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https://www.readbyqxmd.com/read/29784737/nccn-guidelines-updates-breast-cancer
#1
Sharon H Giordano, Anthony D Elias, William J Gradishar
The emergence of CDK4/6 inhibitors has changed the treatment algorithm for advanced/metastatic estrogen receptor-positive breast cancer. In pivotal trials of palbociclib, ribociclib, and abemaciclib, doubling in progression-free survival has been seen. All 3 agents in this class are now included in the NCCN Guidelines for Breast Cancer, and clinicians should be incorporating these agents into their treatment algorithms. The other important issue in this breast cancer setting is extended duration of endocrine therapy...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29769116/efficacies-of-cabotegravir-and-bictegravir-against-drug-resistant-hiv-1-integrase-mutants
#2
Steven J Smith, Xue Zhi Zhao, Terrence R Burke, Stephen H Hughes
BACKGROUND: Integrase strand transfer inhibitors (INSTIs) are the class of antiretroviral (ARV) drugs most recently approved by the FDA for the treatment of HIV-1 infections. INSTIs block the strand transfer reaction catalyzed by HIV-1 integrase (IN) and have been shown to potently inhibit infection by wild-type HIV-1. Of the three current FDA-approved INSTIs, Dolutegravir (DTG), has been the most effective, in part because treatment does not readily select for resistant mutants. However, recent studies showed that when INSTI-experienced patients are put on a DTG-salvage therapy, they have reduced response rates...
May 16, 2018: Retrovirology
https://www.readbyqxmd.com/read/29765318/utility-of-a-novel-three-dimensional-and-dynamic-3dd-cell-culture-system-for-pk-pd-studies-evaluation-of-a-triple-combination-therapy-at-overcoming-anti-her2-treatment-resistance-in-breast-cancer
#3
Anusha Ande, Tanaya R Vaidya, Bao N Tran, Michael Vicchiarelli, Ashley N Brown, Sihem Ait-Oudhia
Background: Emergence of Human epidermal growth factor receptor 2 (HER2) therapy resistance in HER2-positive (HER2+) breast cancer (BC) poses a major clinical challenge. Mechanisms of resistance include the over-activation of the PI3K/mTOR and Src pathways. This work aims to investigate a novel combination therapy that employs paclitaxel (PAC), a mitotic inhibitor, with everolimus (EVE), an mTOR inhibitor, and dasatinib (DAS), an Src kinase inhibitor, as a modality to overcome resistance. Methods: Static (two dimensional, 2D) and three-dimensional dynamic (3DD) cell culture studies were conducted using JIMT-1 cells, a HER2+ BC cell line refractory to HER2 therapies...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29746779/energy-metabolism-drugs-block-triple-negative-breast-metastatic-cancer-cell-phenotype
#4
Silvia Cecilia Pacheco-Velazquez, Diana Xochiquetzal Robledo-Cadena, Ileana Hernández-Reséndiz, Juan Carlos Gallardo-Pérez, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
To establish alternative targeted therapies against triple negative (TN) breast cancer, (1) the energy metabolism and (2) the sensitivity of cell growth, migration and invasiveness towards metabolic, canonical and NSAID inhibitors was analyzed in MDA-MB-231 and MDA-MB-468, two TN metastatic breast cancer cell lines, under both normoxia (21% O2) and hypoxia (0.1% O2). For comparative purposes, analysis was also carried out in the less-metastatic breast MCF-7 cancer cells. Under normoxia, oxidative phosphorylation (OxPhos) was significantly higher (2-times) in MDA-MB-468 than in MDA-MB-231 and MCF-7 whereas their glycolytic fluxes and OxPhos and glycolytic protein contents were all similar...
