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https://www.readbyqxmd.com/read/28535154/randomised-controlled-trial-of-early-prophylactic-feeding-vs-standard-care-in-patients-with-head-and-neck-cancer
#1
Teresa E Brown, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: Weight loss remains significant in patients with head and neck cancer, despite prophylactic gastrostomy and intensive dietary counseling. The aim of this study was to improve outcomes utilising an early nutrition intervention. METHODS: Patients with head and neck cancer at a tertiary hospital in Australia referred for prophylactic gastrostomy prior to curative intent treatment were eligible for this single centre randomised controlled trial. Exclusions included severe malnutrition or dysphagia...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28535116/is-mannitol-the-treatment-of-choice-for-patients-with-ciguatera-fish-poisoning
#2
Michael E Mullins, Robert S Hoffman
CONTEXT: Ciguatera fish poisoning arises primarily from consumption of carnivorous reef fish caught in tropical and sub-tropical waters. Ciguatoxins, a class of tasteless, heat-stable, polycyclic toxins produced by dinoflagellates, accumulate through the food chain and concentrate in various carnivorous fish, such as groupers, barracudas, wrasses, amberjack, kingfishes, and eels. Characteristics of ciguatera fish poisoning include early nausea, vomiting, and diarrhea in the first one to two days post ingestion, followed by the appearance of sensory disturbances...
May 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28534936/forsythoside-a-exerts-an-anti-endotoxin-effect-by-blocking-the-lps-tlr4-signaling-pathway-and-inhibiting-tregs-in-vitro
#3
Xiao-Yan Zeng, Wei Yuan, Lin Zhou, Shi-Xiu Wang, Yong Xie, Ying-Jun Fu
Endotoxins, also referred to as lipopolysaccharides (LPS), are powerful immunostimulators involved in a number of severe diseases. Forsythoside A (FTA), a monomer of phenethyl alcohol glycosides extracted from Forsythia suspensa, has been shown to possess anti-bacterial and immunomodulatory properties. However, it is currently not known whether FTA can counter the adverse effects of endotoxins. We investigated the effect of FTA on LPS-stimulated RAW264.7 cells and primary lymphocytes to determine its molecular mechanism of action...
May 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28534866/-a-comparison-of-methods-for-modeling-factors-associated-with-hospital-admissions-in-incident-cases-of-heart-failure
#4
Francisco Javier Prado-Galbarro, Isabel Del-Cura-González, Sofía Garrido-Elustondo, Ana Estela Gamiño-Arroyo, Carlos Sánchez-Piedra, Antonio Sarriá Santamera
OBJECTIVE: Heart failure (HF) is an important public health problem due to its increasing prevalence, and the decompensation associated with hospital admission represents an increased risk of death. The objective of this study was to compare several methods to model the variable hospitalizations and to determine the effect of factors associated with hospital admissions in incident cases of HF. METHODS: Study of a retrospective cohort of patients with information extracted from electronic medical records of PC was performed...
May 24, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28534681/referral-of-older-thyroid-cancer-patients-to-a-high-volume-surgeon-results-of-a-multidisciplinary-physician-survey
#5
Maria Papaleontiou, Paul G Gauger, Megan R Haymart
OBJECTIVE: Surgical outcomes of thyroid cancer patients are improved with high-volume surgeons. However, age disparities in referral to specialist surgical centers still exist. The factors that influence decision-making regarding referral of older thyroid cancer patients to high-volume surgeons remain unknown. METHODS: We surveyed members of the Endocrine Society, American College of Physicians and American Academy of Family Practice. RESULTS: Overall, 270 physicians completed the survey...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28534313/class-based-chronicities-of-suffering-and-seeking-help-comparing-addiction-treatment-programs-in-uganda
#6
Julia Vorhölter
Based on ethnographic fieldwork, this article looks at changing discourses and practices in the field of mental health care in Uganda. In particular, it analyzes two psychotherapeutic institutions designed to treat drug- and alcohol-addiction, and their accessibility and affordability for people from different class backgrounds. The first center is a high-class residential facility near Kampala which offers state-of-the-art addiction therapy, but is affordable only for the rich. The second center, a church-funded organization in Northern Uganda, cares mainly for people from poor, rural families who cannot afford exp/tensive treatment...
May 22, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28534237/the-buffet-program-development-of-a-cognitive-behavioral-treatment-for-selective-eating-in-youth-with-autism-spectrum-disorder
#7
REVIEW
Emily S Kuschner, Hannah E Morton, Brenna B Maddox, Ashley de Marchena, Laura Gutermuth Anthony, Judy Reaven
Selective eating (often referred to as "picky" eating) is common in individuals with autism spectrum disorder (ASD) across the lifespan. Behavioral interventions are widely used to treat selective eating; however, most of these programs are time intensive, have not been evaluated for use in outpatient settings, and do not typically include youth beyond early childhood. Despite the functional impact and risk for negative outcomes associated with selective eating, there are no empirically supported treatments available for older children, adolescents, or adults, either with or without ASD...
