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https://www.readbyqxmd.com/read/28442758/an-amidase_3-domain-containing-n-acetylmuramyl-l-alanine-amidase-is-required-for-mycobacterial-cell-division
#1
Sibusiso Senzani, Dong Li, Ashima Bhaskar, Christopher Ealand, James Chang, Binayak Rimal, Chengyin Liu, Sung Joon Kim, Neeraj Dhar, Bavesh Kana
Mycobacteria possess a multi-layered cell wall that requires extensive remodelling during cell division. We investigated the role of an amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme implicated in cell division. We demonstrated that deletion of MSMEG_6281 (Ami1) in Mycobacterium smegmatis resulted in the formation of cellular chains, illustrative of cells that were unable to complete division. Suprisingly, viability in the Δami1 mutant was maintained through atypical lateral branching, the products of which proceeded to form viable daughter cells...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435129/laparoscopic-sacral-colpopexy-the-%C3%A2-6points-%C3%A2-technique
#2
Marie Schaub Resident, Lise Lecointre, Emilie Faller, Thomas Boisramé, Jean-Jacques Baldauf, Arnaud Wattiez, Cherif Youssef Akladios
STUDY OBJECTIVE: Illustrate laparoscopic sacral colpopexy for pelvic organ prolapse, a new method using a simplified mesh fixation technique, with only six fixation points DESIGN: A step-by-step explanation of the surgery using video (educative video) The video was approved by the local IRB. SETTING: University Hospital of Strasbourg, France. PATIENTS: Women with multicompartment prolapse INTERVENTION: First, we dissect the promontorium, and vertically incise the posterior parietal peritoneum on the right pelvic sidewall until the pouch of Douglas...
April 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28433648/repeated-threat-without-direct-harm-alters-metabolic-capacity-in-select-regions-that-drive-defensive-behavior
#3
D J Kim, A S Lee, A A Yttredahl, R Gómez-Rodríguez, B J Anderson
To understand the behavioral consequences of intermittent anticipatory stress resulting from threats without accompanying physiological challenges, we developed a semi-naturalistic rodent housing and foraging environment that can include threats that are unpredictable in timing. Behavior is automatically recorded while rats forage for food or water. Over three weeks, the threats have been shown to elicit risk assessment behaviors, increase defensive burying and increase adrenal gland weight. To identify brain regions activated by this manipulation, we measured cytochrome c oxidase (COX), which is tightly coupled to neural activity...
April 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28432416/commentary-on-3d-photogrammetric-analysis-of-the-nasal-tip-projection-and-derotation-based-on-the-nasal-tip-quadripod-concept
#4
Cerkes Nazım
Asian noses are mainly characterized by a low nasal dorsum, a short nose and an underprojected nasal tip due to underdeveloped (short and weak) alar cartilages. The goals of the surgery are to increase the tip projection, elongate the nose and augment the dorsum. In Asian noses the structural approach helps strengthen the weak cartilages and add definition to the nasal tip. There are various methods to increase tip projection and definition. Columellar strut, caudal septal extension graft, tip grafts and lateral crural grafts in order to elongate the upper legs of the nasal tip tripod can be used...
April 21, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28414682/a-left-main-coronary-artery-thrombus-presenting-as-a-non-st-elevation-mi
#5
U Ezema, D Daberkow, T Delord, L Guidry, N R Sells
INTRODUCTION: Left main coronary artery (LMCA); thrombus with an acute myocardial infarction identified with coronary angiography is a clinically rare condition with an extremely high mortality rate. We present a case of LMCA thrombus that presented as a non-ST elevation myocardial infarction (NSTEMI);. CASE: A 45-year-old woman with a history of tobacco use and hyperlipidemia presented with a complaint of 10/10 "hard pain" across her chest radiating to her left shoulder and breast which woke her from sleep...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413542/lateral-ventricular-gliosarcoma-with-attachment-to-septum-pellucidum
#6
Pravin Salunke, Harnarayan Singh, Kim Vaiphei
Gliosarcomas are lesions with both glial and sarcomatous elements and are usually seen abutting the dura. Intraventricular location is extremely rare. Such an unusual intraventricular gliosarcoma is being reported.
