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https://www.readbyqxmd.com/read/28524341/randomized-controlled-study-of-a-novel-triple-nitazoxanide-ntz-containing-therapeutic-regimen-versus-the-traditional-regimen-for-eradication-of-helicobacter-pylori-infection
#1
Mona Ah Shehata, Raghda Talaat, Samah Soliman, Huda Elmesseri, Shaimaa Soliman, Sherief Abd-Elsalam
BACKGROUND: Helicobacter pylori infection has become more and more resistant to conventional first-line treatment regimens. So, there is a considerable interest in evaluating new antibiotic combinations and regimens. Nitazoxanide is an anti-infective drug with demonstrated activity against protozoa and anaerobic bacteria including H. pylori. This work is designed to evaluate the efficacy and safety of a unique triple nitazoxanide-containing regimen as a treatment regimen in Egyptian patients with H...
May 19, 2017: Helicobacter
https://www.readbyqxmd.com/read/28522586/antitumor-synergism-and-enhanced-survival-with-a-tumor-vasculature-targeted-enzyme-prodrug-system-rapamycin-and-cyclophosphamide
#2
John J Krais, Needa Virani, Partick H McKernan, Quang Nguyen, Kar-Ming Fung, Vassilios I Sikavitsas, Carla D Kurkjian, Roger G Harrison
Mutant cystathionine gamma-lyase was targeted to phosphatidylserine exposed on tumor vasculature through fusion with annexin A1 or annexin A5.  Cystathionine gamma-lyase E58N, R118L, and E338N mutations impart non-native methionine gamma-lyase activity, resulting in tumor-localized generation of highly toxic methylselenol upon systemic administration of non-toxic selenomethionine.  The described therapeutic system circumvents systemic toxicity issues using a novel drug delivery/generation approach and avoids the administration of non-native proteins and/or DNA required with other enzyme prodrug systems...
May 18, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28513525/rehabilitation-effect-of-exercise-with-soft-tissue-manipulation-in-patients-with-lumbar-muscle-strain
#3
H Li, H Zhang, S Liu, Y Wang, D Gai, Q Lu, H Gan, Y Shi, W Qi
OBJECTIVE: To study the rehabilitation effect of exercise with soft tissue manipulation therapy for patients with lumbar muscle strain. METHODS: Patients with lumbar muscle strain who met the inclusion criteria for study were randomly divided into control and experimental groups. Conventional therapy (i.e., triple therapy of needle, moxibustion, and cupping jar) was implemented for control group patients with lumbar muscle strain, whereas the combination therapy of exercise with manipulation was implemented for experimental group patients with lumbar muscle strain...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28513523/the-efficacy-of-sequential-therapy-in-eradication-of-helicobacter-pylori-in-turkey
#4
F Harmandar, S U İlikhan, Y Üstüündağn, O Harmandar
BACKGROUND AND AIM: Most of the studies about sequential therapy that have been reported from Turkey were levofloxacin based. We aimed to compare the Helicobacter pylori (H. pylori) eradication rates of standard triple, sequential and quadruple therapies including claritromycin regimes in this study. MATERIALS AND METHODS: A total of 160 patients with dyspeptic symptoms were enrolled to the study. The patients were randomized to four groups of treatment protocols...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28511393/utility-of-tru-cut-biopsy-of-breast-lesions-an-experience-in-a-regional-cancer-center-of-a-developing-country
#5
Sagarika Samantaray, Niharika Panda, Kusumabati Besra, Lucy Pattanayak, Subrat Samantara, Sashibhusan Dash
INTRODUCTION: Tru-cut Needle Biopsy (TCB) is an integral part of triple assessment of breast cancer, which includes clinical assessment, mammography and TCB or Core Needle Biopsy (CNB). The technique is reliable, simple, and reproducible, and inexpensive, which can be adapted even for low-income group of patients and in developing countries. AIM: This study was done to establish the efficacy of TCB of palpable breast lesions in a developing country where mammography is not possible in all cases...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28505287/anti-helicobacter-pylori-activity-of-non-living-heat-killed-form-of-lactobacilli-including-lactobacillus-johnsonii-no-1088
#6
Yuji Aiba, Hiroki Ishikawa, Masayoshi Tokunaga, Yasuhiko Komatsu
Some strains of lactic acid bacteria are reported to inhibit the growth of Helicobacter pylori (H. pylori) and proposed to be useful to support so-called triple therapy for H. pylori. Although most strains must be alive to exert their anti-H. pylori activity, some lactobacilli strains are effective even when dead. One possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with H. pylori. In the present study, we found that a non-living heat-killed form of Lactobacillus johnsonii No...
