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https://www.readbyqxmd.com/read/29101675/red-blood-cell-distribution-width-a-potential-laboratory-parameter-for-monitoring-inflammation-in-rheumatoid-arthritis
#1
Yujue He, Can Liu, Zhiyong Zeng, Weilin Ye, Jinpiao Lin, Qishui Ou
Correlation analysis of red blood cell distribution width (RDW) and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-10 in rheumatoid arthritis (RA) to investigate whether RDW can serve as a potential parameter for indicating inflammation in RA patients. A total of 670 RA patients from October 2014 to April 2016 were enrolled in our study. The white blood cell (WBC), red blood cell (RBC), platelet (PLT), hemoglobin (HGB), RDW, CRP, and ESR in peripheral blood of patients with RA were retrospectively analyzed...
November 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29096376/substrate-mediated-gene-transduction-of-lama3-for-promoting-biological-sealing-between-titanium-surface-and-gingival-epithelium
#2
Jing Zhang, Huiming Wang, Ying Wang, Wenjing Dong, Zhiwei Jiang, Guoli Yang
A good biological sealing between soft tissues and an implant could minimize the risk of peri-implantitis. Like the junctional epithelium, the peri-implant epithelium attaches to the surface of the implant via hemidesmosomes (HDs) and internal basal lamina (extracellular matrix containing laminin332, IBL). A multilayer coating modified with the laminin332 gene (LAMA3) on the titanium implant surface is developed here via layer-by-layer assembly and antibody-antigen specific binding for substrate-mediated gene transduction...
October 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29081128/-clinical-effect-of-high-pressure-oxygen-and-butylphthalide-in-the-recovery-of-cerebral-metabolism-after-carbon-monoxide-poisoning
#3
Q Han, X T Guo, H H Zhang, R Tian, X Gao, Z Q Zhang
Objective: To study the clinical effect of high pressure oxygen and Butylphthalide in the recovery of cerebral metabolism after carbon monoxide poisoning. Methods: 84 patients treated from May 2014 to May 2016 in our hospital were selected. The subjects were randomly and equally divided into two groups. The control group adopted the conventional therapy and high pressure oxygen; on the basis, the observation group also took Butylphthalide. The clinical effect, duration of coma, recovery of consciousness, incidence rate of delayed encephalopathy was observed...
August 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29067264/outpatient-management-of-steroid-induced-hyperglycaemia-and-steroid-induced-diabetes-in-people-with-lymphoproliferative-disorders-treated-with-intermittent-high-dose-steroids
#4
Jennifer Vidler, Charlotte Rogers, Deborah Yallop, Stephen Devereux, Ellinor Wellving, Orla Stewart, Alison Cox, Katharine F Hunt, Shireen Kassam
High dose steroids (HDS) are used in the treatment of haematological malignancies. The reported risk of steroid-induced diabetes (SID) is high. However, screening is not consistently performed. We implemented a protocol for detection and management of SID and steroid-induced hyperglycamia (SIH) in haematology outpatients receiving HDS. Eighty-three people were diagnosed with a lymphoproliferative disorder, of whom 6 had known Type 2 diabetes. Fifty-three people without known diabetes were screened by HbA1c and random venous plasma glucose...
September 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29063076/restless-legs-syndrome-secondary-to-pontine-infarction-clinical-analysis-of-five-cases
#5
Hou-Zhen Tuo, Ze-Long Tian, Yi-Nong Cui, Xiao-Yang Ma, Chun-Ling Xu, Hong-Yan Bi, Li-Yan Zhang, Yong-Bo Zhang, Wei-Dong Le, William Ondo
OBJECTIVE: Pontine infarction is a common type of stroke in the cerebral deep structures, resulting from occlusion of small penetrating arteries, may manifest as hemi-paralysis, hemi-sensory deficit, ataxia, vertigo, and bulbar dysfunction, but patients presenting with restless legs syndrome (RLS) are extremely rare. Herein, we reported five cases with RLS as a major manifestation of pontine infarction. METHODS: Five cases of pontine infarction related RLS were collected from July 2013 to February 2016...
