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https://www.readbyqxmd.com/read/28724795/alx-receptor-ligands-define-a-biochemical-endotype-for-severe-asthma
#1
Isabell Ricklefs, Ioanna Barkas, Melody G Duvall, Manuela Cernadas, Nicole L Grossman, Elliot Israel, Eugene R Bleecker, Mario Castro, Serpil C Erzurum, John V Fahy, Benjamin M Gaston, Loren C Denlinger, David T Mauger, Sally E Wenzel, Suzy A Comhair, Andrea M Coverstone, Merritt L Fajt, Annette T Hastie, Mats W Johansson, Michael C Peters, Brenda R Phillips, Bruce D Levy
BACKGROUND: In health, inflammation resolution is an active process governed by specialized proresolving mediators and receptors. ALX/FPR2 receptors (ALX) are targeted by both proresolving and proinflammatory ligands for opposing signaling events, suggesting pivotal roles for ALX in the fate of inflammatory responses. Here, we determined if ALX expression and ligands were linked to severe asthma (SA). METHODS: ALX expression and levels of proresolving ligands (lipoxin A4 [LXA4], 15-epi-LXA4, and annexin A1 [ANXA1]), and a proinflammatory ligand (serum amyloid A [SAA]) were measured in bronchoscopy samples collected in Severe Asthma Research Program-3 (SA [n = 69], non-SA [NSA, n = 51] or healthy donors [HDs, n = 47])...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28720527/usefulness-of-percutaneous-endoscopic-lumbar-foraminoplasty-for-lumbar-disc-herniation
#2
Kyung-Chul Choi, Hyeong-Ki Shim, Chan Jin Park, Dong Chan Lee, Choon-Keun Park
OBJECTIVE: Endoscopic foraminoplasty facilitates the engagement of the working cannula via the intervertebral foramen, allowing cannula access near the herniated disc (HD) for the successful application of percutaneous endoscopic lumbar discectomy (PELD). The purpose of this study was to evaluate the efficacy of foraminoplasty for HD and propose applicable situations for foraminoplasty in PELD. METHODS: A retrospective review of consecutive patients who underwent PELD was performed...
July 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28708496/comparative-evaluation-of-haematological-parameters-and-erythrocyte-membrane-stability-in-pregnant-and-lactating-goats-in-different-seasons-of-tropical-savannah
#3
B Habibu, H J Makun, L S Yaqub, H U Buhari, T Aluwong, M U Kawu
Haematological parameters and erythrocyte osmotic fragility (EOF) are commonly used as indicators of health status and erythrocyte membrane integrity. Variations in haematological parameters and EOF in late gestation and early lactation during the cold-dry (CDS), hot-dry (HDS) and rainy (RAS) seasons were studied in sixty (n = 60) Red Sokoto goats (20 goats for each season). The ambient temperatures and temperature-humidity index recorded were higher in the afternoon hours of the HDS and RAS, but lower in the morning hours of the CDS as compared with the thermoneutral zone of goats...
September 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28694622/pulmonary-involvement-in-patients-with-guillain-barr%C3%A3-syndrome-in-subacute-phase
#4
Meeka Khanna, Nidhi Rawat, Anupam Gupta, Madhu Nagappa, Arun B Taly, M R Rukmani, T N Sathyaprabha, Partha Haldar
OBJECTIVES: To evaluate the pulmonary function in Guillain-Barre syndrome (GBS) patients in subacute phase and find clinical correlates of pulmonary dysfunction. METHODS: This was a single-center, prospective, cross-sectional, hospital-based study in GBS patients performed in Department of Neurological Rehabilitation at a tertiary care institute. Clinical examination for pulmonary function was done by measuring chest expansion. The pulmonary function tests were carried out by Spirometry kit Microquark Cosmed, Italy...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28679857/challenges-in-the-medical-management-of-symptomatic-intracranial-stenosis-in-an-urban-setting
#5
Rajbeer S Sangha, Andrew M Naidech, Carlos Corado, Sameer A Ansari, Shyam Prabhakaran
BACKGROUND AND PURPOSE: Since the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), aggressive medical management (AMM), which includes dual antiplatelet therapy (DAPT) and high-dose statin (HDS) therapy, is recommended for patients with symptomatic intracranial atherosclerotic disease. However, limited data on the real-world application of this regimen exist. We hypothesized that recurrent stroke risk among patients treated with AMM is similar to the medical arm of the SAMMPRIS cohort...