May 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28497487/systematic-review-with-meta-analysis-the-efficacy-of-vonoprazan-based-triple-therapy-on-helicobacter-pylori-eradication
#7
REVIEW
Y S Jung, E H Kim, C H Park
BACKGROUND: In order to increase eradication rates, vonoprazan, a novel potassium-competitive acid blocker, has been used in Helicobacter pylori eradication therapy. AIM: To summarise the results of the efficacy of vonoprazan-based triple therapy, helping clinicians to better understand the benefit of vonoprazan in the treatment of H. pylori infection. METHODS: We conducted a systematic literature search on MEDLINE, EMBASE, and the Cochrane Library using the primary keywords "vonoprazan," "takecab", "TAK-438," "potassium," "competitive," "potassium-competitive," "Helicobacter," and "pylori...
May 12, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28493953/the-association-between-vaca-or-caga-status-and-eradication-outcome-of-helicobacter-pylori-infection-a-meta-analysis
#8
Dan Wang, Qiuping Li, Yuehua Gong, Yuan Yuan
BACKGROUND: H. pylori virulence factors, especially vacA and cagA are important in gastroduodenal disease pathogenesis and affect cure rates. This meta-analysis aimed to clarify the association between vacA or cagA status and eradication outcome of H. pylori infection. METHODS: A literature search was performed using electronic databases to identify studies. Twenty-six prospective studies were determined eligible. Meta-analytical techniques were conducted to calculate eradication rates and pooled relative ratios (RR)...
2017: PloS One
https://www.readbyqxmd.com/read/28493185/dietary-pufa-increase-apoptosis-in-stomach-of-patients-with-dyspeptic-symptoms-and-infected-with-h-pylori
#9
Rasoul Sharifi, Mohammad Nouri, Akram Eidi, Zahra Noormohammadi, Homayun Dolatkhah, Masoud Shirmohammadi
Drug-resistant strains of Helicobacter pylori and poor treatment response are the main reasons for the failure in eradicating it in patients. Polyunsaturated fatty acids (PUFA) have an inhibitory effect on bacterial growth. The aim of this study was to investigate the effect of PUFA in combination with standard triple therapy on apoptosis in H. pylori infected subjects with dyspeptic symptoms. This study was a double-blind clinical trial in which 34 H. pylori infected subjects with dyspeptic symptoms were randomly divided into two groups of 17 patients...
May 10, 2017: Lipids
https://www.readbyqxmd.com/read/28492711/curcumin-in-combination-with-triple-therapy-regimes-ameliorates-oxidative-stress-and-histopathologic-changes-in-chronic-gastritis-associated-helicobacter-pylori-infection
#10
Arezu Judaki, Asghar Rahmani, Jalil Feizi, Khairollah Asadollahi, Mohammad Reza Hafezi Ahmadi
BACKGROUND: Helicobacter pylori (H. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers. OBJECTIVE: The aim of this study was finding the effects of curcumin on oxidative stress and histological changes in chronic gastritis associated with H. pylori. METHODS: In a randomized clinical trial, patients were divided into two groups: a standard triple therapy group and triple therapy with curcumin group. Endoscopic and histological examinations were measured for all patients before and after 8 weeks...