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28410632/evolution-of-left-ventricular-size-in-late-survivors-of-surgery-for-hypoplastic-left-heart-syndrome
#7
Markus Bjurbom, Ajay J Iyengar, Florian Moenkemeyer, Igor E Konstantinov, Christian P Brizard, Yves d'Udekem
BACKGROUND: Aortic atresia and mitral atresia are predictors of adverse events in early life in patients with hypoplastic left heart syndrome, but it is unclear whether late outcomes are also affected, and whether this impact is related to a small hypertrophied left ventricle (LV) that impairs right ventricle (RV) function. METHODS: Thirty patients with hypoplastic left heart syndrome surviving with a Fontan procedure were identified. Follow-up echocardiograms were available at birth, before the Fontan procedure, and several years after...
April 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28407252/combined-endonasal-and-eyelid-approach-for-management-of-extensive-frontal-sinus-inverting-papilloma
#8
Monirah Albathi, Murugappan Ramanathan, Andrew P Lane, Kofi D O Boahene
OBJECTIVES: Sinonasal inverting papilloma (IP) is a benign but locally aggressive mucosal neoplasm with a high recurrence rate. Extension into the frontal sinus presents surgical challenges for endonasal resection. This study presents an orbitofrontal approach for managing extensive IP. STUDY DESIGN: Case series. METHODS: Four patients seen between 2012 and 2016 with biopsy-proven IP with lateral frontal sinus extension underwent a combined endonasal and transpalpebral approach for tumor resection...
April 13, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28401248/-nasal-turbinate-surgery
#9
F Sommer, J Lindemann, M-O Scheithauer, T K Hoffmann, J A Veit
The nose forms the first 8 cm of the upper respiratory tract and is responsible for cleansing, humidification, and temperature control of the supplied air. This is also referred to as conditioning. The nasal valve region, formed by the head of the lower nasal concha, portions of the cartilaginous septum, and the upper lateral cartilage, is responsible for diffusing and accelerating the respiratory airflow. Prerequisite are regular mucociliary clearance and sufficient air passage. Hypertrophy of the lower nasal turbinate is one of the most common causes of symptomatic nasal congestion...
April 11, 2017: HNO
https://www.readbyqxmd.com/read/28391991/relation-of-qrs-duration-to-response-to-cardiac-resynchronization-therapy-in-patients-with-left-bundle-branch-block
#10
Biagio Sassone, Matteo Bertini, Matteo Beltrami, Michele Malagù, Giovanni Pasanisi, Helene Afi Kuwornu, Nicola Avigni, Giuseppe Fucà, Federico Pacchioni, Monica Minarelli, Maria Letizia Bacchi Reggiani, Luigi Padeletti
Left ventricular (LV) dyssynchrony (LVdys) is a necessary condition for successful cardiac resynchronization therapy (CRT). Despite left bundle branch block (LBBB) representing a reliable surrogate of LVdys, not all LBBB patients will respond to CRT. Our aim was to investigate the relation between QRS duration and LVdys in patients with LBBB who underwent CRT. We retrospectively studied 165 patients with LBBB who underwent CRT implantation according to the current guidelines. A 6-month reduction of LV end-systolic volume ≥15% identified responders to CRT...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28388792/midvault-reconstruction-in-primary-rhinoplasty
#11
Shannon Rudy, Sami P Moubayed, Sam P Most
The nasal midvault is an important consideration in rhinoplasty. This region is defined by the attachment of the upper lateral cartilages (ULCs) to the nasal bones superiorly and the cartilaginous septum medially. Inadequate management of the nasal midvault can have negative functional and aesthetic ramifications. Indications for midvault reconstruction in primary rhinoplasty include a narrow midvault, dorsal hump resection, a deviated midvault, and an asymmetric midvault, with an additional relative indication of zone 1 lateral wall insufficiency (LWI), defined as dynamic collapse of a weakened lateral nasal wall at the level of the ULC...
