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radiation complication in cervical cancer

Venkatesulu Bhanu Prasad, Supriya Mallick, G K Rath
INTRODUCTION: Cancer of the uterine cervix is the fourth most common cancer worldwide among women. However, there is limited data about elderly cervical cancer patients and gross underrepresentation of elderly patients in clinical trials. Hence, the optimal therapy of such patients is not well formulated. METHODOLOGY: We conducted this systematic review of evidence to assess patterns of care in elderly patients with cervical cancer. RESULTS: A total of 17,338 publications are reported in PubMed until July, 2016 pertaining to cervical cancer...
February 3, 2017: Journal of Geriatric Oncology
Virginia Benito, Sonia Carballo, Patricia Silva, Miriam Esparza, Octavio Arencibia, Mario Federico, Miguel Andújar, Marta Mori, Norberto Medina, Amina Lubrano
OBJECTIVE: To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic paraaortic lymphadenectomy (LPL), as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic paraaortic lymph nodes (PLN). DESIGN: Retrospective study conducted on demographic data, pathological and surgical findings, complications and disease-status, recorded for LACC patients undergoing LPL during the period 2009-2015...
February 1, 2017: Journal of Minimally Invasive Gynecology
H Yin, M E, H Zhang, C Wang
PURPOSE: The aim of this study was to evaluate radiotherapy in terms of both feasibility and efficacy for the treatment of 206 elderly patients (≥70 years) with unresectable ESCC and to investigate the factors that predict overall survival in those patients. METHODS: Totally, 206 elderly patients with esophageal cancer (≥70 years) treated with RT for ESCC in the Harbin Medical University Affiliated Tumor Hospital were retrospectively enrolled. Radiation treatment results and side effects were evaluated...
January 13, 2017: Clinical & Translational Oncology
X Chen, Y Song, B Erickson, X Li
PURPOSE: Acute hematologic toxicity associated with bone marrow injury is a common complication of chemoradiation therapy (CRT) for pelvic malignancies. In this work, we investigate the feasibility of using quantitative CT to detect bone marrow injury during CRT. METHODS: Daily CTs were acquired during routine CT-guided radiation therapy using a CT-on-rails for 15 cervical cancer patients. All patients treated with a radiation dose of 45.0 to 50.4 Gy in 1.8 Gy/fraction along with chemotherapy...
June 2016: Medical Physics
E Lee, F Yuan, A Templeton, R Yao, J Chu
PURPOSE: The ultimate goal of radiotherapy treatment planning is to find a treatment that will yield a high tumor-control-probability(TCP) with an acceptable normal-tissue-complication probability(NTCP). Yet most treatment planning today is not based upon optimization of TCPs and NTCPs, but rather upon meeting physical dose and volume constraints defined by the planner. We design treatment plans that optimize TCP directly and contrast them with the clinical dose-based plans. PET image is incorporated to evaluate gain in TCP for dose escalation...
June 2016: Medical Physics
Elisabeth Diver, Emily Hinchcliff, Allison Gockley, Alexander Melamed, Leah Contrino, Sarah Feldman, Whitfield Growdon
STUDY OBJECTIVE: To assess outcomes of women with cervical cancer undergoing upfront radical hysterectomy (RH) via a minimally invasive surgery (MIS) or a traditional laparotomy (XL) approach at 2 large US academic institutions to determine whether the mode of surgery affects patient outcomes. DESIGN: Retrospective cohort study (Canadian Task Force classification II-1). SETTING: Two academic medical institutions in the United States. PATIENTS: Women undergoing upfront RH for cervical cancer between 2000 and 2013...
December 21, 2016: Journal of Minimally Invasive Gynecology
Piotr Zelga, Marcin Tchórzewski, Marta Zelga, Janusz Sobotkowski, Adam Dziki
PURPOSE: Radiation-induced rectovaginal fistula (RI-RVF) is a chronic and serious condition with a significant influence on quality of life. The aim of this study is to evaluate the results of surgical treatment of rectovaginal fistulas of patients previously undergoing radiotherapy. METHODS: Fifty patients treated in the Gynaecological Radiotherapy Unit for gynaecologic malignancy and in the Department of General and Colorectal Surgery for RI-RVF between 2003 and 2013 were enrolled into a prospectively maintained database and underwent regular follow-up examinations in an outpatient clinic, during which surgical outcomes were assessed...
