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Mast cell asthma

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https://www.readbyqxmd.com/read/28514622/mast-cells-and-kit-as-potential-therapeutic-targets-in-severe-asthma
#1
EDITORIAL
Stephen J Galli
New England Journal of Medicine, Volume 376, Issue 20, Page 1983-1984, May 2017.
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28514613/kit-inhibition-by-imatinib-in-patients-with-severe-refractory-asthma
#2
RANDOMIZED CONTROLLED TRIAL
Katherine N Cahill, Howard R Katz, Jing Cui, Juying Lai, Shamsah Kazani, Allison Crosby-Thompson, Denise Garofalo, Mario Castro, Nizar Jarjour, Emily DiMango, Serpil Erzurum, Jennifer L Trevor, Kartik Shenoy, Vernon M Chinchilli, Michael E Wechsler, Tanya M Laidlaw, Joshua A Boyce, Elliot Israel
BACKGROUND: Mast cells are present in the airways of patients who have severe asthma despite glucocorticoid treatment; these cells are associated with disease characteristics including poor quality of life and inadequate asthma control. Stem cell factor and its receptor, KIT, are central to mast-cell homeostasis. We conducted a proof-of-principle trial to evaluate the effect of imatinib, a KIT inhibitor, on airway hyperresponsiveness, a physiological marker of severe asthma, as well as on airway mast-cell numbers and activation in patients with severe asthma...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28483562/the-role-of-inkt-cells-on-the-phenotypes-of-allergic-airways-in-a-mouse-model
#3
Lennart K A Lundblad, Nazey Gülec, Matthew E Poynter, Victoria L DeVault, Oliver Dienz, Jonathan E Boyson, Nirav Daphtary, Minara Aliyeva, Jennifer L Ather, Felix Scheuplein, Robert Schaub
iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperresponsiveness (AHR) to agents such as methacholine. However, a mechanistic link between iNKT cells and mast cell recruitment or activation has never been explored. Our objective was to determine whether iNKT cells are necessary for the recruitment of mast cells and if iNKT cells can influence the acute allergen induced bronchoconstriction (AIB) caused by mast cell mediator release...
May 5, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28477184/il-9-function-sources-and-detection
#4
Wilmer Gerardo Rojas-Zuleta, Elizabeth Sanchez
IL-9 is a pleiotropic cytokine produced in different amounts by a wide variety of cells including mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells. Th9 cells are considered to be the main CD4+ T cells that produce IL-9. IL-9 exerts its effects on multiple types of cells and different tissues. To date, its main role has been found in the immune responses against parasites and pathogenesis of allergic diseases such as asthma and bronchial hyperreactivity. Additionally, it induces the proliferation of hematologic neoplasias, including Hodgkin's lymphoma in humans...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28474352/airway-basophils-are-increased-and-activated-in-eosinophilic-asthma
#5
Yoshihiro Suzuki, Keiko Wakahara, Tomoko Nishio, Satoru Ito, Yoshinori Hasegawa
BACKGROUND: The impact of basophils on asthma pathogenesis remains largely unexplored, particularly in humans. Here, we evaluated the frequencies and activation status of basophils in the sputum of adult asthmatic patients and related our findings to other parameters of eosinophilic airway inflammation. METHODS: We enrolled 44 adult asthmatic patients who were being treated with inhaled corticosteroids (ICS). Analysis of the induced sputum, exhaled nitric oxide fraction (FeNO) measurement, and Asthma Control Test (ACT) were carried out together with standard blood and pulmonary function tests...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28463786/innate-immunity-as-the-orchestrator-of-allergic-airway-inflammation-and-resolution-in-asthma
#6
REVIEW
Despoina Thiriou, Ioannis Morianos, Georgina Xanthou, Konstantinos Samitas
The respiratory system is constantly in direct contact with the environment and, has therefore, developed strong innate and adaptive immune responses to combat pathogens. Unlike adaptive immunity which is mounted later in the course of the immune response and is naive at the outset, innate immunity provides the first line of defense against microbial agents, while also promoting resolution of inflammation. In the airways, innate immune effector cells mainly consist of eosinophils, neutrophils, mast cells, basophils, macrophages/monocytes, dendritic cells and innate lymphoid cells, which attack pathogens directly or indirectly through the release of inflammatory cytokines and antimicrobial peptides, and coordinate T and B cell-mediated adaptive immunity...