April 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28388635/the-bhlh-transcription-factor-spatula-enables-cytokinin-signaling-and-both-activate-auxin-biosynthesis-and-transport-genes-at-the-medial-domain-of-the-gynoecium
#12
J Irepan Reyes-Olalde, Víctor M Zúñiga-Mayo, Joanna Serwatowska, Ricardo A Chavez Montes, Paulina Lozano-Sotomayor, Humberto Herrera-Ubaldo, Karla L Gonzalez-Aguilera, Patricia Ballester, Juan José Ripoll, Ignacio Ezquer, Dario Paolo, Alexander Heyl, Lucia Colombo, Martin F Yanofsky, Cristina Ferrandiz, Nayelli Marsch-Martínez, Stefan de Folter
Fruits and seeds are the major food source on earth. Both derive from the gynoecium and, therefore, it is crucial to understand the mechanisms that guide the development of this organ of angiosperm species. In Arabidopsis, the gynoecium is composed of two congenitally fused carpels, where two domains: medial and lateral, can be distinguished. The medial domain includes the carpel margin meristem (CMM) that is key for the production of the internal tissues involved in fertilization, such as septum, ovules, and transmitting tract...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28378375/dopaminergic-activation-anticipates-daily-nursing-in-the-rabbit
#13
J Aguirre, E Meza, M Caba
Maternal care is a motivated behavior and in the rabbit it is restricted to the spontaneous return of the mother to nurse her pups for just a few minutes once a day. Previously we have reported neural activation of brain areas and neuroendocrine cells after nursing. However, this daily spontaneous return suggests that the mother is in a high motivational state to nurse her pups. Here we hypothesized that during anticipation of nursing there is an activation of dopaminergic neurons of the mesolimbic system and in their target areas...
April 4, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28375615/specific-connectivity-and-unique-molecular-identity-of-met-receptor-tyrosine-kinase-expressing-serotonergic-neurons-in-the-caudal-dorsal-raphe-nuclei
#14
Ryan J Kast, Hsiao-Huei Wu, Piper Williams, Patricia Gaspar, Pat Levitt
Molecular characterization of neurons across brain regions has revealed new taxonomies for understanding functional diversity even among classically defined neuronal populations. Neuronal diversity has become evident within the brain serotonin (5-HT) system, which is far more complex than previously appreciated. However, until now it has been difficult to define subpopulations of 5-HT neurons based on molecular phenotypes. We demonstrate that the MET receptor tyrosine kinase (MET) is specifically expressed in a subset of 5-HT neurons within the caudal part of the dorsal raphe nuclei (DRC) that is encompassed by the classic B6 serotonin cell group...
April 4, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28373627/effects-of-transplanted-human-cord-blood-mononuclear-cells-on-pulmonary-hypertension-in-immunodeficient-mice-and-their-distribution
#15
Mikio Sugano, Homare Yoshida, Hirotsugu Kurobe, Hiroki Arase, Hajime Kinoshita, Takashi Kitaichi, Noriko Sugasawa, Soichiro Nakayama, Kazuhisa Maeda, Minoru Irahara, Tetsuya Kitagawa
OBJECTIVES: To investigate the effects of human umbilical cord blood-derived mononuclear cell (hUCB-MNC) transplantation on pulmonary hypertension (PH) induced by monocrotaline (MCT) in immunodeficient mice and their distribution. METHODS: MCT was administered to BALB/c Slc-nu/nu mice, and PH was induced in mice 4 weeks later. Fresh hUCB-MNCs harvested from a human donor after her delivery were injected intravenously into those PH mice. The medial thickness of pulmonary arterioles, ratio of right ventricular to septum plus left ventricular weight (RV/S+LV), and ratio of acceleration time to ejection time of pulmonary blood flow waveform (AT/ET) were determined 4 weeks after hUCB-MNC transplantation...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28372859/the-wedge-sign-an-imaging-sign-for-aggressive-lacrimal-gland-disease
#16
Daniele Lorenzano, Geoffrey E Rose
PURPOSE: Lacrimal gland carcinoma can form a triangle of tissue back to the orbital apex, intraconal spread apparently being prevented by the intermuscular septum. The "wedge sign" frequency is assessed in lacrimal carcinoma, lacrimal lymphoma, or dacryoadenitis. DESIGN: Retrospective masked review of images from patients with biopsy-proven lacrimal gland pathology. METHODS: For each patient, the presence of a triangle of tissue between the lateral rectus and lateral orbital wall and the superior rectus and the orbital roof was assessed by masked review of computed tomography or magnetic resonance imaging...
