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https://www.readbyqxmd.com/read/28210619/a-useful-tool-as-a-medical-checkup-in-a-general-population-bioelectrical-impedance-analysis
#1
Mika Enomoto, Hisashi Adachi, Ako Fukami, Eita Kumagai, Sachiko Nakamura, Yume Nohara, Shoko Kono, Erika Nakao, Nagisa Morikawa, Tomoko Tsuru, Akiko Sakaue, Yoshihiro Fukumoto
Accumulation of visceral fat leads to metabolic syndrome and increases risks of cerebro-cardiovascular diseases, which should be recognized and improved at the early stage in general population. Accurate measurement of visceral fat area (VFA) is commonly performed by the abdominal cross-sectional image measured by computed tomography scan, which is, however, limited due to the radiation exposure. The bioelectrical impedance analysis (OMRON, HDS-2000 DUALSCAN(R)) has been recently developed to measure VFA, which is more easily accessible modality...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28199143/randomized-trial-comparing-r-chop-versus-high-dose-sequential-chemotherapy-in-high-risk-patients-with-diffuse-large-b-cell-lymphomas
#2
Sergio Cortelazzo, Corrado Tarella, Alessandro Massimo Gianni, Marco Ladetto, Anna Maria Barbui, Andrea Rossi, Giuseppe Gritti, Paolo Corradini, Massimo Di Nicola, Caterina Patti, Antonino Mulé, Manuela Zanni, Valerio Zoli, Atto Billio, Andrea Piccin, Giovanni Negri, Claudia Castellino, Francesco Di Raimondo, Andrés J M Ferreri, Fabio Benedetti, Giorgio La Nasa, Guido Gini, Livio Trentin, Maurizio Frezzato, Leonardo Flenghi, Simona Falorio, Marco Chilosi, Riccardo Bruna, Valentina Tabanelli, Stefano Pileri, Arianna Masciulli, Federica Delaini, Cristina Boschini, Alessandro Rambaldi
Purpose The benefit of high-dose chemotherapy with autologous stem-cell transplantation (ASCT) as first-line treatment in patients with diffuse large B-cell lymphomas is still a matter of debate. To address this point, we designed a randomized phase III trial to compare rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)-14 (eight cycles) with rituximab plus high-dose sequential chemotherapy (R-HDS) with ASCT. Patients and Methods From June 2005 to June 2011, 246 high-risk patients with a high-intermediate (56%) or high (44%) International Prognostic Index score were randomly assigned to the R-CHOP or R-HDS arm, and 235 were analyzed by intent to treat...
November 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28197588/an-unexpected-pathway-for-hydrodesulfurization-of-gazole-over-a-comos-active-phase-supported-on-a-mesoporous-tio2-catalyst
#3
I Naboulsi, C Felipe Linares Aponte, B Lebeau, S Brunet, L Michelin, M Bonne, J L Blin
Using dual mesoporous titania as a support, due to the presence of intrinsic Brönsted acid sites, the main approach to 4,6-dimethylbenzothiophene (46DMDBT) hydrodesulfurization (HDS) becomes the direct desulfurization (DDS) route through isomerization and dismutation reactions, instead of the hydrogenation (HYD) pathway usually observed with a conventional promoted (by Ni or Co) MoS2/Al2O3 catalyst.
February 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28188954/comparative-glandular-trichome-transcriptome-based-gene-characterization-reveals-reasons-for-differential-menthol-biosynthesis-in-mentha-species
#4
Md Qussen Akhtar, Nida Qamar, Pallavi Yadav, Pallavi Kulkarni, Ajay Kumar, Ajit Kumar Shasany
The genes involved in menthol biosynthesis are reported earlier in Mentha × piperita. But the information on these genes is not available in Mentha arvensis. To bridge the gap in knowledge on differential biosynthesis of monoterpenes leading to compositional variation in the essential oil of these species, a comparative transcriptome analysis of the glandular trichome was carried out. In addition to the MVA and MEP pathway genes, about 210 and 196 different terpene synthases (TPS) transcripts were identified from annotation in M...
