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cerebral vasospasm

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https://www.readbyqxmd.com/read/28339483/temporal-evolution-of-vasospasm-and-clinical-outcome-after-intra-arterial-vasodilator-therapy-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#1
Laleh Daftari Besheli, Can Ozan Tan, Donnie L Bell, Joshua A Hirsch, Rajiv Gupta
Intra-arterial (IA) vasodilator therapy is one of the recommended treatments to minimize the impact of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm refractory to standard management. However, its usefulness and efficacy is not well established. We evaluated the effect IA vasodilator therapy on middle cerebral artery blood flow and on discharge outcome. We reviewed records for 115 adults admitted to Neurointensive Care Unit to test whether there was a difference in clinical outcome (discharge mRS) in those who received IA infusions...
2017: PloS One
https://www.readbyqxmd.com/read/28335661/safety-and-efficacy-of-balloon-angioplasty-of-the-anterior-cerebral-artery-for-vasospasm-treatment-after-subarachnoid-hemorrhage
#2
Nauman S Chaudhry, Jennifer L Orning, Sophia F Shakur, Sepideh Amin-Hanjani, Victor A Aletich, Fady T Charbel, Ali Alaraj
Balloon angioplasty is often performed for symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. Angioplasty of the anterior cerebral artery (ACA), however, is perceived to be a challenging endeavor and not routinely performed due to technical and safety concerns. Here, we evaluate the safety and efficacy of balloon angioplasty of the anterior cerebral artery for vasospasm treatment. Patients with vasospasm following subarachnoid hemorrhage who underwent balloon angioplasty at our institution between 2011 and 2016 were retrospectively reviewed...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28335640/nebivolol-attenuates-cerebral-vasospasm-both-by-increasing-endothelial-nitric-oxide-and-by-decreasing-oxidative-stress-in-an-experimental-subarachnoid-haemorrhage
#3
Mehmet Arif Aladag, Yusuf Turkoz, Hakan Parlakpinar, Mehmet Gul
OBJECTIVE: Evidence suggests that reduction of nitric oxide (NO) bioavailability due to oxidative stress plays a central role in the pathophysiology of cerebral vasospasm after subarachnoid haemorrhage (SAH). To prevent SAH-induced cerebral vasospasm, therefore we used nebivolol hydrochloride as a NO-mediated vasodilator and an antioxidant drug in an experimental rat model of SAH. MATERIALS AND METHODS: Forty female Wistar rats were divided into control, SAH, SAH plus placebo, and SAH plus nebivolol groups...
March 23, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28323187/activation-of-cytotoxic-natural-killer-cells-after-aneurysmal-subarachnoid-haemorrhage
#4
Daniel Spitzer, Nina Johanna Spitzer, Monika Deininger, Christian Rainer Wirtz, Ralph König, Timo Burster, Thomas Kapapa
OBJECTIVE: Cell-mediated inflammation is critical in development of cerebrovascular complications after aneurysmal subarachnoid haemorrhage (aSAH). We analysed the course for activated CD16(bright)CD56(dim) cytotoxic NKCSF cells (NK) in cerebrospinal fluid (CSF) of 15 patients. METHODS: Patients were classified by occurrence of cerebral vasospasm and delayed cerebral ischemia. NK were monitored by flow cytometry between day 1 and 14 after haemorrhage. RESULTS: 12 (80%) patients developed CV with a mean day of detection at 3...
March 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28323180/early-and-severe-symptomatic-cerebral-vasospasm-after-mild-traumatic-brain-injury-case-report
#5
Kyle Ogami, Melissa Dofredo, Asma M Moheet, Shouri Lahiri
BACKGROUND: Symptomatic cerebral vasospasm has been reported in a low percentage of patients with moderate or severe traumatic brain injury as defined by Glasgow Coma Score (GCS). Here, we present case of mild traumatic brain injury (GCS 14) complicated by early and severe symptomatic cerebral vasospasm. CASE DESCRIPTION: A 63-year-old female was admitted following mild traumatic brain injury with a Glasgow Coma Score of 14. Concurrent with the onset of sonographic vasospasm, the patient developed severe neurological symptoms consistent with ischemia of the left middle cerebral artery territory...
