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https://www.readbyqxmd.com/read/29782993/generalized-recurrent-neural-network-accommodating-dynamic-causal-modeling-for-functional-mri-analysis
#1
Yuan Wang, Yao Wang, Yvonne W Lui
Dynamic Causal Modeling (DCM) is an advanced biophysical model which explicitly describes the entire process from experimental stimuli to functional magnetic resonance imaging (fMRI) signals via neural activity and cerebral hemodynamics. To conduct a DCM study, one needs to represent the experimental stimuli as a compact vector-valued function of time, which is hard in complex tasks such as book reading and natural movie watching. Deep learning provides the state-of-the-art signal representation solution, encoding complex signals into compact dense vectors while preserving the essence of the original signals...
May 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29782815/reprint-of-initial-uncertainty-impacts-statistical-learning-in-sound-sequence-processing
#2
Juanita Todd, Alexander Provost, Lisa Whitson, Daniel Mullens
This paper features two studies confirming a lasting impact of first learning on how subsequent experience is weighted in early relevance-filtering processes. In both studies participants were exposed to sequences of sound that contained a regular pattern on two different timescales. Regular patterning in sound is readily detected by the auditory system and used to form "prediction models" that define the most likely properties of sound to be encountered in a given context. The presence and strength of these prediction models is inferred from changes in automatically elicited components of auditory evoked potentials...
May 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29782372/keeping-up-with-today-s-top-health-law-issues-to-avoid-a-nasty-surprise
#3
Joseph Baar Topinka
Just as in fictional television shows and movies, reality in the healthcare industry sometimes includes complications, disruptions, glitches, and nasty surprises. This article reviews several important legal topics, including emergency planning, privacy, fraud, public health, and ethics, to name only a few. Healthcare administrators are not expected to be attorneys or compliance officers, but they must appreciate (or at least be sensitive to) the legal and regulatory issues facing their organizations.
2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29771630/septins-regulate-junctional-integrity-of-endothelial-monolayers
#4
Joanna Kim, John A Cooper
Junctional integrity of endothelial monolayers is crucial to control movement of molecules and cells across the endothelium. Examining the structure and dynamics of cell junctions in endothelial monolayers, we discovered a role for septins. Contacts between adjacent endothelial cells were dynamic, with protrusions extending above or below neighboring cells. VE-cadherin was present at cell junctions, with a membrane-associated layer of F-actin. Septins localized at cell-junction membranes, in patterns distinct from VE-cadherin and F-actin...
May 17, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29770353/quantification-of-bacterial-twitching-motility-in-dense-colonies-using-transmitted-light-microscopy-and-computational-image-analysis
#5
Benjamin Smith, Jianfang Li, Matteo Metruccio, Stephanie Wan, David Evans, Suzanne Fleiszig
A method was developed to allow the quantification and mapping of relative bacterial twitching motility in dense samples, where tracking of individual bacteria was not feasible. In this approach, movies of bacterial films were acquired using differential interference contrast microscopy (DIC), and bacterial motility was then indirectly quantified by the degree to which the bacteria modulated the intensity of light in the field-of-view over time. This allowed the mapping of areas of relatively high and low motility within a single field-of-view, and comparison of the total distribution of motility between samples...
April 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29759987/parental-desensitization-to-gun-violence-in-pg-13-movies
#6
Daniel Romer, Patrick E Jamieson, Kathleen Hall Jamieson, Robert Lull, Azeez Adebimpe
: media-1vid110.1542/5745216462001PEDS-VA_2017-3491 Video Abstract OBJECTIVE: To assess effects of justified versus unjustified screen violence on parents' willingness to allow children to view films that contain extensive gun violence. METHODS: A national US sample of 610 parents with at least 1 child between ages 6 and 17 was randomly assigned to view a series of four 90-second video clips from popular films depicting violent gun use under either justified or unjustified conditions...
May 14, 2018: Pediatrics
https://www.readbyqxmd.com/read/29757115/just-google-it-an-approach-on-word-frequencies-based-on-online-search-result
#7
Carmen Moret-Tatay, Daniel Gamermann, Michael Murphy, Anezka Kuzmičová
Word frequency is one of the most robust factors in the literature on word processing, based on the lexical corpus of a language. However, different sources might be used in order to determine the actual frequency of each word. Recent research has determined frequencies based on movie subtitles, Twitter, blog posts, or newspapers. In this paper, we examine a determination of these frequencies based on the World Wide Web. For this purpose, a Python script was developed to obtain frequencies of a word through online search results...
