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https://www.readbyqxmd.com/read/28543854/endocardial-fibroelastosis-is-secondary-to-hemodynamic-alterations-in-the-chick-embryonic-model-of-hypoplastic-left-heart-syndrome
#1
Zivorad Pesevski, Alena Kvasilova, Tereza Stopkova, Ondrej Nanka, Eliska Drobna Krejci, Christine Buffinton, Radka Kockova, Adam Eckhardt, David Sedmera
BACKGROUND: Endocardial fibroelastosis (EFE) is a diffuse thickening of the ventricular endocardium, causing myocardial dysfunction and presenting as unexplained heart failure in infants and children. One of the postulated causes is persistent and increased wall tension in the ventricles. RESULTS: To examine whether reduced ventricular pressure in a chick model of hypoplastic left heart syndrome induced by left atrial ligation (LAL) at ED4 is associated with EFE at later stages, myocardial fibrosis was evaluated by histology and immunoconfocal microscopy and mass spectrometry (MS) at ED12...
May 20, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28530259/approach-to-the-correction-of-drooping-tip-common-problems-and-solutions
#2
P G Giacomini, S Rubino, S Mocella, M Pascali, S Di Girolamo
The drooping tip deformity is both a bothersome aesthetic feature and functional impairment of the nose. Both static and dynamic factors may affect tip appearance and it seems logical to take into account these factors when planning correction of drooping tip. Many studies have examined this topic, but its treatment remains controversial. In order to make nasal tip surgery successful, it is useful to identify the keystone anatomical characteristics of the tip itself. Naso-labial angle, nostril axis, tip rotation angle according to Frankfort plane and columellar-facial angle may be measured to assess nasal tip position...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28530218/visualization-of-penile-suspensory-ligamentous-system-based-on-visible-human-data-sets
#3
Xianzhuo Chen, Yi Wu, Ling Tao, Yan Yan, Jun Pang, Shaoxiang Zhang, Shirong Li
BACKGROUND The aim of this study was to use a three-dimensional (3D) visualization technology to illustrate and describe the anatomical features of the penile suspensory ligamentous system based on the Visible Human data sets and to explore the suspensory mechanism of the penis for the further improvement of the penis-lengthening surgery. MATERIAL AND METHODS Cross-sectional images retrieved from the first Chinese Visible Human (CVH-1), third Chinese Visible Human (CVH-3), and Visible Human Male (VHM) data sets were used to segment the suspensory ligamentous system and its adjacent structures...
May 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28520850/anatomical-study-of-temporal-fat-compartments-and-its-clinical-application-for-temporal-fat-grafting
#4
Ru-Lin Huang, Yun Xie, Wenjin Wang, Tanja Herrler, Jia Zhou, Peijuan Zhao, Lee L Q Pu, Qingfeng Li
Background: Low satisfaction rates and severe complications are two major limitations for temporal hollowing augmentation using autologous fat grafting. Despite fat compartments in temporal region have been reported, its clinical applied anatomy for fat grafting have not been the subject of studies that show its benefits objectively and statistically. Objectives: To investigate temporal fat compartments and relative neurovascular structures in cadavers, developing a safe and effective fat grafting technique for temporal hollowing augmentation...
May 18, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28512038/involvement-of-the-oxytocin-system-in-the-nucleus-accumbens-in-the-regulation-of-juvenile-social-novelty-seeking-behavior
#5
Caroline J W Smith, Jazmin N Mogavero, Maxwell T Tulimieri, Alexa H Veenema
Exploration of novel environments, stimuli, and conspecifics is highly adaptive during the juvenile period, as individuals transition from immaturity to adulthood. We recently showed that juvenile rats prefer to interact with a novel individual over a familiar cage mate. However, the neural mechanisms underlying this juvenile social novelty-seeking behavior remain largely unknown. One potential candidate is the oxytocin (OXT) system, given its involvement in various motivated social behaviors. Here, we show that administration of the specific oxytocin receptor antagonist desGly-NH2,d(CH2)5-[Tyr(Me)(2),Thr(4)]OVT reduces social novelty seeking-behavior in juvenile male rats when injected into the nucleus accumbens (10ng/0...
