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cerebral vasospasm

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https://www.readbyqxmd.com/read/28503488/treatment-of-cerebral-vasospasm-in-an-infant-using-a-modified-dotter-technique
#1
Brian M Snelling, Samir Sur, Sumedh S Shah, Eric C Peterson
An 8-month old female presented with spontaneous subarachnoid hemorrhage and was treated successfully with endovascular coil embolization of the ruptured aneurysm. Transcranial Doppler ultrasound performed four days later demonstrated middle cerebral artery (MCA) velocities greater than 350 cm/sec on the right and greater than 200 cm/sec on the left, despite medical management. The patient demonstrated no focal neurological deficits, though examination was limited by our patient's sedation and intubation. Angiography revealed severe vasospasm of the supraclinoid internal carotid and MCA territories, bilaterally...
March 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/28499220/effects-of-preadmission-beta-blockers-on-neurogenic-stunned-myocardium-after-aneurysmal-subarachnoid-hemorrhage-a-meta-analysis
#2
Hai Luo, Wei-Xin Song, Jin-Wen Jiang, Jian-Lan Zhao, Wei-Lin Rong, Mei-Hua Li
OBJECTIVE: Spontaneous subarachnoid hemorrhage is mostly caused by the rupture of an aneurysm. Neurogenic stunned myocardium (NSM) is one of the most frequent complications caused by aneurysmal subarachnoid hemorrhage (aSAH). The possible pathogenesis of NSM may be that the catecholamine peak resulting from aSAH leads to subendocardial ischemia or coronary artery spasm. We designed this meta-analysis to find out whether beta-blockers (BB) can significantly reduce the incidence of NSM and improve the outcomes of aSAH...
May 1, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28484291/follow-up-of-vasospasm-by-transcranial-doppler-sonography-tcd-in-subarachnoid-hemorrhage-sah
#3
Jasminka Djelilovic-Vranic, Vanja Basic-Kes, Merita Tiric-Campara, Edina Djozic, Jasmin Kulenovic
INTRODUCTION: Subarachnoid hemorrhage (SAH)represents hemorrhage in the space between arachnoidea and pia mater, due to aneurysm burst, spontaneously or as a consequence of trauma. It is condition that occurs more common in women than men, and its most common complications are rebleeding and vazospasm. As a result of vasospasm, develops ischemia in the portion of brain tissue that can cause additional neurological deficit. Transcranial Doppler Sonography (TCD) is a noninvasive ultrasound diagnostic method that allows monitoring of the state of intracerebral hemodynamics...
March 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28481394/the-effect-of-intravenous-l-carnitine-on-vasospasm-process-in-the-experimental-subarachnoid-hemorrhage-model
#4
Ahmet Soyer, Murat Gokten, Kamil Oge, Figen Soylemezoglu
AIM: Cerebral vasospasm after subarachnoid hemorrhage (SAH) is an important cause of morbidity and mortality. In this study we examined the effects of L-carnitine on cerebral vasospasm process. MATERIAL AND METHODS: Twenty male New Zealand white rabbits were randomly divided into 4 groups. Group 1 served as control; group 2 were not subjected to SAH and received intravenous L-carnitine 3 times; group 3 were subjected to SAH and group 4 were subjected to SAH and treated with 100 mg/kg intravenous L-carnitine at 0 24 and 48 hours after SAH...
March 25, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28468328/heparin-and-heparin-derivatives-in-post-subarachnoid-hemorrhage-brain-injury-a-multimodal-therapy-for-a-multimodal-disease
#5
REVIEW
Erik G Hayman, Akil P Patel, Robert F James, J Marc Simard
Pharmacologic efforts to improve outcomes following aneurysmal subarachnoid hemorrhage (aSAH) remain disappointing, likely owing to the complex nature of post-hemorrhage brain injury. Previous work suggests that heparin, due to the multimodal nature of its actions, reduces the incidence of clinical vasospasm and delayed cerebral ischemia that accompany the disease. This narrative review examines how heparin may mitigate the non-vasospastic pathological aspects of aSAH, particularly those related to neuroinflammation...