April 2018: Journal of General Psychology
https://www.readbyqxmd.com/read/29755744/enzyme-catalysis-captured-using-multiple-structures-from-one-crystal-at-varying-temperatures
#8
Sam Horrell, Demet Kekilli, Kakali Sen, Robin L Owen, Florian S N Dworkowski, Svetlana V Antonyuk, Thomas W Keal, Chin W Yong, Robert R Eady, S Samar Hasnain, Richard W Strange, Michael A Hough
High-resolution crystal structures of enzymes in relevant redox states have transformed our understanding of enzyme catalysis. Recent developments have demonstrated that X-rays can be used, via the generation of solvated electrons, to drive reactions in crystals at cryogenic temperatures (100 K) to generate 'structural movies' of enzyme reactions. However, a serious limitation at these temperatures is that protein conformational motion can be significantly supressed. Here, the recently developed MSOX (multiple serial structures from one crystal) approach has been applied to nitrite-bound copper nitrite reductase at room temperature and at 190 K, close to the glass transition...
May 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29753842/extracting-orthogonal-subject-and-condition-specific-signatures-from-fmri-data-using-whole-brain-effective-connectivity
#9
Vicente Pallarés, Andrea Insabato, Ana Sanjuán, Simone Kühn, Dante Mantini, Gustavo Deco, Matthieu Gilson
The study of brain communication based on fMRI data is often limited because such measurements are a mixture of session-to-session variability with subject- and condition-related information. Disentangling these contributions is crucial for real-life applications, in particular when only a few recording sessions are available. The present study aims to define a reliable standard for the extraction of multiple signatures from fMRI data, while verifying that they do not mix information about the different modalities (e...
May 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29746463/nonlinear-decoding-of-a-complex-movie-from-the-mammalian-retina
#10
Vicente Botella-Soler, Stéphane Deny, Georg Martius, Olivier Marre, Gašper Tkačik
Retina is a paradigmatic system for studying sensory encoding: the transformation of light into spiking activity of ganglion cells. The inverse problem, where stimulus is reconstructed from spikes, has received less attention, especially for complex stimuli that should be reconstructed "pixel-by-pixel". We recorded around a hundred neurons from a dense patch in a rat retina and decoded movies of multiple small randomly-moving discs. We constructed nonlinear (kernelized and neural network) decoders that improved significantly over linear results...
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29745914/weight-loss-in-a-young-patient-with-type-2-diabetes-challenges-of-diabetes-management-using-online-program-of-good-nutrition-case-report
#11
V Krylov
A 31-year-old male with a history of obesity, type 2 diabetes mellitus (T2DM) and hypercholesterolemia came to our clinic for medical weight-loss management. According to his initial anthropometric measurements (weight - 193 kg, height - 181 cm, and body mass index (BMI) - 58 kg/m2) patient had morbid obesity. In order to educate our patient about good nutrition, physical activity and the need of sun exposure we used an online system based on the video lessons, full of humor, pictures, and cartoons. Even one month of watching the short educational movies was sufficient for the patient to form the habits of healthy eating, including restriction of fat and digestible carbohydrates and increase in daily consumption of low-fat dairy products, slow carbohydrates, protein and fiber...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29744047/cinemedicine-using-movies-to-improve-students-understanding-of-psychosocial-aspects-of-medicine
#12
Maliheh Kadivar, Mahboobeh Khabaz Mafinejad, Javad Tavakkoly Bazzaz, Azim Mirzazadeh, Zeinab Jannat
Background: There are rising concerns about how to teach psychosocial aspects of medicine to students. The aim of the study was the use of "cinemedicine" as a tool and technique in teaching psychosocial aspects of medicine to medical students at Tehran University of Medical Sciences (TUMS). Methods: This was an educational study with quantitative and qualitative data analysis. Two hundred seventy medical students participated in this study. Nine sessions were held to teach psychosocial subjects in medicine using movies...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29742051/interaction-of-wdr60-intermediate-chain-with-tctex1d2-light-chain-of-the-dynein-2-complex-is-crucial-for-ciliary-protein-trafficking
#13
Yuki Hamada, Yuta Tsurumi, Shohei Nozaki, Yohei Katoh, Kazuhisa Nakayama
The dynein-2 complex mediates trafficking of ciliary proteins by powering the intraflagellar transport (IFT) machinery containing IFT-A and IFT-B complexes. Although 11 subunits are known to constitute the dynein-2 complex, with several light chain subunits shared by the dynein-1 complex, the overall architecture of the dynein-2 complex has not been fully clarified. Utilizing the visible immunoprecipitation assay, we demonstrated the interaction modes among the dynein-2 subunits, including previously undefined interactions, such as that between WDR60 and the TCTEX1D2-DYNLT1/DYNLT3 dimer...
May 9, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29741382/on-the-border-between-low-nuclearity-and-one-dimensional-solids-a-unique-interplay-of-1-2-4-triazolyl-based-cu-ii-5-oh-2-clusters-and-mo-vi-oxide-matrix
#14
Andrey B Lysenko, Oksana A Bondar, Ganna A Senchyk, Eduard B Rusanov, Monika Srebro-Hooper, James Hooper, Krunoslav Prsa, Karl W Krämer, Silvio Decurtins, Oliver Waldmann, Shi-Xia Liu
A pentanuclear CuII 5 -hydroxo cluster possessing an unusual linear-shaped configuration was formed and crystallized under hydrothermal conditions as a result of the unique cooperation of bridging 1,2,4-triazole ligand ( trans-1,4-cyclohexanediyl-4,4'-bi(1,2,4-triazole) ( tr2 cy)), MoVI -oxide, and CuSO4 . This structural motif can be rationalized by assuming in situ generation of {Cu2 Mo6 O22 }4- anions, which represent heteroleptic derivatives of γ-type [Mo8 O26 ]4- further interlinked by [Cu3 (OH)2 ]4+ cations through [ N- N] bridges...
