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https://www.readbyqxmd.com/read/28805967/prognostic-value-of-exercise-capacity-among-men-undergoing-pharmacologic-treatment-for-erectile-dysfunction-the-fit-project
#1
Robert V Same, Mahmoud Al Rifai, David I Feldman, Kevin L Billups, Clinton A Brawner, Zeina A Dardari, Jonathan K Ehrman, Steven J Keteyian, Mouaz H Al-Mallah, Michael J Blaha
BACKGROUND: Vascular erectile dysfunction (ED) has been identified as a potentially useful risk factor for predicting future cardiovascular events, particularly in younger men. Because these men typically score more favorably on traditional cardiovascular disease risk assessment tools, there exists a gap in knowledge for how to most appropriately identify those men who would benefit from more aggressive treatments. To date, no studies have examined the impact of fitness on cardiovascular outcomes in men with ED...
August 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28805613/a-complicated-urethrovaginal-fistula-following-an-inappropriate-urethral-diverticulum-management
#2
Tsia-Shu Lo, Sukanda Bin Jaili, Rami Ibrahim
OBJECTIVE: Urethral diverticulum is uncommon, therefore appropriate evaluation, preoperative planning and counseling must be done in order to make correct diagnosis and prevent complications. MATERIALS AND METHODS: A case of anterior vaginal wall mass was treated elsewhere by a gynecologist as periurethral cyst abscess; incision and drainage were done but a symptom of pus discharge was observed after 2 weeks. Therefore, exploration, cyst wall excision and primary closure were done though histopathological examination surprisingly confirmed the presence of urethral tissue suggestive of diverticulum...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28805103/dentoalveolar-oral-surgery-in-children-and-adolescents-organization-and-surgical-treatment-in-a-large-danish-municipal-dental-service
#3
Anni Birgitte Grønbæk, Flemming Petersen, Dorte Haubek, Sven Poulsen
OBJECTIVE: To describe a population-based organization of dentoalveolar surgical service for 0 to 18-year old subjects in a Danish municipal dental service, and analyze the type of dentoalveolar surgical interventions needed. MATERIAL AND METHODS: The study was conducted in the Municipality of Aarhus, Denmark during five consecutive school-years. An internal referral system was established within the municipality where patients could be referred to colleagues with a higher level of competencies and more experiences with paediatric dentoalveolar surgery...
August 13, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28804922/study-of-cognitive-function-in-children-treated-with-propranolol-for-infantile-hemangioma
#4
Nieves González-Llorente, Isabel Del Olmo-Benito, Natalia Muñoz-Ollero, Miguel Angel Descalzo, Ignacio García-Doval, Antonio Torrelo
BACKGROUND: Oral propranolol is considered the first choice for the treatment of infantile hemangiomas (IHs). There is a concern that administering propranolol in newborns and infants could induce adverse effects in learning and memory processes in the long term. The purpose of this study was to assess cognitive and memory functions in children who had been treated with propranolol for IH during their infancy. METHODS: A total of 23 children between 5 and 7.5 years of age who had been treated with oral propranolol for IH during infancy were tested for cognitive functions with the Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition (WPPSI-IV) test and for memory functions with the Test of Memory and Learning (TOMAL)...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28803708/anti-phospholipid-syndrome-current-opinion-on-mechanisms-involved-laboratory-characterization-and-diagnostic-aspects
#5
REVIEW
Jean Amiral, Marie Peyrafitte, Claire Dunois, Anne Marie Vissac, Jerard Seghatchian
Anti-phospholipid syndrome is a complex and severe clinical situation, associated with symptoms such as recurrent thrombosis, arterial or venous, at any site, pregnancy loss, and other related syndromes. These clinical burdens, are highly variable from patient to patient, and are associated with biological abnormalities, such as the presence of the Lupus Anticoagulant or phospholipid dependent antibodies, confirmed on two occasions at least 12 weeks apart. From the diagnosis standpoint, both, functional (clotting) or immunological assays, are difficult to standardize and to optimize, due to the absence of reference material, or a characteristic clinical group, and international reference preparations...
