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Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Background: Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. Objective: The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS. Methods: Serum was obtained from 94 patients: 26 clinically isolated syndrome (CIS), 40 relapsing-remitting MS (RRMS), 19 secondary progressive MS (SPMS), and nine primary progressive MS (PPMS)...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Manman Liu, Junli Liu, Shumeng Hao, Ping Wu, Xiaoyan Zhang, Yichuan Xiao, Gengru Jiang, Xinfang Huang
Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-time PCR was used to assess the mRNA expression of IFNG, type II IFN-inducible genes (IRF1, GBP1, CXCL9, CXCL10, and SERPING1, which are used for the type II IFN score), type I IFN-inducible genes (IRF7, MX1, ISG15, and ISG20, which are used for the type I IFN score), TBX21, and EOMES in peripheral blood mononuclear cells...
May 17, 2018: Clinical Rheumatology
Kun Guo, Yi Ding, Jun Luo, Zhixin Yu
First-row transition metal based thiospinels are prepared via a one-pot versatile strategy and for the first time investigated as hydrodesulfurization (HDS) catalysts. XRD, TEM and XPS analysis confirm that these thiospinels consist of agglomerated nanoparticles (NPs) and contain multivalent metal cations. Among the sulfides synthesized at 230 °C, NiCo2S4 presents the highest thiophene conversion. This high intrinsic activity is found to be correlated with the normal spinel structure with Ni cations located on the tetrahedral sites and Co cations on the octahedral sites...
May 17, 2018: ACS Applied Materials & Interfaces
Jukka Pappinen, Päivi Laukkanen-Nevala, Pekka Mäntyselkä, Jouni Kurola
BACKGROUND: In Finland, hospital districts (HD) are required by law to determine the level and availability of Emergency Medical Services (EMS) for each 1-km2 sized area (cell) within their administrative area. The cells are currently categorised into five risk categories based on the predicted number of missions. Methodological defects and insufficient instructions have led to incomparability between EMS services. The aim of this study was to describe a new, nationwide method for categorising the cells, analyse EMS response time data and describe possible differences in mission profiles between the new risk category areas...
May 15, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Yuanyuan Ji, Zhidong Wang, Haiyan Chen, Lei Zhang, Fei Zhuo, Qingqing Yang
BACKGROUND/AIMS: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and development of HCC. However, the relationship between HBV infection and IGF-II functions remains to be elucidated. METHODS: Levels of circulating IGF-II and IGF-I receptor (IGF-IR) in healthy donors (HDs) and CHB patients were tested by ELISA...
May 9, 2018: Cellular Physiology and Biochemistry
David E Kleiner
Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic findings considering patients' medical history and drug exposure. The liver biopsy findings may suggest alternative explanations of the injury and additional testing that should be performed to exclude non-DILI causes. Recent reports of iatrogenic liver injury are reviewed with attention to immunomodulatory and antineoplastic agents as well as reports of injury associated with HDS use...
June 2018: Surgical Pathology Clinics
Mari A Bernabeu-Martínez, Mateo Ramos Merino, Juan M Santos Gago, Luis M Álvarez Sabucedo, Carmina Wanden-Berghe, Javier Sanz-Valero
OBJECTIVE: To review the scientific literature related to the safe handling of hazardous drugs (HDs). METHOD: Critical analysis of works retrieved from MEDLINE, the Cochrane Library, Scopus, CINHAL, Web of Science and LILACS using the terms "Hazardous Substances", "Antineoplastic Agents" and "Cytostatic Agents", applying "Humans" and "Guidelines" as filters. Date of search: January 2017. RESULTS: In total, 1100 references were retrieved, and from those, 61 documents were selected based on the inclusion and exclusion criteria: 24 (39...
2018: PloS One
Eduardo Fernandes Bondan, Carolina Cardoso Vieira, Maria de Fátima Monteiro Martins, Thiago Berti Kirsten, Maria Martha Bernardi
Obesity is associated with a chronic and low-grade inflammatory response in the hypothalamus, where astrogliosis occurs with the upregulation of the astrocyte structural protein GFAP. As propentofylline (PPF) has inhibitory effects on astrocyte and microglial activation during inflammation, this study aimed to investigate if this xanthine derivative could decrease the astrocyte reaction induced by a hypercaloric diet (HD). Male Wistar rats were divided into four groups: NDS - rats receiving a normocaloric diet (ND) and daily saline solution; NDP - rats receiving ND and daily PPF (12...