April 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28458281/role-of-histamine-releasing-factor-in-allergic-inflammatory-reactions
#7
Jun-Ichi Kashiwakura, Tomoaki Ando, Toshiaki Kawakami
 Mast cells are effector cells in immunoglobulin E (IgE)-mediated immediate hypersensitivity and allergic diseases such as asthma and food allergy. Mast cells are activated by the aggregation of the IgE-bound high-affinity IgE receptor FcεRI with multivalent antigen. Activated mast cells secrete proinflammatory mediators such as histamine, serotonin, and proteases and produce cytokines and chemokines. However, it has been reported that mast cells are activated by crosslinking of FcεRI with monomeric IgE in the absence of antigen...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28449552/effect-of-proparacaine-in-a-mouse-model-of-allergic-rhinitis
#8
Hwan Soo Kim, Sulmui Won, Eu Kyoung Lee, Yoon Hong Chun, Jong-Seo Yoon, Jin Tack Kim, Hyun Hee Kim
Objectives: Lidocaine, a local anaesthetic is a treatment option in uncontrolled asthma due to its immunomodulatory effects. In the present study, proparacaine (PPC), a derivative of lidocaine was examined for its therapeutic application in a mouse model of allergic rhinitis. Methods: The mice were grouped into 4 groups: control group, allergic rhinitis (AR) group, ciclesonide (CIC) group, and PPC group. Nasal symptom scores, eosinophil counts, goblet cell counts, and mast cells counts in the nasal mucosa were measured...
April 28, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28447503/1-6-o-o-diacetylbritannilactone-suppresses-activation-of-mast-cell-and-airway-hyper-responsiveness
#9
Meihua Jin, Sungun Kim, Nan Qin, Xi Chen, Ning Ji, Sheng-An Tang, Dexin Kong, Eunkyung Lee, Hongquan Duan
Mast cells play critical roles in allergic disorders such as atopic dermatitis and allergic asthma. The aim of this study was to investigate the anti-inflammatory and anti-asthmatic activities of 1,6-O,O-diacetylbritannilactone (OODBL) isolated from Inula japonica Thunb. (I. japonica) in a murine asthma model and bone marrow-derived mast cells (BMMCs). In an ovalbumin-induced asthma model, OODBL administration attenuated the airway hyper-responsiveness induced by aerosolized methacholine and serum IgE level in asthmatic mice...
