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https://www.readbyqxmd.com/read/29166332/testicular-estrogen-secreting-leydig-cell-tumor-in-18f-fdg-pet-ct-an-incidental-detection-in-a-patient-treated-by-chemotherapy-for-hodgkin-lymphoma
#1
Axel Van Der Gucht, Zaher Maged, Rodolfo Burruni, Jean-Luc Barras, Niklaus Schaefer
We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy. The serum estradiol level was abnormally elevated reflecting the estrogen-secreting profile. This report highlights that a focal F-FDG uptake in the testicular region with unexplained gynecomastia should suggest the diagnosis of an estrogen-secreting Leydig cell tumor on F-FDG PET/CT...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29165804/intrahepatic-congenital-portosystemic-shunts-in-dogs-short-and-long-term-outcome-of-suture-attenuation
#2
M S Tivers, V J Lipscomb, P Bristow, D J Brockman
OBJECTIVES: To report the short- and long-term outcomes of one- or two-staged suture attenuation for complete closure of intrahepatic congenital portosystemic shunts in dogs. MATERIALS AND METHODS: Retrospective cohort study of dogs surgically treated for intrahepatic congenital portosystemic shunts between February 2000 and March 2015. Long-term follow-up was conducted by telephone conversations with the referring veterinary surgeon, owner, or both. RESULTS: In total, 55 dogs had suture attenuation of their intrahepatic congenital portosystemic shunt; 10 dogs (18·2%) tolerated complete attenuation, whilst 45 dogs (81·8%) tolerated partial attenuation...
November 22, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29164767/the-association-between-steatosis-and-diabetes-with-hepatocellular-carcinoma-in-non-genotype-3-chronic-hepatitis-c-patients
#3
Yi-Hao Yen, Ming-Tsung Lin, Fang-Ying Kuo, Kuo-Chin Chang, Ming-Chao Tsai, Po-Lin Tseng, Cheng-Kun Wu, Jung-Ting Lin, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen
BACKGROUND AND AIMS: Diabetes mellitus (DM) has been found to be strongly associated with an increased risk of hepatocellular carcinoma (HCC) among chronic hepatitis C (CHC) patients. Several studies have also found an association between metabolic steatosis and the risk of HCC in CHC patients, whether this latter association has been accounted for by the known relationship between DM and HCC is still unknown. METHODS: A cohort consisting of 976 non-genotype 3 patients histologically proven to have CHC and treated with interferon and ribavirin was studied...
November 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29164563/melatonin-regulates-traumatic-optic-neuropathy-via-targeting-autophagy
#4
J Wei, L-S Ma, D-J Liu, J Guo, W-K Jiang, H-J Yu
OBJECTIVE: Traumatic optic neuropathy (TON) usually refers to the indirect damage to the optical nerve, which can cause partial or complete blindness. Melatonin (MT) is a kind of indole hormone, and the retina is one of its natural sites of secretion in the human body. This study aims to explore MT in the retina and optic nerve injuries due to TON. MATERIALS AND METHODS: Sprague-Dawley (SD) rats were used for TON model in the study. After operation, rats were treated with MT or phosphate buffered saline (PBS) for 4, 7, 14, 21, and 28 days before sacrifice...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164554/-the-experience-of-caring-for-a-child-suffering-from-incontinent-dermatitis
#5
Hong-Ru Lu, Yung-Ju Chen, Ya-Fang Ko
This paper describes the experience of caring for a child with incontinent dermatitis that was caused by improper family care. From March 27, 2015 to April 2, 2015, the authors used Gordon's 11 functional health parameters to collect subjective and objective data on the physical, mental and social conditions of the care recipient. To understand the nursing-related problems, including impaired skin integrity, acute pain, and caregiver anxiety, the data for this case and his mother were conducted by observation, physical assessment, the process of caring, and communication...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164339/fractional-nuclear-charge-approach-to-isolated-anion-densities-for-hirshfeld-partitioning-methods
#6
Farnaz Heidar-Zadeh, Paul W Ayers, Patrick Bultinck
Atoms in molecules methods that rely on reference promolecular densities typically require that one define, or otherwise determine, the densities of unbound atomic anions. Whereas the isolated atomic polyanions are always physically and computationally unbound, monoanions can be either physically bound but computationally unbound (like the oxygen anion at the Hartree-Fock level of theory), or physically unbound but computationally bound (like the nitrogen anion using many DFT methods with a basis set including diffuse functions)...