May 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29721153/application-of-polymersomes-engineered-to-target-p32-protein-for-detection-of-small-breast-tumors-in-mice
#5
Lorena Simón-Gracia, Pablo Scodeller, Sergio Salazar Fuentes, Vanessa Gómez Vallejo, Xabier Ríos, Eneko San Sebastián, Valeria Sidorenko, Desirè Di Silvio, Meina Suck, Federica De Lorenzi, Larissa Yokota Rizzo, Saskia von Stillfried, Kalle Kilk, Twan Lammers, Sergio E Moya, Tambet Teesalu
Triple negative breast cancer (TNBC) is the deadliest form of breast cancer and its successful treatment critically depends on early diagnosis and therapy. The multi-compartment protein p32 is overexpressed and present at cell surfaces in a variety of tumors, including TNBC, specifically in the malignant cells and endothelial cells, and in macrophages localized in hypoxic areas of the tumor. Herein we used polyethylene glycol-polycaprolactone polymersomes that were affinity targeted with the p32-binding tumor penetrating peptide LinTT1 (AKRGARSTA) for imaging of TNBC lesions...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29707134/a-jurkat-76-based-triple-parameter-reporter-system-to-evaluate-tcr-functions-and-adoptive-t-cell-strategies
#6
Sandra Rosskopf, Judith Leitner, Wolfgang Paster, Laura T Morton, Renate S Hagedoorn, Peter Steinberger, Mirjam H M Heemskerk
Adoptive T cell therapy using TCR transgenic autologous T cells has shown great potential for the treatment of tumor patients. Thorough characterization of genetically reprogrammed T cells is necessary to optimize treatment success. Here, we describe the generation of triple parameter reporter T cells based on the Jurkat 76 T cell line for the evaluation of TCR and chimeric antigen receptor functions as well as adoptive T cell strategies. This Jurkat subline is devoid of endogenous TCR alpha and TCR beta chains, thereby circumventing the problem of TCR miss-pairing and unexpected specificities...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29703387/food-drug-interactions-precipitated-by-fruit-juices-other-than-grapefruit-juice-an-update-review
#7
REVIEW
Meng Chen, Shu-Yi Zhou, Erlinda Fabriaga, Pian-Hong Zhang, Quan Zhou
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29700392/ephb6-augments-both-development-and-drug-sensitivity-of-triple-negative-breast-cancer-tumours
#8
Behzad M Toosi, Amr El Zawily, Luke Truitt, Matthew Shannon, Odette Allonby, Mohan Babu, John DeCoteau, Darrell Mousseau, Mohsin Ali, Tanya Freywald, Amanda Gall, Frederick S Vizeacoumar, Morgan W Kirzinger, C Ronald Geyer, Deborah H Anderson, TaeHyung Kim, Alana L Welm, Peter Siegel, Franco J Vizeacoumar, Anthony Kusalik, Andrew Freywald
Triple-negative breast cancer (TNBC) tumours that lack expression of oestrogen, and progesterone receptors, and do not overexpress the HER2 receptor represent the most aggressive breast cancer subtype, which is characterised by the resistance to therapy in frequently relapsing tumours and a high rate of patient mortality. This is likely due to the resistance of slowly proliferating tumour-initiating cells (TICs), and understanding molecular mechanisms that control TICs behaviour is crucial for the development of effective therapeutic approaches...
April 27, 2018: Oncogene
https://www.readbyqxmd.com/read/29699490/the-magnitude-of-antibiotic-resistance-to-helicobacter-pylori-in-africa-and-identified-mutations-which-confer-resistance-to-antibiotics-systematic-review-and-meta-analysis
#9
Hyasinta Jaka, Jee Ah Rhee, Linda Östlundh, Luke Smart, Robert Peck, Andreas Mueller, Christa Kasang, Stephen E Mshana
BACKGROUND: Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibiotic resistance in Africa is high with unclear information regarding the real magnitude. This systematic review and meta-analysis was conducted to investigate the magnitude of H.pylori antibiotic resistance in Africa to gain insight of the extent of the problem among H.pylori naïve treatment patients. METHOD: The search was performed in the academic databases, Embase, PubMed, Web of Science and Africa Wide Information...
April 24, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29696736/bismuth-improves-efficacy-of-proton-pump-inhibitor-clarithromycin-metronidazole-triple-helicobacter-pylori-therapy-despite-a-high-prevalence-of-antimicrobial-resistance
#10
Xiaohua Long, Qi Chen, Lou Yu, Xiao Liang, Wenzhong Liu, Hong Lu
BACKGROUND: Helicobacter pylori (H. pylori) eradication has become increasingly difficult especially for penicillin allergy patients. AIMS: To evaluate the efficacy of adding bismuth or high-dose metronidazole to an H. pylori eradication regimen containing a proton-pump inhibitor, clarithromycin, and metronidazole in patients allergic to penicillin. METHODS: Pilot study in which penicillin-allergic, treatment-naive subjects were randomized (1:1) to 14-day esomeprazole (20 mg q12h), clarithromycin (500 mg q12h), and high dose of metronidazole (400 mg q6h) with (BECM group) or without (ECM group) bismuth (600 mg q12h)...