May 8, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28481366/the-zinc-finger-transcriptional-factor-slug-transcriptionally-downregulates-er%C3%AE-by-recruiting-lysine-specific-demethylase-1-in-human-breast-cancer
#11
J-W Bai, M-N Chen, X-L Wei, Y-Ch Li, H-Y Lin, M Chen, J-W Li, C-W Du, K Man, G-J Zhang
Estrogen receptor α (ERα) is related with epithelial-mesenchymal transition, invasion and metastasis, and serves as an important therapeutic predictor and prognostic factor in breast cancer patients. The triple negative breast cancer (TNBC) is characterized by loss of hormone receptors and human epidermal growth factor receptor 2 (Her2), and lacks effective targeted therapy with poor prognosis. Unfortunately, the molecular mechanisms of ERα deficiency, which becomes hormone independent and results in resistance to endocrine therapy, remain to be elucidated in breast cancer...
May 8, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28464347/optimization-strategies-aimed-to-increase-the-efficacy-of-h-%C3%A2-pylori-eradication-therapies
#12
REVIEW
Javier P Gisbert, Adrian G McNicholl
BACKGROUND: As with any other infectious disease, we should aim for treatments offering ≥90% Helicobacter pylori eradication rates in clinical practice. AIM: To summarize optimization strategies aimed to increase the efficacy of H. pylori eradication therapies. METHODS: A systematic bibliographic search (in PubMed up to August 2016) was designed to identify studies investigating optimization strategies aimed to increase the efficacy of H...
May 2, 2017: Helicobacter
https://www.readbyqxmd.com/read/28457713/management-of-helicobacter-pylori-in-the-united-states-results-from-a-national-survey-of-gastroenterology-physicians
#13
Traci T Murakami, Rebecca A Scranton, Heidi E Brown, Robin B Harris, Zhao Chen, Sunitha Musuku, Eyal Oren
BACKGROUND AND AIMS: We sought to determine current knowledge and practices among gastroenterology physicians and assess adherence to current guidelines for H. pylori management. METHODS: Online surveys were distributed in 2014 to practicing gastroenterology physicians for information related to the diagnosis and treatment of H. pylori infection. RESULTS: A total of 582 completed surveys were reviewed. The H. pylori screening test used "almost always" was gastric biopsy obtained during endoscopy (histology) (59%) followed by stool antigen test (20%)...
April 27, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28427781/smoking-increases-the-likelihood-of-helicobacter-pylori-treatment-failure
#14
David Itskoviz, Doron Boltin, Haim Leibovitzh, Tsachi Tsadok Perets, Doron Comaneshter, Arnon Cohen, Yaron Niv, Zohar Levi
BACKGROUND AND AIMS: Data regarding the impact of smoking on the success of Helicobacter pylori (H. pylori) eradication are conflicting, partially due to the fact that sociodemographic status is associated with both smoking and H. pylori treatment success. We aimed to assess the effect of smoking on H. pylori eradication rates after controlling for sociodemographic confounders. METHODS: Included were subjects aged 15 years or older, with a first time positive C(13)-urea breath test (C(13)-UBT) between 2007 to 2014, who underwent a second C(13)-UBT after receiving clarithromycin-based triple therapy...
March 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28425141/efficacy-of-helicobacter-pylori-eradication-therapies-in-korea-a-systematic-review-and-network-meta-analysis
#15
REVIEW
Yoon Suk Jung, Chan Hyuk Park, Jung Ho Park, Eunwoo Nam, Hang Lak Lee
BACKGROUND: The efficacy of Helicobacter pylori eradication regimens may depend on the country where the studies were performed because of the difference in antibiotic resistance. We aimed to analyze the efficacy of H. pylori eradication regimens in Korea where clarithromycin resistance rate is high. METHODS: We searched for all relevant randomized controlled trials published until November 2016 that investigated the efficacy of H. pylori eradication therapies in Korea...