November 21, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29164191/characterising-the-evaporation-kinetics-of-water-and-semi-volatile-organic-compounds-from-viscous-multicomponent-organic-aerosol-particles
#7
Stephen Ingram, Chen Cai, Young-Chul Song, David R Glowacki, David O Topping, Simon O'Meara, Jonathan P Reid
The physicochemical changes experienced by organic aerosol particles undergoing dehydration into the surrounding gas phase can be drastic, forcing rapid vitrification of the particle and suppressing internal diffusion. Until recently, experimental studies have concentrated on quantifying diffusional mixing of either water or non-volatile components, while relatively little attention has been paid to the role of semivolatile organic component (SVOC) diffusion and volatilisation in maintaining the equilibrium between the gas and particle phases...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29164087/plasma-brain-derived-neurotrophic-factor-levels-in-newborn-infants-with-neonatal-abstinence-syndrome
#8
Lochan Subedi, Hong Huang, Amrita Pant, Philip M Westgate, Henrietta S Bada, John A Bauer, Peter J Giannone, Thitinart Sithisarn
Background: Brain-derived neurotrophic factor (BDNF) is a type of growth factor that promotes growth and survival of neurons. Fetal exposure to opiates can lead to postnatal withdrawal syndrome, which is referred as neonatal abstinence syndrome (NAS). Preclinical and clinical studies have shown an association between opiates exposure and alteration in BDNF expression in the brain and serum levels in adult. However, to date, there are no data available on the effects of opiate exposure on BDNF levels in infant who are exposed to opiates in utero and whether BDNF level may correlate with the severity of NAS...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29164079/cognitive-and-behavioral-disorders-in-children-with-neurofibromatosis-type-1
#9
REVIEW
Martha Milade Torres Nupan, Alberto Velez Van Meerbeke, Claudia Alejandra López Cabra, Paula Marcela Herrera Gomez
Aim: The last systematic review of research on the behavior of children with neurofibromatosis type 1 (NF1) was in 2012. Since then, several important findings have been published. Therefore, the study aim was to synthesize recent relevant work related to this issue. Method: We conducted a systematic review of the literature. Relevant articles were identified using the electronic databases PubMed, PsycINFO, and Scopus and a manual search of references lists. Thirty of 156 articles identified met the inclusion criteria...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29163990/interventional-pain-management-in-multidisciplinary-chronic-pain-clinics-a-prospective-multicenter-cohort-study-with-one-year-follow-up
#10
Cláudia Gouvinhas, Dalila Veiga, Liliane Mendonça, Rute Sampaio, Luís Filipe Azevedo, José Manuel Castro-Lopes
Background: Interventional Pain Management (IPM) is performed in multidisciplinary chronic pain clinics (MCPC), including a range of invasive techniques to diagnose and treat chronic pain (CP) conditions. Current patterns of use of those techniques in MCPC have not yet been reported. Objective: We aimed to describe quantitatively and qualitatively the use of IPM and other therapeutic procedures performed on-site at four Portuguese MCPC. Methods: A prospective cohort study with one-year follow-up was performed in adult patients...
