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https://www.readbyqxmd.com/read/28816580/cardioprotective-effects-of-a-phlorotannin-extract-against-doxorubicin-induced-cardiotoxicity-in-a-rat-model
#1
Hyo-Suk Ahn, Dong-Hyeon Lee, Tae-Jung Kim, Hyeon-Cheol Shin, Hui-Kyung Jeon
Long-term therapy with doxorubicin (DOX) is associated with high incidence of cumulative and irreversible dilated cardiomyopathy. The goal of this study was to evaluate the cardioprotective effects and safety of a phlorotannin extract from a brown algae Ecklonia cava (Seapolynol™, SPN) against DOX-induced cardiotoxicity in a rat model. A total of 42 rats were divided into six groups: control, low-dose SPN (LDS), high-dose SPN (HDS), DOX, DOX with low-dose SPN (DOX+LDS), and DOX with high-dose SPN (DOX+HDS)...
August 17, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28809800/effect-of-2-6-bis-1-hydroxy-1-1-diphenyl-methyl-pyridine-as-organic-additive-in-sulfide-nimop-%C3%AE-al%C3%A2-o%C3%A2-catalyst-for-hydrodesulfurization-of-straight-run-gas-oil
#2
Carlos Eduardo Santolalla-Vargas, Victor Santes, Erick Meneses-Domínguez, Vicente Escamilla, Agileo Hernández-Gordillo, Elizabeth Gómez, Felipe Sánchez-Minero, José Escobar, Leonardo Díaz, Oscar Goiz
The effect of 2,6-bis-(1-hydroxy-1,1-diphenyl-methyl) pyridine (BDPHP) in the preparation of NiMoP/γ-Al₂O₃ catalysts have been investigated in the hydrodesulfurization (HDS) of straight-run gas oil. The γ-Al₂O₃ support was modified by surface impregnation of a solution of BDPHP to afford BDPHP/Ni molar ratios (0.5 and 1.0) in the final composition. The highest activity for NiMoP materials was found when the molar ratio of BDPHP/Ni was of 0.5. X-ray diffraction (XRD) results revealed that NiMoP (0...
August 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28791517/psychometric-evaluation-of-the-interrai-child-and-youth-mental-health-disruptive-aggression-behaviour-scale-dabs-and-hyperactive-distraction-scale-hds
#3
Chloe Lau, Shannon L Stewart, Donald H Saklofske, Paul F Tremblay, John Hirdes
The present study aims to validate the interRAI Child and Youth Mental Health (interRAI ChYMH), Disruptive/Aggression Behaviour Scale (DABS) and Hyperactive/Distraction Scale (HDS). Data were collected from children/youth aged 4-18 (N = 3464) across 39 mental health agencies in Ontario, Canada. Unrestricted factor analysis using polychoric correlation matrices and Samejima's graded item response theory (IRT) parameterizations were conducted for both measures. Scores on the HDS and DABS were also compared amongst children/youth diagnosed with attention-deficit hyperactivity disorder (ADHD) and disruptive behaviour disorder (DBD) respectively using DSM-IV criteria...
August 8, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28783374/hiv-and-cognitive-impairment-in-clinical-practice-the-evaluation-of-a-stepwise-screening-protocol-in-relation-to-clinical-outcomes-and-management
#4
Charlotte S Hakkers, Jordan M Kraaijenhof, Esther B van Oers-Hazelzet, Anne J M A Visser-Meily, Andy I M Hoepelman, Joop E Arends, Roos E Barth
Neurocognitive impairment (NCI) is an increasingly important comorbidity in an ageing HIV+ population. Despite the lack of available treatment modalities, screening for NCI is recommended. In the UMC Utrecht, yearly NCI screening is done using the Montreal Cognitive Assessment (MoCA) tool and the HIV Dementia Scale (HDS). The aim of this study was to evaluate this screening protocol in relation to clinical outcomes and management. A retrospective cohort study was performed in suppressed adult HIV+ patients...
August 7, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28771932/acute-liver-failure-induced-by-idiosyncratic-reaction-to-drugs-challenges-in-diagnosis-and-therapy
#5
Shannan R Tujios, William M Lee
Acute liver failure (ALF) requires urgent attention to identify etiology and determine prognosis, in order to assess likelihood of survival or need for transplantation. Identifying idiosyncratic drug-induced liver injury (iDILI) may be particularly difficult, but the illness generally follows a subacute course, allowing time to assess outcome and find a liver graft if needed. Not all drugs that cause iDILI lead to ALF; the most common are antibiotics including anti-tuberculous medications, non-steroidal anti-inflammatory agents and herbal and dietary supplements (HDS)...