April 25, 2018: Helicobacter
https://www.readbyqxmd.com/read/29696074/glycosylated-extracellular-vesicles-released-by-glioblastoma-cells-are-decorated-by-ccl18-allowing-for-cellular-uptake-via-chemokine-receptor-ccr8
#11
Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H W Crommentuijn, Laurine E Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H van der Meulen-Muileman, Rogier M Reijmers, Toin H van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W Peter Vandertop, David P Noske, Victor W van Beusechem, Jacco van Rheenen, D Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger
Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour progression and therapy resistance. Through RNAi screening, we identified a novel EV uptake mechanism involving a triple interaction between the chemokine receptor CCR8 on the cells, glycans exposed on EVs and the soluble ligand CCL18. This ligand acts as bridging molecule, connecting EVs to cancer cells. We show that glioblastoma EVs promote cell proliferation and resistance to the alkylating agent temozolomide (TMZ)...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29689158/synergistically-enhancing-therapeutic-effect-of-radiation-therapy-with-radiation-activatable-and-reactive-oxygen-species-releasing-nanostructures
#12
Kai Cheng, Michael Sano, Cesare H Jenkins, Guanglei Zhang, Don Vernekohl, Wei Zhao, Chenxi Wei, Yan Zhang, Zhe Zhang, Yijin Liu, Zhen Cheng, Lei Xing
Nanoparticle-based radio-sensitizers can amplify the effects of radiation therapy on tumor tissue even at relatively low concentrations while reducing the potential side effects to healthy surrounding tissues. In this study, we investigated a hybrid anisotropic nanostructure, composed of gold (Au) and titanium dioxide (TiO2), as a radio-sensitizer for radiation therapy of triple negative breast cancer (TNBC). In contrast to other gold based radio sensitizers, dumbbell-like Au-TiO2 nanoparticles (DATs) show a synergistic therapeutic effect on radiation therapy, mainly because of strong asymmetric electric coupling between the high atomic number metals and dielectric oxides at their interfaces...
April 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29684969/-the-efficacy-of-rebamipide-or-ecabet-sodium-supplementation-for-helicobacter-pylori-eradication-therapy-compared-with-quadruple-concomitant-regimen
#13
Joonhwan Kim, Kyungwon Kim, Jun Soo Lee, Su Young Kim, Kyung Oh Kim, Yoon Jae Kim, Kwang An Kwon, Dong Kyun Park, Jun Won Chung
Background/Aims: Although some previous studies reported that a treatment combined with mucoprotective agent could improve the eradication rate in dual or triple therapy, there are other reports that question the efficacy of combining these drugs in concomitant therapy (CoCTx). The aim of this study was to investigate the effects of rebamipide or ecabet on the Helicobacter pylori ( H. pylori ) eradication combined with CoCTx. Methods: We retrospectively reviewed the medical records of 277 patients with proven H...
April 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29682242/eradication-of-helicobacter-pylori-in-iran-a-review
#14
REVIEW
Hafez Fakheri, Mehdi Saberi Firoozi, Zohreh Bari
Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections, affecting almost half of the world's population. It is associated with peptic ulcer disease, gastric adenocarcinoma, and lymphoma. In Iran, the prevalence of H. pylori infection has been reported to be between 36% and 90% in different geographic regions. Several studies have assessed the efficacy of different therapeutic options for firstline and second-line H. pylori eradication in Iran; however, the results are conflicting...
January 2018: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29679144/antithrombotic-therapy-in-patients-with-non-valvular-atrial-fibrillation-undergoing-percutaneous-coronary-intervention-should-we-change-our-practice-after-the-pioneer-af-pci-and-re-dual-pci-trials
#15
D Duerschmied, J Brachmann, H Darius, N Frey, H A Katus, W Rottbauer, A Schäfer, H Thiele, C Bode, Uwe Zeymer
The number of patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) is increasing. Since these patients have a CHA2 DS2 -VASc score of 1 or higher, they should be treated with oral anticoagulation to prevent stroke. However, combination therapy with oral anticoagulation for prevention of embolic stroke and dual platelet inhibition for prevention of coronary thrombosis significantly increases bleeding complications. The optimal combination, intensity and duration of antithrombotic combination therapy is still not known...
