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https://www.readbyqxmd.com/read/29160572/rapid-on-site-evaluation-of-routine-biochemical-parameters-to-predict-right-ventricular-dysfunction-in-and-the-prognosis-of-patients-with-acute-pulmonary-embolism-upon-admission-to-the-emergency-room
#1
Dong Jia, Fan Liu, Qin Zhang, Guang-Qiao Zeng, Xue-Lian Li, Gang Hou
INTRODUCTION: Patients with acute pulmonary embolism(APE)who present with right ventricular dysfunction (RVD) have a worse prognosis. This study aimed to evaluate the value of routine biochemical parameters in predicting RVD and 30-day mortality in patients with APE. METHODS: We retrospectively collected the clinical data for 154 enrolled patients, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), D-dimer, cardiac troponin I (cTnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP)...
November 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29154970/patient-engagement-using-new-technology-to-improve-adherence-to-positive-airway-pressure-therapy-a-retrospective-analysis
#2
Atul Malhotra, Maureen E Crocker, Leslee Willes, Colleen Kelly, Sue Lynch, Adam V Benjafield
BACKGROUND: Sleep apnea has major neurocognitive and cardiovascular and metabolic risks. Treatment of sleep apnea is sub-optimal because of variable adherence to existing therapies. METHODS: This trial compared PAP adherence among patients who were provided active patient engagement (APE) technology versus those who received usual care monitoring (UCM). The primary outcome was defined by the U.S. Medicare definition of adherence. PARTICIPANTS: Adherence data from two cloud-based databases (AirView™ and myAir™) were analyzed for patients with sleep apnea...
November 15, 2017: Chest
https://www.readbyqxmd.com/read/29154098/generation-and-application-of-a-novel-transgenic-zebrafish-line-tg-cyp1a-mcherry-as-an-in-vivo-assay-to-sensitively-monitor-pahs-and-tcdd-in-the-environment
#3
Shao-Lin Xie, Muhammad Junaid, Wan-Ping Bian, Juan-Juan Luo, Jabir Hussain Syed, Chao Wang, Wen-Xu Xiong, Yan-Bo Ma, Aping Niu, Xiao-Jun Yang, Ji-Xing Zou, De-Sheng Pei
The polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) are classified as human carcinogens, and can also cause serious health problems. To develop a convenient bio-monitoring tool for the detection of PAHs and TCDD in the environment, we generated a transgenic zebrafish line Tg(cyp1a:mCherry) with cyp1a promoter driving mCherry expression. Here, Tg(cyp1a:mCherry) embryos were treated with different concentrations of TCDD and five US EPA priority PAHs congeners. The results showed that the expressions of mCherry and endogenous cyp1a were consistent with the PAHs exposure concentrations and were largely induced by TCDD and ≥4-ring PAHs...
November 13, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29151532/association-of-admission-glucose-level-and-improvement-in-pulmonary-artery-pressure-in-patients-with-submassive-type-acute-pulmonary-embolism
#4
Masaomi Gohbara, Keigo Hayakawa, Azusa Hayakawa, Yusuke Akazawa, Yukihiro Yamaguchi, Shuta Furihata, Ai Kondo, Yusuke Fukushima, Sakie Tomari, Takayuki Mitsuhashi, Tsutomu Endo, Kazuo Kimura
Objective The admission glucose level is a predictor of mortality even in patients with acute pulmonary embolism (APE). However, whether or not the admission glucose level is associated with the severity of APE itself or the underlying disease of APE is unclear. Methods This study was a retrospective observational study. A pulmonary artery (PA) catheter was used to accurately evaluate the severity of APE. The percentage changes in the mean PA pressure (PAPm) upon placement and removal of the inferior vena cava filter (IVCF) were evaluated...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29150813/a-social-cichlid-fish-failed-to-pass-the-mark-test
#5
Takashi Hotta, Shiho Komiyama, Masanori Kohda
Since the pioneering work in chimpanzees, mirror self-recognition (MSR), the ability to recognise oneself in a mirror, has been reported in great apes, Asian elephants, dolphins, and some social birds using the mark test, in which animals that possess MSR touch an imperceptible mark on their own bodies only when a mirror is present. However, giant pandas, which are solitary, failed to pass the mark test, suggesting that MSR evolved solely in highly social animals. In contrast to the increasing evidence of MSR in mammals and birds, little is known about MSR in fish...