July 5, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28677257/33s-label-tracing-for-hydrodesulfurization-process-insights-into-the-reaction-mechanism-catalyst-characterization-and-improvement
#6
Vitaly L Sushkevich, Andrey G Popov, Irina I Ivanova
The novel approach based on 33S label tracing is proposed for the elucidation of hydrodesulfurization (HDS) mechanisms and characterization of molybdenum sulfide catalysts. The technique involves sulfidation of the catalyst with dihydrogen sulfide labeled with the 33S isotope, followed by monitoring the fate of 33S label in the course of hydrodesulfurization reaction by on-line mass spectrometry and characterization of the catalyst after the reaction by TPO-MS. The results point to different pathways of thiophene transformation over Co or Ni promoted and unpromoted molybdenum sulfide catalysts, provide information on the role of promoter and give a key for the design of new efficient HDS catalysts...
July 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28650500/insight-into-thiophene-hydrodesulfurization-on-clean-and-s-modified-mop-010-a-periodic-density-functional-theory-study
#7
Guixia Li, Lianming Zhao, Houyu Zhu, Xiuping Liu, Huifang Ma, Yanchen Yu, Wenyue Guo
The hydrodesulfurization (HDS) of thiophene on clean and S-modified MoP(010) is investigated to understand the HDS mechanism as well as the surface sulfur (S) atom effect using periodic density functional theory (DFT). The results show that thiophene prefers strongly flat adsorption on both the clean and S-modified surfaces, in either the molecular state or the dissociative state breaking simultaneously one C-S bond, and the adsorption of thiophene can be slightly weakened by the surface S atom. Thermodynamic and kinetic analysis indicates that the HDS of thiophene in both the molecular and dissociative adsorption states prefers to take place along the direct desulfurization (DDS) pathway rather than hydrogenation on both the clean and S-modified MoP(010) surfaces...
June 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28626259/lao-language-version-of-the-revised-hasegawa-s-dementia-scale
#8
Sengchanh Kounnavong, Khouanchay Soundavong, Syda Xayavong, Nialoun Vongpraserth, Phongsavang Bounsavath, Souphatsone Houatthongkham, Bounfeng Phoummalaysith, Yu Mon Saw, Eiko Yamamoto, Kenji Toba, Nobuyuki Hamajima
With the aging of society, the number of elderly with reduced cognitive function has been increasing worldwide. As a test to measure the cognitive function, the Revised Hasegawa's Dementia Scale (HDS-R) has been used in Japan, Korea, and China. Since there was no HDS-R version for Laotians, the questionnaire and manual were developed through the cooperation of Lao and Japanese researchers. Back-translation was conducted to confirm the accuracy of the translation. The score on the 9-item HDS-R ranges 0 to 30 points, and reduced cognitive function is usually defined as a score of 20 points or lower...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28611660/neurodegeneration-and-the-circadian-clock
#9
REVIEW
Suzanne Hood, Shimon Amir
Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical activities (e.g., antioxidant production). Circadian disturbances are among the earliest symptoms of these diseases, and the molecular mechanisms of the circadian system are suspected to play a pivotal, and possibly causal, role in their natural histories...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28592739/a-case-of-idiopathic-normal-pressure-hydrocephalus-in-an-elder-diabetic-patient
#10
Kyoko Kawakami, Hiroshi Yoshino, Hiroyuki Igarashi, Yoshiyuki Chiba, Gen Yoshino, Takahisa Hirose
The clinical entity idiopathic normal pressure hydrocephalus (iNPH) is characterized by dementia, urinary incontinence, gait ataxia. An 80-year old man with a past history of Type 2 diabetes mellitus admitted to our hospital. Combination of twice Aspart and Aspart premixed30/70 insulin were used. Although, he was unable to inject insulin by himself recently. On physical examination, he walked in a mildly wide based manner. According to his family, urinary incontinence was existed. Laboratory data were as follows: Postrandial blood glucose 243 mg/dl and glycated hemoglobin 8...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28579128/the-role-of-hunger-state-and-dieting-history-in-neural-response-to-food-cues-an-event-related-potential-study
#11
Emily H Feig, Samantha R Winter, John Kounios, Brian Erickson, Staci A Berkowitz, Michael R Lowe
A history of dieting to lose weight has been shown to be a robust predictor of future weight gain. A potential factor in propensity towards weight gain is the nature of people's reactions to the abundance of highly palatable food cues in the environment. Event Related Potentials (ERPs) have revealed differences in how the brain processes food cues between obese and normal weight individuals, as well as between restrained and unrestrained eaters. However, comparisons by weight status are not informative regarding whether differences predate or follow weight gain in obese individuals and restrained eating has not consistently been found to predict future weight gain...