February 11, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28159767/ticagrelor-reversal-in-vitro-assessment-of-four-haemostatic-agents
#5
Leyla Calmette, Anne-Céline Martin, Bernard Le Bonniec, Diane Zlotnik, Isabelle Gouin-Thibault, Christilla Bachelot-Loza, Pascale Gaussem, Anne Godier
AIM: Management of ticagrelor-induced bleeding is challenging as platelet transfusion is ineffective. An effective strategy is needed. This study aimed to investigate in vitro the efficacy of four haemostatic drugs (HDs), namely recombinant activated factor VII (rFVIIa), fibrinogen concentrate (Fib), tranexamic acid (TXA) and factor XIII concentrate (FXIII) to improve the haemostatic capacity in the presence of ticagrelor. METHODS: Blood was spiked with ticagrelor then supplemented by either HD or control...
February 3, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28152831/is-there-a-relationship-between-self-reported-healthy-days-and-comorbidity-medication-adherence-among-oncology-patients
#6
Dana Drzayich Jankus, Sari Hopson, Raya Khoury, Aparna Parikh, Alisha Stein, Todd Michael, Stephen Stemkowski, Mikele Bunce
: 189 Background: Previous studies established the link between comorbidities and Health Related Quality of Life (HRQoL) for cancer patients. Adherence to comorbid medications has been found to be predictive of HRQoL in other disease states, but this has not been established for patients with cancer. This study sought to investigate the association between healthy days (HDs) and comorbidity medication adherence (CMA) for cancer patients. METHODS: A survey was mailed to 5,098 patients with metastatic breast, lung or colorectal cancer who received treatment in 2014 and had at least one comorbid condition...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151723/direct-measurement-of-the-effective-infrared-dielectric-response-of-highly-doped-semiconductor-metamaterial
#7
Abeer Al Mohtar, Michel Kazan, Thierry Taliercio, Laurent Cerutti, Sylvain Blaize, Aurelien Bruyant
We have investigated the effective dielectric response of a subwavelength grating made of highly doped semiconductors (HDS) excited in reflection, using numerical simulations and spectroscopic measurement. The studied system can exhibit strong localized surface resonances and has therefore a great potential for surface enhanced infrared absorption (SEIRA) spectroscopy application. It consists of a highly doped InAsSb grating deposited on lattice matched GaSb. The numerical analysis demonstrated that the resonance frequencies can be inferred from the dielectric function of an equivalent homogeneous slab by accounting for the complex reflectivity of the composite layer...
February 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28107333/u-s-pharmacopeial-chapter-800-be-ready-to-comply-by-july-2018-%C3%A2
#8
Martha Polovich
The U.S. Pharmacopeial Convention's "Chapter <800> Hazardous Drugs-Handling in Healthcare Settings" is a new part of the National Formulary that describes standards-expectations for practice-for all aspects of handling and administering hazardous drugs (HDs). Some of the standards will require changes in policies, procedures, and practices for nurses. This article provides an overview of the new standards and the impact they will have on nurses who prepare and administer chemotherapy and other HDs.
...
February 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28104459/validation-of-the-intervertebral-disc-histological-degeneration-score-in-cervical-intervertebral-discs-and-their-end-plates
#9
Krzysztof A Tomaszewski, Brandon Michael Henry, Tomasz Gładysz, Roman Głowacki, Jerzy A Walocha, Romana Tomaszewska
BACKGROUND CONTEXT: Vertebral joints consist of intervertebral discs (IVDs) and cartilaginous end plates (EP) that lie superiorly and inferiorly to the IVDs and separate them from the adjacent vertebral bodies. With aging, both IVDs and EPs undergo degeneration. The Histologic Degeneration Score (HDS) is a grading system that microscopically evaluates the degree of degeneration in lumbar discs and predicts it with high accuracy basing on several histological markers of IVD and EP. There is currently a lack of validated histologic grading schemes for cervical spine degeneration...
