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Cervical disc disease

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https://www.readbyqxmd.com/read/28739045/filamin-b-the-next-hotspot-in-skeletal-research
#1
REVIEW
Qiming Xu, Nan Wu, Lijia Cui, Zhihong Wu, Guixing Qiu
Filamin B (FLNB) is a large dimeric actin-binding protein which crosslinks actin cytoskeleton filaments into a dynamic structure. Up to present, pathogenic mutations in FLNB are solely found to cause skeletal deformities, indicating the important role of FLNB in skeletal development. FLNB-related disorders are classified as spondylocarpotarsal synostosis (SCT), Larsen syndrome (LS), atelosteogenesis (AO), boomerang dysplasia (BD), and isolated congenital talipes equinovarus, presenting with scoliosis, short-limbed dwarfism, clubfoot, joint dislocation and other unique skeletal abnormalities...
July 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28736356/finite-element-analysis-of-influence-of-axial-position-of-center-of-rotation-of-a-cervical-total-disc-replacement-on-biomechanical-parameters-simulated-two-level-replacement-based-on-a-validated-model
#2
Yang Li, Zhenjun Zhang, Zhenhua Liao, Zhongjun Mo, Weiqiang Liu
Finite element (FE) models have been widely used to predict biomechanical parameters of the cervical spine. Previous studies investigated the influence of position of rotational centers (RCs) of prostheses on the cervical biomechanical parameters after one-level total disc replacement (TDR). The purpose of this study was to make a further step by exploring the effects of axial position of RCs of prostheses on the cervical biomechanics after 2-level TDR. A validated FE model of C3-C7 segments and 2 prostheses, including the RC located at the superior endplate (SE) and inferior endplate (IE), was developed...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28718697/pain-drawings-predict-outcome-of-surgical-treatment-for-degenerative-disc-disease-in-the-cervical-spine
#3
Anna MacDowall, Yohan Robinson, Martin Skeppholm, Claes Olerud
INTRODUCTION: Pain drawings have been frequently used in the preoperative evaluation of spine patients. For lumbar conditions comprehensive research has established both the reliability and predictive value, but for the cervical spine most of this knowledge is lacking. The aims of this study were to validate pain drawings for the cervical spine, and to investigate the predictive value for treatment outcome of four different evaluation methods. METHODS: We carried out a post hoc analysis of a randomized controlled trial, comparing cervical disc replacement to fusion for radiculopathy related to degenerative disc disease...
July 18, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28713631/percutaneous-cervical-laser-diskectomy-thermoannuloplasty-and-thermonucleoplasty-comparable-results-without-surgery
#4
EDITORIAL
Nancy E Epstein
BACKGROUND: Utilizing the literature, the results of three different minimally invasive surgery (MIS) anterior cervical percutaneous operations for neck/mild radicular pain and magnetic resonance (MR)-documented "contained" (not extruded/sequestrated) discs were evaluated. Results were compared with patients treated nonsurgically for comparable/greater neurological compromise, and even more severe cervical disc disease. METHODS: There were three MIS percutaneous anterior cervical discectomy procedures...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28704907/effect-of-modic-changes-in-cervical-degenerative-disease
#5
Kyung Tag Kang, Dong Wuk Son, Oik Kwon, Su Hun Lee, Jong Uk Hwang, Dong Ha Kim, Jun Seok Lee, Geun Sung Song
OBJECTIVE: Modic changes are signal intensity changes in adjacent vertebral bone marrow on magnetic resonance imaging. Few studies have investigated these changes with regard to the cervical spine. In this study, we investigated the associations between cervical degenerative disease and Modic changes. METHODS: We conducted a retrospective collection of radiological data in patients with neck pain at Pusan National University Yangsan Hospital from January 2010 to December 2014...
June 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28700452/the-surgical-treatment-of-cervical-radiculopathy-meta-analysis-of-randomized-controlled-trials
#6
Gabriel Gutman, Derek H Rosenzweig, Jeff D Golan
STUDY DESIGN: Meta-analysis of published randomized controlled trials (RCTs). OBJECTIVE: To determine whether anterior cervical discectomy and fusion (ACDF), cervical disc replacement (CDR) or minimally invasive posterior cervical foraminotomy (MI-PCF) provides the best outcomes for patients with symptomatic single-level, single-side, cervical radiculopathy. SUMMARY OF BACKGROUND DATA: The surgical treatment of cervical radiculopathy is still controversial...
