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https://www.readbyqxmd.com/read/29921713/%C3%AE-2%C3%AE-1-is-essential-for-sympathetic-output-and-nmda-receptor-activity-potentiated-by-angiotensin-ii-in-the-hypothalamus
#1
Huijie Ma 马会杰, Shao-Rui Chen 陈少瑞, Hong Chen 陈红, Lingyong Li 李令勇, De-Pei Li 李德培李德培, Jing-Jing Zhou 周京京, Hui-Lin Pan 潘惠麟
Both the sympathetic nervous system and renin-angiotensin system are critically involved in hypertension development. Although angiotensin II (Ang II) stimulates hypothalamic paraventricular nucleus (PVN) neurons to increase sympathetic vasomotor tone, the molecular mechanism mediating this action remains unclear. The glutamate N -methyl- D -aspartate receptor (NMDAR) in the PVN controls sympathetic outflow in hypertension. In this study, we determined the interaction between α2δ-1 (encoded by Cacna2d1 ), commonly known as a Ca2+ channel subunit, and NMDARs in the hypothalamus and its role in Ang II-induced synaptic NMDAR activity in PVN presympathetic neurons...
June 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29917241/a-structurally-derived-model-of-subunit-dependent-nmda-receptor-function
#2
Alasdair Gibb, Kevin K Ogden, Miranda J McDaniel, Katie M Vance, Steven A Kell, Chris Butch, Pieter Burger, Dennis C Liotta, Stephen F Traynelis
NMDA receptors (NMDARs) are tetrameric complexes comprising two glycine-binding GluN1 and two glutamate-binding GluN2 subunits. Four GluN2 subunits encoded by different genes can produce up to ten different di- and triheteromeric receptors. In addition, some neurological patients contain a de novo mutation or inherited rare variant in only one subunit. There is currently no mechanistic framework to describe tetrameric receptor function that can be extended to receptors with two different GluN1 or GluN2 subunits...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29916144/nmda-receptors-containing-glun2b-2c-2d-subunits-mediate-an-increase-in-glutamate-release-at-hippocampal-ca3-ca1-synapses
#3
J Prius-Mengual, M Pérez-Rodríguez, Y Andrade-Talavera, A Rodríguez-Moreno
NMDA receptors (NMDARs) are involved in synaptic transmission and synaptic plasticity in different brain regions, and they modulate glutamate release at different presynaptic sites. Here, we studied whether non-postsynaptic NMDARs, putatively presynaptic (preNMDARs), are tonically active at hippocampal CA3-CA1 synapses, and if they modulate glutamate release. We found that when postsynaptic NMDARs are blocked by MK801, D-AP5 depresses evoked and spontaneous excitatory synaptic transmission, indicating that preNMDARs are tonically active at CA3-CA1 synapses, facilitating glutamate release...
June 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29915659/a-case-report-anti-nmda-receptor-encephalitis
#4
Pavan Bhat, Ameer Ahmed, Preetam Jolepalem, Charmian Sittambalam
N -methyl-d-aspartate receptor (NMDAR) antibody encephalitis is a potentially fatal autoimmune syndrome in which there is antibody production against the NMDAR causing profound dysregulation of neurotransmission. The syndrome is frequently associated with ovarian teratomas and women are disproportionately affected. Patients most often present with a constellation of neuropsychiatric signs and symptoms, including memory loss, hallucinations, and decreased level of consciousness. This condition is lethal if left untreated...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915530/-n-glycosylation-regulates-the-trafficking-and-surface-mobility-of-glun3a-containing-nmda-receptors
#5
Kristyna Skrenkova, Sanghyeon Lee, Katarina Lichnerova, Martina Kaniakova, Hana Hansikova, Martin Zapotocky, Young Ho Suh, Martin Horak
N -methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of GluN1/GluN2 subunits. Previous studies showed that GluN1/GluN2 receptors are regulated by N -glycosylation; however, limited information is available regarding the role of N -glycosylation in GluN3A-containing NMDARs. Using a combination of microscopy, biochemistry, and electrophysiology in mammalian cell lines and rat hippocampal neurons, we found that two asparagine residues (N203 and N368) in the GluN1 subunit and three asparagine residues (N145, N264 and N275) in the GluN3A subunit are required for surface delivery of GluN3A-containing NMDARs...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29913137/memantine-rescues-prenatal-citalopram-exposure-induced-striatal-and-social-abnormalities-in-mice
#6
Aqeela Zahra, Jinxiang Jiang, Yunan Chen, Cheng Long, Li Yang
Prenatal exposure to citalopram (CTM), an antidepressant drug, has been associated with altered behavior, including autism-like symptoms in both human and rodent offspring. However, the neurological basis underlying these abnormal behaviors is not well understood. Here, we examined behavioral, morphological, and biochemical alterations in the male and female offspring of C57BL/6 mouse mothers that had been exposed to CTM during the last trimester of gestation. We observed abnormal behavior such as anxiety, altered locomotion and disordered social interactions in 2-5 month old offspring with prenatal CTM exposure...