July 15, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28803668/when-does-atopic-dermatitis-warrant-systemic-therapy-recommendations-from-an-expert-panel-of-the-international-eczema-council
#6
Eric L Simpson, Marjolein Bruin-Weller, Carsten Flohr, Michael R Ardern-Jones, Sebastien Barbarot, Mette Deleuran, Thomas Bieber, Christian Vestergaard, Sara J Brown, Michael J Cork, Aaron M Drucker, Lawrence F Eichenfield, Regina Foelster-Holst, Emma Guttman-Yassky, Audrey Nosbaum, Nick J Reynolds, Jonathan I Silverberg, Jochen Schmitt, Marieke M B Seyger, Phyllis I Spuls, Jean-Francois Stalder, John C Su, Roberto Takaoka, Claudia Traidl-Hoffmann, Jacob P Thyssen, Jorien van der Schaft, Andreas Wollenberg, Alan D Irvine, Amy S Paller
BACKGROUND: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. OBJECTIVE: To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy...
August 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28803169/stereotactic-radiosurgery-for-dural-arteriovenous-fistulas-without-cortical-venous-reflux
#7
Daniel A Tonetti, Bradley A Gross, Brian T Jankowitz, Kyle M Atcheson, Hideyuki Kano, Edward A Monaco, Ajay Niranjan, L Dade Lunsford
BACKGROUND: The rationale for treatment of dural arteriovenous fistulas (dAVF) without cortical venous reflux is symptomatic resolution. Most studies of dural arteriovenous fistula treatment, including those for stereotactic radiosurgery (SRS), have focused on angiographic obliteration instead of clinical symptomatic outcome. METHODS: The authors evaluated their institutional experience with SRS for cerebral dAVFs without cortical venous reflux from 1991 to 2016, evaluating angiographic and clinical outcomes, focusing on the course of pulsatile tinnitus and/or ocular symptoms after treatment...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28802231/phytochemical-properties-and-pharmacological-effects-of-quercus-ilex-l-aqueous-extract-on-gastrointestinal-physiological-parameters-in-vitro-and-in-vivo
#8
Kaïs Rtibi, Imen Hammami, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki
INTRODUCTION: Several research studies have reported on the pharmacological relevance of the medicinal plants used for treating various gastrointestinal disorders and controlling the dietary glucose uptake in the intestinal tract. METHODS: Male rats were used to investigate the pharmacological effects of green oak acorn aqueous extract (GOAE) on gastrointestinal physiological parameters in vivo and in vitro. In this respect, the gastro-intestinal motility and hypersecretion essays were evaluated using a simple test meal (10% charcoal in 5% gum arabic) and castor oil induced diarrhea...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28801832/simultaneous-measurement-of-total-estradiol-and-testosterone-in-human-serum-by-isotope-dilution-liquid-chromatography-tandem-mass-spectrometry
#9
Hui Zhou, Yuesong Wang, Matthew Gatcombe, Jacob Farris, Julianne C Botelho, Samuel P Caudill, Hubert W Vesper
Reliable measurement of total testosterone and estradiol is critical for their use as biomarkers of hormone-related disorders in patient care and translational research. We developed and validated a mass spectrometry method to simultaneously quantify these analytes in human serum without chemical derivatization. Serum is equilibrated with isotopic internal standards and treated with acidic buffer to release hormones from their binding proteins. Lipids are isolated and polar impurities are removed by two serial liquid-liquid extraction steps...
August 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28801780/a-case-of-acetaminophen-induced-acute-tubulointerstitial-nephritis-in-adult
#10
Dan Inoue, Ryosuke Usui, Kosaku Nitta, Minako Koike
We report a case of allergic acute tubulointerstitial nephritis (TIN) induced by acetaminophen in a 48-year-old Japanese man with no past medical history. Two days after receiving the non-steroidal anti-inflammatory drug (NSAID) loxoprofen for left shoulder pain, he developed cold symptoms such as fever and sore throat. He then took a 300 mg dose of acetaminophen three times a day and a 100 mg dose of minocycline hydrochloride twice a day for 7 days. Because there was no improvement in his symptoms, he consulted a local clinic again, where blood tests revealed renal insufficiency, and he was, then, referred to our hospital for evaluation of kidney function...