January 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28094776/new-insights-into-cooperative-binding-of-homeodomain-transcription-factors-prep1-and-pbx1-to-dna
#10
Chiara Zucchelli, Elena Ferrari, Francesco Blasi, Giovanna Musco, Chiara Bruckmann
PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA binding. The kinetic parameters for DNA binding of individual PREP1 and PBX1 HDs, and of their combination, show that isolated PREP1 and PBX1 HDs bind to DNA in a cooperative manner. A novel PREP1 motif, flanking the HD at the C-terminus, is required for cooperativity...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072800/modified-percutaneous-lumbar-foraminoplasty-and-percutaneous-endoscopic-lumbar-discectomy-instrument-design-technique-notes-and-5-years-follow-up
#11
Zhen-Zhou Li, Shu-Xun Hou, Wei-Lin Shang, Ke-Ran Song, Hong-Liang Zhao
BACKGROUND: Conventional percutaneous endoscopic lumbar discectomy (PELD) with an "inside-outside" technique has 4.3% - 10.3% surgical failure rate, especially in central herniated discs (HDs), migrated HDs, and axillary type HDs. PELD with foraminoplasty has been used for complex HDs. Percutaneous lumbar foraminoplasty (PLF), which is performed with a trephine or bone reamer introduced over a guidewire without a protective working cannula in the original Tessys technique, can quickly cut the hypertrophied bony structure under fluoroscopic guidance, and risk injury to the exiting and traversing nerve roots...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28047917/tu-h-campus-jep2-01-inter-observer-delineation-comparison-of-visible-glandular-breast-tissue-on-magnetic-resonance-imaging-and-computed-tomography-prone-and-supine
#12
E M Pogson, G Delaney, V Ahern, M Boxer, S David, M Dimigen, J Harvey, E Koh, K Lim, G Papadatos, M Yap, V Batumalai, P Metcalfe, L Holloway
PURPOSE: Breast cancers predominantly arise from Glandular Breast Tissue (GBT). If the GBT can be treated effectively post-operatively utilising radiotherapy this may be adequate volumetric coverage for adjuvant breast radiotherapy. Adequate imaging of the GBT is necessary and will be assessed between MRI and CT modalities. GBT visualisation is acknowledged to be qualitatively superior on Magnetic Resonance Image (MRI) compared to Computed Tomography (CT), the current radiotherapy imaging standard, however this has not been quantitatively assessed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28017752/a-strategy-of-percutaneous-endoscopic-lumbar-discectomy-for-migrated-disc-herniation
#13
Kyung-Chul Choi, Dong Chan Lee, Hyeong-Ki Shim, Seung-Ho Shin, Choon-Keun Park
OBJECTIVE: Percutaneous endoscopic lumbar discectomy (PELD) with remarkable advancements has led to successful results comparable to open discectomy. However, its application in herniated disc (HD) with migration is still challenging and technically demanding. The purpose of this study is to propose various strategies for PELD according to HD with migration. METHODS: A retrospective review was performed on 434 consecutive patients who had undergone PELD. HD with migration was classified into four zones: low-grade up/down and high-grade up/down based on the extent and direction of migration...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28008330/increased-levels-of-circulating-and-tumor-infiltrating-granulocytic-myeloid-cells-in-colorectal-cancer-patients
#14
Salman M Toor, Azharuddin Sajid Syed Khaja, Haytham El Salhat, Omar Bekdache, Jihad Kanbar, Mohammed Jaloudi, Eyad Elkord
Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and their correlation with clinical settings. The aim of this study was to investigate levels and phenotype of myeloid cells in peripheral blood and tumor microenvironment (TME) of colorectal cancer (CRC) patients, compared to blood from healthy donors (HDs) and paired, adjacent non-tumor colon tissue...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27997399/structural-improvements-on-hydrodynamic-separators-a-computational-fluid-dynamics-approach
#15
Joseph Albert Mendoza, Dong Hoon Lee, Sang-Il Lee, Joo-Hyon Kang
Hydrodynamic separators (HDSs) have been used extensively to reduce stormwater pollutants from urbanized areas before entering the receiving water bodies. They primarily remove particulates and associated pollutants using gravity settling. Two types of HDSs with different structural configurations of the inner vortex-inducing components were presented in this study. One configuration consisted of a dip cylindrical plate with a center shaft while the other one has a hollow screen inside. With the help of computational fluid dynamics, the performance of these different types of HDSs have been evaluated and comparatively analyzed...
