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https://www.readbyqxmd.com/read/28926609/developmental-expression-of-membrane-type-4-matrix-metalloproteinase-mt4-mmp-mmp17-in-the-mouse-embryo
#1
María José Blanco, Iván Rodríguez-Martín, Ana I R Learte, Cristina Clemente, María Gregoria Montalvo, Motoharu Seiki, Alicia G Arroyo, Cristina Sánchez-Camacho
Matrix metalloproteinases (MMPs) constitute a large group of endoproteases that play important functions during embryonic development, tumor metastasis and angiogenesis by degrading components of the extracellular matrix. Within this family, we focused our study on Mt4-mmp (also called Mmp17) that belongs to a distinct subset that is anchored to the cell surface via a glycosylphosphatidylinositol (GPI) moiety and with the catalytic site exposed to the extracellular space. Information about its function and substrates is very limited to date, and little has been reported on its role in the developing embryo...
2017: PloS One
https://www.readbyqxmd.com/read/28915203/treatment-of-zenker-s-diverticulum-with-endoscopic-stapled-esophago-divertisculostomy-esd-analysis-of-long-term-outcome
#2
Michele Mazza, Alberto N Bergamini, Paolo Parise, Andrea Cossu, Olga Adamenko, Ugo Elmore, Riccardo Rosati
BACKGROUND: Endoscopic Zenker diverticulum (ZD) treatment has become quite common because of the low complication rates, reduced procedure time, and shorter hospital stay. Many endoscopic treatments are available including the endoscopic stapled esophago-diverticulostomy (ESD). Many data regarding ESD are available on the short-term outcomes, but few on the long-term ones. MATERIALS AND METHODS: From March 1998 to July 2016, 126 patients with ZD were candidate for ESD...
September 14, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28912039/acquired-heart-disease-superimposed-on-congenital-heart-disease
#3
D Luke Glancy
A 50-year-old man with a murmur since birth developed systemic arterial hypertension as an adult. He came to the hospital because of dyspnea. He had a pulmonic valve ejection click and a murmur of pulmonic stenosis. His echocardiogram showed biventricular hypertrophy, a flat ventricular septum, a D-shaped left ventricle, systolic doming of the pulmonic valve, and Doppler evidence of a 70 mm Hg peak systolic pressure gradient across the pulmonic valve and a peak right ventricular systolic pressure of 100 mm Hg...
August 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28887226/reconciling-the-different-faces-of-hippocampal-theta-the-role-of-theta-oscillations-in-cognitive-emotional-and-innate-behaviors
#4
REVIEW
Tatiana Korotkova, Alexey Ponomarenko, Caitlin K Monaghan, Steven L Poulter, Francesca Cacucci, Tom Wills, Michael E Hasselmo, Colin Lever
The theta oscillation (5-10Hz) is a prominent behavior-specific brain rhythm. This review summarizes studies showing the multifaceted role of theta rhythm in cognitive functions, including spatial coding, time coding and memory, exploratory locomotion and anxiety-related behaviors. We describe how activity of hippocampal theta rhythm generators - medial septum, nucleus incertus and entorhinal cortex, links theta with specific behaviors. We review evidence for functions of the theta-rhythmic signaling to subcortical targets, including lateral septum...
September 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28882491/anatomic-and-high-resolution-computed-tomographic-angiography-study-of-the-lateral-femoral-condyle-flap-implications-for-surgical-dissection
#5
Mohamed Morsy, Yoo Joon Sur, Osman Akdag, Amr Eisa, Tarek A El-Gammal, Nirusha Lachman, Steven L Moran
BACKGROUND: The lateral femoral condyle (LFC) flap is a vascularized bone flap based on the superior lateral genicular artery (SLGA). Harvest technique for this flap has not yet been demonstrated. The purpose of this study was to better delineate the blood supply to the bone and skin of this flap to allow for a safe and effective harvest. MATERIALS AND METHODS: Twenty-three lower extremities were injected with latex or a mixture of latex and barium sulfate. The SLGA was identified and dissected, documenting the course, diameter, anatomical relations, length, and branches...