August 3, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28763782/molecular-imprinting-coupled-with-electrochemical-analysis-for-plasma-samples-classification-in-acute-myocardial-infarction-diagnostic
#6
Victoria V Shumyantseva, Tatiana V Bulko, Larisa V Sigolaeva, Alexey V Kuzikov, Pavel V Pogodin, Alexander I Archakov
Electroanalysis of myoglobin (Mb) in 10 plasma samples of healthy donors (HDs) and 14 plasma samples of patients with acute myocardial infarction (AMI) was carried out with screen-printed electrodes modified first with multi-walled carbon nanotubes (MWCNT) and then with a molecularly imprinted polymer film (MIP), viz., myoglobin-imprinted electropolymerized poly(o-phenylenediamine). The differential pulse voltammetry (DPV) parameters, such as a maximum amplitude of reduction peak current (A, nA), a reduction peak area (S, nA × V), and a peak potential (P, V), were measured for the MWCNT/MIP-sensors after their incubation with non-diluted plasma...
July 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28758350/nanostructured-three-dimensional-3d-assembly-of-2d-mos2-and-graphene-directly-built-from-acidic-graphite-oxide
#7
Sunil P Lonkar, Vishnu V Pillai, Saeed Alhassan
A 3D highly interconnected macroporous network of reduced GO having finely dispersed few-layered 2D MoS2 nanosheets was constructed through direct use of acidic graphite oxide (GO) for the first time. This facile and technological scalable process can afford an efficient electrocatalysts, anode materials, HDS catalysts at lower cost and can circumvent the poor thermal stability and recyclability of the material. The strategy provided here can be the basis to design and develop practical processes to address the ultimate goal of large-scale manufacturing of hybrids composed of 2D materials for various energy and catalysis applications...
July 30, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28758099/platelet-expression-of-pkcepsilon-oncoprotein-in-myelofibrosis-is-associated-with-disease-severity-and-thrombotic-risk
#8
Elena Masselli, Cecilia Carubbi, Giulia Pozzi, Silvia Martini, Franco Aversa, Daniela Galli, Giuliana Gobbi, Prisco Mirandola, Marco Vitale
BACKGROUND: Myelofibrosis (MF) is the most aggressive Philadelphia-negative chronic myeloproliferative neoplasm (MPN) with high morbidity and mortality due to thrombo-hemorrhagic complications and leukemic transformation. MF is characterized by profound alterations of megakaryocytopoiesis, with consequent abnormalities in platelet number and function. We recently showed that the overexpression of the oncoprotein PKCepsilon plays a key role in the aberrant differentiation of MF megakaryocyte clone and that its levels correlate with disease burden...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28756703/hydrodemetallation-and-hydrodesulfurization-spent-catalysts-elemental-analysis-comparison-of-wavelength-dispersive-x-ray-fluorescence-and-atomic-emission-spectrometries
#9
Laetitia Garoux, Sébastien Gourhand, Marc Hébrant, Michel Schneider, Sébastien Diliberto, Eric Meux
Petroleum industries continuously consume catalysts on very large scales. The recycling of spent catalysts is thus of major economic and environmental importance and its first step consists of the characterization of the valuable metal content. Wavelength dispersive X-ray fluorescence (WDXRF) analysis is compared with inductively coupled plasma atomic emission spectrometry (ICP-AES) for the analysis of five samples of spent hydrodesulphurization (HDS) and hydrodemetallization (HDM) catalysts. The elements are considered for their economic interest (Co, Ni, Mo, and V) or for the problems that can arise when they are present in the sample in significant quantities (Al, As, P, Fe)...