May 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28463833/preventive-effect-of-clazosentan-against-cerebral-vasospasm-after-clipping-surgery-for-aneurysmal-subarachnoid-hemorrhage-in-japanese-and-korean-patients
#6
Miki Fujimura, Jin-Yang Joo, Jong-Soo Kim, Motonori Hatta, Yoshinari Yokoyama, Teiji Tominaga
BACKGROUND: Clazosentan has been explored worldwide for the prophylaxis of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). In a dose-finding trial (CONSCIOUS-1) conducted in Israel, Europe, and North America, clazosentan (1, 5, and 15 mg/h) significantly reduced the incidence of cerebral vasospasm, but its efficacy in Japanese and Korean patients was unknown. We conducted a double-blind comparative study to evaluate the occurrence of cerebral vasospasm in Japanese and Korean patients with aSAH...
May 3, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28461780/assessment-of-pre-and-post-operative-cerebral-perfusion-in-anterior-circulation-intracranial-aneurysm-clipping-patients-at-hospital-sungai-buloh-using-ct-perfusion-scan-and-correlations-to-fisher-navarro-and-wfns-scores
#7
Ailani Ab Ghani, Saiful Azli Mat Nayan, Regunath Kandasamy, Abdul Rahman Izani Ghani, Azmin Kass Rosman
BACKGROUND: Intracranial aneurysms may rupture and are typically associated with high morbidity and mortality, commonly due to vasospasm after rupture. Once the aneurysm ruptures, the patient's cerebral blood flow may be disturbed during the acute phase, affecting cerebral circulation and thus cerebral perfusion prior to the onset of vasospasm. Fisher and Navarro scores are used to predict vasospasm, while World Federation of Neurosurgical Societies (WFNS) scores are used to predict patient outcomes...
February 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28455691/long-lasting-cerebral-vasospasm-microthrombosis-apoptosis-and-paravascular-alterations-associated-with-neurological-deficits-in-a-mouse-model-of-subarachnoid-hemorrhage
#8
Mohamad El Amki, Martine Dubois, Antoine Lefevre-Scelles, Nicolas Magne, Mélanie Roussel, Thomas Clavier, Pierre-Olivier Guichet, Emmanuel Gérardin, Vincent Compère, Hélène Castel
Subarachnoid hemorrhage (SAH) is a devastating disease with high mortality and morbidity. Long-term cognitive and sensorimotor deficits are serious complications following SAH but still not well explained and described in mouse preclinical models. The aim of our study is to characterize a well-mastered SAH murine model and to establish developing pathological mechanisms leading to cognitive and motor deficits, allowing identification of specific targets involved in these long-term troubles. We hereby demonstrate that the double blood injection model of SAH induced long-lasting large cerebral artery vasospasm (CVS), microthrombosis formation and cerebral brain damage including defect in potential paravascular diffusion...
April 28, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28431602/a-comprehensive-analysis-of-the-relationship-between-aca-velocities-and-aca-infarction-following-aneurysmal-subarachnoid-hemorrhage
#9
Michael Moussouttas, Jocelyn Cheng, Joseph Antonakakis, Ameesh Patel, Maria Iuanow
PURPOSE: To evaluate the relationship between anterior cerebral artery (ACA) velocities (and ancillary parameters) and ACA infarction following aneurysmal subarachnoid hemorrhage (aSAH), and to examine the factors that influence velocities. METHODS: Retrospective investigation of 500 consecutive aSAH patients. ACA mean velocities (Vm) were evaluated by daily transcranial ultrasound during the early (days 1-4) and late (days 5-20) periods posthemorrhage. Presence and timing of acute ACA infarctions were identified by serial retrospective review of cerebral computerized tomography (CT) scans...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28427768/syndrome-of-transient-headache-and-neurological-deficits-with-cerebrospinal-fluid-lymphocytosis-handl-in-a-patient-with-confusional-symptoms-diffuse-eeg-abnormalities-and-bilateral-vasospasm-in-transcranial-doppler-ultrasound-a-case-report-and-literature-review
#10
M Hidalgo de la Cruz, R Domínguez Rubio, E Luque Buzo, F Díaz Otero, P Vázquez Alén, J Orcajo Rincón, J Prieto Montalvo, A Contreras Chicote, F Grandas Pérez
INTRODUCTION: HaNDL syndrome (transient headache and neurological deficits with cerebrospinal fluid lymphocytosis) is characterised by one or more episodes of headache and transient neurological deficits associated with cerebrospinal fluid lymphocytosis. To date, few cases of HaNDL manifesting with confusional symptoms have been described. Likewise, very few patients with HaNDL and confusional symptoms have been evaluated with transcranial Doppler ultrasound (TCD). TCD data from patients with focal involvement reveal changes consistent with vasomotor alterations...