March 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28320115/reversible-cerebral-vasoconstriction-syndrome-in-puerperium-a-prospective-study
#6
Gian Paolo Anzola, Renato Brighenti, Milena Cobelli, Alessia Giossi, Sara Mazzucco, Silvia Olivato, Elisa Pari, Maria Paola Piras, Alessandro Padovani, Fabrizio Rinaldi, Giulia Turri
BACKGROUND AND AIM OF THE STUDY: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by severe "thunderclap" headache, with or without associated neurological symptoms and neuroimaging findings of reversible vasoconstriction of cerebral arteries. Puerperium is a recognized precipitant, but the incidence of puerperal RCVS is unknown. We conducted a prospective study to assess incidence, risk factors and clinical features of RCVS. MATERIAL AND METHOD: Nine-hundred consecutive puerperae were prospectively enrolled within three days of delivery...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28302352/neuroinflammation-responses-after-subarachnoid-hemorrhage-a-review
#7
REVIEW
Vera Zhiyuan Zheng, George Kwok Chu Wong
Subarachnoid hemorrhage (SAH) is an important cause of stroke mortality and morbidity, especially in the young stroke population. Recent evidences indicate that neuroinflammation plays a critical role in both early brain injury and the delayed brain deterioration after SAH, including cellular and molecular components. Cerebral vasospasm (CV) can lead to death after SAH and independently correlated with poor outcome. Neuroinflammation is evidenced to contribute to the etiology of vasospasm. Besides, systemic inflammatory response syndrome (SIRS) commonly occurs in the SAH patients, with the presence of non-infectious fever and systematic complications...
March 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28295256/visualization-of-stimulus-specific-heterogeneous-activation-of-individual-vascular-smooth-muscle-cells-in-aortic-tissues
#8
Satoshi Komatsu, Toshio Kitazawa, Mitsuo Ikebe
Intercellular communication among autonomic nerves, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) plays a central role in an uninterrupted regulation of blood flow through vascular contractile machinery. Impairment of this communication is linked to development of vascular diseases such as hypertension, cerebral/coronary vasospasms, aortic aneurism, and erectile dysfunction. Although the basic concept of the communication as a whole has been studied, the spatiotemporal correlation of ECs/VSMCs in tissues at the cellular level is unknown...
March 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28284449/cerebral-vasospasm-after-transsphenoidal-surgery-for-pituitary-adenoma-case-report-and-review-of-the-literature
#9
N Bougaci, P Paquis
INTRODUCTION: Cerebral vasospasm (CVS) is a rare complication of transsphenoidal surgery for pituitary adenomas. CASE REPORT: The authors describe a symptomatic cerebral ischemia due to an internal carotid, left middle cerebral artery and anterior cerebral artery vasospasm in a patient undergoing transsphenoidal surgery for a pituitary macro adenoma. The patient was successfully treated by an endovascular balloon angioplasty. CONCLUSION: This issue should be taken into account, even when rare, in every patient who has surgery for a pituitary tumor, particularly when it concerns a large macro adenoma with suprasellar extension...
March 8, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28277457/advanced-mri-measures-of-cerebral-perfusion-and-their-clinical-applications
#10
Bryan Lanzman, Jeremy J Heit
Cerebral blood flow measurement by magnetic resonance imaging perfusion (MRP) techniques is broadly applied to patients with acute ischemic stroke, vasospasm following aneurysmal subarachnoid hemorrhage, chronic arterial steno-occlusive disease, cervical atherosclerotic disease, and primary brain neoplasms. MRP may be performed using an exogenous tracer, most commonly gadolinium-based intravenous contrast, or an endogenous tracer, such as arterial spin labeling (ASL) or intravoxel incoherent motion (IVIM). Here, we review the technical basis of commonly performed MRP techniques, the interpretation of MRP imaging maps, and how MRP provides valuable clinical information in the triage of patients with cerebral disease...
