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https://www.readbyqxmd.com/read/29615383/hiv-clustering-in-mississippi-spatial-epidemiological-study-to-inform-implementation-science-in-the-deep-south
#1
Thomas J Stopka, Lauren Brinkley-Rubinstein, Kendra Johnson, Philip A Chan, Marga Hutcheson, Richard Crosby, Deirdre Burke, Leandro Mena, Amy Nunn
BACKGROUND: In recent years, more than half of new HIV infections in the United States occur among African Americans in the Southeastern United States. Spatial epidemiological analyses can inform public health responses in the Deep South by identifying HIV hotspots and community-level factors associated with clustering. OBJECTIVE: The goal of this study was to identify and characterize HIV clusters in Mississippi through analysis of state-level HIV surveillance data...
April 3, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29584848/hiv-preexposure-prophylaxis-a-review
#2
REVIEW
James Riddell, K Rivet Amico, Kenneth H Mayer
Importance: About 40 000 Americans and 2 million people worldwide are newly infected with HIV each year. The combination antiretroviral regimen, tenofovir disoproxil fumarate (TDF)/emtricitabine, taken as a single pill once daily, has been shown to prevent HIV transmission but is used by fewer than 20% of people who could benefit in the United States. Observations: PubMed was searched on February 15, 2018, using the search terms pre-exposure, prophylaxis, HIV, and PrEP to identify English-language articles published between 2010 and 2018...
March 27, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29578895/concerns-about-a-study-on-sexually-transmitted-infections-after-initiation-of-hiv-preexposure-prophylaxis
#3
Julia L Marcus, Jonathan E Volk, Jonathan M Snowden
No abstract text is available yet for this article.
April 24, 2018: AIDS
https://www.readbyqxmd.com/read/29565183/a-mobile-health-strategy-to-support-adherence-to-antiretroviral-preexposure-prophylaxis
#4
Jonathan D Fuchs, Kristefer Stojanovski, Eric Vittinghoff, Vanessa M McMahan, Sybill G Hosek, K Rivet Amico, Aminta Kouyate, Hailey J Gilmore, Susan P Buchbinder, Richard T Lester, Robert M Grant, Albert Y Liu
Preexposure prophylaxis is a highly protective HIV prevention strategy, yet nonadherence can significantly reduce its effectiveness. We conducted a mixed methods evaluation of a mobile health intervention (iText) that utilized weekly bidirectional text or e-mail support messages to encourage preexposure prophylaxis (PrEP) adherence among participants in the multi-site iPrEx open-label extension study. A convenience sample of PrEP users from the San Francisco and Chicago sites participated in a 12-week pilot study...
March 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29554663/hiv-incidence-hiv-prevalence-and-undiagnosed-hiv-infections-in-men-who-have-sex-with-men-united-states
#5
Sonia Singh, Ruiguang Song, Anna Satcher Johnson, Eugene McCray, H Irene Hall
Background: HIV infection is a persistent health concern in the United States, and men who have sex with men (MSM) continue to be the most affected population. Objective: To estimate HIV incidence and prevalence and the percentage of undiagnosed HIV infections overall and among MSM. Design: Cross-sectional analysis. Setting: National HIV Surveillance System. Participants: Persons aged 13 years and older with diagnosed HIV infection...
March 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29474256/correlates-of-linkage-to-hiv-preexposure-prophylaxis-among-hiv-testing-clients
#6
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV-testing sites can identify HIV preexposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV-testing program, and HIV-prevention program (HPP) in Houston, TX, a high HIV-incidence city. METHODS: A prospective assessment of individuals aged 18 years and older recruited from walk-in HIV testing from December 2013 to April 2015 included risk assessment, HIV testing, and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
April 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29472966/a-preliminary-study-of-the-attitudes-and-barriers-of-family-physicians-to-prescribing-hiv-preexposure-prophylaxis
#7
Nicholas Ojile, Donna Sweet, K James Kallail
Introduction: Attitudes of individuals who provide HIV care towards prescribing Preexposure Prophylaxis (PrEP) to at-risk populations have been studied, but few studies indicate if family physicians would be willing to prescribe PrEP as most family physicians do not specialize in HIV medicine. Few data exist on the perceived barriers preventing family physicians from prescribing PrEP. The purpose of this project was to assess the attitudes and perceived barriers of family physicians in Kansas towards prescribing PrEP to high risk patient populations...
May 2017: Kansas Journal of Medicine
https://www.readbyqxmd.com/read/29471706/-where-did-this-prep-come-from-african-american-mother-daughter-perceptions-related-to-adolescent-preexposure-prophylaxis-prep-utilization-and-clinical-trial-participation
#8
Faith E Fletcher, Celia Fisher, Meredith K Buchberg, Brenikki Floyd, Anna Hotton, Angelica Ehioba, Geri Donenberg
Despite the demonstrated effectiveness of preexposure prophylaxis (PrEP) to reduce incident HIV infections, PrEP's potential as an HIV prevention strategy for adolescent populations is unknown. This study assessed perceptions of adolescent PrEP use and clinical trial participation among African American women and their adolescent daughters. We conducted focus group discussions with 15 African American mother/daughter pairs ( N = 30). Findings suggest a general lack of PrEP awareness, favorable attitudes toward adolescent PrEP use, altruistic attitudes regarding research participation among daughters, and less favorable attitudes toward adolescent clinical trial participation among mothers...