2017: Pain Research and Treatment
https://www.readbyqxmd.com/read/29163820/role-of-drug-dependent-transporter-modulation-on-the-chemosensitivity-of-cholangiocarcinoma
#11
Nerea Urtasun, Clara Boces-Pascual, Loreto Boix, Jordi Bruix, Marçal Pastor-Anglada, Sandra Pérez-Torras
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with limited therapeutic options. Curative therapy is limited to surgery whereas chemotherapy treatments are the election option for unresectable or metastatic cholangiocarcinoma. Cisplatin plus gemcitabine is the reference chemotherapy regimen, albeit the contribution to the median overall survival barely reaches one year. Drug transporters are undoubtedly a limiting step for drug bioavailability and have been clearly related to chemoresistance...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163150/targeting-dna-repair-through-podophyllotoxin-and-rutin-formulation-in-hematopoietic-radioprotection-an-in-silico-in-vitro-and-in-vivo-study
#12
M H Yashavarddhan, Sandeep K Shukla, Pankaj Chaudhary, Nitya N Srivastava, Jayadev Joshi, Mrutyunjay Suar, Manju L Gupta
Drug discovery field has tremendously progressed during last few decades, however, an effective radiation countermeasure agent for the safe administration to the victims of radiation exposure is still unavailable. This multi-model study is aimed at elucidating the mechanistic aspects of a novel podophyllotoxin and rutin combination (henceforth referred as G-003M) in the hematopoietic radioprotection and its involvement in the DNA damage and repair signaling pathways. Using in silico study, we identified the binding sites and structural components of G-003M and validated in vitro...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162475/-thyrotropin-reference-ranges-during-pregnancy-in-the-province-of-huelva-spain
#13
A Ortega Carpio, I Vázquez Rico, M A Castaño López, L Duarte González, M Montilla Álvaro, A Ruiz Reina
OBJECTIVE: The correct diagnosis of hypothyroidism during pregnancy requires knowledge of the local trimester-specific thyrotropin (TSH) reference ranges. When these are not available, the guidelines recommend upper limits of 2.5, 3.0, and 3.0μU/ml for the 1(st), 2(nd), and 3(rd) trimesters, respectively. The aim is to establish the reference range for our local population. MATERIAL AND METHODS: A population-based observational study was performed on healthy pregnant women from 11 healthcare centres in the province of Huelva...
November 18, 2017: Semergen
https://www.readbyqxmd.com/read/29162069/martius-flap-for-recurrent-perineal-and-rectovaginal-fistulae-in-a-patient-with-crohn-s-disease-endometriosis-and-a-mullerian-anomaly
#14
Gaetano Gallo, Alberto Realis Luc, Giuseppe Clerico, Mario Trompetto
BACKGROUND: Rectovaginal fistulas represent 5% of all anorectal fistulae and are a disastrous manifestation of Crohn's disease that negatively affects patients' social and sexual quality of life. Treatment remains challenging for colorectal surgeons, and the recurrence rate remains high despite the numerous available options. CASE PRESENTATION: We describe a 31-year-old female patient with a Crohn's disease-related recurrent perineo-vaginal and recto-vaginal fistulae and a concomitant mullerian anomaly...
November 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29162067/necrotizing-fasciitis-after-high-dose-rate-brachytherapy-and-external-beam-radiation-for-prostate-cancer-a-case-report
#15
Shimpei Yamashita, Yasuo Kohjimoto, Akinori Iba, Kazuro Kikkawa, Isao Hara
BACKGROUND: In recent years, the delayed side effects associated with radiotherapy for prostate cancer have drawn the interest of urologists. Although urosymphyseal fistula is one of these delayed side effects, this serious complication is rarely described in literature and is poorly recognized. CASE PRESENTATION: We report our experience in treating a 77-year-old male patient with necrotizing fasciitis after high-dose rate brachytherapy plus external beam radiation for prostate cancer...