August 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28871491/robust-age-but-limited-sex-differences-in-mu-opioid-receptors-in-the-rat-brain-relevance-for-reward-and-drug-seeking-behaviors-in-juveniles
#6
Caroline J W Smith, Aarane M Ratnaseelan, Alexa H Veenema
In the brain, the µ-opioid receptor (MOR) is involved in reward-seeking behaviors and plays a pivotal role in the mediation of opioid use disorders. Furthermore, reward-seeking behaviors and susceptibility to opioid addiction are particularly evident during the juvenile period, with a higher incidence of opioid use in males and higher sensitivity to opioids in females. Despite these age and sex differences in MOR-mediated behaviors, little is known regarding potential age and sex differences in the expression of MORs in the brain...
September 4, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28871239/arginine-vasopressin-effects-on-subjective-judgments-and-neural-responses-to-same-and-other-sex-faces-in-men-and-women
#7
James K Rilling, Ting Li, Xiangchuan Chen, Pritam Gautam, Ebrahim Haroon, Richmond R Thompson
Arginine vasopressin (AVP) influences social and emotional behaviors across a wide range of species. In humans, intranasal AVP has been previously shown to alter physiological responses to and subjective judgments of same-sex faces in both men and women. The present study attempted to elucidate the neural mechanism for these effects by randomizing 40 healthy men and 40 healthy women to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 min before imaging their brain function with fMRI as they viewed same and other-sex faces...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28868605/development-of-digastric-muscles-in-human-fetuses-a-review-and-findings-in-the-flexor-digitorum-superficialis-muscle
#8
José Francisco Rodríguez-Vázquez, Zhe Wu Jin, Peng Zhao, Gen Murakami, Xiang Wu Li, Yu Jin
The digastricus and omohyoideus muscles are digastric muscles with two muscle bellies. An insertion tendon of the posterior belly becomes an intermediate tendon in digastricus muscles, whereas a single band-like muscle in omohyoideus muscles may later be interrupted by an intermediate tendon, possibly due to muscle cell death caused by mechanical stress. In human fetuses, an intermediate tendon provides the temporal origins of the tensor veli palatini and tensor tympani muscles. Some reptiles, including snakes, carry multiple series of digastric-like axial muscles, in which each intersegmental septum is likely to become an intermediate tendon...
September 4, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28866684/functional-connectivity-pattern-of-the-internal-hippocampal-network-in-awake-pigeons-a-resting-state-fmri-study
#9
Mehdi Behroozi, Felix Ströckens, Martin Stacho, Onur Güntürkün
In the last two decades, the avian hippocampus has been repeatedly studied with respect to its architecture, neurochemistry, and connectivity pattern. We review these insights and conclude that we unfortunately still lack proper knowledge on the interaction between the different hippocampal subregions. To fill this gap, we need information on the functional connectivity pattern of the hippocampal network. These data could complement our structural connectivity knowledge. To this end, we conducted a resting-state fMRI experiment in awake pigeons in a 7-T MR scanner...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28863206/periorbital-ecchymoses-and-breathlessness
#10
Sudip Kumar Ghosh, Biswajit Majumder, Sandip Ghosh, Dilip Kumar Das, Sharmistha Chatterjee
A 54-year-old man presented at our facility with a 3-month history of exertional breathlessness and purple blotches around his eyes. Examination revealed bilateral periorbital and perioral ecchymosis, purpuric spots along his waist, and waxy papules on his eyelids. In addition, the patient had macroglossia with nodular infiltration and irregular indentations at the lateral margin of his tongue. The patient also had a raised jugular venous pressure and prominent atrial and ventricular waves. Further examination revealed a fourth heart sound over the left ventricular apex, as well as bilateral basal rales...
