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cerebral vasospasm

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https://www.readbyqxmd.com/read/28904583/giant-unruptured-middle-cerebral-artery-aneurysm-presenting-with-complex-partial-seizure-a-short-review
#1
Guru Dutta Satyarthee, Manmohan Singh
Intracranial aneurysm is a rare cause of seizure although few cases may develop new onset seizure following rupture of aneurysm. The causes of seizure in ruptured aneurysm may be caused due to presence of subarachnoid hemorrhage, intracerebral hematoma, infarct due to progressive vasospasm, worsening of hydrocephalus, or even after surgical craniotomy for clipping of aneurysm. However, incidental aneurysm solely presenting with complex partial seizure is not reported in literature. To the best of knowledge of authors, current case represents the first case as incidental aneurysm presenting with seizure and pertinent literature is briefly reviewed...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28895453/extracranial-internal-carotid-artery-vasospasm-during-thrombectomy
#2
Isamu Miura, Akitsugu Kawashima, Masataka Hayashi, Akane Tanda, Tomomi Ishikawa, Takakazu Kawamata
The use of a stent retriever increases the risk of intracranial vasospasm. Here, we report the case of a man who developed severe vasospasm in a long segment of the extracranial internal carotid artery after mechanical irritation by a stent retriever inserted for the treatment of acute cerebral ischemia. A 47-year-old right-handed man presented with sudden-onset right-sided weakness and difficulty speaking. The patient's National Institutes of Health Stroke Scale score was 6 and he had an Alberta Stroke Program Early Computed Tomography Score of 9...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28893694/altered-expression-of-microrna-15a-and-kruppel-like-factor-4-in-cerebrospinal-fluid-and-plasma-after-aneurysmal-subarachnoid-hemorrhage
#3
Yuichiro Kikkawa, Takeshi Ogura, Hiroyuki Nakajima, Toshiki Ikeda, Ririko Takeda, Hiroaki Neki, Shinya Kohyama, Fumitaka Yamane, Ryota Kurogi, Toshiyuki Amano, Akira Nakamizo, Masahiro Mizoguchi, Hiroki Kurita
BACKGROUND: Cerebral vasospasm (CVS) is a major determinant of prognosis in patients with subarachnoid hemorrhage (SAH). Alteration in the vascular phenotype contributes to development of CVS. However, little is known about the role of microRNAs (miRNAs) in the phenotypic alteration after SAH. We investigated the expression profile of miRNAs and the chronological changes in the expression of microRNA-15a (miR-15a) and Kruppel-like factor 4 (KLF4), a potent regulator of vascular phenotype modulation that modulates the expression of miR-15a, in the plasma and cerebrospinal fluid (CSF) of SAH patients...
September 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28879894/animal-models-for-cerebral-vasospasm-where-do-we-stand
#4
Dhananjaya I Bhat
No abstract text is available yet for this article.