May 22, 2017: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/28534184/evaluation-of-cardiovascular-ischemic-event-rates-in-dasatinib-treated-patients-using-standardized-incidence-ratios
#8
Giuseppe Saglio, Philipp le Coutre, Jorge Cortes, Jiří Mayer, Philip Rowlings, François-Xavier Mahon, Glenn Kroog, Kyna Gooden, Milayna Subar, Neil P Shah
With high survival rates for chronic myeloid leukemia (CML) patients treated with BCR-ABL1 tyrosine kinase inhibitors (TKIs), emerging consequences, such as arterial ischemic events, require consideration when evaluating treatment options. Cardiovascular ischemic event incidence in clinical trials was evaluated in 2712 dasatinib-treated patients with Philadelphia chromosome-positive (Ph+) leukemias from 11 first- and second-line trials (pooled), newly diagnosed CML patients treated with dasatinib or imatinib (DASISION), and prostate cancer patients treated with dasatinib or placebo plus docetaxel/prednisone (READY)...
May 22, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28533805/electronic-brachytherapy-management-of-atypical-fibroxanthoma-report-of-8-lesions
#9
Stephen Doggett, James Brazil, Marketa Limova, Leah Press, Sidney Smith, Jeremy Peck
PURPOSE: To evaluate the suitability of treating atypical fibroxanthoma (AFX), an uncommon skin malignancy, with electronic brachytherapy. MATERIAL AND METHODS: From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent(®), Fremont, California). All lesions received 40 Gy in two fractions per week with 5mm margins. RESULTS: At a median follow-up of 23...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28532698/validation-of-the-mayo-clinic-staging-system-in-determining-prognoses-of-patients-with-perihilar-cholangiocarcinoma
#10
Robert J S Coelen, Marcia P Gaspersz, Tim A Labeur, Jeroen L A van Vugt, Susan van Dieren, François E J A Willemssen, Chung Y Nio, Jan N M IJzermans, Heinz-Josef Klümpen, Bas Groot Koerkamp, Thomas M van Gulik
BACKGROUND AND AIMS: Most systems for staging perihilar cholangiocarcinoma (PHC) have been developed for the minority of patients with resectable disease. The recently developed Mayo Clinic system for staging PHC requires only clinical and radiological variables, but has not yet been validated. We performed a retrospective study to validate the Mayo Clinic staging system. METHODS: We identified consecutive patients with suspected PHC evaluated and treated at 2 tertiary centers in The Netherlands, from January 2002 through December 2014...
May 19, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28531869/a-rare-case-of-subacute-appendicitis-actinomycosis-as-the-final-pathology-reports-a-case-report-and-literature-review
#11
G A Gómez-Torres, O S Ortega-Gárcia, E G Gutierrez-López, C A Carballido-Murguía, J A Flores-Rios, C R López-Lizarraga, C A Bautista López, C F Ploneda-Valencia
INTRODUCTION: Acute appendicitis is the most common indication for an emergency abdominal surgery in the world, with a lifetime incidence of around 10%. Actinomycetes are the etiology of appendicitis in only 0.02%-0.06%, having as the final pathology report a chronic inflammatory response; less than 10% of the cases are diagnosed before surgery. Here, we present the case of a subacute appendicitis secondary to actinomycosis. CASE REPORT: A 39-year-old male presented with a twelve-day evolution of intermittent abdominal pain in the right lower quadrant, treated at the beginning with ciprofloxacin and urinary analgesic...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28531835/postpartum-acute-colonic-pseudo-obstruction-ogilvie-s-syndrome-a-systematic-review-of-case-reports-and-case-series
#12
REVIEW
Pradeep Jayaram, Manoj Mohan, Stephen Lindow, Justin Konje
INTRODUCTION: Ogilvie's Syndrome or Acute Colonic Pseudo-Obstruction (ACPO) is a rare condition characterized by massive dilatation of the colon in the absence of mechanical obstruction. About 10% of all reported cases are related to Obstetric and Gynaecological procedures, Caesarean section being the commonest associated factor. Acute intestinal dilatation, if not treated, may lead to perforation and faecal peritonitis with consequent high morbidity and mortality. MATERIALS AND METHODS: An electronic literature searches were performed in PubMed, EMBASE, Google scholar and hand searches for relevant references were included without any language restriction...