April 17, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28416786/basilar-artery-vasospasm-after-pretuncal-non-aneurysmal-subarachnoid-hemorrhage-responding-to-milrinone
#11
Abdulrahman Y Alturki, Abdullah S Alamri, Mohamed M Badawy, Benjamin W Lo
Pretruncal (perimesencephalic) non-aneurysmal subarachnoid hemorrhage (PNSAH) is uniformly associated with an excellent outcome. Although cerebral vasospasm remains a common complication of SAH and constitutes an important predictor of outcome, in the setting of PNSAH, it is extremely rare. Preturnal non-aneurysmal subarac refers to a subset of SAH patients with a characteristic pattern of localized blood on CT of the head, normal cerebral angiography, and benign course when compared to the aneurysmal SAH population...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28415958/glycyrrhizic-acid-exerts-anti-inflammatory-effect-to-improve-cerebral-vasospasm-secondary-to-subarachnoid-hemorrhage-in-a-rat-model
#12
Yi Li, Fengbin Sun, Zhaohui Jing, Xuhui Wang, Xuming Hua, Liang Wan
This study aimed to investigate the therapeutic effect of glycyrrhizic acid (GA) on the cerebral vasospasm (CVS) in a rat subarachnoid hemorrhage (SAH) model and to explore the potential mechanism. A total of 44 healthy male rats were randomly assigned into 3 groups: control group (n = 12), SAH group (n = 16) and GA group (n = 16). No treatment was conducted in control group; in SAH group and GA group, experimental CVS was induced using a double-hemorrhage model and then rats were intraperitoneally injected with normal saline and GA at 10 mg/kg, respectively, once daily...
April 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28400792/toll-like-receptor-4-as-a-possible-therapeutic-target-for-delayed-brain-injuries-after-aneurysmal-subarachnoid-hemorrhage
#13
REVIEW
Takeshi Okada, Hidenori Suzuki
Neuroinflammation is a well-recognized consequence of subarachnoid hemorrhage (SAH), and Toll-like receptor (TLR) 4 may be an important therapeutic target for post-SAH neuroinflammation. Of the TLR family members, TLR4 is expressed in various cell types in the central nervous system, and is unique in that it can signal through both the myeloid differentiation primary-response protein 88-dependent and the toll receptor associated activator of interferon-dependent cascades to coordinate the maximal inflammatory response...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28386837/effect-of-delayed-onset-prostacyclin-on-markers-of-endothelial-function-and-damage-after-subarachnoid-hemorrhage
#14
Mikkel Gybel-Brask, Rune Rasmussen, Jakob Stensballe, Pär I Johansson, Sisse R Ostrowski
BACKGROUND: Subarachnoid hemorrhage (SAH) is a neurological emergency. Delayed ischemic neurological deficit is one of the main causes of poor outcome after SAH and is probably caused, at least in part, by cerebral vasospasm. The pathophysiology of this is multifaceted, but endothelial damage and activation as well as glycocalyx damage have been implicated. Prostacyclin has been shown to protect damaged and activated endothelium and to facilitate glycocalyx repair. We investigated biomarkers of endothelial activation and damage in patients with SAH randomized to 5 days prostacyclin infusion or placebo...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28383092/effects-of-arginine-vasopressin-and-v1-receptor-antagonist-on-cerebral-vasospasm-secondary-to-subarachnoid-hemorrhage-an-experimental-study
#15
Derviş Mansuri Yilmaz, Ersin Haciyakupoğlu, Serkan Diril, Leman Sencar, Erol Akgül, Sait Polat, Sebahattin Haciyakupoğlu, Ersin Nazlican
AIM: The aim of this study is to examine morphological, radiological and biochemical effects of arginine vasopressin(AV) and AV V1 receptor antagonist cerebral vasospasm(CVS) in rabbit subarachnoid hemorrhage(SAH). MATERIAL AND METHODS: Forty male New Zealand white rabbits were randomly divided to four groups comprising 10 rabbits each. The groups were 1) control, 2) subarachnoid hemorrhage(SAH), 3) SAH+AV application, 4) SAH+V1 antagonist of AV V1 receptor Diameters of the basilar artery of all the groups were measured on angiograms...