November 17, 2017: Animal Cognition
https://www.readbyqxmd.com/read/29146419/syncope-on-presentation-is-a-surrogate-for-submassive-and-massive-acute-pulmonary-embolism
#6
Hesham R Omar, Mehdi Mirsaeidi, Michael B Weinstock, Garett Enten, Devanand Mangar, Enrico M Camporesi
INTRODUCTION: There are conflicting data regarding the prognostic value of syncope in patients with acute pulmonary embolism (APE). METHODS: We retrospectively reviewed data of 552 consecutive adults with computed tomography pulmonary angiogram-confirmed APE to determine the correlates and outcome of the occurrence of syncope at the time of presentation. RESULTS: Among 552 subjects with APE (mean age 54years, 47% men), syncope occurred in 12...
November 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29144567/reliable-recognition-of-lying-sitting-and-standing-with-a-hip-worn-accelerometer
#7
Henri Vähä-Ypyä, Pauliina Husu, Jaana Suni, Tommi Vasankari, Harri Sievänen
Hip-worn accelerometers are widely used to estimate physical activity (PA), but the accuracy of acceleration-threshold based analysis is compromised when it comes to identifying stationary and sedentary behaviors, let alone classifying body postures into lying, sitting or standing. The purpose of this study was to devise a novel method for accurate classification of body posture using triaxial data from hip-worn accelerometer and to evaluate its performance in free-living conditions against a thigh-worn accelerometer...
November 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29140072/novel-aerosol-phase-extraction-method-for-the-determination-of-ca-k-mg-and-na-in-biodiesel-through-inductively-coupled-plasma-atomic-emission-spectrometry
#8
Raquel Sanchez, Salvador Maestre, Maria Soledad Prats Moya, José Luis Todoli
A novel extraction method was developed, optimized and validated for the elemental analysis of organic samples. The method, called aerosol phase extraction (APE), was based on the nebulization of the extracting aqueous solution (0.1 mol L-1 nitric acid) on the sample. The extraction was performed at the interface of each generated extractant droplets as they entered in contact with the samples. Afterwards, the phases were allowed to separate and Ca, K, Na and Mg were determined in aqueous phase by means of inductively coupled plasma optical emission spectroscopy (ICP-OES)...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29136210/the-effect-of-sexual-maturity-and-egg-production-on-skeletal-muscle-pectoralis-major-and-gastrocnemius-protein-turnover-in-broiler-breeder-pure-lines
#9
Karen Vignale, Justina V Caldas, Judy A England, Nirun Boonsinchai, Phiphob Sodsee, Erik D Pollock, Craig N Coon
A study was conducted to evaluate the effect of sexual maturity on pectoralis major and gastrocnemius muscle protein turnover in broiler breeder pure lines. Protein turnover in skeletal muscle tissue was determined in 4 broiler breeder pure lines (Line A, Line B, Line C and Line D) at 22, 27, 33, 37, 44, and 50 wk of age. A completely randomized design with a factorial arrangement 4 × 6 (4 lines and 6 time periods (ages)) was used. There were 5 replicates per line/time and each hen represented a replicate...
November 9, 2017: Poultry Science
https://www.readbyqxmd.com/read/29134435/plant-phenology-supports-the-multi-emergence-hypothesis-for-ebola-spillover-events
#10
Katharina C Wollenberg Valero, Raphael D Isokpehi, Noah E Douglas, Seenith Sivasundaram, Brianna Johnson, Kiara Wootson, Ayana McGill
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of natural hosts and are unstable once outside hosts. Spillover events, which involve the physical transfer of viral particles across species, could therefore be directly promoted by conditions of host ecology and environment. In this report, we outline a proof of concept that temporal fluctuations of a set of ecological and environmental variables describing the dynamics of the host ecosystem are able to predict such events of Ebola virus spillover to humans and animals...