August 11, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28800882/salvianolic-acid-b-inhibits-intermittent-high-glucose-induced-ins-1-cell-apoptosis-through-regulation-of-bcl-2-proteins-and-mitochondrial-membrane-potential
#11
Shanjun Tao, Younan Ren, Haowen Zheng, Mengqiu Zhao, Xu Zhang, Yuanmei Zhu, Jieren Yang, Shuguo Zheng
Blood glucose fluctuations, also referred to as intermittent high glucose, have been validated to be more harmful than sustained high glucose in exacerbating pancreatic dysfunction by inducing β cell apoptosis. Salvianolic acid B (Sal B), an aqueous component of Salvia miltiorrhiza, has been proved beneficial to pancreatic islet function in diabetes, but the underlying mechanisms remain to be elucidated. The present study investigated the protective effect of Sal B on INS-1 cells exposed to intermittent high glucose and the possible mechanisms implicated...
August 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28800211/pharmacokinetics-and-bioequivalence-of-branded-and-generic-formulations-of-dofetilide-0-5-mg-capsules-after-single-dose-administration-in-healthy-subjects
#12
James T VanderLugt, Charles Bon, Dean Knuth, Rhonda Schreiber, Michael D Ruff
Class III antiarrhythmics are preferred therapy for managing atrial fibrillation/flutter. Dofetilide 0.5-mg capsules were US Food and Drug Administration (FDA) approved in 1999 to treat atrial fibrillation/flutter. Bioequivalence of generic dofetilide is important for treating arrhythmias because drug concentrations must be consistent to maintain normal sinus rhythm. Generic dofetilide 0.5-mg capsule pharmacokinetics were compared with branded product in 2 open-label, 2-way crossover, single-dose studies - 1 study each in fasted and fed healthy subjects...
August 11, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28799954/effects-of-systemic-glutamatergic-manipulations-on-conditioned-eyeblink-responses-and-hyperarousal-in-a-rabbit-model-of-post-traumatic-stress-disorder
#13
Lauren B Burhans, Carrie A Smith-Bell, Bernard G Schreurs
Glutamatergic dysfunction is implicated in many neuropsychiatric conditions, including post-traumatic stress disorder (PTSD). Glutamate antagonists have shown some utility in treating PTSD symptoms, whereas glutamate agonists may facilitate cognitive behavioral therapy outcomes. We have developed an animal model of PTSD, based on conditioning of the rabbit's eyeblink response, that addresses two key features: conditioned responses (CRs) to cues associated with an aversive event and a form of conditioned hyperarousal referred to as conditioning-specific reflex modification (CRM)...
August 9, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28799250/extracellular-vesicles-nature-s-nanoparticles-for-improving-gene-transfer-with-adeno-associated-virus-vectors
#14
REVIEW
Bence György, Casey A Maguire
Gene therapy, the ability to treat a disease at the level of nucleic acid, has journeyed from science fiction, to hard lessons learned from early clinical trials, to improved technologies with efficacy in patients for several diseases. Adeno-associated virus (AAV) vectors are currently a leader for direct in vivo gene therapy. To date, AAV is safe in patients, with clinical benefit in trials to treat blindness, hemophilia, and a lipid disorder, with many more trials underway. Despite this remarkable progress, barriers exist for AAV vectors to be effective gene transfer vehicles in all organ/cell targets, as well as patient subpopulations...
August 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28799197/cost-effectiveness-of-the-family-nurse-partnership-fnp-programme-in-england-evidence-from-the-building-blocks-trial
#15
Belen Corbacho, Kerry Bell, Eugena Stamuli, Gerry Richardson, Sarah Ronaldson, Kerenza Hood, Julia Sanders, Michael Robling, David Torgerson
RATIONAL, AIMS, AND OBJECTIVES: The Family Nurse Partnership (FNP) is a licensed intensive home visiting intervention developed in the United States. It has been provided in England by the Department of Health since 2006. The Building Blocks trial assessed the effectiveness and cost-effectiveness of FNP in England. METHODS: We performed a cost-utility analysis (National Health Service (NHS) perspective) alongside the Building Blocks trial (over 2.5 y). The analysis was conducted in accordance with National Institute for Health and Clinical Excellence (NICE) reference case standards...