May 20, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28508318/trpc-channels-and-epilepsy
#6
Fang Zheng
Accumulating evidence suggest that TRPC channels play critical roles in various aspects of epileptogenesis. TRPC1/4 channels are major contributors to nonsynaptically derived epileptiform burst firing in the CA1 and the lateral septum. TRPC7 channels play a critical role in synaptically derived epileptiform burst firing. The reduction of spontaneous epileptiform bursting in the CA3 is correlated to a reduction in pilocarpine-induced SE in vivo in TRPC7 knockout mice. TRPC channels are also significant contributors to SE-induced neuronal cell death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28500177/efficacy-of-an-anatomical-approach-in-radiofrequency-catheter-ablation-of-idiopathic-ventricular-arrhythmias-originating-from-the-left-ventricular-outflow-tract
#7
Takumi Yamada, Naoki Yoshida, Harish Doppalapudi, Silvio H Litovsky, H Thomas McElderry, G Neal Kay
BACKGROUND: When anatomic obstacles preclude radiofrequency catheter ablation of idiopathic ventricular arrhythmias (VAs) originating from the left ventricular outflow tract (LVOT), an alternative approach from the anatomically opposite side (endocardial versus epicardial or above versus below the aortic valve) may be considered (anatomic ablation). The purpose of this study was to investigate the efficacy of an anatomic ablation in idiopathic LVOT VAs. METHODS AND RESULTS: We studied 229 consecutive patients with idiopathic LVOT VAs...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28476777/disease-stage-dependent-changes-in-cardiac-contractile-performance-and-oxygen-utilization-underlie-reduced-myocardial-efficiency-in-human-inherited-hypertrophic-cardiomyopathy
#8
Ahmet Güçlü, Paul Knaapen, Hendrik J Harms, Rahana Y Parbhudayal, Michelle Michels, Adriaan A Lammertsma, Albert C van Rossum, Tjeerd Germans, Jolanda van der Velden
BACKGROUND: Reduced myocardial efficiency represents a target for therapy in hypertrophic cardiomyopathy although therapeutic benefit may depend on disease stage. Here, we determined disease stage-dependent changes in myocardial efficiency and effects of myectomy surgery. METHODS AND RESULTS: Myocardial external efficiency (MEE) was determined in 27 asymptomatic mutation carriers (genotype positive/phenotype negative), 10 patients with hypertrophic obstructive cardiomyopathy (HOCM), 10 patients with aortic valve stenosis, and 14 healthy individuals using [(11)C]-acetate positron emission tomography and cardiovascular magnetic resonance imaging...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28476679/focal-atrial-tachycardias-from-the-para-hisian-region-strategies-for-mapping-and-catheter-ablation
#9
Jian-du Yang, Qi Sun, Xiao-Gang Guo, Gong-Bu Zhou, Xu Liu, Bin Luo, Hui-Qiang Wei, Jackson J Liang, Shu Zhang, Jian Ma
BACKGROUND: Focal atrial tachycardias (ATs) from the para-Hisian region can be successfully ablated from the right atrial septum (RAS), non-coronary cusp (NCC), and right middle septum (RMS). The optimal mapping and ablation strategy for ATs from these sites remains unclear. OBJECTIVE: We aimed to investigate the electrophysiologic characteristics and optimal ablation sites of para-Hisian ATs from the RAS, RMS, and NCC. METHODS: A total of 362 patients with ATs undergoing radiofrequency catheter ablation of ATs were included...
May 2, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28474294/influence-of-deviated-nasal-septum-on-nasal-epithelium-an-analysis
#10
Lakshit Kumar, Basavaraj P Belaldavar, Hema Bannur
Nasal obstruction is one of the most common complaint that ENT surgeon faces in his day to day practice. Deviated nasal septum is the most common cause for the nasal obstruction. It causes altered airflow dynamics which leads to various histopathological changes in nasal mucosa.Histopathological changes like lymphocytic infiltration and squamous metaplasia were studied and comparison was done between convex and concave side. A prospective randomized study conducted on 42 patients of deviated nasal septum from January 2015 to December 2015 selected from inpatient department of Otorhinolaryngology, KLES Dr...
May 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28470551/nuclear-derivatives-and-axonal-projections-originating-from-rhombomere-4-in-the-mouse-hindbrain
#11
Maria Di Bonito, Michèle Studer, Luis Puelles
The r4-derived territory is located in the pontine region of the brainstem, forming a wedge-shaped slice that broadens from the choroidal roof to the ventral midline. R4-derived neuronal populations migrate radially inside and tangentially outside this rhombomere, forming nuclei of the sensorimotor auditory, vestibular, trigeminal and reticular systems. R4-derived fibre tracts contribute to the lateral lemniscus, the trigeminothalamic tracts, the medial tegmental tract and the medial forebrain bundle, which variously project to the midbrain, thalamus, hypothalamus and telencephalon...
May 3, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28458730/complications-during-maxillary-sinus-augmentation-associated-with-interfering-septa-a-new-classification-of-septa
#12
Tassos Irinakis, Valentin Dabuleanu, Salwa Aldahlawi
PURPOSE: A new classification of maxillary sinus interfering septa based on its orientation is presented along with its relationship to the prevalence and severity of sinus membrane perforations. Additionally, the impact of membrane perforation on post-operative complications and marginal bone loss during the first year of loading is evaluated. MATERIALS & METHODS: Retrospective chart review of 79 consecutive sinus lift procedures with lateral window technique and 107 implants...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28442758/an-amidase_3-domain-containing-n-acetylmuramyl-l-alanine-amidase-is-required-for-mycobacterial-cell-division
#13
Sibusiso Senzani, Dong Li, Ashima Bhaskar, Christopher Ealand, James Chang, Binayak Rimal, Chengyin Liu, Sung Joon Kim, Neeraj Dhar, Bavesh Kana
Mycobacteria possess a multi-layered cell wall that requires extensive remodelling during cell division. We investigated the role of an amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme implicated in cell division. We demonstrated that deletion of MSMEG_6281 (Ami1) in Mycobacterium smegmatis resulted in the formation of cellular chains, illustrative of cells that were unable to complete division. Suprisingly, viability in the Δami1 mutant was maintained through atypical lateral branching, the products of which proceeded to form viable daughter cells...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435129/laparoscopic-sacral-colpopexy-the-%C3%A2-6points-%C3%A2-technique
#14
Marie Schaub, Lise Lecointre, Emilie Faller, Thomas Boisramé, Jean-Jacques Baldauf, Arnaud Wattiez, Cherif Youssef Akladios
STUDY OBJECTIVE: Illustrate laparoscopic sacral colpopexy for pelvic organ prolapse, a new method using a simplified mesh fixation technique, with only six fixation points DESIGN: A step-by-step explanation of the surgery using video (educative video) The video was approved by the local IRB. SETTING: University Hospital of Strasbourg, France. PATIENTS: Women with multicompartment prolapse INTERVENTION: First, we dissect the promontorium, and vertically incise the posterior parietal peritoneum on the right pelvic sidewall until the pouch of Douglas...