November 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29126243/faster-evolving-primate-genes-are-more-likely-to-duplicate
#11
Áine N O'Toole, Laurence D Hurst, Aoife McLysaght
An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent support was found in numerous analyses, particularly the observation of higher rates of evolution in duplicated as compared to singleton genes. Could it, instead, be that more duplicable genes (owing to mutation, fixation or retention biases) are intrinsically faster evolving? To uncouple the measurement of rates of evolution from the determination of duplicate or singleton status, we measure the rates of evolution in singleton genes in outgroup primate lineages but classify these genes as to whether they have duplicated or not in a crown group of great apes...
November 7, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29116455/do-habituation-host-traits-and-seasonality-have-an-impact-on-protist-and-helminth-infections-of-wild-western-lowland-gorillas
#12
Barbora Pafčo, Julio A Benavides, Ilona Pšenková-Profousová, David Modrý, Barbora Červená, Kathryn A Shutt, Hideo Hasegawa, Terence Fuh, Angelique F Todd, Klára J Petrželková
Increased anthropogenic activity can result in parasite exchanges and/or general changes in parasite communities, imposing a health risk to great apes. We studied protist and helminth parasites of wild western lowland gorilla groups in different levels of habituation, alongside humans inhabiting Dzanga-Sangha Protected Areas in the Central African Republic. Faeces were collected yearly during November and December from 2007 to 2010 and monthly from November 2010 to October 2011. Protist and helminth infections were compared among gorilla groups habituated, under habituation and unhabituated, and the effect of host traits and seasonality was evaluated...
December 2017: Parasitology Research
https://www.readbyqxmd.com/read/29115972/plasmodium-reichenowi-eba-140-merozoite-ligand-binds-to-glycophorin-d-on-chimpanzee-red-blood-cells-shedding-new-light-on-origins-of-plasmodium-falciparum
#13
Agata Zerka, Radoslaw Kaczmarek, Marcin Czerwinski, Ewa Jaskiewicz
BACKGROUND: All symptoms of malaria are caused by the intraerythrocytic proliferation of Plasmodium merozoites. Merozoites invade erythrocytes using multiple binding ligands that recognise specific surface receptors. It has been suggested that adaptation of Plasmodium parasites to infect specific hosts is driven by changes in genes encoding Plasmodium erythrocyte-binding ligands (EBL) and reticulocyte-binding ligands (RBL). Homologs of both EBL and RBL, including the EBA-140 merozoite ligand, have been identified in P...
November 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29109465/evidence-for-human-streptococcus-pneumoniae-in-wild-and-captive-chimpanzees-a-potential-threat-to-wild-populations
#14
Sophie Köndgen, Sebastien Calvignac-Spencer, Kim Grützmacher, Verena Keil, Kerstin Mätz-Rensing, Kathrin Nowak, Sonja Metzger, John Kiyang, Antina Lübke Becker, Tobias Deschner, Roman M Wittig, Felix Lankester, Fabian H Leendertz
Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29103940/morphometric-behavioral-and-genomic-evidence-for-a-new-orangutan-species
#15
Alexander Nater, Maja P Mattle-Greminger, Anton Nurcahyo, Matthew G Nowak, Marc de Manuel, Tariq Desai, Colin Groves, Marc Pybus, Tugce Bilgin Sonay, Christian Roos, Adriano R Lameira, Serge A Wich, James Askew, Marina Davila-Ross, Gabriella Fredriksson, Guillem de Valles, Ferran Casals, Javier Prado-Martinez, Benoit Goossens, Ernst J Verschoor, Kristin S Warren, Ian Singleton, David A Marques, Joko Pamungkas, Dyah Perwitasari-Farajallah, Puji Rianti, Augustine Tuuga, Ivo G Gut, Marta Gut, Pablo Orozco-terWengel, Carel P van Schaik, Jaume Bertranpetit, Maria Anisimova, Aylwyn Scally, Tomas Marques-Bonet, Erik Meijaard, Michael Krützen
Six extant species of non-human great apes are currently recognized: Sumatran and Bornean orangutans, eastern and western gorillas, and chimpanzees and bonobos [1]. However, large gaps remain in our knowledge of fine-scale variation in hominoid morphology, behavior, and genetics, and aspects of great ape taxonomy remain in flux. This is particularly true for orangutans (genus: Pongo), the only Asian great apes and phylogenetically our most distant relatives among extant hominids [1]. Designation of Bornean and Sumatran orangutans, P...