May 9, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29740295/temporal-resolution-needed-for-auditory-communication-measurement-with-mosaic-speech
#15
Yoshitaka Nakajima, Mizuki Matsuda, Kazuo Ueda, Gerard B Remijn
Temporal resolution needed for Japanese speech communication was measured. A new experimental paradigm that can reflect the spectro-temporal resolution necessary for healthy listeners to perceive speech is introduced. As a first step, we report listeners' intelligibility scores of Japanese speech with a systematically degraded temporal resolution, so-called "mosaic speech": speech mosaicized in the coordinates of time and frequency. The results of two experiments show that mosaic speech cut into short static segments was almost perfectly intelligible with a temporal resolution of 40 ms or finer...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29736430/gunshot-wound-dynamics-model-for-john-f-kennedy-assassination
#16
Nicholas R Nalli
U.S. President John F. Kennedy was assassinated while riding in an open motorcade by a sniper in Dallas, Texas on 22 November 1963. A civilian bystander, Mr. Abraham Zapruder, filmed the motorcade with a 8-mm home movie camera as it drove through Dealey Plaza, inadvertently recording an ≈8 second sequence of events that included a fatal gunshot wound to the President in the head. The accompanying backward motion of the President's head after impact appeared to support later "conspiracy theories" because it was claimed that this was proof of a shot from the front (in addition to one from behind)...
April 2018: Heliyon
https://www.readbyqxmd.com/read/29735734/substrate-protein-dependence-of-groel-groes-interaction-cycle-revealed-by-high-speed-atomic-force-microscopy-imaging
#17
Daisuke Noshiro, Toshio Ando
A double-ring-shaped tetradecameric GroEL complex assists proper protein folding in cooperation with the cochaperonin GroES. The dynamic GroEL-GroES interaction reflects the allosteric intra- and inter-ring communications and the chaperonin reaction. Therefore, revealing this dynamic interaction is essential to understanding the allosteric communications and the operation mechanism of GroEL. Nevertheless, how this interaction proceeds in the chaperonin cycle has long been controversial. Here, we directly image the dynamic GroEL-GroES interaction under conditions with and without foldable substrate protein using high-speed atomic force microscopy...
June 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29728597/time-lapse-3d-imaging-by-positron-emission-tomography-of-cu-mobilized-in-a-soil-column-by-the-herbicide-mcpa
#18
Johannes Kulenkampff, Madeleine Stoll, Marion Gründig, Alexander Mansel, Johanna Lippmann-Pipke, Michael Kersten
Phenoxyalkanoic acids like the 4-chloro-2-methylphenoxyacetic acid (MCPA) are the second highest used xenobiotic herbicides worldwide after glyphosate because of their apparently favorable environmental properties. Experimental batch equilibration data suggested a reduced Cu adsorption efficiency with the soil mineral goethite below pH 6 in presence of MCPA. This has been verified by advanced surface complexation adsorption modelling involving dissolved Cu-MCPA complexation constants. Positron emission tomography is a non-invasive molecular imaging method for time-resolved three-dimensional information commonly applied on non-retarded tracers in soil core scale experiments...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29727895/in-vivo-axial-humero-ulnar-rotation-in-normal-and-dysplastic-canine-elbow-joints
#19
Thomas Rohwedder, Martin Fischer, Peter Böttcher
OBJECTIVE: To prospectively compare relative axial (internal-external) humero-ulnar rotation in normal and dysplastic canine elbow joints. MATERIAL AND METHODS: Six normal elbows (five dogs) and seven joints (six dogs) with coronoid disease were examined. After implantation of 0.8 mm tantalum beads into humerus and ulna, biplanar x-ray movies of the implanted elbows were taken while dogs were walking on a treadmill. Based on the 2D bead coordinates of the synchronized x-ray movies virtual 3D humero-ulnar animations were calculated...
April 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29718766/multi-compartment-cell-based-modeling-of-confined-migration-regulation-by-cell-intrinsic-and-extrinsic-factors
#20
Sandeep Kumar, Alakesh Das, Shamik Sen
Though cell and nuclear deformability are expected to influence efficiency of confined migration, their individual and collective influence on migration efficiency remains incompletely understood. In addition to cell intrinsic properties, the relevance of cell extrinsic factors on confined migration, if any, has not been adequately explored. Here, we address these questions using a statistical mechanics-based stochastic modeling approach where cell/nuclear dimensions and their deformability are explicitly taken into consideration...
May 2, 2018: Molecular Biology of the Cell
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