keyword
MENU ▼
Read by QxMD icon Read
search

HDS

keyword
https://www.readbyqxmd.com/read/27893925/a-risk-based-measure-of-time-varying-prognostic-discrimination-for-survival-models
#1
C Jason Liang, Patrick J Heagerty
Prognostic survival models are commonly evaluated in terms of both their calibration and their discrimination. Comparing observed and predicted survival curves can assess calibration, while discrimination is typically summarized through comparison of the properties of "cases" or subjects who experience an event, and the properties of "controls" represented by event-free individuals. For binary data, discrimination is characterized either by using the relative ranks of cases and controls and a receiver operating characteristic (ROC) curve, or by summarizing the magnitude of risk placed on cases and controls through calculation of the discrimination slope (DS)...
November 28, 2016: Biometrics
https://www.readbyqxmd.com/read/27864476/anti-hinge-antibodies-recognize-igg-subclass-and-protease-restricted-neoepitopes
#2
Willem J J Falkenburg, Dirkjan van Schaardenburg, Pleuni Ooijevaar-de Heer, Michel W P Tsang-A-Sjoe, Irene E M Bultink, Alexandre E Voskuyl, Arthur E H Bentlage, Gestur Vidarsson, Gertjan Wolbink, Theo Rispens
Anti-hinge Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG. In this study, we explored the diversity of protease- and IgG subclass-restricted AHAs and their potential as immunological markers in healthy donors (HDs) and patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). AHA reactivity against IgG-degrading enzyme of Streptococcus pyogenes (IdeS)- or pepsin-generated F(ab')2 fragments of all four human IgG subclasses was determined. AHA reactivity against one or more out of eight F(ab')2 targets was found in 68% (68 of 100) of HDs, 69% (68 of 99) of SLE patients, and 81% (79 of 97) of RA patients...
November 18, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27852394/-mechanism-of-alpha-lipoic-acid-in-treating-tnbs-induced-colitis-in-mice
#3
J Sun, M J Sun
Objective: To investigate whether α-lipoic acid (ALA) regulates autophagy in the pathogenesis of colitis through the mammalian target of rapamycin (mTOR) signaling pathway. Methods: Balb/c mouse colitis model was induced with 2, 4, 6-trinitrobenzenesulfonic acid (TNBS). Male Balb/c mice (22-25 g) were divided into four groups: control group, ALA group, colitis group, and ALA treatment group, with 10 mice in each group. ALA was administered at a dose of 80 mg/kg once a day for 7 days. The colon weight index, the disease activity index (DAI) and the histologic degeneration score (HDS) of colon tissue in each group were calculated...
November 1, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27847745/carbohydrate-electrolyte-drinks-exhibit-risks-for-human-enamel-surface-loss
#4
Mary Anne Sampaio de Melo, Vanara Florêncio Passos, Juliana Paiva Marques Lima, Sérgio Lima Santiago, Lidiany Karla Azevedo Rodrigues
OBJECTIVES: The aim of this investigation was to give insights into the impact of carbohydrate-electrolyte drinks on the likely capacity of enamel surface dissolution and the influence of human saliva exposure as a biological protective factor. MATERIALS AND METHODS: The pH, titratable acidity (TA) to pH 7.0, and buffer capacity (β) of common beverages ingested by patients under physical activity were analyzed. Then, we randomly distributed 50 specimens of human enamel into 5 groups...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27842768/herbal-and-dietary-supplement-induced-liver-injury
#5
REVIEW
Ynto S de Boer, Averell H Sherker
The increase in the use of herbal and dietary supplements (HDSs) over the last decades has been accompanied by an increase in the reports of HDS-associated hepatotoxicity. The spectrum of HDS-induced liver injury is diverse and the outcome may vary from transient liver test increases to fulminant hepatic failure resulting in death or requiring liver transplant. There are no validated standardized tools to establish the diagnosis, but some HDS products have a typical clinical signature that may help to identify HDS-induced liver injury...