April 20, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29675931/efficacy-studies-of-sclerotium-rolfsii-lectin-on-breast-cancer-using-nod-scid-mouse-model
#16
Prajna Hegde, Jagadeesh Narasimhappagari, Bale M Swamy, Shashikala R Inamdar
Expression of altered glycans like TF, Tn and sTn antigens has been observed in a number of carcinomas which are targeted in cancer therapy. Sclerotium rolfsii lectin (SRL) is known to recognize TF and its substituted forms. Clinical potential of SRL has been demonstrated by studying its interaction with different types of cancer cells. Here we report, in vitro studies of SRL on breast cancer MDA-MB-468 cells and in vivo studies with MCF-7 xenografts. In vitro growth inhibitory studies of SRL on metastatic triple negative breast cancer MDA-MB-468 cells was performed by MTT assay, flow cytometry, adhesion and CAM assay...
April 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29673735/efficacy-and-tolerability-of-triple-drug-therapy-with-albendazole-pyrantel-pamoate-and-oxantel-pamoate-compared-with-albendazole-plus-oxantel-pamoate-pyrantel-pamoate-plus-oxantel-pamoate-and-mebendazole-plus-pyrantel-pamoate-and-oxantel-pamoate-against-hookworm
#17
Wendelin Moser, Somphou Sayasone, Syda Xayavong, Bangon Bounheuang, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Albendazole and mebendazole are commonly used to control hookworm, but have shortcomings in their efficacy profiles. We assessed whether triple drug therapy (TDT) with albendazole, pyrantel pamoate, and oxantel pamoate was more effective than the co-administration of two drugs for the treatment of hookworm infections. METHODS: A randomised, single-blind trial was done from Sept 27 until Nov 17, 2017, in Laos. Children (6-15 years) from six schools were invited to participate...
April 16, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29668889/safety-and-efficacy-of-dual-vs-triple-antithrombotic-therapy-in-patients-with-atrial-fibrillation-following-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#18
Harsh B Golwala, Christopher P Cannon, Ph Gabriel Steg, Gheorghe Doros, Arman Qamar, Stephen G Ellis, Jonas Oldgren, Jurrien M Ten Berg, Takeshi Kimura, Stefan H Hohnloser, Gregory Y H Lip, Deepak L Bhatt
Aims: Of patients with atrial fibrillation (AF), approximately 10% undergo percutaneous coronary intervention (PCI). We studied the safety and efficacy of dual vs. triple antithrombotic therapy (DAT vs. TAT) in this population. Methods and results: A systematic review and meta-analysis was conducted using PubMed, Embase, EBSCO, Cochrane database of systematic reviews, Web of Science, and relevant meeting abstracts for Phase 3, randomized trials that compared DAT vs...
April 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29662198/the-mir-106b-25-cluster-mediates-breast-tumor-initiation-through-activation-of-notch1-via-direct-repression-of-nedd4l
#19
A L Guarnieri, C G Towers, D J Drasin, M U J Oliphant, Z Andrysik, T J Hotz, R L Vartuli, E S Linklater, A Pandey, S Khanal, J M Espinosa, H L Ford
Tumor-initiating cells (TIC) represent a subset of tumor cells with increased self-renewal capability. TICs display resistance to frontline cancer treatment and retain the ability to repopulate a tumor after therapy, leading to cancer relapse. NOTCH signaling has been identified as an important driver of the TIC population, yet mechanisms governing regulation of this pathway in cancer remain to be fully elucidated. Here we identify a novel mechanism of NOTCH regulation and TIC induction in breast cancer via the miR-106b-25 miRNA cluster...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29652033/the-effect-of-virulence-genotypes-of-helicobacter-pylori-on-eradication-therapy-in-children
#20
Shuang-Hong Zhang, Xuan Zhu, Bi-Min Li, Hong Li
Background/Aim: It is important to eradicate Helicobacter pylori at an early stage in patients during childhood to potentially prevent the development of H. pylori-related diseases. Studies have demonstrated that the virulence genotype of H. pylori influences the efficacy of eradication therapy. The efficacy of triple therapy has decreased significantly, which has seriously affected the clinical outcome of children with H. pylori infection. In this study we aimed to investigate the influence of virulence genotypes of H...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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