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https://www.readbyqxmd.com/read/28724419/real-life-clinical-practice-results-with-vinflunine-in-patients-with-relapsed-platinum-treated-metastatic-urothelial-carcinoma-an-italian-multicenter-study-movie-goirc-01-2014
#1
Rodolfo Passalacqua, Silvia Lazzarelli, Maddalena Donini, Rodolfo Montironi, Rosa Tambaro, Ugo De Giorgi, Sandro Pignata, Raffaella Palumbo, Giovanni Luca Ceresoli, Gianluca Del Conte, Giuseppe Tonini, Franco Morelli, Franco Nolè, Stefano Panni, Ermanno Rondini, Annalisa Guida, Paolo Andrea Zucali, Laura Doni, Elisa Iezzi, Caterina Caminiti
BACKGROUND: Vinflunine is the only chemotherapeutic agent shown to improve survival in platinum-refractory patients with metastatic transitional cell carcinoma of the urothelium (TCCU) in a phase III clinical trial, which led to product registration for this indication in Europe. The aim of this study was to assess the efficacy of vinflunine and to evaluate the prognostic significance of risk factors in a large, unselected cohort of patients with metastatic TCCU treated according to routine clinical practice...
July 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28719093/bone-marrow-harvest-from-unrelated-donors-up-to-date-methodology
#2
Katarzyna Pruszczyk, Kamila Skwierawska, Małgorzata Król, Albert Moskowicz, Dariusz Jabłoński, Tigran Torosian, Iwona Piotrowska, Elżbieta Urbanowska, Wiesław Wiktor-Jędrzejczak, Emilian Snarski
OBJECTIVES: Bone marrow harvesting is one of the essential sources of stem cells for hematopoietic stem cell transplantation. We describe here the current "up to date" standard of the bone marrow harvest in unrelated stem cell donors. METHODS: We analyzed medical data of 187 unrelated hematopoietic stem cell donors who underwent bone marrow harvest without previous peripheral blood stem collection at the center between 2011 and 2015. The methodology of marrow collection includes multiple cells aimed at safety of the procedure e...
July 18, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28718717/movies-in-mind-dr-strange-i-think-i-am-a-receptor-%C3%A2-therefore-i-am
#3
Sumit Anand
No abstract text is available yet for this article.
August 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28716768/effect-of-viewing-smoking-scenes-in-motion-pictures-on-subsequent-smoking-desire-in-audiences-in-south-korea
#4
Minsung Sohn, Minsoo Jung
BACKGROUND: In the modern era of heightened awareness of public health, smoking scenes in movies remain relatively free from public monitoring. The effect of smoking scenes in movies on the promotion of viewers' smoking desire remains unknown. OBJECTIVE: The study aimed to explore whether exposure of adolescent smokers to images of smoking in fılms could stimulate smoking behavior. METHODS: Data were derived from a national Web-based sample survey of 748 Korean high-school students...
July 17, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28716648/applications-of-high-speed-atomic-force-microscopy-to-real-time-visualization-of-dynamic-biomolecular-processes
#5
REVIEW
Takayuki Uchihashi, Simon Scheuring
BACKGROUND: Many biological processes in a living cell are consequences of sequential and hierarchical dynamic events of biological macromolecules such as molecular interactions and conformational changes. Hence, knowledge of structures, assembly and dynamics of proteins is the foundation for understanding how biological molecules work. Among several techniques to analyze dynamics of proteins, high-speed atomic force microscopy (HS-AFM) is unique to provide direct information about both structure and dynamics of single proteins at work...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28715250/the-development-of-technology-for-effective-respiratory-gated-irradiation-using-an-image-guided-small-animal-irradiator
#6
M A Hill, J Thompson, A Kavanagh, I D C Tullis, R G Newman, J Prentice, J Beech, S Gilchrist, S Smart, E Fokas, B Vojnovic
The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to maximize tumor dose while sparing normal tissues. However, the current commercial platforms do not incorporate respiratory gating, which is required for accurate and precise targeting in organs subject to respiration related motions that may be up to the order of 5 mm in mice...
July 17, 2017: Radiation Research
https://www.readbyqxmd.com/read/28714684/the-surface-of-protein-%C3%AE-6-85-can-act-as-a-template-for-recurring-peg-structure
#7
Shu-Han Chao, Jan Schaefer, Martin Gruebele
PEGylated proteins play an increasingly important role in pharmaceutical drug delivery. We recently showed that short PEG chains can affect protein structure, even when they are not making extensive contact with the protein surface. In contrast, PEG is generally assumed to form a relatively unstructured coil, whose compactness depends on solvent conditions. Here we test whether a host protein could allow PEG to form recurrent structural motifs while the PEG chain is in contact with the protein surface. We link a PEG oligomer (n=45) to one of two nearly opposite locations on the small alpha-helical protein 6-85 to investigate this question...