May 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28531456/multi-frequency-bioelectrical-impedance-analysis-bia-compared-to-magnetic-resonance-imaging-mri-for-estimation-of-fat-free-mass-in-colorectal-cancer-patients-treated-with-chemotherapy
#13
Stine S Palle, Line T Møllehave, Zahra Taheri-Kadkhoda, Susanne Johansen, Lisbeth Larsen, Janne W Hansen, Nikolaj K G Jensen, Anette O Elingaard, Alice H Møller, Karen Larsen, Jens R Andersen
BACKGROUND: Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients during the course of their treatments. OBJECTIVE: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer undergoing chemotherapy...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530898/chronic-constipation-update-on-management
#14
REVIEW
Umar Hayat, Mohannad Dugum, Samita Garg
Managing chronic constipation involves identifying and treating secondary causes, instituting lifestyle changes, prescribing pharmacologic and nonpharmacologic therapies, and, occasionally, referring for surgery. Several new drugs have been approved, and others are in the pipeline.
May 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28530895/sexual-dysfunction-in-women-can-we-talk-about-it
#15
REVIEW
Stephanie S Faubion, Sharon J Parish
Sexual dysfunction in women is common and often goes unreported and untreated. Its management is part of patient-centered primary care. Primary care providers are uniquely positioned to identify and assess sexual health concerns of their patients, provide reassurance regarding normal sexual function, and treat sexual dysfunction or refer as appropriate.
May 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28530786/morphine-for-chronic-neuropathic-pain-in-adults
#16
REVIEW
Tess E Cooper, Junqiao Chen, Philip J Wiffen, Sheena Derry, Daniel B Carr, Dominic Aldington, Peter Cole, R Andrew Moore
BACKGROUND: Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the nervous system. Opioid drugs, including morphine, are commonly used to treat neuropathic pain...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28530617/-principles-of-urinary-tract-reconstructive-surgery
#17
Juan Gomez Rivas, Jesús Cisneros Ledo
INTRODUCTION: In the last 15 years, the role of laparoscopic surgery has progressively increased to include reconstructive procedures such as pyeloplasty and management of ureteral stricture, in addition to being a field in continuous development, this refers to the improvement of ergonomics, new instruments and new techniques. We present a review on basic features of laparoscopic reconstructive surgery in urology. ACQUISITION OF EVIDENCE: For this review, an exhaustive literature search was performed in PUBMED, MEDILNE, BioMed central and others, with the keywords: reconstructive surgery, urology, laparoscopy...
May 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28530214/-the-long-term-treatment-outcomes-of-adult-osteosarcoma
#18
Iwowa Ługowska, Andrzej Pieńkowski, Anna Szumera-Ciećkiewicz, Hanna Koseła-Paterczyk, Pawel Teterycz, Maciej Głogowski, Katarzyna Kozak, Anna Klimczak, Slawomir Falkowski, Piotr Rutkowski
Osteosarcoma is the most common primary bone tumor. Treatment of osteosarcoma patients is based on chemotherapy as well as surgical resection of primary tumor and distant metastases. Lung metastases are the primary cause of death in this group of patients. AIM: The aim of this study is to summarize the 20 years of osteosarcoma treatment outcomes in the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology in Warsaw. MATERIALS AND METHODS: Our analysis included clinical data of 299 osteosarcoma patients aged between 14 and 81 years (median 32) treated in Maria Sklodowska-Curie Memorial Cancer Center between 1998 and 2016...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28529679/new-era-of-electronic-brachytherapy
#19
EDITORIAL
Prabhakar Ramachandran
Traditional brachytherapy refers to the placement of radioactive sources on or inside the cancer tissues. Based on the type of sources, brachytherapy can be classified as radionuclide and electronic brachytherapy. Electronic brachytherapy uses miniaturized X-ray sources instead of radionuclides to deliver high doses of radiation. The advantages of electronic brachytherapy include low dose to organs at risk, reduced dose to treating staff, no leakage radiation in off state, less shielding, and no radioactive waste...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28529557/a-single-center-experience-of-sorafenib-monotherapy-in-patients-with-advanced-intrahepatic-cholangiocarcinoma
#20
Ting-Ting Pan, Wei Wang, Wei-Dong Jia, Ge-Liang Xu
Patients with advanced intrahepatic cholangiocarcinoma (ICC) have a poor prognosis and the therapeutic options available for treating ICC are limited. Sorafenib, a multikinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet derived growth factor receptor-β, B-Raf proto-oncogene, serine/threonine kinase and C-Raf proto-oncogene, serine/threonine kinase, is a novel reference standard for the treatment of advanced hepatocellular carcinoma. Sorafenib has previously been demonstrated to exhibit significant antitumor activity in various cholangiocarcinoma cell lines and in xenograft ICC models...
May 2017: Oncology Letters
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