April 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28433648/repeated-threat-without-direct-harm-alters-metabolic-capacity-in-select-regions-that-drive-defensive-behavior
#15
D J Kim, A S Lee, A A Yttredahl, R Gómez-Rodríguez, B J Anderson
To understand the behavioral consequences of intermittent anticipatory stress resulting from threats without accompanying physiological challenges, we developed a semi-naturalistic rodent housing and foraging environment that can include threats that are unpredictable in timing. Behavior is automatically recorded while rats forage for food or water. Over three weeks, the threats have been shown to elicit risk assessment behaviors, increase defensive burying and increase adrenal gland weight. To identify brain regions activated by this manipulation, we measured cytochrome c oxidase (COX), which is tightly coupled to neural activity...
April 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28432416/commentary-on-3d-photogrammetric-analysis-of-the-nasal-tip-projection-and-derotation-based-on-the-nasal-tip-quadripod-concept
#16
Cerkes Nazım
Asian noses are mainly characterized by a low nasal dorsum, a short nose and an underprojected nasal tip due to underdeveloped (short and weak) alar cartilages. The goals of the surgery are to increase the tip projection, elongate the nose and augment the dorsum. In Asian noses the structural approach helps strengthen the weak cartilages and add definition to the nasal tip. There are various methods to increase tip projection and definition. Columellar strut, caudal septal extension graft, tip grafts and lateral crural grafts in order to elongate the upper legs of the nasal tip tripod can be used...
April 21, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28414682/a-left-main-coronary-artery-thrombus-presenting-as-a-non-st-elevation-mi
#17
U Ezema, D Daberkow, T Delord, L Guidry, N R Sells
INTRODUCTION: Left main coronary artery (LMCA); thrombus with an acute myocardial infarction identified with coronary angiography is a clinically rare condition with an extremely high mortality rate. We present a case of LMCA thrombus that presented as a non-ST elevation myocardial infarction (NSTEMI);. CASE: A 45-year-old woman with a history of tobacco use and hyperlipidemia presented with a complaint of 10/10 "hard pain" across her chest radiating to her left shoulder and breast which woke her from sleep...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413542/lateral-ventricular-gliosarcoma-with-attachment-to-septum-pellucidum
#18
Pravin Salunke, Harnarayan Singh, Kim Vaiphei
Gliosarcomas are lesions with both glial and sarcomatous elements and are usually seen abutting the dura. Intraventricular location is extremely rare. Such an unusual intraventricular gliosarcoma is being reported.
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28410632/evolution-of-left-ventricular-size-in-late-survivors-of-surgery-for-hypoplastic-left-heart-syndrome
#19
Markus Bjurbom, Ajay J Iyengar, Florian Moenkemeyer, Igor E Konstantinov, Christian P Brizard, Yves d'Udekem
BACKGROUND: Aortic atresia and mitral atresia are predictors of adverse events in early life in patients with hypoplastic left heart syndrome, but it is unclear whether late outcomes are also affected, and whether this impact is related to a small hypertrophied left ventricle (LV) that impairs right ventricle (RV) function. METHODS: Thirty patients with hypoplastic left heart syndrome surviving with a Fontan procedure were identified. Follow-up echocardiograms were available at birth, before the Fontan procedure, and several years after...
April 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28407252/combined-endonasal-and-eyelid-approach-for-management-of-extensive-frontal-sinus-inverting-papilloma
#20
Monirah Albathi, Murugappan Ramanathan, Andrew P Lane, Kofi D O Boahene
OBJECTIVES: Sinonasal inverting papilloma (IP) is a benign but locally aggressive mucosal neoplasm with a high recurrence rate. Extension into the frontal sinus presents surgical challenges for endonasal resection. This study presents an orbitofrontal approach for managing extensive IP. STUDY DESIGN: Case series. METHODS: Four patients seen between 2012 and 2016 with biopsy-proven IP with lateral frontal sinus extension underwent a combined endonasal and transpalpebral approach for tumor resection...
April 13, 2017: Laryngoscope
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