July 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28712977/food-marketing-with-movie-character-toys-effects-on-young-children-s-preferences-for-unhealthy-and-healthier-fast-food-meals
#8
Helen Dixon, Philippa Niven, Maree Scully, Melanie Wakefield
This study aimed to test whether movie tie-in premiums (MTIPs) accompanying unhealthy and healthier fast food meals influenced children's meal preferences and their perceptions of these meals. Nine hundred and four Grade 1 and 2 students (aged 5-9 years) from Melbourne, Australia participated in a between-subjects online experiment comprising the following conditions: (A) unhealthy and healthier meals with no MTIP (control); (B) unhealthy and healthier meals with MTIP (current situation in Australia); (C) unhealthy meals with MTIP and healthier meals without MTIP; (D) unhealthy meals without MTIP and healthier meals with MTIP...
July 13, 2017: Appetite
https://www.readbyqxmd.com/read/28711988/emotion-recognition-based-on-eeg-features-in-movie-clips-with-channel-selection
#9
Mehmet Siraç Özerdem, Hasan Polat
Emotion plays an important role in human interaction. People can explain their emotions in terms of word, voice intonation, facial expression, and body language. However, brain-computer interface (BCI) systems have not reached the desired level to interpret emotions. Automatic emotion recognition based on BCI systems has been a topic of great research in the last few decades. Electroencephalogram (EEG) signals are one of the most crucial resources for these systems. The main advantage of using EEG signals is that it reflects real emotion and can easily be processed by computer systems...
July 15, 2017: Brain Informatics
https://www.readbyqxmd.com/read/28706171/-hermeneutic-phenomenological-study-on-caring-experience-of-spouses-of-elderly-people-with-dementia-at-home
#10
Hye Young Jang, Myungsun Yi
PURPOSE: This study aimed to understand and describe the caring experiences of spouses of elderly people with dementia. METHODS: The hermeneutic phenomenological method was used and participants were 12 spouses aged 65 and over who were taking care of their husbands or wives with dementia at home. Data were collected from individual in-depth interviews on participants' actual caring experiences. Additionally, novels, movies, and memoirs on elderly couples with partner who had dementia were included as data for the analysis...
June 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28706169/-the-effect-of-a-movie-based-nursing-intervention-program-on-rehabilitation-motivation-and-depression-in-stroke-patients
#11
Hye Kyung Kwon, Sook Ja Lee
PURPOSE: The aim of this study was to develop and measure the effect of a movie-based-nursing intervention program designed to enhance motivation for rehabilitation and reduce depression levels in stroke patients. METHODS: The study used a quasi-experimental, nonequivalent control group and a pretest-posttest design. The 60 research subjects were assigned to the experimental (n=30) or control group (n=30). The moviebased nursing intervention program was provided for the experimental group during 60-minute sessions held once per week for 10 weeks...
June 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28702058/effectiveness-of-audiovisual-distraction-in-behavior-modification-during-dental-caries-assessment-and-sealant-placement-in-children-with-autism-spectrum-disorder
#12
Kausar Sadia Fakhruddin, Hisham Yehia El Batawi
BACKGROUND: The aim of this study was to evaluate the effectiveness of audiovisual (AV) distraction in behavior modification during dental caries assessment and sealant placement in children with autism spectrum disorder. MATERIALS AND METHODS: This study was conducted on 28 children diagnosed with autism spectrum disorder, aged 6.5-9.8 years. Children underwent one introductory (desensitization) appointment and three treatment sessions. During the introductory session, children had the procedures explained to them, they watched a movie projected on a screen while oral screening and assessment of cooperation level were carried out...
May 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28700573/crispr-cas-encoding-of-a-digital-movie-into-the-genomes-of-a-population-of-living-bacteria
#13
Seth L Shipman, Jeff Nivala, Jeffrey D Macklis, George M Church
DNA is an excellent medium for archiving data. Recent efforts have illustrated the potential for information storage in DNA using synthesized oligonucleotides assembled in vitro. A relatively unexplored avenue of information storage in DNA is the ability to write information into the genome of a living cell by the addition of nucleotides over time. Using the Cas1-Cas2 integrase, the CRISPR-Cas microbial immune system stores the nucleotide content of invading viruses to confer adaptive immunity. When harnessed, this system has the potential to write arbitrary information into the genome...
July 12, 2017: Nature
https://www.readbyqxmd.com/read/28696097/chemical-reactions-of-molecules-promoted-and-simultaneously-imaged-by-the-electron-beam-in-transmission-electron-microscopy
#14
Stephen T Skowron, Thomas W Chamberlain, Johannes Biskupek, Ute Kaiser, Elena Besley, Andrei N Khlobystov
The main objective of this Account is to assess the challenges of transmission electron microscopy (TEM) of molecules, based on over 15 years of our work in this field, and to outline the opportunities in studying chemical reactions under the electron beam (e-beam). During TEM imaging of an individual molecule adsorbed on an atomically thin substrate, such as graphene or a carbon nanotube, the e-beam transfers kinetic energy to atoms of the molecule, displacing them from equilibrium positions. Impact of the e-beam triggers bond dissociation and various chemical reactions which can be imaged concurrently with their activation by the e-beam and can be presented as stop-frame movies...
