Daniel Eisenson, Yu Hisadome, Michelle Santillan, Hayato Iwase, WeiLi Chen, Akira Shimizu, Alex Schulick, Du Gu, Armaan Akbar, Alice Zhou, Kristy Koenig, Kasinath Kuravi, Farzana Rahman, Lori Sorrells, Lars Burdorf, Kristina DeSmet, Daniel Warren, Leigh Peterson, Marc Lorber, David Ayares, Andrew Cameron, Kazuhiko Yamada
Xenotransplantation represents a possible solution to the organ shortage crisis and is an imminent clinical reality with long-term xenograft survival in pig-to-nonhuman primate (NHP) heart and kidney large animal models, and short-term success in recent human decedent and clinical studies. However, concerns remain about safe clinical translation of these results, given the inconsistency in published survival as well as key differences between preclinical procurement and immunosuppression and clinical standards-of-care...
April 18, 2024: Nature Communications