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https://www.readbyqxmd.com/read/29348572/areca-nut-extracts-mobilize-calcium-and-release-pro-inflammatory-cytokines-from-various-immune-cells
#1
Malika Faouzi, Ram P Neupane, Jian Yang, Philip Williams, Reinhold Penner
Betel nut consumption has significant implications for the public health globally, as the wide-spread habit of Areca chewing throughout Asia and the Pacific is associated with a high prevalence of oral carcinoma and other diseases. Despite a clear causal association of betel nut chewing and oral mucosal diseases, the biological mechanisms that link Areca nut-contained molecules, inflammation and cancer remain underexplored. In this study we show that the whole Areca nut extract (ANE) is capable of mobilizing Ca2+ in various immune cell lines...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344321/fixed-drug-eruption-to-supplement-containing-ginkgo-biloba-and-vinpocetine-a-case-report-and-review-of-related-cutaneous-side-effects
#2
Philip R Cohen
BACKGROUND: Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. Ginkgo biloba leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. PURPOSE: To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing Ginkgo biloba and vinpocetine...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29341916/effects-of-surfactant-based-permeation-enhancers-on-mannitol-permeability-histology-and-electrogenic-ion-transport-responses-in-excised-rat-colonic-mucosae
#3
Sam Maher, Joanne Heade, Fiona McCartney, Seona Waters, Sinéad B Bleiel, David J Brayden
Surfactant-based intestinal permeation enhancers (PEs) are constituents of several oral macromolecule formulations in clinical trials. This study examined the interaction of a test panel of surfactant-based PEs with isolated rat colonic mucosae mounted in Ussing chambers in an attempt to determine if increases in transepithelial permeability can be separated from induction of mucosal perturbation. The aim was to assess the effects of PEs on (i) apparent permeability coefficient (Papp) of [14C]-mannitol on (ii) histology score and (iii) short-circuit current (ΔIsc) responses to a cholinomimetic (carbachol, CCh)...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29338834/advances-in-tissue-engineered-oral-mucosa
#4
Fan Hao Meng, Xiao Lin Shao, Yu Song, Tao Zhang
The large defect of oral and maxillofacial region doesn't only affect the function and aesthetics but also has an adverse impact on patients' psychology. The traditional way to restore the defects are limited by donor site and secondary trauma. In recent years,the oral mucosal tissue engineering has developed rapidly and provides a new solution for craniofacial reconstruction. Tissue-engineered oral mucosa is an ideal substitute of oral mucosa. It can be used in clinical settings and in vitro experiments. This articles review the recent advances in tissue-engineered oral mucosa and its applications...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29338309/oral-microbiota-reduce-wound-healing-capacity-of-epithelial-monolayers-irrespective-of-the-presence-of-5-fluorouracil
#5
Eline Vanlancker, Barbara Vanhoecke, Tom Sieprath, Janie Bourgeois, Annelore Beterams, Barbara De Moerloose, Winnok H De Vos, Tom Van de Wiele
Oral mucositis is still one of the most painful side effects of chemotherapeutic treatment and a mounting body of evidence suggests a key role for the oral microbiome in mucositis development. However, the underlying mechanisms remain elusive. In this work, we have investigated the interactions between the host, the microbiome, and chemotherapeutic treatments in more detail. The effect of 5-fluorouracil, commonly inducing mucositis, was assessed on a co-culture model that consists of an epithelial cell layer and a biofilm derived from oral microbiota from different types of samples (saliva, buccal swabs and tongue swabs) and donors (healthy individuals and patients suffering from mucositis)...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29338018/oral-mucosa-tissue-gene-expression-profiling-before-during-and-after-radiation-therapy-for-tonsil-squamous-cell-carcinoma
#6
Mette Marcussen, Mads Sønderkær, Julie Støve Bødker, Maria Andersen, Søren Nielsen, Charles Vesteghem, Ilse Christiansen, Olav Jonas Bergmann, Martin Bøgsted, Karen Dybkær, Mogens Vyberg, Hans Erik Johnsen
BACKGROUND: Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests. In this pilot study, we applied global gene-expression analysis on serial human oral mucosa tissue and blood cells from patients with tonsil squamous cell cancer (TSCC) to identify genes involved in mucositis pathogenesis. METHODS AND FINDINGS: Eight patients with TSCC each provided consecutive buccal biopsies and blood cells before, after 7 days of RT treatment, and 20 days following RT...
2018: PloS One
https://www.readbyqxmd.com/read/29337392/oral-health-related-concerns-behavior-and-communication-with-health-care-providers-of-patients-with-breast-cancer-impact-of-different-treatments
#7
L Susan Taichman, Catherine H Van Poznak, Marita R Inglehart
AIM: The objectives are to compare responses of breast cancer (BCa) treatment groups (chemotherapy, tamoxifen, and aromatase inhibitors (AIs) to each other and a control regarding (a) subjective oral health, (b) oral health-related behaviors, (c) oral health-related concerns, and (d) communication with health care providers. METHODS: Survey data were collected from 140 postmenopausal BCa patients and 41 healthy postmenopausal control respondents. RESULTS: BCa patients reported on average more frequent mouth sores/mucositis (5-point scale with 1 = never: 1...