August 11, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28798903/anti-quorum-sensing-and-anti-biofilm-activity-of-delftia-tsuruhatensis-extract-by-attenuating-the-quorum-sensing-controlled-virulence-factor-production-in-pseudomonas-aeruginosa
#16
Vijay K Singh, Avinash Mishra, Bhavanath Jha
Multidrug-resistance bacteria commonly use cell-to-cell communication that leads to biofilm formation as one of the mechanisms for developing resistance. Quorum sensing inhibition (QSI) is an effective approach for the prevention of biofilm formation. A Gram-negative bacterium, Delftia tsuruhatensis SJ01, was isolated from the rhizosphere of a species of sedge (Cyperus laevigatus) grown along the coastal-saline area. The isolate SJ01 culture and bacterial crude extract showed QSI activity in the biosensor plate containing the reference strain Chromobacterium violaceum CV026...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28798268/how-safe-and-effective-are-existing-treatments-for-wide-necked-bifurcation-aneurysms-literature-based-objective-performance-criteria-for-safety-and-effectiveness
#17
REVIEW
David Fiorella, Adam S Arthur, Richard Chiacchierini, Evelyne Emery, Andy Molyneux, Laurent Pierot
INTRODUCTION: Wide-necked bifurcation aneurysms (WNBAs) present unique technical challenges for both endovascular and surgical treatments which aim to achieve complete occlusion of the aneurysm without compromising the patency of the incorporated regional parent vessels. We present a meta-analysis of traditional therapies for WNBAs to provide critical benchmarks for safety and effectiveness. METHODS: Following a systematic search of the literature and the application of pre-specified appropriateness criteria, 43 (including 2794 aneurysms treated) and 65 (including 5366 patients treated) references with sufficient detail were identified to include in a meta-analysis of efficacy and safety, respectively...
August 10, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28797573/digestive-decontamination-in-burn-patients-a-systematic-review-of-randomized-clinical-trials-and-observational-studies
#18
REVIEW
Mercedes Rubio-Regidor, Ana Martín-Pellicer, Luciano Silvestri, Hendrik K F van Saene, José A Lorente, Miguel A de la Cal
OBJECTIVE: The objective of this systematic review is to assess the effect of selective digestive decontamination (SDD) or non-absorbable enteral antibiotics (EA) on mortality, the incidence of infection and its adverse effects in burn patients. MATERIAL AND METHODS: Systematic review of randomized clinical trials (RCT) or observational studies enrolling burn patients, and comparing SDD or EA prophylaxis with placebo or no treatment. The search includes Pubmed/Medline, EMBASE, WOS, Cochrane Library (1970-2015)...
August 7, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28797265/risk-and-predictors-of-psoriasis-in-patients-with-breast-cancer-a-swedish-population-based-cohort-study
#19
Haomin Yang, Judith S Brand, Jingmei Li, Jonas F Ludvigsson, Emilio Ugalde-Morales, Flaminia Chiesa, Per Hall, Kamila Czene
BACKGROUND: The risk of psoriasis in patients with breast cancer is largely unknown, as available evidence is limited to case findings. We systematically examined the incidence and risk factors of psoriasis in patients with breast cancer. METHODS: A Swedish nationwide cohort of 56,235 breast cancer patients (2001-2012) was compared to 280,854 matched reference individuals from the general population to estimate the incidence and hazard ratio (HR) of new-onset psoriasis...
August 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28797240/a-comparison-of-illumina-and-ion-torrent-sequencing-platforms-in-the-context-of-differential-gene-expression
#20
Nicholas F Lahens, Emanuela Ricciotti, Olga Smirnova, Erik Toorens, Eun Ji Kim, Giacomo Baruzzo, Katharina E Hayer, Tapan Ganguly, Jonathan Schug, Gregory R Grant
BACKGROUND: Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analysis. Previous investigations of this question have typically used reference samples derived from cell lines and brain tissue, and do not involve biological variability. While these comparisons might inform studies of tissue-specific expression, marked by large-scale transcriptional differences, this is not the common use case...
August 10, 2017: BMC Genomics
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