September 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28860907/endoscopic-intranasal-findings-in-unilateral-primary-acquired-nasolacrimal-duct-obstruction
#11
Swati Singh, Mohammad Shahid Alam, Mohammad Javed Ali, Milind N Naik
PURPOSE: To evaluate intranasal endoscopic findings in patients with unilateral primary acquired nasolacrimal duct obstruction and compare them with the normal cohort. METHODS: A prospective case-control study with 50 unilateral primary acquired nasolacrimal duct obstruction (PANDO) and 50 healthy controls. All patients were evaluated by endoscopic nasal examination for the presence of deviated nasal septum (DNS), type of deviation (bony or cartilaginous), side of deviation, septal spurs, caudal dislocation, any turbinate hypertrophy and endoscopic features suggestive of sinusitis...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28857999/transnasal-endoscopic-resection-of-a-pleomorphic-adenoma-originate-from-nasal-floor
#12
Yesun Cho, Yul Gyun Kim, Eunhye Shin, Boo-Young Kim
A 81-year-old female presented to our hospital frequent epistaxis. Nasal endoscopy showed a mass obstructing nasal cavity completely and occupying middle meatus. Magnetic resonance imaging was performed, an about 4.8 × 4 × 4.2 cm sized heterogeneous T2 high signal intensity and T1 enhancing mass mainly involving right nasal cavity with invasion of right hard palate with bony destruction. Therefore, the authors planned to do endoscopic mass excision, under general anesthesia for diagnosis and treatment...
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28857984/levator-aponeurosis-and-muller-muscle-plication-reinforced-with-levator-sheath-advancement-for-blepharoptosis-correction
#13
Jin Suk Byun, Kun Hwang, Sang Yun Lee, Hak Tae Kim, Kenneth Kim
The authors innovated the levator aponeurosis and Muller muscle plication reinforced with levator sheath advancement (AMPSA) for blepharoptosis correction. The orbital septum was opened 1 mm above its fusion with the levator aponeurosis. The preaponeurotic fat was retracted and the thickened part of the levator sheath was identified. Two plication sutures were made: medial suture at the medial border of the pupil and lateral between the lateral border of the pupil and the lateral limbus. A needle with 6-0 nylon thread first bit the tarsal plate approximately 1 mm below its upper border, then bit the levator aponeurosis and the Muller muscle together at 3 to 6 mm above the upper border of the tarsal plate...
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28837679/influence-of-coronary-architecture-on-the-variability-in-myocardial-infarction-induced-by-coronary-ligation-in-rats
#14
Satoshi Kainuma, Shigeru Miyagawa, Satsuki Fukushima, Hirotsugu Tsuchimochi, Takashi Sonobe, Yutaka Fujii, James T Pearson, Atsuhiro Saito, Akima Harada, Koichi Toda, Mikiyasu Shirai, Yoshiki Sawa
It has been shown that the size of myocardial infarction in rats created by coronary ligation technique is not uniform, varying from 4% to 65%. We hypothesized that infarct size variability induced by coronary artery ligation might be caused by coronary artery branching pattern. Coronary artery angiography was performed in 50 normal Lewis rats and in chronic myocardial infarction models in which coronary artery was ligated immediately below the left atrial appendage or 2mm distal to the left atrial appendage (n = 25 for each), followed by histological analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28833432/elasticity-of-ascending-aorta-and-left-ventricular-myocardial-functions-in-children-with-bicuspid-aortic-valve
#15
Filiz Ekici, Diyar Uslu, Selen Bozkurt
BACKGROUND: The aim of the study was to determine the aortic elasticity parameters (EPs) and myocardial function in children with bicuspid aortic valve (BAV). Additionally, we evaluated the effect of aortic leaflet phenotype (ALP) and aortic dilatation on elasticity parameters. METHODS: Sixty-two children diagnosed with isolated BAV (mean age 9.3 years old; patient group) and 63 healthy children (control group) have been evaluated for this study. Patient group was divided into three age subgroups: between 0-6, 7-11 and 12-17 age intervals...