February 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/27800077/cholera-public-health-surveillance-in-the-republic-of-cameroon-opportunities-and-challenges
#6
Moise Chi Ngwa, Song Liang, Leonard Mbam Mbam, Arabi Mouhaman, Andrew Teboh, Kaousseri Brekmo, Onana Mevoula, John Glenn Morris
INTRODUCTION: In Cameroon, cholera has periodically resurfaced since it was first reported in 1971. In 2003, Cameroon adapted the Integrated Disease Surveillance and Response (IDSR) strategy to strengthen surveillance in the country. This study was an in-depth description and assessment of the structure, core and support functions, and attributes of the current cholera surveillance system in Cameroon. It also discussed its strengths and challenges with hope that lessons learned could improve the system in Cameroon and in other countries in Africa implementing the IDSR strategy...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27756298/an-assessment-of-the-impact-of-herb-drug-combinations-used-by-cancer-patients
#7
Saud M Alsanad, Rachel L Howard, Elizabeth M Williamson
BACKGROUND: Herb/Dietary Supplements (HDS) are the most popular Complementary and Alternative Medicine (CAM) modality used by cancer patients and the only type which involves the ingestion of substances which may interfere with the efficacy and safety of conventional medicines. This study aimed to assess the level of use of HDS in cancer patients undergoing treatment in the UK, and their perceptions of their effects, using 127 case histories of patients who were taking HDS. Previous studies have evaluated the risks of interactions between HDS and conventional drugs on the basis on numbers of patient using HDSs, so our study aimed to further this exploration by examining the actual drug combinations taken by individual patients and their potential safety...
October 18, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27733036/evaluation-report-on-the-causal-association-between-humidifier-disinfectants-and-lung-injury
#8
Mina Ha, Soon Young Lee, Seung-Sik Hwang, Hyesook Park, Seungsoo Sheen, Hae Kwan Cheong, Bo Youl Choi
OBJECTIVES: As of November 2011, the Korean government recalled and banned humidifier disinfectants (HDs) from the market, because four case-control studies and one retrospective epidemiological study proved the association between HDs and lung injury of unknown cause. The report reviewed the causal role of HDs in lung injury based on scientific evidences. METHODS: A careful examination on the association between the HDs and lung injury was based on the criteria of causality inference by Hill and the US Surgeon General Expert Committee...
2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27721206/the-cortical-thickness-correlates-of-clinical-manifestations-in-the-mid-stage-sporadic-parkinson-s-disease
#9
Xia Deng, Chun-Yan Tang, Jie Zhang, Lei Zhu, Zun-Chun Xie, Hong-Han Gong, Xiang-Zuo Xiao, Ren-Shi Xu
The cortical thickness has gained an extensive attention as a pathological alteration of sporadic Parkinson's disease (sPD), the alteration of pathological cortical thickness may distinctly contribute to the consistent clinical manifestations. Therefore, we investigated the cortical thickness correlates of clinical manifestations in the mid-stage sPD from the Han population of Chinese mainland (HPCM). A sample of 67 mid-stage sPD patients and 35 matched controls from HPCM were performed a corticometry of magnetic resonance imaging (MRI) and the assessment of clinical manifestations including the demographic and disease-related characteristics, and underwent the final analysis of the cortical thickness correlates with the clinical manifestations...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27712132/diagnostic-utility-of-the-hiv-dementia-scale-and-the-international-hiv-dementia-scale-in-screening-for-hiv-associated-neurocognitive-disorders-among-spanish-speaking-adults
#10
Enrique López, Alexander J Steiner, Kimberly Smith, Nicholas S Thaler, David J Hardy, Andrew J Levine, Hussah T Al-Kharafi, Cristina Yamakawa, Karl Goodkin
Given that neurocognitive impairment is a frequent complication of HIV-1 infection in Spanish-speaking adults, the limited number of studies assessing HIV-associated neurocognitive disorders (HAND) in this population raises serious clinical concern. In addition to being appropriately translated, instruments need to be modified, normed, and validated accordingly. The purpose of the current study was to examine the diagnostic utility of the HIV Dementia Scale (HDS) and International HIV Dementia Scale (IHDS) to screen for HAND in Spanish-speaking adults living with HIV infection...
