorder (BD) and unaffected youth at familial risk (AR) for the illness show impairments in face emotion labeling. Few studies, however, have examined brain regions engaged in AR youth when processing emotional faces. Moreover, studies have yet to explore neural responsiveness to subtle changes in face emotion in AR youth. METHODS: Sixty-four unrelated youth, including 20 patients with BD, 15 unaffected AR youth, and 29 healthy comparisons (HC), completed functional magnetic resonance imaging...
November 2014: Bipolar Disorders
Christen M Deveney, Melissa A Brotman, Laura A Thomas, Kendra E Hinton, Eli M Muhrer, Richard C Reynolds, Nancy E Adleman, Carlos A Zarate, Daniel S Pine, Ellen Leibenluft
Both children and adults with bipolar disorder (BD) exhibit face emotion labeling deficits and neural circuitry dysfunction in response to emotional faces. However, few studies have compared these groups directly to distinguish effects of age and diagnosis. Such studies are important to begin to elucidate the developmental trajectory of BD and facilitate its diagnosis, prevention and treatment. This functional magnetic resonance imaging study compares 41 individuals with BD (19 children; 22 adults) and 44 age-matched healthy individuals (25 children; 19 adults) when making explicit or implicit judgments about angry or happy face morphs across a range of emotion intensity...
December 2014: Social Cognitive and Affective Neuroscience
Wan-Ling Tseng, Ellen Leibenluft, Melissa A Brotman
Emotional dysregulation is a core feature of pediatric mood and anxiety disorders. Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain. This chapter reviews recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders, focusing on the neural mechanisms underlying these disorders. Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments...
2014: Current Topics in Behavioral Neurosciences
Judah Weathers, Melissa A Brotman, Christen M Deveney, Pilyoung Kim, Carlos Zarate, Stephen Fromm, Daniel Pine, Ellen Leibenluft
Cross-sectional neuroimaging studies are an important first step in examining developmental differences in brain function between adults and youth with bipolar disorder (BD). Impaired response flexibility may contribute to reduced ability to modify goal-directed behavior in BD appropriately. We compared neural circuitry mediating this process in child (CBD) vs. adult BD (ABD) and age-matched healthy subjects. fMRI data from 15 CBD, 23 ABD, 20 healthy children, and 27 healthy adults were acquired during a response flexibility paradigm, a task where subjects inhibit a prepotent response and execute an alternative response...
October 30, 2013: Psychiatry Research
M A Brotman, W-L Tseng, A K Olsavsky, S J Fromm, E J Muhrer, J G Rutenberg, C M Deveney, N E Adleman, C A Zarate, D S Pine, E Leibenluft
BACKGROUND: Research in bipolar disorder (BD) implicates fronto-limbic-striatal dysfunction during face emotion processing but it is unknown how such dysfunction varies by task demands, face emotion and patient age. METHOD: During functional magnetic resonance imaging (fMRI), 181 participants, including 62 BD (36 children and 26 adults) and 119 healthy comparison (HC) subjects (57 children and 62 adults), engaged in constrained and unconstrained processing of emotional (angry, fearful, happy) and non-emotional (neutral) faces...
June 2014: Psychological Medicine
Nancy E Adleman, Reilly R Kayser, Aviva K Olsavsky, Brian L Bones, Eli J Muhrer, Stephen J Fromm, Daniel S Pine, Carlos Zarate, Ellen Leibenluft, Melissa A Brotman
This functional magnetic resonance imaging study shows that children and adults with bipolar disorder (BD), compared with healthy subjects, exhibit impaired memory for emotional faces and abnormal fusiform activation during encoding. Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker.
May 30, 2013: Psychiatry Research
David Brotman, Ziheng Zhang, Smita Sampath
Noninvasive quantification of regional left ventricular rotation may improve understanding of cardiac function. Current methods used to quantify rotation typically acquire data on a set of prescribed short-axis slices, neglecting effects due to through-plane myocardial motion. We combine principles of slice-following tagged imaging with harmonic phase analysis methods to account for through-plane motion in regional rotation measurements. We compare rotation and torsion measurements obtained using our method to those obtained from imaging datasets acquired without slice-following...
May 2013: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Nancy E Adleman, Stephen J Fromm, Varun Razdan, Reilly Kayser, Daniel P Dickstein, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft
BACKGROUND: There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time. Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV...
November 2012: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Judah D Weathers, Argyris Stringaris, Christen M Deveney, Melissa A Brotman, Carlos A Zarate, Megan E Connolly, Stephen J Fromm, Stephanie B LeBourdais, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Despite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder, few studies have compared adults and youths with bipolar disorder. Deficits in motor inhibition are thought to play an important role in the pathophysiology of the illness across the age spectrum. The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers. METHOD: Participants were pediatric (N=16) and adult (N=23) patients with bipolar disorder and healthy child (N=21) and adult (N=29) volunteers...
June 2012: American Journal of Psychiatry
Pilyoung Kim, Laura A Thomas, Brooke H Rosen, Alexander M Moscicki, Melissa A Brotman, Carlos A Zarate, R James R Blair, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: Child and adult bipolar patients show both behavioral deficits in face emotion processing and abnormal amygdala activation. However, amygdala function in pediatric relative to adult bipolar patients has not been compared directly. The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects. METHOD: Amygdala responses to emotional facial expressions were examined in pediatric (N=18) and adult (N=17) bipolar patients and in healthy child (N=15) and adult (N=22) volunteers...
June 2012: American Journal of Psychiatry
Christen M Deveney, Megan E Connolly, Sarah E Jenkins, Pilyoung Kim, Stephen J Fromm, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft
BACKGROUND: A better understanding of the neural underpinnings of bipolar disorder (BD) can be obtained by examining brain activity in symptom-free individuals at risk for BD. This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD. METHODS: 19 euthymic youths with BD, 13 asymptomatic youths with a first-degree relative with BD, and 21 healthy comparison children completed the stop signal task in a 3 T scanner...
August 7, 2012: Progress in Neuro-psychopharmacology & Biological Psychiatry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"