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https://www.readbyqxmd.com/read/28240006/effects-of-six-weeks-endurance-training-and-aloe-vera-supplementation-on-cox-2-and-vegf-levels-in-mice-with-breast-cancer
#1
Saeed Shirali, Alireza Barari, Seyed Ahmad Hosseini, Elaheh Khodadi
The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60 minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239983/targeted-deletion-of-gd3-synthase-protects-against-mptp-induced-neurodegeneration
#2
Yada Akkhawattanangkul, Panchanan Maiti, Yi Xue, Dipendra Aryal, William C Wetsel, David Hamilton, Stephen C Fowler, Michael P McDonald
Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown that interventions that simultaneously increase the neuroprotective GM1 ganglioside and decrease the pro-apoptotic GD3 ganglioside-such as inhibition of GD3 synthase (GD3S) or administration of sialidase-are neuroprotective in vitro and in a number of preclinical models...
February 27, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28239957/activating-transcription-factor-3-promotes-malignance-of-lung-cancer-cells-in-vitro
#3
Xuebing Li, Xuexia Zhou, Yongwen Li, Lingling Zu, Hongli Pan, Boning Liu, Wang Shen, Yaguang Fan, Qinghua Zhou
BACKGROUND: Lung cancer remains the most common cause of cancer-related death, with high rates of recurrence and poor outcomes. An abnormally high expression of activating transcription factor 3 (ATF3) in various cancers suggests an oncogenic role; however, its function in lung cancer is largely unknown. METHODS: Sixty-four pairs of lung cancer tissues were collected for ATF3 expression analysis by quantitative real-time PCR, immunoblotting, and immunohistochemistry staining...
February 27, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28239848/protein-phosphatase-2a-pp2a-regulation-of-markers-of-extracellular-matrix-remodelling-in-hcc-cells-functional-consequences-for-tumour-invasion
#4
M P Ward, J P Spiers
BACKGROUND AND PURPOSE: A hallmark of tumour invasion is breakdown of the extracellular matrix as a consequence of dysregulation of the MMP system. While our understanding of how this is regulated by kinase signalling pathways is well established, its counter-regulation by protein phosphatases is less well known. Therefore, we investigated the effect of inhibition of protein phosphatases on markers of extracellular remodelling and how PP2A modulates MMP-9 abundance and function of Hep3B cells...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239846/inhibition-of-6-phosphofructo-2-kinase-suppresses-fibroblast-like-synoviocytes-mediated-synovial-inflammation-and-joint-destruction-in-rheumatoid-arthritis
#5
Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu
BACKGROUND AND PURPOSE: Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls the glycolytic rate, in regulating fibroblast-like synoviocyte (FLS)-mediated synovial inflammation and invasiveness in RA. EXPERIMENTAL APPROACH: A specific PFKFB3 inhibitor, PFK15, and siRNA were used to evaluate the role of PFKFB3...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239845/stimulation-of-na-k-pump-currents-by-epithelial-nicotinic-receptors-in-rat-colon
#6
Sandra Bader, Lena Lottig, Martin Diener
BACKGROUND AND PURPOSE: Acetylcholine-induced epithelial Cl(-) secretion is generally thought to be mediated by epithelial muscarinic receptors and nicotinic receptors on secretomotor neurons. However, recent data showed the expression of nicotinic receptors by intestinal epithelium and the stimulation of Cl(-) secretion by nicotine in the presence of the neurotoxin, tetrodotoxin. In the present study, we aimed to identify the transporters activated by epithelial nicotinic receptors and to clarify their role in cholinergic regulation of intestinal ion transport...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239825/upregulated-serum-sclerostin-level-in-the-t2dm-patients-with-femur-fracture-inhibits-the-expression-of-bone-formation-remodeling-associated-biomarkers-via-antagonizing-wnt-signaling
#7
Y Wu, S-Y Xu, S-Y Liu, L Xu, S-Y Deng, Y-B He, S-C Xian, Y-H Liu, G-X Ni
OBJECTIVE: Bone formation/remodeling-associated biomarkers, such as osteocalcin, amino pro-peptide of type 1 collagen (P1NP) and CrossLaps (CTX) have been deregulated in type 2 diabetes mellitus (T2DM) patients. In particular, the T2DM-associated sclerostin markedly inhibits the bone formation, suppresses the osteoblast activity and downregulates the bone turnover. PATIENTS AND METHODS: In the present study, we examined the serum levels of sclerostin, osteocalcin, P1NP and CTX in the T2DM patients...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239823/inhibitory-effect-and-mechanism-of-metformin-on-human-ovarian-cancer-cells-skov-3-and-a2780
#8
J Huo, X-H Bian, Y Huang, Z-C Miao, L-H Song