February 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29461330/sexual-and-reproductive-health-in-hiv-positive-adolescents
#9
Lisa Hamzah, Elizabeth Hamlyn
PURPOSE OF REVIEW: This review aims to summarize data in the last 18 months on the sexual and reproductive health of perinatally and horizontally infected adolescents and young people living with HIV (age 13-25 years) and to highlight some key issues faced by this group of adolescents as they reach puberty and sexual debut. RECENT FINDINGS: Adolescents and young people living with HIV are a growing cohort worldwide and a significant proportion engage in high-risk sexual activity, pose risk of onward HIV transmission, yet have poor access to sexual and reproductive health (SRH) services and lack the knowledge and support to advocate for their needs...
February 15, 2018: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29433965/hiv-preexposure-prophylaxis-an-essential-safe-and-effective-prevention-tool-for-sexual-health
#10
M Siguier, J-M Molina
Preexposure prophylaxis of HIV with antiretroviral drugs is a prevention tool available in France since 2016, combined with the prevention methods already used (condoms, post-exposure treatment, rapid treatment of diagnosed HIV infections, etc.). It is targeted at populations at high risk of HIV infection, especially men who have sex with men, for whom traditional prevention methods are insufficient. We collected clinical research data, which resulted in the launch of preexposure prophylaxis in the United States and then elsewhere in the world, safety, tolerability and cost data, as well as ongoing research data (new molecules/methods of administration)...
February 9, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29424774/in-what-circumstances-could-nondaily-preexposure-prophylaxis-for-hiv-substantially-reduce-program-costs
#11
Kate M Mitchell, Dobromir Dimitrov, James P Hughes, Fan Xia, Deborah Donnell, K Rivet Amico, Kevin Bokoch, Anupong Chitwarakorn, Linda-Gail Bekker, Timothy H Holtz, Sharon Mannheimer, Robert M Grant, Marie-Claude Boily
OBJECTIVES: To review the main factors influencing the costs of nondaily oral preexposure prophylaxis (PrEP) with tenofovir (±emtricitabine). To estimate the cost reductions possible with nondaily PrEP compared with daily PrEP for different populations (MSM and heterosexual populations). DESIGN: Systematic review and data triangulation. METHODS: We estimated the required number of tablets/person/week for dosing regimens used in the HPTN 067/ADAPT (daily/time-driven/event-driven) and IPERGAY (on-demand) trials for different patterns of sexual intercourse...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29420695/daily-and-nondaily-oral-preexposure-prophylaxis-in-men-and-transgender-women-who-have-sex-with-men-the-human-immunodeficiency-virus-prevention-trials-network-067-adapt-study
#12
Robert M Grant, Sharon Mannheimer, James P Hughes, Yael Hirsch-Moverman, Avelino Loquere, Anupong Chitwarakorn, Marcel E Curlin, Maoji Li, K Rivet Amico, Craig W Hendrix, Peter L Anderson, Bonnie J Dye, Mark A Marzinke, Estelle Piwowar-Manning, Laura McKinstry, Vanessa Elharrar, Michael Stirratt, James F Rooney, Susan H Eshleman, Janet M McNicholl, Frits van Griensven, Timothy H Holtz
Background: Nondaily dosing of oral preexposure prophylaxis (PrEP) may provide equivalent coverage of sex events compared with daily dosing. Methods: At-risk men and transgender women who have sex with men were randomly assigned to 1 of 3 dosing regimens: 1 tablet daily, 1 tablet twice weekly with a postsex dose (time-driven), or 1 tablet before and after sex (event-driven), and were followed for coverage of sex events with pre- and postsex dosing measured by weekly self-report, drug concentrations, and electronic drug monitoring...
February 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29381558/care-continuum-entry-interventions-seek-and-test-strategies-to-engage-persons-most-impacted-by-hiv-within-the-united-states
#13
Moira C McNulty, John A Schneider
: The current review re-conceptualizes seek and test strategies, particularly given the changing importance of HIV testing as care continuum entry for persons irrespective of their HIV status. Care continuum entry advances previous seek and test strategies for client engagement with two next-generation functions: use of testing to engage (or re-engage) HIV negative clients in preexposure prophylaxis (PrEP) care; and testing individuals who may already be known positives for care continuum re-entry. We review existing seek and test strategies for most impacted community members with a goal of optimizing care continuum entry as we move towards HIV transmission elimination...