January 16, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29335689/psoriasis-a-review-of-systemic-comorbidities-and-dental-management-considerations
#8
John K Brooks
OBJECTIVE: There is a growing body of evidence to substantiate that cutaneous psoriasis is associated with an increased risk for a multitude of systemic disorders. Although there is an extensive array of medical publications regarding psoriasis, the dental literature has almost exclusively been focused on erythema migrans and occasionally, with oral psoriatic mucositis, chronic periodontitis, and psoriatic arthritis of the temporomandibular joint. This report will review the diversity of systemic comorbidities, namely cardiovascular, neurologic, renal, liver, gastrointestinal, pulmonary, endocrine, ocular, arthritic (including temporomandibular joint), nail, cutaneous, and psychologic (including suicide) disorders; neoplasia; infection; dyslipidemia; vitamin D deficiency; substance abuse; higher mortality; and oral mucosal involvement...
January 15, 2018: Quintessence International
https://www.readbyqxmd.com/read/29335684/association-between-self-perceived-oral-health-and-clinical-indicators
#9
Janet-Ofelia Guevara-Canales, Rafael Morales-Vadillo, Sonia-Julia Sacsaquispe-Contreras, Dora-Erika Alberca-Ramos, Hans Morgenstern-Orezzoli, Carlos-Enrique Cava-Vergiú
PURPOSE: To determine whether self-perceived oral health impact and satisfaction measure oral health in the same way as do clinical indicators in adults and older adults. MATERIALS AND METHODS: The population consisted of adult patients aged 20 to 59 years receiving care at "Juan Pablo II" Health Care Centre and older adult patients aged 60 or more years from the home for the elderly "Virgen del Amor Hermoso", Lima, Peru. The indices Oral Impacts on Daily Performance (OIDP) and Oral Satisfaction Scale of 0-10 (OSS 0-10) were used to evaluate perceived impact of and satisfaction with oral health...
January 15, 2018: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/29335479/lps-induced-vitamin-d-receptor-decrease-in-oral-keratinocytes-is-associated-with-oral-lichen-planus
#10
Bin Zhao, Ran Li, Fang Yang, Feiyan Yu, Na Xu, Fang Zhang, Xuejun Ge, Jie Du
The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. In human specimen studies, VDR levels of oral mucosal epithelia from OLP patients decreased substantially accompanied with robust TNFα and miR-346 induction, compared to the normal tissues...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334299/mucoadhesive-buccal-film-containing-ornidazole-and-dexamethasone-for-oral-ulcers-in-vitro-and-in-vivo-studies
#11
Chengliang Zhang, Yanan Liu, Wei Li, Ping Gao, Dong Xiang, Xiuhua Ren, Dong Liu
A bilayered mucoadhesive buccal film containing a combination of ornidazole (OD) and dexamethasone sodium phosphate (DEX) was prepared using solvent casting to treat oral ulcers. Films were systematically evaluated in vitro to obtain the optimum formulation. The therapeutic effects of these films were investigated in the rabbit oral ulcer model and the in vivo release of OD and DEX in the human oral cavity was also evaluated. The backing layer contained ethyl cellulose and an optimal mucoadhesive layer containing both OD and DEX was produced...
January 15, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29331830/fetal-development-of-the-poeppig-s-woolly-monkey-lagothrix-poeppigii
#12
Rafael Dos Santos de Andrade, Frederico Ozanan Barros Monteiro, Hani Rocha El Bizri, Wilter Ricardo Russiano Vicente, Diva Anelie de Araujo Guimarães, Pedro Mayor
The intrauterine development is an evolutionary strategy that prepares the neonate for extra-uterine life, thus providing important information on the life history of species. In this study, we described the external and internal morphology of 25 fetuses of Poeppig's woolly monkeys (Lagothrix poeppigii) by taking advantage of a 10-year participatory collection of biological samples originated from animals hunted for subsistence purposes in the Peruvian Amazon. Logistic regressions estimated the probability of occurrence of each external morphological characteristic in relation to the crown-rump length (CRL)...
December 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29331021/onset-progression-and-resolution-of-experimental-peri-implant-mucositis-at-different-abutment-surfaces-a-randomized-controlled-two-center-study
#13
F Schwarz, J Becker, C Sara, D Hazar, T Iglhaut, G Iglhaut
OBJECTIVES: To assess the onset, progression and resolution of experimentally induced peri-implant mucositis lesions at abutments with different microstructures in humans. MATERIAL & METHODS: In a randomized, controlled, interventional two-center study, a total of 28 patients had received 28 target implants and were randomly allocated to either partially microgrooved- (test) or machined (control) healing abutments. The study was accomplished in 3 phases, including a wound healing period (WH) following implant placement (12 weeks), a plaque exposure phase (EP - 21 days) and a resolution phase (RP - 16 weeks)...