November 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29098692/ontogeny-of-hallucal-metatarsal-rigidity-and-shape-in-the-rhesus-monkey-macaca-mulatta-and-chimpanzee-pan-troglodytes
#16
Biren A Patel, Jason M Organ, Tea Jashashvili, Stephanie H Bui, Holly M Dunsworth
Life history variables including the timing of locomotor independence, along with changes in preferred locomotor behaviors and substrate use during development, influence how primates use their feet throughout ontogeny. Changes in foot function during development, in particular the nature of how the hallux is used in grasping, can lead to different structural changes in foot bones. To test this hypothesis, metatarsal midshaft rigidity [estimated from the polar second moment of area (J) scaled to bone length] and cross-sectional shape (calculated from the ratio of maximum and minimum second moments of area, Imax /Imin ) were examined in a cross-sectional ontogenetic sample of rhesus macaques (Macaca mulatta; n = 73) and common chimpanzees (Pan troglodytes; n = 79)...
November 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29097524/new-ape-found-sparking-fears-for-its-survival
#17
Erik Stokstad
No abstract text is available yet for this article.
November 3, 2017: Science
https://www.readbyqxmd.com/read/29095520/the-grand-challenge-of-great-ape-health-and-conservation-in-the-anthropocene
#18
Dominic A Travis, Elizabeth V Lonsorf, Thomas R Gillespie
"Ecosystem Health recognizes the inherent interdependence of the health of humans, animals and ecosystems and explores the perspectives, theories and methodologies emerging at the interface between ecological and health sciences." This broad focus requires new approaches and methods for solving problems of greater complexity at larger scales than ever before. Nowhere is this point more salient than the case of disease emergence and control at the human-non human primate interface in shrinking tropical forests under great anthropogenic pressure...
November 2, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/29095265/identification-of-differential-expressed-pe-exosomal-mirna-in-lung-adenocarcinoma-tuberculosis-and-other-benign-lesions
#19
Yan Wang, Yan-Mei Xu, Ye-Qing Zou, Jin Lin, Bo Huang, Jing Liu, Jing Li, Jing Zhang, Wei-Ming Yang, Qing-Hua Min, Shu-Qi Li, Qiu-Fang Gao, Fan Sun, Qing-Gen Chen, Lei Zhang, Yu-Huan Jiang, Li-Bin Deng, Xiao-Zhong Wang
Pleural effusion (PE) is a common clinical complication of many pulmonary and systemic diseases, including lung cancer and tuberculosis. Nevertheless, there is no clinical effective biomarker to identify the cause of PE. We attempted to investigate differential expressed exosomal miRNAs in PEs of lung adenocarcinoma (APE), tuberculous (TPE), and other benign lesions (NPE) by using deep sequencing and quantitative polymerase chain reaction (qRT-PCR). As a result, 171 differentiated miRNAs were observed in 3 groups of PEs, and 11 significantly differentiated exosomal miRNAs were validated by qRT-PCR...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29081820/antihypercholesterolemic-effects-of-fruit-aqueous-extract-of-copernicia-prunifera-miller-h-e-moore-in-mice-diet-induced-hypercholesterolemia
#20
Raquel Teixeira Terceiro Paim, Stephen Rathinaraj Benjamin, Davide Rondina, Márcia Maria Mendes Marques, Daniel de Araújo Viana, Maria Leônia da Costa Gonzaga, Ícaro Gusmão Pinto Vieira, Francisca Noélia Pereira Mendes, Paula Alves Salmito Rodrigues, Maria Izabel Florindo Guedes
The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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