August 15, 2016: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/27707927/tmprss12-is-an-activating-protease-for-subtype-b-avian-metapneumovirus
#11
Bingling Yun, Yao Zhang, Yongzhen Liu, Xiaolu Guan, Yongqiang Wang, Xiaole Qi, Hongyu Cui, Changjun Liu, Yanping Zhang, Honglei Gao, Li Gao, Kai Li, Yulong Gao, Xiaomei Wang
: The entry of avian metapneumovirus (aMPV) into host cells initially requires the fusion of viral and cell membranes, which is exclusively mediated by fusion (F) protein. Proteolysis of aMPV F protein by endogenous proteases of host cells allows F protein to induce membrane fusion; however, these proteases have not been identified. Here, we provide the first evidence that the transmembrane serine protease TMPRSS12 facilitates the cleavage of subtype B aMPV (aMPV/B) F protein. We found that overexpression of TMPRSS12 enhanced aMPV/B F protein cleavage, F protein fusogenicity, and viral replication...
October 5, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27677775/liver-injury-from-herbal-and-dietary-supplements
#12
Victor Navarro, Ikhlas Khan, Einar Björnsson, Leonard B Seeff, Jose Serrano, Jay H Hoofnagle
Herbal and dietary supplements (HDS) are used increasingly both in the United States and worldwide and HDS induced liver injury in the U.S. has increased proportionally. Current challenges in the diagnosis and management of HDS-induced liver injury were the focus of a 2-day research symposium sponsored by the American Association for the Study of Liver Disease and the National Institutes of Health. HDS-induced liver injury now accounts for 20% of cases of hepatotoxicity in the United States based on research data...
September 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27668197/maternal-uterine-artery-doppler-in-the-first-and-second-trimesters-as-screening-method-for-hypertensive-disorders-and-adverse-perinatal-outcomes-in-low-risk-pregnancies
#13
Rosiane Maciel Scandiuzzi, Caio Antonio de Campos Prado, Edward Araujo Júnior, Geraldo Duarte, Silvana Maria Quintana, Fabrício da Silva Costa, Gabriele Tonni, Ricardo de Carvalho Cavalli, Alessandra Cristina Marcolin
OBJECTIVE: To assess the maternal demographic characteristics and uterine artery (UA) Doppler parameters at first and second trimesters of pregnancy as predictors for hypertensive disorders (HDs) and adverse perinatal outcomes. METHODS: This prospective cohort study comprised 162 singleton low-risk women undergoing routine antenatal care. The left and right UA were assessed by color and pulsed Doppler and the mean pulsatility and resistance indices as well as the presence of a bilateral protodiastolic notch were recorded at 11 to 14 and 20 to 24 weeks' gestation...
September 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27664934/impaired-akt-phosphorylation-in-b-cells-of-patients-with-common-variable-immunodeficiency
#14
Reza Yazdani, Mazdak Ganjalikhani-Hakemi, Mohammad Esmaeili, Hassan Abolhassani, Shahram Vaeli, Abbas Rezaei, Zohre Sharifi, Gholamreza Azizi, Nima Rezaei, Asghar Aghamohammadi
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency characterized by recurrent infectious. We evaluated whether defective PI3K/Akt/FoxO pathway could influence B-cell fate. Determination of B-cell subsets in CVD patients and healthy donors (HDs) were performed using flow cytometry. We evaluated mRNA level and protein expression of PI3K, Akt and FoxO molecules using real-time PCR and flow cytometry, respectively. Moreover, phosphorylated Akt (p-Akt) expression in B-cells has also been measured by flowcytometry...
September 21, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27663569/loss-of-anti-her-3-cd4-t-helper-type-1-immunity-occurs-in-breast-tumorigenesis-and-is-negatively-associated-with-outcomes
#15
Megan Fracol, Jashodeep Datta, Lea Lowenfeld, Shuwen Xu, Paul J Zhang, Carla S Fisher, Brian J Czerniecki
BACKGROUND: We previously demonstrated a progressive loss of the anti-human epidermal growth factor receptor 2 (HER2) CD4+ T-helper type 1 (Th1) response during HER2(pos) breast tumorigenesis. This loss is associated with residual disease following neoadjuvant therapy and increased risk of recurrence. In this study, we assessed the fate of anti-HER3 Th1 immunity during breast tumorigenesis. METHODS: Peripheral blood from 131 subjects, including healthy donors (HDs), patients with benign breast disease (BD), ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC), was collected...