March 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28357724/correlation-between-right-ventricular-t1-mapping-and-right-ventricular-dysfunction-in-non-ischemic-cardiomyopathy
#17
Christine L Jellis, Teerapat Yingchoncharoen, Neville Gai, Kenya Kusunose, Zoran B Popović, Scott Flamm, Deborah Kwon
Right ventricular (RV) fibrosis is increasingly recognized as the underlying pathological substrate in a variety of clinical conditions. We sought to employ cardiac magnetic resonance (CMR) techniques of strain imaging and longitudinal relaxation time (T1) mapping to better examine the relationship between RV function and structure. Our aim was to initially evaluate the feasibility of these techniques to evaluate the right ventricle. We then sought to explore the relationship between RV function and underlying fibrosis, along with examining the evolution of RV remodeling according to the amount of baseline fibrosis...
March 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28353299/an-unusual-case-of-accessory-head-of-coracobrachialis-muscle-involving-lateral-cord-of-brachial-plexus-and-its-clinical-significance
#18
Silvio Antonio Garbelotti, Sérgio Ricardo Marques, Paulo Ricardo Rocha, Valdemir Rodrigues Pereira, Luis Otavio Carvalho de Moraes
Knowledge of anatomical variations in the peripheral nervous system is key in the interpretation of unusual clinical signs or during physical or diagnostic imaging. This case study is a description of an anatomical variation between the coracobrachialis muscle and brachial plexus. In a routine dissection in the human anatomy laboratory, we were faced with an anatomical variation in the coracobrachialis muscle, observed in the upper right limb of a male cadaver. The coracobrachialis muscle had a common origin at the apex of the coracoid process and then divided into two heads...
March 29, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28352598/a-new-septum-in-the-female-breast
#19
Mostafa Abdel Rahman Awad, Mahmoud Magdi Sherif, Eaman Yahya Sadek, Hesham Aly Helal, Wafaa Raafat Abdel Hamid
BACKGROUND: Understanding the female breast fascial system is of paramount importance in breast surgery. Little was written about breast ligaments. Most articles refer to Cooper's work without further anatomical studies. Lately, a horizontal septum has been described conveying nerves and vessels to the nipple areola complex. METHODS: During the surgical dissection of the lower part of the breast, in supero-medial technique for breast reduction operations, a fascial septum between the lower two quadrants was detected...
March 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28343558/simulator-based-obstetric-ultrasound-training-a-prospective-randomized-single-blinded-study
#20
Hadar Rosen, Rory Windrim, Yee Man Lee, Lara Gotha, Vsevolod Perelman, Stefania Ronzoni
OBJECTIVE: To compare the use of simulator-based and patient-based obstetric ultrasound training. METHODS: This was a prospective, randomized, single-blinded trial. Eighteen consenting obstetric trainees with minimal previous ultrasound exposure were recruited. Enrolled patients were also fully consenting. Mid-trimester fetal brain anatomy in the standard planes (i.e., biparietal diameter and head circumference, cavum septum pellucidum, posterior fossa, and lateral ventricle) was chosen as a surrogate for all fetal anatomy ultrasound training...
March 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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