OBJECTIVE: Ovarian cancer is the most common malignant tumor in female reproductive system. Metformin is an orally taken hypoglycemic agent, which is extensively applied in the clinic. Clinical trials find that there may be a certain degree of action of the metformin in inhibiting malignant tumors. This paper aims to investigate the inhibitory effect and mechanism of metformin on human ovarian cancer cells. MATERIALS AND METHODS: Through in vitro cell experiment, the influences of metformin on the proliferation, colony formation and apoptosis of ovarian carcinoma cells were studied...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239822/the-relationship-between-the-expression-of-tam-survivin-and-the-degree-of-necrosis-of-the-tumor-after-cisplatin-treatment-in-osteosarcoma
#9
G Chen
OBJECTIVE: To explore the relationship between the expression of TAM, survivin and the degree of necrosis of the tumor after cisplatin treatment in osteosarcoma. MATERIALS AND METHODS: The mice model of osteosarcoma S180 were injected with 6 mg/kg/day of cisplatin (observation group) or the same amount of normal saline (control group) for 4 weeks. Mice were sacrificed at days 1, 4, 9, 14, 18, 22 and 28, respectively, 24 h before administration of the drug or saline, and tumor tissues were collected...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239820/long-non-coding-rna-neat1-acts-as-oncogene-in-nsclc-by-regulating-the-wnt-signaling-pathway
#10
S-J Sun, Q Lin, J-X Ma, W-W Shi, B Yang, F Li
OBJECTIVE: The present study aimed to explore the role of long non-coding RNA NEAT1 (NEAT1) in mediating non-small cell lung cancer (NSCLC) cell migration and invasion, as well as the underlying regulatory mechanisms. PATIENTS AND METHODS: The NEAT1 expression in NSCLC tissues and cell lines was measured using reverse transcription‑quantitative polymerase chain reaction (RT-qPCR). The relationships between NEAT1 expression and clinicopathological parameters were examined by chi-square test...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239819/mir-137-and-its-target-tgfa-modulate-cell-growth-and-tumorigenesis-of-non-small-cell-lung-cancer
#11
X Liu, L Chen, X-D Tian, T Zhang
OBJECTIVE: MiR-137 has been reported to serve as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the potential mechanism remains largely unclear. The present study aimed to explore the potential molecular mechanisms by which miR-137 regulated NSCLC. MATERIALS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to quantify the expression levels of miR-137 in NSCLC tissues and cell lines. Dual-luciferase reporter assay was employed to confirm the specificity of miR-137 target genes...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239814/microrna15b-induced-smcc7721-apoptosis-via-down-regulation-of-xiap
#12
W-B Ding, Y-X Wang, C-W Dong
OBJECTIVE: microRNA can regulate cell growth, proliferation, and death; also, it can promote or inhibit cell growth and proliferation through regulation of apoptotic proteins. XIAP is a newly discovered pro-apoptotic protein, but how is XIAP regulated remains unclear. This study investigated the role of microRNA-15b in liver cancer cells' proliferation and apoptosis. MATERIALS AND METHODS: microRNA15b and control microRNA (miRNA) were purchased and transfected with hepatoma SMCC7721 cells using liposomal transfection techniques...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239806/mechanism-of-action-of-kiaa1456-gene-on-the-proliferation-and-apoptosis-of-alveolar-epithelial-cells
#13
S-L Wang, J-A Huang, X-Q Liu
OBJECTIVE: To explore the mechanism by which KIAA1456 acts on alveolar epithelial cells through lentiviral transfection. MATERIALS AND METHODS: After constructing a KIAA1456 gene vector, 293T cells were co-transfected with lentiviral vectors and after incubation cells were examined by fluorescence microscopy. CCL-149 cells were transfected with LV-KIAA1456 and were examined by fluorescence microscopy. The proliferation capacity of transfected CCL-149 cells was evaluated using flow cytometry...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239782/inhibition-of-klebsiella-pneumoniae-growth-by-selected-australian-plants-natural-approaches-for-the-prevention-and-management-of-ankylosing-spondylitis
#14
V Winnett, J Sirdaarta, A White, F M Clarke, I E Cock
A wide variety of herbal remedies are used in traditional Australian medicine to treat inflammatory disorders, including autoimmune inflammatory diseases. One hundred and six extracts from 40 native Australian plant species traditionally used for the treatment of inflammation and/or to inhibit bacterial growth were investigated for their ability to inhibit the growth of a microbial trigger for ankylosing spondylitis (K. pneumoniae). Eighty-six of the extracts (81.1%) inhibited the growth of K. pneumoniae. The D...