February 20, 2018: AIDS
https://www.readbyqxmd.com/read/29370356/moving-forward-with-treatment-of-gonorrhea-for-users-of-hiv-preexposure-prophylaxis-given-the-threat-of-antimicrobial-resistance
#14
Samuel M Jenness, Kevin M Weiss, Steven M Goodreau, Thomas Gift, Harrell Chesson, Karen W Hoover, Dawn K Smith, Albert Y Liu, Patrick S Sullivan, Eli S Rosenberg
No abstract text is available yet for this article.
January 23, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29358160/awareness-of-prevention-strategies-and-willingness-to-use-preexposure-prophylaxis-in-brazilian-men-who-have-sex-with-men-using-apps-for-sexual-encounters-online-cross-sectional-study
#15
Thiago Silva Torres, Raquel Brandini De Boni, Mauricio Tl de Vasconcellos, Paula Mendes Luz, Brenda Hoagland, Ronaldo Ismerio Moreira, Valdilea Gonçalves Veloso, Beatriz Grinsztejn
BACKGROUND: Geosocial networking (GSN) smartphone apps are becoming the main venue for sexual encounters among Brazilian men who have sex with men (MSM). To address the increased HIV incidence in this population, preexposure prophylaxis (PrEP) was recently implemented in the Brazilian public health system in the context of combined HIV prevention. OBJECTIVE: This study aimed to describe the characteristics of MSM using GSN apps for sexual encounters, their awareness of prevention strategies, and willingness to use PrEP...
January 22, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29353546/who-starts-the-conversation-and-who-receives-preexposure-prophylaxis-prep-a-brief-online-survey-of-medical-providers-prep-practices
#16
Leah M Adams, Benjamin H Balderson, Kathy Brown, Staci E Bush, Bruce J Packett
Uptake of preexposure prophylaxis (PrEP) has been slow, but is increasing. Although PrEP is indicated for many patients, it has been concentrated among men who have sex with men (MSM). Awareness of PrEP is limited among non-MSM individuals, and among some MSM. As such, individuals at risk for HIV who are unaware of PrEP must rely on their medical providers to initiate conversations about PrEP. Members of a national professional organization of HIV specialists with prescribing privileges, including physicians, nurse practitioners, and physician assistants, participated in an online survey ( n = 342) to characterize their PrEP prescribing behaviors and the demographic membership of their PrEP patients...
January 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29324178/sex-venue-based-network-analysis-to-identify-hiv-prevention-dissemination-targets-for-men-who-have-sex-with-men
#17
Rupa R Patel, Douglas A Luke, Enola K Proctor, William G Powderly, Philip A Chan, Kenneth H Mayer, Laura C Harrison, Amar Dhand
PURPOSE: The aim of this study was to identify sex venue-based networks among men who have sex with men (MSM) to inform HIV preexposure prophylaxis (PrEP) dissemination efforts. METHODS: Using a cross-sectional design, we interviewed MSM about the venues where their recent sexual partners were found. Venues were organized into network matrices grouped by condom use and race. We examined network structure, central venues, and network subgroups. RESULTS: Among 49 participants, the median age was 27 years, 49% were Black and 86% reported condomless anal sex (ncAS)...
January 2018: LGBT Health
https://www.readbyqxmd.com/read/29323558/optimizing-delivery-of-hiv-preexposure-prophylaxis-for-women-in-the-united-states
#18
Erika Aaron, Cori Blum, Dominika Seidman, Mary Jo Hoyt, Joanne Simone, Meg Sullivan, Dawn K Smith
Preexposure prophylaxis (PrEP) is a highly effective HIV prevention method; however, it is underutilized among women who are at risk for acquisition of HIV. Women comprise one in five HIV diagnoses in the United States, and significant racial disparities in new HIV diagnoses persist. The rate of new HIV diagnoses among black and African American women in 2015 was 16 times greater than that of white women. These disparities highlight the importance of HIV prevention strategies for women, including the use of PrEP...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29278542/potential-kidney-toxicity-from-the-antiviral-drug-tenofovir-new-indications-new-formulations-and-a-new-prodrug
#19
Lili Chan, Benjamin Asriel, Ellen F Eaton, Christina M Wyatt
PURPOSE OF REVIEW: The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also a component of daily preexposure prophylaxis (PrEP) to reduce the risk of HIV infection in high-risk populations. Although TDF is well tolerated, the potential for kidney and bone toxicity has important implications for public health given the large number of individuals exposed to TDF worldwide...
March 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29274655/do-you-prep-a-review-of-primary-care-provider-knowledge-of-prep-and-attitudes-on-prescribing-prep
#20
Leah Turner, Abbey Roepke, Emily Wardell, Anne M Teitelman
Oral preexposure prophylaxis (PrEP) has been proven to be a safe and effective means of preventing HIV. The purpose of our literature review was to examine primary care provider knowledge and attitudes about prescribing PrEP. PubMed, CINAHL, Web of Science, and Scopus were searched and additional articles were identified through other sources, yielding 11 articles that met inclusion criteria. Overall, there was high variability among providers regarding attitudes, knowledge, and prescriptive practices related to PrEP...
January 2018: Journal of the Association of Nurses in AIDS Care: JANAC
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