September 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/29060102/electromyogram-based-method-to-secure-wireless-body-sensor-networks-for-rehabilitation-systems
#6
Guanghe Zhang, Oluwarotimi Williams Samuel, Fanghua Liu, Shixiong Chen, Hui Zhou, Haoshi Zhang, Guanglin Li
Wireless body sensor networks (WBSNs) provide a platform to track and monitor human health status as well as feedback to the user by capturing and processing certain physiological signals. Since WBSNs need to provide efficient health information privacy, their security has been identified as one of the major challenges, especially for rehabilitation systems. Conventionally, the random numbers (RNs) based on the inter-pulse intervals (IPIs) from electrocardiogram (ECG) recordings have been widely used to secure the data in WBSNs...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29042636/dysfunctional-early-processing-of-facial-expressions-in-hazardous-drinkers-evidence-from-an-erp-study
#7
Hui Zhang, Yi Jin, John S Y Chan, Feng-Chi Yang, Fang Cui
Chronic alcohol intoxication impairs multiple cognitive functions. According to the dual system model (DSM), the development of alcohol dependence (AD) involves the imbalance between the automatic-affective system and the reflective system. However, the cognitive functions of non-AD hazardous drinkers (HDs) remain unclear. The present study aimed to explore how the HDs process facial expressions differently from the healthy subjects. Sixteen HDs and seventeen control subjects (CSs) completed an emotional working memory (WM) task while the electroencephalogram (EEG) was recorded...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040788/familial-mediterranean-fever-mutations-are-hypermorphic-mutations-that-specifically-decrease-the-activation-threshold-of-the-pyrin-inflammasome
#8
Yvan Jamilloux, Lucie Lefeuvre, Flora Magnotti, Amandine Martin, Sarah Benezech, Omran Allatif, Mathilde Penel-Page, Véronique Hentgen, Pascal Sève, Mathieu Gerfaud-Valentin, Agnès Duquesne, Marine Desjonquères, Audrey Laurent, Vanessa Rémy-Piccolo, Rolando Cimaz, Luca Cantarini, Emilie Bourdonnay, Thierry Walzer, Bénédicte F Py, Alexandre Belot, Thomas Henry
Objectives: FMF is the most frequent autoinflammatory disease and is associated in most patients with bi-allelic MEFV mutations. MEFV encodes Pyrin, an inflammasome sensor activated following RhoGTPase inhibition. The functional consequences of MEFV mutations on the ability of Pyrin variants to act as inflammasome sensors are largely unknown. The aim of this study was to assess whether MEFV mutations affect the ability of Pyrin to detect RhoGTPase inhibition and other inflammasome stimuli...
October 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/29026061/from-specific-humidifier-disinfectants-disease-to-humidifier-disinfectants-syndrome
#9
Jong-Han Leem, Jong-Hyeon Lee
Humidifier disinfectant damage was terrible chemical damage caused by household goods that happened in only South Korea, but it is still very little known in humidifier disinfectant damage. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole and alveoli because it is specific finding, compared with other diseases. To figure out overall effects from HDs, many epidemiologic and toxicologic research is underway. Humidifier disinfectants showed to give rise to typical toxicologic effects on various target organs, such as skin, conjunctiva, naval mucosa, bronchial mucosa, alveoli and so on, which were sharing common toxicological responses...
October 7, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28994211/sleep-duration-is-associated-with-sperm-chromatin-integrity-among-young-men-in-chongqing-china
#10
Xiaogang Wang, Qing Chen, Peng Zou, Taixiu Liu, Min Mo, Huan Yang, Niya Zhou, Lei Sun, Hongqiang Chen, Xi Ling, Kaige Peng, Lin Ao, Huifang Yang, Jia Cao, Zhihong Cui
This study explores whether sleep duration is associated with sperm chromatin integrity. To do so, we conducted a three-phase panel study of 796 male volunteers from colleges in Chongqing (China) from 2013 to 2015. Sleep duration was measured using a modified Munich Chronotype Questionnaire. Sperm DNA integrity was examined via Sperm Chromatin Structure Assay and Comet assay. Setting 7-7.5 h day(-1) of sleep duration as a reference, either longer or shorter sleep duration was associated negatively with high DNA stainability (HDS) (P = 0...