December 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27987577/coexistence-of-p16-cdkn2a-homozygous-deletions-and-activating-egfr-mutations-in-lung-adenocarcinoma-patients-signifies-a-poor-response-to-egfr-tkis
#16
Juhong Jiang, Yingying Gu, Jing Liu, Ruibin Wu, Lin Fu, Jin Zhao, Yubao Guan
OBJECTIVES: Activating mutations in the epidermal growth factor receptor (EGFR) are strongly predictive of EGFR-tyrosine kinase inhibitor (TKI) activity in non-small cell lung cancer (NSCLC). However, primary resistance to EGFR-TKIs occurs in approximately 20-30% of NSCLC patients with EGFR mutations. The goal of this study was to determine whether p16/CDKN2A homozygous deletion (HD) is associated with primary resistance to EGFR-TKIs in lung adenocarcinoma patients with EGFR activating mutations...
December 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27969574/disparities-in-hemodynamic-resuscitation-of-the-obese-critically-ill-septic-shock-patient
#17
Chere Adams, Calvin Tucker, Bryan Allen, Andrew McRae, Julia Balazh, Spencer Horst, Donald Johnson, Jason Ferreira
BACKGROUND: With a growing obesity epidemic, the approach to care of this patient remains controversial and in many circumstances different than the general population. Appropriate hemodynamic support, although still controversial, remains a cornerstone of septic shock therapy. Catecholamines are currently recommended by guidelines without a preferred dosing strategy. However, the use of weight-based (μg kg(-1) min(-1)) or nonweight-based (μg/min) vasopressor drip rates may impact patient care in these populations...
February 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/27967078/universality-and-dependence-on-initial-conditions-in-the-class-of-the-nonlinear-molecular-beam-epitaxy-equation
#18
I S S Carrasco, T J Oliveira
We report extensive numerical simulations of growth models belonging to the nonlinear molecular beam epitaxy (nMBE) class, on flat (fixed-size) and expanding substrates (ES). In both d=1+1 and 2+1, we find that growth regime height distributions (HDs), and spatial and temporal covariances are universal, but are dependent on the initial conditions, while the critical exponents are the same for flat and ES systems. Thus, the nMBE class does split into subclasses, as does the Kardar-Parisi-Zhang (KPZ) class. Applying the "KPZ ansatz" to nMBE models, we estimate the cumulants of the 1+1 HDs...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27893925/a-risk-based-measure-of-time-varying-prognostic-discrimination-for-survival-models
#19
C Jason Liang, Patrick J Heagerty
Prognostic survival models are commonly evaluated in terms of both their calibration and their discrimination. Comparing observed and predicted survival curves can assess calibration, while discrimination is typically summarized through comparison of the properties of "cases" or subjects who experience an event, and the properties of "controls" represented by event-free individuals. For binary data, discrimination is characterized either by using the relative ranks of cases and controls and a receiver operating characteristic (ROC) curve, or by summarizing the magnitude of risk placed on cases and controls through calculation of the discrimination slope (DS)...
November 28, 2016: Biometrics
https://www.readbyqxmd.com/read/27864476/anti-hinge-antibodies-recognize-igg-subclass-and-protease-restricted-neoepitopes
#20
Willem J J Falkenburg, Dirkjan van Schaardenburg, Pleuni Ooijevaar-de Heer, Michel W P Tsang-A-Sjoe, Irene E M Bultink, Alexandre E Voskuyl, Arthur E H Bentlage, Gestur Vidarsson, Gertjan Wolbink, Theo Rispens
Anti-hinge Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG. In this study, we explored the diversity of protease- and IgG subclass-restricted AHAs and their potential as immunological markers in healthy donors (HDs) and patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). AHA reactivity against IgG-degrading enzyme of Streptococcus pyogenes (IdeS)- or pepsin-generated F(ab')2 fragments of all four human IgG subclasses was determined. AHA reactivity against one or more out of eight F(ab')2 targets was found in 68% (68 of 100) of HDs, 69% (68 of 99) of SLE patients, and 81% (79 of 97) of RA patients...
January 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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