September 23, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27659637/a-survey-of-dental-practitioners-in-wales-to-evaluate-the-management-of-deep-carious-lesions-with-vital-pulp-therapy-in-permanent-teeth
#16
J S Chin, M B Thomas, M Locke, P M H Dummer
Objective To evaluate the management of deep carious lesions with vital pulp therapy in permanent teeth by dental practitioners within Wales.Design Postal questionnaire.Setting General practitioners (GDS), community (CDS) and hospital-based dentists (HDS) in Wales.Methods Community and hospital dental services with a remit for provision of restorative dentistry (CDS = 71; HDS = 46) and general dental practitioners (N = 510) were approached regarding their management of deep carious lesions with vital pulp therapy in permanent teeth...
September 23, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27642302/whole-genome-expression-analysis-and-signal-pathway-screening-of-synovium-derived-mesenchymal-stromal-cells-in-rheumatoid-arthritis
#17
Jingyi Hou, Yi Ouyang, Haiquan Deng, Zhong Chen, Bin Song, Zhongyu Xie, Peng Wang, Jinteng Li, Weiping Li, Rui Yang
Synovium-derived mesenchymal stromal cells (SMSCs) may play an important role in the pathogenesis of rheumatoid arthritis (RA) and show promise for therapeutic applications in RA. In this study, a whole-genome microarray analysis was used to detect differential gene expression in SMSCs from RA patients and healthy donors (HDs). Our results showed that there were 4828 differentially expressed genes in the RA group compared to the HD group; 3117 genes were upregulated, and 1711 genes were downregulated. A Gene Ontology analysis showed significantly enriched terms of differentially expressed genes in the biological process, cellular component, and molecular function domains...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27640208/implementation-of-a-quantum-cascade-laser-based-gas-sensor-prototype-for-sub-ppmv-h2s-measurements-in-a-petrochemical-process-gas-stream
#18
Harald Moser, Walter Pölz, Johannes Paul Waclawek, Johannes Ofner, Bernhard Lendl
The implementation of a sensitive and selective as well as industrial fit gas sensor prototype based on wavelength modulation spectroscopy with second harmonic detection (2f-WMS) employing an 8-μm continuous-wave distributed feedback quantum cascade laser (CW-DFB-QCL) for monitoring hydrogen sulfide (H2S) at sub-ppm levels is reported. Regarding the applicability for analytical and industrial process purposes aimed at petrochemical environments, a synthetic methane (CH4) matrix of up to 1000 ppmv together with a varying H2S content was chosen as the model environment for the laboratory-based performance evaluation performed at TU Wien...
September 17, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27591029/association-of-ga-hba1c-ratio-and-cognitive-impairment-in-subjects-with-type-2-diabetes-mellitus
#19
Tomoe Kinoshita, Masashi Shimoda, Junpei Sanada, Yoshiro Fushimi, Yurie Hirata, Shintaro Irie, Akihito Tanabe, Atsushi Obata, Tomohiko Kimura, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIMS: The aim of this study was to search for factors influencing cognitive impairment and to clarify the association between the fluctuation of blood glucose levels and cognitive impairment in elderly Japanese subjects with type 2 diabetes. METHODS: We recruited 88 relatively elderly subjects (≥65years old) with type 2 diabetes who were hospitalized in Kawasaki Medical School from January 2014 to December 2015. We evaluated the fluctuation of blood glucose levels with glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio, and estimated cognitive impairment with Hasegawa dementia scale-revised (HDS-R) score and mini mental state examination (MMSE) score...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27536542/the-dynamics-of-mucosal-associated-invariant-t-cells-in-multiple-sclerosis
#20
Chie Sugimoto, Makoto Hirotani, Kazunori Yoshikiyo, Uichi Koshimizu, Rika Wakao, Takahiro Horinouchi, Yuichi Mazaki, Tsunehiko Higashi, Toshiyuki Fukazawa, Hiroyoshi Fujita, Hidenao Sasaki, Hiroshi Wakao
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination, gliosis and axonal loss in the Central Nervous System. Although the etiology of the disease has remained enigmatic, recent studies have suggested a role of the innate-like T cells, called Mucosal Associated Invariant T cells (MAITs) in the pathophysiology. In the present study, we have analyzed the relative frequency of MAITs and the expression of the cell surface antigens in MAITs to seek a possible link to the disease...
2016: SpringerPlus
keyword
keyword
49209
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"