August 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28724795/alx-receptor-ligands-define-a-biochemical-endotype-for-severe-asthma
#10
Isabell Ricklefs, Ioanna Barkas, Melody G Duvall, Manuela Cernadas, Nicole L Grossman, Elliot Israel, Eugene R Bleecker, Mario Castro, Serpil C Erzurum, John V Fahy, Benjamin M Gaston, Loren C Denlinger, David T Mauger, Sally E Wenzel, Suzy A Comhair, Andrea M Coverstone, Merritt L Fajt, Annette T Hastie, Mats W Johansson, Michael C Peters, Brenda R Phillips, Bruce D Levy
BACKGROUND: In health, inflammation resolution is an active process governed by specialized proresolving mediators and receptors. ALX/FPR2 receptors (ALX) are targeted by both proresolving and proinflammatory ligands for opposing signaling events, suggesting pivotal roles for ALX in the fate of inflammatory responses. Here, we determined if ALX expression and ligands were linked to severe asthma (SA). METHODS: ALX expression and levels of proresolving ligands (lipoxin A4 [LXA4], 15-epi-LXA4, and annexin A1 [ANXA1]), and a proinflammatory ligand (serum amyloid A [SAA]) were measured in bronchoscopy samples collected in Severe Asthma Research Program-3 (SA [n = 69], non-SA [NSA, n = 51] or healthy donors [HDs, n = 47])...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28720527/usefulness-of-percutaneous-endoscopic-lumbar-foraminoplasty-for-lumbar-disc-herniation
#11
Kyung-Chul Choi, Hyeong-Ki Shim, Chan Jin Park, Dong Chan Lee, Choon-Keun Park
OBJECTIVE: Endoscopic foraminoplasty facilitates the engagement of the working cannula via the intervertebral foramen, allowing cannula access near the herniated disc (HD) for the successful application of percutaneous endoscopic lumbar discectomy (PELD). The purpose of this study was to evaluate the efficacy of foraminoplasty for HD and propose applicable situations for foraminoplasty in PELD. METHODS: A retrospective review of consecutive patients who underwent PELD was performed...
July 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28708496/comparative-evaluation-of-haematological-parameters-and-erythrocyte-membrane-stability-in-pregnant-and-lactating-goats-in-different-seasons-of-tropical-savannah
#12
B Habibu, H J Makun, L S Yaqub, H U Buhari, T Aluwong, M U Kawu
Haematological parameters and erythrocyte osmotic fragility (EOF) are commonly used as indicators of health status and erythrocyte membrane integrity. Variations in haematological parameters and EOF in late gestation and early lactation during the cold-dry (CDS), hot-dry (HDS) and rainy (RAS) seasons were studied in sixty (n = 60) Red Sokoto goats (20 goats for each season). The ambient temperatures and temperature-humidity index recorded were higher in the afternoon hours of the HDS and RAS, but lower in the morning hours of the CDS as compared with the thermoneutral zone of goats...
September 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28694622/pulmonary-involvement-in-patients-with-guillain-barr%C3%A3-syndrome-in-subacute-phase
#13
Meeka Khanna, Nidhi Rawat, Anupam Gupta, Madhu Nagappa, Arun B Taly, M R Rukmani, T N Sathyaprabha, Partha Haldar
OBJECTIVES: To evaluate the pulmonary function in Guillain-Barre syndrome (GBS) patients in subacute phase and find clinical correlates of pulmonary dysfunction. METHODS: This was a single-center, prospective, cross-sectional, hospital-based study in GBS patients performed in Department of Neurological Rehabilitation at a tertiary care institute. Clinical examination for pulmonary function was done by measuring chest expansion. The pulmonary function tests were carried out by Spirometry kit Microquark Cosmed, Italy...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28679857/challenges-in-the-medical-management-of-symptomatic-intracranial-stenosis-in-an-urban-setting
#14
Rajbeer S Sangha, Andrew M Naidech, Carlos Corado, Sameer A Ansari, Shyam Prabhakaran
BACKGROUND AND PURPOSE: Since the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), aggressive medical management (AMM), which includes dual antiplatelet therapy (DAPT) and high-dose statin (HDS) therapy, is recommended for patients with symptomatic intracranial atherosclerotic disease. However, limited data on the real-world application of this regimen exist. We hypothesized that recurrent stroke risk among patients treated with AMM is similar to the medical arm of the SAMMPRIS cohort...