November 21, 2017: BMC Urology
https://www.readbyqxmd.com/read/29162045/serial-pseudoprogression-of-metastatic-malignant-melanoma-in-a-patient-treated-with-nivolumab-a-case-report
#16
Yukinori Ozaki, Junichi Shindoh, Yuji Miura, Hiromichi Nakajima, Ryosuke Oki, Miyuki Uchiyama, Jun Masuda, Keiichi Kinowaki, Chihiro Kondoh, Yuko Tanabe, Tsuyoshi Tanaka, Shusuke Haruta, Masaki Ueno, Shigehisa Kitano, Takeshi Fujii, Harushi Udagawa, Toshimi Takano
BACKGROUND: Pseudoprogression refers to a specific pattern of response sometimes observed in malignant melanoma patients receiving treatment with immune-checkpoint inhibitors. Although cases with pseudoprogression documented once have been reported previously, there have been no case reports yet of pseudoprogression events documented twice during treatment. CASE PRESENTATION: A 55-year-old man underwent surgery for locally advanced esophageal malignant melanoma and received postoperative adjuvant interferon therapy...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161199/intranasal-budesonide-and-quality-of-life-in-pediatric-sleep-disordered-breathing-a-randomized-controlled-trial
#17
Gunnhildur Gudnadottir, Eva Ellegård, Johan Hellgren
Objective To study the efficacy of budesonide nasal spray on the health-related quality of life and symptoms among children with sleep-disordered breathing. Study Design Randomized, parallel, double-blind, placebo-controlled trial. Setting Tertiary referral center. Subjects and Methods Sixty children (ages, 4-10 years) who were referred because of snoring and/or apneas for >3 months were included between January 2015 and June 2016 and randomized in a double-blind design to treatment with 64 μg/mL of budesonide nasal spray (n = 30) or placebo nasal spray (n = 30) twice daily for 6 weeks...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29160511/the-importance-of-audiometric-monitoring-in-patients-with-multidrug-resistant-tuberculosis
#18
Karla Anacleto de Vasconcelos, Silvana Maria Monte Coelho Frota, Antonio Ruffino-Netto, Afrânio Lineu Kritski
INTRODUCTION: A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patients treated for MDR-TB and to identify associations between these complaints and the type of aminoglycoside used...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29159773/japan-society-of-gynecologic-oncology-guidelines-2015-for-the-treatment-of-vulvar-cancer-and-vaginal-cancer
#19
Toshiaki Saito, Tsutomu Tabata, Hitoshi Ikushima, Hiroyuki Yanai, Hironori Tashiro, Hitoshi Niikura, Takeo Minaguchi, Toshinari Muramatsu, Tsukasa Baba, Wataru Yamagami, Kazuya Ariyoshi, Kimio Ushijima, Mikio Mikami, Satoru Nagase, Masanori Kaneuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Hidetaka Katabuchi
BACKGROUND: Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan. The first version of the Japan Society of Gynecologic Oncology (JSGO) guidelines for the treatment of vulvar cancer and vaginal cancer was published in 2015 in Japanese. OBJECTIVE: The JSGO committee decided to publish the English version of the JSGO guidelines worldwide, and hope it will be a useful guide to physicians in a similar situation as in Japan...
November 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159573/low-baseline-and-subsequent-higher-aortic-abdominal-aneurysm-fdg-uptake-are-associated-with-poor-sac-shrinkage-post-endovascular-repair
#20
Pierre-Yves Marie, Didier Plissonnier, Stéphanie Bravetti, Raphael Coscas, Martin Rouer, Stéphan Haulon, Damien Mandry, Jean-Marc Alsac, Sergueï Malikov, Nicla Settembre, Yann Gouëffic, Olivier Morel, Véronique Roch, Emilien Micard, Zohra Lamiral, Jean-Baptiste Michel, Patrick Rossignol
PURPOSE: The growth phases of medically treated abdominal aortic aneurysms (AAA) are frequently associated with an (18)F-fluorodesoxyglucose positron emission tomography (FDG-PET) pattern involving low baseline and subsequent higher FDG uptake. However, the FDG-PET patterns associated with the endovascular aneurysm repair (EVAR) of larger AAA are presently unknown. This study aimed to investigate the relationship between serial AAA FDG uptake measurements, obtained before EVAR and 1 and 6 months post-intervention and subsequent sac shrinkage at 6 months, a well-recognized indicator of successful repair...
November 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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