August 22, 2017: Echocardiography
https://www.readbyqxmd.com/read/28820836/the-surgeon-s-fist-with-the-thumb-up-to-guide-the-design-and-inset-of-the-osteoseptocutaneous-fibula-flap-in-mandibular-reconstruction
#16
Nidal F Al Deek, Chung-Kan Tsao, Fu-Chan Wei
Successful reconstruction of the oromandibular defect with the osteoseptocutaneous fibula flap necessitates flawless design and inset, an experience-demanding endeavor. Laterality of the fibula flap has been thought to pose a certain challenge to the reconstruction. To address this concern and guide flap design and inset, the authors propsed using the surgeon's fist with the thumb up to replicate key anatomic land marks of the fibula flap: the peroneal vessels and proximal bone end, the posterior crural septum including the septal vessels, the skin, and the lateral surface of the fibula bone...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28814342/septal-contributions-to-olfactory-bulb-interneuron-diversity-in-the-embryonic-mouse-telencephalon-role-of-the-homeobox-gene-gsx2
#17
Shenyue Qin, Stephanie M Ware, Ronald R Waclaw, Kenneth Campbell
BACKGROUND: Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminence (dLGE) and septum. These cells migrate rostrally toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer glomerular layer (GL). Although previous studies have attempted to investigate regional contributions to OB interneuron diversity, few genetic tools have been used to address this question at embryonic time points when the earliest populations are specified...
August 16, 2017: Neural Development
https://www.readbyqxmd.com/read/28801203/echocardiographic-prediction-of-cardiac-resynchronization-therapy-response-requires-analysis-of-both-mechanical-dyssynchrony-and-right-ventricular-function-a-combined-analysis-of%C3%A2-patient-data-and-computer-simulations
#18
Wouter M van Everdingen, John Walmsley, Maarten J Cramer, Iris van Hagen, Bart W L De Boeck, Mathias Meine, Tammo Delhaas, Pieter A Doevendans, Frits W Prinzen, Joost Lumens, Geert E Leenders
BACKGROUND: Pronounced echocardiographically measured mechanical dyssynchrony is a positive predictor of response to cardiac resynchronization therapy (CRT), whereas right ventricular (RV) dysfunction is a negative predictor. The aim of this study was to investigate how RV dysfunction influences the association between mechanical dyssynchrony and left ventricular (LV) volumetric remodeling following CRT. METHODS: One hundred twenty-two CRT candidates (mean LV ejection fraction, 19 ± 6%; mean QRS width, 168 ± 21 msec) were prospectively enrolled and underwent echocardiography before and 6 months after CRT...
August 8, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28775060/measurement-for-detection-of-incomplete-partition-type-ii-anomalies-on-mr-imaging
#19
K L Reinshagen, H D Curtin, A M Quesnel, A F Juliano
BACKGROUND AND PURPOSE: Incomplete partition type II of the cochlea, commonly coexisting with an enlarged vestibular aqueduct, can be a challenging diagnosis on MR imaging due to the presence of a dysplastic spiral lamina-basilar membrane neural complex, which can resemble the normal interscalar septum. The purpose of this study was to determine a reproducible, quantitative cochlear measurement to assess incomplete partition type II anomalies in patients with enlarged vestibular aqueducts using normal-hearing ears as a control population...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28770434/assessment-of-the-septal-area-neuronal-activity-during-penile-erections-in-rapid-eye-movement-sleep-and-waking-in-the-rats
#20
Kamalesh K Gulia, Yukihiko Kayama, Yoshimasa Koyama
To understand the central mechanism of penile erections during rapid eye movement (REM) sleep and waking, single units were recorded from the septal area in un-anesthetized head-restrained rats simultaneous with erections. Erectile events were assessed by pressure in the bulb of the corpus spongiosum of the penis and bulbospongiosus-muscle activity. Of 143 recorded neurons, 36% showed increased activity (E-type) and 24% decreased activity (I-type) during different phases of erection in REM sleep, while 10% were E-type and 35% were I-type during erections in waking...
August 2, 2017: Journal of Physiological Sciences: JPS
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