August 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28677257/33s-label-tracing-for-hydrodesulfurization-process-insights-into-the-reaction-mechanism-catalyst-characterization-and-improvement
#15
Vitaly L Sushkevich, Andrey G Popov, Irina I Ivanova
The novel approach based on 33S label tracing is proposed for the elucidation of hydrodesulfurization (HDS) mechanisms and characterization of molybdenum sulfide catalysts. The technique involves sulfidation of the catalyst with dihydrogen sulfide labeled with the 33S isotope, followed by monitoring the fate of 33S label in the course of hydrodesulfurization reaction by on-line mass spectrometry and characterization of the catalyst after the reaction by TPO-MS. The results point to different pathways of thiophene transformation over Co or Ni promoted and unpromoted molybdenum sulfide catalysts, provide information on the role of promoter and give a key for the design of new efficient HDS catalysts...
July 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28650500/insight-into-thiophene-hydrodesulfurization-on-clean-and-s-modified-mop-010-a-periodic-density-functional-theory-study
#16
Guixia Li, Lianming Zhao, Houyu Zhu, Xiuping Liu, Huifang Ma, Yanchen Yu, Wenyue Guo
The hydrodesulfurization (HDS) of thiophene on clean and S-modified MoP(010) is investigated to understand the HDS mechanism as well as the surface sulfur (S) atom effect using periodic density functional theory (DFT). The results show that thiophene prefers strongly flat adsorption on both the clean and S-modified surfaces, in either the molecular state or the dissociative state breaking simultaneously one C-S bond, and the adsorption of thiophene can be slightly weakened by the surface S atom. Thermodynamic and kinetic analysis indicates that the HDS of thiophene in both the molecular and dissociative adsorption states prefers to take place along the direct desulfurization (DDS) pathway rather than hydrogenation on both the clean and S-modified MoP(010) surfaces...
June 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28626259/lao-language-version-of-the-revised-hasegawa-s-dementia-scale
#17
Sengchanh Kounnavong, Khouanchay Soundavong, Syda Xayavong, Nialoun Vongpraserth, Phongsavang Bounsavath, Souphatsone Houatthongkham, Bounfeng Phoummalaysith, Yu Mon Saw, Eiko Yamamoto, Kenji Toba, Nobuyuki Hamajima
With the aging of society, the number of elderly with reduced cognitive function has been increasing worldwide. As a test to measure the cognitive function, the Revised Hasegawa's Dementia Scale (HDS-R) has been used in Japan, Korea, and China. Since there was no HDS-R version for Laotians, the questionnaire and manual were developed through the cooperation of Lao and Japanese researchers. Back-translation was conducted to confirm the accuracy of the translation. The score on the 9-item HDS-R ranges 0 to 30 points, and reduced cognitive function is usually defined as a score of 20 points or lower...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28611660/neurodegeneration-and-the-circadian-clock
#18
REVIEW
Suzanne Hood, Shimon Amir
Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical activities (e.g., antioxidant production). Circadian disturbances are among the earliest symptoms of these diseases, and the molecular mechanisms of the circadian system are suspected to play a pivotal, and possibly causal, role in their natural histories...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28592739/a-case-of-idiopathic-normal-pressure-hydrocephalus-in-an-elder-diabetic-patient
#19
Kyoko Kawakami, Hiroshi Yoshino, Hiroyuki Igarashi, Yoshiyuki Chiba, Gen Yoshino, Takahisa Hirose
The clinical entity idiopathic normal pressure hydrocephalus (iNPH) is characterized by dementia, urinary incontinence, gait ataxia. An 80-year old man with a past history of Type 2 diabetes mellitus admitted to our hospital. Combination of twice Aspart and Aspart premixed30/70 insulin were used. Although, he was unable to inject insulin by himself recently. On physical examination, he walked in a mildly wide based manner. According to his family, urinary incontinence was existed. Laboratory data were as follows: Postrandial blood glucose 243 mg/dl and glycated hemoglobin 8...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28579128/the-role-of-hunger-state-and-dieting-history-in-neural-response-to-food-cues-an-event-related-potential-study
#20
Emily H Feig, Samantha R Winter, John Kounios, Brian Erickson, Staci A Berkowitz, Michael R Lowe
A history of dieting to lose weight has been shown to be a robust predictor of future weight gain. A potential factor in propensity towards weight gain is the nature of people's reactions to the abundance of highly palatable food cues in the environment. Event Related Potentials (ERPs) have revealed differences in how the brain processes food cues between obese and normal weight individuals, as well as between restrained and unrestrained eaters. However, comparisons by weight status are not informative regarding whether differences predate or follow weight gain in obese individuals and restrained eating has not consistently been found to predict future weight gain...
June 1, 2017: Physiology & Behavior
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