July 11, 2017: Spine
https://www.readbyqxmd.com/read/28673829/lumbar-spine-surgery-in-patients-with-rheumatoid-arthritis-ra-what-affects-the-outcomes
#7
Shoji Seki, Norikazu Hirano, Isao Matsushita, Yoshiharu Kawaguchi, Masato Nakano, Taketoshi Yasuda, Hiraku Motomura, Kayo Suzuki, Yasuhito Yahara, Kenta Watanabe, Hiroto Makino, Tomoatsu Kimura
BACKGROUND CONTEXT: While the cervical spine is only occasionally involved in rheumatoid arthritis (RA), involvement of the lumbar spine is even less common. A few reports on lumbar spinal stenosis in patients with RA have appeared. Although disc space narrowing occurs in aging, postoperative ASD in RA patients has not been subject to much analysis. PURPOSE: To investigate differences in adjacent segment disease (ASD) and clinical outcomes between lumbar spinal decompression with and without fusion in patients with rheumatoid arthritis (RA)...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28662992/candidate-gene-investigation-of-spinal-degenerative-osteoarthritis-in-greek-population
#8
E Liva, I Panagiotou, S Palikyras, E Parpa, E Tsilika, P Paschou, K Mystakidou
BACKGROUND CONTEXT: Few data exist concerning the natural history of degenerative osteoarthritis of the spine and its associated gene investigation. Degenerative osteoarthritis of the spine demonstrates an international prevalence of 15% in the general population and over 50% in people aged over 60 years. PURPOSE: The aim of this Greek case-control study is to examine gene polymorphisms that have been previously shown or hypothesized to be correlated to degenerative osteoarthritis of the spine...
June 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28660372/a-finite-element-study-of-traditional-chinese-cervical-manipulation
#9
Zhen Deng, Kuan Wang, Huihao Wang, Tianying Lan, Hongsheng Zhan, Wenxin Niu
PURPOSE: Traditional Chinese cervical manipulation (TCCM) has been claimed as an effective treatment for diseases of the cervical spine, but its biomechanical effects on the vertebral body and intervertebral discs remain unclear. The aim of this study was to develop and validate a detailed finite element model of cervical spine, which was then used to investigate the biomechanical response of the cervical spine to TCCM. METHODS: The model of a C2-T1 cervical spine was constructed based on CT images of a healthy male volunteer and validated against published in vitro studies under different loading conditions...
June 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28646343/clinical-outcome-following-anterior-cervical-discectomy-and-fusion-with-and-without-anterior-cervical-plating-for-the-treatment-of-cervical-disc-herniation-a-25-year-follow-up-study
#10
Benedikt W Burkhardt, Moritz Brielmaier, Karsten Schwerdtfeger, Joachim M Oertel
Extreme long-term clinical outcome studies following anterior cervical discectomy and fusion (ACDF) with an autologous iliac crest with and without Caspar plating (ACDF + CP) for the treatment of radiculopathy caused by cervical disc herniation (CDH) are extremely rare. Hospital records of patients who underwent ACDF or ACDF + CP for the treatment of CDH at least 17 years ago were reviewed. Information about diagnosis, surgery, pre- and postoperative clinical process, and repeated procedure was analyzed...
June 23, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28632590/comparison-of-anterior-and-posterior-surgery-for-degenerative-cervical-myelopathy-an-mri-based-propensity-score-matched-analysis-using-data-from-the-prospective-multicenter-aospine-csm-north-america-and-international-studies
#11
So Kato, Aria Nouri, Dongjin Wu, Satoshi Nori, Lindsay Tetreault, Michael G Fehlings
BACKGROUND: Surgeons often choose between 2 different approaches (anterior and posterior) for surgical treatment of degenerative cervical myelopathy on the basis of imaging features of spinal cord compression, the number of levels affected, and the spinal alignment. However, there is a lack of consensus on which approach is preferable. The objective of the present study was to use magnetic resonance imaging (MRI)-based propensity-score-matched analysis to compare postoperative outcomes between the anterior and posterior surgical approaches for degenerative cervical myelopathy...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28625479/the-change-of-adjacent-segment-after-cervical-disc-arthroplasty-compared-with-anterior-cervical-discectomy-and-fusion-a-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Liang Dong, Zhengwei Xu, Xiujin Chen, Dongqi Wang, Dichen Li, Tuanjing Liu, Dingjun Hao
BACKGROUD CONTEXT: Many meta-analyses have been performed to study the efficacy of cervical disc arthroplasty (CDA) compared with anterior cervical discectomy and fusion (ACDF); however, there are few data referring to adjacent segment within these meta-analyses, or investigators are unable to arrive at the same conclusion in the few meta-analyses about adjacent segment. With the increased concerns surrounding adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis) after anterior cervical surgery, it is necessary to perform a comprehensive meta-analysis to analyze adjacent segment parameters...