June 15, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29911316/de-palmitoylation-by-n-tert-butyl-hydroxylamine-inhibits-ampar-mediated-synaptic-transmission-via-affecting-receptor-distribution-in-postsynaptic-densities
#7
Zhi-Xuan Xia, Zu-Cheng Shen, Shao-Qi Zhang, Ji Wang, Tai-Lei Nie, Qiao Deng, Jian-Guo Chen, Fang Wang, Peng-Fei Wu
AIMS: Palmitoylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) subunits or their "scaffold" proteins produce opposite effects on AMPAR surface delivery. Considering AMPARs have long been identified as suitable drug targets for central nervous system (CNS) disorders, targeting palmitoylation signaling to regulate AMPAR function emerges as a novel therapeutic strategy. However, until now, much less is known about the effect of palmitoylation-deficient state on AMPAR function...
June 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29904645/infection-triggered-autoimmunity-the-case-of-herpes-simplex-virus-type-1-and-anti-nmdar-antibodies
#8
EDITORIAL
Russell C Dale, Margherita Nosadini
No abstract text is available yet for this article.
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29898386/camkii-metaplasticity-drives-a%C3%AE-oligomer-mediated-synaptotoxicity
#9
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K Ulrich Bayer, Christophe Mulle, Daniel Choquet
Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity. Indeed, reminiscent of metaplasticity, oligomeric forms of the amyloid-β peptide (oAβ) prevent induction of long-term potentiation (LTP) via the prior activation of GluN2B-containing NMDA receptors (NMDARs). However, the downstream Ca2+ -dependent signaling molecules that mediate aberrant metaplasticity are unknown. In this study, we show that oAβ promotes the activation of Ca2+ /calmodulin-dependent kinase II (CaMKII) via GluN2B-containing NMDARs...
June 12, 2018: Cell Reports
https://www.readbyqxmd.com/read/29895894/nmdar-independent-camp-dependent-antidepressant-actions-of-ketamine
#10
Nathan H Wray, Jeffrey M Schappi, Harinder Singh, Nicolas B Senese, Mark M Rasenick
Ketamine produces rapid and robust antidepressant effects in depressed patients within hours of administration, often when traditional antidepressant compounds have failed to alleviate symptoms. We hypothesized that ketamine would translocate Gαs from lipid rafts to non-raft microdomains, similarly to other antidepressants but with a distinct, abbreviated treatment duration. C6 glioma cells were treated with 10 µM ketamine for 15 min, which translocated Gαs from lipid raft domains to non-raft domains...
June 12, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29893546/lack-of-effect-of-sodium-benzoate-at-reported-clinical-therapeutic-concentration-on-d-alanine-metabolism-in-dogs
#11
Michael Popiolek, Brendan Tierney, Stefanus J Steyn, Michael De Vivo
Cognitive decline and psychosis have been hypothesized to be mediated by N-methyl-D-aspartate receptor (NMDAR) hypofunction. Consistent with this hypothesis, chronic treatment with D-alanine, a co-agonist at the glycine site of the NMDAR, lead to an improvement of positive and cognitive symptoms in schizophrenic patients. D-alanine is oxidized by D-amino acid oxidase (DAAO) thus an inhibitor of DAAO would be expected to enhance D-alanine levels and likewise lead to desirable clinical outcomes. Sodium benzoate, on the basis of D-amino acid inhibition, was observed to display beneficial clinical effects in schizophrenic and Alzheimer's patients...
June 12, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29891949/postsynaptic-rim1-modulates-synaptic-function-by-facilitating-membrane-delivery-of-recycling-nmdars-in-hippocampal-neurons
#12
Jiejie Wang, Xinyou Lv, Yu Wu, Tao Xu, Mingfei Jiao, Risheng Yang, Xia Li, Ming Chen, Yinggang Yan, Changwan Chen, Weifan Dong, Wei Yang, Min Zhuo, Tao Chen, Jianhong Luo, Shuang Qiu
NMDA receptors (NMDARs) are crucial for excitatory synaptic transmission and synaptic plasticity. The number and subunit composition of synaptic NMDARs are tightly controlled by neuronal activity and sensory experience, but the molecular mechanism mediating NMDAR trafficking remains poorly understood. Here, we report that RIM1, with a well-established role in presynaptic vesicle release, also localizes postsynaptically in the mouse hippocampus. Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory...
June 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29891511/primary-lateral-sclerosis-like-picture-in-a-patient-with-a-remote-history-of-anti-n-methyl-d-aspartate-receptor-anti-nmdar-antibody-encephalitis
#13
Mubeen Janmohamed, Wally Knezevic, Merrilee Needham, Sam Salman
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a well-recognised disorder, first fully characterised in 2007. The long-term sequelae reported thus far include relapses with typical, as well as partial aspects of the well-defined neuropsychiatric syndrome. Rarely, isolated atypical symptoms (diplopia, ataxia and tremor) have been reported as relapse phenomenon. We report a case of a patient with a remote history of likely anti-NMDAR encephalitis with the longest follow-up reported in the literature to date (22 years)...