March 8, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28267024/effectiveness-of-intrathecal-nicardipine-on-cerebral-vasospasm-in-non-traumatic-subarachnoid-hemorrhage-a-systematic-review-protocol
#11
Daniel Stuart, Robin Christian, Hartmut Uschmann
The objective of this review is to determine the effectiveness of intrathecal (IT) nicardipine on cerebral vasospasm and its impact on the following outcome measures: mean flow velocities, angiographic and/or clinical vasospasm and infection rates. Specifically, the review question is: What is the effectiveness of IT nicardipine on cerebral vasospasm in adult patients with aneurysmal subarachnoid hemorrhage?
March 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28261769/evaluation-of-risk-factors-and-development-of-acute-kidney-injury-in-aneurysmal-subarachnoid-hemorrhage-head-injury-and-severe-sepsis-septic-shock-patients-during-icu-treatment
#12
Ceren Kamar, Achmet Ali, Demet Altun, Günseli Orhun, Akın Sabancı, Altay Sencer, İbrahim Özkan Akıncı
BACKGROUND: There are few studies examining development of acute kidney injury (AKI) in the various types of patients in intensive care units (ICUs). Presently described is evaluation of risk factors and development of AKI in different groups of ICU patients. METHODS: Present study was performed in 3 different ICUs. Development of AKI was measured using Acute Kidney Injury Network (AKIN) classification system. Total of 300 patients who were treated in trauma, neurosurgery, or general ICU departments (due to head injury, aneurysmal subarachnoid hemorrhage [aSAH], or severe sepsis/septic shock, respectively) were assessed for incidence, risk factors, and development of AKI...
January 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28257639/management-and-long-term-evolution-of-a-patient-with-3-hydroxy-3-methylglutaryl-coenzyme-a-lyase-deficiency
#13
Juan Ignacio Muñoz-Bonet, María Del Carmen Ortega-Sánchez, José Luis León Guijarro
BACKGROUND: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase deficiency is a rare inborn error of metabolism characterized by recurrent metabolic crises caused by fasting, intercurrent illness and excessive physical exercise. Non ketotic hypoglycemia is normally the cause of primary symptoms but without an immediate treatment the illness can evolve into a worsening metabolic state resembling the Reye's syndrome that may cause the patient's death. We report a case with some clinical and therapeutic features not previously described...
January 19, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28244007/effects-of-tenascin-c-knockout-on-cerebral-vasospasm-after-experimental-subarachnoid-hemorrhage-in-mice
#14
Masashi Fujimoto, Masato Shiba, Fumihiro Kawakita, Lei Liu, Naoshi Shimojo, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Hidenori Suzuki
A matricellular protein tenascin-C (TNC) has been suggested to play a role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH), but the direct evidence remains lacking. In this study, we examined effects of TNC knockout (TNKO) on cerebral vasospasm after experimental SAH in mice. C57BL/6 wild-type (WT) or TNKO mice were subjected to SAH by endovascular puncture. Ten WT and ten TNKO mice were randomized to WT sham (n = 4), TNKO sham (n = 4), WT SAH (n = 6), and TNKO SAH (n = 6) groups...
February 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28241122/numerical-investigation-of-vasospasm-detection-by-extracranial-blood-velocity-ratios
#15
Jaiyoung Ryu, Nerissa Ko, Xiao Hu, Shawn C Shadden
BACKGROUND: Early diagnosis of vasospasm following subarachnoid hemorrhage can prevent cerebral ischemia and improve neurological outcomes. This study numerically evaluates the relevance of extracranial blood velocity indices to detect vasospasm. METHODS: A numerical model of cerebral blood flow was used to evaluate the hemodynamics associated with anterior and posterior vasospasm under normal and impaired cerebral autoregulation conditions. Extracranial blood velocities at the carotid and vertebral arteries and their ratios between ipsilateral and contralateral, anterior and posterior, and downstream and upstream arteries were monitored during vasospasm progression...