February 27, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28239766/up-regulation-of-gbp2-is-associated-with-neuronal-apoptosis-in-rat-brain-cortex-following-traumatic-brain-injury
#15
Qi Miao, Meihong Ge, Lili Huang
Guanylate binding protein 2 (GBP2) is one member of GBP family. Recently, GBP2 has been proposed to be a novel target of anti-cancer drugs. However, the role of GBP2 in the traumatic brain injury (TBI) is very limited. In this study, we sought to define GBP2's role in brain injury. GBP2 protein levels were significantly increased in the brain 3 days after injury, suggesting a functional role for GBP2 in TBI. Neuronal cells overexpressing GBP2 exhibited up-regulation of co-location of GBP2 and NeuN following TBI, suggesting that GBP2 potentiates the neuron apoptosis...
February 27, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28239749/interleukin-21-inhibits-cancer-mediated-foxp3-induction-in-na%C3%A3-ve-human-cd4-t-cells
#16
Vinodh Kannappan, Kate Butcher, Malgorzata Trela, Iain Nicholl, Weiguang Wang, Kesley Attridge
IL-21 is known to promote anti-tumour immunity due to its ability to promote T cell responses and counteract Treg-mediated suppression. It has also been shown to limit Treg frequencies during tumour-antigen stimulations. However, whether this represents inhibition of FOXP3 induction in naïve CD4 T cells or curtailed expansion of natural Treg remains unclear. Moreover, whether this effect is maintained in an environment of tumour-derived immunosuppressive factors is not known. Here, we show that in the context of a number of cancers, naïve CD45RA+ CD4 T cells are induced to express high levels of FOXP3, and that FOXP3 expression correlates with inhibition of T cell proliferation...
February 27, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28239746/induction-of-sa-signaling-pathway-and-ethylene-biosynthesis-in-trichoderma-harzianum-treated-tomato-plants-after-infection-of-the-root-knot-nematode-meloidogyne-incognita
#17
Paola Leonetti, Maria Chiara Zonno, Sergio Molinari, Claudio Altomare
Salicylic acid-signaling pathway and ethylene biosynthesis were induced in tomato treated with Trichoderma harzianum when infected by root-knot nematodes and limited the infection by activation of SAR and ethylene production. Soil pre-treatment with Trichoderma harzianum (Th) strains ITEM 908 (T908) and T908-5 decreased susceptibility of tomato to Meloidogyne incognita, as assessed by restriction in nematode reproduction and development. The effect of T. harzianum treatments on plant defense was detected by monitoring the expression of the genes PR-1/PR-5 and JERF3/ACO, markers of the SA- and JA/ET-dependent signaling pathways, respectively...
February 26, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28239742/the-role-of-the-sdf-1-cxcr7-axis-on-the-growth-and-invasion-ability-of-endometrial-cancer-cells
#18
Hong-Qin Gu, Zhen-Bo Zhang, Jia-Wen Zhang, Qian-Qian Wang, Xiao-Wei Xi, Yin-Yan He
PURPOSE: Stroma-derived factor-1 (SDF-1) and its receptor C-X-C chemokine receptor-4 (CXCR4) are involved in human endometrial carcinoma (EC) progression. CXCR7 is another important receptor of SDF-1 and has a higher affinity with SDF-1 compared with that of CXCR4. This paper aims to study the effects of the SDF-1/CXCR7 axis on the growth and invasion ability of EC cells. METHODS: CXCR7 expression was evaluated by quantitative RT-PCR, immunohistochemistry, immunocytochemistry and Western blotting in EC cell lines and 30 cases of primary EC tissue from patients...
February 27, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28239720/superwetting-comonomers-reduce-adhesion-of-e-coli-bl21
#19
Madiha F Khan, Nicholas Luong, Jerry Kurian, Michael A Brook
The adhesion of Escherichia coli to copolymers of methacrylates and a trisiloxane-polyether acrylate surfactant was found to be at a minimum with copolymers containing a low (20%) fraction of the surfactant monomer. Rather than wettability, hardness, or water uptake, adhesion was found to be limited by the presence of low concentrations of bound surfactant that can interact with hydrophobic domains on the bacterium inhibiting anchoring to the polymer surface.
February 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28239687/protein-phosphatase-5-contributes-to-the-overexpression-of-epigenetically-regulated-t-lymphocyte-genes-in-patients-with-lupus
#20
D Patel, G Gorelik, B Richardson
OBJECTIVE: Lupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by the exogenous stressors. Current evidence indicates that these environmental agents can trigger lupus flares by inhibiting the replication of DNA methylation patterns during mitosis in CD4(+) T cells, altering the expression of genes suppressed by this mechanism that convert normal "helper" cells into auto reactive cells which promote lupus flares...
December 2016: Lupus (Los Angel)
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