June 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29884518/timing-in-the-treatment-of-status-epilepticus-from-basics-to-the-clinic
#14
REVIEW
Marina Gaínza-Lein, Iván Sánchez Fernández, Adriana Ulate-Campos, Tobias Loddenkemper, Adam P Ostendorf
OBJECTIVE: Describe basic science, animal models and clinical data related to timing of treatment in status epilepticus (SE). METHODS: We summarized the results of 15 studies that reported time to treatment in SE, and reviewed basic and clinical literature. RESULTS: SE is a life-threatening and time-sensitive emergency that requires immediate treatment. Current guidelines recommend escalation of anti-seizure medications (ASM) within specified time frames...
June 1, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29883723/nmda-and-gaba-receptor-presence-in-rat-heart-mitochondria
#15
Semen V Nesterov, Yulia A Skorobogatova, Alisa A Panteleeva, Lyubov L Pavlik, Irina B Mikheeva, Lev S Yaguzhinsky, Yaroslav R Nartsissov
The purpose of this study is to demonstrate the presence of three more receptors in mitochondria. Two N-methyl-d-aspartate receptor (NMDAR) subunits (NR1 and NR2B) are found by protein immunoblot and immunogold labeling in mitochondria fraction isolated from rat heart. These data allow supposing NMDAR presence and functioning in the inner mitochondrial membrane. There are no signs of receptor presence obtained in heart tissue lysate, that indicates the receptor localization exactly in mitochondria. The possible receptor functions discussed are its participation in calcium transport and in excitation-metabolism coupling...
June 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29879390/overcoming-depression-by-inhibition-of-neural-burst-firing
#16
Daesoo Kim, Eunji Cheong, Hee-Sup Shin
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.
June 6, 2018: Neuron
https://www.readbyqxmd.com/read/29878094/tissue-type-plasminogen-activator-controlled-corticogenesis-through-a-mechanism-dependent-of-nmda-receptors-expressed-on-radial-glial-cells
#17
Nolwenn Pasquet, Sara Douceau, Mickael Naveau, Flavie Lesept, Morgane Louessard, Laurent Lebouvier, Yannick Hommet, Denis Vivien, Isabelle Bardou
Modifications of neuronal migration during development, including processes that control cortical lamination are associated with functional deficits at adult stage. Here, we report for the first time that the lack of the serine protease tissue-type Plasminogen Activator (tPA), previously characterized as a neuromodulator and a gliotransmitter, leads to an altered cortical lamination in adult. This results in a neuronal migration defect of tPA deficient neurons which are stopped in the intermediate zone at E16...
June 6, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29875651/prospects-of-zinc-supplementation-in-autism-spectrum-disorders-and-shankopathies-such-as-phelan-mcdermid-syndrome
#18
Simone Hagmeyer, Ann Katrin Sauer, Andreas M Grabrucker
The loss of one copy of SHANK3 (SH3 and multiple ankyrin repeat domains 3) in humans highly contributes to Phelan McDermid syndrome (PMDS). In addition, SHANK3 was identified as a major autism candidate gene. Interestingly, the protein encoded by the SHANK3 gene is regulated by zinc. While zinc deficiency depletes synaptic pools of Shank3, increased zinc levels were shown to promote synaptic scaffold formation. Therefore, the hypothesis arises that patients with PMDS and Autism caused by Shankopathies, having one intact copy of SHANK3 left, may benefit from zinc supplementation, as elevated zinc may drive remaining Shank3 into the post-synaptic density (PSD) and may additional recruit Shank2, a second zinc-dependent member of the SHANK gene family...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29872376/dissociated-role-of-d-serine-in-extinction-during-consolidation-vs-reconsolidation-of-context-conditioned-fear
#19
Ran Inoue, Gourango Talukdar, Keizo Takao, Tsuyoshi Miyakawa, Hisashi Mori
Extinction-based exposure therapy is widely used for the treatment of anxiety disorders, such as post-traumatic stress disorder (PTSD). D-serine, an endogenous co-agonist at the glycine-binding site of the N -methyl-D-aspartate-type glutamate receptor (NMDAR), has been shown to be involved in extinction of fear memory. Recent findings suggest that the length of time between the initial learning and an extinction session is a determinant of neural mechanism involved in fear extinction. However, how D-serine is involved in extinction of fear memory at different timings remains unclear...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29867362/inhibition-of-connexin-43-and-phosphorylated-nr2b-in-spinal-astrocytes-attenuates-bone-cancer-pain-in-mice
#20
Hui Yang, Hui Yan, Xin Li, Jing Liu, Shousong Cao, Baisheng Huang, Dong Huang, Lixiang Wu
Bone cancer pain (BCP) is common in patients with advanced cancers when the tumors are metastasized to bone. The limited understanding of the complex pathogenesis of BCP leads to the poor effectiveness of clinical treatment. Previous studies have shown that astrocyte-specific connexin (Cx) 43, a forming protein of gap junction (GJ) and hemichannel, and N-methyl-D-aspartate receptors (NMDARs), especially the phosphorylated NMDAR 2B subunit (NR2B) phosphorylated NR2B (p-NR2B) subunit are involved in BCP. However, the relationship between Cx43 and p-NR2B in BCP remains unclear...
2018: Frontiers in Cellular Neuroscience
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