September 2017: Neurology India
https://www.readbyqxmd.com/read/28879893/a-novel-swine-model-of-subarachnoid-hemorrhage-induced-cerebral-vasospasm
#5
Zion Zibly, Lory Fein, Mayur Sharma, Yaron Assaf, Anton Wohl, Sagi Harnof
OBJECTIVE: One of the most serious complications following subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI) secondary to symptomatic vasospasm. An animal model mimicking post SAH vasospasm is essential for enabling the translation of newer technologies from the conceptual phase to animal studies, and eventually to clinical trials. Various animal models of DCI following SAH have been reported, with canine models being the most common. Due to the similarity of the swine cardiovascular system and its dimensions to the human's system, the main objective of this study was to establish a consistent and quantitatively representative model of SAH-induced vasospasm in swine...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28868047/in-premature-newborns-intraventricular-hemorrhage-causes-cerebral-vasospasm-and-associated-neurodisability-via-heme-induced-inflammasome-mediated-interleukin-1-production-and-nitric-oxide-depletion
#6
Michael Eisenhut, Samyami Choudhury
BACKGROUND: Intraventricular hemorrhage (IVH) occurs in 60-70% of neonates weighing 500-750 g and 10-20% of those weighing 1,000-1,500 g. All forms of IVH have been associated with neurocognitive deficits. Both subarachnoid and IVHs have been associated with delayed vasospasm leading to neurological deficits. Pathways linking hemoglobin release from blood clots to vasospasm include heme-induced activation of inflammasomes releasing interleukin-1 (IL-1) that can cause calcium dependent and independent vasospasm...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28867315/soluble-fms-like-tyrosine-kinase-1-sflt-1-and-risk-of-cerebral-vasospasm-after-aneurysmal-subarachnoid-hemorrhage
#7
Christoph J Griessenauer, Michelle H Chua, Khalid A Hanafy, Yaw Tachie Baffour, Ruiya Chen, Robert H LeBlanc, Apar S Patel, Mohamed Salem, S Ananth Karumanchi, Dihua Xu, Ravi Thadhani, Christopher S Ogilvy, Ajith J Thomas
INTRODUCTION: The molecular mechanisms underlying cerebral vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) are incompletely understood. We hypothesized that circulating anti-angiogenic factors, such as soluble Fms-like tyrosine kinase-1 (sFlt-1) and soluble transforming growth factor β (TGFβ) co-receptor, soluble endoglin (sEng), are important markers of their pathophysiology. METHODS: We performed a prospective study in aSAH patients and measured cerebrospinal fluid (CSF) and serum levels of sFlt-1 and sEng on post-bleed day 1 and 6 and correlated levels with incidence and severity of cerebral vasospasm and DCI...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28864867/safety-of-the-solitaire-4%C3%A2-%C3%A3-%C3%A2-40%C3%A2-mm-stent-retriever-in-the-treatment-of-ischemic-stroke
#8
Felix Zibold, Pasquale Mordasini, Pascal Mosimann, Eike Piechowiak, Tomas Dobrocky, Urs Fischer, Marcel Arnold, Sebastian Bellwald, Jan Gralla
PURPOSE: Stent retrievers apply mechanical force to the intracranial vasculature. Our aim was to evaluate the safety and efficacy of the long Solitaire 4 × 40 mm stent retriever for large vessel occlusion in stroke patients. METHODS: We conducted a retrospective analysis of all patients treated for acute ischemic large vessel occlusion stroke with the Solitaire 2 FR 4 × 40 device between May and October 2016 at our institution. Patient-specific data at baseline and at discharge were documented...
September 1, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28862110/severe-cerebral-vasospasm-and-infarction-after-minor-head-trauma
#9
Laura Chu, Mukul Sharma, Ashkan Shoamanesh
No abstract text is available yet for this article.
September 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28852853/predicting-symptomatic-cerebral-vasospasm-after-aneurysmal-subarachnoid-hemorrhage-with-an-artificial-neural-network-in-a-pediatric-population
#10
Jesse Skoch, Rizwan Tahir, Todd Abruzzo, John M Taylor, Mario Zuccarello, Sudhakar Vadivelu
PURPOSE: Artificial neural networks (ANN) are increasingly applied to complex medical problem solving algorithms because their outcome prediction performance is superior to existing multiple regression models. ANN can successfully identify symptomatic cerebral vasospasm (SCV) in adults presenting after aneurysmal subarachnoid hemorrhage (aSAH). Although SCV is unusual in children with aSAH, the clinical consequences are severe. Consequently, reliable tools to predict patients at greatest risk for SCV may have significant value...
August 29, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28843802/a-recurrent-case-of-ischemic-stroke-caused-by-vasospasm-due-to-giant-cell-arteritis
#11
Reina Kawamura, Atsushi Mizuma, Maiko Kouchi, Eiichiro Nagata, Wakoh Takahashi, Shunya Takizawa
A 73-year-old man was admitted with sudden right upper-limb weakness. He had a temporal headache on the left side and had a 4-month history of fever. Meandering of the left temporal artery (TA) with induration and high inflammatory responses (white blood cell count 22,500 per microliter, C-reactive protein 35.0 mg/dL, and elevated sedimentation rate [ESR] 80 mm/h) were observed. Glycometabolism and lipid metabolism were normal, and autoimmune antibodies were negative. Cultivation tests revealed no bacteria in either blood culture or cerebrospinal fluid...