March 9, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28379540/hyperglycemia-aggravates-cerebral-vasospasm-after-subarachnoid-hemorrhage-in-a-rat-model
#16
Yu-Hua Huang, Chia-Li Chung, Hung-Pei Tsai, Shu-Chuan Wu, Chih-Zen Chang, Chee-Yin Chai, Tao-Chen Lee, Aij-Lie Kwan
BACKGROUND: Hyperglycemia is common and showed to be risky for poor prognosis in patients with subarachnoid hemorrhage (SAH). However, the causality and mechanism underlying this observation are not well established. OBJECTIVE: To investigate the relationship between hyperglycemia and cerebral vasospasm with its pathogenesis in a rat model of SAH. METHODS: One-shot SAH model was employed in male Sprague-Dawley rats. Hyperglycemia was triggered by intraperitoneal streptozotocin administration (50 mg/kg) 7 days before SAH induction...
March 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28373616/oculomotor-nerve-palsy-in-a-patient-with-a-ruptured-middle-cerebral-artery-aneurysm
#17
Suguru Yokosako, Yuichiro Kikkawa, Ririko Takeda, Toshiki Ikeda, Hiroki Kurita
We describe a case of acute oculomotor nerve palsy caused by a ruptured middle cerebral artery (MCA) aneurysm. A 59-year-old female presenting with headache and nausea was admitted to our hospital. Her consciousness was alert, and had no other neurological deficit without left oculomotor nerve palsy. A computed tomography (CT) showed SAH extending from left sylvian cistern to basal cistern. CT angiography revealed a left MCA aneurysm which protruded toward internal carotid artery. The patient was successfully treated with surgical clipping...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28365434/ultra-early-angiographic-vasospasm-after-aneurysmal-subarachnoid-hemorrhage-a%C3%A2-systematic-review-and-meta-analysis
#18
REVIEW
Kevin Phan, Justin M Moore, Christoph J Griessenauer, Joshua Xu, Ian Teng, Adam A Dmytriw, Albert H Chiu, Christopher S Ogilvy, Ajith Thomas
OBJECTIVE: After aneurysmal subarachnoid hemorrhage (aSAH), prognosis is affected heavily by the presence of delayed cerebral ischemia (DCI). There is growing recognition of ultra-early angiographic vasospasm (UEAV) occurring within 48 hours of aSAH; however, its relationship with DCI and ultimately prognosis remains unclear. METHODS: Various databases limited to the English language through September 2016 were searched systematically. Eligible studies were those comparing UEAV with control non-UEAV outcomes and follow-up...
March 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28352965/dual-energy-ct-to-diagnose-pseudoedema-in-contrast-induced-encephalopathy-following-cerebral-angiography
#19
Gabriel L Pagani-Estévez, Deena M Nasr, Waleed Brinjikji, Avital Perry, Jennifer E Fugate
BACKGROUND: Contrast-induced encephalopathy (CIE) is a syndrome that may be clinically unrecognized and misdiagnosed as cerebral edema. METHODS: Case report and review. RESULTS: A 72-year-old woman was admitted for elective endovascular embolization of a 10-mm left anterior communicating artery aneurysm. One hour post-procedure, she acutely developed global aphasia. Emergent head computed tomography (CT) and computed tomography-angiography (CTA) showed high attenuation of the left hemispheric subarachnoid spaces interpreted as hemispheric edema; emergent magnetic resonance imaging revealed left hemispheric punctate infarcts...
March 28, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28344178/systemic-and-cerebral-concentration-of-nimodipine-during-established-and-experimental-vasospasm-treatment
#20
Walid Albanna, Miriam Weiss, Catharina Conzen, Hans Clusmann, Toni Schneider, Martin Reinsch, Marguerite Müller, Martin Wiesmann, Anke Höllig, Gerrit Alexander Schubert
BACKGROUND: Oral nimodipine is an established prophylactic agent for cerebral vasospasm after subarachnoid hemorrhage (SAH). In highly selected cases, intraarterial or intravenous application of nimodipine may be considered; optimum dosage and modality of application, however, remain a matter of debate. Analysis of nimodipine concentration in serum, CSF and cerebral microdialysate in context of currently effective dose and route of application (oral, IA, IV) is the purpose of this investigation...
March 23, 2017: World Neurosurgery
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