December 16, 2016: Langenbeck's Archives of Surgery
Nan Li, Ruben Carmona, Igor Sirak, Linda Kasaova, David Followill, Jeff Michalski, Walter Bosch, William Straube, Loren K Mell, Kevin L Moore
PURPOSE: To demonstrate an efficient method for training and validation of a knowledge-based planning (KBP) system as a radiation therapy clinical trial plan quality-control system. METHODS AND MATERIALS: We analyzed 86 patients with stage IB through IVA cervical cancer treated with intensity modulated radiation therapy at 2 institutions according to the standards of the INTERTECC (International Evaluation of Radiotherapy Technology Effectiveness in Cervical Cancer, National Clinical Trials Network identifier: 01554397) protocol...
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Zhong-Shan Liu, Jie Guo, Yang-Zhi Zhao, Xia Lin, Bin Chen, Ming Zhang, Jiang-Ming Li, Xiao-Jun Ren, Bing-Ya Zhang, Tie-Jun Wang
PURPOSE: Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents a new therapeutic technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT). MATERIAL AND METHODS: Sixteen patients with recurrent cervical cancer after radical surgery and adjuvant external-beam radiotherapy (EBRT) were included in this study. These patients underwent high-dose-rate (HDR) interstitial BT with free-hand placement of metal needles guided by real-time 3D-CT...
October 2016: Journal of Contemporary Brachytherapy
Lucas Goense, Peter S N van Rossum, Jelle P Ruurda, Marco van Vulpen, Stella Mook, Gert J Meijer, Richard van Hillegersberg
BACKGROUND: Concerns have been raised regarding the toxicity of neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer that could contribute to an increased risk of postoperative complications. The aim of this study was to determine the influence of the radiation dose to the gastric fundus on the risk of postoperative anastomotic leakage in patients undergoing nCRT followed by transthoracic esophagectomy. METHODS: Between January 2012 and July 2015, 97 consecutive patients who underwent nCRT followed by transthoracic esophagectomy were included in this single-center cohort study...
December 2016: Annals of Thoracic Surgery
Katsushi Takebayashi, Yasuhiro Tsubosa, Tomoyuki Kamijo, Yoshiyuki Iida, Atsushi Imai, Masato Nagaoka, Takashi Kitani, Masahiro Niihara, Eisuke Booka, Ayako Shimada, Masahiro Nakagawa, Tetsuro Onitsuka
BACKGROUND: Total pharyngolaryngectomy and cervical esophagectomy (TPLCE) after chemoradiotherapy remains a challenge because of the high rate of complications and few available data on outcomes and safety. The purpose of this study was to evaluate the clinical significance of salvage TPLCE and to compare treatment outcomes between hypopharyngeal cancer and cervical esophageal cancer. METHODS: Data from 37 consecutive patients who were diagnosed with potentially resectable hypopharyngeal and cervical esophageal cancer after chemoradiotherapy were retrospectively analyzed...
October 6, 2016: Annals of Surgical Oncology
Geneviève Bouchard-Fortier, Raymond H Kim, Lisa Allen, Abha Gupta, Taymaa May
OBJECTIVE: To report three cases of embryonal rhabdomyosarcoma (ERMS) of the cervix in young women successfully treated with fertility-sparing surgery and chemotherapy. METHODS: Between January 2014 and December 2015, three cases of ERMS of the cervix were confirmed in young women at a single tertiary cancer center. All cases were managed by a pediatric oncologist and a gynecologic oncologist with a combination of surgery and chemotherapy. Fertility-sparing surgeries (cervical conization or robotic-assisted radical trachelectomy) were offered to patients depending on the tumor size...
November 2016: Gynecologic Oncology Reports
Leslie H Clark, Emma L Barber, Paola A Gehrig, John T Soper, John F Boggess, Kenneth H Kim
OBJECTIVE: Open radical hysterectomy followed by adjuvant radiation for cervical cancer has been associated with significant rates of morbidity. Radical hysterectomy is now often performed robotically. We sought to examine if the robotic platform decreased the morbidity associated with radical hysterectomy followed by adjuvant radiation. MATERIALS/METHODS: A retrospective cohort of patients with cervical cancer undergoing radical hysterectomy from 1995 to 2013 was evaluated...
October 2016: International Journal of Gynecological Cancer
Evrim Duman, Aysun Inal, Aycan Sengul, Timur Koca, Yigit Cecen, Melek Nur Yavuz
AIM: The study evaluates the different treatment planning techniques according to three recommendation levels of the International Commission on Radiation Units and Measurements Report-83 in gynecologic cancer patients treated with adjuvant pelvic radiotherapy (APR). MATERIALS AND METHODS: Computerized tomography images of ten endometrial and cervical cancer patients who were treated with APR were assessed. For each patient, five different treatment plans were created...