April 27, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28417574/light-emitting-diode-treatment-ameliorates-allergic-lung-inflammation-in-experimental-model-of-asthma-induced-by-ovalbumin
#10
Vanessa Perosino Cardoso Siqueira, Marina Izadora Silveira Evangelista, Alana Dos Santos, Rodrigo Labat Marcos, Ana Paula Ligeiro-de-Oliveira, Christiane Pavani, Amílcar Sabino Damazo, Adriana Lino-Dos-Santos-Franco
Since asthma is a multifactorial disease where treatment sometimes is not effective, new therapies that improve the respiratory discomfort of patients are of great importance. Phototherapy as Light-emitting diode (LED) has emerged as a treatment that presents good results for diseases that are characterized by inflammation. Thus, our objective was to investigate the effects of LED on lung inflammation, by an evaluation of lung cell infiltration, mucus secretion, oedema, and the production of cytokines. Male Balb/c mice were or not sensitized and challenged with ovalbumin (OVA) and treated or not with LED therapy (1 h and 4 h after each OVA challenge)...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28413317/korean-red-ginseng-improves-atopic-dermatitis-like-skin-lesions-by-suppressing-expression-of-proinflammatory-cytokines-and-chemokines-in%C3%A2-vivo-and-in%C3%A2-vitro
#11
Ji-Ye Kee, Yong-Deok Jeon, Dae-Seung Kim, Yo-Han Han, Jinbong Park, Dong-Hyun Youn, Su-Jin Kim, Kwang Seok Ahn, Jae-Young Um, Seung-Heon Hong
BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28408397/the-il-31-il-31-receptor-axis-general-features-and-role-in-tumor-microenvironment
#12
REVIEW
Elisa Ferretti, Anna Corcione, Vito Pistoia
IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M R. Signaling through the IL-31R involves the MAPK, PI3K/AKT and Jak/STAT pathways. Different variants and isoforms of IL-31RA with different signaling activities have been identified. IL-31 is produced predominantly by circulating Th2 lymphocytes and skin-homing CLA(+)CD45RO(+) T cells...
April 13, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28399855/characterisation-of-a-murine-model-of-the-late-asthmatic-response
#13
Katie Baker, Kristof Raemdonck, Robert J Snelgrove, Maria G Belvisi, Mark A Birrell
BACKGROUND: The incidence of asthma is increasing at an alarming rate. While the current available therapies are effective, there are associated side effects and they fail to adequately control symptoms in all patient subsets. In the search to understand disease pathogenesis and find effective therapies hypotheses are often tested in animal models before progressing into clinical studies. However, current dogma is that animal model data is often not predictive of clinical outcome. One possible reason for this is the end points measured such as antigen-challenge induced late asthmatic response (LAR) is often used in early clinical development, but seldom in animal model systems...
April 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28397727/neutralization-of-interleukin-9-decreasing-mast-cells-infiltration-in-experimental-autoimmune-encephalomyelitis
#14
Jun-Jie Yin, Xue-Qiang Hu, Zhi-Feng Mao, Jian Bao, Wei Qiu, Zheng-Qi Lu, Hao-Tian Wu, Xiao-Nan Zhong
BACKGROUND: Th9 cells are a newly discovered CD4+ T helper cell subtype, characterized by high interleukin (IL)-9 secretion. Growing evidences suggest that Th9 cells are involved in the pathogenic mechanism of multiple sclerosis (MS). Mast cells are multifunctional innate immune cells, which are perhaps best known for their role as dominant effector cells in allergies and asthma. Several lines of evidence point to an important role for mast cells in MS and its animal models. Simultaneously, there is dynamic "cross-talk" between Th9 and mast cells...
April 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28382037/influenza-infection-in-mice-induces-accumulation-of-lung-mast-cells-through-the-recruitment-and-maturation-of-mast-cell-progenitors
#15
Behdad Zarnegar, Erika Mendez-Enriquez, Annika Westin, Cecilia Söderberg, Joakim S Dahlin, Kjell-Olov Grönvik, Jenny Hallgren
Mast cells (MCs) are powerful immune cells that mature in the peripheral tissues from bone marrow (BM)-derived mast cell progenitors (MCp). Accumulation of MCs in lung compartments where they are normally absent is thought to enhance symptoms in asthma. The enrichment of lung MCs is also observed in mice subjected to models of allergic airway inflammation. However, whether other types of lung inflammation trigger increased number of MCp, which give rise to MCs, is unknown. Here, mouse-adapted H1N1 influenza A was used as a model of respiratory virus infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28359265/tonggyu-tang-a-traditional-korean-medicine-suppresses-pro-inflammatory-cytokine-production-through-inhibition-of-mapk-and-nf-%C3%AE%C2%BAb-activation-in-human-mast-cells-and-keratinocytes
#16
Hyo In Kim, Se Hyang Hong, Jin Mo Ku, Sooyeon Kang, Tai Young Kim, Yong Cheol Shin, Seong-Gyu Ko
BACKGROUND: Allergic diseases including allergic rhinitis, asthma, and atopic dermatitis are increasing worldwide. Common medications used to treat these inflammatory disorders are anti-histamines and corticosteroids, but they have their own limitations such as short duration and severe side effects. Thus, interest in complementary and alternative medicine is continually growing. Here, we investigate the anti-inflammatory mechanisms of Tonggyu-tang (TGT), a traditional Korean medicine that has been used to treat patients with allergic nasal disorders...