June 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28574487/cd123-target-validation-and-preclinical-evaluation-of-adcc-activity-of-anti-cd123-antibody-csl362-in-combination-with-nks-from-aml-patients-in-remission
#12
L H Xie, M Biondo, S J Busfield, A Arruda, X Yang, G Vairo, M D Minden
Despite the heterogeneity of acute myeloid leukemia (AML), overexpression of the interleukin-3 receptor-α (CD123) on both the more differentiated leukemic blast and leukemic stem cells (LSCs) provides a therapeutic target for antibody treatment. Here we present data on the potential clinical activity of the monoclonal antibody CSL362, which binds to CD123 with high affinity. We first validated the expression of CD123 by 100% (52/52) of patient samples and the correlation of NPM1 and FLT3-ITD mutations with the high frequency of CD123 in AML...
June 2, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28573700/long-term-follow-up-of-fontan-completion-in-adults-and-adolescents
#13
Tai Fuchigami, Mitsugi Nagashima, Takeshi Hiramatsu, Goki Matsumura, Minori Tateishi, Noriyasu Masuda, Kenji Yamazaki
BACKGROUND: The Fontan procedure is rarely performed in adults and adolescents in the present era. We review our results with the Fontan procedure in adolescents and young adults. METHODS: Between 1974 and 2010, 79 consecutive patients underwent the Fontan procedure at an age ≥ 15 years (mean age at Fontan operation, 20.3 years ± 4.5 years). Forty-five patients underwent atriopulmonary connection, 11 underwent the Bjork procedure, and 23 underwent total cavopulmonary connection...
July 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28570069/electrochemical-growth-of-copper-hydroxy-double-salt-films-and-their-conversion-to-nanostructured-p-type-cuo-photocathodes
#14
Allison C Cardiel, Kenneth J McDonald, Kyoung-Shin Choi
New electrochemical synthesis methods were developed to produce copper hydroxy double salt(Cu-HDS) films with four different intercalated anions (NO3(-), SO4(2-), Cl(-), and dodecyl sulfate (DS)) as pure crystalline films as deposited (Cu2NO3(OH)3, Cu4SO4(OH)6, Cu2Cl(OH)3, and Cu2DS(OH)3). These methods are based on p-benzoquinone reduction, which increases the local pH at the working electrode and triggers the precipitation of Cu(2+) and appropriate anions as Cu-HDS films on the working electrode. The resulting Cu-HDS films could be converted to crystalline Cu(OH)2 and CuO films by immersing them in basic solutions...
June 1, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28557471/the-double-edged-sword-of-leader-charisma-understanding-the-curvilinear-relationship-between-charismatic-personality-and-leader-effectiveness
#15
Jasmine Vergauwe, Bart Wille, Joeri Hofmans, Robert B Kaiser, Filip De Fruyt
This study advanced knowledge on charisma by (a) introducing a new personality-based model to conceptualize and assess charisma and by (b) investigating curvilinear relationships between charismatic personality and leader effectiveness. Moreover, we delved deeper into this curvilinear association by (c) examining moderation by the leader's level of adjustment and by (d) testing a process model through which the effects of charismatic personality on effectiveness are explained with a consideration of specific leader behaviors...