April 2018: Arquivos de Neuro-psiquiatria
Nicola Bizzaro, Martina Fabris
BACKGROUND: The correct identification of anti-dense fine speckled-70 (DFS70) antibodies represents an important issue in the detection of anti-nuclear antibodies (ANAs) as performed by the indirect immunofluorescence (IIF) test on HEp-2 substrates. In this study, we have evaluated a new method for anti-DFS70 antibody detection employing HEp-2 cells knocked-out for the DFS70 antigen. METHODS: We studied 148 sera with a DFS70-like pattern (91 positive and 57 negative when tested for anti-DFS70 antibodies by a specific chemoluminescence [CLIA] method); 116 sera with infectious disease; 100 healthy donors (HDs), 139 samples from patients with a defined diagnosis of autoimmune rheumatic disease (ARD), and 242 consecutive unselected samples screened for ANA during the routine work-up...
May 6, 2018: Autoimmunity
I Borges, Alexander M Silva, Lucas Modesto-Costa
Single-sheet nanoclusters of MoS2 , NiMoS or CoMoS are widely used in hydrodesulfurization (HDS) catalysis in the petroleum industry. In HDS reactions under microwave irradiation, experiments indirectly pointed out that for pristine MoS2 reaction rates are accelerated because hot spots are generated on the catalyst bed. In this work, we investigated NiMoS and CoMoS isolated single-sheet substituted catalysts before and after thiophene adsorption focusing on quantifying the effect of microwave irradiation. For that purpose, density functional theory (DFT) molecular charge densities of each system were decomposed according to the distributed multipole analysis (DMA) of Stone...
May 4, 2018: Journal of Molecular Modeling
Abhishek Parija, Yun-Hyuk Choi, Zhuotong Liu, Justin L Andrews, Luis R De Jesus, Sirine C Fakra, Mohammed Al-Hashimi, James D Batteas, David Prendergast, Sarbajit Banerjee
Molybdenum disulfide (MoS2 ) is a semiconducting transition metal dichalcogenide that is known to be a catalyst for both the hydrogen evolution reaction (HER) as well as for hydro-desulfurization (HDS) of sulfur-rich hydrocarbon fuels. Specifically, the edges of MoS2 nanostructures are known to be far more catalytically active as compared to unmodified basal planes. However, in the absence of the precise details of the geometric and electronic structure of the active catalytic sites, a rational means of modulating edge reactivity remain to be developed...
April 25, 2018: ACS Central Science
Afroditi Nanou, Frank A W Coumans, Guus van Dalum, Leonie L Zeune, David Dolling, Wendy Onstenk, Mateus Crespo, Mariane Sousa Fontes, Pasquale Rescigno, Gemma Fowler, Penny Flohr, Christoph Brune, Stefan Sleijfer, Johann S de Bono, Leon W M M Terstappen
Purpose: The presence of Circulating Tumor Cells (CTCs) in Castration-Resistant Prostate Cancer (CRPC) patients is associated with poor prognosis. In this study, we evaluated the association of clinical outcome in 129 CRPC patients with CTCs, tumor-derived Extracellular Vesicles (tdEVs) and plasma levels of total (CK18) and caspase-cleaved cytokeratin 18 (ccCK18). Experimental Design: CTCs and tdEVs were isolated with the CellSearch system and automatically enumerated...
April 10, 2018: Oncotarget
Maryam Barekat, Shahnaz Ahmadi
Hypertensive disorders (HDs) as the most prevalent medical problem during pregnancy, predispose the patient to a lot of comorbidities and may even cause maternal or fetal death. The rate of infertility has been increasing in recent decades. So, we collected and summarized data about the co-existence of these two entities and found that HDs are somewhat more common in women receiving fertility treatments regardless of pathophysiologic correlation of infertility and hypertension or older age and chance of multiple pregnancies...
July 2018: International Journal of Fertility & Sterility
Sachiko Fujiwara, Tsubasa S Matsui, Kazumasa Ohashi, Shinji Deguchi, Kensaku Mizuno
Cell-substrate adhesions are essential for various physiological processes, including embryonic development and maintenance of organ functions. Hemidesmosomes (HDs) are multiprotein complexes that attach epithelial cells to the basement membrane. Formation and remodeling of HDs are dependent on the surrounding mechanical environment; however, the upstream signaling mechanisms are not well understood. We recently reported that Solo (also known as ARHGEF40), a guanine nucleotide exchange factor targeting RhoA, binds to keratin8/18 (K8/K18) intermediate filaments, and that their interaction is important for force-induced actin and keratin cytoskeletal reorganization...