July 11, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28691861/a-virtual-reality-intervention-to-improve-the-understanding-and-empathy-for-people-with-dementia-in-informal-caregivers-results-of-a-pilot-study
#15
Eva M Wijma, Marjolein A Veerbeek, Marleen Prins, Anne Margriet Pot, Bernadette M Willemse
OBJECTIVE: Informal caregivers often experience psychological distress due to the changing functioning of the person with dementia they care for. Improved understanding of the person with dementia reduces psychological distress. To enhance understanding and empathy in caregivers, an innovative technology virtual reality intervention Through the D'mentia Lens (TDL) was developed to experience dementia, consisting of a virtual reality simulation movie and e-course. A pilot study of TDL was conducted...
July 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28689053/schema-benefit-vs-proactive-interference-contradicting-behavioral-outcomes-and-coexisting-neural-patterns
#16
Noga Oren, Irit Shapira-Lichter, Yulia Lerner, Ricardo Tarrasch, Talma Hendler, Nir Giladi, Elissa L Ash
Prior knowledge can either assist or hinder the ability to learn new information. These contradicting behavioral outcomes, referred to as schema benefit and proactive interference respectively, have been studied separately. Here we examined whether the known neural correlates of each process coexist, and how they are influenced by attentional loading and aging. To this end we used an fMRI task that affected both processes simultaneously by presenting pairs of related short movies in succession. The first movie of each pair provided context for the second movie, which could evoke schema benefit and/or proactive interference...
July 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28685747/assessing-tumor-angiogenesis-in-colorectal-cancer-by-quantitative-contrast-enhanced-endoscopic-ultrasound-and-molecular-and-immunohistochemical-analysis
#17
Elena-Tatiana Cartana, Dan Ionuţ Gheonea, Irina Florina Cherciu, Ioana Streaţa, Constantin-Daniel Uscatu, Elena-Raluca Nicoli, Mihai Ioana, Daniel Pirici, Claudia-Valentina Georgescu, Dragoş-Ovidiu Alexandru, Valeriu Şurlin, Gabriel Gruionu, Adrian Săftoiu
BACKGROUND AND OBJECTIVES: Data on contrast-enhanced endoscopic ultrasound (CE-EUS) for colorectal cancer (CRC) evaluation are scarce. Therefore, we aimed to assess the vascular perfusion pattern in CRC by quantitative CE-EUS and compare it to immunohistochemical and genetic markers of angiogenesis. PATIENTS AND METHODS: We performed a retrospective analysis of CE-EUS examinations of 42 CRC patients, before any therapy. CE-EUS movies were processed using a dedicated software...
July 6, 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28683568/the-effect-of-being-imitated-on-empathy-for-pain-in-adults-with-high-functioning-autism-disturbed-self-other-distinction-leads-to-altered-empathic-responding
#18
Lize De Coster, Jan R Wiersema, Eliane Deschrijver, Marcel Brass
Autism spectrum disorder is a neurodevelopmental disorder that is associated with problems in empathy. Recent research suggests that impaired control over self-other overlap based on motor representations in individuals with autism spectrum disorder might underlie these difficulties. In order to investigate the relationship of self-other distinction and empathy for pain in high-functioning autism and matched controls, we manipulated self-other distinction by using a paradigm in which participants are either imitated or not by a hand on a computer screen...
June 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28683057/tobacco-use-in-top-grossing-movies-united-states-2010-2016
#19
Michael A Tynan, Jonathan R Polansky, Kori Titus, Renata Atayeva, Stanton A Glantz
The Surgeon General has concluded that there is a causal relationship between depictions of smoking in the movies and the initiation of smoking among young persons (1). The more youths see smoking on screen, the more likely they are to start smoking; youths who are heavily exposed to onscreen smoking imagery are approximately two to three times as likely to begin smoking as are youths who receive less exposure (1,2). A Healthy People 2020 objective is to reduce the proportion of youths exposed to onscreen tobacco marketing in movies and television (Tobacco Use Objective 18...
July 7, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28682032/-diabetic-nephropathy-and-cardiovascular-risk
#20
Luigi Rossi, Loreto Gesualdo
The curious case of the Diabetic Nephropathy (DN) : paraphrasing the name of a famous movie is certainly an unusual way to deal with a medical-scientific issue, but it could be extremely functional. Benjamin Button, with his backward life, breaks the unquestionable certainty of human life progressing through fixed steps. Similarly, the knowledge of DN seems go backwards; therefore, although it is a pathology which clinicians are usually sure, maybe too sure, they know every aspect of, the clinical nephrologist managing a diabetic patient often finds himself/herself far from his/her old certainties and proper answers...
March 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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