October 9, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28991661/behavioral-and-affective-features-of-amyotrophic-lateral-sclerosis-patients
#11
Yasuyuki Ohta, Kota Sato, Mami Takemoto, Yoshiaki Takahashi, Ryuta Morihara, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Nozomi Hishikawa, Toru Yamashita, Koji Abe
Evaluating the cognitive and behavioral features in amyotrophic lateral sclerosis (ALS) patients is important for therapy and care. Fifty-seven ALS, 5 ALS with the behavioral variant of frontotemporal dementia (FTD) (ALS-FTD), 12 FTD patients, and 35 control subjects were evaluated by 10 different tests for cognitive and behavioral (mini-mental state examination (MMSE), Hasegawa dementia rating scale - revised (HDS-R), frontal assessment battery (FAB), Montreal cognitive assessment (MoCA), ALS-frontotemporal dementia-Questionnaire (ALS-FTD-Q), and anosognosia scale), affective (depression, apathy, and behavioral and psychological symptoms of dementia (BPSD)), and activities of daily living (ADL) assessments...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28987088/rate-of-hemifusion-diaphragm-dissipation-and-ability-to-form-three-junction-bound-hd-determined-by-lipid-composition
#12
Jasmine M Gardner, Cameron F Abrams
Though the hemifusion diaphragm (HD) is widely accepted as an intermediate in bilayer membrane fusion, lipid contributions toward HD stability and dynamics are still not fully understood. In this paper, we study large, binary, protein-free HD systems at varying compositions of negative intrinsic curvature (NIC) lipids using molecular dynamics (MD) simulations of a solvent-free coarse-grained lipid model. Under MD, initially created HDs are found to relax to three major end states depending on the composition and lipid intrinsic curvature...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28971029/comparison-of-pulmonary-artery-catheter-echocardiography-and-arterial-waveform-analysis-monitoring-in-predicting-the-hemodynamic-state-during-and-after-cardiac-surgery
#13
Paul Power, Allison Bone, Nicholas Simpson, Cheng-Hon Yap, Simon Gower, Michael Bailey
OBJECTIVE: The aim of this trial was to determine whether Flotrac Vigileo™ (FV™) provides a reliable representation of the hemodynamic state of a cardiac surgical patient population when compared to pulmonary artery catheter (PAC) and echocardiography in the peril-operative period. DESIGN: This was a prospective observational trial comparing perioperative hemodynamic states using transesophageal echocardiography (TEE), transthoracic echocardiography (TTE), FV™ and PAC during and post cardiothoracic surgery...
July 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28966958/salient-features-and-outline-of-the-joint-japanese-guidelines-for-safe-handling-of-cancer-chemotherapy-drugs
#14
Kiyoko Kanda, Kazue Hirai, Keiko Iino, Hisanaga Nomura, Hisateru Yasui, Taro Kano, Chisato Ichikawa, Sumiko Hiura, Tomoko Morita, Ayako Mitsuma, Hiroko Komatsu
The purpose of this paper is to introduce the outline and describe the salient features of the "Joint Guidelines for Safe Handling of Cancer Chemotherapy Drugs" (hereinafter, "Guideline"), which were published in July 2015. The purpose of this Guideline is to provide guidance to protect against occupational exposure to hazardous drugs (HDs) to all medical personnel involved in cancer chemotherapy, including physicians, pharmacists, and nurses and home health-care providers. The Guideline was developed according to the Medical Information Network Distribution Service guidance for developing clinical practice guidelines, with reference to five authoritative guidelines used worldwide...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28953776/selective-serotonergic-ssri-versus-noradrenergic-snri-reuptake-inhibitors-with-and-without-acetylsalicylic-acid-in-major-depressive-disorder
#15
Nicolas Zdanowicz, Christine Reynaert, Denis Jacques, Brice Lepiece, Thomas Dubois
BACKGROUND: Antidepressant medication efficacy remains a major research challenge. Here, we explored four questions: whether noradrenergic antidepressants are more effective than serotonergic antidepressants; whether the addition of 100 mg acetylsalicylic acid (ASA) changes antidepressant efficacy; whether the long-term efficacy differs depending on the antidepressant and the addition of ASA; and whether serum levels of brain-derived neurotrophic factor (BDNF) are clinically informative...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28926172/hydrogen-transfer-mediated-%C3%AE-functionalization-of-1-8-naphthyridines-by-a-strategy-overcoming-the-over-hydrogenation-barrier
#16
Xiu-Wen Chen, He Zhao, Chun-Lian Chen, Huan-Feng Jiang, Min Zhang
A general catalytic hydrogen transfer-mediated α-functionalization of 1,8-naphthyridines is reported for the first time that benefits from a hydrogen transfer-mediated activation mode for non-activated pyridyl cores. The pyridyl α-site selectively couples with the C8-site of various tetrahydroquinolines (THQs) to afford novel α-functionalized tetrahydro 1,8-naphthyridines, a class of synthetically useful building blocks and potential candidates for the discovery of therapeutic and bio-active products. The utilization of THQs as inactive hydrogen donors (HDs) appears to be a key strategy to overcome the over-hydrogenation barrier and address the chemoselectivity issue...