April 19, 2017: Helicobacter
https://www.readbyqxmd.com/read/28422487/stepwise-deoxygenation-of-nitrite-as-a-route-to-two-families-of-ruthenium-corroles-group-8-periodic-trends-and-relativistic-effects
#16
Abraham B Alemayehu, Hugo Vazquez-Lima, Kevin J Gagnon, Abhik Ghosh
Given the many applications of ruthenium porphyrins, the rarity of ruthenium corroles and the underdeveloped state of their chemistry are clearly indicative of an area ripe for significant breakthroughs. The tendency of ruthenium corroles to form unreactive metal-metal-bonded dimers has been recognized as a key impediment in this area. Herein, by exposing free-base meso-tris(p-X-phenyl)corroles, H3[TpXPC] (X = CF3, H, Me, and OMe), and [Ru(COD)Cl2]x in refluxing 2-methoxyethanol to nitrite, we have been able to reliably intercept the series Ru[TpXPC](NO) in a matter of seconds to minutes and subsequently Ru(VI)[TpXPC](N), the products of a second deoxygenation, over some 16 h...
April 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28407007/polaprezinc-combined-with-clarithromycin-based-triple-therapy-for-helicobacter-pylori-associated-gastritis-a-prospective-multicenter-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Bei Tan, Han-Qing Luo, Hong Xu, Nong-Hua Lv, Rui-Hua Shi, He-Sheng Luo, Jian-Sheng Li, Jian-Lin Ren, Yi-You Zou, Yan-Qing Li, Feng Ji, Jing-Yuan Fang, Jia-Ming Qian
The efficacy and safety of polaprezinc combined with triple therapy was compared with triple therapy alone in the eradication of Helicobacter pylori. A randomized, parallel-group, open-label, controlled, prospective multicenter study was conducted in 11 cities in China. Treatment-naive patients with H. pylori-associated gastritis were randomly assigned to one of three arms for a 14-day treatment: Arm A triple therapy (omeprazole 20 mg, amoxicillin 1 g, and clarithromycin 500 mg, each twice daily) plus polaprezinc 75 mg twice daily; Arm B triple therapy plus polaprezinc 150 mg twice daily, or Arm C triple therapy alone...
2017: PloS One
https://www.readbyqxmd.com/read/28406585/association-of-helicobacter-pylori-with-parkinson-s-disease
#18
Kandadai Rukmini Mridula, Rupam Borgohain, Vupparalli Chandrasekhar Reddy, Venkata Chandrasekhar Srinivasarao Bandaru, Turaga Suryaprabha
BACKGROUND AND PURPOSE: Parkinson's disease (PD) is a major neurological disorder that requires lifelong treatment, and the combined presence of Helicobacter pylori (H. pylori) infection can increase the required anti-PD medications. We aim to investigate the effect of H. pylori infection in Indian PD patients. METHODS: We prospectively recruited 36 PD patients from December 2007 to January 2011. All patients underwent a detailed neurological evaluation and serological examination for H...
April 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28402317/simultaneous-and-quantitative-monitoring-of-co-cultured-pseudomonas-aeruginosa-and-staphylococcus-aureus-with-antibiotics-on-a-diffusometric-platform
#19
Chih-Yao Chung, Jhih-Cheng Wang, Han-Sheng Chuang
Successful treatments against bacterial infections depend on antimicrobial susceptibility testing (AST). However, conventional AST requires more than 24 h to obtain an outcome, thereby contributing to high patient mortality. An antibiotic therapy based on experiences is therefore necessary for saving lives and escalating the emergence of multidrug-resistant pathogens. Accordingly, a fast and effective drug screen is necessary for the appropriate administration of antibiotics. The mixed pathogenic nature of infectious diseases emphasizes the need to develop an assay system for polymicrobial infections...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28373764/effect-of-treatment-failure-on-the-caga-epiya-motif-in-helicobacter-pylori-strains-from-colombian-subjects
#20
Javier Andres Bustamante-Rengifo, Andres Jenuer Matta, Alvaro Jairo Pazos, Luis Eduardo Bravo
AIM: To evaluate effect of treatment failure on cagA and vacA genotypes in Helicobacter pylori (H. pylori) isolates from Colombia. METHODS: One hundred and seventy-six participants infected with H. pylori from Colombia were treated during 14 d with the triple-standard therapy. Six weeks later, eradication was evaluated by (13)C-Urea breath test. Patients with treatment failure were subjected to endoscopy control; biopsies obtained were used for histopathology and culture...
March 21, 2017: World Journal of Gastroenterology: WJG
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