April 2016: Journal of Cancer Research and Therapeutics
Yiming Zhu, Hong Zhang, Song Ni, Jian Wang, Dezhi Li, Shaoyan Liu
OBJECTIVE: To explore the clinical effects and short-term complications of using free jejunum graft (FJG) to reconstruct the defects by resections of pharyngeal, laryngeal or cervical esophageal cancers. METHOD: Fifty-eight cases of pharyngeal, laryngeal or cervical esophageal cancers were reconstructed with FJG. All cases were analyzed retrospectively. RESULT: The success rate of FJG transplantations was 91.4% (53/58). The incidence of post-operative short-term complication was 43...
February 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Kazuto Nakamura, Yoshikazu Kitahara, Toyomi Satoh, Yuji Takei, Masashi Takano, Shoji Nagao, Isao Sekiguchi, Mitsuaki Suzuki
BACKGROUND: There are no definitive criteria for identifying which patients with The International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer will benefit from adjuvant therapy after radical hysterectomy. The aims of this study were to clarify the efficacy of adjuvant therapy and assess complications after radical hysterectomy in patients with FIGO stage IB1 cervical cancer with intermediate risk factors. METHODS: Between January 2005 and December 2009, the medical records of 75 stage IB1 patients' intermediate risk factors (i...
2016: World Journal of Surgical Oncology
Fumiaki Isohashi, Seiji Mabuchi, Yuichi Akino, Yasuo Yoshioka, Yuji Seo, Osamu Suzuki, Keisuke Tamari, Kiyoshi Yoshino, Kenjiro Sawada, Yutaka Ueda, Eiji Kobayashi, Iori Sumida, Hirokazu Mizuno, Hirofumi Okubo, Tadashi Kimura, Kazuhiko Ogawa
The purpose of this study is to evaluate dose-volume histogram (DVH) predictors for the development of chronic gastrointestinal (GI) complications in patients with cervical cancer who have undergone postoperative concurrent chemotherapy and whole-pelvic radiation therapy (WPRT). The subjects were 135 patients who had undergone postoperative WPRT with concurrent nedaplatin-based chemotherapy between 2000 and 2014. Associations between selected DVH parameters and the incidence of chronic GI complications of G3 or higher were evaluated...
November 2016: Journal of Radiation Research
Yoshifumi Oku, Hidetaka Arimura, Tran Thi Thao Nguyen, Yoshiyuki Hiraki, Masahiko Toyota, Yasumasa Saigo, Takashi Yoshiura, Hideki Hirata
This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiation treatment plans, which have been designed based on planning CT images (and/or MR images) acquired just before the treatments, are adaptively applied for each fraction, taking into account the interfractional location variations...
November 2016: Journal of Radiation Research
F Fanfani, E Vizza, F Landoni, P de Iaco, G Ferrandina, G Corrado, V Gallotta, M A Gambacorta, A Fagotti, G Monterossi, A M Perrone, R Lazzari, S P Colangione, G Scambia
BACKGROUND: To compare patterns and rates of early and late complications, and survival outcome in FIGO stage III cervical cancer patients underwent to radical hysterectomy after chemo-radiation (CT-RT) vs. chemo-radiation alone. METHODS: Between May 1996 and April 2013 150 FIGO stage III cervical cancer patients were treated. We divide patients according to type of treatment: 77 were submitted to standard treatment (Group A), and 73 to completion hysterectomy after chemo-radiation (Group B)...
October 2016: European Journal of Surgical Oncology
Hiroshi Asano, Yukiharu Todo, Hidemichi Watari
The aim of this review is to address the current status of adjuvant chemotherapy alone in early-stage cervical cancer treatments in the literature. At present, the therapeutic effect of adjuvant chemotherapy alone after radical surgery (RS) has not yet been established, and radiation therapy (RT) or concurrent chemoradiotherapy (CCRT) is recommended as the standard adjuvant therapy after RS for early-stage cervical cancer in various guidelines. The main purpose of adjuvant therapy after RS, however, should be to reduce extrapelvic recurrence rather than local recurrence, although adjuvant RT or CCRT has survival benefits for patients with intermediate- or high-risk factors for recurrence...
April 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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