June 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#13
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28604460/intention-to-treat-analysis-of-radical-trachelectomy-for-early-stage-cervical-cancer-with-special-reference-to-oncologic-failures-single-institutional-experience-in-hungary
#14
Robert Póka, Szabolcs Molnár, Péter Daragó, János Lukács, Rudolf Lampé, Zoárd Krasznai, Zoltán Hernádi
OBJECTIVE: The aim of our study was to evaluate clinical and pathological data in order to draw eligibility criteria for oncologically sufficient radical trachelectomy (RT) in early-stage cervical cancer. Reviewing all cases of attempted RT performed at our unit, we focused attention on prognostic indicators of the need for additional oncologic treatment following RT. The analysis was extended by extensive literature review to include previously published cases of oncologic failures. METHODS: The authors retrospectively analyzed data of patients who underwent RT at the Department of Obstetrics and Gynecology, University of Debrecen...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28582418/an-in-vivo-comparison-study-in-goats-for-a-novel-motion-preserving-cervical-joint-system
#15
Jie Qin, Chenguang Zhao, Dong Wang, Bo Zhao, Jun Dong, Haopeng Li, Rongxia Sang, Shuang Wang, Jiao Fu, Rangrang Kong, Xijing He
Cervical degenerative disease is one of the most common spinal disorders worldwide, especially in older people. Anterior cervical corpectomy and fusion (ACCF) is a useful method for the surgical treatment of multi-level cervical degenerative disease. Anterior cervical disc replacement (ACDR) is considered as an alternative surgical method. However, both methods have drawbacks, particularly the neck motion decrease observed after arthrodesis, and arthroplasty should only be performed on patients presenting with cervical disc disease but without any vertebral body disease...
2017: PloS One
https://www.readbyqxmd.com/read/28575461/adjacent-segment-degeneration-after-anterior-cervical-discectomy-and-fusion-with-an-autologous-iliac-crest-graft-a-magnetic-resonance-imaging-study-of-59-patients-with-a-mean-follow-up-of-27%C3%A2-yr
#16
Benedikt W Burkhardt, Andreas Simgen, Gudrun Wagenpfeil, Wolfgang Reith, Joachim M Oertel
BACKGROUND: Anterior cervical decompression and fusion (ACDF) is a widely accepted surgical technique for the treatment of degenerative disc disease. ACDF is associated with adjacent segment degeneration (ASD). OBJECTIVE: To assess whether physiological aging of the spine would overcome ASD by comparing adjacent to adjoining segments more than 18 yr after ACDF. METHODS: Magnetic resonance imaging of 59 (36 male, 23 female) patients who underwent ACDF was performed to assess degeneration...
May 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28574978/adjacent-segment-degeneration-following-anterior-cervical-discectomy-and-fusion-versus-the-bryan-cervical-disc-arthroplasty
#17
Suo-Zhou Yan, Jun Di, Yong Shen
BACKGROUND Anterior cervical discectomy and fusion (ACDF) is an established treatment for degenerative disease of the cervical disc, but adjacent segment degeneration or instability may develop long term. The aim of this study was to investigate the risk factors for adjacent segment degeneration following ACDF compared with the use of the Bryan artificial disc for cervical disc arthroplasty (CDA). MATERIAL AND METHODS A prospective comparative study included 93 patients who underwent ACDF or CDA with the Bryan artificial cervical disc between 2002 and 2004, and who had more than eight years of follow-up...
June 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28560466/real-life-effectiveness-of-spa-therapy-in-rheumatic-and-musculoskeletal-diseases-a-retrospective-study-of-819-patients
#18
Mine Karagülle, Sinan Kardeş, Müfit Zeki Karagülle
The objective of this study is to determine the use and efficacy of spa therapy in patients with a wide spectrum of rheumatic and musculoskeletal diseases under real-life clinical practice circumstances. In this retrospective observational study at the Medical Ecology and Hydroclimatology Department of Istanbul Faculty of Medicine, the records of all adult patients with rheumatic and musculoskeletal diseases who were prescribed a spa therapy in various health resorts in Turkey between 2002 and 2012 were analyzed...
May 30, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28559077/incidence-and-risk-factors-of-postoperative-adjacent-segment-degeneration-following-anterior-decompression-and-instrumented-fusion-for-degenerative-disorders-of-the-cervical-spine
#19
Hui Wang, Lei Ma, Dalong Yang, Sidong Yang, Wenyuan Ding
INTRODUCTION: The aim of this study was to explore the incidence and risk factors of postoperative adjacent segment degeneration following anterior decompression and instrumented fusion for degenerative disorders of the cervical spine, and hope to provide references in decision making and surgical planning for spinal surgeons. METHODS: By retrieving the medical records from January 2005 to September 2011, 283 patients were retrospectively reviewed. According to the occurrence of adjacent segment degeneration at follow up, patients were divided into two groups: ASD group and no ASD group...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28536978/a-6-dof-parallel-bone-grinding-robot-for-cervical-disc-replacement-surgery
#20
Heqiang Tian, Chenchen Wang, Xiaoqing Dang, Lining Sun
Artificial cervical disc replacement surgery has become an effective and main treatment method for cervical disease, which has become a more common and serious problem for people with sedentary work. To improve cervical disc replacement surgery significantly, a 6-DOF parallel bone-grinding robot is developed for cervical bone-grinding by image navigation and surgical plan. The bone-grinding robot including mechanical design and low level control is designed. The bone-grinding robot navigation is realized by optical positioning with spatial registration coordinate system defined...
May 24, 2017: Medical & Biological Engineering & Computing
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