September 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28925897/role-of-apoptosis-in-the-pathogenesis-of-common-variable-immunodeficiency-cvid
#17
Mazdak Ganjalikhani-Hakemi, Reza Yazdani, Mohammad Esmaeili, Hassan Abolhassani, Wiliam Rae, Gholamreza Azizi, Majid Zaki Dizaji, Mohammadreza Shaghaghi, Faezeh Abbasi-Rad, Abbas Rezaei, Sanaz Afshar-Qasemloo, Saeed Mohammadi, Nima Rezaei, Asghar Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is a heterogeneous immune deficiency characterized by hypogammaglobulinemia. Since B cell maturation and differentiation is defective in this disorder, we evaluated apoptosis in B cells of patients with CVID compared with healthy donors (HD). METHODS: Determination of peripheral blood B-cell subsets in CVID and HDs, was performed using flow cytometry. We compared total apoptosis, early apoptosis and late apoptosis/necrosis in unstimulated and stimulated B-cells of patients with CVID and HDs...
September 19, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28895915/-autoimmune-like-drug-and-herb-induced-liver-injury-new-insights-into-molecular-pathogenesis
#18
REVIEW
Marcial Sebode, Lisa Schulz, Ansgar W Lohse
Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of autoantibodies and infiltration of the liver by immune competent cells. To describe these cases of DILI/HDS, the poorly-defined term "autoimmune(-like)" DILI/HDS came up. It is uncertain if these cases represent a subgroup of DILI/HDS with distinct pathomechanistic and prognostic features different from "classical" DILI/HDS...
September 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28893450/emergency-medicine-evaluation-and-management-of-the-end-stage-renal-disease-patient
#19
REVIEW
Brit Long, Alex Koyfman, Courtney M Lee
BACKGROUND: End stage renal disease (ESRD) is increasing in the U.S., and these patients demonstrate greater all-cause mortality, cardiovascular events, and hospitalization rates when compared to those with normal renal function. These patients may experience significant complications associated with loss of renal function and dialysis. OBJECTIVE: This review evaluates complications of ESRD including cardiopulmonary, neurologic, infectious disease, vascular, and access site complications, as well as medication use in this population...
September 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28890042/guillain-barre-syndrome-in-the-elderly-experience-from-a-tertiary-care-hospital-in-india
#20
M Nagappa, W Rahul, S Sinha, P S Bindu, P S Mathuranath, S Rao, S Periyavan, G S Umamaheshwara Rao, A B Taly
Age influences incidence and prognosis of Guillain Barre Syndrome (GBS), common cause of ascending areflexic quadriparesis. Dedicated studies on elderly GBS are infrequent. This study aimed to describe clinical features and outcome at hospital-discharge in patients aged≥60years with GBS. Medical records of 70 elderly GBS over 15years were analysed. Mean symptom-duration was 5.78±4.5days and onset-to-peak 5.14±4.4days. Antecedent events preceded GBS by 8.07±9.9days and included: fever (n=19), respiratory infection (n=6), and gastroenteritis (n=5)...
December 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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