January 13, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29330512/inactivated-rotavirus-vaccine-by-parenteral-administration-induces-mucosal-immunity-in-mice
#14
Theresa K Resch, Yuhuan Wang, Sung-Sil Moon, Jessica Joyce, Song Li, Mark Prausnitz, Baoming Jiang
To improve the safety and efficacy of oral rotavirus vaccines, we developed an inactivated rotavirus vaccine (IRV) for parenteral administration. Since it remains unknown whether parenteral vaccination can induce mucosal immunity, we performed a comprehensive assessment of immune responses to IRV in mice with an adjuvant-free dissolving polymer MN patch or by alum-adjuvanted IM injection. We demonstrated that IRV induced the expression of the gut homing receptor LPAM-1 on T and B cells in spleen and mLN of vaccinated mice...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329683/respiratory-disease-in-ball-pythons-python-regius-experimentally-infected-with-ball-python-nidovirus
#15
Laura L Hoon-Hanks, Marylee L Layton, Robert J Ossiboff, John S L Parker, Edward J Dubovi, Mark D Stenglein
Circumstantial evidence has linked a new group of nidoviruses with respiratory disease in pythons, lizards, and cattle. We conducted experimental infections in ball pythons (Python regius) to test the hypothesis that ball python nidovirus (BPNV) infection results in respiratory disease. Three ball pythons were inoculated orally and intratracheally with cell culture isolated BPNV and two were sham inoculated. Antemortem choanal, oroesophageal, and cloacal swabs and postmortem tissues of infected snakes were positive for viral RNA, protein, and infectious virus by qRT-PCR, immunohistochemistry, western blot and virus isolation...
January 9, 2018: Virology
https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#16
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29327722/healthy-lifestyle-habits-benefit-remission-of-recurrent-aphthous-stomatitis-and-ras-type-ulceration
#17
L Ge
In a clinical setting, it is not practical to separate recurrent aphthous stomatitis (RAS) from RAS-type ulceration in every case, so both conditions have been considered together for the purpose of this article. Due to the lack of consistently effective therapeutic options for RAS, other approaches to treat the disease are considered here, beginning with an analysis of possible aetiological factors. The aetiology of RAS, the most common mucosal disease, remains undefined thus far. A few researchers have proposed psychological disorders as a major factor impacting RAS...
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29325767/primary-synovial-sarcoma-arising-from-gingivo-buccal-sulcus-harbouring-ss18-ssx2-positive-fusion-transcript-the-1st-reported-case-in-english-literature
#18
Tanush Vig, Meera Thomas, Rekha Pai, Amit Jiwan Tirkey, Rajnikanth Janakiraman
Synovial sarcoma (SS) is a mesenchymal tumour of uncertain histiogenesis that can show dual epithelial and mesenchymal differentiation. Thought to arise predominantly in deep soft tissue of extremities, these sarcomas have shown that they can affect a wide variety of organs and sites, however intraoral mucosal SS is rarely encountered and herein the authors present possibly the second reported case of a young lady presenting with a slow growing tumour arising in the gingivo-buccal sulcus that was reported as Synovial sarcoma on biopsy and subsequently confirmed using molecular studies, tumour demonstrating SS18-SSX2 fusion transcript...
January 8, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29325532/mesenteric-inflammatory-veno-occlusive-disease-occurring-during-the-course-of-ulcerative-colitis-a-case-report
#19
Yosuke Yamada, Ken Sugimoto, Yashiro Yoshizawa, Yoshifumi Arai, Yoshiro Otsuki, Tomio Arai, Yasuyuki Kobayashi, Yoshihiko Sato, Yoshisuke Hosoda
BACKGROUND: Mesenteric inflammatory veno-occlusive disease (MIVOD) is difficult to diagnose because of its rarity, nonspecific clinical findings, and frequent confusion with other diseases including inflammatory bowel disease. This report presents a very rare case of MIVOD that occurred during the course of ulcerative colitis (UC). CASE PRESENTATION: A 32-year-old man, who had been diagnosed with UC at the age of 29 and was in remission maintained by oral administration of 5-aminosalicylic acid (5-ASA), showed exacerbation of diarrhea and was admitted to the hospital...
January 11, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29324426/a-sweet-solution-the-use-of-medical-grade-honey-on-oral-mucositis-in-the-pediatric-oncology-patient
#20
Ferne T Elsass
INTRODUCTION: Pediatric patients develop mucositis when receiving treatments such as chemotherapy and radiation; the most common and sensitive is oral mucositis. Mouth rinses containing antimicrobial, antihistamine, and analgesic medications are the mainstay for pediatric patients; however, patients often refuse these rinses due to the taste or texture. Also, patients under 1 year of age are unable to use these products. OBJECTIVE: Herein, the improvement of oral mucositis with standard oral care and additional use of active Leptospermum honey in pediatric oncology patients after chemotherapy is demonstrated...
December 2017: Wounds: a Compendium of Clinical Research and Practice
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