August 23, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28843762/preventing-cerebral-vasospasm-after-aneurysmal-subarachnoid-hemorrhage-with-aggressive-cisternal-clot-removal-and-nicardipine
#12
Nakao Ota, Hidetoshi Matsukawa, Hiroyasu Kamiyama, Toshiyuki Tsuboi, Kosumo Noda, Atsumu Hashimoto, Takanori Miyazaki, Yu Kinoshita, Norihiro Saito, Sadahisa Tokuda, Kyousuke Kamada, Rokuya Tanikawa
BACKGROUND: and Importance: A subarachnoid clot is the strongest predictor of cerebral vasospasm. Our purpose was to analyze the relationship between the number of postoperative cisternal clots and cerebral vasospasm and to assess the efficacy of surgical clot removal. METHODS: The subjects were 158 aneurysmal subarachnoid hemorrhage (SAH) patients. All underwent clipping with cisternal clot removal. The pre- and postoperative number of clots was semiquantitatively analyzed using CT, and cerebral vasospasm and its severity were analyzed using magnetic resonance angiography (MRA) in a blind fashion...
August 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28831694/increased-plasma-galectin-3-preceding-the-development-of-delayed-cerebral-infarction-and-eventual-poor-outcome-in-non-severe-aneurysmal-subarachnoid-hemorrhage
#13
Hirofumi Nishikawa, Yoshinari Nakatsuka, Masato Shiba, Fumihiro Kawakita, Masashi Fujimoto, Hidenori Suzuki
A matricellular protein galectin-3 is involved in tissue injury and inflammation, but the role of galectin-3 remains unclear in aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study was to assess whether acute-stage galectin-3 levels were associated with the subsequent development of neurovascular events and outcome after SAH. This study included 83 consecutive patients diagnosed with aneurysmal SAH of resuscitated World Federation of Neurological Surgeons (WFNS) grades 1-3. Plasma galectin-3 levels were once measured on days 1-3 (the day after clipping or coiling)...
August 22, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28831103/a-novel-fluorescent-imaging-technique-for-assessment-of-cerebral-vasospasm-after-experimental-subarachnoid-hemorrhage
#14
Diane J Aum, Ananth K Vellimana, Itender Singh, Eric Milner, James W Nelson, Byung Hee Han, Gregory J Zipfel
Various techniques have been developed to study changes in the cerebral vasculature in numerous neuropathological processes including subarachnoid hemorrhage (SAH). One of the most widely employed techniques uses India ink-gelatin casting, which presents numerous challenges due to its high viscosity, rapid solidification, and its impact on immunohistochemical analysis. To overcome these limitations, we developed a novel technique for assessing cerebral vasospasm using cerebrovascular perfusion with ROX, SE (5-Carboxy-X-Rhodamine, Succinimidyl Ester), a fluorescent labeling dye...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816832/reversible-splenial-lesion-syndrome-after-intravenous-immunoglobulin-treatment-for-guillain-barre-syndrome
#15
Elif Uygur Kucukseymen, Burcu Yuksel, Fatma Genc, Eylem Ozaydin Goksu, Sevim Yildiz, Yasemin Bicer Gomceli
Reversible corpus callosum splenial (CCS) lesions have been described in patients with varied etiologies. The most common causes of previously reported reversible focal lesions of the CCS are viral encephalitis, antiepileptic drug toxicity/withdrawal, and metabolic disorders. Intravenous immunoglobulin (IVIG) therapy is used for different immune-mediated diseases. It is generally safe, and serious adverse reactions are uncommon. We presented a rare case of disturbed consciousness with reversible CCS lesions after IVIG therapy for Guillain-Barre syndrome in an adult woman...