2018: PloS One
Anders Bodin, Ann-Louise Nygård Christoffersen, Christian Fink Elkjær, Michael Brorson, Jakob Kibsgaard, Stig Helveg, Ib Chorkendorff
Nanoparticle engineering for catalytic applications requires both a synthesis technique for production of well-defined nanoparticles as well as measurements of their catalytic performance. In this paper, we present a new approach to rationally engineering highly active Ni-Mo-S nanoparticle catalysts for hydrodesulfurization (HDS), i.e. removal of sulfur from fossil fuels. Nanoparticle catalysts are synthesized by sputtering of a Mo75Ni25 metal target in a reactive atmosphere of Ar and H2S, followed by gas aggregation of the sputtered material into nanoparticles...
April 17, 2018: Nano Letters
Eun Lee, Seung Kook Son, Jisun Yoon, Hyun Ju Cho, Song I Yang, Sungsu Jung, Kyung Hyun Do, Young Ah Cho, So Yeon Lee, Dong Uk Park, Soo Jong Hong
Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH)...
April 16, 2018: Journal of Korean Medical Science
Bijan C Mekoba, Erin M Turingan, Patricia A Roberts, Susan Mason, Ian Willoughby, Cindy Taylor, Andrew Stivers, John Valgus
PURPOSE: One academic medical center's efforts to move toward compliance with requirements of United States Pharmacopeia ( USP ) chapter 800 through a multidepartmental collaborative initiative are described. SUMMARY: Requirements of USP general chapter 800 (enforceable as of December 2019) address the handling of hazardous drugs (HDs) throughout the entire operational and clinical cycle, from receiving to compounding, administration, and waste disposal. Due to the variety of pharmacy operational areas in which HDs are encountered at University of North Carolina Medical Center (UNCMC), multiple pharmacy managers oversee the safe handling of HDs...
April 12, 2018: American Journal of Health-system Pharmacy: AJHP
Yoshikane Yamauchi, Seyer Safi, Carolin Blattner, Anchana Rathinasamy, Ludmila Umansky, Simone Juenger, Arne Warth, Martin Eichhorn, Thomas Muley, Felix J F Herth, Hendrik Dienemann, Michael Platten, Philipp Beckhove, Jochen Utikal, Hans Hoffmann, Viktor Umansky
Rationale Myeloid-derived suppressor cell (MDSC) expansion has been found to play a role in disease progression in cancer patients. However, the characteristics of MDSCs in lung cancer are poorly understood. Objectives We prospectively investigated MDSCs and inflammatory factors in tumor and peripheral blood samples from patients with resectable non-small cell lung cancer (NSCLC) and studied their correlations with the disease prognosis. Methods A complex analysis of MDSC subsets and inflammatory mediators was performed using flow cytometry and a Bio-Plex assay...
April 4, 2018: American Journal of Respiratory and Critical Care Medicine
Zeynep Soyman, Hafize Uzun, Nihan Bayindir, Mukaddes Esrefoglu, Birtan Boran
PURPOSE: The occurrence of ovarian damage is a major shortcoming in treating tumors with cisplatin (CP). The present study investigates the beneficial effects of ebselen-a seleno-organic compound with antioxidant and antiinflammatory properties-vis-à-vis CP-induced ovarian damage. METHODS: Twenty-eight adult female rats were divided into four study groups. Group 1 received no treatment. The rats in Groups 2, 3, and 4 were intraperitoneally administered CP (2 mg/kg/day) twice per week, for 5 weeks...
March 29, 2018: Archives of Gynecology and Obstetrics
Junjie Zhao, Berc Kalanyan, Heather F Barton, Brent A Sperling, Gregory N Parsons
In situ chemical measurements of solution/surface reactions during metal-organic framework (MOF) thin film growth can provide valuable information about the mechanistic and kinetic aspects of key reaction steps, and allow control over crystal quality and material properties. Here, we report a new approach to study the growth of MOF thin films in a flow cell using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Real-time spectra recorded during continuous flow synthesis were used to investigate the mechanism and kinetics that govern the formation of (Zn, Cu) hydroxy double salts (HDSs) from ZnO thin films and the subsequent conversion of HDS to HKUST-1...
October 24, 2017: Chemistry of Materials: a Publication of the American Chemical Society
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