February 28, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28236869/intraventricular-hemorrhage-after-dural-fistula-embolization
#16
Joana Chaves Gonçalves Rodrigues de Carvalho, Francisco Javier Tercero Machin, Luis San Roman Manzanera, Jordi Blasco Andaluz, Sílvia Herrero Nogués, Núria Peix Soriano, Victor Obach Baurier, Enrique Jesus Carrero Cardenal
BACKGROUND AND OBJECTIVES: Dural arteriovenous fistulas are anomalous shunts between dural arterial and venous channels whose nidus is located between the dural leaflets. For those circumstances when invasive treatment is mandatory, endovascular techniques have grown to become the mainstay of practice, choice attributable to their reported safety and effectiveness. We describe the unique and rare case of a dural arteriovenous fistula treated by transarterial embolization and complicated by an intraventricular hemorrhage...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28236213/ethyl-pyruvate-attenuates-early-brain-injury-following-subarachnoid-hemorrhage-in-the-endovascular-perforation-rabbit-model-possibly-via-anti-inflammation-and-inhibition-of-jnk-signaling-pathway
#17
Tao Lv, Yi-Feng Miao, Yi-Chao Jin, Shao-Feng Yang, Hui Wu, Jiong Dai, Xiao-Hua Zhang
Early brain injury (EBI) following subarachnoid hemorrhage (SAH) is the main cause to poor outcomes of SAH patients, and early inflammation plays an important role in the acute pathophysiological events. It has been demonstrated that ethyl pyruvate (EP) has anti-inflammatory and neuroprotective effects in various critical diseases, however, the role of EP on EBI following SAH remains to be elucidated. Our study aimed to evaluate the effects of EP on EBI following SAH in the endovascular perforation rabbit model...
February 25, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28225470/life-threatening-tachyarrhythmia-following-intra-arterial-milrinone-for-cerebral-vasospasm
#18
Smita Vimala, Soumya Madhusudhan, Bimal K Sahoo
No abstract text is available yet for this article.
February 20, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28217390/management-of-aneurysmal-subarachnoid-hemorrhage-state-of-the-art-and-future-perspectives
#19
REVIEW
Giovanni Grasso, Concetta Alafaci, R Loch Macdonald
BACKGROUND: Aneurysmal subarachnoid hemorrhage (SAH) accounts for 5% of strokes and carries a poor prognosis. It affects around 6 cases per 100,000 patient years occurring at a relatively young age. METHODS: Common risk factors are the same as for stroke, and only in a minority of the cases, genetic factors can be found. The overall mortality ranges from 32% to 67%, with 10-20% of patients with long-term dependence due to brain damage. An explosive headache is the most common reported symptom, although a wide spectrum of clinical disturbances can be the presenting symptoms...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28215029/an-introduction-to-the-pathophysiology-of-aneurysmal-subarachnoid-hemorrhage
#20
REVIEW
Jasper H van Lieshout, Maxine Dibué-Adjei, Jan F Cornelius, Philipp J Slotty, Toni Schneider, Tanja Restin, Hieronymus D Boogaarts, Hans-Jakob Steiger, Athanasios K Petridis, Marcel A Kamp
Pathophysiological processes following subarachnoid hemorrhage (SAH) present survivors of the initial bleeding with a high risk of morbidity and mortality during the course of the disease. As angiographic vasospasm is strongly associated with delayed cerebral ischemia (DCI) and clinical outcome, clinical trials in the last few decades focused on prevention of these angiographic spasms. Despite all efforts, no new pharmacological agents have shown to improve patient outcome. As such, it has become clear that our understanding of the pathophysiology of SAH is incomplete and we need to reevaluate our concepts on the complex pathophysiological process following SAH...
February 18, 2017: Neurosurgical Review
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