September 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28812108/ultra-early-detection-of-microcirculatory-injury-as-predictor-of-developing-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#16
Philipp Gölitz, Philip Hoelter, Julie Rösch, Karl Roessler, Frauke Knossalla, Arnd Doerfler
PURPOSE: Delayed cerebral ischemia (DCI) still remains a major complication after subarachnoid hemorrhage (SAH). The aim of our study was to evaluate whether flow analysis of admission digital subtraction angiography (DSA) using parametric color coding (PCC), a postprocessing algorithm, allows ultra-early identification of SAH patients at risk for developing subsequent symptomatic vasospasm. METHODS: In this study 52 patients who suffered SAH from aneurysm rupture, were retrospectively enrolled...
August 15, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28808649/the-effect-of-a-single-dose-dantrolene-in-patients-with-vasospasm-following-aneurysmal-subarachnoid-hemorrhage
#17
Masih Sabouri, Mahmood Momeni, Fariborz Khorvash, Majid Rezvani, Homayon Tabesh
BACKGROUND: Cerebral vasospasm is a prolonged, occasionally severe, but reversible narrowing of the cerebral arteries that begins 3 to 5 days after the hemorrhage becomes maximal at 14 days. This study is designed to evaluate the effect of dantrolene on the reduction of vasospasm following aneurysmal subarachnoid hemorrhage (SAH). MATERIALS AND METHODS: This randomized controlled clinical trial was conducted on 32 patients with proven aneurysms in AL-Zahra hospital during 2011-2013...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28782688/urine-f2-isoprostanes-concentration-as-a-poor-prognostic-factor-after-subarachnoid-haemorrhage
#18
Karol Wiśniewski, Michał Bieńkowski, Bartłomiej Tomasik, Marcin Braun, Ernest J Bobeff, Paweł P Liberski, Dariusz J Jaskólski
BACKGROUND: The role of isoprostanes in cerebral vasospasm (CVS) after aneurysmal subarachnoid haemorrhage (aSAH) has remained controversial. Recent studies have suggested that the level of isoprostanes in cerebral spinal fluid could play a role in aSAH patients outcomes. We have measured their concentration in urine as collection is simple and non-invasive. Due to their biological mechanism of action, it is essential to identify their role in aSAH patients. METHODS: A prospective analysis of clinical data and urine samples of 20 patients with aSAH who underwent microsurgical clipping of the aneurysmal neck between May 2016 and January 2017...
August 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28777022/association-of-cystathionine-beta-synthase-polymorphisms-and-aneurysmal-subarachnoid-hemorrhage
#19
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Mingkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer
OBJECTIVE Cystathionine β-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms on aneurysmal subarachnoid hemorrhage (aSAH) and its clinical sequelae is poorly understood. METHODS Blood samples from all patients enrolled in the CARAS (Cerebral Aneurysm Renin Angiotensin System) study were used for genetic evaluation. The CARAS study prospectively enrolled aSAH patients at 2 academic institutions in the United States from 2012 to 2015...
August 4, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28774294/temperature-variability-in-the-day-night-cycle-is-associated-with-further-intracranial-pressure-during-therapeutic-hypothermia
#20
Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski, Emanuela Keller
BACKGROUND: To assess whether circadian patterns of temperature correlate with further values of intracranial pressure (ICP) in severe brain injury treated with hypothermia. METHODS: We retrospectively analyzed temperature values in subarachnoid hemorrhage patients treated with hypothermia by endovascular cooling. The circadian patterns of temperature were correlated with the mean ICP across the following day (ICP24). RESULTS: We analyzed data from 17 days of monitoring of three subarachnoid hemorrhage patients that underwent aneurysm coiling, sedation and hypothermia due to refractory intracranial hypertension and/or cerebral vasospasm...
August 3, 2017: Journal of Translational Medicine
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