March 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28352305/from-bench-to-bedside-therapeutic-potential-of-interleukin-9-in-the-treatment-of-asthma
#17
Fang Gong, Yu-Hong Pan, Xuan Huang, Hua-Yan Zhu, Dong-Lin Jiang
Initially identified as a T cell and mast cell growth factor, interleukin (IL)-9 has long been recognized as an important mediator of asthma. Recently, accumulating results from transgenic mice demonstrated that systemic or lung-specific overexpression of IL-9 caused asthma-associated symptoms. Moreover, anti-mIL-9 antibody (Ab) blocking treatment alleviated disease in animal models of asthma. In light of the large quantity of data from the murine models, MEDI-528, a humanized anti-IL-9 monoclonal Ab has been produced to assess the activity of IL-9 on human asthma...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28343320/allergic-airway-inflammation-induces-migration-of-mast-cell-populations-into-the-mouse-airway
#18
David Schmit, Duc Dung Le, Sebastian Heck, Markus Bischoff, Thomas Tschernig, Christian Herr, Christoph Beisswenger, Peter Kobelt, Phillipp Moritz Lepper, Kian Fan Chung, Robert Bals, Quoc Thai Dinh
Mast cells (MCs) and airway nerves play an important role in allergic asthma. However, little is known about the MCs and their interaction with airway nerves during allergic airway inflammation. This study aims to investigate the distribution and proliferation of MC populations in different lung compartments, along with the association of mast cells with nerve endings, using a house dust mite (HDM) model for allergic airway inflammation. BALB/c mice were exposed to HDM extract intranasally (25 μg/50 μl) for 5 consecutive days a week over 7 weeks...
March 25, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28293189/investigation-into-the-role-of-pi3k-and-jak3-kinase-inhibitors-in-murine-models-of-asthma
#19
Akshaya D Wagh, Manoranjan Sharma, Jogeshwar Mahapatra, Abhijeet Chatterjee, Mukul Jain, Veeranjaneyulu Addepalli
Asthma is a clinical disorder commonly characterized by chronic eosinophilic inflammation, remodeling and hyper responsiveness of the airways. However, the kinases like Phosphoinositide 3 kinase (PI3K) and Janus kinase 3 (JAK3) are involved in mast cell proliferation, activation, recruitment, migration, and prolonged survival of inflammatory cells. The present study was designed to evaluate the in-vivo comparative effects of two kinase inhibitors on airway inflammation and airway remodeling in acute and chronic models of asthma...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28266165/il33-and-il1rl1-variants-are-associated-with-asthma-and-atopy-in-a-brazilian-population
#20
G A Queiroz, R S Costa, N M Alcantara-Neves, G Nunes de Oliveira Costa, M L Barreto, V L Carneiro, C A Figueiredo
Atopic asthma is a chronic inflammatory disease in airways resulting from genetic and environmental factors, characterized by production of the Th2 cytokines interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-13 (IL-13). Interleukin-33 (IL-33) appears to be a potent inducer of Th2 immune response. This occurs when IL-33 binds and activates its receptor, the membrane ST2 (ST2L) in mast cells, dendritic cells, basophils, eosinophils, innate lymphoids and Th2 cells, leading to the release of these cytokines and intensifying allergic inflammation...
April 2017: International Journal of Immunogenetics
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