May 29, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28555362/the-incidence-of-drug-and-herbal-and-dietary-supplement-induced-liver-injury-preliminary-findings-from-gastroenterologist-based-surveillance-in-the-population-of-the-state-of-delaware
#16
Maricruz Vega, Manisha Verma, David Beswick, Stephanie Bey, Jared Hossack, Nathan Merriman, Ashish Shah, Victor Navarro
BACKGROUND AND AIM: The population-based incidence rate of drug-induced liver injury (DILI) in the USA is not known. The Drug-Induced Liver Injury Network (DILIN) accrues cases of hepatotoxicity due to medications and herbal and dietary supplements (HDS) from limited geographical areas. The current analysis was an ancillary study of DILIN aimed at determining the annual incidence of DILI in the USA on a population basis, through surveillance in the state of Delaware. METHODS: At the outset of the study, there were 41 gastroenterologists in the state of Delaware and all agreed to participate in surveillance for DILI, which comprised active reporting of suspected cases to the DILIN...
May 29, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28554973/d2o-and-hds-in-the-coma-of-67p-churyumov-gerasimenko
#17
K Altwegg, H Balsiger, J J Berthelier, A Bieler, U Calmonte, J De Keyser, B Fiethe, S A Fuselier, S Gasc, T I Gombosi, T Owen, L Le Roy, M Rubin, T Sémon, C-Y Tzou
The European Rosetta mission has been following comet 67P/Churyumov-Gerasimenko for 2 years, studying the nucleus and coma in great detail. For most of these 2 years the Rosetta Orbiter Sensor for Ion and Neutral Analysis (ROSINA) has analysed the volatile part of the coma. With its high mass resolution and sensitivity it was able to not only detect deuterated water HDO, but also doubly deuterated water, D2O and deuterated hydrogen sulfide HDS. The ratios for [HDO]/[H2O], [D2O]/[HDO] and [HDS]/[H2S] derived from our measurements are (1...
July 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28530769/beneficial-effects-of-garlic-allium-sativum-oil-in-experimental-corrosive-esophageal-burns-effects-of-garlic-oil-in-esophageal-burns
#18
Ceren Şen Tanrıkulu, Yusuf Tanrikulu, Fahriye Kılınç, Burak Bahadır, Murat Can, Füruzan Köktürk
BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28512048/combined-hyperactive-dysfunction-syndrome-of-the-cranial-nerves-a-retrospective-systematic-study-of-clinical-characteristics-in-44-patients
#19
Jingwei Cao, Jie Jiao, Zhenhui Du, Wenzhe Xu, Bin Sun, Feng Li, Yuguang Liu
BACKGROUND: Combined hyperactive dysfunction syndrome (HDS) is defined as the combination symptoms arising from overactivity in cranial nerves, specifically, trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia (GPN), without an obvious explanatory structural lesion. This study retrospectively analyzes the clinical characteristics of combined HDS treated with microvascular decompression (MVD) in a single institution. METHODS: A total of 1450 patients with HDS were treated with MVD in our department during a 10-year period, among which 44 cases of combined HDS were identified...
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28508833/radiation-induced-non-targeted-effect-in-vivo-evaluation-of-cyclooygenase-2-and-endothelin-1-gene-expression-in-rat-heart-tissues
#20
Reza Fardid, Masoud Najafi, Ashkan Salajegheh, Elahe Kazemi, Abolhasan Rezaeyan
AIM: In this study, we investigated expression levels of cyclooxygenase-2 (COX-2) and endothelin-1 (ET-1) genes after pelvis and heart irradiation in a rat model. These factors are involved in heart diseases (HDs). MATERIALS AND METHODS: We used seven groups, including two groups of pelvic irradiation, two groups of whole body irradiation, two groups of heart irradiation, and one control nonirradiated group. Pelvis irradiations were conducted at a 2 cm × 2 cm in the pelvis area...
January 2017: Journal of Cancer Research and Therapeutics
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